locus-tag	class	description
HPC62_00105	COG0387	Pfam Sodium calcium exchanger
HPC62_00125	COG2204	response regulator
HPC62_00175	COG1132	(ABC) transporter
HPC62_00250	COG4372	Transposase
HPC62_00255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPC62_00260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPC62_00310	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPC62_00315	COG0848	biopolymer transport protein
HPC62_00320	COG0811	peptide transport
HPC62_00340	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HPC62_00365	COG3655	Transcriptional regulator
HPC62_00390	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPC62_00415	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPC62_00415	COG0574	Belongs to the PEP-utilizing enzyme family
HPC62_00420	COG0440	acetolactate synthase activity
HPC62_00430	COG0148	phosphopyruvate hydratase activity
HPC62_00450	COG2912	Transglutaminase-like superfamily
HPC62_00460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPC62_00465	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPC62_00475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPC62_00490	COG0724	RNA recognition motif
HPC62_00495	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPC62_00505	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPC62_00510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPC62_00515	COG0750	zinc metalloprotease
HPC62_00520	COG0509	glycine decarboxylation via glycine cleavage system
HPC62_00525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPC62_00530	COG0346	lactoylglutathione lyase activity
HPC62_00540	COG0166	Belongs to the GPI family
HPC62_00560	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HPC62_00585	COG0004	ammonium transporteR
HPC62_00590	COG1104	cysteine desulfurase activity
HPC62_00595	COG4249	Peptidase C14 caspase catalytic subunit p20
HPC62_00595	COG2319	Wd-40 repeat
HPC62_00605	COG0515	serine threonine protein kinase
HPC62_00625	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPC62_00630	COG0537	adenosine 5'-monophosphoramidase activity
HPC62_00660	COG1280	lysine exporter protein (LysE YggA)
HPC62_00690	COG0745	RESPONSE REGULATOR receiver
HPC62_00710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HPC62_00720	COG2205	protein histidine kinase activity
HPC62_00720	COG5002	protein histidine kinase activity
HPC62_00720	COG0784	Response regulator, receiver
HPC62_00785	COG0135	phosphoribosylanthranilate isomerase activity
HPC62_00795	COG1994	Peptidase M50
HPC62_00795	COG0517	IMP dehydrogenase activity
HPC62_00805	COG0788	formyltetrahydrofolate deformylase activity
HPC62_00810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPC62_00820	COG0557	exoribonuclease II activity
HPC62_00825	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPC62_00830	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HPC62_00835	COG0303	'Molybdopterin
HPC62_00840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPC62_00850	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HPC62_00865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPC62_00880	COG2723	6-phospho-beta-galactosidase activity
HPC62_00885	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HPC62_00895	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HPC62_00900	COG2094	Belongs to the DNA glycosylase MPG family
HPC62_00945	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HPC62_01010	COG1032	radical SAM domain protein
HPC62_01055	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
HPC62_01075	COG2183	response to ionizing radiation
HPC62_01085	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPC62_01095	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HPC62_01120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPC62_01125	COG0189	ligase activity
HPC62_01140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPC62_01150	COG0402	S-adenosylhomocysteine deaminase activity
HPC62_01165	COG1012	belongs to the aldehyde dehydrogenase family
HPC62_01170	COG0583	DNA-binding transcription factor activity
HPC62_01175	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HPC62_01185	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HPC62_01205	COG0822	iron-sulfur transferase activity
HPC62_01210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPC62_01220	COG2264	protein methyltransferase activity
HPC62_01235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPC62_01240	COG1528	Iron-storage protein
HPC62_01250	COG0318	PFAM AMP-dependent synthetase and ligase
HPC62_01270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPC62_01280	COG0330	HflC and HflK could
HPC62_01310	COG2066	Belongs to the glutaminase family
HPC62_01315	COG0489	protein tyrosine kinase activity
HPC62_01330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HPC62_01345	COG0045	succinate-CoA ligase (ADP-forming) activity
HPC62_01365	COG0151	Belongs to the GarS family
HPC62_01380	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HPC62_01410	COG0402	S-adenosylhomocysteine deaminase activity
HPC62_01420	COG0228	four-way junction DNA binding
HPC62_01430	COG1702	phosphate starvation-inducible protein PhoH
HPC62_01445	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HPC62_01450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPC62_01455	COG4956	integral membrane protein (PIN domain superfamily)
HPC62_01460	COG2226	methyltransferase
HPC62_01465	COG0431	NADPH-dependent FMN reductase
HPC62_01470	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPC62_01480	COG0583	DNA-binding transcription factor activity
HPC62_01485	COG0515	serine threonine protein kinase
HPC62_01495	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPC62_01505	COG0659	secondary active sulfate transmembrane transporter activity
HPC62_01510	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HPC62_01525	COG0534	Mate efflux family protein
HPC62_01550	COG0511	ligase activity, forming carbon-carbon bonds
HPC62_01555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HPC62_01560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPC62_01570	COG0159	tryptophan synthase activity
HPC62_01580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPC62_01590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPC62_01600	COG1196	nuclear chromosome segregation
HPC62_01600	COG0741	lytic transglycosylase activity
HPC62_01600	COG0739	heme binding
HPC62_01605	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPC62_01620	COG4106	trans-aconitate 2-methyltransferase activity
HPC62_01630	COG0156	8-amino-7-oxononanoate synthase activity
HPC62_01640	COG0745	RESPONSE REGULATOR receiver
HPC62_01650	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPC62_01665	COG2367	Beta-lactamase
HPC62_01670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPC62_01675	COG0739	heme binding
HPC62_01710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPC62_01720	COG0140	phosphoribosyl-ATP diphosphatase activity
HPC62_01720	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HPC62_01755	COG1132	(ABC) transporter
HPC62_01780	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPC62_01790	COG5001	Diguanylate cyclase
HPC62_01790	COG3706	GGDEF domain
HPC62_01790	COG4251	negative regulation of phosphorylation
HPC62_01790	COG2203	Gaf domain
HPC62_01795	COG0784	Response regulator, receiver
HPC62_01795	COG2205	protein histidine kinase activity
HPC62_01800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPC62_01805	COG5001	Diguanylate cyclase
HPC62_01805	COG3300	MHYT domain
HPC62_01815	COG0003	Pfam Anion-transporting ATPase
HPC62_01820	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPC62_01825	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPC62_01830	COG2226	methyltransferase
HPC62_01855	COG0592	DNA-directed DNA polymerase activity
HPC62_01865	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPC62_01870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPC62_01885	COG0583	DNA-binding transcription factor activity
HPC62_01900	COG0515	serine threonine protein kinase
HPC62_01925	COG0339	signal peptide processing
HPC62_01945	COG1215	transferase activity, transferring glycosyl groups
HPC62_01950	COG0463	Glycosyl transferase, family 2
HPC62_01960	COG0489	protein tyrosine kinase activity
HPC62_02000	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPC62_02010	COG4242	Belongs to the peptidase S51 family
HPC62_02045	COG2124	cytochrome p450
HPC62_02075	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPC62_02105	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HPC62_02140	COG0189	ligase activity
HPC62_02140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPC62_02150	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPC62_02190	COG2048	Heterodisulfide reductase, subunit B
HPC62_02205	COG1473	amidohydrolase
HPC62_02210	COG1116	anion transmembrane transporter activity
HPC62_02235	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPC62_02240	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPC62_02260	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_02265	COG0811	peptide transport
HPC62_02275	COG0848	biopolymer transport protein
HPC62_02290	COG0384	phenazine biosynthesis protein PhzF
HPC62_02295	COG0586	Pfam SNARE associated Golgi protein
HPC62_02300	COG1073	alpha beta
HPC62_02315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HPC62_02320	COG0667	Aldo Keto reductase
HPC62_02325	COG2884	Cell division ATP-binding protein ftsE
HPC62_02355	COG1028	Short-chain dehydrogenase reductase Sdr
HPC62_02380	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HPC62_02390	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HPC62_02425	COG2885	chlorophyll binding
HPC62_02430	COG2885	chlorophyll binding
HPC62_02435	COG2133	pyrroloquinoline quinone binding
HPC62_02445	COG0174	glutamine synthetase
HPC62_02450	COG5002	protein histidine kinase activity
HPC62_02465	COG4636	protein conserved in cyanobacteria
HPC62_02470	COG0300	oxidoreductase activity
HPC62_02480	COG1074	ATP-dependent DNA helicase activity
HPC62_02525	COG1012	belongs to the aldehyde dehydrogenase family
HPC62_02530	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
HPC62_02545	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HPC62_02565	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPC62_02570	COG1799	cell septum assembly
HPC62_02575	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPC62_02580	COG2234	aminopeptidase activity
HPC62_02585	COG1192	Involved in chromosome partitioning
HPC62_02595	COG5002	protein histidine kinase activity
HPC62_02600	COG0745	RESPONSE REGULATOR receiver
HPC62_02605	COG1192	Involved in chromosome partitioning
HPC62_02610	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HPC62_02625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPC62_02640	COG0492	ferredoxin-NADP+ reductase activity
HPC62_02650	COG0360	Binds together with S18 to 16S ribosomal RNA
HPC62_02655	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPC62_02670	COG1802	Transcriptional regulator
HPC62_02675	COG0525	valine-tRNA ligase activity
HPC62_02685	COG0194	GDP metabolic process
HPC62_02690	COG2052	Domain of unknown function (DUF370)
HPC62_02705	COG3321	synthase
HPC62_02705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPC62_02705	COG0604	alcohol dehydrogenase
HPC62_02705	COG4221	oxidoreductase activity
HPC62_02710	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPC62_02715	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPC62_02725	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPC62_02725	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPC62_02730	COG0454	-acetyltransferase
HPC62_02765	COG0583	DNA-binding transcription factor activity
HPC62_02775	COG0668	transmembrane transport
HPC62_02795	COG2226	methyltransferase
HPC62_02805	COG0720	synthase
HPC62_02810	COG1215	transferase activity, transferring glycosyl groups
HPC62_02820	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HPC62_02825	COG1045	serine acetyltransferase
HPC62_02830	COG0517	IMP dehydrogenase activity
HPC62_02830	COG0516	GMP reductase activity
HPC62_02840	COG0450	alkyl hydroperoxide reductase
HPC62_02845	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
HPC62_02850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPC62_02855	COG3409	Peptidoglycan-binding domain 1 protein
HPC62_02855	COG3429	Glucose-6-phosphate dehydrogenase subunit
HPC62_02910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPC62_02925	COG1429	ligase activity, forming nitrogen-metal bonds
HPC62_02935	COG0459	protein refolding
HPC62_02940	COG0516	GMP reductase activity
HPC62_02965	COG0083	homoserine kinase activity
