locus-tag	class	description
HJD18_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HJD18_00010	COG0592	DNA-directed DNA polymerase activity
HJD18_00015	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HJD18_00025	COG0187	DNA topoisomerase II activity
HJD18_00030	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HJD18_00035	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HJD18_00055	COG0077	Prephenate dehydratase
HJD18_00075	COG1716	ATPase activity
HJD18_00090	COG0768	penicillin binding
HJD18_00095	COG0515	serine threonine protein kinase
HJD18_00095	COG2815	serine threonine protein kinase
HJD18_00100	COG1181	Belongs to the D-alanine--D-alanine ligase family
HJD18_00120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HJD18_00175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HJD18_00205	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HJD18_00225	COG0714	Associated with various cellular activities
HJD18_00250	COG2816	NAD+ diphosphatase activity
HJD18_00255	COG0730	response to heat
HJD18_00280	COG2080	2 iron, 2 sulfur cluster binding
HJD18_00285	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HJD18_00290	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HJD18_00305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HJD18_00335	COG1714	RDD family
HJD18_00340	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HJD18_00345	COG0321	lipoyl(octanoyl) transferase activity
HJD18_00355	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD18_00360	COG0022	dehydrogenase e1 component
HJD18_00365	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HJD18_00410	COG0352	thiamine-phosphate diphosphorylase activity
HJD18_00415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD18_00415	COG2022	thiamine diphosphate biosynthetic process
HJD18_00425	COG2022	thiamine diphosphate biosynthetic process
HJD18_00430	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HJD18_00440	COG4208	sulfate ABC transporter
HJD18_00445	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HJD18_00455	COG0745	RESPONSE REGULATOR receiver
HJD18_00460	COG0642	Histidine kinase
HJD18_00480	COG1132	(ABC) transporter
HJD18_00485	COG0515	serine threonine protein kinase
HJD18_00490	COG0138	bifunctional purine biosynthesis protein purh
HJD18_00495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HJD18_00500	COG0514	ATP-dependent DNA helicase (RecQ)
HJD18_00505	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HJD18_00540	COG0515	serine threonine protein kinase
HJD18_00540	COG2815	serine threonine protein kinase
HJD18_00575	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HJD18_00590	COG0047	phosphoribosylformylglycinamidine synthase activity
HJD18_00595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HJD18_00600	COG3551	Protein conserved in bacteria
HJD18_00605	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HJD18_00620	COG2226	methyltransferase
HJD18_00625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HJD18_00630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HJD18_00635	COG0151	Belongs to the GarS family
HJD18_00640	COG4274	PFAM GYD family protein
HJD18_00655	COG0542	response to heat
HJD18_00670	COG0789	Transcriptional regulator
HJD18_00675	COG0484	heat shock protein binding
HJD18_00680	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HJD18_00685	COG0443	Heat shock 70 kDa protein
HJD18_00705	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HJD18_00725	COG0438	transferase activity, transferring glycosyl groups
HJD18_00735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HJD18_00755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HJD18_00770	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HJD18_00780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD18_00795	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_00800	COG1131	(ABC) transporter
HJD18_00820	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HJD18_00825	COG0181	hydroxymethylbilane synthase activity
HJD18_00830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HJD18_00830	COG1587	Uroporphyrinogen-III synthase
HJD18_00840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HJD18_00840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HJD18_00850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJD18_00860	COG0330	HflC and HflK could
HJD18_00900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HJD18_00905	COG0022	dehydrogenase e1 component
HJD18_00905	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD18_00910	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD18_00935	COG0601	transmembrane transport
HJD18_00955	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HJD18_00965	COG0546	phosphoglycolate phosphatase activity
HJD18_00990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HJD18_01010	COG0745	RESPONSE REGULATOR receiver
HJD18_01015	COG5002	protein histidine kinase activity
HJD18_01020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HJD18_01040	COG0360	Binds together with S18 to 16S ribosomal RNA
HJD18_01045	COG0629	single-stranded DNA binding
HJD18_01050	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HJD18_01055	COG0359	binds to the 23S rRNA
HJD18_01060	COG0305	Participates in initiation and elongation during chromosome replication
HJD18_01065	COG1484	DNA-dependent DNA replication
HJD18_01070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HJD18_01075	COG0439	Biotin carboxylase
HJD18_01095	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_01110	COG0242	peptide deformylase activity
HJD18_01130	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
HJD18_01135	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HJD18_01150	COG2197	response regulator
HJD18_01160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJD18_01165	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HJD18_01180	COG3551	Protein conserved in bacteria
HJD18_01190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD18_01195	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD18_01200	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD18_01205	COG0649	NAD binding
HJD18_01220	COG1034	ATP synthesis coupled electron transport
HJD18_01225	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HJD18_01230	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD18_01235	COG0839	Belongs to the complex I subunit 6 family
HJD18_01240	COG0713	ATP synthesis coupled electron transport
HJD18_01255	COG1007	ATP synthesis coupled electron transport
HJD18_01275	COG0477	Major facilitator Superfamily
HJD18_01295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HJD18_01305	COG1132	(ABC) transporter
HJD18_01330	COG0583	DNA-binding transcription factor activity
HJD18_01350	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD18_01350	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD18_01360	COG0431	NADPH-dependent FMN reductase
HJD18_01380	COG1595	DNA-templated transcription, initiation
HJD18_01390	COG0450	alkyl hydroperoxide reductase
HJD18_01410	COG0596	Alpha beta hydrolase
HJD18_01415	COG1078	dGTPase activity
HJD18_01430	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HJD18_01435	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HJD18_01450	COG1648	precorrin-2 dehydrogenase activity
HJD18_01450	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HJD18_01455	COG0667	Aldo Keto reductase
HJD18_01470	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HJD18_01475	COG0477	Major facilitator Superfamily
HJD18_01480	COG0470	DNA polymerase III
HJD18_01485	COG5002	protein histidine kinase activity
HJD18_01490	COG0745	RESPONSE REGULATOR receiver
HJD18_01510	COG0745	RESPONSE REGULATOR receiver
HJD18_01525	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HJD18_01550	COG1607	acyl-coa hydrolase
HJD18_01570	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HJD18_01580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJD18_01645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HJD18_01655	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_01690	COG2076	Multidrug Resistance protein
HJD18_01700	COG0179	Fumarylacetoacetate (FAA) hydrolase
HJD18_01705	COG1309	transcriptional regulator
HJD18_01710	COG3634	alkyl hydroperoxide reductase activity
HJD18_01740	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HJD18_01760	COG0489	protein tyrosine kinase activity
HJD18_01800	COG0297	glycogen (starch) synthase activity
HJD18_01805	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HJD18_01850	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HJD18_01860	COG0250	Participates in transcription elongation, termination and antitermination
HJD18_01870	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJD18_01890	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HJD18_01895	COG0667	Aldo Keto reductase
HJD18_01905	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HJD18_01910	COG0081	regulation of translation
HJD18_01920	COG2226	methyltransferase
HJD18_01925	COG0640	Transcriptional regulator
HJD18_01930	COG0798	PFAM Bile acid sodium symporter
