locus-tag	class	description
Tcur_0002	COG0592	DNA-directed DNA polymerase activity
Tcur_0003	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Tcur_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tcur_0005	COG5512	Zn-ribbon-containing possibly RNA-binding protein and truncated derivatives
Tcur_0007	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tcur_0025	COG2252	PERMEase
Tcur_0026	COG1253	flavin adenine dinucleotide binding
Tcur_0032	COG3973	AAA domain
Tcur_0033	COG0667	Aldo Keto reductase
Tcur_0046	COG2188	Transcriptional regulator
Tcur_0052	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tcur_0058	COG0705	Rhomboid family
Tcur_0063	COG0515	serine threonine protein kinase
Tcur_0064	COG0515	serine threonine protein kinase
Tcur_0065	COG0768	penicillin binding
Tcur_0068	COG1716	ATPase activity
Tcur_0075	COG4558	Periplasmic binding protein
Tcur_0076	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tcur_0077	COG1120	ATPase activity
Tcur_0079	COG5398	heme oxygenase
Tcur_0084	COG0475	glutathione-regulated potassium exporter activity
Tcur_0089	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Tcur_0091	COG2608	mercury ion transmembrane transporter activity
Tcur_0093	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Tcur_0096	COG2235	arginine
Tcur_0098	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_0107	COG0028	Belongs to the TPP enzyme family
Tcur_0110	COG2197	response regulator
Tcur_0111	COG4585	Histidine kinase
Tcur_0113	COG2409	Drug exporters of the RND superfamily
Tcur_0119	COG5650	phosphatidylinositol metabolic process
Tcur_0121	COG0077	Prephenate dehydratase
Tcur_0123	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tcur_0126	COG0561	phosphatase activity
Tcur_0129	COG2815	serine threonine protein kinase
Tcur_0129	COG0515	serine threonine protein kinase
Tcur_0130	COG0840	transmembrane signaling receptor activity
Tcur_0131	COG1280	lysine exporter protein (LysE YggA)
Tcur_0132	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tcur_0142	COG0655	NAD(P)H dehydrogenase (quinone) activity
Tcur_0146	COG1595	DNA-templated transcription, initiation
Tcur_0150	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tcur_0154	COG2197	response regulator
Tcur_0160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_0161	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tcur_0162	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tcur_0172	COG0419	ATPase involved in DNA repair
Tcur_0177	COG0584	glycerophosphoryl diester phosphodiesterase
Tcur_0186	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tcur_0190	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tcur_0193	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tcur_0194	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tcur_0196	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tcur_0197	COG0151	Belongs to the GarS family
Tcur_0200	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tcur_0201	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tcur_0203	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tcur_0206	COG1733	regulation of RNA biosynthetic process
Tcur_0207	COG0191	fructose-bisphosphate aldolase activity
Tcur_0210	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tcur_0217	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tcur_0218	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tcur_0219	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tcur_0220	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_0221	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tcur_0224	COG2814	Major facilitator Superfamily
Tcur_0234	COG0542	response to heat
Tcur_0235	COG0789	Transcriptional regulator
Tcur_0236	COG0484	heat shock protein binding
Tcur_0237	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tcur_0238	COG0443	Heat shock 70 kDa protein
Tcur_0242	COG2181	nitrate reductase activity
Tcur_0242	COG0247	lactate metabolic process
Tcur_0244	COG0717	Belongs to the dCTP deaminase family
Tcur_0256	COG2272	Belongs to the type-B carboxylesterase lipase family
Tcur_0259	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Tcur_0261	COG3025	triphosphatase activity
Tcur_0261	COG5607	PFAM CHAD domain containing protein
Tcur_0268	COG4221	oxidoreductase activity
Tcur_0271	COG1960	acyl-CoA dehydrogenase activity
Tcur_0277	COG1733	regulation of RNA biosynthetic process
Tcur_0278	COG0477	Major facilitator Superfamily
Tcur_0280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tcur_0282	COG4941	Belongs to the sigma-70 factor family
Tcur_0284	COG0515	serine threonine protein kinase
Tcur_0288	COG0167	dihydroorotate dehydrogenase activity
Tcur_0289	COG2890	protein-(glutamine-N5) methyltransferase activity
Tcur_0290	COG0860	N-Acetylmuramoyl-L-alanine amidase
Tcur_0298	COG2949	membrane
Tcur_0299	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Tcur_0312	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tcur_0314	COG0047	phosphoribosylformylglycinamidine synthase activity
Tcur_0316	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tcur_0318	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_0327	COG1012	belongs to the aldehyde dehydrogenase family
Tcur_0329	COG0022	dehydrogenase e1 component
Tcur_0330	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tcur_0333	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
Tcur_0334	COG1966	Carbon starvation protein
Tcur_0342	COG1120	ATPase activity
Tcur_0343	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tcur_0346	COG1309	transcriptional regulator
Tcur_0347	COG1136	(ABC) transporter
Tcur_0347	COG0577	efflux transmembrane transporter activity
Tcur_0350	COG1271	oxidase subunit
Tcur_0351	COG1294	oxidase, subunit
Tcur_0352	COG4988	ABC transporter
Tcur_0354	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Tcur_0356	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tcur_0357	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Tcur_0358	COG1120	ATPase activity
Tcur_0364	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tcur_0365	COG1021	2,3-dihydroxybenzoate-AMP ligase
Tcur_0369	COG1169	isochorismate synthase
Tcur_0370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Tcur_0376	COG0515	serine threonine protein kinase
Tcur_0376	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tcur_0382	COG0515	serine threonine protein kinase
Tcur_0396	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tcur_0399	COG0515	serine threonine protein kinase
Tcur_0402	COG1653	transport
Tcur_0405	COG0633	Ferredoxin
Tcur_0405	COG0543	2 iron, 2 sulfur cluster binding
Tcur_0406	COG1151	hydroxylamine reductase activity
Tcur_0413	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Tcur_0419	COG2815	serine threonine protein kinase
Tcur_0419	COG0515	serine threonine protein kinase
Tcur_0437	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Tcur_0438	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Tcur_0440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tcur_0443	COG0420	3'-5' exonuclease activity
Tcur_0447	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tcur_0448	COG1177	transmembrane transport
Tcur_0449	COG3842	ATPase activity
Tcur_0453	COG1960	acyl-CoA dehydrogenase activity
Tcur_0454	COG0045	succinate-CoA ligase (ADP-forming) activity
Tcur_0454	COG1042	CoA-binding domain protein
Tcur_0454	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tcur_0455	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_0458	COG3629	intracellular signal transduction
Tcur_0458	COG3903	Transcriptional regulator
Tcur_0461	COG2205	protein histidine kinase activity
Tcur_0464	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tcur_0465	COG1116	anion transmembrane transporter activity
Tcur_0466	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tcur_0467	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_0470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tcur_0493	COG3189	MarR family transcriptional regulator
Tcur_0495	COG0326	Molecular chaperone. Has ATPase activity
Tcur_0504	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Tcur_0505	COG0045	succinate-CoA ligase (ADP-forming) activity
Tcur_0505	COG1042	CoA-binding domain protein
Tcur_0505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tcur_0508	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tcur_0511	COG1309	transcriptional regulator
Tcur_0519	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tcur_0520	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tcur_0521	COG1278	Cold shock
Tcur_0532	COG1414	Transcriptional regulator
Tcur_0533	COG1414	Transcriptional regulator
Tcur_0538	COG1942	4-Oxalocrotonate Tautomerase
Tcur_0541	COG1960	acyl-CoA dehydrogenase activity
Tcur_0548	COG2365	Tyrosine phosphatase family
Tcur_0549	COG0215	cysteine-tRNA ligase activity
Tcur_0551	COG0384	phenazine biosynthesis protein PhzF
Tcur_0554	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tcur_0559	COG1773	rubredoxin
Tcur_0560	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tcur_0565	COG2072	flavoprotein involved in K transport
Tcur_0567	COG0539	negative regulation of cytoplasmic translation
Tcur_0575	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_0577	COG1024	Enoyl-CoA hydratase
Tcur_0578	COG0745	RESPONSE REGULATOR receiver
Tcur_0579	COG2205	protein histidine kinase activity
Tcur_0580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tcur_0582	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tcur_0583	COG0242	peptide deformylase activity
Tcur_0586	COG0464	growth
Tcur_0589	COG0306	phosphate transporter
Tcur_0590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tcur_0591	COG0581	inorganic phosphate transmembrane transporter activity
Tcur_0594	COG0456	acetyltransferase
Tcur_0595	COG0745	RESPONSE REGULATOR receiver
Tcur_0605	COG1404	Belongs to the peptidase S8 family
Tcur_0607	COG1674	ftsk spoiiie
Tcur_0610	COG4842	Belongs to the WXG100 family
Tcur_0611	COG4842	Belongs to the WXG100 family
Tcur_0624	COG1316	TRANSCRIPTIONal
Tcur_0627	COG3119	arylsulfatase activity
Tcur_0630	COG1216	Glycosyl transferase, family 2
Tcur_0631	COG0438	transferase activity, transferring glycosyl groups
Tcur_0636	COG1216	Glycosyl transferase, family 2
Tcur_0640	COG1215	transferase activity, transferring glycosyl groups
Tcur_0642	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Tcur_0643	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Tcur_0643	COG2755	lipolytic protein G-D-S-L family
Tcur_0649	COG3442	glutamine amidotransferase
Tcur_0653	COG4044	May play a role in the intracellular transport of hydrophobic ligands
Tcur_0655	COG0354	folic acid binding
Tcur_0657	COG1490	D-aminoacyl-tRNA deacylase activity
Tcur_0658	COG3246	L-lysine catabolic process to acetate
Tcur_0662	COG2321	neutral zinc metallopeptidase
Tcur_0667	COG1309	transcriptional regulator
Tcur_0668	COG2409	Drug exporters of the RND superfamily
Tcur_0678	COG1396	sequence-specific DNA binding
Tcur_0683	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
Tcur_0687	COG3384	dioxygenase
Tcur_0688	COG0702	epimerase
Tcur_0689	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tcur_0695	COG0438	transferase activity, transferring glycosyl groups
Tcur_0697	COG0588	phosphoglycerate mutase activity
Tcur_0699	COG5002	protein histidine kinase activity
Tcur_0704	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tcur_0705	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
Tcur_0706	COG0179	Fumarylacetoacetate (FAA) hydrolase
Tcur_0711	COG0215	cysteine-tRNA ligase activity