HPC62_02970	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HPC62_02975	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HPC62_03045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPC62_03050	COG1573	uracil-dna glycosylase
HPC62_03055	COG1252	NADH dehydrogenase
HPC62_03075	COG0071	Belongs to the small heat shock protein (HSP20) family
HPC62_03085	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HPC62_03090	COG3594	Acyltransferase
HPC62_03100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPC62_03115	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPC62_03115	COG0072	phenylalanine-tRNA ligase activity
HPC62_03120	COG0515	serine threonine protein kinase
HPC62_03120	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_03135	COG0515	serine threonine protein kinase
HPC62_03145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPC62_03155	COG2046	Belongs to the sulfate adenylyltransferase family
HPC62_03165	COG1266	CAAX protease self-immunity
HPC62_03175	COG0456	acetyltransferase
HPC62_03185	COG0564	pseudouridine synthase activity
HPC62_03205	COG0237	dephospho-CoA kinase activity
HPC62_03210	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPC62_03215	COG1413	lyase activity
HPC62_03220	COG1413	lyase activity
HPC62_03225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPC62_03230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPC62_03240	COG0237	dephospho-CoA kinase activity
HPC62_03245	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPC62_03250	COG0217	transcriptional regulatory protein
HPC62_03260	COG0784	Response regulator, receiver
HPC62_03265	COG2205	protein histidine kinase activity
HPC62_03265	COG5002	protein histidine kinase activity
HPC62_03265	COG0784	Response regulator, receiver
HPC62_03275	COG5002	protein histidine kinase activity
HPC62_03275	COG0784	Response regulator, receiver
HPC62_03275	COG2205	protein histidine kinase activity
HPC62_03280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPC62_03285	COG0420	3'-5' exonuclease activity
HPC62_03295	COG0424	maF-like protein
HPC62_03300	COG2814	Major facilitator Superfamily
HPC62_03325	COG0701	Predicted permease
HPC62_03365	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPC62_03370	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HPC62_03400	COG0138	bifunctional purine biosynthesis protein purh
HPC62_03410	COG3536	Protein conserved in bacteria
HPC62_03435	COG1480	7TM receptor with intracellular HD hydrolase
HPC62_03455	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HPC62_03465	COG2197	response regulator
HPC62_03470	COG1309	transcriptional regulator
HPC62_03480	COG2169	Transcriptional regulator
HPC62_03480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPC62_03500	COG0765	amino acid transport
HPC62_03505	COG4597	amino acid ABC transporter
HPC62_03510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPC62_03545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPC62_03565	COG0420	3'-5' exonuclease activity
HPC62_03600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPC62_03615	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPC62_03620	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPC62_03635	COG1842	Phage shock protein A
HPC62_03640	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPC62_03645	COG4565	transcriptional regulatory protein
HPC62_03650	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HPC62_03730	COG1366	Belongs to the anti-sigma-factor antagonist family
HPC62_03745	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HPC62_03750	COG0131	Imidazoleglycerol-phosphate dehydratase
HPC62_03755	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPC62_03775	COG0598	Magnesium transport protein CorA
HPC62_03780	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HPC62_03785	COG0601	transmembrane transport
HPC62_03800	COG0745	RESPONSE REGULATOR receiver
HPC62_03810	COG0515	serine threonine protein kinase
HPC62_03810	COG3266	domain, Protein
HPC62_03820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPC62_03825	COG0412	Dienelactone hydrolase
HPC62_03830	COG3384	dioxygenase
HPC62_03860	COG2319	Wd-40 repeat
HPC62_03865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HPC62_03870	COG1381	Involved in DNA repair and RecF pathway recombination
HPC62_03880	COG0438	transferase activity, transferring glycosyl groups
HPC62_03885	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPC62_03890	COG0250	Participates in transcription elongation, termination and antitermination
HPC62_03895	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HPC62_03900	COG0081	regulation of translation
HPC62_03905	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HPC62_03910	COG0222	ribosome binding
HPC62_03915	COG3977	Valine--pyruvate aminotransferase
HPC62_03920	COG0170	dolichyl monophosphate biosynthetic process
HPC62_03930	COG1509	lysine 2,3-aminomutase activity
HPC62_03950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPC62_03955	COG1309	transcriptional regulator
HPC62_03960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPC62_03970	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPC62_03975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HPC62_03980	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HPC62_03990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HPC62_03990	COG0517	IMP dehydrogenase activity
HPC62_03990	COG0617	tRNA 3'-terminal CCA addition
HPC62_04020	COG0137	argininosuccinate synthase activity
HPC62_04035	COG2860	membrane
HPC62_04045	COG0861	Integral membrane protein TerC family
HPC62_04050	COG0826	peptidase U32
HPC62_04060	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HPC62_04065	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HPC62_04080	COG1543	Belongs to the glycosyl hydrolase 57 family
HPC62_04105	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HPC62_04120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPC62_04130	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HPC62_04135	COG0632	four-way junction helicase activity
HPC62_04140	COG0312	modulator of DNA gyrase
HPC62_04150	COG0542	response to heat
HPC62_04160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPC62_04160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HPC62_04210	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPC62_04215	COG1305	Transglutaminase-like
HPC62_04220	COG0768	penicillin binding
HPC62_04225	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPC62_04230	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPC62_04245	COG1222	aaa ATPase
HPC62_04255	COG0346	lactoylglutathione lyase activity
HPC62_04270	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HPC62_04275	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HPC62_04290	COG1733	regulation of RNA biosynthetic process
HPC62_04300	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
HPC62_04305	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HPC62_04305	COG0519	Catalyzes the synthesis of GMP from XMP
HPC62_04310	COG0515	serine threonine protein kinase
HPC62_04320	COG0589	response to stress
HPC62_04325	COG0126	phosphoglycerate kinase activity
HPC62_04330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPC62_04345	COG0758	DNA mediated transformation
HPC62_04345	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPC62_04350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPC62_04380	COG0024	Methionine aminopeptidase
HPC62_04410	COG1691	(AIR) carboxylase
HPC62_04420	COG1620	l-lactate permease
HPC62_04445	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HPC62_04485	COG0297	glycogen (starch) synthase activity
HPC62_04490	COG0500	methyltransferase
HPC62_04500	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HPC62_04515	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HPC62_04560	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPC62_04565	COG0564	pseudouridine synthase activity
HPC62_04580	COG0167	dihydroorotate dehydrogenase activity
HPC62_04595	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPC62_04600	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HPC62_04605	COG0085	RNA polymerase activity
HPC62_04610	COG0084	hydrolase, TatD family'
HPC62_04615	COG0268	Binds directly to 16S ribosomal RNA
HPC62_04620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPC62_04630	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
HPC62_04645	COG1366	Belongs to the anti-sigma-factor antagonist family
HPC62_04650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPC62_04655	COG1530	ribonuclease E activity
HPC62_04660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPC62_04675	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPC62_04680	COG1324	tolerance protein
HPC62_04690	COG0745	RESPONSE REGULATOR receiver
HPC62_04700	COG0569	domain protein
HPC62_04700	COG2985	domain, Protein
HPC62_04715	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPC62_04720	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HPC62_04730	COG2217	Heavy metal translocating P-type atpase
HPC62_04740	COG0456	acetyltransferase
HPC62_04750	COG1063	alcohol dehydrogenase
HPC62_04755	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HPC62_04760	COG0395	ABC-type sugar transport system, permease component
HPC62_04765	COG0667	Aldo Keto reductase
HPC62_04775	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
HPC62_04790	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HPC62_04795	COG0793	Belongs to the peptidase S41A family
HPC62_04800	COG1078	dGTPase activity
HPC62_04805	COG0842	Transport permease protein
HPC62_04810	COG1131	(ABC) transporter
HPC62_04815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPC62_04820	COG0003	Pfam Anion-transporting ATPase
HPC62_04830	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HPC62_04835	COG1490	D-aminoacyl-tRNA deacylase activity
HPC62_04840	COG2205	protein histidine kinase activity
HPC62_04850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPC62_04870	COG0445	tRNA wobble uridine modification
HPC62_04905	COG0751	glycine-tRNA ligase activity
HPC62_04930	COG0587	DNA-directed DNA polymerase activity
HPC62_04940	COG0587	DNA-directed DNA polymerase activity
HPC62_04945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPC62_04960	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPC62_04965	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HPC62_05030	COG1840	ABC-type Fe3 transport system, periplasmic component
HPC62_05035	COG3842	ATPase activity
HPC62_05055	COG0280	phosphate acetyltransferase
HPC62_05055	COG0857	belongs to the CobB CobQ family
HPC62_05060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPC62_05100	COG1121	(ABC) transporter
HPC62_05105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPC62_05115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPC62_05140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HPC62_05150	COG2095	MarC family integral membrane protein
HPC62_05175	COG1002	Type II restriction enzyme, methylase subunits
HPC62_05250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPC62_05260	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPC62_05265	COG1361	Conserved repeat domain
HPC62_05290	COG2082	Precorrin-8x methylmutase
HPC62_05295	COG0772	Belongs to the SEDS family
HPC62_05315	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPC62_05325	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HPC62_05330	COG2211	Major facilitator Superfamily
HPC62_05350	COG0484	heat shock protein binding
HPC62_05355	COG0740	serine-type endopeptidase activity
HPC62_05360	COG0740	serine-type endopeptidase activity
HPC62_05365	COG0740	serine-type endopeptidase activity
HPC62_05370	COG2304	oxidoreductase activity
HPC62_05375	COG1136	(ABC) transporter
HPC62_05385	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPC62_05390	COG2264	protein methyltransferase activity
HPC62_05395	COG1187	pseudouridine synthase activity
HPC62_05405	COG1640	4-alpha-glucanotransferase
HPC62_05420	COG0730	response to heat
HPC62_05425	COG0156	8-amino-7-oxononanoate synthase activity
HPC62_05440	COG0649	NAD binding
HPC62_05450	COG1575	Belongs to the MenA family. Type 1 subfamily
HPC62_05475	COG2003	Belongs to the UPF0758 family
HPC62_05495	COG1166	arginine decarboxylase activity
HPC62_05500	COG0105	UTP biosynthetic process
HPC62_05510	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_05510	COG0515	serine threonine protein kinase
HPC62_05535	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPC62_05540	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HPC62_05550	COG3842	ATPase activity
HPC62_05560	COG0395	ABC-type sugar transport system, permease component
HPC62_05595	COG1126	abc transporter atp-binding protein
