locus-tag class description Tcur_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Tcur_0003 ENOG4108J5G 6-phosphogluconate dehydrogenase Tcur_0004 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) Tcur_0005 ENOG4105K7N UPF0232 protein Tcur_0007 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tcur_0025 ENOG4105C7N Xanthine uracil vitamin C permease Tcur_0032 ENOG4105EEM helicase Tcur_0033 ENOG4107S5I aldo keto reductase Tcur_0046 ENOG4105FDP GntR family transcriptional regulator Tcur_0052 ENOG4105E6M Sulphatase-modifying factor protein Tcur_0055 ENOG4105EQK -acetyltransferase Tcur_0059 ENOG4105ZJT Cell division protein CrgA Tcur_0064 ENOG4107TPY serine threonine protein kinase Tcur_0065 ENOG4105CJN penicillin-binding protein Tcur_0068 ENOG4105HZM Fha domain containing protein Tcur_0075 ENOG4107R4I Periplasmic binding protein Tcur_0076 ENOG4105EHG Permease protein Tcur_0077 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Tcur_0084 ENOG4107S91 Sodium hydrogen exchanger Tcur_0089 ENOG4105ETU transcriptional activator (TenA Tcur_0093 ENOG4105WZW rhodanese family Tcur_0096 ENOG4105CEU Arginine dihydrolase Tcur_0098 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Tcur_0110 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_0111 ENOG4105BZU Histidine kinase Tcur_0113 ENOG4105EYF MMPL domain protein Tcur_0119 ENOG4108VJY integral membrane protein Tcur_0121 ENOG4105CQC Prephenate dehydratase Tcur_0123 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) Tcur_0126 ENOG4108K4B hydrolase Tcur_0129 ENOG4108DT4 serine threonine protein kinase Tcur_0130 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor Tcur_0131 ENOG410829K Lysine exporter protein (Lyse ygga) Tcur_0132 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tcur_0137 ENOG4105EUB pirin domain protein Tcur_0142 ENOG4105CS1 NAD(P)H quinone oxidoreductase Tcur_0146 ENOG4105NAF rna polymerase sigma factor Tcur_0150 ENOG4108QER Adenylate cyclase Tcur_0153 ENOG4105BZU Histidine kinase Tcur_0154 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_0160 ENOG4105DEN Luciferase family Tcur_0161 ENOG4107SCK Monooxygenase Tcur_0162 ENOG41068WN Tcur_0172 ENOG4105EYH Exonuclease Tcur_0177 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase Tcur_0186 ENOG4107UBR Extracellular solute-binding protein family 3 Tcur_0190 ENOG4105CIH Imidazole acetol-phosphate transaminase Tcur_0191 ENOG4105D9P serine threonine protein kinase Tcur_0193 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) Tcur_0194 ENOG4105C8V SAICAR synthetase Tcur_0197 ENOG4105C12 Phosphoribosylglycinamide synthetase Tcur_0200 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tcur_0201 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Tcur_0203 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis Tcur_0206 ENOG4107YPT transcriptional regulator Tcur_0207 ENOG4107RCW fructose-bisphosphate aldolase Tcur_0210 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Tcur_0217 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Tcur_0218 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) Tcur_0221 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase Tcur_0228 ENOG4107EXU Short-chain dehydrogenase reductase Sdr Tcur_0234 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tcur_0235 ENOG4105KNI merR family transcriptional Regulator Tcur_0236 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tcur_0237 ENOG4108093 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ Tcur_0238 ENOG4105CFG Acts as a chaperone (By similarity) Tcur_0242 ENOG4105DF6 Fe-S oxidoreductase Tcur_0244 ENOG4105DHP deoxycytidine triphosphate deaminase Tcur_0256 ENOG4105EBR Carboxylesterase Tcur_0259 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) Tcur_0261 ENOG4107DKM chad domain containing protein Tcur_0271 ENOG4105CSU acyl-Coa dehydrogenase Tcur_0277 ENOG4107YPT transcriptional regulator Tcur_0280 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Tcur_0282 ENOG4105CHP RNA polymerase Tcur_0284 ENOG4108QVN serine threonine protein kinase Tcur_0288 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Tcur_0289 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Tcur_0290 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase Tcur_0295 ENOG4108TAC Tcur_0298 ENOG4108UB4 uncharacterized protein ygjQ Tcur_0299 ENOG4105CXB phosphoribosylaminoimidazole synthetase Tcur_0312 ENOG4107QIK phosphoribosylformylglycinamidine synthase Tcur_0314 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Tcur_0316 ENOG410839H phosphoribosylformylglycinamidine synthase Tcur_0318 ENOG4108R85 Short chain dehydrogenase Tcur_0329 ENOG4105CPP Dehydrogenase, E1 component Tcur_0330 ENOG4107RN0 branched-chain alpha-keto acid dehydrogenase subunit E2 Tcur_0333 ENOG4105KAV tspo and mbr like protein Tcur_0334 ENOG4105D22 carbon starvation protein Tcur_0342 ENOG4105E0A ABC, transporter Tcur_0343 ENOG4105EHG Permease protein Tcur_0346 ENOG4105YA8 Transcriptional regulator Tcur_0347 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_0350 ENOG4105C4M (Ubiquinol oxidase) subunit I Tcur_0351 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Tcur_0352 ENOG4108JJ9 ABC, transporter Tcur_0354 ENOG4108JJ8 (ABC) transporter Tcur_0356 ENOG4105DQ5 transport system permease protein Tcur_0357 ENOG4105TVJ transport system, permease Tcur_0358 ENOG4105E0A ABC, transporter Tcur_0363 ENOG4105E8G Major facilitator Superfamily Tcur_0364 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Tcur_0365 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase Tcur_0370 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_0376 ENOG4107QPV Serine Threonine protein kinase Tcur_0382 ENOG4108UGD Serine Threonine protein kinase Tcur_0385 ENOG4105J76 Periplasmic binding protein Tcur_0396 ENOG4107R37 Glutamate dehydrogenase Tcur_0399 ENOG4107Q25 Serine Threonine protein kinase Tcur_0402 ENOG4105EPJ extracellular solute-binding protein family 1 Tcur_0405 ENOG4107TVJ ,Oxidoreductase FAD NAD(P)-binding Tcur_0406 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) Tcur_0407 ENOG4105DS0 Transcriptional regulator, Crp Fnr family Tcur_0413 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Tcur_0419 ENOG4105D9P serine threonine protein kinase Tcur_0437 ENOG4105EDW glycosyl transferase, family 39 Tcur_0438 ENOG4105EDW glycosyl transferase, family 39 Tcur_0443 ENOG4107VRP DNA repair exonuclease Tcur_0447 ENOG4105F38 ABC transporter, permease Tcur_0448 ENOG4105D38 putrescine abc transporter Tcur_0449 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tcur_0450 ENOG4105C7K acetolactate synthase Tcur_0453 ENOG4105C1G acyl-Coa dehydrogenase Tcur_0454 ENOG4105CD5 CoA-binding domain protein Tcur_0455 ENOG4105K6S Short-chain dehydrogenase reductase Sdr Tcur_0461 ENOG4105BZU Histidine kinase Tcur_0464 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Tcur_0465 ENOG4105E2Y ABC, transporter Tcur_0466 ENOG4107UWC ABC, transporter Tcur_0467 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Tcur_0493 ENOG4105K78 MarR family Transcriptional regulator Tcur_0495 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) Tcur_0504 ENOG4107S4F acyltransferase, ws dgat mgat Tcur_0505 ENOG4105CD5 CoA-binding domain protein Tcur_0511 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) Tcur_0520 ENOG4105CY3 ABC transporter, permease Tcur_0521 ENOG4105VEQ Cold shock protein Tcur_0532 ENOG4107HP6 Transcriptional regulator Tcur_0533 ENOG4107HP6 Transcriptional regulator Tcur_0541 ENOG4105C1G acyl-Coa dehydrogenase Tcur_0548 ENOG4105M2Z protein tyrosine serine phosphatase Tcur_0549 ENOG4105C8N cysteinyl-tRNA synthetase Tcur_0551 ENOG4105JAB phenazine biosynthesis protein, phzf family Tcur_0553 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_0554 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Tcur_0559 ENOG4105VCQ rubredoxin Tcur_0560 ENOG4105EEF Alkane 1-monooxygenase Tcur_0565 ENOG4105F95 Monooxygenase Tcur_0567 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Tcur_0575 ENOG4105CYX Short-chain dehydrogenase reductase Sdr Tcur_0577 ENOG4105E39 Enoyl-CoA hydratase Tcur_0578 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tcur_0579 ENOG4105BZU Histidine kinase Tcur_0580 ENOG4105C0H protease Tcur_0582 ENOG4108YZN class I peptide chain release factor Tcur_0583 ENOG4107ZWG Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tcur_0585 ENOG4108Z0R Transferase Tcur_0586 ENOG4106F1P AAA ATPase, central domain protein Tcur_0589 ENOG4105CJ3 phosphate transporter Tcur_0590 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Tcur_0591 ENOG4105E2Z phosphate ABC transporter (Permease Tcur_0594 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) Tcur_0595 ENOG4107NHD transcriptional regulator Tcur_0602 ENOG4105KHC sulfurtransferase Tcur_0603 ENOG4105PKJ carbohydrate binding Tcur_0607 ENOG4105EC2 ftsk spoIIIe Tcur_0624 ENOG4108KGH TRANSCRIPTIONal Tcur_0625 ENOG4108RYC glycosyltransferase Tcur_0627 ENOG4105CBG Sulfatase Tcur_0630 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Tcur_0631 ENOG4108I69 Glycosyl transferases group 1 Tcur_0636 ENOG410602S Transferase Tcur_0638 ENOG4105EY8 ABC transporter Tcur_0642 ENOG4107SJB teichoic acid biosynthesis Tcur_0643 ENOG4105EXC Acyl-transferase Tcur_0649 ENOG4105F1K Glutamine amidotransferase Tcur_0650 ENOG4105DU1 integral membrane protein, terc Tcur_0653 ENOG4108X6U May play a role in the intracellular transport of hydrophobic ligands Tcur_0654 ENOG41090R7 Ferric uptake Tcur_0655 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Tcur_0657 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) Tcur_0662 ENOG4105CGZ zinc metallopeptidase Tcur_0668 ENOG4105EYF MMPL domain protein Tcur_0678 ENOG4108IMY Transcriptional regulator Tcur_0683 ENOG4108XB2 Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity (By similarity) Tcur_0687 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b Tcur_0689 ENOG4108UVJ appr-1-p processing domain protein Tcur_0695 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tcur_0697 ENOG4107RPC Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) Tcur_0699 ENOG4105BZU Histidine kinase Tcur_0704 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) Tcur_0705 ENOG41080XQ Signal transduction protein with cbs domains Tcur_0706 ENOG4105ERH Fumarylacetoacetate hydrolase Tcur_0711 ENOG4105C8N cysteinyl-tRNA synthetase Tcur_0723 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_0724 ENOG4105ERH Fumarylacetoacetate hydrolase Tcur_0725 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase Tcur_0729 ENOG4105C0A alcohol dehydrogenase Tcur_0731 ENOG4105C9U ATP-dependent DNA helicase RecQ Tcur_0732 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) Tcur_0744 ENOG4107SM8 Adenylate Guanylate cyclase Tcur_0745 ENOG4105CPC Aldo Keto reductase Tcur_0748 ENOG4108YYH Nadph-dependent fmn reductase Tcur_0749 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tcur_0752 ENOG4107QIZ NADH dehydrogenase Tcur_0754 ENOG4105C0H protease Tcur_0757 ENOG4105C32 Amino acid ABC transporter (Permease) Tcur_0758 ENOG4105C32 Amino acid ABC transporter (Permease) Tcur_0759 ENOG4105C0Z ABC transporter Tcur_0760 ENOG4108IV0 ABC, transporter Tcur_0761 ENOG4105G9B Transcriptional regulator Tcur_0768 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Tcur_0770 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_0773 ENOG4105E39 Enoyl-CoA hydratase Tcur_0774 ENOG4105C1G acyl-Coa dehydrogenase