Tcur_0723	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_0724	COG0179	Fumarylacetoacetate (FAA) hydrolase
Tcur_0725	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Tcur_0729	COG1454	alcohol dehydrogenase
Tcur_0731	COG0514	ATP-dependent DNA helicase (RecQ)
Tcur_0732	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Tcur_0744	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tcur_0744	COG1672	PFAM Archaeal ATPase
Tcur_0745	COG0667	Aldo Keto reductase
Tcur_0748	COG0431	NADPH-dependent FMN reductase
Tcur_0749	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tcur_0752	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Tcur_0754	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tcur_0757	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tcur_0758	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tcur_0761	COG2508	Transcriptional regulator
Tcur_0768	COG1053	succinate dehydrogenase
Tcur_0770	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_0773	COG1024	Enoyl-CoA hydratase
Tcur_0774	COG1960	acyl-CoA dehydrogenase activity
Tcur_0775	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_0776	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_0777	COG0640	Transcriptional regulator
Tcur_0780	COG0443	Heat shock 70 kDa protein
Tcur_0791	COG1404	Belongs to the peptidase S8 family
Tcur_0796	COG1695	Transcriptional regulator
Tcur_0797	COG0515	serine threonine protein kinase
Tcur_0798	COG1595	DNA-templated transcription, initiation
Tcur_0799	COG0457	Tetratricopeptide repeat
Tcur_0804	COG0459	protein refolding
Tcur_0810	COG1061	Type III restriction enzyme res subunit
Tcur_0812	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_0815	COG1309	transcriptional regulator
Tcur_0818	COG1278	Cold shock
Tcur_0826	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Tcur_0832	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Tcur_0835	COG0259	pyridoxamine-phosphate oxidase activity
Tcur_0842	COG0183	Belongs to the thiolase family
Tcur_0847	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tcur_0848	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tcur_0848	COG1672	PFAM Archaeal ATPase
Tcur_0850	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tcur_0851	COG1012	belongs to the aldehyde dehydrogenase family
Tcur_0852	COG1012	belongs to the aldehyde dehydrogenase family
Tcur_0854	COG0416	fatty acid biosynthetic process
Tcur_0858	COG1881	PFAM PEBP family protein
Tcur_0863	COG0442	prolyl-tRNA aminoacylation
Tcur_0867	COG1595	DNA-templated transcription, initiation
Tcur_0871	COG0612	Peptidase, M16
Tcur_0872	COG1366	Belongs to the anti-sigma-factor antagonist family
Tcur_0879	COG1733	regulation of RNA biosynthetic process
Tcur_0880	COG2910	NAD(P)H-binding
Tcur_0881	COG2197	response regulator
Tcur_0883	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tcur_0884	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tcur_0886	COG0135	phosphoribosylanthranilate isomerase activity
Tcur_0887	COG1280	lysine exporter protein (LysE YggA)
Tcur_0892	COG0483	inositol monophosphate 1-phosphatase activity
Tcur_0902	COG1970	mechanosensitive ion channel activity
Tcur_0904	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tcur_0905	COG2409	Drug exporters of the RND superfamily
Tcur_0910	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Tcur_0911	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Tcur_0913	COG0315	cyclic pyranopterin monophosphate synthase activity
Tcur_0914	COG0521	Mo-molybdopterin cofactor biosynthetic process
Tcur_0924	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tcur_0925	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tcur_0935	COG1203	CRISPR-associated helicase, Cas3
Tcur_0937	COG1518	maintenance of DNA repeat elements
Tcur_0938	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tcur_0939	COG0606	chelatase, subunit chli
Tcur_0943	COG1857	crispr-associated protein
Tcur_0946	COG1518	maintenance of DNA repeat elements
Tcur_0948	COG0546	phosphoglycolate phosphatase activity
Tcur_0949	COG0412	Dienelactone hydrolase
Tcur_0953	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tcur_0954	COG1309	transcriptional regulator
Tcur_0956	COG1960	acyl-CoA dehydrogenase activity
Tcur_0959	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_0960	COG1960	acyl-CoA dehydrogenase activity
Tcur_0961	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tcur_0965	COG0406	alpha-ribazole phosphatase activity
Tcur_0968	COG0501	Belongs to the peptidase M48B family
Tcur_0970	COG0598	Magnesium transport protein CorA
Tcur_0976	COG0463	Glycosyl transferase, family 2
Tcur_0979	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tcur_0980	COG0084	hydrolase, TatD family'
Tcur_0982	COG0741	lytic transglycosylase activity
Tcur_0984	COG1595	DNA-templated transcription, initiation
Tcur_0985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tcur_0987	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tcur_0990	COG0488	(ABC) transporter
Tcur_0992	COG4106	trans-aconitate 2-methyltransferase activity
Tcur_0994	COG1309	transcriptional regulator
Tcur_0997	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tcur_0998	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tcur_0999	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tcur_1000	COG0193	aminoacyl-tRNA hydrolase activity
Tcur_1001	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tcur_1002	COG1218	3'(2'),5'-bisphosphate nucleotidase
Tcur_1015	COG3291	Pkd domain containing protein
Tcur_1015	COG4412	M6 family metalloprotease domain protein
Tcur_1020	COG0730	response to heat
Tcur_1021	COG0529	Catalyzes the synthesis of activated sulfate
Tcur_1026	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tcur_1029	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tcur_1029	COG1703	isobutyryl-CoA mutase activity
Tcur_1029	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tcur_1033	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tcur_1034	COG1116	anion transmembrane transporter activity
Tcur_1036	COG0148	phosphopyruvate hydratase activity
Tcur_1040	COG1573	uracil-dna glycosylase
Tcur_1041	COG1252	NADH dehydrogenase
Tcur_1042	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tcur_1045	COG0183	Belongs to the thiolase family
Tcur_1049	COG2409	Drug exporters of the RND superfamily
Tcur_1053	COG4867	von Willebrand factor, type A
Tcur_1054	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
Tcur_1057	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tcur_1061	COG1714	RDD family
Tcur_1062	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Tcur_1064	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tcur_1066	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tcur_1070	COG1234	tRNA 3'-trailer cleavage
Tcur_1071	COG1331	Highly conserved protein containing a thioredoxin domain
Tcur_1075	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tcur_1076	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tcur_1078	COG0114	fumarate hydratase activity
Tcur_1080	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Tcur_1080	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Tcur_1088	COG1722	exodeoxyribonuclease VII activity
Tcur_1089	COG1570	exodeoxyribonuclease VII activity
Tcur_1091	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tcur_1093	COG1322	Protein conserved in bacteria
Tcur_1095	COG0012	GTP binding
Tcur_1111	COG0542	response to heat
Tcur_1116	COG1053	succinate dehydrogenase
Tcur_1118	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tcur_1122	COG1053	succinate dehydrogenase
Tcur_1124	COG0784	Response regulator, receiver
Tcur_1125	COG4251	negative regulation of phosphorylation
Tcur_1127	COG1132	(ABC) transporter
Tcur_1128	COG1132	(ABC) transporter
Tcur_1131	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tcur_1135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tcur_1136	COG1522	sequence-specific DNA binding
Tcur_1137	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Tcur_1143	COG0215	cysteine-tRNA ligase activity
Tcur_1144	COG2226	methyltransferase
Tcur_1144	COG1073	alpha beta
Tcur_1146	COG1024	Enoyl-CoA hydratase
Tcur_1147	COG0726	polysaccharide deacetylase
Tcur_1156	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tcur_1158	COG1960	acyl-CoA dehydrogenase activity
Tcur_1167	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tcur_1171	COG2171	N-acyltransferase activity
Tcur_1172	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tcur_1173	COG1611	Belongs to the LOG family
Tcur_1174	COG1611	Belongs to the LOG family
Tcur_1175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tcur_1178	COG2818	Glycosylase
Tcur_1180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tcur_1183	COG1595	DNA-templated transcription, initiation
Tcur_1186	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tcur_1187	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Tcur_1190	COG2239	Acts as a magnesium transporter
Tcur_1192	COG2301	Belongs to the HpcH HpaI aldolase family
Tcur_1199	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tcur_1200	COG0513	Belongs to the DEAD box helicase family
Tcur_1202	COG0515	serine threonine protein kinase
Tcur_1206	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tcur_1207	COG3285	dna ligase
Tcur_1207	COG1793	dna ligase
Tcur_1209	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Tcur_1211	COG0438	transferase activity, transferring glycosyl groups
Tcur_1212	COG0463	Glycosyl transferase, family 2
Tcur_1212	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Tcur_1214	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Tcur_1219	COG2259	Doxx family
Tcur_1220	COG0613	PHP domain protein
Tcur_1222	COG0789	Transcriptional regulator
Tcur_1223	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_1225	COG1295	ribonuclease BN
Tcur_1227	COG1960	acyl-CoA dehydrogenase activity
Tcur_1228	COG1024	Enoyl-CoA hydratase
Tcur_1234	COG0776	regulation of translation
Tcur_1235	COG0737	Belongs to the 5'-nucleotidase family
Tcur_1238	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_1241	COG0427	acetyl-CoA hydrolase
Tcur_1253	COG2197	response regulator
Tcur_1254	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Tcur_1257	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tcur_1263	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tcur_1268	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tcur_1271	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
Tcur_1272	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tcur_1275	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Tcur_1288	COG1492	cobalamin metabolic process
Tcur_1300	COG2197	response regulator
Tcur_1301	COG4585	Histidine kinase
Tcur_1303	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_1311	COG1797	cobyrinic acid a,c-diamide synthase activity
Tcur_1315	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tcur_1322	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tcur_1323	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Tcur_1323	COG1648	precorrin-2 dehydrogenase activity
Tcur_1327	COG0629	single-stranded DNA binding
Tcur_1328	COG0745	RESPONSE REGULATOR receiver
Tcur_1328	COG3706	GGDEF domain
Tcur_1331	COG2271	Major facilitator Superfamily
Tcur_1334	COG0668	transmembrane transport
Tcur_1338	COG2226	methyltransferase
Tcur_1339	COG1505	serine-type exopeptidase activity
Tcur_1344	COG0129	dihydroxy-acid dehydratase activity
Tcur_1346	COG0154	amidase activity
Tcur_1350	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Tcur_1354	COG1122	ATPase activity
Tcur_1359	COG3850	Histidine kinase
Tcur_1359	COG0642	Histidine kinase
