locus-tag	class	description
THTE_0002	COG0592	DNA-directed DNA polymerase activity
THTE_0004	COG0187	DNA topoisomerase II activity
THTE_0006	COG1309	transcriptional regulator
THTE_0008	COG1131	(ABC) transporter
THTE_0009	COG0842	Transport permease protein
THTE_0010	COG0842	Transport permease protein
THTE_0020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_0030	COG0443	Heat shock 70 kDa protein
THTE_0040	COG1305	Transglutaminase-like
THTE_0041	COG0793	Belongs to the peptidase S41A family
THTE_0046	COG0149	triose-phosphate isomerase activity
THTE_0048	COG1561	YicC-like family, N-terminal region
THTE_0049	COG0194	GDP metabolic process
THTE_0050	COG1758	RNA polymerase activity
THTE_0051	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THTE_0052	COG1959	2 iron, 2 sulfur cluster binding
THTE_0053	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THTE_0055	COG1013	pyruvate-flavodoxin oxidoreductase activity
THTE_0056	COG0674	pyruvate-flavodoxin oxidoreductase activity
THTE_0056	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THTE_0057	COG2239	Acts as a magnesium transporter
THTE_0064	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THTE_0068	COG0124	histidyl-tRNA synthetase
THTE_0073	COG0129	dihydroxy-acid dehydratase activity
THTE_0078	COG3494	Protein of unknown function (DUF1009)
THTE_0079	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THTE_0082	COG0529	Catalyzes the synthesis of activated sulfate
THTE_0084	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THTE_0087	COG3119	arylsulfatase activity
THTE_0088	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
THTE_0095	COG1940	carbohydrate kinase activity
THTE_0096	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THTE_0106	COG1355	regulation of microtubule-based process
THTE_0109	COG0564	pseudouridine synthase activity
THTE_0110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THTE_0115	COG0138	bifunctional purine biosynthesis protein purh
THTE_0120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THTE_0128	COG0233	cytoplasmic translational termination
THTE_0129	COG0528	UMP kinase activity
THTE_0130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THTE_0131	COG0052	Belongs to the universal ribosomal protein uS2 family
THTE_0144	COG0318	PFAM AMP-dependent synthetase and ligase
THTE_0153	COG1643	Atp-dependent helicase
THTE_0163	COG0095	Lipoate-protein ligase
THTE_0171	COG0247	lactate metabolic process
THTE_0172	COG1139	Iron-sulfur cluster binding protein
THTE_0173	COG1556	Lactate utilization protein
THTE_0177	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THTE_0182	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_0183	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THTE_0187	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THTE_0188	COG0047	phosphoribosylformylglycinamidine synthase activity
THTE_0193	COG0228	four-way junction DNA binding
THTE_0194	COG0336	Belongs to the RNA methyltransferase TrmD family
THTE_0195	COG0335	large ribosomal subunit rRNA binding
THTE_0197	COG0792	nuclease activity
THTE_0198	COG1366	Belongs to the anti-sigma-factor antagonist family
THTE_0203	COG3119	arylsulfatase activity
THTE_0204	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THTE_0205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THTE_0206	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THTE_0219	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THTE_0223	COG1082	Xylose isomerase domain protein TIM barrel
THTE_0228	COG0285	dihydrofolate synthase activity
THTE_0242	COG1131	(ABC) transporter
THTE_0245	COG2251	uridine kinase activity
THTE_0245	COG0195	Participates in both transcription termination and antitermination
THTE_0247	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THTE_0249	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THTE_0255	COG3852	Histidine kinase
THTE_0256	COG0385	Bile acid
THTE_0258	COG3604	Transcriptional regulator
THTE_0259	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
THTE_0262	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THTE_0264	COG1573	uracil-dna glycosylase
THTE_0265	COG2244	polysaccharide biosynthetic process
THTE_0266	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THTE_0268	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THTE_0272	COG0303	'Molybdopterin
THTE_0273	COG0315	cyclic pyranopterin monophosphate synthase activity
THTE_0274	COG0521	Mo-molybdopterin cofactor biosynthetic process
THTE_0274	COG0315	cyclic pyranopterin monophosphate synthase activity
THTE_0275	COG0746	molybdenum cofactor guanylyltransferase activity
THTE_0289	COG1234	tRNA 3'-trailer cleavage
THTE_0295	COG0440	acetolactate synthase activity
THTE_0296	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THTE_0299	COG0309	Hydrogenase expression formation protein (HypE)
THTE_0302	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THTE_0312	COG0673	inositol 2-dehydrogenase activity
THTE_0315	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THTE_0321	COG4968	Prepilin-type N-terminal cleavage methylation domain
THTE_0326	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_0330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THTE_0331	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THTE_0331	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THTE_0337	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTE_0337	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTE_0339	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THTE_0345	COG1181	Belongs to the D-alanine--D-alanine ligase family
THTE_0346	COG1181	Belongs to the D-alanine--D-alanine ligase family
THTE_0352	COG0017	Asparaginyl-tRNA synthetase
THTE_0353	COG0492	ferredoxin-NADP+ reductase activity
THTE_0363	COG0010	Belongs to the arginase family
THTE_0368	COG0835	chemotaxis
THTE_0370	COG0585	pseudouridine synthase activity
THTE_0374	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THTE_0382	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THTE_0387	COG3875	lactate racemase activity
THTE_0390	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTE_0405	COG1785	Belongs to the alkaline phosphatase family
THTE_0424	COG1971	Probably functions as a manganese efflux pump
THTE_0426	COG0129	dihydroxy-acid dehydratase activity
THTE_0428	COG1385	rRNA (uridine-N3-)-methyltransferase activity
THTE_0430	COG0517	IMP dehydrogenase activity
THTE_0430	COG1994	Peptidase M50
THTE_0432	COG0348	domain, Protein
THTE_0447	COG1254	Belongs to the acylphosphatase family
THTE_0455	COG2721	sulfolactate sulfo-lyase activity
THTE_0460	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
THTE_0465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THTE_0468	COG0527	aspartate kinase activity
THTE_0470	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THTE_0476	COG2815	serine threonine protein kinase
THTE_0476	COG0515	serine threonine protein kinase
THTE_0482	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THTE_0484	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
THTE_0485	COG0539	negative regulation of cytoplasmic translation
THTE_0491	COG2333	competence protein COMEC
THTE_0491	COG0658	competence protein
THTE_0492	COG0482	sulfurtransferase activity
THTE_0498	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_0503	COG0301	tRNA thio-modification
THTE_0503	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
THTE_0507	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_0521	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
THTE_0523	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_0526	COG1121	(ABC) transporter
THTE_0542	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THTE_0544	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_0555	COG1381	Involved in DNA repair and RecF pathway recombination
THTE_0557	COG0681	Belongs to the peptidase S26 family
THTE_0561	COG0531	amino acid
THTE_0564	COG0515	serine threonine protein kinase
THTE_0564	COG2815	serine threonine protein kinase
THTE_0574	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THTE_0576	COG2814	Major facilitator Superfamily
THTE_0579	COG3706	GGDEF domain
THTE_0579	COG0745	RESPONSE REGULATOR receiver
THTE_0580	COG1196	nuclear chromosome segregation
THTE_0582	COG2033	superoxide reductase activity
THTE_0586	COG0298	carbon dioxide binding
THTE_0587	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
THTE_0588	COG1663	tetraacyldisaccharide 4'-kinase activity
THTE_0596	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THTE_0596	COG0515	serine threonine protein kinase