HPC62_05600	COG0765	amino acid transport
HPC62_05635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HPC62_05645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPC62_05650	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HPC62_05660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HPC62_05665	COG4208	sulfate ABC transporter
HPC62_05670	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPC62_05675	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPC62_05680	COG0523	cobalamin synthesis protein
HPC62_05685	COG0628	permease
HPC62_05690	COG0527	aspartate kinase activity
HPC62_05695	COG0363	glucosamine-6-phosphate deaminase activity
HPC62_05715	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPC62_05720	COG0552	protein localization to endoplasmic reticulum
HPC62_05735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPC62_05755	COG1077	Cell shape determining protein MreB Mrl
HPC62_05760	COG0629	single-stranded DNA binding
HPC62_05775	COG0768	penicillin binding
HPC62_05780	COG3842	ATPase activity
HPC62_05785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPC62_05790	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPC62_05795	COG1177	transmembrane transport
HPC62_05800	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPC62_05805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPC62_05810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPC62_05835	COG2321	neutral zinc metallopeptidase
HPC62_05850	COG0275	rRNA processing
HPC62_05855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPC62_05865	COG0723	plastoquinol--plastocyanin reductase activity
HPC62_05875	COG0805	protein transport
HPC62_05880	COG0539	negative regulation of cytoplasmic translation
HPC62_05885	COG1716	ATPase activity
HPC62_05910	COG0740	serine-type endopeptidase activity
HPC62_05930	COG1191	sigma factor activity
HPC62_05935	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPC62_05945	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HPC62_05945	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
HPC62_05960	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HPC62_05970	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HPC62_06000	COG0405	Gamma-glutamyltransferase
HPC62_06050	COG4243	Vitamin k epoxide reductase
HPC62_06055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPC62_06080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPC62_06090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HPC62_06095	COG1028	Short-chain dehydrogenase reductase Sdr
HPC62_06100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPC62_06110	COG0628	permease
HPC62_06115	COG0484	heat shock protein binding
HPC62_06125	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPC62_06140	COG0515	serine threonine protein kinase
HPC62_06140	COG3266	domain, Protein
HPC62_06160	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPC62_06160	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPC62_06185	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
HPC62_06205	COG0659	secondary active sulfate transmembrane transporter activity
HPC62_06210	COG0640	Transcriptional regulator
HPC62_06235	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPC62_06265	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
HPC62_06290	COG0792	nuclease activity
HPC62_06320	COG0612	Peptidase, M16
HPC62_06330	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPC62_06350	COG3956	TIGRFAM MazG family protein
HPC62_06360	COG0438	transferase activity, transferring glycosyl groups
HPC62_06365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HPC62_06380	COG0542	response to heat
HPC62_06385	COG0515	serine threonine protein kinase
HPC62_06385	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_06410	COG0288	reversible hydration of carbon dioxide
HPC62_06415	COG4178	(ABC) transporter
HPC62_06420	COG0285	dihydrofolate synthase activity
HPC62_06450	COG0515	serine threonine protein kinase
HPC62_06455	COG1215	transferase activity, transferring glycosyl groups
HPC62_06495	COG0277	FAD linked oxidase domain protein
HPC62_06550	COG1175	transmembrane transport
HPC62_06555	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HPC62_06585	COG0745	RESPONSE REGULATOR receiver
HPC62_06590	COG5002	protein histidine kinase activity
HPC62_06630	COG3385	transposase activity
HPC62_06635	COG0556	nucleotide-excision repair
HPC62_06680	COG3385	transposase activity
HPC62_06725	COG1732	Glycine betaine
HPC62_06750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HPC62_06755	COG0484	heat shock protein binding
HPC62_06780	COG5000	phosphorelay sensor kinase activity
HPC62_06780	COG5002	protein histidine kinase activity
HPC62_06800	COG0335	large ribosomal subunit rRNA binding
HPC62_06820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HPC62_06850	COG0589	response to stress
HPC62_06855	COG0824	Thioesterase
HPC62_06860	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPC62_06865	COG0402	S-adenosylhomocysteine deaminase activity
HPC62_06875	COG2205	protein histidine kinase activity
HPC62_06880	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPC62_06895	COG2233	PERMEase
HPC62_06900	COG3659	wide pore channel activity
HPC62_06925	COG1295	ribonuclease BN
HPC62_06950	COG1136	(ABC) transporter
HPC62_06990	COG0768	penicillin binding
HPC62_07030	COG1472	Belongs to the glycosyl hydrolase 3 family
HPC62_07035	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HPC62_07085	COG0697	spore germination
HPC62_07090	COG3237	CsbD-like
HPC62_07135	COG0107	imidazoleglycerol-phosphate synthase activity
HPC62_07145	COG2363	Small membrane protein
HPC62_07155	COG0215	cysteine-tRNA ligase activity
HPC62_07175	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPC62_07180	COG0587	DNA-directed DNA polymerase activity
HPC62_07190	COG0318	PFAM AMP-dependent synthetase and ligase
HPC62_07195	COG4948	Mandelate Racemase Muconate Lactonizing
HPC62_07200	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPC62_07210	COG0829	nickel cation binding
HPC62_07250	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPC62_07270	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HPC62_07285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPC62_07295	COG2255	four-way junction helicase activity
HPC62_07310	COG0438	transferase activity, transferring glycosyl groups
HPC62_07315	COG0668	transmembrane transport
HPC62_07350	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPC62_07360	COG3654	unkown
HPC62_07365	COG1028	Short-chain dehydrogenase reductase Sdr
HPC62_07375	COG0066	3-isopropylmalate dehydratase activity
HPC62_07385	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HPC62_07400	COG1309	transcriptional regulator
HPC62_07410	COG2385	sporulation resulting in formation of a cellular spore
HPC62_07415	COG3608	succinylglutamate desuccinylase aspartoacylase
HPC62_07430	COG0681	Belongs to the peptidase S26 family
HPC62_07445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPC62_07455	COG0613	PHP domain protein
HPC62_07460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HPC62_07470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HPC62_07475	COG0187	DNA topoisomerase II activity
HPC62_07475	COG1372	Participates in initiation and elongation during chromosome replication
HPC62_07495	COG2144	transferase activity, transferring acyl groups
HPC62_07525	COG2072	flavoprotein involved in K transport
HPC62_07530	COG1012	belongs to the aldehyde dehydrogenase family
HPC62_07545	COG0514	ATP-dependent DNA helicase (RecQ)
HPC62_07550	COG0752	glycyl-tRNA synthetase alpha subunit
HPC62_07555	COG0359	binds to the 23S rRNA
HPC62_07560	COG0305	Participates in initiation and elongation during chromosome replication
HPC62_07560	COG1372	Participates in initiation and elongation during chromosome replication
HPC62_07585	COG0488	(ABC) transporter
HPC62_07590	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HPC62_07610	COG3842	ATPase activity
HPC62_07615	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPC62_07630	COG2010	Cytochrome c
HPC62_07635	COG0745	RESPONSE REGULATOR receiver
HPC62_07645	COG0483	inositol monophosphate 1-phosphatase activity
HPC62_07650	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HPC62_07660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPC62_07670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPC62_07675	COG0134	indole-3-glycerol-phosphate synthase activity
HPC62_07705	COG0746	molybdenum cofactor guanylyltransferase activity
HPC62_07745	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPC62_07750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPC62_07755	COG3937	granule-associated protein
HPC62_07760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPC62_07765	COG0631	protein serine/threonine phosphatase activity
HPC62_07775	COG4251	negative regulation of phosphorylation
HPC62_07800	COG0643	Histidine kinase
HPC62_07800	COG0643	Histidine kinase
HPC62_07800	COG2198	Histidine kinase
HPC62_07800	COG0784	Response regulator, receiver
HPC62_07800	COG2198	Histidine kinase
HPC62_07800	COG0784	Response regulator, receiver
HPC62_07805	COG0840	transmembrane signaling receptor activity
HPC62_07835	COG0129	dihydroxy-acid dehydratase activity
HPC62_07880	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPC62_07885	COG0724	RNA recognition motif
HPC62_07890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HPC62_07895	COG0028	Belongs to the TPP enzyme family
HPC62_07905	COG0561	phosphatase activity
HPC62_07925	COG2081	HI0933 family
HPC62_07935	COG0438	transferase activity, transferring glycosyl groups
HPC62_07955	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPC62_07970	COG0070	glutamate synthase
HPC62_07970	COG0067	glutamate synthase
HPC62_07970	COG0069	glutamate synthase activity
HPC62_07995	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPC62_08015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPC62_08025	COG0372	Belongs to the citrate synthase family
HPC62_08045	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HPC62_08055	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
HPC62_08060	COG0569	domain protein
HPC62_08065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPC62_08070	COG2226	methyltransferase
HPC62_08095	COG0363	glucosamine-6-phosphate deaminase activity
HPC62_08115	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPC62_08120	COG1982	Orn Lys Arg decarboxylase major
HPC62_08125	COG5002	protein histidine kinase activity
HPC62_08135	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPC62_08140	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HPC62_08150	COG0109	protoheme IX farnesyltransferase activity
HPC62_08160	COG1606	tRNA processing
HPC62_08165	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HPC62_08210	COG0193	aminoacyl-tRNA hydrolase activity
HPC62_08215	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPC62_08225	COG0538	isocitrate dehydrogenase activity
HPC62_08240	COG0277	FAD linked oxidase domain protein
HPC62_08250	COG0308	aminopeptidase N
HPC62_08260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HPC62_08265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HPC62_08270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPC62_08275	COG0544	peptidyl-prolyl cis-trans isomerase activity
HPC62_08280	COG0740	serine-type endopeptidase activity
HPC62_08285	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HPC62_08295	COG4279	zinc finger
HPC62_08305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPC62_08335	COG0315	cyclic pyranopterin monophosphate synthase activity
HPC62_08360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPC62_08375	COG2226	methyltransferase
HPC62_08400	COG0709	Synthesizes selenophosphate from selenide and ATP
HPC62_08405	COG0481	GTPase activity
HPC62_08455	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HPC62_08460	COG1494	fructose-1,6-bisphosphatase
HPC62_08465	COG2099	Precorrin-6x reductase
HPC62_08490	COG1940	carbohydrate kinase activity
HPC62_08495	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPC62_08505	COG1132	(ABC) transporter
HPC62_08525	COG2010	Cytochrome c
HPC62_08535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPC62_08535	COG0723	plastoquinol--plastocyanin reductase activity
HPC62_08545	COG0010	Belongs to the arginase family
HPC62_08550	COG0375	protein maturation
HPC62_08580	COG1053	succinate dehydrogenase
HPC62_08585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HPC62_08590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HPC62_08595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPC62_08600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HPC62_08610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HPC62_08615	COG0356	it plays a direct role in the translocation of protons across the membrane