Tcur_1360	COG1012	belongs to the aldehyde dehydrogenase family
Tcur_1367	COG2814	Major facilitator Superfamily
Tcur_1374	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tcur_1375	COG1116	anion transmembrane transporter activity
Tcur_1383	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_1385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tcur_1387	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tcur_1395	COG0443	Heat shock 70 kDa protein
Tcur_1397	COG1100	Small GTP-binding protein
Tcur_1406	COG0210	DNA helicase
Tcur_1407	COG2815	serine threonine protein kinase
Tcur_1407	COG0515	serine threonine protein kinase
Tcur_1422	COG3209	COG3209 Rhs family protein
Tcur_1433	COG2124	cytochrome p450
Tcur_1453	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Tcur_1454	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tcur_1455	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tcur_1457	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tcur_1460	COG2205	protein histidine kinase activity
Tcur_1461	COG0745	RESPONSE REGULATOR receiver
Tcur_1472	COG0183	Belongs to the thiolase family
Tcur_1475	COG1960	acyl-CoA dehydrogenase activity
Tcur_1476	COG1960	acyl-CoA dehydrogenase activity
Tcur_1485	COG2197	response regulator
Tcur_1488	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_1494	COG1201	RNA secondary structure unwinding
Tcur_1498	COG4245	von Willebrand factor, type A
Tcur_1504	COG3311	Transcriptional regulator
Tcur_1505	COG1569	PIN domain
Tcur_1523	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tcur_1524	COG0778	Nitroreductase
Tcur_1528	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tcur_1529	COG0740	serine-type endopeptidase activity
Tcur_1530	COG0740	serine-type endopeptidase activity
Tcur_1531	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tcur_1532	COG2197	response regulator
Tcur_1535	COG0525	valine-tRNA ligase activity
Tcur_1536	COG0285	dihydrofolate synthase activity
Tcur_1538	COG0105	UTP biosynthetic process
Tcur_1539	COG1077	Cell shape determining protein MreB Mrl
Tcur_1542	COG0768	penicillin binding
Tcur_1543	COG0772	Belongs to the SEDS family
Tcur_1546	COG1530	ribonuclease E activity
Tcur_1547	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tcur_1548	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tcur_1549	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tcur_1551	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Tcur_1552	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Tcur_1553	COG0501	Belongs to the peptidase M48B family
Tcur_1554	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tcur_1555	COG0799	negative regulation of ribosome biogenesis
Tcur_1556	COG0328	RNA-DNA hybrid ribonuclease activity
Tcur_1556	COG0406	alpha-ribazole phosphatase activity
Tcur_1560	COG1683	Conserved Protein
Tcur_1561	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tcur_1562	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_1574	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Tcur_1576	COG1595	DNA-templated transcription, initiation
Tcur_1578	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Tcur_1579	COG2267	carboxylic ester hydrolase activity
Tcur_1581	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_1582	COG0495	leucyl-tRNA aminoacylation
Tcur_1583	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tcur_1585	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tcur_1587	COG0656	L-ascorbic acid biosynthetic process
Tcur_1591	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tcur_1592	COG0464	growth
Tcur_1603	COG3903	Transcriptional regulator
Tcur_1603	COG3629	intracellular signal transduction
Tcur_1606	COG2770	Histidine kinase
Tcur_1606	COG2208	phosphoserine phosphatase activity
Tcur_1607	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tcur_1609	COG3022	response to hydroperoxide
Tcur_1612	COG0531	amino acid
Tcur_1618	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tcur_1620	COG1131	(ABC) transporter
Tcur_1622	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Tcur_1623	COG4585	Histidine kinase
Tcur_1626	COG0514	ATP-dependent DNA helicase (RecQ)
Tcur_1628	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tcur_1628	COG1042	CoA-binding domain protein
Tcur_1628	COG0045	succinate-CoA ligase (ADP-forming) activity
Tcur_1639	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tcur_1640	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tcur_1643	COG2267	carboxylic ester hydrolase activity
Tcur_1644	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Tcur_1646	COG0432	Pfam Uncharacterised protein family UPF0047
Tcur_1650	COG0572	uridine kinase
Tcur_1651	COG2197	response regulator
Tcur_1652	COG4585	Histidine kinase
Tcur_1653	COG3268	Saccharopine dehydrogenase
Tcur_1654	COG0583	DNA-binding transcription factor activity
Tcur_1655	COG1850	ribulose-bisphosphate carboxylase activity
Tcur_1656	COG4451	ribulose bisphosphate carboxylase, small
Tcur_1657	COG0464	growth
Tcur_1659	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tcur_1664	COG1619	proteins homologs of microcin C7 resistance protein MccF
Tcur_1666	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tcur_1671	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tcur_1673	COG0406	alpha-ribazole phosphatase activity
Tcur_1673	COG0328	RNA-DNA hybrid ribonuclease activity
Tcur_1675	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Tcur_1679	COG0659	secondary active sulfate transmembrane transporter activity
Tcur_1681	COG1881	PFAM PEBP family protein
Tcur_1682	COG1252	NADH dehydrogenase
Tcur_1685	COG3402	PFAM membrane-flanked domain
Tcur_1690	COG0739	heme binding
Tcur_1694	COG0745	RESPONSE REGULATOR receiver
Tcur_1695	COG2205	protein histidine kinase activity
Tcur_1701	COG0525	valine-tRNA ligase activity
Tcur_1703	COG0706	membrane insertase activity
Tcur_1705	COG0756	dUTP diphosphatase activity
Tcur_1710	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Tcur_1711	COG0569	domain protein
Tcur_1713	COG0569	domain protein
Tcur_1714	COG0531	amino acid
Tcur_1715	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tcur_1723	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tcur_1727	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_1728	COG1280	lysine exporter protein (LysE YggA)
Tcur_1733	COG2723	6-phospho-beta-galactosidase activity
Tcur_1734	COG0395	ABC-type sugar transport system, permease component
Tcur_1739	COG0366	Alpha amylase catalytic
Tcur_1742	COG0129	dihydroxy-acid dehydratase activity
Tcur_1743	COG0837	glucose binding
Tcur_1744	COG0800	Aldolase
Tcur_1746	COG0515	serine threonine protein kinase
Tcur_1746	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tcur_1749	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Tcur_1752	COG3663	DNA glycosylase
Tcur_1754	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Tcur_1755	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tcur_1757	COG0493	'glutamate synthase
Tcur_1758	COG0531	amino acid
Tcur_1759	COG1024	Enoyl-CoA hydratase
Tcur_1759	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tcur_1760	COG0183	Belongs to the thiolase family
Tcur_1763	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Tcur_1768	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tcur_1769	COG3540	Alkaline phosphatase
Tcur_1771	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tcur_1772	COG1595	DNA-templated transcription, initiation
Tcur_1782	COG1960	acyl-CoA dehydrogenase activity
Tcur_1786	COG0175	sulfate reduction
Tcur_1788	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tcur_1791	COG2409	Drug exporters of the RND superfamily
Tcur_1802	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Tcur_1802	COG1116	anion transmembrane transporter activity
Tcur_1803	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tcur_1807	COG1132	(ABC) transporter
Tcur_1808	COG1316	TRANSCRIPTIONal
Tcur_1812	COG0386	Belongs to the glutathione peroxidase family
Tcur_1818	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tcur_1826	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tcur_1829	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tcur_1829	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tcur_1834	COG2072	flavoprotein involved in K transport
Tcur_1835	COG1597	lipid kinase activity
Tcur_1840	COG3552	Protein containing von Willebrand factor type A (VWA) domain
Tcur_1842	COG0714	Associated with various cellular activities
Tcur_1853	COG0489	protein tyrosine kinase activity
Tcur_1859	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tcur_1860	COG0183	Belongs to the thiolase family
Tcur_1862	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tcur_1868	COG0778	Nitroreductase
Tcur_1873	COG0443	Heat shock 70 kDa protein
Tcur_1876	COG0235	Class ii aldolase
Tcur_1878	COG1960	acyl-CoA dehydrogenase activity
Tcur_1884	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tcur_1887	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Tcur_1888	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Tcur_1889	COG3251	PFAM MbtH domain protein
Tcur_1891	COG0438	transferase activity, transferring glycosyl groups
Tcur_1895	COG0668	transmembrane transport
Tcur_1904	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Tcur_1910	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tcur_1914	COG0420	3'-5' exonuclease activity
Tcur_1915	COG0419	ATPase involved in DNA repair
Tcur_1921	COG0515	serine threonine protein kinase
Tcur_1927	COG2315	Protein conserved in bacteria
Tcur_1934	COG3304	Inner membrane component domain
Tcur_1936	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Tcur_1956	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Tcur_1960	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tcur_1962	COG1764	response to oxidative stress
Tcur_1967	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Tcur_1971	COG0235	Class ii aldolase
Tcur_1971	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tcur_1972	COG0477	Major facilitator Superfamily
Tcur_1974	COG1960	acyl-CoA dehydrogenase activity
Tcur_1977	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tcur_1978	COG1309	transcriptional regulator
Tcur_1990	COG1643	Atp-dependent helicase
Tcur_1991	COG3467	pyridoxamine 5'-phosphate
Tcur_1998	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tcur_1998	COG1672	PFAM Archaeal ATPase
Tcur_1999	COG1556	Lactate utilization protein
Tcur_2001	COG0247	lactate metabolic process
Tcur_2010	COG0477	Major facilitator Superfamily
Tcur_2012	COG0248	Ppx GppA phosphatase
Tcur_2034	COG0501	Belongs to the peptidase M48B family
Tcur_2041	COG0516	GMP reductase activity
Tcur_2041	COG0517	IMP dehydrogenase activity
Tcur_2045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Tcur_2045	COG0512	Glutamine amidotransferase of anthranilate synthase
Tcur_2046	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tcur_2052	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_2060	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tcur_2061	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tcur_2062	COG0829	nickel cation binding
Tcur_2063	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Tcur_2064	COG0830	nickel cation binding
Tcur_2068	COG0831	urea catabolic process
Tcur_2069	COG4413	Urea transporter
Tcur_2083	COG0640	Transcriptional regulator
Tcur_2087	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tcur_2094	COG0477	Major facilitator Superfamily
Tcur_2095	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tcur_2101	COG1560	Kdo2-lipid A biosynthetic process