THTE_0598	COG1070	Carbohydrate kinase
THTE_0601	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THTE_0612	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
THTE_0615	COG3132	Protein of unknown function, DUF480
THTE_0623	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THTE_0624	COG0215	cysteine-tRNA ligase activity
THTE_0625	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THTE_0628	COG3189	MarR family transcriptional regulator
THTE_0633	COG0175	sulfate reduction
THTE_0637	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_0639	COG0107	imidazoleglycerol-phosphate synthase activity
THTE_0640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THTE_0641	COG0450	alkyl hydroperoxide reductase
THTE_0650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
THTE_0653	COG2814	Major facilitator Superfamily
THTE_0664	COG0105	UTP biosynthetic process
THTE_0667	COG0067	glutamate synthase
THTE_0667	COG0069	glutamate synthase activity
THTE_0667	COG0070	glutamate synthase
THTE_0672	COG1136	(ABC) transporter
THTE_0672	COG0577	efflux transmembrane transporter activity
THTE_0673	COG1136	(ABC) transporter
THTE_0678	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THTE_0679	COG2046	Belongs to the sulfate adenylyltransferase family
THTE_0683	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THTE_0685	COG0784	Response regulator, receiver
THTE_0685	COG2205	protein histidine kinase activity
THTE_0685	COG5002	protein histidine kinase activity
THTE_0689	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
THTE_0695	COG0477	Major facilitator Superfamily
THTE_0696	COG1621	beta-fructofuranosidase activity
THTE_0697	COG0297	glycogen (starch) synthase activity
THTE_0697	COG0438	transferase activity, transferring glycosyl groups
THTE_0698	COG0646	methionine synthase
THTE_0698	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THTE_0704	COG2203	Gaf domain
THTE_0704	COG2199	diguanylate cyclase activity
THTE_0705	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THTE_0705	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THTE_0707	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THTE_0708	COG0357	Ribosomal RNA small subunit methyltransferase G
THTE_0710	COG2815	serine threonine protein kinase
THTE_0710	COG0515	serine threonine protein kinase
THTE_0721	COG2183	response to ionizing radiation
THTE_0722	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THTE_0726	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_0729	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THTE_0730	COG1509	lysine 2,3-aminomutase activity
THTE_0734	COG4464	protein tyrosine phosphatase activity
THTE_0740	COG4974	Belongs to the 'phage' integrase family
THTE_0756	COG0494	nUDIX hydrolase
THTE_0765	COG0114	fumarate hydratase activity
THTE_0767	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_0768	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_0769	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_0770	COG0649	NAD binding
THTE_0776	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_0779	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THTE_0782	COG1007	ATP synthesis coupled electron transport
THTE_0783	COG1216	Glycosyl transferase, family 2
THTE_0788	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THTE_0793	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THTE_0805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THTE_0806	COG1126	abc transporter atp-binding protein
THTE_0816	COG1131	(ABC) transporter
THTE_0818	COG3119	arylsulfatase activity
THTE_0822	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTE_0825	COG0539	negative regulation of cytoplasmic translation
THTE_0829	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THTE_0830	COG0750	zinc metalloprotease
THTE_0833	COG0575	Belongs to the CDS family
THTE_0837	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THTE_0839	COG0557	exoribonuclease II activity
THTE_0843	COG3118	belongs to the thioredoxin family
THTE_0844	COG0542	response to heat
THTE_0849	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THTE_0850	COG1185	polyribonucleotide nucleotidyltransferase activity
THTE_0853	COG3852	Histidine kinase
THTE_0855	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THTE_0860	COG2815	serine threonine protein kinase
THTE_0860	COG0515	serine threonine protein kinase
THTE_0864	COG5012	cobalamin binding
THTE_0865	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_0866	COG1166	arginine decarboxylase activity
THTE_0868	COG4608	Belongs to the ABC transporter superfamily
THTE_0869	COG0444	Belongs to the ABC transporter superfamily
THTE_0871	COG0601	transmembrane transport
THTE_0871	COG0601	transmembrane transport
THTE_0873	COG0616	signal peptide processing
THTE_0874	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
THTE_0875	COG4208	sulfate ABC transporter
THTE_0876	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
THTE_0878	COG3604	Transcriptional regulator
THTE_0881	COG3119	arylsulfatase activity
THTE_0883	COG0402	S-adenosylhomocysteine deaminase activity
THTE_0885	COG4555	ABC transporter
THTE_0886	COG3264	Mechanosensitive ion channel
THTE_0886	COG1511	domain protein
THTE_0900	COG3119	arylsulfatase activity
THTE_0901	COG0534	Mate efflux family protein
THTE_0903	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THTE_0905	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THTE_0906	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THTE_0907	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
THTE_0909	COG1966	Carbon starvation protein
THTE_0918	COG1410	methionine synthase
THTE_0918	COG0646	methionine synthase
THTE_0927	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THTE_0927	COG0072	phenylalanine-tRNA ligase activity
THTE_0928	COG0284	orotidine-5'-phosphate decarboxylase activity
THTE_0930	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THTE_0932	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THTE_0937	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THTE_0938	COG1993	acr, cog1993
THTE_0940	COG0515	serine threonine protein kinase
THTE_0944	COG0310	cobalt ion transport
THTE_0945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THTE_0946	COG1122	ATPase activity
THTE_0958	COG0840	transmembrane signaling receptor activity
THTE_0959	COG4566	intracellular signal transduction
THTE_0961	COG4191	Histidine kinase
THTE_1006	COG1595	DNA-templated transcription, initiation
THTE_1028	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
THTE_1029	COG0742	ribosomal rna small subunit methyltransferase
THTE_1032	COG3706	GGDEF domain
THTE_1032	COG0745	RESPONSE REGULATOR receiver
THTE_1036	COG0515	serine threonine protein kinase
THTE_1039	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THTE_1040	COG2255	four-way junction helicase activity
THTE_1048	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_1051	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
THTE_1053	COG0006	proline dipeptidase activity
THTE_1054	COG0511	ligase activity, forming carbon-carbon bonds
THTE_1055	COG0439	Biotin carboxylase
THTE_1056	COG0205	6-phosphofructokinase activity
THTE_1063	COG0864	Transcriptional regulator
THTE_1064	COG0217	transcriptional regulatory protein
THTE_1067	COG0640	Transcriptional regulator
THTE_1075	COG1131	(ABC) transporter
THTE_1076	COG1725	Transcriptional regulator
THTE_1087	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THTE_1090	COG4191	Histidine kinase
THTE_1091	COG2204	response regulator
THTE_1094	COG1677	Flagellar hook-basal body complex protein FliE
THTE_1096	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_1098	COG1157	protein secretion by the type III secretion system
THTE_1102	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
THTE_1104	COG1582	Flagellar protein (FlbD)
THTE_1106	COG1360	Flagellar Motor Protein
THTE_1110	COG1338	Plays a role in the flagellum-specific transport system
THTE_1111	COG1987	bacterial-type flagellum assembly
THTE_1113	COG1684	flagellar biosynthetic protein fliR
THTE_1114	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THTE_1117	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THTE_1119	COG1419	protein localization to endoplasmic reticulum
THTE_1123	COG1191	sigma factor activity
THTE_1136	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THTE_1139	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THTE_1142	COG0356	it plays a direct role in the translocation of protons across the membrane