HPC62_08625	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPC62_08630	COG0728	peptidoglycan biosynthetic process
HPC62_08635	COG0110	maltose O-acetyltransferase activity
HPC62_08645	COG0601	transmembrane transport
HPC62_08660	COG0009	L-threonylcarbamoyladenylate synthase
HPC62_08685	COG0784	Response regulator, receiver
HPC62_08685	COG4191	Histidine kinase
HPC62_08715	COG1192	Involved in chromosome partitioning
HPC62_08720	COG0415	Belongs to the DNA photolyase family
HPC62_08735	COG4251	negative regulation of phosphorylation
HPC62_08735	COG3706	GGDEF domain
HPC62_08735	COG5001	Diguanylate cyclase
HPC62_08735	COG2203	Gaf domain
HPC62_08790	COG0415	Belongs to the DNA photolyase family
HPC62_08845	COG0436	Aminotransferase
HPC62_08855	COG0804	urea catabolic process
HPC62_08875	COG5002	protein histidine kinase activity
HPC62_08880	COG4191	Histidine kinase
HPC62_08885	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPC62_08900	COG0058	SHG alpha-glucan phosphorylase activity
HPC62_08905	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HPC62_08910	COG0584	glycerophosphoryl diester phosphodiesterase
HPC62_08950	COG0848	biopolymer transport protein
HPC62_08955	COG0811	peptide transport
HPC62_08965	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HPC62_08975	COG0572	uridine kinase
HPC62_08980	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPC62_08985	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPC62_09005	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPC62_09010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPC62_09015	COG0321	lipoyl(octanoyl) transferase activity
HPC62_09145	COG1595	DNA-templated transcription, initiation
HPC62_09160	COG3903	Transcriptional regulator
HPC62_09160	COG2319	Wd-40 repeat
HPC62_09165	COG1744	ABC transporter substrate-binding protein PnrA-like
HPC62_09195	COG0017	Asparaginyl-tRNA synthetase
HPC62_09255	COG0402	S-adenosylhomocysteine deaminase activity
HPC62_09260	COG2177	Part of the ABC transporter FtsEX involved in
HPC62_09285	COG3706	GGDEF domain
HPC62_09305	COG0316	Belongs to the HesB IscA family
HPC62_09320	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPC62_09335	COG2239	Acts as a magnesium transporter
HPC62_09340	COG1006	Multisubunit Na H antiporter MnhC subunit
HPC62_09345	COG0651	ATP synthesis coupled electron transport
HPC62_09425	COG0154	amidase activity
HPC62_09430	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPC62_09445	COG0659	secondary active sulfate transmembrane transporter activity
HPC62_09450	COG0284	orotidine-5'-phosphate decarboxylase activity
HPC62_09485	COG0412	Dienelactone hydrolase
HPC62_09500	COG2831	hemolysin activation secretion protein
HPC62_09515	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPC62_09530	COG4251	negative regulation of phosphorylation
HPC62_09540	COG1032	radical SAM domain protein
HPC62_09550	COG0124	histidyl-tRNA synthetase
HPC62_09560	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPC62_09580	COG0765	amino acid transport
HPC62_09625	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPC62_09630	COG2197	response regulator
HPC62_09640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPC62_09650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPC62_09655	COG0783	Belongs to the Dps family
HPC62_09740	COG0776	regulation of translation
HPC62_09745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPC62_09750	COG1331	Highly conserved protein containing a thioredoxin domain
HPC62_09775	COG4636	protein conserved in cyanobacteria
HPC62_09780	COG5002	protein histidine kinase activity
HPC62_09785	COG0596	Alpha beta hydrolase
HPC62_09795	COG0018	arginyl-trna synthetase
HPC62_09810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HPC62_09825	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPC62_09830	COG2205	protein histidine kinase activity
HPC62_09830	COG2202	Pas domain
HPC62_09860	COG0347	Belongs to the P(II) protein family
HPC62_09865	COG0095	Lipoate-protein ligase
HPC62_09890	COG3852	Histidine kinase
HPC62_09895	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HPC62_09905	COG0312	modulator of DNA gyrase
HPC62_09920	COG0242	peptide deformylase activity
HPC62_09950	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPC62_10000	COG3119	arylsulfatase activity
HPC62_10030	COG0596	Alpha beta hydrolase
HPC62_10035	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPC62_10055	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPC62_10075	COG0802	atpase or kinase
HPC62_10080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPC62_10115	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPC62_10125	COG0717	Belongs to the dCTP deaminase family
HPC62_10150	COG2226	methyltransferase
HPC62_10160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPC62_10165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPC62_10170	COG1696	Membrane protein involved in D-alanine export
HPC62_10205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPC62_10210	COG0473	3-isopropylmalate dehydrogenase activity
HPC62_10220	COG1131	(ABC) transporter
HPC62_10235	COG0123	including yeast histone deacetylase and acetoin utilization protein
HPC62_10260	COG1994	Peptidase M50
HPC62_10270	COG5002	protein histidine kinase activity
HPC62_10270	COG2205	protein histidine kinase activity
HPC62_10270	COG0784	Response regulator, receiver
HPC62_10275	COG0745	RESPONSE REGULATOR receiver
HPC62_10295	COG0456	acetyltransferase
HPC62_10310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPC62_10315	COG0745	RESPONSE REGULATOR receiver
HPC62_10320	COG0416	fatty acid biosynthetic process
HPC62_10325	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HPC62_10330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPC62_10335	COG0204	Acyl-transferase
HPC62_10335	COG0318	PFAM AMP-dependent synthetase and ligase
HPC62_10350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HPC62_10350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HPC62_10375	COG5001	Diguanylate cyclase
HPC62_10375	COG1716	ATPase activity
HPC62_10390	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HPC62_10395	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HPC62_10400	COG1234	tRNA 3'-trailer cleavage
HPC62_10405	COG0196	riboflavin kinase activity
HPC62_10430	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPC62_10435	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HPC62_10440	COG0019	diaminopimelate decarboxylase activity
HPC62_10445	COG0456	acetyltransferase
HPC62_10450	COG0542	response to heat
HPC62_10455	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HPC62_10460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPC62_10485	COG1214	PFAM Peptidase M22, glycoprotease
HPC62_10540	COG4149	molybdate abc transporter
HPC62_10545	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPC62_10550	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPC62_10560	COG2091	lysine biosynthetic process via aminoadipic acid
HPC62_10565	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HPC62_10570	COG0473	3-isopropylmalate dehydrogenase activity
HPC62_10575	COG1073	alpha beta
HPC62_10595	COG0438	transferase activity, transferring glycosyl groups
HPC62_10595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HPC62_10605	COG0156	8-amino-7-oxononanoate synthase activity
HPC62_10630	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPC62_10635	COG0604	alcohol dehydrogenase
HPC62_10635	COG3321	synthase
HPC62_10665	COG3903	Transcriptional regulator
HPC62_10665	COG3629	intracellular signal transduction
HPC62_10685	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPC62_10690	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPC62_10695	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPC62_10735	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
HPC62_10750	COG0180	Tryptophanyl-tRNA synthetase
HPC62_10765	COG5002	protein histidine kinase activity
HPC62_10770	COG0745	RESPONSE REGULATOR receiver
HPC62_10780	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HPC62_10800	COG0297	glycogen (starch) synthase activity
HPC62_10810	COG0181	hydroxymethylbilane synthase activity
HPC62_10815	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPC62_10820	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPC62_10825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPC62_10855	COG0612	Peptidase, M16
HPC62_10860	COG3001	Fructosamine kinase
HPC62_10870	COG0450	alkyl hydroperoxide reductase
HPC62_10880	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HPC62_10900	COG3932	Exopolysaccharide synthesis, ExoD
HPC62_10905	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HPC62_10915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPC62_10925	COG0432	Pfam Uncharacterised protein family UPF0047
HPC62_10940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPC62_10940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPC62_10945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPC62_10950	COG1408	metallophosphoesterase
HPC62_10955	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPC62_10960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPC62_10965	COG0719	Fe-S assembly protein
HPC62_10970	COG0396	ATPase activity
HPC62_10980	COG0719	Fe-S assembly protein
HPC62_10985	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
HPC62_11025	COG5001	Diguanylate cyclase
HPC62_11030	COG4581	dead DEAH box helicase
HPC62_11035	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPC62_11040	COG0495	leucyl-tRNA aminoacylation
HPC62_11045	COG0798	PFAM Bile acid sodium symporter
HPC62_11055	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPC62_11060	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPC62_11065	COG0640	Transcriptional regulator
HPC62_11070	COG0513	Belongs to the DEAD box helicase family
HPC62_11075	COG4942	peptidase
HPC62_11085	COG1522	sequence-specific DNA binding
HPC62_11090	COG0501	Belongs to the peptidase M48B family
HPC62_11095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPC62_11120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPC62_11130	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPC62_11210	COG3385	transposase activity
HPC62_11220	COG0039	L-malate dehydrogenase activity
HPC62_11250	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HPC62_11255	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPC62_11260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPC62_11310	COG3852	Histidine kinase
HPC62_11330	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_11330	COG0515	serine threonine protein kinase
HPC62_11340	COG0617	tRNA 3'-terminal CCA addition
HPC62_11355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HPC62_11360	COG0686	Belongs to the AlaDH PNT family
HPC62_11370	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPC62_11380	COG5002	protein histidine kinase activity
HPC62_11390	COG3128	pkhd-type hydroxylase
HPC62_11405	COG3385	transposase activity
HPC62_11440	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPC62_11465	COG3385	transposase activity
HPC62_11495	COG0731	radical SAM domain protein
HPC62_11515	COG0789	Transcriptional regulator
HPC62_11520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPC62_11530	COG1271	oxidase subunit
HPC62_11535	COG0730	response to heat
HPC62_11540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPC62_11555	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPC62_11580	COG0500	methyltransferase
HPC62_11590	COG0716	FMN binding
HPC62_11605	COG0316	Belongs to the HesB IscA family
HPC62_11610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPC62_11620	COG5420	small protein containing a coiled-coil domain
HPC62_11630	COG1045	serine acetyltransferase
HPC62_11645	COG1104	cysteine desulfurase activity
HPC62_11655	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
HPC62_11660	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HPC62_11665	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HPC62_11670	COG5554	nitrogen fixation
HPC62_11680	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
HPC62_11695	COG0783	Belongs to the Dps family
HPC62_11700	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPC62_11775	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPC62_11860	COG4251	negative regulation of phosphorylation
HPC62_11870	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
HPC62_11880	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
HPC62_11880	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPC62_11885	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HPC62_11890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_11905	COG1088	dTDP-glucose 4,6-dehydratase activity