Tcur_2102	COG0438	transferase activity, transferring glycosyl groups
Tcur_2105	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tcur_2107	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tcur_2108	COG0217	transcriptional regulatory protein
Tcur_2109	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tcur_2110	COG0632	four-way junction helicase activity
Tcur_2111	COG2255	four-way junction helicase activity
Tcur_2113	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tcur_2114	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tcur_2115	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tcur_2116	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tcur_2118	COG1196	nuclear chromosome segregation
Tcur_2119	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Tcur_2120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tcur_2121	COG0124	histidyl-tRNA synthetase
Tcur_2122	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Tcur_2124	COG0017	Asparaginyl-tRNA synthetase
Tcur_2128	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tcur_2135	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tcur_2136	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tcur_2138	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Tcur_2139	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tcur_2140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tcur_2141	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tcur_2142	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tcur_2144	COG4191	Histidine kinase
Tcur_2145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tcur_2146	COG0072	phenylalanine-tRNA ligase activity
Tcur_2146	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tcur_2147	COG0488	(ABC) transporter
Tcur_2151	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Tcur_2152	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Tcur_2153	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Tcur_2154	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tcur_2155	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tcur_2156	COG1438	arginine binding
Tcur_2157	COG0137	argininosuccinate synthase activity
Tcur_2158	COG0165	Argininosuccinate lyase
Tcur_2159	COG2094	Belongs to the DNA glycosylase MPG family
Tcur_2160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tcur_2166	COG0647	UMP catabolic process
Tcur_2170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tcur_2171	COG0497	DNA recombination
Tcur_2176	COG0438	transferase activity, transferring glycosyl groups
Tcur_2177	COG1960	acyl-CoA dehydrogenase activity
Tcur_2179	COG0542	response to heat
Tcur_2183	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tcur_2183	COG2972	Histidine kinase
Tcur_2187	COG3383	formate dehydrogenase (NAD+) activity
Tcur_2189	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tcur_2191	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tcur_2193	COG0723	plastoquinol--plastocyanin reductase activity
Tcur_2194	COG0322	excinuclease ABC activity
Tcur_2195	COG1660	Displays ATPase and GTPase activities
Tcur_2197	COG1481	regulation of sporulation
Tcur_2198	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tcur_2199	COG0126	phosphoglycerate kinase activity
Tcur_2200	COG0149	triose-phosphate isomerase activity
Tcur_2201	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tcur_2205	COG0739	heme binding
Tcur_2208	COG0363	glucosamine-6-phosphate deaminase activity
Tcur_2211	COG0166	Belongs to the GPI family
Tcur_2212	COG0166	Belongs to the GPI family
Tcur_2213	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tcur_2214	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Tcur_2215	COG0109	protoheme IX farnesyltransferase activity
Tcur_2218	COG5006	permease, DMT superfamily
Tcur_2220	COG1131	(ABC) transporter
Tcur_2221	COG0531	amino acid
Tcur_2227	COG0396	ATPase activity
Tcur_2228	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tcur_2229	COG0822	iron-sulfur transferase activity
Tcur_2230	COG2151	metal-sulfur cluster biosynthetic enzyme
Tcur_2232	COG4585	Histidine kinase
Tcur_2233	COG2197	response regulator
Tcur_2238	COG0488	(ABC) transporter
Tcur_2240	COG1024	Enoyl-CoA hydratase
Tcur_2241	COG1132	(ABC) transporter
Tcur_2245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tcur_2248	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tcur_2249	COG2364	Membrane
Tcur_2262	COG2814	Major facilitator Superfamily
Tcur_2265	COG1690	Belongs to the RtcB family
Tcur_2266	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tcur_2267	COG0746	molybdenum cofactor guanylyltransferase activity
Tcur_2272	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tcur_2274	COG3360	Dodecin
Tcur_2277	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_2281	COG0667	Aldo Keto reductase
Tcur_2282	COG1968	undecaprenyl-diphosphatase activity
Tcur_2287	COG0215	cysteine-tRNA ligase activity
Tcur_2288	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Tcur_2292	COG0646	methionine synthase
Tcur_2292	COG1410	methionine synthase
Tcur_2293	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tcur_2296	COG0747	negative chemotaxis
Tcur_2299	COG4608	Belongs to the ABC transporter superfamily
Tcur_2300	COG1136	(ABC) transporter
Tcur_2300	COG0577	efflux transmembrane transporter activity
Tcur_2301	COG1136	(ABC) transporter
Tcur_2302	COG2197	response regulator
Tcur_2303	COG4585	Histidine kinase
Tcur_2305	COG0517	IMP dehydrogenase activity
Tcur_2305	COG1994	Peptidase M50
Tcur_2307	COG1222	aaa ATPase
Tcur_2308	COG4122	O-methyltransferase activity
Tcur_2311	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tcur_2312	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tcur_2313	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tcur_2316	COG2378	regulation of single-species biofilm formation
Tcur_2317	COG2378	regulation of single-species biofilm formation
Tcur_2320	COG0805	protein transport
Tcur_2322	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tcur_2325	COG1653	transport
Tcur_2326	COG1175	transmembrane transport
Tcur_2327	COG0395	ABC-type sugar transport system, permease component
Tcur_2333	COG1522	sequence-specific DNA binding
Tcur_2337	COG1960	acyl-CoA dehydrogenase activity
Tcur_2339	COG1509	lysine 2,3-aminomutase activity
Tcur_2340	COG0604	alcohol dehydrogenase
Tcur_2347	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tcur_2348	COG1607	acyl-coa hydrolase
Tcur_2350	COG1216	Glycosyl transferase, family 2
Tcur_2351	COG3030	protein affecting phage T7 exclusion by the F plasmid
Tcur_2354	COG0640	Transcriptional regulator
Tcur_2363	COG0535	radical SAM domain protein
Tcur_2365	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Tcur_2371	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_2374	COG0584	glycerophosphoryl diester phosphodiesterase
Tcur_2375	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tcur_2377	COG2304	oxidoreductase activity
Tcur_2379	COG0714	Associated with various cellular activities
Tcur_2382	COG0671	phosphoesterase, PA-phosphatase related
Tcur_2383	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Tcur_2384	COG4974	Belongs to the 'phage' integrase family
Tcur_2389	COG4974	Belongs to the 'phage' integrase family
Tcur_2391	COG2313	pseudouridylate synthase activity
Tcur_2396	COG1649	PFAM Uncharacterised BCR, COG1649
Tcur_2398	COG1169	isochorismate synthase
Tcur_2402	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Tcur_2403	COG4948	Mandelate Racemase Muconate Lactonizing
Tcur_2406	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tcur_2412	COG2146	nitrite reductase [NAD(P)H] activity
Tcur_2412	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tcur_2413	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Tcur_2414	COG0243	molybdopterin cofactor binding
Tcur_2417	COG2223	nitrite transmembrane transporter activity
Tcur_2422	COG3226	Transcriptional regulator
Tcur_2423	COG1556	Lactate utilization protein
Tcur_2425	COG0247	lactate metabolic process
Tcur_2429	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tcur_2429	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tcur_2437	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tcur_2439	COG0494	nUDIX hydrolase
Tcur_2440	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tcur_2442	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
Tcur_2443	COG1522	sequence-specific DNA binding
Tcur_2447	COG0753	catalase activity
Tcur_2448	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tcur_2451	COG2264	protein methyltransferase activity
Tcur_2456	COG1414	Transcriptional regulator
Tcur_2460	COG0438	transferase activity, transferring glycosyl groups
Tcur_2461	COG1309	transcriptional regulator
Tcur_2465	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Tcur_2468	COG4585	Histidine kinase
Tcur_2469	COG2197	response regulator
Tcur_2474	COG0243	molybdopterin cofactor binding
Tcur_2484	COG0754	glutathionylspermidine amidase activity
Tcur_2487	COG1960	acyl-CoA dehydrogenase activity
Tcur_2488	COG0463	Glycosyl transferase, family 2
Tcur_2493	COG4555	ABC transporter
Tcur_2495	COG1280	lysine exporter protein (LysE YggA)
Tcur_2496	COG2076	Multidrug Resistance protein
Tcur_2499	COG1960	acyl-CoA dehydrogenase activity
Tcur_2508	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Tcur_2509	COG0657	acetylesterase activity
Tcur_2510	COG1960	acyl-CoA dehydrogenase activity
Tcur_2526	COG1819	glycosyl
Tcur_2545	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tcur_2553	COG3903	Transcriptional regulator
Tcur_2553	COG3629	intracellular signal transduction
Tcur_2554	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Tcur_2561	COG1070	Carbohydrate kinase
Tcur_2563	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tcur_2563	COG0515	serine threonine protein kinase
Tcur_2566	COG0574	Belongs to the PEP-utilizing enzyme family
Tcur_2566	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tcur_2571	COG0583	DNA-binding transcription factor activity
Tcur_2572	COG0477	Major facilitator Superfamily
Tcur_2583	COG2124	cytochrome p450
Tcur_2587	COG1024	Enoyl-CoA hydratase
Tcur_2591	COG2186	Transcriptional regulator
Tcur_2592	COG1946	Acyl-CoA thioesterase
Tcur_2597	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tcur_2598	COG3002	Belongs to the UPF0753 family
Tcur_2599	COG0659	secondary active sulfate transmembrane transporter activity
Tcur_2603	COG1960	acyl-CoA dehydrogenase activity
Tcur_2616	COG0583	DNA-binding transcription factor activity
Tcur_2629	COG1316	TRANSCRIPTIONal
Tcur_2633	COG4948	Mandelate Racemase Muconate Lactonizing
Tcur_2638	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tcur_2640	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Tcur_2643	COG2770	Histidine kinase
Tcur_2643	COG2208	phosphoserine phosphatase activity
Tcur_2644	COG0784	Response regulator, receiver
Tcur_2644	COG5002	protein histidine kinase activity
Tcur_2645	COG3706	GGDEF domain
Tcur_2645	COG0745	RESPONSE REGULATOR receiver
Tcur_2647	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tcur_2650	COG2183	response to ionizing radiation
Tcur_2654	COG3486	L-lysine 6-monooxygenase (NADPH) activity
Tcur_2656	COG0701	Predicted permease
Tcur_2667	COG1643	Atp-dependent helicase
Tcur_2669	COG0667	Aldo Keto reductase
Tcur_2670	COG1940	carbohydrate kinase activity
Tcur_2672	COG4214	carbohydrate transport
Tcur_2674	COG4213	ABC transporter substrate-binding protein
Tcur_2685	COG1518	maintenance of DNA repeat elements
Tcur_2692	COG0300	oxidoreductase activity
Tcur_2695	COG1309	transcriptional regulator
Tcur_2697	COG1024	Enoyl-CoA hydratase