THTE_1144	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THTE_1145	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THTE_1146	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THTE_1147	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THTE_1148	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THTE_1149	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THTE_1152	COG1045	serine acetyltransferase
THTE_1153	COG1131	(ABC) transporter
THTE_1156	COG0540	Belongs to the ATCase OTCase family
THTE_1157	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THTE_1159	COG0151	Belongs to the GarS family
THTE_1162	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
THTE_1168	COG0109	protoheme IX farnesyltransferase activity
THTE_1172	COG0714	Associated with various cellular activities
THTE_1181	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THTE_1184	COG0039	L-malate dehydrogenase activity
THTE_1196	COG0516	GMP reductase activity
THTE_1196	COG0517	IMP dehydrogenase activity
THTE_1202	COG1418	mRNA catabolic process
THTE_1203	COG1692	metallophosphoesterase
THTE_1211	COG1652	LysM domain
THTE_1213	COG1862	Preprotein translocase
THTE_1227	COG0459	protein refolding
THTE_1228	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THTE_1240	COG3119	arylsulfatase activity
THTE_1243	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
THTE_1262	COG2815	serine threonine protein kinase
THTE_1262	COG0515	serine threonine protein kinase
THTE_1264	COG2877	3-deoxy-8-phosphooctulonate synthase activity
THTE_1267	COG0254	rRNA binding
THTE_1268	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THTE_1269	COG2890	protein-(glutamine-N5) methyltransferase activity
THTE_1276	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THTE_1282	COG0848	biopolymer transport protein
THTE_1283	COG0848	biopolymer transport protein
THTE_1284	COG0811	peptide transport
THTE_1288	COG2890	protein-(glutamine-N5) methyltransferase activity
THTE_1290	COG0438	transferase activity, transferring glycosyl groups
THTE_1292	COG0367	asparagine synthase
THTE_1294	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THTE_1296	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THTE_1299	COG0165	Argininosuccinate lyase
THTE_1304	COG2204	response regulator
THTE_1306	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
THTE_1308	COG2201	protein-glutamate methylesterase activity
THTE_1314	COG1349	DNA-binding transcription factor activity
THTE_1315	COG4869	propanediol catabolic process
THTE_1316	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THTE_1317	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
THTE_1319	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THTE_1320	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
THTE_1325	COG0235	Class ii aldolase
THTE_1330	COG0606	chelatase, subunit chli
THTE_1333	COG0698	ribose 5-phosphate isomerase
THTE_1337	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_1349	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_1354	COG0673	inositol 2-dehydrogenase activity
THTE_1356	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_1356	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
THTE_1360	COG0495	leucyl-tRNA aminoacylation
THTE_1365	COG1082	Xylose isomerase domain protein TIM barrel
THTE_1366	COG0840	transmembrane signaling receptor activity
THTE_1368	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_1370	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THTE_1371	COG1450	Type ii and iii secretion system protein
THTE_1376	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
THTE_1386	COG0051	transcription antitermination factor activity, RNA binding
THTE_1387	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THTE_1388	COG0088	Forms part of the polypeptide exit tunnel
THTE_1389	COG0089	rRNA binding
THTE_1390	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THTE_1391	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THTE_1392	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THTE_1393	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THTE_1394	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THTE_1395	COG0255	Belongs to the universal ribosomal protein uL29 family
THTE_1396	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THTE_1397	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THTE_1398	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THTE_1399	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THTE_1401	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THTE_1402	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THTE_1403	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THTE_1404	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THTE_1405	COG0200	Binds to the 23S rRNA
THTE_1407	COG0563	adenylate kinase activity
THTE_1409	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THTE_1410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THTE_1411	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THTE_1412	COG0202	RNA polymerase activity
THTE_1413	COG0203	ribosomal protein L17
THTE_1424	COG0704	Plays a role in the regulation of phosphate uptake
THTE_1431	COG3119	arylsulfatase activity
THTE_1441	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
THTE_1448	COG1151	hydroxylamine reductase activity
THTE_1450	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
THTE_1451	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THTE_1464	COG0358	DNA primase activity
THTE_1467	COG1199	ATP-dependent helicase activity
THTE_1486	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_1488	COG3401	FG-GAP repeat protein
THTE_1490	COG2095	MarC family integral membrane protein
THTE_1497	COG3386	PFAM SMP-30 Gluconolaconase
THTE_1501	COG0714	Associated with various cellular activities
THTE_1509	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
THTE_1512	COG0723	plastoquinol--plastocyanin reductase activity
THTE_1513	COG0493	'glutamate synthase
THTE_1513	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THTE_1514	COG1959	2 iron, 2 sulfur cluster binding
THTE_1526	COG2181	nitrate reductase activity
THTE_1526	COG0247	lactate metabolic process
THTE_1529	COG2181	nitrate reductase activity
THTE_1529	COG0247	lactate metabolic process
THTE_1533	COG1620	l-lactate permease
THTE_1543	COG1337	RAMP superfamily
THTE_1559	COG1793	dna ligase
THTE_1559	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THTE_1564	COG3119	arylsulfatase activity
THTE_1570	COG1477	protein flavinylation
THTE_1575	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THTE_1577	COG1388	LysM domain
THTE_1578	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THTE_1587	COG0179	Fumarylacetoacetate (FAA) hydrolase
THTE_1589	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
THTE_1593	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THTE_1597	COG0673	inositol 2-dehydrogenase activity
THTE_1601	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_1603	COG0673	inositol 2-dehydrogenase activity
THTE_1604	COG1595	DNA-templated transcription, initiation
THTE_1606	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THTE_1611	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THTE_1613	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THTE_1625	COG0443	Heat shock 70 kDa protein
THTE_1628	COG0793	Belongs to the peptidase S41A family
THTE_1631	COG1070	Carbohydrate kinase
THTE_1635	COG0354	folic acid binding
THTE_1646	COG1459	type II secretion system
THTE_1648	COG1091	dTDP-4-dehydrorhamnose reductase activity
THTE_1653	COG2022	thiamine diphosphate biosynthetic process
THTE_1663	COG1609	Transcriptional regulator
THTE_1663	COG2207	Transcriptional regulator
THTE_1671	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THTE_1673	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THTE_1678	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_1679	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_1681	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
THTE_1682	COG0839	Belongs to the complex I subunit 6 family
THTE_1684	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THTE_1686	COG1007	ATP synthesis coupled electron transport
THTE_1688	COG0084	hydrolase, TatD family'
THTE_1690	COG0326	Molecular chaperone. Has ATPase activity
THTE_1692	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THTE_1693	COG1078	dGTPase activity
THTE_1697	COG0552	protein localization to endoplasmic reticulum
THTE_1698	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THTE_1699	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THTE_1700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THTE_1701	COG0237	dephospho-CoA kinase activity