HJD18_01935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJD18_01940	COG1309	transcriptional regulator
HJD18_01990	COG0076	glutamate decarboxylase activity
HJD18_02005	COG2197	response regulator
HJD18_02055	COG0740	serine-type endopeptidase activity
HJD18_02065	COG1131	(ABC) transporter
HJD18_02075	COG2197	response regulator
HJD18_02085	COG0640	Transcriptional regulator
HJD18_02095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HJD18_02100	COG0222	ribosome binding
HJD18_02110	COG0085	RNA polymerase activity
HJD18_02115	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HJD18_02140	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HJD18_02145	COG0049	tRNA binding
HJD18_02165	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HJD18_02170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HJD18_02175	COG0051	transcription antitermination factor activity, RNA binding
HJD18_02180	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HJD18_02185	COG0088	Forms part of the polypeptide exit tunnel
HJD18_02190	COG0089	rRNA binding
HJD18_02195	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HJD18_02200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HJD18_02205	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HJD18_02210	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HJD18_02215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HJD18_02220	COG0255	Belongs to the universal ribosomal protein uL29 family
HJD18_02225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HJD18_02230	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HJD18_02235	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HJD18_02240	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HJD18_02245	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HJD18_02250	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HJD18_02255	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HJD18_02265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HJD18_02270	COG1841	ribosomal large subunit assembly
HJD18_02275	COG0200	Binds to the 23S rRNA
HJD18_02295	COG0563	adenylate kinase activity
HJD18_02310	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HJD18_02315	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HJD18_02320	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HJD18_02325	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HJD18_02330	COG0202	RNA polymerase activity
HJD18_02335	COG0203	ribosomal protein L17
HJD18_02340	COG1335	isochorismatase
HJD18_02350	COG0101	tRNA pseudouridine synthase activity
HJD18_02360	COG3842	ATPase activity
HJD18_02365	COG1178	ABC-type Fe3 transport system permease component
HJD18_02400	COG4221	oxidoreductase activity
HJD18_02415	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HJD18_02420	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HJD18_02500	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HJD18_02505	COG0521	Mo-molybdopterin cofactor biosynthetic process
HJD18_02510	COG0315	cyclic pyranopterin monophosphate synthase activity
HJD18_02520	COG0166	Belongs to the GPI family
HJD18_02525	COG0303	'Molybdopterin
HJD18_02535	COG0604	alcohol dehydrogenase
HJD18_02545	COG4941	Belongs to the sigma-70 factor family
HJD18_02565	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HJD18_02570	COG0596	Alpha beta hydrolase
HJD18_02575	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HJD18_02590	COG3387	PFAM Glycoside hydrolase 15-related
HJD18_02600	COG0477	Major facilitator Superfamily
HJD18_02620	COG0725	ABC transporter, periplasmic molybdate-binding protein
HJD18_02640	COG1929	Belongs to the glycerate kinase type-1 family
HJD18_02650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HJD18_02685	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HJD18_02685	COG3608	succinylglutamate desuccinylase aspartoacylase
HJD18_02690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HJD18_02700	COG2132	Multicopper oxidase
HJD18_02725	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HJD18_02750	COG1937	Protein conserved in bacteria
HJD18_02785	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD18_02795	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HJD18_02805	COG0713	ATP synthesis coupled electron transport
HJD18_02810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJD18_02815	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HJD18_02820	COG1007	ATP synthesis coupled electron transport
HJD18_02830	COG0640	Transcriptional regulator
HJD18_02920	COG1773	rubredoxin
HJD18_02955	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HJD18_02960	COG1024	Enoyl-CoA hydratase
HJD18_02965	COG0511	ligase activity, forming carbon-carbon bonds
HJD18_02985	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_02990	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_03000	COG0318	PFAM AMP-dependent synthetase and ligase
HJD18_03010	COG1960	acyl-CoA dehydrogenase activity
HJD18_03015	COG1960	acyl-CoA dehydrogenase activity
HJD18_03020	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HJD18_03025	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD18_03030	COG3246	L-lysine catabolic process to acetate
HJD18_03035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HJD18_03070	COG1597	lipid kinase activity
HJD18_03080	COG4589	Belongs to the CDS family
HJD18_03095	COG1191	sigma factor activity
HJD18_03110	COG2195	Cleaves the N-terminal amino acid of tripeptides
HJD18_03120	COG3383	formate dehydrogenase (NAD+) activity
HJD18_03120	COG0243	molybdopterin cofactor binding
HJD18_03125	COG0243	molybdopterin cofactor binding
HJD18_03125	COG3383	formate dehydrogenase (NAD+) activity
HJD18_03130	COG0437	4 iron, 4 sulfur cluster binding
HJD18_03150	COG0709	Synthesizes selenophosphate from selenide and ATP
HJD18_03165	COG2267	carboxylic ester hydrolase activity
HJD18_03200	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_03220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD18_03230	COG3527	Alpha-acetolactate decarboxylase
HJD18_03255	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HJD18_03260	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HJD18_03265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HJD18_03285	COG3300	MHYT domain
HJD18_03285	COG5001	Diguanylate cyclase
HJD18_03355	COG1690	Belongs to the RtcB family
HJD18_03415	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJD18_03450	COG1090	epimerase
HJD18_03480	COG2186	Transcriptional regulator
HJD18_03535	COG2205	protein histidine kinase activity
HJD18_03540	COG0745	RESPONSE REGULATOR receiver
HJD18_03550	COG1136	(ABC) transporter
HJD18_03600	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HJD18_03605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HJD18_03610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HJD18_03615	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD18_03620	COG0583	DNA-binding transcription factor activity
HJD18_03635	COG2072	flavoprotein involved in K transport
HJD18_03640	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_03650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HJD18_03655	COG1116	anion transmembrane transporter activity
HJD18_03660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD18_03705	COG0589	response to stress
HJD18_03745	COG2197	response regulator
HJD18_03765	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_03785	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
HJD18_03790	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
HJD18_03795	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
HJD18_03800	COG2205	protein histidine kinase activity
HJD18_03805	COG0596	Alpha beta hydrolase
HJD18_03820	COG1295	ribonuclease BN
HJD18_03825	COG0739	heme binding
HJD18_03825	COG1196	nuclear chromosome segregation
HJD18_03825	COG0741	lytic transglycosylase activity
HJD18_03850	COG1320	monovalent cation:proton antiporter activity
HJD18_03865	COG0651	ATP synthesis coupled electron transport
HJD18_03870	COG1006	Multisubunit Na H antiporter MnhC subunit
HJD18_03880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HJD18_03880	COG2111	Na H antiporter
HJD18_03905	COG1937	Protein conserved in bacteria
HJD18_03925	COG1191	sigma factor activity
HJD18_03950	COG1295	ribonuclease BN
HJD18_03975	COG1309	transcriptional regulator
HJD18_03980	COG0668	transmembrane transport
HJD18_03990	COG0789	Transcriptional regulator
HJD18_04000	COG1131	(ABC) transporter
HJD18_04005	COG0842	Transport permease protein
HJD18_04085	COG2755	lipolytic protein G-D-S-L family
HJD18_04085	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HJD18_04090	COG3408	Glycogen debranching enzyme
HJD18_04090	COG3119	arylsulfatase activity
HJD18_04105	COG2223	nitrite transmembrane transporter activity
HJD18_04115	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HJD18_04135	COG0681	Belongs to the peptidase S26 family
HJD18_04140	COG0693	protein deglycase activity
HJD18_04170	COG2814	Major facilitator Superfamily
HJD18_04180	COG0628	permease
HJD18_04190	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJD18_04195	COG1366	Belongs to the anti-sigma-factor antagonist family