Tcur_2699	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_2700	COG1024	Enoyl-CoA hydratase
Tcur_2702	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_2703	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_2706	COG1960	acyl-CoA dehydrogenase activity
Tcur_2707	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_2710	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_2712	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_2713	COG0183	Belongs to the thiolase family
Tcur_2716	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tcur_2717	COG0601	transmembrane transport
Tcur_2718	COG4172	Belongs to the ABC transporter superfamily
Tcur_2719	COG4166	transmembrane transport
Tcur_2720	COG1024	Enoyl-CoA hydratase
Tcur_2722	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tcur_2727	COG0667	Aldo Keto reductase
Tcur_2733	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Tcur_2747	COG0438	transferase activity, transferring glycosyl groups
Tcur_2757	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_2761	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tcur_2769	COG4585	Histidine kinase
Tcur_2770	COG2197	response regulator
Tcur_2771	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tcur_2772	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tcur_2779	COG1960	acyl-CoA dehydrogenase activity
Tcur_2784	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Tcur_2791	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Tcur_2797	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Tcur_2816	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Tcur_2819	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Tcur_2822	COG0725	ABC transporter, periplasmic molybdate-binding protein
Tcur_2826	COG1160	GTP binding
Tcur_2827	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tcur_2829	COG4401	Chorismate mutase type I
Tcur_2831	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tcur_2836	COG0504	CTP synthase activity
Tcur_2841	COG2070	2-Nitropropane dioxygenase
Tcur_2845	COG0556	nucleotide-excision repair
Tcur_2846	COG4585	Histidine kinase
Tcur_2847	COG0237	dephospho-CoA kinase activity
Tcur_2851	COG0726	polysaccharide deacetylase
Tcur_2853	COG2050	protein possibly involved in aromatic compounds catabolism
Tcur_2856	COG0411	ABC transporter
Tcur_2863	COG0693	protein deglycase activity
Tcur_2866	COG0070	glutamate synthase
Tcur_2866	COG0069	glutamate synthase activity
Tcur_2866	COG0067	glutamate synthase
Tcur_2870	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tcur_2873	COG0159	tryptophan synthase activity
Tcur_2874	COG0133	tryptophan synthase activity
Tcur_2875	COG0134	indole-3-glycerol-phosphate synthase activity
Tcur_2877	COG0745	RESPONSE REGULATOR receiver
Tcur_2879	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Tcur_2881	COG1132	(ABC) transporter
Tcur_2882	COG1132	(ABC) transporter
Tcur_2886	COG1960	acyl-CoA dehydrogenase activity
Tcur_2890	COG0107	imidazoleglycerol-phosphate synthase activity
Tcur_2891	COG0251	oxidation-reduction process
Tcur_2892	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Tcur_2893	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Tcur_2895	COG0131	Imidazoleglycerol-phosphate dehydratase
Tcur_2896	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tcur_2897	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Tcur_2898	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tcur_2899	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Tcur_2901	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Tcur_2903	COG0587	DNA-directed DNA polymerase activity
Tcur_2906	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tcur_2912	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tcur_2915	COG1872	DUF167
Tcur_2916	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tcur_2921	COG1799	cell septum assembly
Tcur_2923	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tcur_2924	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Tcur_2925	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tcur_2926	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tcur_2928	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tcur_2929	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tcur_2931	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tcur_2932	COG0768	penicillin binding
Tcur_2934	COG0275	rRNA processing
Tcur_2935	COG2001	Belongs to the MraZ family
Tcur_2936	COG0714	Associated with various cellular activities
Tcur_2942	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tcur_2943	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tcur_2944	COG0006	proline dipeptidase activity
Tcur_2945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_2946	COG1024	Enoyl-CoA hydratase
Tcur_2946	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tcur_2950	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Tcur_2951	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Tcur_2952	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tcur_2953	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Tcur_2957	COG2197	response regulator
Tcur_2958	COG4585	Histidine kinase
Tcur_2960	COG1131	(ABC) transporter
Tcur_2961	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tcur_2966	COG0542	response to heat
Tcur_2968	COG2233	PERMEase
Tcur_2971	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tcur_2972	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Tcur_2973	COG2017	converts alpha-aldose to the beta-anomer
Tcur_2975	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tcur_2975	COG3608	succinylglutamate desuccinylase aspartoacylase
Tcur_2978	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Tcur_2978	COG3608	succinylglutamate desuccinylase aspartoacylase
Tcur_2980	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tcur_2988	COG0154	amidase activity
Tcur_2993	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Tcur_2994	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tcur_2995	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tcur_2995	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tcur_2997	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tcur_2998	COG0671	phosphoesterase, PA-phosphatase related
Tcur_3000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tcur_3001	COG0242	peptide deformylase activity
Tcur_3003	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tcur_3004	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tcur_3006	COG1758	RNA polymerase activity
Tcur_3007	COG0194	GDP metabolic process
Tcur_3009	COG0284	orotidine-5'-phosphate decarboxylase activity
Tcur_3010	COG0167	dihydroorotate dehydrogenase activity
Tcur_3011	COG0543	2 iron, 2 sulfur cluster binding
Tcur_3012	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tcur_3013	COG0505	Belongs to the CarA family
Tcur_3014	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tcur_3015	COG0540	Belongs to the ATCase OTCase family
Tcur_3016	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tcur_3018	COG2814	Major facilitator Superfamily
Tcur_3021	COG0442	prolyl-tRNA aminoacylation
Tcur_3025	COG0456	acetyltransferase
Tcur_3027	COG0142	geranyltranstransferase activity
Tcur_3030	COG0352	thiamine-phosphate diphosphorylase activity
Tcur_3035	COG2022	thiamine diphosphate biosynthetic process
Tcur_3036	COG0515	serine threonine protein kinase
Tcur_3036	COG2815	serine threonine protein kinase
Tcur_3037	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tcur_3038	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Tcur_3039	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Tcur_3040	COG0697	spore germination
Tcur_3042	COG0301	tRNA thio-modification
Tcur_3043	COG0205	6-phosphofructokinase activity
Tcur_3047	COG1940	carbohydrate kinase activity
Tcur_3059	COG0438	transferase activity, transferring glycosyl groups
Tcur_3060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Tcur_3061	COG0723	plastoquinol--plastocyanin reductase activity
Tcur_3062	COG2010	Cytochrome c
Tcur_3063	COG1845	cytochrome c oxidase, subunit III
Tcur_3065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Tcur_3074	COG0501	Belongs to the peptidase M48B family
Tcur_3077	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Tcur_3078	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Tcur_3083	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tcur_3087	COG0667	Aldo Keto reductase
Tcur_3090	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tcur_3091	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Tcur_3092	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tcur_3095	COG3340	Belongs to the peptidase S51 family
Tcur_3096	COG0321	lipoyl(octanoyl) transferase activity
Tcur_3098	COG0393	Putative heavy-metal-binding
Tcur_3099	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Tcur_3101	COG1714	RDD family
Tcur_3103	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tcur_3105	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Tcur_3106	COG0174	glutamine synthetase
Tcur_3108	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tcur_3108	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tcur_3112	COG0477	Major facilitator Superfamily
Tcur_3113	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tcur_3116	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Tcur_3121	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tcur_3122	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_3124	COG3336	cytochrome c oxidase
Tcur_3128	COG2351	hydroxyisourate hydrolase activity
Tcur_3129	COG2252	PERMEase
Tcur_3130	COG1929	Belongs to the glycerate kinase type-1 family
Tcur_3132	COG0406	alpha-ribazole phosphatase activity
Tcur_3133	COG1937	Protein conserved in bacteria
Tcur_3136	COG0405	Gamma-glutamyltransferase
Tcur_3137	COG0531	amino acid
Tcur_3144	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tcur_3147	COG1881	PFAM PEBP family protein
Tcur_3153	COG2319	Wd-40 repeat
Tcur_3153	COG5635	Nacht domain
Tcur_3159	COG0477	Major facilitator Superfamily
Tcur_3164	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tcur_3167	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tcur_3170	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Tcur_3172	COG3279	Response regulator of the LytR AlgR family
Tcur_3173	COG3275	phosphorelay sensor kinase activity
Tcur_3176	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tcur_3180	COG1011	Hydrolase
Tcur_3187	COG1358	cellular component organization or biogenesis
Tcur_3197	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tcur_3198	COG0358	DNA primase activity
Tcur_3202	COG0831	urea catabolic process
Tcur_3203	COG0832	Belongs to the urease beta subunit family
Tcur_3204	COG0804	urea catabolic process
Tcur_3206	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Tcur_3207	COG0829	nickel cation binding
Tcur_3210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tcur_3211	COG1595	DNA-templated transcription, initiation
Tcur_3215	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Tcur_3217	COG0574	Belongs to the PEP-utilizing enzyme family
Tcur_3217	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tcur_3218	COG3387	PFAM Glycoside hydrolase 15-related
Tcur_3221	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tcur_3221	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tcur_3224	COG0423	glycine-tRNA ligase activity
Tcur_3228	COG1121	(ABC) transporter
Tcur_3229	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tcur_3231	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tcur_3232	COG1381	Involved in DNA repair and RecF pathway recombination