THTE_1702	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THTE_1702	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THTE_1706	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
THTE_1707	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THTE_1707	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THTE_1709	COG1335	isochorismatase
THTE_1711	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
THTE_1712	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
THTE_1712	COG0517	IMP dehydrogenase activity
THTE_1713	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THTE_1717	COG1355	regulation of microtubule-based process
THTE_1719	COG3174	membrane
THTE_1724	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
THTE_1741	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
THTE_1782	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_1784	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_1785	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
THTE_1788	COG0653	protein targeting
THTE_1789	COG1519	Transferase
THTE_1795	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
THTE_1797	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THTE_1798	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THTE_1810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THTE_1811	COG1459	type II secretion system
THTE_1813	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THTE_1815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
THTE_1818	COG1074	ATP-dependent DNA helicase activity
THTE_1820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THTE_1825	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THTE_1826	COG0436	Aminotransferase
THTE_1831	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
THTE_1833	COG1490	D-aminoacyl-tRNA deacylase activity
THTE_1836	COG0825	malonyl-CoA metabolic process
THTE_1839	COG0101	tRNA pseudouridine synthase activity
THTE_1840	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THTE_1846	COG0561	phosphatase activity
THTE_1853	COG2146	nitrite reductase [NAD(P)H] activity
THTE_1854	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THTE_1855	COG0166	Belongs to the GPI family
THTE_1860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THTE_1867	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THTE_1870	COG5002	protein histidine kinase activity
THTE_1875	COG0573	inorganic phosphate transmembrane transporter activity
THTE_1879	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THTE_1882	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THTE_1883	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
THTE_1890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
THTE_1892	COG1482	cell wall glycoprotein biosynthetic process
THTE_1894	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THTE_1895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
THTE_1904	COG2204	response regulator
THTE_1905	COG5000	phosphorelay sensor kinase activity
THTE_1910	COG5002	protein histidine kinase activity
THTE_1913	COG2204	response regulator
THTE_1916	COG0515	serine threonine protein kinase
THTE_1916	COG2815	serine threonine protein kinase
THTE_1918	COG0028	Belongs to the TPP enzyme family
THTE_1923	COG2738	Putative neutral zinc metallopeptidase
THTE_1925	COG0673	inositol 2-dehydrogenase activity
THTE_1934	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THTE_1935	COG1657	PFAM Prenyltransferase squalene oxidase
THTE_1936	COG0673	inositol 2-dehydrogenase activity
THTE_1947	COG1131	(ABC) transporter
THTE_1950	COG0473	3-isopropylmalate dehydrogenase activity
THTE_1953	COG0673	inositol 2-dehydrogenase activity
THTE_1956	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THTE_1957	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THTE_1957	COG0116	Belongs to the methyltransferase superfamily
THTE_1961	COG0745	RESPONSE REGULATOR receiver
THTE_1964	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THTE_1967	COG0488	(ABC) transporter
THTE_1968	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
THTE_1969	COG1960	acyl-CoA dehydrogenase activity
THTE_1970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THTE_1971	COG2086	electron transfer activity
THTE_1980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THTE_1981	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THTE_1983	COG1722	exodeoxyribonuclease VII activity
THTE_1984	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THTE_1984	COG0519	Catalyzes the synthesis of GMP from XMP
THTE_1986	COG0148	phosphopyruvate hydratase activity
THTE_1992	COG0673	inositol 2-dehydrogenase activity
THTE_1994	COG3119	arylsulfatase activity
THTE_1996	COG0673	inositol 2-dehydrogenase activity
THTE_1998	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THTE_2002	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THTE_2011	COG1570	exodeoxyribonuclease VII activity
THTE_2012	COG0811	peptide transport
THTE_2017	COG0673	inositol 2-dehydrogenase activity
THTE_2018	COG0302	gtp cyclohydrolase
THTE_2019	COG0247	lactate metabolic process
THTE_2024	COG0167	dihydroorotate dehydrogenase activity
THTE_2025	COG0180	Tryptophanyl-tRNA synthetase
THTE_2027	COG0736	holo-[acyl-carrier-protein] synthase activity
THTE_2030	COG3869	Catalyzes the specific phosphorylation of arginine residues in
THTE_2031	COG3119	arylsulfatase activity
THTE_2037	COG0423	glycine-tRNA ligase activity
THTE_2039	COG0438	transferase activity, transferring glycosyl groups
THTE_2041	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
THTE_2044	COG3119	arylsulfatase activity
THTE_2052	COG5012	cobalamin binding
THTE_2057	COG3119	arylsulfatase activity
THTE_2066	COG3119	arylsulfatase activity
THTE_2071	COG0243	molybdopterin cofactor binding
THTE_2082	COG0248	Ppx GppA phosphatase
THTE_2083	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
THTE_2084	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTE_2085	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THTE_2086	COG3360	Dodecin
THTE_2087	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THTE_2090	COG1605	Chorismate mutase
THTE_2090	COG0077	Prephenate dehydratase
THTE_2100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THTE_2103	COG4806	L-rhamnose isomerase
THTE_2109	COG3345	alpha-galactosidase
THTE_2111	COG2115	Belongs to the xylose isomerase family
THTE_2112	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THTE_2116	COG1716	ATPase activity
THTE_2116	COG1131	(ABC) transporter
THTE_2116	COG0842	Transport permease protein
THTE_2118	COG0515	serine threonine protein kinase
THTE_2127	COG0494	nUDIX hydrolase
THTE_2130	COG2333	competence protein COMEC
THTE_2130	COG0658	competence protein
THTE_2137	COG4124	Belongs to the glycosyl hydrolase 26 family
THTE_2146	COG0471	metal ion transport
THTE_2146	COG3273	potassium ion transport
THTE_2158	COG1595	DNA-templated transcription, initiation
THTE_2160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_2163	COG1136	(ABC) transporter
THTE_2165	COG0673	inositol 2-dehydrogenase activity
THTE_2169	COG0798	PFAM Bile acid sodium symporter
THTE_2172	COG0730	response to heat
THTE_2175	COG1940	carbohydrate kinase activity
THTE_2175	COG1846	Transcriptional regulator
THTE_2183	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
THTE_2185	COG0277	FAD linked oxidase domain protein
THTE_2186	COG0277	FAD linked oxidase domain protein
THTE_2190	COG0205	6-phosphofructokinase activity
THTE_2191	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THTE_2192	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THTE_2200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
THTE_2201	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THTE_2202	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
THTE_2205	COG2264	protein methyltransferase activity
THTE_2208	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THTE_2211	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THTE_2212	COG1012	belongs to the aldehyde dehydrogenase family
THTE_2216	COG0268	Binds directly to 16S ribosomal RNA
THTE_2219	COG1160	GTP binding
THTE_2220	COG0489	protein tyrosine kinase activity
THTE_2229	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_2232	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
THTE_2237	COG0343	queuine tRNA-ribosyltransferase activity
THTE_2238	COG0202	RNA polymerase activity
THTE_2248	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_2248	COG0706	membrane insertase activity