HJD18_04210	COG0668	transmembrane transport
HJD18_04215	COG1309	transcriptional regulator
HJD18_04230	COG1307	EDD domain protein, DegV family
HJD18_04235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD18_04250	COG0488	(ABC) transporter
HJD18_04255	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HJD18_04280	COG1410	methionine synthase
HJD18_04280	COG0646	methionine synthase
HJD18_04290	COG0346	lactoylglutathione lyase activity
HJD18_04295	COG0277	FAD linked oxidase domain protein
HJD18_04300	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_04325	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HJD18_04330	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HJD18_04335	COG1127	ABC transporter
HJD18_04370	COG0156	8-amino-7-oxononanoate synthase activity
HJD18_04375	COG0456	acetyltransferase
HJD18_04390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HJD18_04395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HJD18_04400	COG1116	anion transmembrane transporter activity
HJD18_04415	COG0542	response to heat
HJD18_04425	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HJD18_04430	COG0512	Glutamine amidotransferase of anthranilate synthase
HJD18_04430	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HJD18_04440	COG0347	Belongs to the P(II) protein family
HJD18_04445	COG0004	ammonium transporteR
HJD18_04450	COG1234	tRNA 3'-trailer cleavage
HJD18_04460	COG2203	Gaf domain
HJD18_04460	COG3706	GGDEF domain
HJD18_04460	COG4251	negative regulation of phosphorylation
HJD18_04460	COG5001	Diguanylate cyclase
HJD18_04470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HJD18_04475	COG0183	Belongs to the thiolase family
HJD18_04495	COG0579	oxidoreductase
HJD18_04500	COG1793	dna ligase
HJD18_04535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD18_04540	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HJD18_04620	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJD18_04630	COG1733	regulation of RNA biosynthetic process
HJD18_04645	COG0003	Pfam Anion-transporting ATPase
HJD18_04650	COG1192	Involved in chromosome partitioning
HJD18_04655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HJD18_04660	COG0405	Gamma-glutamyltransferase
HJD18_04695	COG0110	maltose O-acetyltransferase activity
HJD18_04710	COG1960	acyl-CoA dehydrogenase activity
HJD18_04720	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HJD18_04725	COG0183	Belongs to the thiolase family
HJD18_04735	COG0784	Response regulator, receiver
HJD18_04735	COG2205	protein histidine kinase activity
HJD18_04735	COG5002	protein histidine kinase activity
HJD18_04740	COG0745	RESPONSE REGULATOR receiver
HJD18_04755	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HJD18_04775	COG1309	transcriptional regulator
HJD18_04780	COG0254	rRNA binding
HJD18_04785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HJD18_04790	COG2890	protein-(glutamine-N5) methyltransferase activity
HJD18_04805	COG0698	ribose 5-phosphate isomerase
HJD18_04810	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HJD18_04820	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HJD18_04830	COG0356	it plays a direct role in the translocation of protons across the membrane
HJD18_04840	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HJD18_04845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HJD18_04850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HJD18_04855	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HJD18_04860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HJD18_04865	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HJD18_04875	COG1316	TRANSCRIPTIONal
HJD18_04880	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HJD18_04890	COG2222	sugar isomerase
HJD18_04905	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HJD18_04910	COG5002	protein histidine kinase activity
HJD18_04920	COG0083	homoserine kinase activity
HJD18_04925	COG1192	Involved in chromosome partitioning
HJD18_04940	COG0768	penicillin binding
HJD18_04945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HJD18_04950	COG1733	regulation of RNA biosynthetic process
HJD18_04960	COG1074	ATP-dependent DNA helicase activity
HJD18_05000	COG2151	metal-sulfur cluster biosynthetic enzyme
HJD18_05015	COG2366	antibiotic biosynthetic process
HJD18_05030	COG2234	aminopeptidase activity
HJD18_05040	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HJD18_05070	COG0719	Fe-S assembly protein
HJD18_05075	COG0719	Fe-S assembly protein
HJD18_05080	COG2146	nitrite reductase [NAD(P)H] activity
HJD18_05105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HJD18_05110	COG0396	ATPase activity
HJD18_05115	COG1959	2 iron, 2 sulfur cluster binding
HJD18_05120	COG2197	response regulator
HJD18_05130	COG0501	Belongs to the peptidase M48B family
HJD18_05145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HJD18_05150	COG1126	abc transporter atp-binding protein
HJD18_05155	COG0765	amino acid transport
HJD18_05160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HJD18_05225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HJD18_05250	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HJD18_05275	COG1620	l-lactate permease
HJD18_05280	COG0277	FAD linked oxidase domain protein
HJD18_05285	COG0277	FAD linked oxidase domain protein
HJD18_05290	COG0247	lactate metabolic process
HJD18_05295	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HJD18_05310	COG0312	modulator of DNA gyrase
HJD18_05315	COG0312	modulator of DNA gyrase
HJD18_05360	COG1268	BioY protein
HJD18_05380	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJD18_05425	COG5001	Diguanylate cyclase
HJD18_05425	COG5002	protein histidine kinase activity
HJD18_05430	COG4221	oxidoreductase activity
HJD18_05435	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HJD18_05465	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HJD18_05485	COG0174	glutamine synthetase
HJD18_05520	COG0346	lactoylglutathione lyase activity
HJD18_05535	COG2814	Major facilitator Superfamily
HJD18_05545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HJD18_05550	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD18_05560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD18_05565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HJD18_05585	COG0045	succinate-CoA ligase (ADP-forming) activity
HJD18_05590	COG2261	transglycosylase associated protein
HJD18_05595	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
HJD18_05600	COG2301	Belongs to the HpcH HpaI aldolase family
HJD18_05625	COG0154	amidase activity
HJD18_05640	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD18_05640	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD18_05660	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HJD18_05670	COG0583	DNA-binding transcription factor activity
HJD18_05680	COG0604	alcohol dehydrogenase
HJD18_05695	COG0354	folic acid binding
HJD18_05705	COG1914	H( )-stimulated, divalent metal cation uptake system
HJD18_05710	COG3300	MHYT domain
HJD18_05710	COG5001	Diguanylate cyclase
HJD18_05725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HJD18_05730	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HJD18_05735	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HJD18_05740	COG0778	Nitroreductase
HJD18_05740	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
HJD18_05745	COG1920	GTP binding
HJD18_05750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HJD18_05775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD18_05785	COG0402	S-adenosylhomocysteine deaminase activity
HJD18_05790	COG0405	Gamma-glutamyltransferase
HJD18_05795	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD18_05815	COG2135	peptidase activity
HJD18_05870	COG0076	glutamate decarboxylase activity
HJD18_05915	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HJD18_05925	COG4424	Sulfotransferase
HJD18_05930	COG1061	Type III restriction enzyme res subunit
HJD18_05955	COG0531	amino acid
HJD18_05965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HJD18_05970	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_05975	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_05990	COG0475	glutathione-regulated potassium exporter activity
HJD18_06020	COG0435	Glutathione S-transferase
HJD18_06090	COG2197	response regulator
HJD18_06110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJD18_06125	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_06130	COG2186	Transcriptional regulator
HJD18_06135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HJD18_06160	COG0076	glutamate decarboxylase activity
HJD18_06175	COG2124	cytochrome p450
HJD18_06180	COG0174	glutamine synthetase
HJD18_06205	COG3845	ABC transporter
HJD18_06215	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HJD18_06235	COG0745	RESPONSE REGULATOR receiver
HJD18_06260	COG0028	Belongs to the TPP enzyme family
HJD18_06290	COG0275	rRNA processing