Tcur_0775 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_0776 ENOG4105H9W Short-chain dehydrogenase reductase Sdr Tcur_0777 ENOG4105NPE arsR family transcriptional regulator Tcur_0780 ENOG4105CFG Acts as a chaperone (By similarity) Tcur_0791 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Tcur_0796 ENOG4105NTW Transcriptional regulator Tcur_0797 ENOG4108SPH protein kinase (EC 2.7.11.1) Tcur_0798 ENOG4105DU6 RNA polymerase Tcur_0799 ENOG4107RDJ Sulfotransferase Tcur_0800 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase Tcur_0804 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tcur_0810 ENOG4105CFI type iii restriction protein res subunit Tcur_0812 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_0815 ENOG4108IG5 Transcriptional regulator Tcur_0818 ENOG4105VEQ Cold shock protein Tcur_0826 ENOG41081HM 2'-5' rna ligase Tcur_0832 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) Tcur_0835 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) Tcur_0838 ENOG4108Q50 Histidine kinase Tcur_0842 ENOG4105F2C Acetyl-CoA acetyltransferase Tcur_0847 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Tcur_0848 ENOG4107SM8 Adenylate Guanylate cyclase Tcur_0851 ENOG4105C26 Dehydrogenase Tcur_0852 ENOG4105C26 Dehydrogenase Tcur_0854 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) Tcur_0858 ENOG4108V1U phospholipid-binding protein Tcur_0863 ENOG4107R1M Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity) Tcur_0867 ENOG4105EMN RNA polymerase sigma factor Tcur_0871 ENOG4107RAN Peptidase, M16 Tcur_0872 ENOG4105WN5 stage II sporulation protein Tcur_0879 ENOG4105KVH Transcriptional regulator Tcur_0880 ENOG4108RYK Nad-dependent epimerase dehydratase Tcur_0884 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) Tcur_0886 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase Tcur_0887 ENOG4108NIW Leucine export protein LeuE Tcur_0892 ENOG4105ECY inositol monophosphatase Tcur_0902 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) Tcur_0904 ENOG4107USC Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity) Tcur_0905 ENOG4105EYF MMPL domain protein Tcur_0910 ENOG41080UU 5-formyltetrahydrofolate cyclo-ligase Tcur_0911 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Tcur_0913 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tcur_0914 ENOG4108RIR Molybdenum cofactor biosynthesis protein Tcur_0924 ENOG4105KZX Pterin carbinolamine dehydratase Tcur_0925 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tcur_0935 ENOG4105DTT CRISPR-associated helicase, cas3 Tcur_0937 ENOG4105DYN CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Tcur_0938 ENOG4105ZHF CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity) Tcur_0939 ENOG4105C0P Mg chelatase subunit ChlI Tcur_0943 ENOG41060M0 Crispr-associated protein, cse4 family Tcur_0946 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Tcur_0948 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) Tcur_0949 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) Tcur_0953 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F Tcur_0954 ENOG4108IG5 Transcriptional regulator Tcur_0956 ENOG4105D2B acyl-CoA dehydrogenase Tcur_0959 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_0960 ENOG4105D2B acyl-CoA dehydrogenase Tcur_0961 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Tcur_0965 ENOG4105CVJ phosphoglycerate mutase Tcur_0968 ENOG4105D0M Protease HtpX homolog Tcur_0970 ENOG4105D7N magnesium and cobalt transport protein CorA Tcur_0976 ENOG4105C3Q Glycosyl transferase, family 2 Tcur_0979 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) Tcur_0980 ENOG4105F8V Hydrolase, tatD family Tcur_0984 ENOG4105NAF rna polymerase sigma factor Tcur_0985 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) Tcur_0987 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) Tcur_0990 ENOG4105C5H ABC transporter Tcur_0992 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) Tcur_0994 ENOG4108RZE Tetr family transcriptional regulator Tcur_0997 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Tcur_0998 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Tcur_0999 ENOG4107XT7 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) Tcur_1000 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Tcur_1001 ENOG4105D3Q Sugar transferase Tcur_1002 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo Tcur_1003 ENOG4105C11 sulfate adenylyltransferase), subunit 2 Tcur_1015 ENOG4107G87 m6 family metalloprotease domain protein Tcur_1020 ENOG4107TSN permease Tcur_1021 ENOG4107T1U Catalyzes the synthesis of activated sulfate (By similarity) Tcur_1026 ENOG4105BZ4 penicillin-binding protein Tcur_1029 ENOG4105D5P Methylmalonyl-coA mutase Tcur_1033 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Tcur_1036 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) Tcur_1040 ENOG4105E50 uracil-dna glycosylase Tcur_1041 ENOG4105CEP NADH dehydrogenase Tcur_1042 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Tcur_1045 ENOG4105CHU acetyl-coa acetyltransferase Tcur_1049 ENOG4105EYF MMPL domain protein Tcur_1053 ENOG4107KWJ von Willebrand factor, type A Tcur_1054 ENOG4105EET magnesium chelatase Tcur_1057 ENOG4105C7B Threonine dehydratase Tcur_1061 ENOG4105VQU rdd domain containing protein Tcur_1062 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase Tcur_1064 ENOG4107YD5 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) Tcur_1066 ENOG4105T1M mycothiol conjugate amidase mca Tcur_1070 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) Tcur_1071 ENOG4105C7Z Conserved Protein Tcur_1075 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Tcur_1076 ENOG4108IAB Phoh family Tcur_1078 ENOG4105C9Q fumarate hydratase class II Tcur_1079 ENOG4105D9P serine threonine protein kinase Tcur_1080 ENOG4107GFK fumarate Tcur_1088 ENOG4105YX8 Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tcur_1089 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) Tcur_1091 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) Tcur_1095 ENOG4105C3G gtp-binding protein Tcur_1107 ENOG4105CI3 gtp-binding protein typa Tcur_1111 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tcur_1113 ENOG4105D9P serine threonine protein kinase Tcur_1116 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) Tcur_1118 ENOG4105IJJ transcriptional regulator, crp fnr family Tcur_1125 ENOG4105BZU Histidine kinase Tcur_1127 ENOG4105BZ1 (ABC) transporter Tcur_1131 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) Tcur_1135 ENOG4105C8Y Acetylornithine aminotransferase Tcur_1137 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) Tcur_1143 ENOG4105C8N cysteinyl-tRNA synthetase Tcur_1144 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Tcur_1146 ENOG4108UKI Enoyl-CoA hydratase Tcur_1147 ENOG4108ZJ4 polysaccharide deacetylase Tcur_1149 ENOG4108Z4U Ferredoxin Tcur_1156 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) Tcur_1157 ENOG4108Z4X TRANSCRIPTIONal Tcur_1158 ENOG4105C1G acyl-Coa dehydrogenase Tcur_1167 ENOG4105TV1 Transcriptional regulator Tcur_1171 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) Tcur_1172 ENOG4107R4C succinyl-diaminopimelate desuccinylase Tcur_1173 ENOG4108URH decarboxylase Tcur_1174 ENOG4108URH decarboxylase Tcur_1175 ENOG4105EEI dihydropteroate synthase Tcur_1178 ENOG4108R3E Dna-3-methyladenine glycosylase i Tcur_1180 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Tcur_1183 ENOG4105DU6 RNA polymerase Tcur_1186 ENOG4105C0H protease Tcur_1187 ENOG410630M Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) Tcur_1190 ENOG4105CJW magnesium transporter Tcur_1192 ENOG4105CI0 Citrate lyase Tcur_1199 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) Tcur_1200 ENOG4105C1J atp-dependent rna helicase Tcur_1202 ENOG4108UGD Serine Threonine protein kinase Tcur_1206 ENOG4107QN2 dihydrolipoyl dehydrogenase Tcur_1207 ENOG4105DQE DNA ligase Tcur_1209 ENOG4105FDF Could be involved in DNA repair (By similarity) Tcur_1211 ENOG4105CG5 Glycosyl transferase (Group 1 Tcur_1212 ENOG4107SJB teichoic acid biosynthesis Tcur_1214 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Tcur_1215 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Tcur_1219 ENOG4105MGM doxx family Tcur_1220 ENOG4105DB7 PHP domain protein Tcur_1222 ENOG4107TXC Transcriptional regulator Tcur_1223 ENOG4105CHR reductase Tcur_1225 ENOG4107U9T Pfam:Ribonuclease_BN Tcur_1227 ENOG4105CSU acyl-Coa dehydrogenase Tcur_1228 ENOG4108VUG Enoyl-CoA hydratase Tcur_1234 ENOG4105K70 DNA-binding protein Tcur_1235 ENOG4105CGH 5'-nucleotidase Tcur_1236 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Tcur_1238 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_1241 ENOG4105CYC Transferase Tcur_1248 ENOG4105D9P serine threonine protein kinase Tcur_1253 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_1254 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) Tcur_1257 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tcur_1263 ENOG4105FCS tRNA rRNA methyltransferase Tcur_1268 ENOG4105BZ4 penicillin-binding protein Tcur_1271 ENOG4107QRI Phosphoketolase Tcur_1272 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) Tcur_1288 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Tcur_1291 ENOG4105CTK cobaltochelatase, cobn subunit Tcur_1300 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_1301 ENOG4105BZU Histidine kinase Tcur_1303 ENOG4105DYW oxidoreductase Tcur_1310 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Tcur_1311 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) Tcur_1314 ENOG4105CIA precorrin-4 C(11)-methyltransferase Tcur_1315 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) Tcur_1317 ENOG4105E4R Precorrin-3B C17-methyltransferase Tcur_1319 ENOG41081F0 Precorrin-8x methylmutase Tcur_1320 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein Tcur_1322 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Tcur_1323 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Tcur_1327 ENOG4107YH6 single-stranded DNA-binding protein Tcur_1328 ENOG4105BZU Histidine kinase Tcur_1331 ENOG4105E5T Major Facilitator Superfamily Tcur_1334 ENOG4105D8X mechanosensitive ion channel Tcur_1338 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tcur_1344 ENOG4105C01 Dihydroxy-acid dehydratase Tcur_1350 ENOG4105MC2 DSBA oxidoreductase Tcur_1354 ENOG4108JJB ABC transporter Tcur_1359 ENOG41062D9 Histidine kinase Tcur_1367 ENOG4105C2C drug resistance transporter, Bcr CflA Tcur_1374 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Tcur_1375 ENOG4105E2Y ABC, transporter Tcur_1378 ENOG4105CPU Monooxygenase Tcur_1385 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Tcur_1387 ENOG4108IYU L-aspartate oxidase Tcur_1395 ENOG4105CFG Acts as a chaperone (By similarity) Tcur_1397 ENOG4105GSW Tcur_1403 ENOG4105CFG Acts as a chaperone (By similarity) Tcur_1406 ENOG4105C4R Atp-dependent dna helicase Tcur_1407 ENOG4105D9P serine threonine protein kinase Tcur_1422 ENOG4107TV1 YD repeat protein Tcur_1433 ENOG4106A3M Cytochrome p-450 Tcur_1453 ENOG4108IJ6 ABC transporter Tcur_1454 ENOG4105I5W Transporter Tcur_1455 ENOG4105DG7 nitrate ABC transporter Tcur_1456 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Tcur_1457 ENOG4105DWV Homoserine O-trans-acetylase Tcur_1460 ENOG4105EB3 Histidine kinase Tcur_1461 ENOG4108PYU two-component system response regulator Tcur_1472 ENOG4105CHU acetyl-coa acetyltransferase Tcur_1473 ENOG4105CHR reductase Tcur_1475 ENOG4105D2B