THTE_2249	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THTE_2250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THTE_2255	COG0587	DNA-directed DNA polymerase activity
THTE_2261	COG0604	alcohol dehydrogenase
THTE_2263	COG0673	inositol 2-dehydrogenase activity
THTE_2269	COG0363	glucosamine-6-phosphate deaminase activity
THTE_2272	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THTE_2274	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THTE_2276	COG3119	arylsulfatase activity
THTE_2279	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
THTE_2280	COG0564	pseudouridine synthase activity
THTE_2289	COG0515	serine threonine protein kinase
THTE_2289	COG2815	serine threonine protein kinase
THTE_2290	COG0563	adenylate kinase activity
THTE_2291	COG0438	transferase activity, transferring glycosyl groups
THTE_2293	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTE_2294	COG0822	iron-sulfur transferase activity
THTE_2296	COG0556	nucleotide-excision repair
THTE_2311	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_2312	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_2313	COG0673	inositol 2-dehydrogenase activity
THTE_2315	COG0653	protein targeting
THTE_2321	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THTE_2323	COG3119	arylsulfatase activity
THTE_2324	COG3119	arylsulfatase activity
THTE_2344	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THTE_2345	COG0438	transferase activity, transferring glycosyl groups
THTE_2346	COG0463	Glycosyl transferase, family 2
THTE_2348	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THTE_2353	COG1216	Glycosyl transferase, family 2
THTE_2356	COG0438	transferase activity, transferring glycosyl groups
THTE_2358	COG0463	Glycosyl transferase, family 2
THTE_2362	COG0438	transferase activity, transferring glycosyl groups
THTE_2365	COG0438	transferase activity, transferring glycosyl groups
THTE_2368	COG0438	transferase activity, transferring glycosyl groups
THTE_2371	COG1215	transferase activity, transferring glycosyl groups
THTE_2378	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THTE_2380	COG0489	protein tyrosine kinase activity
THTE_2385	COG1160	GTP binding
THTE_2386	COG1116	anion transmembrane transporter activity
THTE_2390	COG3119	arylsulfatase activity
THTE_2395	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THTE_2403	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_2404	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THTE_2405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
THTE_2409	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THTE_2414	COG2201	protein-glutamate methylesterase activity
THTE_2422	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THTE_2422	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THTE_2425	COG2234	aminopeptidase activity
THTE_2427	COG1129	ABC transporter
THTE_2428	COG1172	Belongs to the binding-protein-dependent transport system permease family
THTE_2432	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THTE_2433	COG2205	protein histidine kinase activity
THTE_2433	COG2202	Pas domain
THTE_2435	COG0328	RNA-DNA hybrid ribonuclease activity
THTE_2436	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THTE_2437	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTE_2438	COG0109	protoheme IX farnesyltransferase activity
THTE_2439	COG0163	prenyltransferase activity
THTE_2440	COG2226	methyltransferase
THTE_2442	COG2045	Belongs to the ComB family
THTE_2446	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THTE_2447	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THTE_2448	COG0604	alcohol dehydrogenase
THTE_2449	COG0442	prolyl-tRNA aminoacylation
THTE_2452	COG3481	metal-dependent phosphohydrolase, HD sub domain
THTE_2458	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THTE_2459	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THTE_2461	COG0812	UDP-N-acetylmuramate dehydrogenase activity
THTE_2465	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
THTE_2466	COG0714	Associated with various cellular activities
THTE_2471	COG0445	tRNA wobble uridine modification
THTE_2473	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
THTE_2475	COG2201	protein-glutamate methylesterase activity
THTE_2477	COG0512	Glutamine amidotransferase of anthranilate synthase
THTE_2478	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THTE_2479	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
THTE_2482	COG0667	Aldo Keto reductase
THTE_2485	COG2193	ferroxidase activity
THTE_2494	COG0617	tRNA 3'-terminal CCA addition
THTE_2496	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_2499	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THTE_2507	COG0443	Heat shock 70 kDa protein
THTE_2508	COG0443	Heat shock 70 kDa protein
THTE_2510	COG0066	3-isopropylmalate dehydratase activity
THTE_2511	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THTE_2514	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THTE_2519	COG1606	tRNA processing
THTE_2522	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTE_2526	COG0517	IMP dehydrogenase activity
THTE_2529	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THTE_2537	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THTE_2539	COG0133	tryptophan synthase activity
THTE_2540	COG0159	tryptophan synthase activity
THTE_2541	COG0137	argininosuccinate synthase activity
THTE_2543	COG4935	Belongs to the peptidase S8 family
THTE_2543	COG1404	Belongs to the peptidase S8 family
THTE_2545	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THTE_2550	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THTE_2551	COG0512	Glutamine amidotransferase of anthranilate synthase
THTE_2551	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THTE_2553	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THTE_2559	COG2204	response regulator
THTE_2560	COG0457	Tetratricopeptide repeat
THTE_2569	COG2610	gluconate transmembrane transporter activity
THTE_2573	COG0673	inositol 2-dehydrogenase activity
THTE_2575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THTE_2577	COG3119	arylsulfatase activity
THTE_2579	COG0424	maF-like protein
THTE_2580	COG0776	regulation of translation
THTE_2582	COG0535	radical SAM domain protein
THTE_2591	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THTE_2592	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_2593	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THTE_2594	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_2598	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
THTE_2599	COG1312	Catalyzes the dehydration of D-mannonate
THTE_2609	COG0537	adenosine 5'-monophosphoramidase activity
THTE_2611	COG0745	RESPONSE REGULATOR receiver
THTE_2615	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THTE_2617	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THTE_2618	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THTE_2620	COG4864	UPF0365 protein
THTE_2621	COG0673	inositol 2-dehydrogenase activity
THTE_2626	COG4232	protein-disulfide reductase activity
THTE_2629	COG0205	6-phosphofructokinase activity
THTE_2631	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THTE_2632	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_2633	COG1459	type II secretion system
THTE_2636	COG0745	RESPONSE REGULATOR receiver
THTE_2637	COG5002	protein histidine kinase activity
THTE_2650	COG2239	Acts as a magnesium transporter
THTE_2652	COG1104	cysteine desulfurase activity
THTE_2653	COG1164	Oligoendopeptidase f
THTE_2666	COG1187	pseudouridine synthase activity
THTE_2667	COG0543	2 iron, 2 sulfur cluster binding
THTE_2673	COG0673	inositol 2-dehydrogenase activity
THTE_2676	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
THTE_2679	COG3119	arylsulfatase activity
THTE_2680	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THTE_2681	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THTE_2688	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THTE_2689	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THTE_2713	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THTE_2733	COG0617	tRNA 3'-terminal CCA addition
THTE_2735	COG0446	pyridine nucleotide-disulphide oxidoreductase
THTE_2735	COG1902	pentaerythritol trinitrate reductase activity
THTE_2739	COG0584	glycerophosphoryl diester phosphodiesterase
THTE_2742	COG0705	Rhomboid family
THTE_2744	COG1073	alpha beta
THTE_2749	COG0758	DNA mediated transformation
THTE_2749	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THTE_2764	COG0693	protein deglycase activity
THTE_2768	COG0406	alpha-ribazole phosphatase activity
THTE_2769	COG3119	arylsulfatase activity