HPC62_11945	COG0463	Glycosyl transferase, family 2
HPC62_11965	COG1850	ribulose-bisphosphate carboxylase activity
HPC62_11975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HPC62_11980	COG1131	(ABC) transporter
HPC62_11985	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
HPC62_11995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPC62_11995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPC62_12000	COG2326	polyphosphate kinase activity
HPC62_12005	COG1376	ErfK ybiS ycfS ynhG family protein
HPC62_12010	COG0534	Mate efflux family protein
HPC62_12030	COG0825	malonyl-CoA metabolic process
HPC62_12040	COG1028	Short-chain dehydrogenase reductase Sdr
HPC62_12045	COG0302	gtp cyclohydrolase
HPC62_12070	COG3659	wide pore channel activity
HPC62_12075	COG0463	Glycosyl transferase, family 2
HPC62_12100	COG1672	PFAM Archaeal ATPase
HPC62_12100	COG2319	Wd-40 repeat
HPC62_12145	COG0154	amidase activity
HPC62_12180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HPC62_12195	COG3046	protein related to deoxyribodipyrimidine photolyase
HPC62_12205	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPC62_12210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HPC62_12215	COG0419	ATPase involved in DNA repair
HPC62_12230	COG0850	regulation of cytokinetic process
HPC62_12235	COG2894	cell division
HPC62_12240	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
HPC62_12265	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_12270	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_12275	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_12295	COG0464	growth
HPC62_12305	COG0110	maltose O-acetyltransferase activity
HPC62_12310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPC62_12320	COG0515	serine threonine protein kinase
HPC62_12335	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPC62_12335	COG3409	Peptidoglycan-binding domain 1 protein
HPC62_12340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPC62_12340	COG0426	domain, Protein
HPC62_12355	COG0426	domain, Protein
HPC62_12355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPC62_12365	COG0484	heat shock protein binding
HPC62_12420	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HPC62_12445	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HPC62_12455	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
HPC62_12460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HPC62_12465	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPC62_12470	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPC62_12500	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPC62_12550	COG2188	Transcriptional regulator
HPC62_12555	COG1797	cobyrinic acid a,c-diamide synthase activity
HPC62_12565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPC62_12575	COG1596	polysaccharide export
HPC62_12605	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPC62_12610	COG0025	NhaP-type Na H and K H
HPC62_12615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPC62_12615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HPC62_12620	COG0163	prenyltransferase activity
HPC62_12625	COG3118	belongs to the thioredoxin family
HPC62_12630	COG1842	Phage shock protein A
HPC62_12640	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPC62_12645	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPC62_12655	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HPC62_12660	COG0579	oxidoreductase
HPC62_12665	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPC62_12675	COG0460	homoserine dehydrogenase
HPC62_12685	COG0142	geranyltranstransferase activity
HPC62_12690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HPC62_12695	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HPC62_12715	COG1695	Transcriptional regulator
HPC62_12730	COG1122	ATPase activity
HPC62_12735	COG0357	Ribosomal RNA small subunit methyltransferase G
HPC62_12740	COG2203	Gaf domain
HPC62_12740	COG3706	GGDEF domain
HPC62_12740	COG4251	negative regulation of phosphorylation
HPC62_12740	COG5001	Diguanylate cyclase
HPC62_12745	COG3842	ATPase activity
HPC62_12750	COG5001	Diguanylate cyclase
HPC62_12755	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPC62_12765	COG0745	RESPONSE REGULATOR receiver
HPC62_12770	COG3411	Ferredoxin
HPC62_12775	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
HPC62_12785	COG0343	queuine tRNA-ribosyltransferase activity
HPC62_12790	COG0501	Belongs to the peptidase M48B family
HPC62_12795	COG1196	nuclear chromosome segregation
HPC62_12805	COG2203	Gaf domain
HPC62_12805	COG3706	GGDEF domain
HPC62_12805	COG4251	negative regulation of phosphorylation
HPC62_12805	COG5001	Diguanylate cyclase
HPC62_12810	COG1162	GTPase activity
HPC62_12820	COG0484	heat shock protein binding
HPC62_12830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HPC62_12865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HPC62_12870	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HPC62_12910	COG2261	transglycosylase associated protein
HPC62_12945	COG2211	Major facilitator Superfamily
HPC62_12960	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPC62_12980	COG1968	undecaprenyl-diphosphatase activity
HPC62_13000	COG0489	protein tyrosine kinase activity
HPC62_13000	COG3206	protein involved in exopolysaccharide biosynthesis
HPC62_13030	COG4555	ABC transporter
HPC62_13050	COG0408	coproporphyrinogen oxidase activity
HPC62_13070	COG3206	protein involved in exopolysaccharide biosynthesis
HPC62_13070	COG0489	protein tyrosine kinase activity
HPC62_13075	COG1132	(ABC) transporter
HPC62_13080	COG1216	Glycosyl transferase, family 2
HPC62_13085	COG1216	Glycosyl transferase, family 2
HPC62_13090	COG0438	transferase activity, transferring glycosyl groups
HPC62_13115	COG0505	Belongs to the CarA family
HPC62_13130	COG0459	protein refolding
HPC62_13135	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HPC62_13140	COG1254	Belongs to the acylphosphatase family
HPC62_13145	COG0297	glycogen (starch) synthase activity
HPC62_13150	COG1713	HD superfamily hydrolase involved in NAD metabolism
HPC62_13155	COG0799	negative regulation of ribosome biogenesis
HPC62_13170	COG1007	ATP synthesis coupled electron transport
HPC62_13175	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPC62_13185	COG1132	(ABC) transporter
HPC62_13190	COG1045	serine acetyltransferase
HPC62_13225	COG1596	polysaccharide export
HPC62_13230	COG0489	protein tyrosine kinase activity
HPC62_13235	COG0837	glucose binding
HPC62_13255	COG0714	Associated with various cellular activities
HPC62_13265	COG2234	aminopeptidase activity
HPC62_13270	COG0667	Aldo Keto reductase
HPC62_13280	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPC62_13295	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPC62_13330	COG0438	transferase activity, transferring glycosyl groups
HPC62_13340	COG0438	transferase activity, transferring glycosyl groups
HPC62_13345	COG0438	transferase activity, transferring glycosyl groups
HPC62_13355	COG0438	transferase activity, transferring glycosyl groups
HPC62_13375	COG1132	(ABC) transporter
HPC62_13380	COG0489	protein tyrosine kinase activity
HPC62_13420	COG4172	Belongs to the ABC transporter superfamily
HPC62_13430	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPC62_13435	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPC62_13440	COG0237	dephospho-CoA kinase activity
HPC62_13460	COG0739	heme binding
HPC62_13470	COG2022	thiamine diphosphate biosynthetic process
HPC62_13470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPC62_13490	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPC62_13495	COG0455	bacterial-type flagellum organization
HPC62_13505	COG2205	protein histidine kinase activity
HPC62_13515	COG4251	negative regulation of phosphorylation
HPC62_13520	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
HPC62_13545	COG2198	Histidine kinase
HPC62_13545	COG5002	protein histidine kinase activity
HPC62_13545	COG0784	Response regulator, receiver
HPC62_13560	COG2319	Wd-40 repeat
HPC62_13560	COG1672	PFAM Archaeal ATPase
HPC62_13570	COG0460	homoserine dehydrogenase
HPC62_13585	COG0673	inositol 2-dehydrogenase activity
HPC62_13590	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPC62_13605	COG2267	carboxylic ester hydrolase activity
HPC62_13610	COG1834	amidinotransferase
HPC62_13640	COG2346	COG2346, Truncated hemoglobins
HPC62_13660	COG1489	DNA binding
HPC62_13670	COG0438	transferase activity, transferring glycosyl groups
HPC62_13675	COG0438	transferase activity, transferring glycosyl groups
HPC62_13700	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HPC62_13705	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPC62_13710	COG0529	Catalyzes the synthesis of activated sulfate
HPC62_13765	COG0406	alpha-ribazole phosphatase activity
HPC62_13775	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HPC62_13780	COG0494	nUDIX hydrolase
HPC62_13820	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HPC62_13835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HPC62_13845	COG0640	Transcriptional regulator
HPC62_13855	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPC62_13885	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPC62_13885	COG0022	dehydrogenase e1 component
HPC62_13895	COG5002	protein histidine kinase activity
HPC62_13895	COG3447	MASE1 domain protein
HPC62_13895	COG5001	Diguanylate cyclase
HPC62_13905	COG2319	Wd-40 repeat
HPC62_13905	COG1672	PFAM Archaeal ATPase
HPC62_13950	COG0436	Aminotransferase
HPC62_13990	COG0589	response to stress
HPC62_14005	COG0716	FMN binding
HPC62_14010	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HPC62_14020	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPC62_14020	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPC62_14075	COG1649	PFAM Uncharacterised BCR, COG1649
HPC62_14090	COG0673	inositol 2-dehydrogenase activity
HPC62_14095	COG0745	RESPONSE REGULATOR receiver
HPC62_14110	COG0714	Associated with various cellular activities
HPC62_14130	COG3118	belongs to the thioredoxin family
HPC62_14135	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HPC62_14155	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HPC62_14160	COG2239	Acts as a magnesium transporter
HPC62_14165	COG1234	tRNA 3'-trailer cleavage
HPC62_14170	COG1268	BioY protein
HPC62_14175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPC62_14180	COG1773	rubredoxin
HPC62_14185	COG4447	cellulose binding
HPC62_14230	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPC62_14265	COG5002	protein histidine kinase activity
HPC62_14275	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPC62_14280	COG3659	wide pore channel activity
HPC62_14285	COG0784	Response regulator, receiver
HPC62_14290	COG2205	protein histidine kinase activity
HPC62_14295	COG0590	tRNA wobble adenosine to inosine editing
HPC62_14300	COG0492	ferredoxin-NADP+ reductase activity
HPC62_14335	COG1836	PFAM Integral membrane protein DUF92
HPC62_14340	COG5002	protein histidine kinase activity
HPC62_14365	COG3128	pkhd-type hydroxylase
HPC62_14385	COG2319	Wd-40 repeat
HPC62_14385	COG4249	Peptidase C14 caspase catalytic subunit p20
HPC62_14390	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPC62_14395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPC62_14440	COG1215	transferase activity, transferring glycosyl groups
HPC62_14450	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPC62_14470	COG1215	transferase activity, transferring glycosyl groups
HPC62_14475	COG1895	HEPN domain
HPC62_14480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPC62_14500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPC62_14545	COG0113	porphobilinogen synthase activity
HPC62_14555	COG4221	oxidoreductase activity
HPC62_14560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPC62_14585	COG3848	Pyruvate phosphate dikinase
HPC62_14585	COG0574	Belongs to the PEP-utilizing enzyme family
HPC62_14605	COG4636	protein conserved in cyanobacteria
HPC62_14625	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPC62_14630	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HPC62_14635	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HPC62_14640	COG1846	Transcriptional regulator
HPC62_14665	COG1333	cytochrome c biogenesis protein
HPC62_14670	COG0157	Belongs to the NadC ModD family
HPC62_14710	COG0673	inositol 2-dehydrogenase activity
HPC62_14730	COG1410	methionine synthase
HPC62_14730	COG0646	methionine synthase
HPC62_14745	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPC62_14750	COG0318	PFAM AMP-dependent synthetase and ligase