Tcur_3235	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tcur_3236	COG0410	ABC transporter
Tcur_3241	COG1834	amidinotransferase
Tcur_3243	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tcur_3246	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tcur_3248	COG0537	adenosine 5'-monophosphoramidase activity
Tcur_3252	COG0484	heat shock protein binding
Tcur_3253	COG1420	regulation of RNA biosynthetic process
Tcur_3261	COG0481	GTPase activity
Tcur_3262	COG0268	Binds directly to 16S ribosomal RNA
Tcur_3267	COG1596	polysaccharide export
Tcur_3267	COG1555	photosystem II stabilization
Tcur_3268	COG1228	amidohydrolase
Tcur_3269	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tcur_3271	COG0277	FAD linked oxidase domain protein
Tcur_3272	COG0277	FAD linked oxidase domain protein
Tcur_3273	COG0247	lactate metabolic process
Tcur_3281	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tcur_3282	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tcur_3285	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tcur_3286	COG1126	abc transporter atp-binding protein
Tcur_3287	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tcur_3288	COG0765	amino acid transport
Tcur_3289	COG0765	amino acid transport
Tcur_3291	COG1418	mRNA catabolic process
Tcur_3294	COG1372	Participates in initiation and elongation during chromosome replication
Tcur_3294	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tcur_3301	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tcur_3302	COG0783	Belongs to the Dps family
Tcur_3303	COG1396	sequence-specific DNA binding
Tcur_3304	COG1058	Belongs to the CinA family
Tcur_3304	COG1546	Belongs to the CinA family
Tcur_3306	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tcur_3308	COG1674	ftsk spoiiie
Tcur_3309	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Tcur_3310	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tcur_3316	COG0477	Major facilitator Superfamily
Tcur_3318	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Tcur_3321	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tcur_3322	COG1950	PFAM Membrane protein of
Tcur_3323	COG0612	Peptidase, M16
Tcur_3324	COG1185	polyribonucleotide nucleotidyltransferase activity
Tcur_3325	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tcur_3327	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tcur_3328	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tcur_3329	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tcur_3331	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tcur_3333	COG0779	Required for maturation of 30S ribosomal subunits
Tcur_3342	COG1960	acyl-CoA dehydrogenase activity
Tcur_3345	COG3485	protocatechuate 3,4-dioxygenase
Tcur_3346	COG3485	protocatechuate 3,4-dioxygenase
Tcur_3347	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tcur_3352	COG1309	transcriptional regulator
Tcur_3356	COG1515	deoxyribonuclease V activity
Tcur_3365	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Tcur_3370	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tcur_3372	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tcur_3374	COG2153	protein acetylation
Tcur_3377	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Tcur_3380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tcur_3381	COG2154	pterin-4-alpha-carbinolamine dehydratase
Tcur_3384	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tcur_3390	COG2124	cytochrome p450
Tcur_3392	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tcur_3393	COG1177	transmembrane transport
Tcur_3394	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tcur_3396	COG3842	ATPase activity
Tcur_3398	COG1522	sequence-specific DNA binding
Tcur_3400	COG1121	(ABC) transporter
Tcur_3404	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tcur_3407	COG0233	cytoplasmic translational termination
Tcur_3408	COG0528	UMP kinase activity
Tcur_3409	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tcur_3410	COG0052	Belongs to the universal ribosomal protein uS2 family
Tcur_3413	COG0792	nuclease activity
Tcur_3414	COG0606	chelatase, subunit chli
Tcur_3417	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tcur_3418	COG0681	Belongs to the peptidase S26 family
Tcur_3419	COG0335	large ribosomal subunit rRNA binding
Tcur_3420	COG0336	Belongs to the RNA methyltransferase TrmD family
Tcur_3421	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tcur_3422	COG1837	Belongs to the UPF0109 family
Tcur_3425	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Tcur_3429	COG1196	nuclear chromosome segregation
Tcur_3431	COG1254	Belongs to the acylphosphatase family
Tcur_3432	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Tcur_3433	COG0571	ribonuclease III activity
Tcur_3434	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tcur_3436	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tcur_3437	COG0742	ribosomal rna small subunit methyltransferase
Tcur_3439	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tcur_3441	COG0351	phosphomethylpyrimidine kinase
Tcur_3447	COG0667	Aldo Keto reductase
Tcur_3449	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Tcur_3449	COG1017	nitric oxide dioxygenase activity
Tcur_3450	COG1959	2 iron, 2 sulfur cluster binding
Tcur_3452	COG1309	transcriptional regulator
Tcur_3453	COG1024	Enoyl-CoA hydratase
Tcur_3456	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tcur_3460	COG0776	regulation of translation
Tcur_3462	COG0066	3-isopropylmalate dehydratase activity
Tcur_3463	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Tcur_3464	COG1414	Transcriptional regulator
Tcur_3471	COG4569	acetaldehyde dehydrogenase (acetylating) activity
Tcur_3473	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3474	COG0183	Belongs to the thiolase family
Tcur_3475	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_3481	COG1960	acyl-CoA dehydrogenase activity
Tcur_3483	COG1960	acyl-CoA dehydrogenase activity
Tcur_3484	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_3485	COG1902	pentaerythritol trinitrate reductase activity
Tcur_3485	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tcur_3489	COG0559	Belongs to the binding-protein-dependent transport system permease family
Tcur_3491	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3494	COG1960	acyl-CoA dehydrogenase activity
Tcur_3495	COG0183	Belongs to the thiolase family
Tcur_3497	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3500	COG1309	transcriptional regulator
Tcur_3508	COG1960	acyl-CoA dehydrogenase activity
Tcur_3512	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_3515	COG1053	succinate dehydrogenase
Tcur_3518	COG0667	Aldo Keto reductase
Tcur_3521	COG1053	succinate dehydrogenase
Tcur_3522	COG2267	carboxylic ester hydrolase activity
Tcur_3523	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tcur_3525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Tcur_3529	COG2409	Drug exporters of the RND superfamily
Tcur_3534	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Tcur_3537	COG0579	oxidoreductase
Tcur_3538	COG0179	Fumarylacetoacetate (FAA) hydrolase
Tcur_3542	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Tcur_3543	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tcur_3544	COG0473	3-isopropylmalate dehydrogenase activity
Tcur_3550	COG1136	(ABC) transporter
Tcur_3550	COG4591	ABC-type transport system involved in lipoprotein release permease component
Tcur_3552	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tcur_3555	COG5001	Diguanylate cyclase
Tcur_3557	COG2133	pyrroloquinoline quinone binding
Tcur_3558	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tcur_3559	COG0154	amidase activity
Tcur_3560	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tcur_3563	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tcur_3564	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
Tcur_3567	COG0482	sulfurtransferase activity
Tcur_3570	COG1309	transcriptional regulator
Tcur_3573	COG0714	Associated with various cellular activities
Tcur_3574	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tcur_3577	COG0515	serine threonine protein kinase
Tcur_3577	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tcur_3579	COG0300	oxidoreductase activity
Tcur_3580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Tcur_3581	COG4279	zinc finger
Tcur_3582	COG0058	SHG alpha-glucan phosphorylase activity
Tcur_3583	COG0366	Alpha amylase catalytic
Tcur_3585	COG3281	Trehalose synthase
Tcur_3598	COG2186	Transcriptional regulator
Tcur_3603	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tcur_3608	COG0616	signal peptide processing
Tcur_3609	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Tcur_3610	COG0515	serine threonine protein kinase
Tcur_3612	COG1132	(ABC) transporter
Tcur_3613	COG1132	(ABC) transporter
Tcur_3614	COG2197	response regulator
Tcur_3615	COG1228	amidohydrolase
Tcur_3617	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tcur_3618	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Tcur_3619	COG2986	histidine ammonia-lyase
Tcur_3621	COG1414	Transcriptional regulator
Tcur_3625	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tcur_3634	COG1174	glycine betaine transport
Tcur_3635	COG1174	glycine betaine transport
Tcur_3636	COG0517	IMP dehydrogenase activity
Tcur_3636	COG1125	glycine betaine transport
Tcur_3637	COG1609	Transcriptional regulator
Tcur_3638	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
Tcur_3639	COG0121	glutamine amidotransferase
Tcur_3640	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tcur_3643	COG1960	acyl-CoA dehydrogenase activity
Tcur_3644	COG1960	acyl-CoA dehydrogenase activity
Tcur_3645	COG1309	transcriptional regulator
Tcur_3646	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3650	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tcur_3651	COG2124	cytochrome p450
Tcur_3654	COG0183	Belongs to the thiolase family
Tcur_3655	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tcur_3658	COG0438	transferase activity, transferring glycosyl groups
Tcur_3659	COG2226	methyltransferase
Tcur_3671	COG1024	Enoyl-CoA hydratase
Tcur_3672	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3675	COG0508	dehydrogenase complex catalyzes the overall conversion of
Tcur_3675	COG0567	Dehydrogenase, E1 component
Tcur_3678	COG1695	Transcriptional regulator
Tcur_3680	COG0604	alcohol dehydrogenase
Tcur_3682	COG0765	amino acid transport
Tcur_3683	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tcur_3690	COG2172	sigma factor antagonist activity
Tcur_3693	COG1597	lipid kinase activity
Tcur_3697	COG2188	Transcriptional regulator
Tcur_3698	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tcur_3699	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Tcur_3702	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Tcur_3703	COG0439	Biotin carboxylase
Tcur_3705	COG2199	diguanylate cyclase activity
Tcur_3705	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tcur_3707	COG5662	AntiSigma factor
Tcur_3708	COG1595	DNA-templated transcription, initiation
Tcur_3709	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tcur_3711	COG2135	peptidase activity
Tcur_3714	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Tcur_3718	COG0483	inositol monophosphate 1-phosphatase activity
Tcur_3722	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3724	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_3727	COG3480	Lon protease (S16) C-terminal proteolytic domain
Tcur_3730	COG1615	UPF0182 protein
Tcur_3738	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Tcur_3742	COG1946	Acyl-CoA thioesterase