HJD18_06305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HJD18_06310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HJD18_06315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HJD18_06320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HJD18_06325	COG0772	Belongs to the SEDS family
HJD18_06330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HJD18_06335	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HJD18_06350	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HJD18_06355	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HJD18_06360	COG0509	glycine decarboxylation via glycine cleavage system
HJD18_06370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HJD18_06375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HJD18_06400	COG0180	Tryptophanyl-tRNA synthetase
HJD18_06405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HJD18_06410	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HJD18_06415	COG1187	pseudouridine synthase activity
HJD18_06425	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HJD18_06430	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HJD18_06435	COG0287	Prephenate dehydrogenase
HJD18_06440	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HJD18_06445	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HJD18_06450	COG1160	GTP binding
HJD18_06465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HJD18_06470	COG0242	peptide deformylase activity
HJD18_06475	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HJD18_06485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HJD18_06490	COG3263	regulation of cellular component size
HJD18_06510	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD18_06510	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HJD18_06515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HJD18_06520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HJD18_06540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HJD18_06545	COG0742	ribosomal rna small subunit methyltransferase
HJD18_06550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HJD18_06560	COG4106	trans-aconitate 2-methyltransferase activity
HJD18_06575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HJD18_06580	COG0416	fatty acid biosynthetic process
HJD18_06585	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HJD18_06590	COG0571	ribonuclease III activity
HJD18_06595	COG1196	nuclear chromosome segregation
HJD18_06600	COG0552	protein localization to endoplasmic reticulum
HJD18_06605	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HJD18_06605	COG1672	PFAM Archaeal ATPase
HJD18_06620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HJD18_06630	COG1837	Belongs to the UPF0109 family
HJD18_06635	COG0336	Belongs to the RNA methyltransferase TrmD family
HJD18_06640	COG0335	large ribosomal subunit rRNA binding
HJD18_06645	COG0681	Belongs to the peptidase S26 family
HJD18_06650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HJD18_06655	COG0792	nuclease activity
HJD18_06665	COG0758	DNA mediated transformation
HJD18_06670	COG0351	phosphomethylpyrimidine kinase
HJD18_06685	COG0129	dihydroxy-acid dehydratase activity
HJD18_06695	COG0204	Acyl-transferase
HJD18_06710	COG4974	Belongs to the 'phage' integrase family
HJD18_06715	COG1191	sigma factor activity
HJD18_06760	COG1121	(ABC) transporter
HJD18_06765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HJD18_06770	COG0735	belongs to the Fur family
HJD18_06790	COG0542	response to heat
HJD18_06805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HJD18_06810	COG0443	Heat shock 70 kDa protein
HJD18_06815	COG0583	DNA-binding transcription factor activity
HJD18_06820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HJD18_06825	COG2259	Doxx family
HJD18_06855	COG0438	transferase activity, transferring glycosyl groups
HJD18_06905	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HJD18_06915	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HJD18_06930	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HJD18_06940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HJD18_06945	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HJD18_06950	COG0072	phenylalanine-tRNA ligase activity
HJD18_06950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJD18_06955	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HJD18_06960	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HJD18_06965	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HJD18_06970	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HJD18_06995	COG0438	transferase activity, transferring glycosyl groups
HJD18_07005	COG0297	glycogen (starch) synthase activity
HJD18_07015	COG2244	polysaccharide biosynthetic process
HJD18_07035	COG0489	protein tyrosine kinase activity
HJD18_07065	COG0297	glycogen (starch) synthase activity
HJD18_07090	COG0489	protein tyrosine kinase activity
HJD18_07095	COG3764	Sortase (surface protein transpeptidase)
HJD18_07100	COG0137	argininosuccinate synthase activity
HJD18_07120	COG0784	Response regulator, receiver
HJD18_07120	COG3437	response regulator, receiver
HJD18_07135	COG3706	GGDEF domain
HJD18_07165	COG2205	protein histidine kinase activity
HJD18_07180	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HJD18_07185	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HJD18_07190	COG2909	trisaccharide binding
HJD18_07210	COG1045	serine acetyltransferase
HJD18_07220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HJD18_07240	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HJD18_07245	COG0154	amidase activity
HJD18_07255	COG1252	NADH dehydrogenase
HJD18_07265	COG0463	Glycosyl transferase, family 2
HJD18_07280	COG0028	Belongs to the TPP enzyme family
HJD18_07285	COG0440	acetolactate synthase activity
HJD18_07310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HJD18_07320	COG4948	Mandelate Racemase Muconate Lactonizing
HJD18_07330	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HJD18_07340	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HJD18_07360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HJD18_07380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HJD18_07390	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HJD18_07395	COG0066	3-isopropylmalate dehydratase activity
HJD18_07400	COG4106	trans-aconitate 2-methyltransferase activity
HJD18_07405	COG0473	3-isopropylmalate dehydrogenase activity
HJD18_07415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HJD18_07420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HJD18_07425	COG0165	Argininosuccinate lyase
HJD18_07430	COG2094	Belongs to the DNA glycosylase MPG family
HJD18_07435	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HJD18_07440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HJD18_07465	COG0587	DNA-directed DNA polymerase activity
HJD18_07505	COG0559	Belongs to the binding-protein-dependent transport system permease family
HJD18_07510	COG0538	isocitrate dehydrogenase activity
HJD18_07525	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HJD18_07530	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HJD18_07535	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HJD18_07540	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HJD18_07545	COG0131	Imidazoleglycerol-phosphate dehydratase
HJD18_07550	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HJD18_07555	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HJD18_07565	COG0107	imidazoleglycerol-phosphate synthase activity
HJD18_07575	COG0517	IMP dehydrogenase activity
HJD18_07575	COG0617	tRNA 3'-terminal CCA addition
HJD18_07575	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HJD18_07585	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HJD18_07590	COG1799	cell septum assembly
HJD18_07595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HJD18_07600	COG0762	integral membrane protein
HJD18_07605	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HJD18_07610	COG0564	pseudouridine synthase activity
HJD18_07615	COG0052	Belongs to the universal ribosomal protein uS2 family
HJD18_07620	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HJD18_07625	COG0528	UMP kinase activity
HJD18_07630	COG0233	cytoplasmic translational termination
HJD18_07635	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HJD18_07645	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HJD18_07650	COG0750	zinc metalloprotease
HJD18_07665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HJD18_07670	COG0540	Belongs to the ATCase OTCase family
HJD18_07675	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HJD18_07685	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HJD18_07690	COG0543	2 iron, 2 sulfur cluster binding
HJD18_07695	COG0167	dihydroorotate dehydrogenase activity
HJD18_07705	COG0194	GDP metabolic process
HJD18_07725	COG1490	D-aminoacyl-tRNA deacylase activity
HJD18_07730	COG0779	Required for maturation of 30S ribosomal subunits
HJD18_07735	COG0195	Participates in both transcription termination and antitermination
HJD18_07740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HJD18_07745	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HJD18_07755	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HJD18_07765	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HJD18_07785	COG1185	polyribonucleotide nucleotidyltransferase activity