HPC62_14755	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HPC62_14760	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
HPC62_14760	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPC62_14765	COG3639	organic phosphonate transmembrane transporter activity
HPC62_14770	COG4251	negative regulation of phosphorylation
HPC62_14780	COG1070	Carbohydrate kinase
HPC62_14800	COG4221	oxidoreductase activity
HPC62_14805	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
HPC62_14805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPC62_14820	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPC62_14825	COG0174	glutamine synthetase
HPC62_14830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPC62_14860	COG0629	single-stranded DNA binding
HPC62_14875	COG1361	Conserved repeat domain
HPC62_14875	COG2911	Protein conserved in bacteria
HPC62_14875	COG3266	domain, Protein
HPC62_14885	COG4636	protein conserved in cyanobacteria
HPC62_14895	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HPC62_14900	COG2066	Belongs to the glutaminase family
HPC62_14935	COG2175	clavaminate synthase activity
HPC62_14945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
HPC62_14950	COG0778	Nitroreductase
HPC62_14960	COG0616	signal peptide processing
HPC62_14995	COG2268	Band 7 protein
HPC62_15060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPC62_15080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPC62_15095	COG0488	(ABC) transporter
HPC62_15100	COG0772	Belongs to the SEDS family
HPC62_15120	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPC62_15125	COG1122	ATPase activity
HPC62_15160	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPC62_15165	COG0133	tryptophan synthase activity
HPC62_15175	COG0023	Translation Initiation Factor
HPC62_15185	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HPC62_15195	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HPC62_15200	COG1191	sigma factor activity
HPC62_15215	COG3852	Histidine kinase
HPC62_15280	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HPC62_15330	COG1518	maintenance of DNA repeat elements
HPC62_15330	COG1468	defense response to virus
HPC62_15395	COG5002	protein histidine kinase activity
HPC62_15430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPC62_15460	COG1132	(ABC) transporter
HPC62_15470	COG0515	serine threonine protein kinase
HPC62_15470	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_15510	COG2267	carboxylic ester hydrolase activity
HPC62_15520	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPC62_15535	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPC62_15545	COG0515	serine threonine protein kinase
HPC62_15545	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_15555	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HPC62_15575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HPC62_15605	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPC62_15610	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPC62_15615	COG1845	cytochrome c oxidase, subunit III
HPC62_15630	COG2197	response regulator
HPC62_15635	COG4585	Histidine kinase
HPC62_15640	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HPC62_15660	COG0033	Phosphoglucomutase
HPC62_15665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPC62_15670	COG0588	phosphoglycerate mutase activity
HPC62_15675	COG0469	pyruvate kinase activity
HPC62_15685	COG0824	Thioesterase
HPC62_15690	COG1799	cell septum assembly
HPC62_15705	COG4191	Histidine kinase
HPC62_15720	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPC62_15725	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HPC62_15740	COG0336	Belongs to the RNA methyltransferase TrmD family
HPC62_15745	COG4242	Belongs to the peptidase S51 family
HPC62_15750	COG0189	ligase activity
HPC62_15750	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPC62_15770	COG5002	protein histidine kinase activity
HPC62_15785	COG0300	oxidoreductase activity
HPC62_15785	COG3000	fatty acid hydroxylase
HPC62_15795	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPC62_15800	COG0573	inorganic phosphate transmembrane transporter activity
HPC62_15805	COG0581	inorganic phosphate transmembrane transporter activity
HPC62_15810	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPC62_15835	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPC62_15840	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPC62_15840	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HPC62_15865	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPC62_15885	COG5001	Diguanylate cyclase
HPC62_15890	COG0442	prolyl-tRNA aminoacylation
HPC62_15915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HPC62_15915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HPC62_15920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPC62_15920	COG2205	protein histidine kinase activity
HPC62_15925	COG2197	response regulator
HPC62_15940	COG0475	glutathione-regulated potassium exporter activity
HPC62_15940	COG0589	response to stress
HPC62_15945	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPC62_15950	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HPC62_15960	COG0514	ATP-dependent DNA helicase (RecQ)
HPC62_15975	COG1741	Belongs to the pirin family
HPC62_15985	COG1733	regulation of RNA biosynthetic process
HPC62_16010	COG3629	intracellular signal transduction
HPC62_16010	COG3903	Transcriptional regulator
HPC62_16020	COG4636	protein conserved in cyanobacteria
HPC62_16025	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HPC62_16045	COG1131	(ABC) transporter
HPC62_16050	COG3604	Transcriptional regulator
HPC62_16055	COG0640	Transcriptional regulator
HPC62_16070	COG2226	methyltransferase
HPC62_16090	COG1012	belongs to the aldehyde dehydrogenase family
HPC62_16095	COG0174	glutamine synthetase
HPC62_16100	COG3179	chitinase
HPC62_16110	COG1201	RNA secondary structure unwinding
HPC62_16225	COG1090	epimerase
HPC62_16240	COG1126	abc transporter atp-binding protein
HPC62_16250	COG0612	Peptidase, M16
HPC62_16260	COG2204	response regulator
HPC62_16265	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HPC62_16295	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPC62_16310	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_16310	COG0515	serine threonine protein kinase
HPC62_16315	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HPC62_16330	COG0358	DNA primase activity
HPC62_16355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPC62_16360	COG1230	cation diffusion facilitator family transporter
HPC62_16385	COG1653	transport
HPC62_16410	COG0475	glutathione-regulated potassium exporter activity
HPC62_16435	COG0489	protein tyrosine kinase activity
HPC62_16440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPC62_16485	COG0668	transmembrane transport
HPC62_16530	COG0628	permease
HPC62_16535	COG0398	Pfam SNARE associated Golgi protein
HPC62_16540	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPC62_16545	COG0398	Pfam SNARE associated Golgi protein
HPC62_16585	COG0071	Belongs to the small heat shock protein (HSP20) family
HPC62_16595	COG0149	triose-phosphate isomerase activity
HPC62_16630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPC62_16635	COG0583	DNA-binding transcription factor activity
HPC62_16640	COG0697	spore germination
HPC62_16645	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HPC62_16675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPC62_16740	COG0697	spore germination
HPC62_16750	COG0671	phosphoesterase, PA-phosphatase related
HPC62_16760	COG0745	RESPONSE REGULATOR receiver
HPC62_16790	COG0832	Belongs to the urease beta subunit family
HPC62_16795	COG0831	urea catabolic process
HPC62_16800	COG0037	tRNA processing
HPC62_16810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPC62_16820	COG0312	modulator of DNA gyrase
HPC62_16825	COG2226	methyltransferase
HPC62_16830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPC62_16865	COG3385	transposase activity
HPC62_16880	COG4172	Belongs to the ABC transporter superfamily
HPC62_16885	COG0740	serine-type endopeptidase activity
HPC62_16890	COG5322	oxidoreductase activity
HPC62_16900	COG0006	proline dipeptidase activity
HPC62_16915	COG3854	ATPases associated with a variety of cellular activities
HPC62_16930	COG0457	Tetratricopeptide repeat
HPC62_16935	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HPC62_16940	COG0328	RNA-DNA hybrid ribonuclease activity
HPC62_16945	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPC62_16965	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPC62_16970	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPC62_16980	COG2082	Precorrin-8x methylmutase
HPC62_17050	COG5002	protein histidine kinase activity
HPC62_17055	COG0724	RNA recognition motif
HPC62_17070	COG1215	transferase activity, transferring glycosyl groups
HPC62_17075	COG0784	Response regulator, receiver
HPC62_17090	COG0840	transmembrane signaling receptor activity
HPC62_17090	COG2203	Gaf domain
HPC62_17095	COG2198	Histidine kinase
HPC62_17095	COG0643	Histidine kinase
HPC62_17095	COG0784	Response regulator, receiver
HPC62_17110	COG2738	Putative neutral zinc metallopeptidase
HPC62_17130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HPC62_17135	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HPC62_17150	COG0395	ABC-type sugar transport system, permease component
HPC62_17180	COG0504	CTP synthase activity
HPC62_17205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPC62_17210	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPC62_17215	COG1136	(ABC) transporter
HPC62_17220	COG0577	efflux transmembrane transporter activity
HPC62_17220	COG1136	(ABC) transporter
HPC62_17225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPC62_17235	COG0484	heat shock protein binding
HPC62_17240	COG0154	amidase activity
HPC62_17250	COG3688	RNA-binding protein containing a PIN domain
HPC62_17260	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPC62_17270	COG3118	belongs to the thioredoxin family
HPC62_17275	COG1028	Short-chain dehydrogenase reductase Sdr
HPC62_17280	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HPC62_17285	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HPC62_17320	COG1136	(ABC) transporter
HPC62_17320	COG0577	efflux transmembrane transporter activity
HPC62_17325	COG1252	NADH dehydrogenase
HPC62_17330	COG1011	Hydrolase
HPC62_17345	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HPC62_17355	COG1803	Methylglyoxal synthase
HPC62_17355	COG1597	lipid kinase activity
HPC62_17360	COG0693	protein deglycase activity
HPC62_17375	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPC62_17385	COG0557	exoribonuclease II activity
HPC62_17395	COG0704	Plays a role in the regulation of phosphate uptake
HPC62_17415	COG0784	Response regulator, receiver
HPC62_17415	COG4191	Histidine kinase
HPC62_17430	COG1840	ABC-type Fe3 transport system, periplasmic component
HPC62_17435	COG3128	pkhd-type hydroxylase
HPC62_17440	COG3487	Iron-regulated protein
HPC62_17450	COG2197	response regulator
HPC62_17515	COG0779	Required for maturation of 30S ribosomal subunits
HPC62_17520	COG0195	Participates in both transcription termination and antitermination
HPC62_17525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPC62_17545	COG0419	ATPase involved in DNA repair
HPC62_17550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HPC62_17560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPC62_17580	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HPC62_17595	COG1672	PFAM Archaeal ATPase
HPC62_17595	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
HPC62_17605	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPC62_17620	COG0438	transferase activity, transferring glycosyl groups
HPC62_17625	COG0438	transferase activity, transferring glycosyl groups
HPC62_17650	COG1546	Belongs to the CinA family
HPC62_17650	COG1058	Belongs to the CinA family
HPC62_17655	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPC62_17675	COG2814	Major facilitator Superfamily
HPC62_17710	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HPC62_17715	COG1247	-acetyltransferase
HPC62_17735	COG0297	glycogen (starch) synthase activity
HPC62_17740	COG0501	Belongs to the peptidase M48B family
HPC62_17755	COG2361	Protein of unknown function DUF86
HPC62_17765	COG0556	nucleotide-excision repair
HPC62_17770	COG0463	Glycosyl transferase, family 2
HPC62_17775	COG0628	permease
HPC62_17810	COG0247	lactate metabolic process
HPC62_17815	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPC62_17820	COG1404	Belongs to the peptidase S8 family
HPC62_17820	COG4935	Belongs to the peptidase S8 family
HPC62_17830	COG1132	(ABC) transporter