THTE_2771	COG3409	Peptidoglycan-binding domain 1 protein
THTE_2771	COG3267	Type II secretory pathway component ExeA
THTE_2773	COG0135	phosphoribosylanthranilate isomerase activity
THTE_2780	COG1192	Involved in chromosome partitioning
THTE_2781	COG1475	DNA binding
THTE_2786	COG1082	Xylose isomerase domain protein TIM barrel
THTE_2790	COG2252	PERMEase
THTE_2792	COG4284	Utp--glucose-1-phosphate uridylyltransferase
THTE_2795	COG0673	inositol 2-dehydrogenase activity
THTE_2808	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THTE_2817	COG0840	transmembrane signaling receptor activity
THTE_2823	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THTE_2824	COG0823	Involved in the tonB-independent uptake of proteins
THTE_2824	COG1506	peptidase
THTE_2824	COG4946	Tricorn protease homolog
THTE_2830	COG5434	Belongs to the glycosyl hydrolase 28 family
THTE_2837	COG2197	response regulator
THTE_2844	COG0740	serine-type endopeptidase activity
THTE_2845	COG0740	serine-type endopeptidase activity
THTE_2846	COG0714	Associated with various cellular activities
THTE_2848	COG0432	Pfam Uncharacterised protein family UPF0047
THTE_2851	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
THTE_2855	COG3083	sulfuric ester hydrolase activity
THTE_2857	COG3852	Histidine kinase
THTE_2859	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THTE_2861	COG0204	Acyl-transferase
THTE_2863	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
THTE_2866	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THTE_2871	COG3119	arylsulfatase activity
THTE_2873	COG1082	Xylose isomerase domain protein TIM barrel
THTE_2876	COG0673	inositol 2-dehydrogenase activity
THTE_2889	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THTE_2890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THTE_2896	COG0437	4 iron, 4 sulfur cluster binding
THTE_2903	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
THTE_2904	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
THTE_2904	COG1845	cytochrome c oxidase, subunit III
THTE_2907	COG1845	cytochrome c oxidase, subunit III
THTE_2912	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THTE_2913	COG2267	carboxylic ester hydrolase activity
THTE_2917	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTE_2919	COG0745	RESPONSE REGULATOR receiver
THTE_2929	COG2261	transglycosylase associated protein
THTE_2944	COG2815	serine threonine protein kinase
THTE_2944	COG0515	serine threonine protein kinase
THTE_2949	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
THTE_2952	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THTE_2953	COG0484	heat shock protein binding
THTE_2963	COG2815	serine threonine protein kinase
THTE_2963	COG0515	serine threonine protein kinase
THTE_2965	COG3119	arylsulfatase activity
THTE_2971	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
THTE_2973	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_2980	COG2204	response regulator
THTE_2989	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_2991	COG0799	negative regulation of ribosome biogenesis
THTE_2992	COG0018	arginyl-trna synthetase
THTE_2995	COG0443	Heat shock 70 kDa protein
THTE_2996	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
THTE_2996	COG1042	CoA-binding domain protein
THTE_2996	COG0045	succinate-CoA ligase (ADP-forming) activity
THTE_3001	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THTE_3002	COG0515	serine threonine protein kinase
THTE_3002	COG2815	serine threonine protein kinase
THTE_3008	COG0446	pyridine nucleotide-disulphide oxidoreductase
THTE_3011	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THTE_3015	COG4956	integral membrane protein (PIN domain superfamily)
THTE_3022	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THTE_3023	COG0569	domain protein
THTE_3024	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTE_3028	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
THTE_3040	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THTE_3048	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
THTE_3050	COG0504	CTP synthase activity
THTE_3051	COG0438	transferase activity, transferring glycosyl groups
THTE_3054	COG0673	inositol 2-dehydrogenase activity
THTE_3055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
THTE_3055	COG0515	serine threonine protein kinase
THTE_3060	COG0300	oxidoreductase activity
THTE_3066	COG0534	Mate efflux family protein
THTE_3067	COG3119	arylsulfatase activity
THTE_3070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THTE_3074	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
THTE_3086	COG2226	methyltransferase
THTE_3087	COG1082	Xylose isomerase domain protein TIM barrel
THTE_3088	COG0095	Lipoate-protein ligase
THTE_3089	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THTE_3090	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THTE_3091	COG0509	glycine decarboxylation via glycine cleavage system
THTE_3097	COG0348	domain, Protein
THTE_3106	COG0352	thiamine-phosphate diphosphorylase activity
THTE_3107	COG3706	GGDEF domain
THTE_3107	COG0745	RESPONSE REGULATOR receiver
THTE_3112	COG0134	indole-3-glycerol-phosphate synthase activity
THTE_3118	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THTE_3120	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THTE_3127	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
THTE_3128	COG0564	pseudouridine synthase activity
THTE_3130	COG0443	Heat shock 70 kDa protein
THTE_3134	COG0542	response to heat
THTE_3135	COG2234	aminopeptidase activity
THTE_3136	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THTE_3140	COG1324	tolerance protein
THTE_3142	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THTE_3143	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THTE_3144	COG4112	unkown
THTE_3145	COG1104	cysteine desulfurase activity
THTE_3146	COG2815	serine threonine protein kinase
THTE_3146	COG0515	serine threonine protein kinase
THTE_3147	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_3153	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THTE_3157	COG0667	Aldo Keto reductase
THTE_3167	COG2165	general secretion pathway protein
THTE_3168	COG1459	type II secretion system
THTE_3169	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
THTE_3172	COG1136	(ABC) transporter
THTE_3174	COG1132	(ABC) transporter
THTE_3177	COG0275	rRNA processing
THTE_3179	COG4656	Part of a membrane complex involved in electron transport
THTE_3182	COG4191	Histidine kinase
THTE_3185	COG1899	peptidyl-lysine modification to peptidyl-hypusine
THTE_3189	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
THTE_3190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THTE_3191	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THTE_3194	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THTE_3198	COG0445	tRNA wobble uridine modification
THTE_3206	COG0601	transmembrane transport
THTE_3207	COG1940	carbohydrate kinase activity
THTE_3214	COG1215	transferase activity, transferring glycosyl groups
THTE_3218	COG3119	arylsulfatase activity
THTE_3219	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THTE_3222	COG3063	Type IV pilus biogenesis stability protein PilW
THTE_3238	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THTE_3243	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THTE_3244	COG4591	ABC-type transport system involved in lipoprotein release permease component
THTE_3245	COG1136	(ABC) transporter
THTE_3247	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_3264	COG3437	response regulator, receiver
THTE_3266	COG0438	transferase activity, transferring glycosyl groups
THTE_3267	COG1446	asparaginase
THTE_3268	COG0784	Response regulator, receiver
THTE_3268	COG2205	protein histidine kinase activity
THTE_3268	COG5002	protein histidine kinase activity
THTE_3271	COG4771	TonB-dependent receptor
THTE_3273	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THTE_3274	COG0154	amidase activity
THTE_3275	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THTE_3277	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
THTE_3285	COG0515	serine threonine protein kinase
THTE_3285	COG2815	serine threonine protein kinase
THTE_3287	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
THTE_3294	COG0142	geranyltranstransferase activity
THTE_3295	COG0544	peptidyl-prolyl cis-trans isomerase activity
THTE_3297	COG0515	serine threonine protein kinase
THTE_3297	COG2815	serine threonine protein kinase
THTE_3305	COG3509	depolymerase
THTE_3305	COG3693	PFAM glycoside hydrolase, family 10