HJD18_07790	COG0612	Peptidase, M16
HJD18_07795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HJD18_07800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HJD18_07805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HJD18_07815	COG2205	protein histidine kinase activity
HJD18_07825	COG1674	ftsk spoiiie
HJD18_07840	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HJD18_07845	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HJD18_07855	COG1418	mRNA catabolic process
HJD18_07870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HJD18_07875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HJD18_07880	COG0436	Aminotransferase
HJD18_07885	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HJD18_07890	COG3795	YCII-related domain
HJD18_07895	COG4941	Belongs to the sigma-70 factor family
HJD18_07900	COG0076	glutamate decarboxylase activity
HJD18_07905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HJD18_07910	COG0756	dUTP diphosphatase activity
HJD18_07920	COG2072	flavoprotein involved in K transport
HJD18_07925	COG3442	glutamine amidotransferase
HJD18_07935	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HJD18_07940	COG2226	methyltransferase
HJD18_07950	COG2267	carboxylic ester hydrolase activity
HJD18_07980	COG1472	Belongs to the glycosyl hydrolase 3 family
HJD18_08000	COG1678	Uncharacterized ACR, COG1678
HJD18_08010	COG0785	Cytochrome C biogenesis protein
HJD18_08025	COG2132	Multicopper oxidase
HJD18_08035	COG0248	Ppx GppA phosphatase
HJD18_08065	COG1716	ATPase activity
HJD18_08075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HJD18_08080	COG0442	prolyl-tRNA aminoacylation
HJD18_08100	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HJD18_08105	COG2267	carboxylic ester hydrolase activity
HJD18_08110	COG1234	tRNA 3'-trailer cleavage
HJD18_08210	COG1002	Type II restriction enzyme, methylase subunits
HJD18_08235	COG0154	amidase activity
HJD18_08250	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJD18_08255	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD18_08260	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HJD18_08265	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HJD18_08270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HJD18_08275	COG0598	Magnesium transport protein CorA
HJD18_08290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HJD18_08300	COG1597	lipid kinase activity
HJD18_08310	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HJD18_08315	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HJD18_08315	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HJD18_08325	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HJD18_08325	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HJD18_08340	COG0632	four-way junction helicase activity
HJD18_08345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HJD18_08350	COG0217	transcriptional regulatory protein
HJD18_08365	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HJD18_08370	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HJD18_08375	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HJD18_08425	COG0473	3-isopropylmalate dehydrogenase activity
HJD18_08430	COG0471	metal ion transport
HJD18_08455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJD18_08500	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_08505	COG1819	glycosyl
HJD18_08520	COG0358	DNA primase activity
HJD18_08525	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HJD18_08535	COG1381	Involved in DNA repair and RecF pathway recombination
HJD18_08540	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJD18_08550	COG4974	Belongs to the 'phage' integrase family
HJD18_08560	COG2195	Cleaves the N-terminal amino acid of tripeptides
HJD18_08565	COG0504	CTP synthase activity
HJD18_08570	COG0497	DNA recombination
HJD18_08580	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HJD18_08590	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HJD18_08610	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HJD18_08635	COG1556	Lactate utilization protein
HJD18_08645	COG0247	lactate metabolic process
HJD18_08655	COG1960	acyl-CoA dehydrogenase activity
HJD18_08675	COG0006	proline dipeptidase activity
HJD18_08680	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HJD18_08685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HJD18_08690	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HJD18_08755	COG2954	triphosphatase activity
HJD18_08760	COG0318	PFAM AMP-dependent synthetase and ligase
HJD18_08770	COG0753	catalase activity
HJD18_08780	COG1459	type II secretion system
HJD18_08790	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HJD18_08795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HJD18_08800	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HJD18_08805	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HJD18_08810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HJD18_08815	COG0482	sulfurtransferase activity
HJD18_08830	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HJD18_08835	COG0124	histidyl-tRNA synthetase
HJD18_08840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD18_08865	COG2409	Drug exporters of the RND superfamily
HJD18_08875	COG0667	Aldo Keto reductase
HJD18_08905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HJD18_08915	COG1522	sequence-specific DNA binding
HJD18_08920	COG0456	acetyltransferase
HJD18_08980	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HJD18_09020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HJD18_09020	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJD18_09025	COG3852	Histidine kinase
HJD18_09045	COG1132	(ABC) transporter
HJD18_09050	COG0515	serine threonine protein kinase
HJD18_09050	COG2815	serine threonine protein kinase
HJD18_09055	COG4585	Histidine kinase
HJD18_09060	COG2197	response regulator
HJD18_09065	COG3706	GGDEF domain
HJD18_09085	COG0384	phenazine biosynthesis protein PhzF
HJD18_09100	COG1960	acyl-CoA dehydrogenase activity
HJD18_09120	COG3540	Alkaline phosphatase
HJD18_09125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HJD18_09130	COG0477	Major facilitator Superfamily
HJD18_09140	COG2133	pyrroloquinoline quinone binding
HJD18_09160	COG2409	Drug exporters of the RND superfamily
HJD18_09185	COG1120	ATPase activity
HJD18_09190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD18_09195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HJD18_09200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HJD18_09215	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HJD18_09230	COG1181	Belongs to the D-alanine--D-alanine ligase family
HJD18_09245	COG0367	asparagine synthase
HJD18_09260	COG1960	acyl-CoA dehydrogenase activity
HJD18_09265	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HJD18_09275	COG2130	NADP-dependent
HJD18_09280	COG1024	Enoyl-CoA hydratase
HJD18_09285	COG2514	catechol 2,3-dioxygenase activity
HJD18_09295	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJD18_09310	COG0604	alcohol dehydrogenase
HJD18_09310	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_09310	COG3321	synthase
HJD18_09315	COG0745	RESPONSE REGULATOR receiver
HJD18_09320	COG2205	protein histidine kinase activity
HJD18_09330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD18_09330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD18_09335	COG3706	GGDEF domain
HJD18_09355	COG1132	(ABC) transporter
HJD18_09360	COG1132	(ABC) transporter
HJD18_09390	COG0531	amino acid
HJD18_09425	COG2264	protein methyltransferase activity
HJD18_09430	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HJD18_09445	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HJD18_09450	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HJD18_09460	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HJD18_09480	COG0802	atpase or kinase
HJD18_09485	COG1573	uracil-dna glycosylase
HJD18_09495	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HJD18_09500	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HJD18_09505	COG0110	maltose O-acetyltransferase activity
HJD18_09525	COG0583	DNA-binding transcription factor activity
HJD18_09540	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HJD18_09555	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HJD18_09560	COG0556	nucleotide-excision repair
HJD18_09580	COG1196	nuclear chromosome segregation
HJD18_09580	COG0741	lytic transglycosylase activity
HJD18_09580	COG0739	heme binding
HJD18_09585	COG0237	dephospho-CoA kinase activity
HJD18_09600	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_09620	COG1609	Transcriptional regulator
HJD18_09630	COG0022	dehydrogenase e1 component
HJD18_09635	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HJD18_09645	COG0006	proline dipeptidase activity
HJD18_09650	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_09705	COG0683	leucine binding
HJD18_09710	COG1609	Transcriptional regulator