HPC62_17840	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPC62_17860	COG1160	GTP binding
HPC62_17885	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPC62_17890	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
HPC62_17895	COG0830	nickel cation binding
HPC62_17920	COG0457	Tetratricopeptide repeat
HPC62_17920	COG0463	Glycosyl transferase, family 2
HPC62_17930	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HPC62_17935	COG0594	ribonuclease P activity
HPC62_17945	COG0706	membrane insertase activity
HPC62_17960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPC62_17985	COG1028	Short-chain dehydrogenase reductase Sdr
HPC62_17990	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HPC62_17995	COG1116	anion transmembrane transporter activity
HPC62_18000	COG1032	radical SAM domain protein
HPC62_18030	COG0702	epimerase
HPC62_18045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPC62_18050	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPC62_18055	COG1178	ABC-type Fe3 transport system permease component
HPC62_18060	COG3842	ATPase activity
HPC62_18065	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPC62_18070	COG0010	Belongs to the arginase family
HPC62_18085	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPC62_18105	COG0006	proline dipeptidase activity
HPC62_18130	COG0469	pyruvate kinase activity
HPC62_18135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPC62_18140	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
HPC62_18145	COG2205	protein histidine kinase activity
HPC62_18145	COG3437	response regulator, receiver
HPC62_18145	COG3850	Histidine kinase
HPC62_18145	COG4999	Histidine kinase
HPC62_18150	COG0784	Response regulator, receiver
HPC62_18155	COG4251	negative regulation of phosphorylation
HPC62_18160	COG2197	response regulator
HPC62_18165	COG0412	Dienelactone hydrolase
HPC62_18175	COG1185	polyribonucleotide nucleotidyltransferase activity
HPC62_18190	COG0539	negative regulation of cytoplasmic translation
HPC62_18195	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HPC62_18220	COG0540	Belongs to the ATCase OTCase family
HPC62_18225	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPC62_18230	COG0366	Alpha amylase catalytic
HPC62_18245	COG2816	NAD+ diphosphatase activity
HPC62_18250	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HPC62_18260	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPC62_18275	COG2962	Rard protein
HPC62_18295	COG3706	GGDEF domain
HPC62_18295	COG2203	Gaf domain
HPC62_18295	COG4251	negative regulation of phosphorylation
HPC62_18295	COG5001	Diguanylate cyclase
HPC62_18300	COG0784	Response regulator, receiver
HPC62_18305	COG4251	negative regulation of phosphorylation
HPC62_18310	COG0741	lytic transglycosylase activity
HPC62_18315	COG3852	Histidine kinase
HPC62_18335	COG0454	-acetyltransferase
HPC62_18370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPC62_18380	COG0058	SHG alpha-glucan phosphorylase activity
HPC62_18410	COG0644	oxidoreductase
HPC62_18420	COG1063	alcohol dehydrogenase
HPC62_18425	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HPC62_18440	COG1253	flavin adenine dinucleotide binding
HPC62_18450	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPC62_18455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPC62_18460	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_18470	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
HPC62_18475	COG0069	glutamate synthase activity
HPC62_18475	COG0070	glutamate synthase
HPC62_18475	COG0067	glutamate synthase
HPC62_18480	COG0493	'glutamate synthase
HPC62_18490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HPC62_18495	COG0668	transmembrane transport
HPC62_18515	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPC62_18545	COG2010	Cytochrome c
HPC62_18560	COG0251	oxidation-reduction process
HPC62_18570	COG1194	a g-specific adenine glycosylase
HPC62_18580	COG5002	protein histidine kinase activity
HPC62_18585	COG0438	transferase activity, transferring glycosyl groups
HPC62_18590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPC62_18595	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HPC62_18605	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HPC62_18610	COG2340	Cysteine-rich secretory protein family
HPC62_18630	COG1940	carbohydrate kinase activity
HPC62_18635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPC62_18650	COG1253	flavin adenine dinucleotide binding
HPC62_18655	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPC62_18665	COG0501	Belongs to the peptidase M48B family
HPC62_18685	COG0745	RESPONSE REGULATOR receiver
HPC62_18695	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPC62_18700	COG2351	hydroxyisourate hydrolase activity
HPC62_18705	COG0574	Belongs to the PEP-utilizing enzyme family
HPC62_18705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPC62_18710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPC62_18715	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPC62_18730	COG1012	belongs to the aldehyde dehydrogenase family
HPC62_18730	COG1454	alcohol dehydrogenase
HPC62_18740	COG1733	regulation of RNA biosynthetic process
HPC62_18745	COG0672	)-iron permease
HPC62_18765	COG0436	Aminotransferase
HPC62_18770	COG0371	Dehydrogenase
HPC62_18790	COG2308	Evidence 4 Homologs of previously reported genes of
HPC62_18805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPC62_18810	COG1970	mechanosensitive ion channel activity
HPC62_18815	COG0415	Belongs to the DNA photolyase family
HPC62_18850	COG0783	Belongs to the Dps family
HPC62_18855	COG3781	membrane
HPC62_18860	COG0583	DNA-binding transcription factor activity
HPC62_18880	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPC62_18890	COG1116	anion transmembrane transporter activity
HPC62_18890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPC62_18895	COG1116	anion transmembrane transporter activity
HPC62_18900	COG0243	molybdopterin cofactor binding
HPC62_18925	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HPC62_18930	COG0501	Belongs to the peptidase M48B family
HPC62_18940	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HPC62_18970	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_18975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPC62_18980	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HPC62_18985	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HPC62_18990	COG4451	ribulose bisphosphate carboxylase, small
HPC62_18990	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPC62_19015	COG0631	protein serine/threonine phosphatase activity
HPC62_19020	COG1187	pseudouridine synthase activity
HPC62_19045	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPC62_19055	COG0038	chloride channel
HPC62_19070	COG3385	transposase activity
HPC62_19095	COG0501	Belongs to the peptidase M48B family
HPC62_19100	COG2954	triphosphatase activity
HPC62_19125	COG4948	Mandelate Racemase Muconate Lactonizing
HPC62_19130	COG0482	sulfurtransferase activity
HPC62_19135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HPC62_19140	COG0859	PFAM glycosyl transferase family 9
HPC62_19145	COG0625	glutathione transferase activity
HPC62_19150	COG0789	Transcriptional regulator
HPC62_19215	COG0668	transmembrane transport
HPC62_19235	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPC62_19250	COG0174	glutamine synthetase
HPC62_19275	COG0352	thiamine-phosphate diphosphorylase activity
HPC62_19285	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPC62_19320	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HPC62_19330	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPC62_19375	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HPC62_19395	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPC62_19410	COG0793	Belongs to the peptidase S41A family
HPC62_19415	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HPC62_19430	COG0386	Belongs to the glutathione peroxidase family
HPC62_19435	COG0528	UMP kinase activity
HPC62_19440	COG0233	cytoplasmic translational termination
HPC62_19445	COG0492	ferredoxin-NADP+ reductase activity
HPC62_19450	COG5002	protein histidine kinase activity
HPC62_19455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPC62_19460	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPC62_19470	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPC62_19480	COG1116	anion transmembrane transporter activity
HPC62_19485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPC62_19500	COG1615	UPF0182 protein
HPC62_19515	COG4968	Prepilin-type N-terminal cleavage methylation domain
HPC62_19520	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPC62_19535	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPC62_19545	COG1492	cobalamin metabolic process
HPC62_19575	COG0582	viral genome integration into host DNA
HPC62_19580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HPC62_19590	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HPC62_19620	COG3224	Antibiotic biosynthesis monooxygenase
HPC62_19640	COG1316	TRANSCRIPTIONal
HPC62_19660	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
HPC62_19665	COG0058	SHG alpha-glucan phosphorylase activity
HPC62_19695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPC62_19710	COG1136	(ABC) transporter
HPC62_19710	COG0577	efflux transmembrane transporter activity
HPC62_19715	COG2208	phosphoserine phosphatase activity
HPC62_19730	COG0165	Argininosuccinate lyase
HPC62_19740	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPC62_19745	COG2045	Belongs to the ComB family
HPC62_19750	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPC62_19755	COG0575	Belongs to the CDS family
HPC62_19765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPC62_19770	COG4399	Belongs to the UPF0754 family
HPC62_19780	COG3937	granule-associated protein
HPC62_19800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPC62_19810	COG0625	glutathione transferase activity
HPC62_19820	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HPC62_19840	COG1994	Peptidase M50
HPC62_19840	COG0517	IMP dehydrogenase activity
HPC62_19845	COG0546	phosphoglycolate phosphatase activity
HPC62_19850	COG1793	dna ligase
HPC62_19855	COG3852	Histidine kinase
HPC62_19860	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPC62_19865	COG1028	Short-chain dehydrogenase reductase Sdr
HPC62_19875	COG0051	transcription antitermination factor activity, RNA binding
HPC62_19880	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HPC62_19885	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HPC62_19890	COG0049	tRNA binding
HPC62_19895	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HPC62_19900	COG0316	Belongs to the HesB IscA family
HPC62_19905	COG0662	Cupin 2, conserved barrel domain protein
HPC62_19905	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HPC62_19940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HPC62_19955	COG1192	Involved in chromosome partitioning
HPC62_19980	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HPC62_19985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HPC62_20010	COG0783	Belongs to the Dps family
HPC62_20025	COG1420	regulation of RNA biosynthetic process
HPC62_20035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HPC62_20040	COG1446	asparaginase
HPC62_20065	COG1040	competence protein
HPC62_20070	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HPC62_20075	COG4968	Prepilin-type N-terminal cleavage methylation domain
HPC62_20095	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPC62_20125	COG0259	pyridoxamine-phosphate oxidase activity
HPC62_20135	COG5002	protein histidine kinase activity
HPC62_20140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPC62_20160	COG0542	response to heat
HPC62_20175	COG0745	RESPONSE REGULATOR receiver
HPC62_20180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPC62_20200	COG4251	negative regulation of phosphorylation
HPC62_20200	COG3706	GGDEF domain
HPC62_20200	COG2203	Gaf domain
HPC62_20200	COG5001	Diguanylate cyclase
HPC62_20205	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPC62_20210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPC62_20250	COG0024	Methionine aminopeptidase
HPC62_20295	COG1666	GTP binding
HPC62_20315	COG0438	transferase activity, transferring glycosyl groups
HPC62_20325	COG0583	DNA-binding transcription factor activity
HPC62_20345	COG0489	protein tyrosine kinase activity
HPC62_20375	COG1091	dTDP-4-dehydrorhamnose reductase activity
HPC62_20385	COG1088	dTDP-glucose 4,6-dehydratase activity
HPC62_20405	COG1132	(ABC) transporter
HPC62_20410	COG0668	transmembrane transport
HPC62_20415	COG0653	protein targeting