acyl-CoA dehydrogenase Tcur_1476 ENOG4105D2B acyl-CoA dehydrogenase Tcur_1485 ENOG4105VJY transcriptional regulator Tcur_1486 ENOG41061H0 Monooxygenase Tcur_1488 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_1494 ENOG4107QRT dEAD DEAH box helicase Tcur_1498 ENOG4108M24 von Willebrand factor, type A Tcur_1504 ENOG4105VT3 DNA binding domain protein, excisionase family Tcur_1524 ENOG4105E7Q Cob(II)yrinic acid a,c-diamide reductase Tcur_1528 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Tcur_1529 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tcur_1530 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) Tcur_1531 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) Tcur_1532 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_1535 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Tcur_1536 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Tcur_1538 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) Tcur_1539 ENOG4105DFF Rod shape-determining protein mreb Tcur_1542 ENOG4105CJN penicillin-binding protein Tcur_1543 ENOG4105CNI cell division protein FtsW Tcur_1546 ENOG4105C03 ribonuclease Tcur_1547 ENOG410826X This protein binds to 23S rRNA in the presence of protein L20 (By similarity) Tcur_1548 ENOG4105K46 50S ribosomal protein l27 Tcur_1549 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control Tcur_1551 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) Tcur_1552 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) Tcur_1553 ENOG4105D0M Protease HtpX homolog Tcur_1554 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Tcur_1555 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) Tcur_1556 ENOG4105CVJ phosphoglycerate mutase Tcur_1560 ENOG4105EWC Purine nucleoside phosphorylase Tcur_1561 ENOG4105BZ9 Cytochrome C oxidase, subunit I Tcur_1564 ENOG4108RF4 Tetr family transcriptional regulator Tcur_1574 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase Tcur_1576 ENOG4108MMM RNA Polymerase Tcur_1578 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Tcur_1579 ENOG4105D74 hydrolase Tcur_1581 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_1582 ENOG4105C8T Leucyl-tRNA synthetase Tcur_1583 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) Tcur_1585 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) Tcur_1586 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Tcur_1587 ENOG4105CV8 reductase Tcur_1591 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tcur_1592 ENOG4106F1P AAA ATPase, central domain protein Tcur_1607 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tcur_1609 ENOG4107XFJ UPF0246 protein Tcur_1612 ENOG4107R7I amino acid Tcur_1618 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Tcur_1619 ENOG4105DMF Dehydrogenase Tcur_1620 ENOG4105CJ1 ABC, transporter Tcur_1621 ENOG4105DUM transcriptional regulator, lysR family Tcur_1622 ENOG4105C7B Threonine dehydratase Tcur_1623 ENOG4108ZGX Histidine kinase Tcur_1624 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_1626 ENOG4105C9U ATP-dependent DNA helicase RecQ Tcur_1628 ENOG4105CD5 CoA-binding domain protein Tcur_1639 ENOG41082KT Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) Tcur_1640 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tcur_1643 ENOG4105D74 hydrolase Tcur_1644 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Tcur_1646 ENOG4107ZED Uncharacterised protein family UPF0047 Tcur_1650 ENOG4105DBI uridine monophosphokinase Tcur_1651 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_1652 ENOG4105BZU Histidine kinase Tcur_1653 ENOG4105EG6 Saccharopine dehydrogenase Tcur_1654 ENOG4105DDW LysR family Transcriptional regulator Tcur_1655 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate Tcur_1656 ENOG4108VFZ ribulose bisphosphate carboxylase, small Tcur_1657 ENOG4106F1P AAA ATPase, central domain protein Tcur_1659 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tcur_1664 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A Tcur_1666 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Tcur_1671 ENOG4108JEB The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Tcur_1673 ENOG4105CVJ phosphoglycerate mutase Tcur_1675 ENOG4105EGD dinuclear metal center protein, YbgI family Tcur_1679 ENOG4105CHH sulfate transporter Tcur_1681 ENOG4108V1U phospholipid-binding protein Tcur_1685 ENOG410905X membrane-flanked domain protein Tcur_1690 ENOG4105FAA peptidase M23 Tcur_1691 ENOG4107QME Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) Tcur_1694 ENOG4105F44 Two component transcriptional regulator, winged helix family Tcur_1695 ENOG4106F60 Histidine kinase Tcur_1701 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) Tcur_1703 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Tcur_1705 ENOG4107ZFB This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) Tcur_1710 ENOG4105CZN Potassium uptake protein Tcur_1713 ENOG4107VEG TrkA-N domain protein Tcur_1714 ENOG4105C0X amino acid Tcur_1715 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) Tcur_1723 ENOG4107S1Q Phosphatase Tcur_1727 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_1728 ENOG4105N14 lysine exporter protein LysE YggA Tcur_1732 ENOG4105ETE Transcriptional regulator (LacI family Tcur_1734 ENOG4105DRS transport system, permease Tcur_1738 ENOG4108W9Q Endoglucanase (EC 3.2.1.4) Tcur_1739 ENOG4105CG3 alpha amylase, catalytic region Tcur_1742 ENOG4105C01 Dihydroxy-acid dehydratase Tcur_1743 ENOG4105CHC glucokinase (EC 2.7.1.2) Tcur_1744 ENOG4108UHU Aldolase Tcur_1746 ENOG4108762 serine threonine protein kinase Tcur_1749 ENOG4107QM5 aconitate hydratase Tcur_1752 ENOG4108VCA G U mismatch-specific DNA glycosylase Tcur_1754 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) Tcur_1755 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) Tcur_1757 ENOG4105EQH reductase Tcur_1758 ENOG4105CUB amino acid Tcur_1759 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Tcur_1760 ENOG4105CHU acetyl-coa acetyltransferase Tcur_1763 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) Tcur_1765 ENOG4105C1Q protoporphyrinogen oxidase Tcur_1766 ENOG4107JTW chlorite dismutase Tcur_1768 ENOG4105E0X reductase Tcur_1769 ENOG4105DGI Alkaline phosphatase Tcur_1771 ENOG4105WCJ ec 1.1.1.193 Tcur_1772 ENOG4105NAF rna polymerase sigma factor Tcur_1778 ENOG4108IG5 Transcriptional regulator Tcur_1782 ENOG4105CSU acyl-Coa dehydrogenase Tcur_1786 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) Tcur_1788 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) Tcur_1802 ENOG4105D7T ABC transporter Tcur_1803 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) Tcur_1807 ENOG4105BZ1 (ABC) transporter Tcur_1808 ENOG4108KGH TRANSCRIPTIONal Tcur_1812 ENOG4108V06 Glutathione peroxidase Tcur_1818 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Tcur_1826 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tcur_1832 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Tcur_1834 ENOG4105F95 Monooxygenase Tcur_1835 ENOG4107TE5 Lipid kinase Tcur_1837 ENOG4105PGM cation diffusion facilitator family transporter Tcur_1840 ENOG4105DEG Vwa containing coxe family protein Tcur_1842 ENOG4105KKX ATPase associated with various cellular activities aaa_5 Tcur_1853 ENOG4105D1F ATP-binding protein Tcur_1859 ENOG410846T CoA-transferase family III Tcur_1860 ENOG4105CHU acetyl-coa acetyltransferase Tcur_1862 ENOG4107QX3 carboxylase Tcur_1867 ENOG41067SE Tetr family transcriptional regulator Tcur_1868 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) Tcur_1873 ENOG4105CFG Acts as a chaperone (By similarity) Tcur_1876 ENOG4107W7X Aldolase Tcur_1878 ENOG4105D2B acyl-CoA dehydrogenase Tcur_1887 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_1888 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_1889 ENOG4105WQT MbtH domain protein Tcur_1891 ENOG4105E2K Glycosyl transferase (Group 1 Tcur_1895 ENOG4105D64 Mechanosensitive ion channel Tcur_1904 ENOG4108KZ5 Catalyzes the deacetylation of 1D-myo-inositol 2- acetamido-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) in the mycothiol biosynthesis pathway (By similarity) Tcur_1910 ENOG4105CY0 Metallo-Beta-Lactamase Tcur_1915 ENOG4105EYH Exonuclease Tcur_1927 ENOG4105UNS Pfam:DUF419 Tcur_1934 ENOG410901E Membrane Tcur_1936 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) Tcur_1956 ENOG4105CVR type I restriction-modification system Tcur_1960 ENOG4105BZ9 Cytochrome C oxidase, subunit I Tcur_1962 ENOG4108Z9K Osmotically inducible protein Tcur_1967 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase Tcur_1971 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) Tcur_1972 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tcur_1974 ENOG4105C1G acyl-Coa dehydrogenase Tcur_1975 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase Tcur_1977 ENOG4107QX3 carboxylase Tcur_1978 ENOG4108RZE Tetr family transcriptional regulator Tcur_1990 ENOG4105CQ7 ATP-dependent helicase Tcur_1991 ENOG410905P Pyridoxamine 5-phosphate Tcur_1998 ENOG4107SM8 Adenylate Guanylate cyclase Tcur_1999 ENOG41080R8 Conserved Protein Tcur_2001 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Tcur_2010 ENOG4105C57 major facilitator superfamily Tcur_2011 ENOG4105CHR reductase Tcur_2012 ENOG4107R33 ppx gppa phosphatase Tcur_2013 ENOG4105D9P serine threonine protein kinase Tcur_2018 ENOG4105ECY inositol monophosphatase Tcur_2034 ENOG4105D0M Protease HtpX homolog Tcur_2041 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) Tcur_2046 ENOG4105F0I Aminotransferase Tcur_2048 ENOG4105KF0 sporulation and cell division protein, SsgA Tcur_2052 ENOG4108BAS reductase Tcur_2060 ENOG4105WMR Protein CrcB homolog Tcur_2061 ENOG41083YR Protein CrcB homolog Tcur_2062 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Tcur_2063 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Tcur_2064 ENOG4107YEM Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Tcur_2066 ENOG4108YZ9 Urea amidohydrolase subunit gamma Tcur_2067 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein Tcur_2068 ENOG4108YZ9 Urea amidohydrolase subunit gamma Tcur_2083 ENOG4105YVS arsR family transcriptional regulator Tcur_2087 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tcur_2092 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Tcur_2095 ENOG4105C22 threonyL-tRNA synthetase Tcur_2100 ENOG4108VTU Cdp-alcohol phosphatidyltransferase Tcur_2101 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase Tcur_2102 ENOG4105E2K Glycosyl transferase (Group 1 Tcur_2105 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) Tcur_2107 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) Tcur_2108 ENOG4105CDY transcriptional regulatory protein Tcur_2109 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) Tcur_2110 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) Tcur_2111 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tcur_2113 ENOG4107RSV Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tcur_2114 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tcur_2115 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) Tcur_2116 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Tcur_2118 ENOG4105C99 atpase involved in dna repair Tcur_2119 ENOG4108ZR3 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity) Tcur_2120 ENOG4105C5X domain protein Tcur_2121 ENOG4105CUT histidyl-tRNA synthetase Tcur_2122 ENOG4105D06 uba thif-type nad fad binding protein Tcur_2124 ENOG4105C5S asparaginyl-tRNA synthetase