HJD18_09735	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJD18_09735	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HJD18_09765	COG1090	epimerase
HJD18_09790	COG0205	6-phosphofructokinase activity
HJD18_09830	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HJD18_09840	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HJD18_09860	COG0159	tryptophan synthase activity
HJD18_09865	COG0133	tryptophan synthase activity
HJD18_09870	COG0135	phosphoribosylanthranilate isomerase activity
HJD18_09900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HJD18_09905	COG0134	indole-3-glycerol-phosphate synthase activity
HJD18_09910	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HJD18_09915	COG0512	Glutamine amidotransferase of anthranilate synthase
HJD18_09920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HJD18_09925	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HJD18_09925	COG0140	phosphoribosyl-ATP diphosphatase activity
HJD18_09935	COG0492	ferredoxin-NADP+ reductase activity
HJD18_09940	COG1271	oxidase subunit
HJD18_09965	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HJD18_09980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HJD18_09985	COG2264	protein methyltransferase activity
HJD18_09990	COG0484	heat shock protein binding
HJD18_10005	COG2030	dehydratase
HJD18_10010	COG0481	GTPase activity
HJD18_10020	COG0728	peptidoglycan biosynthetic process
HJD18_10025	COG0268	Binds directly to 16S ribosomal RNA
HJD18_10040	COG0658	competence protein
HJD18_10040	COG2333	competence protein COMEC
HJD18_10045	COG1555	photosystem II stabilization
HJD18_10045	COG1596	polysaccharide export
HJD18_10055	COG1254	Belongs to the acylphosphatase family
HJD18_10065	COG0495	leucyl-tRNA aminoacylation
HJD18_10100	COG0799	negative regulation of ribosome biogenesis
HJD18_10105	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HJD18_10110	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HJD18_10115	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HJD18_10120	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HJD18_10125	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HJD18_10130	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HJD18_10140	COG0772	Belongs to the SEDS family
HJD18_10145	COG0768	penicillin binding
HJD18_10165	COG0424	maF-like protein
HJD18_10170	COG0105	UTP biosynthetic process
HJD18_10180	COG0285	dihydrofolate synthase activity
HJD18_10185	COG0525	valine-tRNA ligase activity
HJD18_10235	COG0544	peptidyl-prolyl cis-trans isomerase activity
HJD18_10260	COG1704	LemA family
HJD18_10265	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HJD18_10280	COG3540	Alkaline phosphatase
HJD18_10285	COG2197	response regulator
HJD18_10290	COG4585	Histidine kinase
HJD18_10325	COG3706	GGDEF domain
HJD18_10400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HJD18_10535	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_10560	COG1381	Involved in DNA repair and RecF pathway recombination
HJD18_10570	COG0531	amino acid
HJD18_10620	COG1612	heme a metabolic process
HJD18_10620	COG0109	protoheme IX farnesyltransferase activity
HJD18_10670	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HJD18_10725	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HJD18_10730	COG1024	Enoyl-CoA hydratase
HJD18_10735	COG0537	adenosine 5'-monophosphoramidase activity
HJD18_10740	COG0617	tRNA 3'-terminal CCA addition
HJD18_10745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HJD18_10750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HJD18_10750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HJD18_10755	COG0736	holo-[acyl-carrier-protein] synthase activity
HJD18_10765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HJD18_10770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HJD18_10775	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HJD18_10780	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HJD18_10785	COG1196	nuclear chromosome segregation
HJD18_10785	COG0741	lytic transglycosylase activity
HJD18_10785	COG0739	heme binding
HJD18_10795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HJD18_10795	COG0519	Catalyzes the synthesis of GMP from XMP
HJD18_10800	COG0516	GMP reductase activity
HJD18_10810	COG1686	Belongs to the peptidase S11 family
HJD18_10820	COG0284	orotidine-5'-phosphate decarboxylase activity
HJD18_10830	COG0018	arginyl-trna synthetase
HJD18_10835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD18_10840	COG0501	Belongs to the peptidase M48B family
HJD18_10855	COG0515	serine threonine protein kinase
HJD18_10855	COG2815	serine threonine protein kinase
HJD18_10860	COG0343	queuine tRNA-ribosyltransferase activity
HJD18_10875	COG0149	triose-phosphate isomerase activity
HJD18_10880	COG0126	phosphoglycerate kinase activity
HJD18_10885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HJD18_10905	COG1660	Displays ATPase and GTPase activities
HJD18_10910	COG0322	excinuclease ABC activity
HJD18_10915	COG1024	Enoyl-CoA hydratase
HJD18_10965	COG2154	pterin-4-alpha-carbinolamine dehydratase
HJD18_10975	COG0705	Rhomboid family
HJD18_10975	COG0457	Tetratricopeptide repeat
HJD18_10985	COG1595	DNA-templated transcription, initiation
HJD18_11000	COG1595	DNA-templated transcription, initiation
HJD18_11005	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HJD18_11025	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HJD18_11030	COG0215	cysteine-tRNA ligase activity
HJD18_11035	COG0318	PFAM AMP-dependent synthetase and ligase
HJD18_11045	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HJD18_11050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HJD18_11065	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HJD18_11065	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HJD18_11075	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HJD18_11080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HJD18_11090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HJD18_11095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HJD18_11100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HJD18_11105	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HJD18_11115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HJD18_11125	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HJD18_11130	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HJD18_11135	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HJD18_11140	COG0037	tRNA processing
HJD18_11175	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HJD18_11185	COG2951	lytic endotransglycosylase activity
HJD18_11195	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HJD18_11200	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJD18_11245	COG2252	PERMEase
HJD18_11295	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HJD18_11320	COG1960	acyl-CoA dehydrogenase activity
HJD18_11340	COG1522	sequence-specific DNA binding
HJD18_11360	COG4941	Belongs to the sigma-70 factor family
HJD18_11365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HJD18_11390	COG0003	Pfam Anion-transporting ATPase
HJD18_11400	COG2193	ferroxidase activity
HJD18_11410	COG0628	permease
HJD18_11415	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HJD18_11420	COG0741	lytic transglycosylase activity
HJD18_11420	COG1196	nuclear chromosome segregation
HJD18_11420	COG0739	heme binding
HJD18_11430	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_11460	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HJD18_11495	COG2267	carboxylic ester hydrolase activity
HJD18_11530	COG0596	Alpha beta hydrolase
HJD18_11535	COG2837	iron assimilation
HJD18_11540	COG2822	iron ion transport
HJD18_11575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HJD18_11600	COG2814	Major facilitator Superfamily
HJD18_11605	COG1960	acyl-CoA dehydrogenase activity
HJD18_11615	COG2259	Doxx family
HJD18_11625	COG2200	EAL domain
HJD18_11650	COG1174	glycine betaine transport
HJD18_11665	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HJD18_11690	COG0488	(ABC) transporter
HJD18_11695	COG0584	glycerophosphoryl diester phosphodiesterase
HJD18_11705	COG2391	methyltransferase activity
HJD18_11710	COG0596	Alpha beta hydrolase
HJD18_11720	COG2062	phosphohistidine phosphatase, SixA
HJD18_11725	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_11745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HJD18_11755	COG4608	Belongs to the ABC transporter superfamily
HJD18_11760	COG0444	Belongs to the ABC transporter superfamily
HJD18_11765	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJD18_11770	COG0601	transmembrane transport
HJD18_11780	COG1619	proteins homologs of microcin C7 resistance protein MccF
HJD18_11790	COG3246	L-lysine catabolic process to acetate
HJD18_11845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HJD18_11865	COG4638	Rieske (2fe-2S)
HJD18_11875	COG0647	UMP catabolic process
HJD18_11915	COG0667	Aldo Keto reductase
HJD18_11920	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HJD18_11965	COG0702	epimerase
HJD18_11985	COG2755	lipolytic protein G-D-S-L family
HJD18_11995	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_12010	COG0673	inositol 2-dehydrogenase activity