Tcur_3748	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Tcur_3750	COG4264	IucA IucC family
Tcur_3752	COG2226	methyltransferase
Tcur_3753	COG0210	DNA helicase
Tcur_3756	COG1404	Belongs to the peptidase S8 family
Tcur_3767	COG2409	Drug exporters of the RND superfamily
Tcur_3775	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tcur_3796	COG2076	Multidrug Resistance protein
Tcur_3807	COG2124	cytochrome p450
Tcur_3809	COG2018	Roadblock/LC7 domain
Tcur_3812	COG0589	response to stress
Tcur_3814	COG1834	amidinotransferase
Tcur_3819	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Tcur_3829	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tcur_3830	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tcur_3833	COG1309	transcriptional regulator
Tcur_3834	COG1309	transcriptional regulator
Tcur_3842	COG0750	zinc metalloprotease
Tcur_3845	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tcur_3846	COG0509	glycine decarboxylation via glycine cleavage system
Tcur_3847	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tcur_3857	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tcur_3858	COG1486	melibiose metabolic process
Tcur_3864	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tcur_3865	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Tcur_3867	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tcur_3875	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Tcur_3877	COG1335	isochorismatase
Tcur_3878	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tcur_3882	COG1678	Uncharacterized ACR, COG1678
Tcur_3885	COG1102	Psort location Cytoplasmic, score
Tcur_3885	COG1904	glucuronate isomerase
Tcur_3887	COG1131	(ABC) transporter
Tcur_3890	COG0183	Belongs to the thiolase family
Tcur_3896	COG0596	Alpha beta hydrolase
Tcur_3900	COG1250	3-hydroxyacyl-CoA dehydrogenase
Tcur_3903	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
Tcur_3906	COG1994	Peptidase M50
Tcur_3908	COG1012	belongs to the aldehyde dehydrogenase family
Tcur_3915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tcur_3916	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tcur_3917	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tcur_3918	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tcur_3919	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tcur_3920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tcur_3921	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tcur_3930	COG2890	protein-(glutamine-N5) methyltransferase activity
Tcur_3931	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tcur_3932	COG0254	rRNA binding
Tcur_3933	COG2197	response regulator
Tcur_3936	COG0083	homoserine kinase activity
Tcur_3938	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tcur_3939	COG0460	homoserine dehydrogenase
Tcur_3940	COG0019	diaminopimelate decarboxylase activity
Tcur_3943	COG0582	viral genome integration into host DNA
Tcur_3951	COG1902	pentaerythritol trinitrate reductase activity
Tcur_3951	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tcur_3953	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3956	COG0018	arginyl-trna synthetase
Tcur_3960	COG1686	Belongs to the peptidase S11 family
Tcur_3965	COG1309	transcriptional regulator
Tcur_3966	COG0028	Belongs to the TPP enzyme family
Tcur_3967	COG0515	serine threonine protein kinase
Tcur_3967	COG2815	serine threonine protein kinase
Tcur_3969	COG0515	serine threonine protein kinase
Tcur_3969	COG2815	serine threonine protein kinase
Tcur_3970	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Tcur_3970	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tcur_3978	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_3979	COG1846	Transcriptional regulator
Tcur_3980	COG0318	PFAM AMP-dependent synthetase and ligase
Tcur_3987	COG2070	2-Nitropropane dioxygenase
Tcur_3989	COG0500	methyltransferase
Tcur_3992	COG4981	capsule polysaccharide biosynthetic process
Tcur_3994	COG1215	transferase activity, transferring glycosyl groups
Tcur_3998	COG1960	acyl-CoA dehydrogenase activity
Tcur_4003	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tcur_4004	COG0793	Belongs to the peptidase S41A family
Tcur_4004	COG3409	Peptidoglycan-binding domain 1 protein
Tcur_4006	COG2884	Cell division ATP-binding protein ftsE
Tcur_4009	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tcur_4011	COG2902	Dehydrogenase
Tcur_4013	COG0741	lytic transglycosylase activity
Tcur_4013	COG0791	NLP P60 protein
Tcur_4014	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tcur_4016	COG1012	belongs to the aldehyde dehydrogenase family
Tcur_4019	COG1011	Hydrolase
Tcur_4021	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Tcur_4022	COG1737	Transcriptional regulator
Tcur_4025	COG1472	Belongs to the glycosyl hydrolase 3 family
Tcur_4026	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tcur_4027	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Tcur_4029	COG1263	PTS System
Tcur_4029	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tcur_4030	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tcur_4031	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tcur_4033	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Tcur_4033	COG1263	PTS System
Tcur_4033	COG2190	(PTS) system
Tcur_4035	COG0653	protein targeting
Tcur_4037	COG3214	Protein conserved in bacteria
Tcur_4039	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tcur_4040	COG1040	competence protein
Tcur_4041	COG5401	PFAM Sporulation and spore germination
Tcur_4042	COG5000	phosphorelay sensor kinase activity
Tcur_4042	COG5002	protein histidine kinase activity
Tcur_4043	COG0745	RESPONSE REGULATOR receiver
Tcur_4048	COG0714	Associated with various cellular activities
Tcur_4055	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tcur_4056	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tcur_4061	COG2222	sugar isomerase
Tcur_4062	COG2835	tetraacyldisaccharide 4'-kinase activity
Tcur_4073	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
Tcur_4073	COG0778	Nitroreductase
Tcur_4075	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Tcur_4076	COG0583	DNA-binding transcription factor activity
Tcur_4080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Tcur_4082	COG2226	methyltransferase
Tcur_4084	COG3118	belongs to the thioredoxin family
Tcur_4092	COG0438	transferase activity, transferring glycosyl groups
Tcur_4096	COG1316	TRANSCRIPTIONal
Tcur_4097	COG3594	Acyltransferase
Tcur_4098	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Tcur_4104	COG3973	AAA domain
Tcur_4108	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tcur_4111	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tcur_4114	COG1316	TRANSCRIPTIONal
Tcur_4117	COG1832	CoA-binding protein
Tcur_4121	COG2205	protein histidine kinase activity
Tcur_4122	COG0745	RESPONSE REGULATOR receiver
Tcur_4125	COG2193	ferroxidase activity
Tcur_4126	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Tcur_4129	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Tcur_4130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Tcur_4132	COG1432	Conserved Protein
Tcur_4147	COG1674	ftsk spoiiie
Tcur_4155	COG0640	Transcriptional regulator
Tcur_4160	COG2197	response regulator
Tcur_4163	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Tcur_4165	COG2346	COG2346, Truncated hemoglobins
Tcur_4175	COG4770	biotin carboxylase activity
Tcur_4183	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tcur_4185	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Tcur_4195	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_4199	COG1473	amidohydrolase
Tcur_4199	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tcur_4200	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Tcur_4201	COG1686	Belongs to the peptidase S11 family
Tcur_4204	COG0180	Tryptophanyl-tRNA synthetase
Tcur_4206	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tcur_4209	COG0039	L-malate dehydrogenase activity
Tcur_4213	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tcur_4215	COG0138	bifunctional purine biosynthesis protein purh
Tcur_4221	COG0045	succinate-CoA ligase (ADP-forming) activity
Tcur_4226	COG2197	response regulator
Tcur_4238	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Tcur_4240	COG0438	transferase activity, transferring glycosyl groups
Tcur_4243	COG0450	alkyl hydroperoxide reductase
Tcur_4244	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Tcur_4247	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tcur_4247	COG0519	Catalyzes the synthesis of GMP from XMP
Tcur_4249	COG1012	belongs to the aldehyde dehydrogenase family
Tcur_4251	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Tcur_4252	COG0516	GMP reductase activity
Tcur_4256	COG1595	DNA-templated transcription, initiation
Tcur_4257	COG0459	protein refolding
Tcur_4258	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tcur_4261	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tcur_4262	COG0456	acetyltransferase
Tcur_4263	COG0456	acetyltransferase
Tcur_4263	COG1214	PFAM Peptidase M22, glycoprotease
Tcur_4265	COG0802	atpase or kinase
Tcur_4267	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tcur_4269	COG0736	holo-[acyl-carrier-protein] synthase activity
Tcur_4273	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tcur_4274	COG1072	(Pantothenic acid kinase))
Tcur_4278	COG1131	(ABC) transporter
Tcur_4282	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tcur_4283	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tcur_4284	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tcur_4285	COG2340	Cysteine-rich secretory protein family
Tcur_4288	COG0101	tRNA pseudouridine synthase activity
Tcur_4289	COG0203	ribosomal protein L17
Tcur_4290	COG0202	RNA polymerase activity
Tcur_4291	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tcur_4292	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tcur_4293	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tcur_4294	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tcur_4295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tcur_4297	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Tcur_4300	COG0563	adenylate kinase activity
Tcur_4302	COG0200	Binds to the 23S rRNA
Tcur_4303	COG1841	ribosomal large subunit assembly
Tcur_4304	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tcur_4305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tcur_4306	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tcur_4307	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tcur_4308	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tcur_4309	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tcur_4310	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tcur_4311	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tcur_4312	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tcur_4313	COG0255	Belongs to the universal ribosomal protein uL29 family
Tcur_4314	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tcur_4315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tcur_4316	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tcur_4317	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tcur_4318	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tcur_4319	COG0089	rRNA binding
Tcur_4320	COG0088	Forms part of the polypeptide exit tunnel
Tcur_4321	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tcur_4322	COG0051	transcription antitermination factor activity, RNA binding
Tcur_4323	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tcur_4324	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tcur_4325	COG0049	tRNA binding