Tcur_2128 ENOG4105C9M aspartyl-trna synthetase Tcur_2135 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) Tcur_2136 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Tcur_2138 ENOG4105E2X shikimate dehydrogenase Tcur_2139 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) Tcur_2140 ENOG41084BS 50S ribosomal protein L35 Tcur_2141 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) Tcur_2142 ENOG4108RWN rrna methyltransferase Tcur_2144 ENOG4105BZU Histidine kinase Tcur_2145 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) Tcur_2146 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) Tcur_2151 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Tcur_2152 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) Tcur_2153 ENOG4105CAS nag kinase Tcur_2154 ENOG4105C8Y Acetylornithine aminotransferase Tcur_2155 ENOG4105DBV ornithine carbamoyltransferase Tcur_2156 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) Tcur_2157 ENOG4105CDH Citrulline--aspartate ligase Tcur_2158 ENOG4105CH7 arginosuccinase Tcur_2159 ENOG4108VX5 3-methyladenine DNA glycosylase Tcur_2160 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) Tcur_2166 ENOG4105DSU hydrolase Tcur_2170 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) Tcur_2171 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) Tcur_2176 ENOG4108KMV Glycosyl transferase (Group 1 Tcur_2177 ENOG4105D2B acyl-CoA dehydrogenase Tcur_2179 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tcur_2183 ENOG4105F8J Adenylate Guanylate cyclase Tcur_2187 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tcur_2189 ENOG4105C5X domain protein Tcur_2191 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tcur_2193 ENOG4108UDB Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) Tcur_2194 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Tcur_2195 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) Tcur_2197 ENOG4105CIE May be required for sporulation (By similarity) Tcur_2198 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Tcur_2199 ENOG4105BZA Phosphoglycerate kinase Tcur_2200 ENOG4105CP7 Triose-phosphate isomerase Tcur_2205 ENOG41061JJ Peptidase family M23 Tcur_2208 ENOG4107XU2 6-phosphogluconolactonase (EC 3.1.1.31) Tcur_2211 ENOG4107QYV phosphohexose isomerase Tcur_2212 ENOG4107QYV phosphohexose isomerase Tcur_2213 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Tcur_2214 ENOG4105CV1 Transketolase (EC 2.2.1.1) Tcur_2215 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) Tcur_2218 ENOG4107AQZ Membrane Tcur_2220 ENOG4105CJ1 ABC, transporter Tcur_2221 ENOG4105CUB amino acid Tcur_2227 ENOG4105C3K feS assembly ATPase SufC Tcur_2228 ENOG4105C9B Cysteine desulfurase Tcur_2229 ENOG4108UNV SUF system FeS assembly protein, NifU family Tcur_2230 ENOG4105VG1 fes assembly suf system protein Tcur_2231 ENOG4105IIP Membrane Tcur_2232 ENOG4105BZU Histidine kinase Tcur_2233 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_2238 ENOG4105C5H ABC transporter Tcur_2240 ENOG4108VUG Enoyl-CoA hydratase Tcur_2241 ENOG4105BZ1 (ABC) transporter Tcur_2245 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) Tcur_2248 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tcur_2249 ENOG4108VW9 Membrane Tcur_2261 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tcur_2262 ENOG4107RCC Major Facilitator Superfamily Tcur_2264 ENOG4105EM7 Selenocysteine-specific translation elongation factor Tcur_2265 ENOG4105E0Y RtcB Protein Tcur_2266 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Tcur_2267 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) Tcur_2272 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) Tcur_2274 ENOG4105WKW Pfam:DUF1458 Tcur_2277 ENOG4105CHR reductase Tcur_2281 ENOG4105CPC Aldo Keto reductase Tcur_2282 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) Tcur_2287 ENOG4105C8N cysteinyl-tRNA synthetase Tcur_2288 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Tcur_2292 ENOG4105C3R Methionine synthase Tcur_2293 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 Tcur_2295 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tcur_2296 ENOG4105DEF Extracellular solute-binding protein, family 5 Tcur_2298 ENOG4105C3U ABC transporter Tcur_2299 ENOG4108JQ7 (ABC) transporter Tcur_2300 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_2301 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_2302 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_2303 ENOG4108ZGX Histidine kinase Tcur_2307 ENOG4105DHM ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis (By similarity) Tcur_2308 ENOG4105E5F proteasome Tcur_2309 ENOG4105WFD Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity) Tcur_2311 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Tcur_2312 ENOG4105F7N Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Tcur_2313 ENOG4105DVV Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity) Tcur_2316 ENOG4108FFZ Transcriptional regulator Tcur_2317 ENOG4107TMB Transcriptional regulator Tcur_2319 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) Tcur_2320 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Tcur_2322 ENOG4105HFS 5'-3' exonuclease Tcur_2325 ENOG4105EPJ extracellular solute-binding protein family 1 Tcur_2326 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component Tcur_2327 ENOG4105EB1 binding-protein-dependent transport systems inner membrane Component Tcur_2332 ENOG4105ETE Transcriptional regulator (LacI family Tcur_2333 ENOG4105EW9 transcriptional regulator AsnC family Tcur_2334 ENOG4105FBW Monooxygenase Tcur_2337 ENOG4105C1G acyl-Coa dehydrogenase Tcur_2339 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein Tcur_2340 ENOG4105FRY Dehydrogenase Tcur_2347 ENOG4107CHF 5,6-aminomutase beta subunit Tcur_2348 ENOG4108UYI beta-alanyl-CoA ammonia lyase Tcur_2350 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Tcur_2351 ENOG4105FS0 cytoplasmic membrane protein Tcur_2352 ENOG4105Q70 Tcur_2354 ENOG41082SX arsR family transcriptional regulator Tcur_2359 ENOG4106BQ7 Glycosyl Transferase Tcur_2363 ENOG4105XDV Tcur_2365 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) Tcur_2371 ENOG41061TZ Short-chain dehydrogenase reductase Sdr Tcur_2374 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Tcur_2376 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) Tcur_2377 ENOG4107QVM von Willebrand factor, type A Tcur_2379 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tcur_2382 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Tcur_2383 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tcur_2384 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tcur_2389 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Tcur_2391 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) Tcur_2396 ENOG4105F32 YngK protein Tcur_2398 ENOG4105E4F Isochorismate synthase Tcur_2402 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) Tcur_2403 ENOG4107TCW O-succinylbenzoate synthase Tcur_2406 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tcur_2412 ENOG4107QZF nitrite reductase NADPH large subunit Tcur_2413 ENOG4108IFG nitrite reductase, (NAD(P)H) Tcur_2414 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) Tcur_2417 ENOG4105DQQ Major facilitator superfamily MFS_1 Tcur_2422 ENOG4105W1N transcriptional regulator Tcur_2423 ENOG41080R8 Conserved Protein Tcur_2425 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Tcur_2429 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Tcur_2440 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) Tcur_2441 ENOG4106NMR serine protease Tcur_2442 ENOG4105KPK Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity) Tcur_2444 ENOG4107RCH Diaminopropionate ammonia-lyase Tcur_2447 ENOG4105CH6 catalase Tcur_2448 ENOG4108NBA ATP-dependent carboxylate-amine ligase (By similarity) Tcur_2451 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) Tcur_2456 ENOG4107HP6 Transcriptional regulator Tcur_2457 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase Tcur_2460 ENOG4108I69 Glycosyl transferases group 1 Tcur_2465 ENOG4108Z86 Glutamine amidotransferase Tcur_2468 ENOG4105BZU Histidine kinase Tcur_2469 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_2474 ENOG4108J2R molybdopterin oxidoreductase Tcur_2484 ENOG4106032 Glutathionylspermidine synthase Tcur_2487 ENOG4105C1G acyl-Coa dehydrogenase Tcur_2488 ENOG4105C3Q Glycosyl transferase, family 2 Tcur_2493 ENOG4108IUW ABC transporter Tcur_2495 ENOG4105N14 lysine exporter protein LysE YggA Tcur_2499 ENOG4105CC9 acyl-Coa dehydrogenase Tcur_2508 ENOG4107ZXU DSBA oxidoreductase Tcur_2510 ENOG4105C1G acyl-Coa dehydrogenase Tcur_2518 ENOG4105D9P serine threonine protein kinase Tcur_2545 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) Tcur_2554 ENOG4105CY0 Metallo-Beta-Lactamase Tcur_2561 ENOG4105CMG Carbohydrate kinase Tcur_2562 ENOG4105CVK Glutamate decarboxylase Tcur_2563 ENOG4108762 serine threonine protein kinase Tcur_2566 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Tcur_2568 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_2571 ENOG4107RSM transcriptional regulator Tcur_2587 ENOG4106YT9 Enoyl-CoA hydratase Tcur_2591 ENOG4107YCY Transcriptional regulator Tcur_2592 ENOG4105C29 acyl-CoA thioesterase Tcur_2597 ENOG4105D65 subunit l Tcur_2598 ENOG4105EVH UPF0753 protein Tcur_2599 ENOG4105CHH sulfate transporter Tcur_2603 ENOG4105D2B acyl-CoA dehydrogenase Tcur_2616 ENOG4108M0I Transcriptional regulator Tcur_2617 ENOG4105CIH Imidazole acetol-phosphate transaminase Tcur_2622 ENOG4105C0K Gdp-mannose 4,6-dehydratase Tcur_2625 ENOG4107R11 Transcriptional regulator Tcur_2629 ENOG4108KGH TRANSCRIPTIONal Tcur_2633 ENOG4105DTQ mandelate racemase muconate lactonizing Tcur_2638 ENOG41080RH Thioredoxin Tcur_2640 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Tcur_2644 ENOG4105BZU Histidine kinase Tcur_2645 ENOG4105BZU Histidine kinase Tcur_2647 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) Tcur_2650 ENOG4105BZM domain protein Tcur_2656 ENOG4108PJD permease Tcur_2667 ENOG4105CQ7 ATP-dependent helicase Tcur_2669 ENOG4105CPC Aldo Keto reductase Tcur_2670 ENOG4105E2R ROK family Tcur_2671 ENOG4105C2J ABC transporter Tcur_2672 ENOG4107RNG ABC transporter Tcur_2673 ENOG4105C2J ABC transporter Tcur_2674 ENOG4105DFW ABC transporter Tcur_2685 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Tcur_2695 ENOG4108IG5 Transcriptional regulator Tcur_2697 ENOG4105E39 Enoyl-CoA hydratase Tcur_2699 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) Tcur_2700 ENOG4105E39 Enoyl-CoA hydratase Tcur_2703 ENOG4108M8W Monooxygenase Tcur_2704 ENOG4108M8W Monooxygenase Tcur_2706 ENOG4105CC9 acyl-Coa dehydrogenase Tcur_2707 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_2709 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_2710 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_2712 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Tcur_2716 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Tcur_2717 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Tcur_2718 ENOG4108JQ6 ABC transporter Tcur_2719 ENOG4108J59 Extracellular solute-binding protein, family 5 Tcur_2720 ENOG4105E9F Enoyl-CoA hydratase Tcur_2727 ENOG4107S5I aldo keto reductase Tcur_2733 ENOG4105C7H Helicase, RecD TraA family Tcur_2747 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tcur_2757 ENOG4107ZQV short-chain dehydrogenase reductase Tcur_2761 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Tcur_2771 