HJD18_12015	COG0006	proline dipeptidase activity
HJD18_12020	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_12030	COG0179	Fumarylacetoacetate (FAA) hydrolase
HJD18_12035	COG2186	Transcriptional regulator
HJD18_12055	COG0601	transmembrane transport
HJD18_12085	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HJD18_12090	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HJD18_12115	COG0277	FAD linked oxidase domain protein
HJD18_12135	COG3119	arylsulfatase activity
HJD18_12195	COG0477	Major facilitator Superfamily
HJD18_12245	COG1722	exodeoxyribonuclease VII activity
HJD18_12250	COG1570	exodeoxyribonuclease VII activity
HJD18_12260	COG3239	Fatty acid desaturase
HJD18_12315	COG0300	oxidoreductase activity
HJD18_12360	COG0477	Major facilitator Superfamily
HJD18_12480	COG1074	ATP-dependent DNA helicase activity
HJD18_12495	COG1401	restriction endodeoxyribonuclease activity
HJD18_12535	COG0537	adenosine 5'-monophosphoramidase activity
HJD18_12550	COG0406	alpha-ribazole phosphatase activity
HJD18_12555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HJD18_12580	COG2085	NADP oxidoreductase coenzyme F420-dependent
HJD18_12605	COG0463	Glycosyl transferase, family 2
HJD18_12620	COG1764	response to oxidative stress
HJD18_12635	COG1672	PFAM Archaeal ATPase
HJD18_12635	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HJD18_12665	COG1595	DNA-templated transcription, initiation
HJD18_12690	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HJD18_12695	COG1830	Aldolase
HJD18_12700	COG1525	nuclease
HJD18_12710	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HJD18_12740	COG3551	Protein conserved in bacteria
HJD18_12755	COG3119	arylsulfatase activity
HJD18_12760	COG3408	Glycogen debranching enzyme
HJD18_12760	COG3119	arylsulfatase activity
HJD18_12765	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HJD18_12795	COG3551	Protein conserved in bacteria
HJD18_12815	COG0148	phosphopyruvate hydratase activity
HJD18_12820	COG3956	TIGRFAM MazG family protein
HJD18_12825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HJD18_12835	COG1024	Enoyl-CoA hydratase
HJD18_12845	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HJD18_12865	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD18_12865	COG0723	plastoquinol--plastocyanin reductase activity
HJD18_12875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HJD18_12880	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HJD18_12900	COG2508	Transcriptional regulator
HJD18_12910	COG0586	Pfam SNARE associated Golgi protein
HJD18_12915	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HJD18_12920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HJD18_12935	COG0084	hydrolase, TatD family'
HJD18_12945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJD18_12945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJD18_12995	COG1940	carbohydrate kinase activity
HJD18_13000	COG1316	TRANSCRIPTIONal
HJD18_13015	COG0423	glycine-tRNA ligase activity
HJD18_13030	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HJD18_13040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD18_13085	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HJD18_13130	COG0039	L-malate dehydrogenase activity
HJD18_13135	COG0538	isocitrate dehydrogenase activity
HJD18_13145	COG1960	acyl-CoA dehydrogenase activity
HJD18_13150	COG0318	PFAM AMP-dependent synthetase and ligase
HJD18_13155	COG0277	FAD linked oxidase domain protein
HJD18_13155	COG0247	lactate metabolic process
HJD18_13165	COG1994	Peptidase M50
HJD18_13175	COG1053	succinate dehydrogenase
HJD18_13180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HJD18_13205	COG1053	succinate dehydrogenase
HJD18_13210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HJD18_13215	COG2048	Heterodisulfide reductase, subunit B
HJD18_13235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HJD18_13245	COG1472	Belongs to the glycosyl hydrolase 3 family
HJD18_13255	COG2409	Drug exporters of the RND superfamily
HJD18_13265	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HJD18_13270	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HJD18_13290	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HJD18_13295	COG0251	oxidation-reduction process
HJD18_13405	COG0577	efflux transmembrane transporter activity
HJD18_13405	COG1136	(ABC) transporter
HJD18_13410	COG0577	efflux transmembrane transporter activity
HJD18_13410	COG1136	(ABC) transporter
HJD18_13455	COG3321	synthase
HJD18_13455	COG0604	alcohol dehydrogenase
HJD18_13455	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HJD18_13455	COG4221	oxidoreductase activity
HJD18_13460	COG1668	transmembrane transport
HJD18_13465	COG4152	abc transporter atp-binding protein
HJD18_13470	COG1970	mechanosensitive ion channel activity
HJD18_13485	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HJD18_13490	COG3046	protein related to deoxyribodipyrimidine photolyase
HJD18_13495	COG4166	transmembrane transport
HJD18_13500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HJD18_13505	COG0601	transmembrane transport
HJD18_13510	COG0444	Belongs to the ABC transporter superfamily
HJD18_13515	COG4608	Belongs to the ABC transporter superfamily
HJD18_13525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HJD18_13545	COG1230	cation diffusion facilitator family transporter
HJD18_13575	COG0667	Aldo Keto reductase
HJD18_13645	COG0583	DNA-binding transcription factor activity
HJD18_13655	COG3706	GGDEF domain
HJD18_13660	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
HJD18_13680	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HJD18_13690	COG0590	tRNA wobble adenosine to inosine editing
HJD18_13710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HJD18_13725	COG4129	membrane
HJD18_13740	COG0067	glutamate synthase
HJD18_13740	COG0069	glutamate synthase activity
HJD18_13740	COG0070	glutamate synthase
HJD18_13750	COG0367	asparagine synthase
HJD18_13755	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HJD18_13755	COG2308	Evidence 4 Homologs of previously reported genes of
HJD18_13765	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD18_13775	COG0657	acetylesterase activity
HJD18_13790	COG1217	gtp-binding protein TYPA
HJD18_13795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD18_13800	COG0586	Pfam SNARE associated Golgi protein
HJD18_13805	COG1215	transferase activity, transferring glycosyl groups
HJD18_13810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HJD18_13825	COG0726	polysaccharide deacetylase
HJD18_13845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD18_13925	COG3447	MASE1 domain protein
HJD18_13925	COG5002	protein histidine kinase activity
HJD18_13925	COG5001	Diguanylate cyclase
HJD18_13930	COG1846	Transcriptional regulator
HJD18_13940	COG0739	heme binding
HJD18_13940	COG0741	lytic transglycosylase activity
HJD18_13940	COG1196	nuclear chromosome segregation
HJD18_13945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HJD18_13965	COG0646	methionine synthase
HJD18_13965	COG1410	methionine synthase
HJD18_13995	COG0667	Aldo Keto reductase
HJD18_14000	COG1309	transcriptional regulator
HJD18_14015	COG0596	Alpha beta hydrolase
HJD18_14025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HJD18_14040	COG1063	alcohol dehydrogenase
HJD18_14085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HJD18_14095	COG0431	NADPH-dependent FMN reductase
HJD18_14120	COG2815	serine threonine protein kinase
HJD18_14120	COG0515	serine threonine protein kinase
HJD18_14135	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HJD18_14215	COG2080	2 iron, 2 sulfur cluster binding
HJD18_14230	COG0427	acetyl-CoA hydrolase
HJD18_14240	COG1881	PFAM PEBP family protein
HJD18_14245	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_14250	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HJD18_14300	COG1309	transcriptional regulator
HJD18_14305	COG1960	acyl-CoA dehydrogenase activity
HJD18_14330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HJD18_14335	COG0297	glycogen (starch) synthase activity
HJD18_14345	COG0784	Response regulator, receiver
HJD18_14345	COG3437	response regulator, receiver
HJD18_14360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD18_14360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HJD18_14380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD18_14395	COG0515	serine threonine protein kinase
HJD18_14395	COG2815	serine threonine protein kinase
HJD18_14400	COG2423	ornithine cyclodeaminase activity
HJD18_14410	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HJD18_14415	COG0175	sulfate reduction
HJD18_14425	COG0529	Catalyzes the synthesis of activated sulfate
HJD18_14460	COG0730	response to heat
HJD18_14470	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HJD18_14500	COG0372	Belongs to the citrate synthase family
HJD18_14515	COG1960	acyl-CoA dehydrogenase activity
HJD18_14520	COG1960	acyl-CoA dehydrogenase activity
HJD18_14545	COG1609	Transcriptional regulator
HJD18_14595	COG2986	histidine ammonia-lyase