THTE_3308	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_3311	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
THTE_3315	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THTE_3318	COG0840	transmembrane signaling receptor activity
THTE_3335	COG1192	Involved in chromosome partitioning
THTE_3339	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
THTE_3340	COG0038	chloride channel
THTE_3348	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THTE_3349	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THTE_3358	COG0859	PFAM glycosyl transferase family 9
THTE_3363	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THTE_3366	COG0456	acetyltransferase
THTE_3368	COG1120	ATPase activity
THTE_3370	COG0667	Aldo Keto reductase
THTE_3374	COG0126	phosphoglycerate kinase activity
THTE_3375	COG2373	Large extracellular alpha-helical protein
THTE_3381	COG1216	Glycosyl transferase, family 2
THTE_3385	COG0673	inositol 2-dehydrogenase activity
THTE_3389	COG1408	metallophosphoesterase
THTE_3391	COG2363	Small membrane protein
THTE_3394	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
THTE_3401	COG1078	dGTPase activity
THTE_3405	COG0811	peptide transport
THTE_3408	COG4974	Belongs to the 'phage' integrase family
THTE_3412	COG2096	Adenosyltransferase
THTE_3413	COG0004	ammonium transporteR
THTE_3414	COG0347	Belongs to the P(II) protein family
THTE_3416	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
THTE_3421	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THTE_3422	COG0525	valine-tRNA ligase activity
THTE_3423	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
THTE_3431	COG1858	cytochrome C peroxidase
THTE_3433	COG3250	beta-galactosidase activity
THTE_3437	COG1546	Belongs to the CinA family
THTE_3437	COG1058	Belongs to the CinA family
THTE_3461	COG3209	COG3209 Rhs family protein
THTE_3467	COG1943	Transposase
THTE_3475	COG0019	diaminopimelate decarboxylase activity
THTE_3477	COG0469	pyruvate kinase activity
THTE_3478	COG0673	inositol 2-dehydrogenase activity
THTE_3479	COG0673	inositol 2-dehydrogenase activity
THTE_3481	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THTE_3482	COG0049	tRNA binding
THTE_3483	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THTE_3493	COG3119	arylsulfatase activity
THTE_3495	COG0347	Belongs to the P(II) protein family
THTE_3498	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THTE_3505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
THTE_3506	COG1214	PFAM Peptidase M22, glycoprotease
THTE_3509	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THTE_3512	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THTE_3513	COG0081	regulation of translation
THTE_3514	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THTE_3516	COG0222	ribosome binding
THTE_3517	COG0085	RNA polymerase activity
THTE_3518	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THTE_3519	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THTE_3524	COG1073	alpha beta
THTE_3525	COG0456	acetyltransferase
THTE_3526	COG0667	Aldo Keto reductase
THTE_3527	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THTE_3528	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_3529	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THTE_3530	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_3531	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THTE_3536	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THTE_3537	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THTE_3540	COG0598	Magnesium transport protein CorA
THTE_3547	COG2814	Major facilitator Superfamily
THTE_3547	COG2814	Major facilitator Superfamily
THTE_3554	COG0473	3-isopropylmalate dehydrogenase activity
THTE_3560	COG1242	4 iron, 4 sulfur cluster binding
THTE_3562	COG1162	GTPase activity
THTE_3563	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THTE_3564	COG1028	Short-chain dehydrogenase reductase Sdr
THTE_3571	COG0210	DNA helicase
THTE_3572	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THTE_3574	COG3119	arylsulfatase activity
THTE_3585	COG1904	glucuronate isomerase
THTE_3600	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THTE_3601	COG3401	FG-GAP repeat protein
THTE_3602	COG1691	(AIR) carboxylase
THTE_3603	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THTE_3603	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THTE_3604	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THTE_3605	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THTE_3606	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THTE_3608	COG0242	peptide deformylase activity
THTE_3622	COG4221	oxidoreductase activity
THTE_3626	COG0717	Belongs to the dCTP deaminase family
THTE_3627	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THTE_3633	COG0305	Participates in initiation and elongation during chromosome replication
THTE_3643	COG1560	Kdo2-lipid A biosynthetic process
THTE_3647	COG1959	2 iron, 2 sulfur cluster binding
THTE_3655	COG1137	ATPase activity
THTE_3662	COG1192	Involved in chromosome partitioning
THTE_3667	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THTE_3674	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THTE_3675	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
THTE_3676	COG3852	Histidine kinase
THTE_3680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
THTE_3681	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THTE_3681	COG0574	Belongs to the PEP-utilizing enzyme family
THTE_3692	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THTE_3693	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
THTE_3695	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THTE_3696	COG4535	Mg2 and Co2 transporter CorC
THTE_3700	COG2135	peptidase activity
THTE_3702	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THTE_3702	COG0646	methionine synthase
THTE_3706	COG1454	alcohol dehydrogenase
THTE_3710	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THTE_3712	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THTE_3713	COG4589	Belongs to the CDS family
THTE_3714	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THTE_3726	COG3119	arylsulfatase activity
THTE_3732	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THTE_3733	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THTE_3735	COG2379	hydroxypyruvate reductase
THTE_3738	COG1104	cysteine desulfurase activity
THTE_3749	COG0784	Response regulator, receiver
THTE_3749	COG0835	chemotaxis
THTE_3750	COG0515	serine threonine protein kinase
THTE_3750	COG2815	serine threonine protein kinase
THTE_3752	COG1136	(ABC) transporter
THTE_3757	COG0805	protein transport
THTE_3760	COG2084	Dehydrogenase
THTE_3763	COG4864	UPF0365 protein
THTE_3774	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
THTE_3776	COG1082	Xylose isomerase domain protein TIM barrel
THTE_3782	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
THTE_3783	COG1449	Belongs to the glycosyl hydrolase 57 family
THTE_3786	COG1301	dicarboxylic acid transport
THTE_3794	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
THTE_3797	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THTE_3800	COG2226	methyltransferase
THTE_3803	COG0297	glycogen (starch) synthase activity
THTE_3809	COG1129	ABC transporter
THTE_3812	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THTE_3814	COG0483	inositol monophosphate 1-phosphatase activity
THTE_3820	COG0202	RNA polymerase activity
THTE_3826	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
THTE_3827	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THTE_3828	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THTE_3829	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THTE_3830	COG2848	UPF0210 protein
THTE_3838	COG3119	arylsulfatase activity
THTE_3840	COG0673	inositol 2-dehydrogenase activity
THTE_3847	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THTE_3857	COG1032	radical SAM domain protein
THTE_3859	COG0443	Heat shock 70 kDa protein
THTE_3861	COG3118	belongs to the thioredoxin family
THTE_3862	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THTE_3868	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
THTE_3869	COG1053	succinate dehydrogenase
THTE_3870	COG2009	succinate dehydrogenase
THTE_3888	COG1216	Glycosyl transferase, family 2
THTE_3888	COG1442	glycosyl transferase family 8
THTE_3889	COG0438	transferase activity, transferring glycosyl groups
THTE_3890	COG0463	Glycosyl transferase, family 2
THTE_3891	COG0110	maltose O-acetyltransferase activity
THTE_3894	COG0297	glycogen (starch) synthase activity
THTE_3894	COG0438	transferase activity, transferring glycosyl groups