HPC62_20440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPC62_20460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPC62_20475	COG2205	protein histidine kinase activity
HPC62_20520	COG1899	peptidyl-lysine modification to peptidyl-hypusine
HPC62_20535	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPC62_20540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HPC62_20545	COG0484	heat shock protein binding
HPC62_20560	COG0519	Catalyzes the synthesis of GMP from XMP
HPC62_20580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPC62_20580	COG2022	thiamine diphosphate biosynthetic process
HPC62_20620	COG1216	Glycosyl transferase, family 2
HPC62_20625	COG2814	Major facilitator Superfamily
HPC62_20650	COG1192	Involved in chromosome partitioning
HPC62_20660	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPC62_20690	COG0800	Aldolase
HPC62_20705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPC62_20725	COG0443	Heat shock 70 kDa protein
HPC62_20735	COG1741	Belongs to the pirin family
HPC62_20795	COG5002	protein histidine kinase activity
HPC62_20845	COG0564	pseudouridine synthase activity
HPC62_20850	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPC62_20865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPC62_20875	COG0306	phosphate transporter
HPC62_20890	COG0572	uridine kinase
HPC62_20950	COG0571	ribonuclease III activity
HPC62_20960	COG3437	response regulator, receiver
HPC62_20965	COG3265	gluconokinase activity
HPC62_20975	COG1522	sequence-specific DNA binding
HPC62_20985	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPC62_20990	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HPC62_21000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPC62_21005	COG0025	NhaP-type Na H and K H
HPC62_21015	COG1070	Carbohydrate kinase
HPC62_21025	COG2890	protein-(glutamine-N5) methyltransferase activity
HPC62_21035	COG0009	L-threonylcarbamoyladenylate synthase
HPC62_21045	COG0237	dephospho-CoA kinase activity
HPC62_21045	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HPC62_21060	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HPC62_21060	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HPC62_21070	COG2226	methyltransferase
HPC62_21075	COG0463	Glycosyl transferase, family 2
HPC62_21090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPC62_21095	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
HPC62_21100	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HPC62_21120	COG3437	response regulator, receiver
HPC62_21150	COG1672	PFAM Archaeal ATPase
HPC62_21155	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPC62_21175	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_21180	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPC62_21185	COG4191	Histidine kinase
HPC62_21240	COG1253	flavin adenine dinucleotide binding
HPC62_21245	COG1725	Transcriptional regulator
HPC62_21250	COG2273	Hydrolase Family 16
HPC62_21250	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
HPC62_21265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HPC62_21280	COG3266	domain, Protein
HPC62_21280	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HPC62_21290	COG0497	DNA recombination
HPC62_21305	COG0616	signal peptide processing
HPC62_21310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HPC62_21325	COG1473	amidohydrolase
HPC62_21330	COG0330	HflC and HflK could
HPC62_21335	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HPC62_21340	COG0254	rRNA binding
HPC62_21345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HPC62_21350	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HPC62_21355	COG0101	tRNA pseudouridine synthase activity
HPC62_21360	COG0203	ribosomal protein L17
HPC62_21365	COG0202	RNA polymerase activity
HPC62_21370	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HPC62_21375	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HPC62_21380	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HPC62_21385	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HPC62_21390	COG0563	adenylate kinase activity
HPC62_21395	COG0201	protein transport
HPC62_21400	COG0200	Binds to the 23S rRNA
HPC62_21405	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HPC62_21410	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HPC62_21415	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HPC62_21420	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HPC62_21425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HPC62_21430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HPC62_21435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HPC62_21440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HPC62_21445	COG0255	Belongs to the universal ribosomal protein uL29 family
HPC62_21450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HPC62_21455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HPC62_21460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HPC62_21465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HPC62_21470	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HPC62_21475	COG0089	rRNA binding
HPC62_21480	COG0088	Forms part of the polypeptide exit tunnel
HPC62_21485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HPC62_21495	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HPC62_21505	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HPC62_21510	COG0739	heme binding
HPC62_21555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPC62_21560	COG1121	(ABC) transporter
HPC62_21565	COG0803	Belongs to the bacterial solute-binding protein 9 family
HPC62_21570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HPC62_21590	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
HPC62_21605	COG3659	wide pore channel activity
HPC62_21620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPC62_21625	COG5002	protein histidine kinase activity
HPC62_21630	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HPC62_21635	COG0572	uridine kinase
HPC62_21640	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HPC62_21670	COG5002	protein histidine kinase activity
HPC62_21670	COG3850	Histidine kinase
HPC62_21700	COG0351	phosphomethylpyrimidine kinase
HPC62_21715	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HPC62_21730	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HPC62_21735	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HPC62_21740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPC62_21745	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPC62_21755	COG5002	protein histidine kinase activity
HPC62_21760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPC62_21770	COG2010	Cytochrome c
HPC62_21780	COG0297	glycogen (starch) synthase activity
HPC62_21795	COG0438	transferase activity, transferring glycosyl groups
HPC62_21795	COG0297	glycogen (starch) synthase activity
HPC62_21810	COG0438	transferase activity, transferring glycosyl groups
HPC62_21820	COG0393	Putative heavy-metal-binding
HPC62_21830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_21835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HPC62_21840	COG0484	heat shock protein binding
HPC62_21845	COG0483	inositol monophosphate 1-phosphatase activity
HPC62_21850	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPC62_21860	COG0697	spore germination
HPC62_21870	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPC62_21910	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HPC62_21935	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HPC62_21945	COG1193	negative regulation of DNA recombination
HPC62_21985	COG0586	Pfam SNARE associated Golgi protein
HPC62_22005	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPC62_22005	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HPC62_22055	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPC62_22065	COG5001	Diguanylate cyclase
HPC62_22070	COG0314	molybdopterin synthase activity
HPC62_22075	COG0737	Belongs to the 5'-nucleotidase family
HPC62_22080	COG0793	Belongs to the peptidase S41A family
HPC62_22085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPC62_22090	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPC62_22095	COG0735	belongs to the Fur family
HPC62_22110	COG0762	integral membrane protein
HPC62_22120	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HPC62_22130	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPC62_22160	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPC62_22170	COG0747	negative chemotaxis
HPC62_22180	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPC62_22190	COG2062	phosphohistidine phosphatase, SixA
HPC62_22200	COG1027	Aspartate ammonia-lyase
HPC62_22220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HPC62_22245	COG1022	Amp-dependent synthetase and ligase
HPC62_22255	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPC62_22275	COG1316	TRANSCRIPTIONal
HPC62_22280	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_22300	COG1722	exodeoxyribonuclease VII activity
HPC62_22310	COG1570	exodeoxyribonuclease VII activity
HPC62_22315	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HPC62_22335	COG1959	2 iron, 2 sulfur cluster binding
HPC62_22340	COG2119	membrane
HPC62_22360	COG0515	serine threonine protein kinase
HPC62_22360	COG1357	PFAM Pentapeptide repeats (8 copies)
HPC62_22370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPC62_22375	COG0438	transferase activity, transferring glycosyl groups
HPC62_22405	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPC62_22415	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HPC62_22420	COG0052	Belongs to the universal ribosomal protein uS2 family
HPC62_22425	COG0434	BtpA family
HPC62_22430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HPC62_22435	COG0513	Belongs to the DEAD box helicase family
HPC62_22440	COG4251	negative regulation of phosphorylation
HPC62_22440	COG3706	GGDEF domain
HPC62_22440	COG5001	Diguanylate cyclase
HPC62_22440	COG2203	Gaf domain
HPC62_22450	COG3118	belongs to the thioredoxin family
HPC62_22455	COG0436	Aminotransferase
HPC62_22465	COG0438	transferase activity, transferring glycosyl groups
HPC62_22470	COG1122	ATPase activity
HPC62_22485	COG2154	pterin-4-alpha-carbinolamine dehydratase
HPC62_22490	COG3659	wide pore channel activity
HPC62_22495	COG1959	2 iron, 2 sulfur cluster binding
HPC62_22500	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPC62_22505	COG0484	heat shock protein binding
HPC62_22510	COG1160	GTP binding
HPC62_22515	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HPC62_22520	COG0736	holo-[acyl-carrier-protein] synthase activity
HPC62_22530	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPC62_22535	COG1304	FMN binding
HPC62_22540	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HPC62_22545	COG0857	belongs to the CobB CobQ family
HPC62_22555	COG2252	PERMEase
HPC62_22560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPC62_22565	COG0697	spore germination
HPC62_22600	COG1177	transmembrane transport
HPC62_22615	COG3842	ATPase activity
HPC62_22635	COG0463	Glycosyl transferase, family 2
HPC62_22635	COG1216	Glycosyl transferase, family 2
HPC62_22640	COG1177	transmembrane transport
HPC62_22645	COG3842	ATPase activity
HPC62_22650	COG5002	protein histidine kinase activity
HPC62_22665	COG0438	transferase activity, transferring glycosyl groups
HPC62_22675	COG1215	transferase activity, transferring glycosyl groups
HPC62_22695	COG0561	phosphatase activity
HPC62_22705	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HPC62_22720	COG0012	GTP binding
HPC62_22745	COG1215	transferase activity, transferring glycosyl groups
HPC62_22750	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPC62_22780	COG0322	excinuclease ABC activity
HPC62_22790	COG0515	serine threonine protein kinase
HPC62_22795	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPC62_22800	COG0439	Biotin carboxylase
HPC62_22810	COG5398	heme oxygenase
HPC62_22820	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPC62_22830	COG4935	Belongs to the peptidase S8 family
HPC62_22830	COG1404	Belongs to the peptidase S8 family
HPC62_22840	COG0271	Belongs to the BolA IbaG family
HPC62_22845	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPC62_22865	COG0047	phosphoribosylformylglycinamidine synthase activity
HPC62_22870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPC62_22880	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPC62_22900	COG2217	Heavy metal translocating P-type atpase
HPC62_22905	COG0571	ribonuclease III activity
HPC62_22910	COG1376	ErfK ybiS ycfS ynhG family protein
HPC62_22920	COG0004	ammonium transporteR
HPC62_22935	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPC62_22945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPC62_22960	COG0515	serine threonine protein kinase