HJD18_14605	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HJD18_14610	COG0242	peptide deformylase activity
HJD18_14620	COG1228	amidohydrolase
HJD18_14625	COG0508	dehydrogenase complex catalyzes the overall conversion of
HJD18_14625	COG0567	Dehydrogenase, E1 component
HJD18_14640	COG0577	efflux transmembrane transporter activity
HJD18_14640	COG1136	(ABC) transporter
HJD18_14650	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HJD18_14675	COG1968	undecaprenyl-diphosphatase activity
HJD18_14690	COG3842	ATPase activity
HJD18_14695	COG1177	transmembrane transport
HJD18_14700	COG1176	ABC-type spermidine putrescine transport system, permease component I
HJD18_14715	COG1309	transcriptional regulator
HJD18_14735	COG1960	acyl-CoA dehydrogenase activity
HJD18_14745	COG0477	Major facilitator Superfamily
HJD18_14760	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HJD18_14765	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HJD18_14775	COG1233	COG1233 Phytoene dehydrogenase and related
HJD18_14800	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_14805	COG0686	Belongs to the AlaDH PNT family
HJD18_14815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HJD18_14820	COG3842	ATPase activity
HJD18_14825	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HJD18_14830	COG1176	ABC-type spermidine putrescine transport system, permease component I
HJD18_14835	COG3833	ABC-type maltose transport systems, permease component
HJD18_14850	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_14860	COG3300	MHYT domain
HJD18_14860	COG5001	Diguanylate cyclase
HJD18_14875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HJD18_14880	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HJD18_14905	COG0248	Ppx GppA phosphatase
HJD18_14910	COG0704	Plays a role in the regulation of phosphate uptake
HJD18_14915	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HJD18_14920	COG0573	inorganic phosphate transmembrane transporter activity
HJD18_14925	COG0573	inorganic phosphate transmembrane transporter activity
HJD18_14930	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HJD18_14945	COG1024	Enoyl-CoA hydratase
HJD18_14950	COG3321	synthase
HJD18_14950	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_14950	COG0604	alcohol dehydrogenase
HJD18_15010	COG0366	Alpha amylase catalytic
HJD18_15020	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HJD18_15050	COG1131	(ABC) transporter
HJD18_15075	COG2030	dehydratase
HJD18_15080	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_15085	COG0183	Belongs to the thiolase family
HJD18_15100	COG0765	amino acid transport
HJD18_15105	COG1126	abc transporter atp-binding protein
HJD18_15110	COG3706	GGDEF domain
HJD18_15115	COG2193	ferroxidase activity
HJD18_15130	COG1063	alcohol dehydrogenase
HJD18_15135	COG0463	Glycosyl transferase, family 2
HJD18_15170	COG0596	Alpha beta hydrolase
HJD18_15175	COG0640	Transcriptional regulator
HJD18_15250	COG0793	Belongs to the peptidase S41A family
HJD18_15250	COG3409	Peptidoglycan-binding domain 1 protein
HJD18_15255	COG2177	Part of the ABC transporter FtsEX involved in
HJD18_15260	COG2884	Cell division ATP-binding protein ftsE
HJD18_15285	COG0785	Cytochrome C biogenesis protein
HJD18_15300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HJD18_15305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJD18_15315	COG3408	Glycogen debranching enzyme
HJD18_15315	COG3119	arylsulfatase activity
HJD18_15345	COG4294	response to UV
HJD18_15355	COG0653	protein targeting
HJD18_15375	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HJD18_15385	COG0460	homoserine dehydrogenase
HJD18_15390	COG0019	diaminopimelate decarboxylase activity
HJD18_15420	COG0183	Belongs to the thiolase family
HJD18_15425	COG1250	3-hydroxyacyl-CoA dehydrogenase
HJD18_15435	COG2267	carboxylic ester hydrolase activity
HJD18_15445	COG2235	arginine
HJD18_15455	COG0655	NAD(P)H dehydrogenase (quinone) activity
HJD18_15470	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HJD18_15510	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HJD18_15565	COG0681	Belongs to the peptidase S26 family
HJD18_15625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HJD18_15680	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HJD18_15680	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HJD18_15690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJD18_15695	COG0785	Cytochrome C biogenesis protein
HJD18_15700	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HJD18_15765	COG1742	UPF0060 membrane protein
HJD18_15810	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HJD18_15815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD18_15850	COG1597	lipid kinase activity
HJD18_15860	COG0012	GTP binding
HJD18_15895	COG2385	sporulation resulting in formation of a cellular spore
HJD18_15910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HJD18_15925	COG0114	fumarate hydratase activity
HJD18_15935	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HJD18_15950	COG1796	DNA polymerase
HJD18_15950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HJD18_15975	COG3481	metal-dependent phosphohydrolase, HD sub domain
HJD18_15995	COG0483	inositol monophosphate 1-phosphatase activity
HJD18_16010	COG2151	metal-sulfur cluster biosynthetic enzyme
HJD18_16010	COG0489	protein tyrosine kinase activity
HJD18_16030	COG0459	protein refolding
HJD18_16035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HJD18_16060	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HJD18_16070	COG1201	RNA secondary structure unwinding
HJD18_16125	COG3481	metal-dependent phosphohydrolase, HD sub domain
HJD18_16130	COG1295	ribonuclease BN
HJD18_16145	COG2376	Dihydroxyacetone kinase
HJD18_16155	COG2066	Belongs to the glutaminase family
HJD18_16170	COG1742	UPF0060 membrane protein
HJD18_16175	COG1247	-acetyltransferase
HJD18_16195	COG0583	DNA-binding transcription factor activity
HJD18_16260	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_16425	COG0492	ferredoxin-NADP+ reductase activity
HJD18_16460	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD18_16480	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_16500	COG1773	rubredoxin
HJD18_16535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HJD18_16545	COG0183	Belongs to the thiolase family
HJD18_16555	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HJD18_16580	COG1960	acyl-CoA dehydrogenase activity
HJD18_16605	COG2124	cytochrome p450
HJD18_16615	COG1960	acyl-CoA dehydrogenase activity
HJD18_16620	COG0183	Belongs to the thiolase family
HJD18_16630	COG1028	Short-chain dehydrogenase reductase Sdr
HJD18_16720	COG0318	PFAM AMP-dependent synthetase and ligase
HJD18_16725	COG2409	Drug exporters of the RND superfamily
HJD18_16755	COG2271	Major facilitator Superfamily
HJD18_16765	COG1819	glycosyl
HJD18_16770	COG1012	belongs to the aldehyde dehydrogenase family
HJD18_16785	COG0010	Belongs to the arginase family
HJD18_16790	COG1111	helicase
HJD18_16790	COG1205	dead DEAH box helicase
HJD18_16805	COG0300	oxidoreductase activity
HJD18_16815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HJD18_16820	COG3119	arylsulfatase activity
HJD18_16825	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HJD18_16830	COG0045	succinate-CoA ligase (ADP-forming) activity
HJD18_16845	COG0698	ribose 5-phosphate isomerase
HJD18_16855	COG2197	response regulator
HJD18_16860	COG4585	Histidine kinase
HJD18_16870	COG1131	(ABC) transporter
HJD18_16875	COG3340	Belongs to the peptidase S51 family
HJD18_16880	COG3340	Belongs to the peptidase S51 family
HJD18_16890	COG0670	Belongs to the BI1 family
HJD18_16905	COG0805	protein transport
HJD18_16910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HJD18_16915	COG0717	Belongs to the dCTP deaminase family
HJD18_16940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HJD18_16955	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HJD18_16960	COG1522	sequence-specific DNA binding
HJD18_16965	COG0113	porphobilinogen synthase activity
HJD18_16990	COG1692	metallophosphoesterase
HJD18_17000	COG0702	epimerase
HJD18_17030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HJD18_17040	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HJD18_17050	COG3191	aminopeptidase activity
HJD18_17060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HJD18_17065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HJD18_17070	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HJD18_17080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HJD18_17090	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HJD18_17115	COG1846	Transcriptional regulator
HJD18_17130	COG0259	pyridoxamine-phosphate oxidase activity
HJD18_17135	COG1475	DNA binding
HJD18_17140	COG1192	Involved in chromosome partitioning
HJD18_17145	COG0357	Ribosomal RNA small subunit methyltransferase G
HJD18_17150	COG1847	R3H domain protein
HJD18_17155	COG0706	membrane insertase activity
HJD18_17160	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HJD18_17165	COG0594	ribonuclease P activity
HJD18_17170	COG0230	Belongs to the bacterial ribosomal protein bL34 family