ENOG4105D8K carboxyl transferase Tcur_2772 ENOG4105CZS beta-ketoacyl synthase Tcur_2779 ENOG4105CSU acyl-Coa dehydrogenase Tcur_2791 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase Tcur_2797 ENOG4107U5X Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) Tcur_2816 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Tcur_2818 ENOG4108Z4X TRANSCRIPTIONal Tcur_2819 ENOG4105C0M Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity) Tcur_2822 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein Tcur_2826 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Tcur_2827 ENOG4105CAT Cytidine monophosphate kinase Tcur_2829 ENOG4105KHN chorismate mutase Tcur_2831 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Tcur_2832 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Tcur_2836 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) Tcur_2845 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) Tcur_2846 ENOG4105BZU Histidine kinase Tcur_2847 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Tcur_2851 ENOG4108ZJ4 polysaccharide deacetylase Tcur_2853 ENOG4105KA0 thioesterase Superfamily protein Tcur_2855 ENOG4108IV0 ABC, transporter Tcur_2856 ENOG4105C0Z ABC transporter Tcur_2857 ENOG4105CF8 branched-chain amino acid ABC transporter, permease Tcur_2858 ENOG4105C32 Amino acid ABC transporter (Permease) Tcur_2863 ENOG4108Z0Z intracellular protease Pfpi family Tcur_2866 ENOG4105CBC glutamate synthase Tcur_2870 ENOG4107TBN Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) Tcur_2873 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) Tcur_2874 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) Tcur_2875 ENOG4105DK0 Indole-3-glycerol phosphate synthase Tcur_2877 ENOG4105E3W Two component transcriptional regulator (Winged helix family Tcur_2879 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase Tcur_2880 ENOG4105VEQ Cold shock protein Tcur_2881 ENOG4105BZ1 (ABC) transporter Tcur_2882 ENOG4105BZ1 (ABC) transporter Tcur_2886 ENOG4105C1G acyl-Coa dehydrogenase Tcur_2890 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) Tcur_2891 ENOG4105KME endoribonuclease L-psp Tcur_2892 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase Tcur_2893 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) Tcur_2895 ENOG4105ECC imidazole-glycerol-phosphate dehydratase Tcur_2896 ENOG4105CIH Imidazole acetol-phosphate transaminase Tcur_2897 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) Tcur_2898 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Tcur_2899 ENOG4108Z66 YbaK ebsC protein Tcur_2901 ENOG4105C6Y Udp-glucose 6-dehydrogenase Tcur_2903 ENOG4105C0B DNA polymerase III (alpha subunit) Tcur_2906 ENOG4105CJP fad dependent oxidoreductase Tcur_2915 ENOG4105VZ9 UPF0235 protein Tcur_2916 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) Tcur_2921 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Tcur_2922 ENOG4105DFA alanine racemase domain protein Tcur_2923 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Tcur_2924 ENOG4105ME9 cell division protein FtsQ Tcur_2925 ENOG4105DFU Cell wall formation (By similarity) Tcur_2926 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) Tcur_2928 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Tcur_2929 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) Tcur_2931 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Tcur_2932 ENOG4105CJN penicillin-binding protein Tcur_2934 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Tcur_2935 ENOG4108V6E Cell division protein mraZ Tcur_2936 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tcur_2940 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) Tcur_2942 ENOG410803B Involved in the transcription termination process (By similarity) Tcur_2943 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) Tcur_2944 ENOG4105DC7 peptidase M24 Tcur_2945 ENOG4105DYW oxidoreductase Tcur_2946 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Tcur_2950 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) Tcur_2951 ENOG4105D49 3-dehydroquinate synthase Tcur_2952 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Tcur_2953 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Tcur_2957 ENOG4108S01 response regulator Tcur_2958 ENOG4105BZU Histidine kinase Tcur_2960 ENOG4105CJ1 ABC, transporter Tcur_2961 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase Tcur_2968 ENOG4105C2W permease Tcur_2970 ENOG4105G5A Protein of unknown function (DUF2877) Tcur_2971 ENOG4107R1Q Membrane protein FdrA Tcur_2972 ENOG4107REC cytoplasmic protein Tcur_2973 ENOG4107WI4 Aldose-1-epimerase Tcur_2975 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Tcur_2978 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family Tcur_2980 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) Tcur_2988 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Tcur_2993 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) Tcur_2994 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) Tcur_2995 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) Tcur_2997 ENOG4105DJV ribulose-phosphate 3-epimerase Tcur_2998 ENOG410841Q phosphoesterase PA-phosphatase related protein Tcur_3000 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) Tcur_3001 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Tcur_3003 ENOG4107RSZ Primosomal protein n' Tcur_3004 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP Tcur_3006 ENOG4105MTQ Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) Tcur_3007 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) Tcur_3009 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) Tcur_3010 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Tcur_3011 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) Tcur_3012 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Tcur_3013 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain Tcur_3014 ENOG4105CD3 dihydroorotase Tcur_3015 ENOG4105CXT aspartate transcarbamylase Tcur_3016 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) Tcur_3018 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tcur_3021 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) Tcur_3025 ENOG41080E2 ribosomal-protein-alanine acetyltransferase Tcur_3027 ENOG4105EAH synthase Tcur_3028 ENOG4106PBJ Serine threonine-protein kinase Pkn6 Tcur_3030 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) Tcur_3031 ENOG4105KYH transcriptional regulatory protein Tcur_3033 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Tcur_3034 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Tcur_3035 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) Tcur_3037 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) Tcur_3039 ENOG4108JPM phospho-2-dehydro-3-deoxyheptonate aldolase Tcur_3040 ENOG4108RNG Permease of the drug metabolite transporter Tcur_3042 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) Tcur_3043 ENOG4105CTQ phosphohexokinase Tcur_3044 ENOG4105E9Q Acyl-transferase Tcur_3047 ENOG4105DKQ ROK family Tcur_3059 ENOG4105JNK Glycosyl transferase (Group 1 Tcur_3060 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) Tcur_3061 ENOG4107EUI c reductase, iron-sulfur Tcur_3062 ENOG4107UDY cytochrome C Tcur_3063 ENOG4105CCU oxidase (Subunit III) Tcur_3065 ENOG4107S1N anthranilate phosphoribosyltransferase Tcur_3074 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 Tcur_3076 ENOG4105MCD Part of cytochrome c oxidase, its function is Tcur_3077 ENOG4105BZ9 Cytochrome C oxidase, subunit I Tcur_3078 ENOG4105CV4 Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity) Tcur_3083 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) Tcur_3087 ENOG4105CPC Aldo Keto reductase Tcur_3089 ENOG4108YZT Adenosylcobinamide kinase Tcur_3091 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) Tcur_3095 ENOG4105EC3 peptidase S51, dipeptidase E Tcur_3096 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) Tcur_3098 ENOG41082VC UPF0145 protein Tcur_3099 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) Tcur_3101 ENOG4105HHM rdd domain containing protein Tcur_3102 ENOG4105C5F glutamine synthetase Tcur_3103 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) Tcur_3105 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) Tcur_3106 ENOG4105C5F glutamine synthetase Tcur_3108 ENOG4105C4K Nad synthetase Tcur_3112 ENOG4105C57 major facilitator superfamily Tcur_3113 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) Tcur_3116 ENOG4106IPI cyclase, family Tcur_3121 ENOG4105C0H protease Tcur_3122 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_3123 ENOG4105FBW Monooxygenase Tcur_3124 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Tcur_3128 ENOG4105VT2 5-hydroxyisourate hydrolase Tcur_3129 ENOG4105C7N Xanthine uracil vitamin C permease Tcur_3130 ENOG4105BZW Glycerate kinase Tcur_3132 ENOG4107TB6 phosphoglycerate mutase Tcur_3133 ENOG4105VPX protein, conserved in bacteria Tcur_3136 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) Tcur_3137 ENOG4105CUB amino acid Tcur_3144 ENOG41083YR Protein CrcB homolog Tcur_3147 ENOG4108V1U phospholipid-binding protein Tcur_3153 ENOG4105CNF WD-40 repeat protein Tcur_3158 ENOG41064B9 (LipO)protein Tcur_3159 ENOG4107UWP Major facilitator superfamily MFS_1 Tcur_3162 ENOG4108IV0 ABC, transporter Tcur_3163 ENOG4105C0Z ABC transporter Tcur_3164 ENOG4105C32 Amino acid ABC transporter (Permease) Tcur_3167 ENOG4107QN1 sodium solute Tcur_3170 ENOG4107QN1 sodium solute Tcur_3172 ENOG4105DY9 regulatoR Tcur_3173 ENOG4108HRK Histidine kinase Tcur_3176 ENOG4105C5X domain protein Tcur_3180 ENOG4105PAD Hydrolase Tcur_3181 ENOG4108NIW Leucine export protein LeuE Tcur_3187 ENOG4105DAX Pfam:DUF2983 Tcur_3195 ENOG41082VC UPF0145 protein Tcur_3197 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) Tcur_3198 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) Tcur_3202 ENOG4108YZ9 Urea amidohydrolase subunit gamma Tcur_3203 ENOG4105KI2 Urea amidohydrolase subunit beta Tcur_3204 ENOG4105CQM Urea amidohydrolase subunit alpha Tcur_3206 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Tcur_3207 ENOG4105MT3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Tcur_3210 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Tcur_3211 ENOG4108KPJ rna polymerase sigma factor Tcur_3215 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein Tcur_3217 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Tcur_3218 ENOG4105BZP glycoside hydrolase 15-related Tcur_3221 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tcur_3224 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Tcur_3228 ENOG4105DIK (ABC) transporter Tcur_3231 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) Tcur_3232 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Tcur_3233 ENOG4105D4Y metalloprotease Tcur_3235 ENOG4107QXN Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tcur_3236 ENOG4108IV0 ABC, transporter Tcur_3237 ENOG4105C0Z ABC transporter Tcur_3240 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein Tcur_3241 ENOG4106V2I dimethylaminohydrolase Tcur_3243 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) Tcur_3246 ENOG4107VNR Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) Tcur_3248 ENOG4107YU2 histidine triad (hIT) protein Tcur_3252 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) Tcur_3253 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) Tcur_3261 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) Tcur_3262 