Tcur_4326	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tcur_4329	COG0577	efflux transmembrane transporter activity
Tcur_4329	COG1136	(ABC) transporter
Tcur_4330	COG1136	(ABC) transporter
Tcur_4330	COG0577	efflux transmembrane transporter activity
Tcur_4337	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tcur_4338	COG0085	RNA polymerase activity
Tcur_4342	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Tcur_4347	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tcur_4348	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Tcur_4349	COG1127	ABC transporter
Tcur_4350	COG0222	ribosome binding
Tcur_4351	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tcur_4354	COG0081	regulation of translation
Tcur_4355	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tcur_4357	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tcur_4358	COG0436	Aminotransferase
Tcur_4359	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Tcur_4361	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tcur_4363	COG2030	dehydratase
Tcur_4364	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tcur_4367	COG1960	acyl-CoA dehydrogenase activity
Tcur_4374	COG1666	GTP binding
Tcur_4376	COG0024	Methionine aminopeptidase
Tcur_4377	COG0501	Belongs to the peptidase M48B family
Tcur_4378	COG1007	ATP synthesis coupled electron transport
Tcur_4381	COG0713	ATP synthesis coupled electron transport
Tcur_4383	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tcur_4386	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tcur_4387	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tcur_4388	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tcur_4391	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tcur_4391	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tcur_4392	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tcur_4393	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tcur_4396	COG0477	Major facilitator Superfamily
Tcur_4398	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tcur_4402	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Tcur_4407	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tcur_4408	COG0713	ATP synthesis coupled electron transport
Tcur_4410	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tcur_4411	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Tcur_4412	COG1034	ATP synthesis coupled electron transport
Tcur_4415	COG0649	NAD binding
Tcur_4416	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tcur_4417	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tcur_4421	COG2226	methyltransferase
Tcur_4428	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Tcur_4429	COG1333	cytochrome c biogenesis protein
Tcur_4430	COG0785	Cytochrome C biogenesis protein
Tcur_4431	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Tcur_4432	COG0406	alpha-ribazole phosphatase activity
Tcur_4434	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tcur_4435	COG0515	serine threonine protein kinase
Tcur_4437	COG0113	porphobilinogen synthase activity
Tcur_4439	COG0181	hydroxymethylbilane synthase activity
Tcur_4440	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tcur_4441	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tcur_4446	COG0560	Phosphoserine phosphatase
Tcur_4452	COG0123	including yeast histone deacetylase and acetoin utilization protein
Tcur_4455	COG0577	efflux transmembrane transporter activity
Tcur_4455	COG1136	(ABC) transporter
Tcur_4456	COG1136	(ABC) transporter
Tcur_4459	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Tcur_4460	COG0506	proline dehydrogenase activity
Tcur_4461	COG1316	TRANSCRIPTIONal
Tcur_4463	COG1309	transcriptional regulator
Tcur_4464	COG1082	Xylose isomerase domain protein TIM barrel
Tcur_4465	COG0500	methyltransferase
Tcur_4466	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tcur_4467	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Tcur_4475	COG0542	response to heat
Tcur_4479	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Tcur_4482	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tcur_4483	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tcur_4484	COG0157	Belongs to the NadC ModD family
Tcur_4485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Tcur_4486	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tcur_4487	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tcur_4488	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Tcur_4490	COG1136	(ABC) transporter
Tcur_4491	COG2197	response regulator
Tcur_4492	COG4585	Histidine kinase
Tcur_4497	COG0649	NAD binding
Tcur_4500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tcur_4501	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Tcur_4504	COG0302	gtp cyclohydrolase
Tcur_4507	COG0037	tRNA processing
Tcur_4509	COG2027	D-alanyl-D-alanine carboxypeptidase
Tcur_4510	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Tcur_4511	COG0791	NLP P60 protein
Tcur_4511	COG3883	PFAM NLP P60 protein
Tcur_4520	COG2186	Transcriptional regulator
Tcur_4522	COG0454	-acetyltransferase
Tcur_4536	COG0582	viral genome integration into host DNA
Tcur_4539	COG1774	PSP1 C-terminal conserved region
Tcur_4542	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Tcur_4543	COG0470	DNA polymerase III
Tcur_4544	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tcur_4545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tcur_4545	COG1754	DNA topoisomerase type I activity
Tcur_4547	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tcur_4550	COG0596	Alpha beta hydrolase
Tcur_4551	COG2197	response regulator
Tcur_4581	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tcur_4583	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Tcur_4584	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Tcur_4587	COG0309	Hydrogenase expression formation protein (HypE)
Tcur_4588	COG0409	Hydrogenase expression formation protein
Tcur_4589	COG0298	carbon dioxide binding
Tcur_4594	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Tcur_4596	COG0375	protein maturation
Tcur_4602	COG3559	Exporter of polyketide antibiotics
Tcur_4603	COG1131	(ABC) transporter
Tcur_4611	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tcur_4612	COG1960	acyl-CoA dehydrogenase activity
Tcur_4613	COG1960	acyl-CoA dehydrogenase activity
Tcur_4614	COG1024	Enoyl-CoA hydratase
Tcur_4615	COG1028	Short-chain dehydrogenase reductase Sdr
Tcur_4616	COG0183	Belongs to the thiolase family
Tcur_4617	COG2186	Transcriptional regulator
Tcur_4618	COG1024	Enoyl-CoA hydratase
Tcur_4625	COG1320	monovalent cation:proton antiporter activity
Tcur_4626	COG2212	antiporter activity
Tcur_4627	COG1863	multisubunit Na H antiporter MnhE subunit
Tcur_4630	COG2111	Na H antiporter
Tcur_4630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tcur_4636	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Tcur_4637	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Tcur_4661	COG2197	response regulator
Tcur_4665	COG1253	flavin adenine dinucleotide binding
Tcur_4670	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tcur_4671	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Tcur_4682	COG4566	intracellular signal transduction
Tcur_4689	COG2255	four-way junction helicase activity
Tcur_4702	COG3260	NADH ubiquinone oxidoreductase 20
Tcur_4704	COG0650	Formate hydrogenlyase subunit 4
Tcur_4706	COG0651	ATP synthesis coupled electron transport
Tcur_4707	COG3261	NADH dehydrogenase
Tcur_4707	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Tcur_4709	COG0515	serine threonine protein kinase
Tcur_4712	COG4608	Belongs to the ABC transporter superfamily
Tcur_4713	COG0444	Belongs to the ABC transporter superfamily
Tcur_4715	COG0601	transmembrane transport
Tcur_4718	COG1742	UPF0060 membrane protein
Tcur_4719	COG0310	cobalt ion transport
Tcur_4720	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
Tcur_4722	COG1122	ATPase activity
Tcur_4729	COG2197	response regulator
Tcur_4733	COG1024	Enoyl-CoA hydratase
Tcur_4735	COG0789	Transcriptional regulator
Tcur_4736	COG2814	Major facilitator Superfamily
Tcur_4737	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Tcur_4739	COG1294	oxidase, subunit
Tcur_4740	COG1271	oxidase subunit
Tcur_4749	COG1595	DNA-templated transcription, initiation
Tcur_4750	COG0596	Alpha beta hydrolase
Tcur_4750	COG2226	methyltransferase
Tcur_4750	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Tcur_4752	COG0642	Histidine kinase
Tcur_4758	COG1819	glycosyl
Tcur_4763	COG3339	Conserved Protein
Tcur_4765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Tcur_4772	COG1309	transcriptional regulator
Tcur_4777	COG0574	Belongs to the PEP-utilizing enzyme family
Tcur_4777	COG3848	Pyruvate phosphate dikinase
Tcur_4787	COG1595	DNA-templated transcription, initiation
Tcur_4795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Tcur_4796	COG0246	Mannitol dehydrogenase
Tcur_4801	COG2843	Capsule synthesis protein
Tcur_4802	COG1104	cysteine desulfurase activity
Tcur_4810	COG0243	molybdopterin cofactor binding
Tcur_4811	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Tcur_4815	COG1119	ATPase activity
Tcur_4817	COG1714	RDD family
Tcur_4820	COG3830	Belongs to the UPF0237 family
Tcur_4820	COG0560	Phosphoserine phosphatase
Tcur_4823	COG2062	phosphohistidine phosphatase, SixA
Tcur_4825	COG2226	methyltransferase
Tcur_4826	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tcur_4827	COG2172	sigma factor antagonist activity
Tcur_4828	COG1366	Belongs to the anti-sigma-factor antagonist family
Tcur_4829	COG1205	dead DEAH box helicase
Tcur_4829	COG1111	helicase
Tcur_4841	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Tcur_4842	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Tcur_4844	COG0596	Alpha beta hydrolase
Tcur_4850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Tcur_4851	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tcur_4867	COG0019	diaminopimelate decarboxylase activity
Tcur_4870	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tcur_4871	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Tcur_4880	COG0789	Transcriptional regulator
Tcur_4892	COG0464	growth
Tcur_4896	COG1309	transcriptional regulator
Tcur_4902	COG1132	(ABC) transporter
Tcur_4919	COG1408	metallophosphoesterase
Tcur_4921	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tcur_4923	COG0003	Pfam Anion-transporting ATPase
Tcur_4928	COG0180	Tryptophanyl-tRNA synthetase
Tcur_4937	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tcur_4941	COG0590	tRNA wobble adenosine to inosine editing
Tcur_4942	COG0305	Participates in initiation and elongation during chromosome replication
Tcur_4943	COG0534	Mate efflux family protein
Tcur_4946	COG0359	binds to the 23S rRNA
Tcur_4947	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tcur_4949	COG0360	Binds together with S18 to 16S ribosomal RNA
Tcur_4955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tcur_4960	COG0492	ferredoxin-NADP+ reductase activity
Tcur_4963	COG1595	DNA-templated transcription, initiation
Tcur_4968	COG0617	tRNA 3'-terminal CCA addition
Tcur_4971	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Tcur_4975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tcur_4976	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tcur_4978	COG1192	Involved in chromosome partitioning
Tcur_4980	COG0357	Ribosomal RNA small subunit methyltransferase G
Tcur_4982	COG0706	membrane insertase activity
Tcur_4983	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tcur_4984	COG0594	ribonuclease P activity
Tcur_4985	COG0230	Belongs to the bacterial ribosomal protein bL34 family