THTE_3896	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THTE_3897	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THTE_3897	COG1796	DNA polymerase
THTE_3898	COG0045	succinate-CoA ligase (ADP-forming) activity
THTE_3900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
THTE_3901	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_3911	COG0463	Glycosyl transferase, family 2
THTE_3914	COG2197	response regulator
THTE_3915	COG2204	response regulator
THTE_3926	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THTE_3936	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THTE_3937	COG0626	cystathionine gamma-synthase activity
THTE_3938	COG0626	cystathionine gamma-synthase activity
THTE_3943	COG2211	Major facilitator Superfamily
THTE_3946	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THTE_3947	COG0484	heat shock protein binding
THTE_3948	COG0459	protein refolding
THTE_3949	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THTE_3951	COG0459	protein refolding
THTE_3958	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THTE_3959	COG1872	DUF167
THTE_3960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THTE_3969	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THTE_3972	COG0788	formyltetrahydrofolate deformylase activity
THTE_3976	COG1063	alcohol dehydrogenase
THTE_3979	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THTE_3980	COG1562	ergosterol biosynthetic process
THTE_3981	COG1562	ergosterol biosynthetic process
THTE_3982	COG1233	COG1233 Phytoene dehydrogenase and related
THTE_3987	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THTE_3992	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
THTE_3994	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
THTE_4000	COG2201	protein-glutamate methylesterase activity
THTE_4001	COG4964	Belongs to the GSP D family
THTE_4010	COG1121	(ABC) transporter
THTE_4011	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THTE_4013	COG0359	binds to the 23S rRNA
THTE_4015	COG0629	single-stranded DNA binding
THTE_4016	COG0360	Binds together with S18 to 16S ribosomal RNA
THTE_4017	COG0193	aminoacyl-tRNA hydrolase activity
THTE_4018	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THTE_4020	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THTE_4032	COG1480	7TM receptor with intracellular HD hydrolase
THTE_4033	COG1702	phosphate starvation-inducible protein PhoH
THTE_4037	COG0473	3-isopropylmalate dehydrogenase activity
THTE_4039	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
THTE_4041	COG2204	response regulator
THTE_4044	COG2249	NAD(P)H dehydrogenase (quinone) activity
THTE_4047	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THTE_4050	COG0612	Peptidase, M16
THTE_4051	COG0612	Peptidase, M16
THTE_4053	COG0571	ribonuclease III activity
THTE_4054	COG0482	sulfurtransferase activity
THTE_4058	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THTE_4058	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THTE_4058	COG1013	pyruvate-flavodoxin oxidoreductase activity
THTE_4058	COG0674	pyruvate-flavodoxin oxidoreductase activity
THTE_4061	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
THTE_4074	COG3209	COG3209 Rhs family protein
THTE_4076	COG3209	COG3209 Rhs family protein
THTE_4078	COG3209	COG3209 Rhs family protein
THTE_4083	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THTE_4092	COG1968	undecaprenyl-diphosphatase activity
THTE_4101	COG0673	inositol 2-dehydrogenase activity
THTE_4104	COG1530	ribonuclease E activity
THTE_4119	COG0714	Associated with various cellular activities
THTE_4129	COG0463	Glycosyl transferase, family 2
THTE_4136	COG0457	Tetratricopeptide repeat
THTE_4138	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THTE_4139	COG2189	Belongs to the N(4) N(6)-methyltransferase family
THTE_4142	COG1309	transcriptional regulator
THTE_4153	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THTE_4157	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THTE_4169	COG1086	Polysaccharide biosynthesis protein
THTE_4177	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THTE_4179	COG0745	RESPONSE REGULATOR receiver
THTE_4179	COG3706	GGDEF domain
THTE_4180	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THTE_4181	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THTE_4188	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THTE_4189	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THTE_4190	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THTE_4191	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THTE_4192	COG0686	Belongs to the AlaDH PNT family
THTE_4194	COG0505	Belongs to the CarA family
THTE_4205	COG4964	Belongs to the GSP D family
THTE_4211	COG0436	Aminotransferase
THTE_4217	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THTE_4222	COG1331	Highly conserved protein containing a thioredoxin domain
THTE_4229	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THTE_4236	COG1160	GTP binding
THTE_4239	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
THTE_4253	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THTE_4258	COG0436	Aminotransferase
THTE_4264	COG1774	PSP1 C-terminal conserved region
THTE_4266	COG2801	Transposase and inactivated derivatives
THTE_4269	COG0445	tRNA wobble uridine modification
THTE_4274	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THTE_4274	COG1754	DNA topoisomerase type I activity
THTE_4278	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THTE_4279	COG1858	cytochrome C peroxidase
THTE_4280	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THTE_4282	COG2198	Histidine kinase
THTE_4282	COG0643	Histidine kinase
THTE_4294	COG0156	8-amino-7-oxononanoate synthase activity
THTE_4296	COG2151	metal-sulfur cluster biosynthetic enzyme
THTE_4298	COG0719	Fe-S assembly protein
THTE_4299	COG0719	Fe-S assembly protein
THTE_4300	COG0396	ATPase activity
THTE_4301	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THTE_4304	COG0733	neurotransmitter:sodium symporter activity
THTE_4308	COG2048	Heterodisulfide reductase, subunit B
THTE_4310	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THTE_4312	COG1941	NADH ubiquinone oxidoreductase 20 kDa subunit
THTE_4313	COG3259	Nickel-dependent hydrogenase
THTE_4317	COG1203	CRISPR-associated helicase, Cas3
THTE_4319	COG1518	maintenance of DNA repeat elements
THTE_4320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THTE_4326	COG2154	pterin-4-alpha-carbinolamine dehydratase
THTE_4332	COG0828	Belongs to the bacterial ribosomal protein bS21 family
THTE_4352	COG1706	bacterial-type flagellum-dependent cell motility
THTE_4353	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THTE_4355	COG4786	Flagellar basal body rod
THTE_4356	COG4786	Flagellar basal body rod
THTE_4360	COG0181	hydroxymethylbilane synthase activity
THTE_4363	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
THTE_4363	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THTE_4363	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
THTE_4364	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
THTE_4365	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THTE_4366	COG0667	Aldo Keto reductase
THTE_4368	COG0811	peptide transport
THTE_4369	COG0848	biopolymer transport protein
THTE_4372	COG2706	6-phosphogluconolactonase activity
THTE_4377	COG0698	ribose 5-phosphate isomerase
THTE_4380	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THTE_4389	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THTE_4395	COG0352	thiamine-phosphate diphosphorylase activity
THTE_4395	COG0351	phosphomethylpyrimidine kinase
THTE_4397	COG0438	transferase activity, transferring glycosyl groups
THTE_4405	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THTE_4410	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THTE_4411	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THTE_4446	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THTE_4447	COG0632	four-way junction helicase activity
THTE_4452	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THTE_4453	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THTE_4456	COG0113	porphobilinogen synthase activity
THTE_4460	COG1881	PFAM PEBP family protein
THTE_4462	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THTE_4464	COG0602	queuosine metabolic process
THTE_4469	COG2088	sporulation resulting in formation of a cellular spore
THTE_4470	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THTE_4478	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
THTE_4485	COG0012	GTP binding
THTE_4491	COG0673	inositol 2-dehydrogenase activity