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) Tcur_3267 ENOG4105KQC Competence protein Tcur_3268 ENOG4105CI2 imidazolone-5-propionate hydrolase Tcur_3269 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Tcur_3270 ENOG4107R9S Malate synthase Tcur_3271 ENOG4105CQB FAD linked oxidase domain protein Tcur_3272 ENOG4105CQB FAD linked oxidase domain protein Tcur_3273 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Tcur_3281 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Tcur_3282 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) Tcur_3285 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) Tcur_3286 ENOG4105CDA abc transporter atp-binding protein Tcur_3287 ENOG4105CT1 (ABC) transporter Tcur_3288 ENOG4108Q1T ABC transporter Tcur_3289 ENOG4105DRP amino acid AbC transporter Tcur_3291 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) Tcur_3294 ENOG4107KFM Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) Tcur_3301 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Tcur_3302 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Tcur_3303 ENOG4105WBV Transcriptional regulator Tcur_3304 ENOG4105CEV competence damage-inducible protein Tcur_3306 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) Tcur_3308 ENOG4107QZI cell division protein FtsK Tcur_3309 ENOG4105CN5 Metallo-Beta-Lactamase Tcur_3310 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Tcur_3318 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Tcur_3321 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) Tcur_3322 ENOG41082T9 Membrane Tcur_3323 ENOG4105C1V Peptidase, M16 Tcur_3324 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) Tcur_3325 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) Tcur_3327 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Tcur_3328 ENOG4105SFS phosphoesterase RecJ domain protein Tcur_3329 ENOG4107ZPY Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) Tcur_3331 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) Tcur_3333 ENOG4107Z1I Required for maturation of 30S ribosomal subunits (By similarity) Tcur_3342 ENOG4105CC9 acyl-Coa dehydrogenase Tcur_3346 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta Tcur_3347 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase Tcur_3352 ENOG4108RZE Tetr family transcriptional regulator Tcur_3356 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) Tcur_3365 ENOG4106IPI cyclase, family Tcur_3370 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) Tcur_3372 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) Tcur_3374 ENOG41082BV acetyltransferase Tcur_3377 ENOG4107TYH extracellular solute-binding protein family 1 Tcur_3379 ENOG4105C26 Dehydrogenase Tcur_3380 ENOG4105C8Y Acetylornithine aminotransferase Tcur_3381 ENOG4105KZX Pterin carbinolamine dehydratase Tcur_3384 ENOG4106PVI ATP-dependent carboxylate-amine ligase (By similarity) Tcur_3392 ENOG4105CJP fad dependent oxidoreductase Tcur_3393 ENOG4105D38 putrescine abc transporter Tcur_3394 ENOG4105F38 ABC transporter, permease Tcur_3396 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Tcur_3400 ENOG4105FDK ABC transporter Tcur_3404 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs Tcur_3407 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) Tcur_3408 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) Tcur_3409 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) Tcur_3410 ENOG4105CE9 30S ribosomal protein S2 Tcur_3413 ENOG41080R2 UPF0102 protein Tcur_3414 ENOG4105C0P Mg chelatase subunit ChlI Tcur_3417 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) Tcur_3419 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) Tcur_3420 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Tcur_3421 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Tcur_3422 ENOG41082KU UPF0109 protein Tcur_3423 ENOG4105K5M 30s ribosomal protein S16 Tcur_3425 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Tcur_3429 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) Tcur_3431 ENOG4108375 Acylphosphatase (EC 3.6.1.7) Tcur_3432 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Tcur_3433 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) Tcur_3434 ENOG41084BZ 50S ribosomal protein L32 Tcur_3436 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) Tcur_3437 ENOG4106H78 methyltransferase Tcur_3439 ENOG4105VB9 50S ribosomal protein l28 Tcur_3441 ENOG4105DWF phosphomethylpyrimidine kinase Tcur_3447 ENOG4107S5I aldo keto reductase Tcur_3449 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) Tcur_3450 ENOG41081JD Transcriptional regulator Tcur_3452 ENOG4105J7D transcriptional regulator Tcur_3453 ENOG4105E39 Enoyl-CoA hydratase Tcur_3454 ENOG4107SCA Formamidase (EC 3.5.1.49) Tcur_3455 ENOG4105CPF Cell wall formation (By similarity) Tcur_3456 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase Tcur_3458 ENOG4105ME0 Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity) Tcur_3460 ENOG4105K70 DNA-binding protein Tcur_3462 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tcur_3463 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) Tcur_3464 ENOG41069M3 Transcriptional regulator Tcur_3470 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) Tcur_3471 ENOG4105DIV Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity) Tcur_3473 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Tcur_3474 ENOG4105F2C Acetyl-CoA acetyltransferase Tcur_3475 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_3481 ENOG4108KC2 acyl-Coa dehydrogenase Tcur_3483 ENOG4105X7H acyl-CoA dehydrogenase Tcur_3484 ENOG4105J5T Amp-dependent synthetase and ligase Tcur_3485 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Tcur_3487 ENOG4108IV0 ABC, transporter Tcur_3488 ENOG4105C0Z ABC transporter Tcur_3489 ENOG4105C32 Amino acid ABC transporter (Permease) Tcur_3491 ENOG4105CHR reductase Tcur_3494 ENOG4105D2B acyl-CoA dehydrogenase Tcur_3495 ENOG4105F2C Acetyl-CoA acetyltransferase Tcur_3498 ENOG4108QIU Dehydrogenase Tcur_3500 ENOG4108SGK Tetr family transcriptional regulator Tcur_3506 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tcur_3508 ENOG4108KC1 acyl-Coa dehydrogenase Tcur_3512 ENOG4105J5T Amp-dependent synthetase and ligase Tcur_3515 ENOG4107EFR Flavocytochrome c Tcur_3518 ENOG4107SET aldo keto reductase Tcur_3521 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein Tcur_3522 ENOG41088PD hydrolase Tcur_3523 ENOG4105MXW flavin reductase domain protein, FMN-binding Tcur_3525 ENOG4105DYW oxidoreductase Tcur_3529 ENOG4105EYF MMPL domain protein Tcur_3534 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) Tcur_3537 ENOG4105D5U fad dependent oxidoreductase Tcur_3538 ENOG4105ERH Fumarylacetoacetate hydrolase Tcur_3542 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) Tcur_3543 ENOG4105CM2 brancheD-chain amino acid aminotransferase Tcur_3544 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Tcur_3550 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) Tcur_3552 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Tcur_3558 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tcur_3559 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) Tcur_3560 ENOG41081AP Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) Tcur_3562 ENOG4105BZU Histidine kinase Tcur_3563 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) Tcur_3567 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) Tcur_3570 ENOG4108IND Tetr family transcriptional regulator Tcur_3572 ENOG4105F8C transglutaminase domain-containing protein Tcur_3573 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tcur_3574 ENOG4105C10 Electron transfer flavoprotein Tcur_3577 ENOG4108762 serine threonine protein kinase Tcur_3579 ENOG4108W6C Dehydrogenase Tcur_3580 ENOG4105C0D helicase Tcur_3581 ENOG4107XWB Zinc finger, swim domain protein Tcur_3582 ENOG4108IUN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) Tcur_3583 ENOG4105EP6 Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity) Tcur_3585 ENOG41070F3 Catalyzes the ATP-dependent phosphorylation of maltose to maltose 1-phosphate. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, GlgE and GlgB (By similarity) Tcur_3598 ENOG41073TP transcriptional regulator Tcur_3603 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) Tcur_3609 ENOG4105MXW flavin reductase domain protein, FMN-binding Tcur_3610 ENOG4105CJA serine threonine protein kinase Tcur_3615 ENOG4105CI2 imidazolone-5-propionate hydrolase Tcur_3617 ENOG4105CE7 Amidase, hydantoinase carbamoylase family Tcur_3618 ENOG4105CGP Urocanate hydratase Tcur_3619 ENOG4105C84 Histidine ammonia-lyase Tcur_3621 ENOG4107258 Transcriptional regulator Tcur_3625 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tcur_3634 ENOG4105E90 ABC transporter Tcur_3635 ENOG4105R40 Glycine betaine carnitine choline Tcur_3636 ENOG4108IJ8 ABC transporter Tcur_3637 ENOG4105ETE Transcriptional regulator (LacI family Tcur_3638 ENOG41067HS methyltransferase Tcur_3639 ENOG4108V75 Glutamine amidotransferase Tcur_3640 ENOG4105E46 N-alpha,N-alpha,N-alpha-trimethyl-L-histidine metabolic process Tcur_3643 ENOG4105X7H acyl-CoA dehydrogenase Tcur_3644 ENOG4108RK3 acyl-Coa dehydrogenase Tcur_3645 ENOG4108SGK Tetr family transcriptional regulator Tcur_3646 ENOG4105DTD Dehydrogenase Tcur_3650 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase Tcur_3651 ENOG4106A3M Cytochrome p-450 Tcur_3654 ENOG4105F2C Acetyl-CoA acetyltransferase Tcur_3655 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Tcur_3658 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Tcur_3659 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tcur_3672 ENOG4105KF3 Short-chain dehydrogenase reductase Sdr Tcur_3675 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Tcur_3678 ENOG4105VUN Transcriptional regulator Tcur_3680 ENOG4105CB2 alcohol dehydrogenase Tcur_3682 ENOG4105E5Q amino acid AbC transporter Tcur_3683 ENOG4106TNF Periplasmic binding protein Tcur_3687 ENOG4108VEQ Superoxide dismutase Tcur_3690 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Tcur_3693 ENOG4105CBD Diacylglycerol kinase Tcur_3697 ENOG4105FDP GntR family transcriptional regulator Tcur_3698 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) Tcur_3699 ENOG4107WHG Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) Tcur_3702 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Tcur_3703 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase Tcur_3705 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase Tcur_3707 ENOG4105WMN AntiSigma factor Tcur_3708 ENOG4105EMN RNA polymerase sigma factor Tcur_3709 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) Tcur_3711 ENOG4108RAV Conserved protein Tcur_3714 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Tcur_3718 ENOG4107TK4 histidinol-phosphate phosphatase Tcur_3722 ENOG4105CHR reductase Tcur_3724 ENOG4107RCI amp-dependent synthetase and ligase Tcur_3727 ENOG41063PX domain protein Tcur_3730 ENOG4105DJZ UPF0182 protein Tcur_3740 ENOG4105WBQ Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tcur_3742 ENOG4105C29 acyl-CoA thioesterase Tcur_3748 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Tcur_3749 ENOG4105DUU IucA IucC family protein Tcur_3750 ENOG4105DBM Siderophore biosynthesis protein Tcur_3752 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tcur_3753 ENOG4105C4R Atp-dependent dna helicase Tcur_3767 ENOG4107R13 MMPL domain protein Tcur_3770 ENOG4105CHR reductase Tcur_3775 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tcur_3796 ENOG4105KPY Small multidrug resistance protein Tcur_3807 ENOG41068W2 Cytochrome p-450 Tcur_3809 ENOG4105GWZ Roadblock lc7 family protein Tcur_3812 ENOG4108YV4 Universal stress protein Tcur_3814 ENOG4105CIK Amidinotransferase Tcur_3819 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Tcur_3821 ENOG4105C28 cystathionine Tcur_3830 ENOG4105CY3 ABC transporter, permease Tcur_3833 ENOG4108IG5 Transcriptional regulator Tcur_3834 ENOG4107Z3H Transcriptional regulator, TetR family Tcur_3835 ENOG4107RN6 Monooxygenase Tcur_3839 ENOG4105CEY Amp-dependent synthetase and ligase Tcur_3842 ENOG4105DZP Membrane-associated zinc metalloprotease Tcur_3845 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Tcur_3846 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) Tcur_3847 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) Tcur_3850 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Tcur_3857 ENOG4105D7K pfkb domain protein Tcur_3858 ENOG4105F8D glycoside hydrolase family 4 Tcur_3864 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) Tcur_3865 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) Tcur_3867 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) Tcur_3874 ENOG4108Q7D Domain of unknown function (DUF2017) Tcur_3875 ENOG4105KEN Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) Tcur_3877 ENOG4108RWI nicotinamidase Tcur_3878 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) Tcur_3882 ENOG4108UJU UPF0301 protein Tcur_3890 ENOG4105CHU acetyl-coa acetyltransferase Tcur_3896 ENOG4105CPT Alpha beta hydrolase Tcur_3900 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase Tcur_3903 ENOG4105CYV Cleaves both 3' and 5' ssDNA extremities of branched DNA structures (By similarity) Tcur_3906 ENOG4107XZ0 Peptidase M50 Tcur_3915 ENOG410825K Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) Tcur_3916 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) Tcur_3917 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) Tcur_3918 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) Tcur_3919 ENOG4108T62 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) Tcur_3920 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Tcur_3921 ENOG4105ZA1 atp synthase Tcur_3930 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Tcur_3931 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) Tcur_3932 ENOG4105VFB Binds the 23S rRNA (By similarity) Tcur_3933 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_3936 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) Tcur_3938 ENOG4107R5I Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) Tcur_3939 ENOG4105D6E homoserine dehydrogenase Tcur_3940 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Tcur_3942 ENOG4108UNF response regulator Tcur_3943 ENOG4105VTR Integrase Tcur_3951 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Tcur_3953 ENOG41076PI Short-chain dehydrogenase reductase Sdr Tcur_3956 ENOG4105C75 arginyL-tRNA synthetase Tcur_3960 ENOG4105DZ1 carboxypeptidase Tcur_3961 ENOG4105CVK Glutamate decarboxylase Tcur_3964 ENOG410829K Lysine exporter protein (Lyse ygga) Tcur_3965 ENOG4108SGK Tetr family transcriptional regulator Tcur_3967 ENOG4105D9P serine threonine protein kinase Tcur_3968 ENOG4105D9P serine threonine protein kinase Tcur_3969 ENOG4105D9P serine threonine protein kinase Tcur_3970 ENOG4105CRK lysyL-tRNA synthetase Tcur_3978 ENOG4105CHR reductase Tcur_3980 ENOG41080W3 amp-dependent synthetase and ligase Tcur_3981 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) Tcur_3989 ENOG4108M6P methyltransferase Tcur_3992 ENOG41073B4 coagulation factor 5 8 type domain-containing protein Tcur_3994 ENOG4105CKK Glycosyl transferase, family 2 Tcur_3998 ENOG4105D2B acyl-CoA dehydrogenase Tcur_4000 ENOG4105EXN Sulfate transport protein CysZ Tcur_4003 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) Tcur_4006 ENOG4105CAK Cell division ATP-binding protein ftsE Tcur_4009 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) Tcur_4010 ENOG4106A0S Tcur_4011 ENOG4105C7I Dehydrogenase Tcur_4013 ENOG4105K4H Nlp p60 protein Tcur_4014 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tcur_4016 ENOG4105C26 Dehydrogenase Tcur_4019 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 Tcur_4021 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate Tcur_4022 ENOG4106KNT transcriptional regulator Tcur_4025 ENOG4105D17 glycoside hydrolase, family 3 domain protein Tcur_4026 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Tcur_4027 ENOG410849S phosphocarrier protein (HPr) Tcur_4028 ENOG4105C5Y PTS System Tcur_4029 ENOG4105CI1 PTS System Tcur_4030 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Tcur_4031 ENOG4105CE4 GlcNAc 6-P deacetylase Tcur_4032 ENOG4105FDP GntR family transcriptional regulator Tcur_4033 ENOG4105CI1 PTS System Tcur_4035 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Tcur_4037 ENOG4105T0Z Conserved Protein Tcur_4039 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Tcur_4040 ENOG4105MJ2 Competence protein Tcur_4041 ENOG4105G3P Lipoprotein lpqB Tcur_4042 ENOG4105BZU Histidine kinase Tcur_4043 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tcur_4047 ENOG4108WQ6 secreted protein Tcur_4048 ENOG4105C7R Atpase associated with various cellular activities aaa_3 Tcur_4055 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Tcur_4056 ENOG4105C3E May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity) Tcur_4061 ENOG41086CI Bifunctional phosphoglucose phosphomannose isomerase Tcur_4062 ENOG4105W49 UPF0434 protein Tcur_4069 ENOG4107RGC Glycosyl transferase, family 2 Tcur_4070 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Tcur_4072 ENOG4105EIH LPPG Fo 2-phospho-L-lactate transferase Tcur_4075 ENOG4105DKF Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity) Tcur_4076 ENOG4105DND Transcriptional regulator Tcur_4082 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tcur_4084 ENOG4105K63 Thioredoxin Tcur_4092 ENOG4107Y2G Glycosyl transferase (Group 1 Tcur_4093 ENOG4105CKK Glycosyl transferase, family 2 Tcur_4096 ENOG4107TB5 TRANSCRIPTIONal Tcur_4097 ENOG4108TGC Acyltransferase Tcur_4098 ENOG4107SJB teichoic acid biosynthesis Tcur_4104 ENOG4105EEM helicase Tcur_4108 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Tcur_4111 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) Tcur_4114 ENOG4108KGH TRANSCRIPTIONal Tcur_4117 ENOG4105K4P CoA-binding domain protein Tcur_4121 ENOG41065SU Two-component system sensor kinase Tcur_4122 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Tcur_4125 ENOG4108UQY Iron-storage protein Tcur_4126 ENOG4108QER Adenylate cyclase Tcur_4129 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) Tcur_4130 ENOG4105D8K carboxyl transferase Tcur_4147 ENOG4105EC2 ftsk spoIIIe Tcur_4155 ENOG41082YX Transcriptional regulator, arsr family Tcur_4160 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_4163 ENOG4108J9M Transporter Tcur_4165 ENOG4105K6B K06886 hemoglobin Tcur_4175 ENOG4108JIK carboxylase Tcur_4183 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Tcur_4185 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) Tcur_4191 ENOG4105DIH basic membrane Tcur_4192 ENOG4108JQ9 ABC transporter Tcur_4193 ENOG4105UIB (ABC) transporter Tcur_4195 ENOG4105CHR reductase Tcur_4199 ENOG4107RM1 amidohydrolase Tcur_4200 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) Tcur_4201 ENOG4105DZ1 carboxypeptidase Tcur_4204 ENOG4105C31 Tryptophanyl-tRNA synthetase Tcur_4206 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Tcur_4209 ENOG4105D9Z Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Tcur_4213 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Tcur_4215 ENOG4105DC1 bifunctional purine biosynthesis protein purh Tcur_4221 ENOG4105CMV Succinyl-CoA synthetase subunit beta Tcur_4226 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_4238 ENOG4108KQJ Type 11 methyltransferase Tcur_4240 ENOG4108I69 Glycosyl transferases group 1 Tcur_4243 ENOG4105D3R alkyl hydroperoxide reductase Tcur_4244 ENOG4108X7C Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Tcur_4247 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Tcur_4249 ENOG4105C26 Dehydrogenase Tcur_4250 ENOG4108IG5 Transcriptional regulator Tcur_4251 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Tcur_4252 ENOG4107QVP Dehydrogenase Tcur_4256 ENOG4108MMM RNA Polymerase Tcur_4257 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) Tcur_4258 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) Tcur_4261 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) Tcur_4262 ENOG41080E2 ribosomal-protein-alanine acetyltransferase Tcur_4265 ENOG4108097 ATP-binding protein Tcur_4267 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Tcur_4269 ENOG41082KK Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) Tcur_4273 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) Tcur_4274 ENOG4105CS9 pantothenic acid kinase Tcur_4278 ENOG4105DA5 (ABC) transporter Tcur_4282 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) Tcur_4283 ENOG4108UJD 30S ribosomal protein S9 Tcur_4284 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) Tcur_4285 ENOG4105K4I Scp-like extracellular Tcur_4288 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) Tcur_4289 ENOG4108ZT0 50S ribosomal protein l17 Tcur_4290 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tcur_4291 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) Tcur_4292 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) Tcur_4293 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits Tcur_4294 ENOG41067V7 50S ribosomal protein L36 Tcur_4295 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) Tcur_4297 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) Tcur_4300 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) Tcur_4301 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Tcur_4302 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) Tcur_4303 ENOG410849U 50S ribosomal protein L30 Tcur_4304 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) Tcur_4305 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) Tcur_4306 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) Tcur_4307 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) Tcur_4308 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) Tcur_4309 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits Tcur_4310 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) Tcur_4311 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) Tcur_4312 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal Tcur_4313 ENOG41082SA 50s ribosomal protein l29 Tcur_4314 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) Tcur_4315 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) Tcur_4316 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) Tcur_4317 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) Tcur_4318 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity Tcur_4319 ENOG4105KZR One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) Tcur_4320 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) Tcur_4321 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) Tcur_4322 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Tcur_4323 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) Tcur_4324 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) Tcur_4325 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) Tcur_4326 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) Tcur_4329 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_4330 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_4337 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tcur_4338 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) Tcur_4348 ENOG4105CY3 ABC transporter, permease Tcur_4349 ENOG4105DHJ ABC, transporter Tcur_4350 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) Tcur_4351 ENOG4108VZM 50s ribosomal protein L10 Tcur_4352 ENOG4105QCJ Lipoprotein Tcur_4353 ENOG4105QCJ Lipoprotein Tcur_4354 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) Tcur_4355 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) Tcur_4361 ENOG4107R4N Cell wall formation (By similarity) Tcur_4363 ENOG410900P UPF0336 protein Tcur_4364 ENOG4105WDJ 50S ribosomal protein L33 Tcur_4367 ENOG4105C1G acyl-Coa dehydrogenase Tcur_4374 ENOG4108VPT UPF0234 protein Tcur_4376 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) Tcur_4377 ENOG4105D0M Protease HtpX homolog Tcur_4378 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4379 ENOG4105C8S subunit m Tcur_4381 ENOG41082X4 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4383 ENOG4108M11 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4386 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Tcur_4387 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4388 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Tcur_4391 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein Tcur_4392 ENOG4105DQU oxidoreductase, subunit beta Tcur_4393 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Tcur_4396 ENOG4105C0R drug resistance transporter emrb qaca subfamily Tcur_4398 ENOG4105CMR udp-glucose 4-epimerase Tcur_4402 ENOG4107QXP Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) Tcur_4405 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4407 ENOG4105D65 subunit l Tcur_4408 ENOG4105M5H NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4409 ENOG4105DF2 NADH dehydrogenase subunit j Tcur_4410 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4411 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) Tcur_4412 ENOG4108IEH NADH dehydrogenase subunit g Tcur_4415 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4416 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain Tcur_4417 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4421 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tcur_4428 ENOG4105CRE cytochrome C Tcur_4429 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Tcur_4430 ENOG4107QIV Cytochrome c biogenesis protein Tcur_4432 ENOG4108RH7 phosphoglycerate mutase Tcur_4433 ENOG4105JQN Transcriptional regulator Tcur_4434 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase Tcur_4435 ENOG4107TPY serine threonine protein kinase Tcur_4437 ENOG4105D52 delta-aminolevulinic acid dehydratase Tcur_4438 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Tcur_4439 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) Tcur_4440 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) Tcur_4441 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) Tcur_4446 ENOG4108RXW HAD-superfamily subfamily IB hydrolase Tcur_4451 ENOG4108XFF Tcur_4452 ENOG4105DGU Histone deacetylase Tcur_4455 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_4456 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_4457 ENOG4105ENT Efflux transporter rnd family, mfp subunit Tcur_4459 ENOG4105II7 pyrroline-5-carboxylate reductase Tcur_4461 ENOG4108KGH TRANSCRIPTIONal Tcur_4463 ENOG4108IG5 Transcriptional regulator Tcur_4464 ENOG4105EY0 Xylose isomerase domain protein TIM barrel Tcur_4465 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) Tcur_4466 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Tcur_4467 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) Tcur_4475 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Tcur_4482 ENOG4105CRK lysyL-tRNA synthetase Tcur_4483 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) Tcur_4484 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase Tcur_4485 ENOG4108IYU L-aspartate oxidase Tcur_4486 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) Tcur_4487 ENOG4107QQT Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Tcur_4488 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase Tcur_4490 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Tcur_4491 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_4492 ENOG4105BZU Histidine kinase Tcur_4497 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4500 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Tcur_4504 ENOG4105EUJ GTP cyclohydrolase i Tcur_4507 ENOG4107RD1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) Tcur_4509 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family Tcur_4510 ENOG4105F0N pyrophosphate phospho-hydrolase Tcur_4511 ENOG4105ZXU NLP P60 protein Tcur_4520 ENOG4108QBF Transcriptional regulator Tcur_4522 ENOG4105M18 -acetyltransferase Tcur_4536 ENOG4105VTR Integrase Tcur_4539 ENOG4105MA4 psp1 domain protein Tcur_4542 ENOG4105KJF protein tyrosine phosphatase Tcur_4543 ENOG4107QRG dna polymerase iii Tcur_4544 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) Tcur_4545 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Tcur_4547 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Tcur_4550 ENOG4105CIR epoxide hydrolase Tcur_4551 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_4568 ENOG4105ETE Transcriptional regulator (LacI family Tcur_4581 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Tcur_4583 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) Tcur_4588 ENOG4105CQS hydrogenase expression formation protein HypD Tcur_4594 ENOG4105DPX Hydrogenase, large subunit Tcur_4596 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) Tcur_4602 ENOG4105DIM ABC transporter Tcur_4603 ENOG4105CIG ABC transporter Tcur_4604 ENOG4108IG5 Transcriptional regulator Tcur_4611 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tcur_4612 ENOG4105D2B acyl-CoA dehydrogenase Tcur_4613 ENOG4105CC9 acyl-Coa dehydrogenase Tcur_4615 ENOG4105CHR reductase Tcur_4616 ENOG4105CHU acetyl-coa acetyltransferase Tcur_4617 ENOG41073TP transcriptional regulator Tcur_4618 ENOG4105E39 Enoyl-CoA hydratase Tcur_4621 ENOG4105EA8 2-Nitropropane dioxygenase Tcur_4625 ENOG4105KJM monovalent cation h antiporter subunit g Tcur_4626 ENOG41080TA Multiple resistance and ph regulation protein f Tcur_4627 ENOG4105SC1 monovalent cation H antiporter subunit E Tcur_4628 ENOG4108JPZ Monovalent cation H antiporter subunit D Tcur_4629 ENOG4105MKQ Monovalent cation H antiporter subunit C Tcur_4630 ENOG4105D65 subunit l Tcur_4636 ENOG4108M9J MaoC like domain protein Tcur_4637 ENOG4105IYB L-carnitine dehydratase bile acid-inducible protein F Tcur_4645 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) Tcur_4660 ENOG4105BZU Histidine kinase Tcur_4661 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_4665 ENOG4105C37 (CBS) domain Tcur_4670 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component Tcur_4671 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component Tcur_4682 ENOG4105BZU Histidine kinase Tcur_4689 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) Tcur_4702 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit Tcur_4704 ENOG4107TDF Formate hydrogenlyase subunit 4 Tcur_4706 ENOG4108JPZ Monovalent cation H antiporter subunit D Tcur_4707 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) Tcur_4710 ENOG41066YJ Beta-lactamase Tcur_4712 ENOG4108JQ7 (ABC) transporter Tcur_4718 ENOG4105KK4 UPF0060 membrane protein Tcur_4719 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) Tcur_4722 ENOG4108JJB ABC transporter Tcur_4729 ENOG4105WH1 Two component transcriptional regulator luxr family Tcur_4735 ENOG4108Z6Z Transcriptional regulator Tcur_4736 ENOG4105F27 Major Facilitator Tcur_4737 ENOG4108JJ8 (ABC) transporter Tcur_4738 ENOG4108JJ9 ABC, transporter Tcur_4739 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Tcur_4740 ENOG4105C4M (Ubiquinol oxidase) subunit I Tcur_4749 ENOG4105DU6 RNA polymerase Tcur_4750 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) Tcur_4752 ENOG4105GR3 Histidine kinase Tcur_4765 ENOG4105K6T rare lipoprotein A Tcur_4772 ENOG4108SGK Tetr family transcriptional regulator Tcur_4777 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) Tcur_4787 ENOG4108KPJ rna polymerase sigma factor Tcur_4795 ENOG4107YBY Hydrolase Tcur_4796 ENOG4105DEI Mannitol dehydrogenase Tcur_4797 ENOG4107U2T alpha beta Tcur_4801 ENOG4105PNM synthesis protein Tcur_4802 ENOG4105C3J Cysteine desulfurase Tcur_4810 ENOG4105DB1 molybdopterin oxidoreductase Tcur_4811 ENOG4105E6M Sulphatase-modifying factor protein Tcur_4815 ENOG4105DKW ABC transporter Tcur_4817 ENOG4105W8D rdd domain containing protein Tcur_4820 ENOG4105EAC phosphoserine phosphatase Tcur_4823 ENOG4105M4E phosphohistidine phosphatase, SixA Tcur_4825 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Tcur_4826 ENOG4105EAY pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Tcur_4827 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) Tcur_4828 ENOG4105WN5 stage II sporulation protein Tcur_4829 ENOG4108I5C dEAD DEAH box helicase Tcur_4841 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) Tcur_4842 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Tcur_4844 ENOG4105D74 hydrolase Tcur_4847 ENOG4105P8F nudix hydrolase Tcur_4850 ENOG4105IJJ transcriptional regulator, crp fnr family Tcur_4851 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Tcur_4853 ENOG4105KME endoribonuclease L-psp Tcur_4867 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Tcur_4870 ENOG41083VQ Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) Tcur_4871 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) Tcur_4875 ENOG4105FDP GntR family transcriptional regulator Tcur_4876 ENOG4105FDP GntR family transcriptional regulator Tcur_4880 ENOG4108Z6Z Transcriptional regulator Tcur_4886 ENOG4105CFH Aspartokinase Tcur_4896 ENOG41067SE Tetr family transcriptional regulator Tcur_4897 ENOG4105QNJ serralysin (EC 3.4.24.40) Tcur_4902 ENOG4105BZ1 (ABC) transporter Tcur_4919 ENOG4107RGJ metallophosphoesterase Tcur_4921 ENOG4105BZ4 penicillin-binding protein Tcur_4928 ENOG4105C31 Tryptophanyl-tRNA synthetase Tcur_4937 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) Tcur_4941 ENOG4108Z6B deaminase Tcur_4943 ENOG4107QI1 Mate efflux family protein Tcur_4946 ENOG4105K9Q Binds to the 23S rRNA (By similarity) Tcur_4947 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) Tcur_4949 ENOG410829C Binds together with S18 to 16S ribosomal RNA (By similarity) Tcur_4955 ENOG4105BZ4 penicillin-binding protein Tcur_4960 ENOG4105C3M thioredoxin reductase Tcur_4968 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Tcur_4971 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Tcur_4975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Tcur_4976 ENOG4105CPF Cell wall formation (By similarity) Tcur_4978 ENOG4107QJE Chromosome Partitioning Protein Tcur_4980 ENOG4107XUG Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) Tcur_4982 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Tcur_4983 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) Tcur_4984 ENOG4105XH8 RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) Tcur_4985 ENOG41084CH 50S ribosomal protein l34