locus-tag class description COG0536 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG3383 formate dehydrogenase (NAD+) activity COG1071 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor COG0648 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin COG0574 Belongs to the PEP-utilizing enzyme family COG1080 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) COG0663 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily COG0024 Methionine aminopeptidase COG0148 phosphopyruvate hydratase activity COG0499 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine COG0172 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) COG1226 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) COG0541 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0017 Asparaginyl-tRNA synthetase COG0214 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively COG0015 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily COG1343 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette COG0436 Aminotransferase COG0083 homoserine kinase activity COG0626 cystathionine gamma-synthase activity COG0012 GTP binding COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG0501 Belongs to the peptidase M48B family COG1518 maintenance of DNA repeat elements COG4962 Type ii secretion system protein e COG0025 NhaP-type Na H and K H COG0171 NAD+ synthase (glutamine-hydrolyzing) activity COG0190 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate COG1012 belongs to the aldehyde dehydrogenase family COG0134 indole-3-glycerol-phosphate synthase activity COG0512 Glutamine amidotransferase of anthranilate synthase COG0135 phosphoribosylanthranilate isomerase activity COG0547 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) COG2226 methyltransferase COG0531 amino acid COG0531 amino acid COG0004 ammonium transporteR COG0477 Major facilitator Superfamily COG0477 Major facilitator Superfamily COG0477 Major facilitator Superfamily COG0614 abc-type fe3 -hydroxamate transport system, periplasmic component COG0480 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome COG0050 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis COG2896 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate COG1337 RAMP superfamily COG0003 Pfam Anion-transporting ATPase COG0142 geranyltranstransferase activity COG0623 enoyl-[acyl-carrier-protein] reductase (NADH) activity COG0714 Associated with various cellular activities COG0101 tRNA pseudouridine synthase activity COG2265 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family COG0461 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) COG1353 crispr-associated protein COG2271 Major facilitator Superfamily COG2271 Major facilitator Superfamily COG0442 prolyl-tRNA aminoacylation COG0536 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0008 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) COG0519 Catalyzes the synthesis of GMP from XMP COG0017 Asparaginyl-tRNA synthetase COG1250 3-hydroxyacyl-CoA dehydrogenase COG1250 3-hydroxyacyl-CoA dehydrogenase COG0720 synthase COG0603 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) COG0039 L-malate dehydrogenase activity COG0450 alkyl hydroperoxide reductase COG0113 porphobilinogen synthase activity COG1007 ATP synthesis coupled electron transport COG1008 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1009 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit COG1009 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit COG0713 ATP synthesis coupled electron transport COG0839 Belongs to the complex I subunit 6 family COG1143 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0649 NAD binding COG0852 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0377 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0838 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0064 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) COG0252 asparaginase activity COG1960 acyl-CoA dehydrogenase activity COG1960 acyl-CoA dehydrogenase activity COG1960 acyl-CoA dehydrogenase activity COG1960 acyl-CoA dehydrogenase activity COG0620 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation COG0459 protein refolding COG0492 ferredoxin-NADP+ reductase activity COG0109 protoheme IX farnesyltransferase activity COG0102 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly COG0103 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) COG0345 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline COG0554 Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate COG1175 transmembrane transport COG0395 ABC-type sugar transport system, permease component COG3842 ATPase activity COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG1584 GPR1 FUN34 yaaH family protein COG0656 L-ascorbic acid biosynthetic process COG0493 'glutamate synthase COG0477 Major facilitator Superfamily COG1804 L-carnitine dehydratase bile acid-inducible protein F COG2814 Major facilitator Superfamily COG2814 Major facilitator Superfamily COG2267 carboxylic ester hydrolase activity COG0167 dihydroorotate dehydrogenase activity COG0543 2 iron, 2 sulfur cluster binding COG1199 ATP-dependent helicase activity COG1960 acyl-CoA dehydrogenase activity COG0086 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates COG0085 RNA polymerase activity COG0221 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG1052 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family COG2814 Major facilitator Superfamily COG1469 GTP cyclohydrolase I activity COG0615 ADP-L-glycero-beta-D-manno-heptose biosynthetic process COG2870 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose COG0454 -acetyltransferase COG0461 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) COG0143 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0371 Dehydrogenase COG1234 tRNA 3'-trailer cleavage COG0179 Fumarylacetoacetate (FAA) hydrolase COG0045 succinate-CoA ligase (ADP-forming) activity COG1042 CoA-binding domain protein COG1670 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins COG2189 Belongs to the N(4) N(6)-methyltransferase family COG1793 dna ligase COG0531 amino acid COG0531 amino acid COG0531 amino acid COG0531 amino acid COG0531 amino acid COG2414 aldehyde ferredoxin oxidoreductase COG2414 aldehyde ferredoxin oxidoreductase COG0215 cysteine-tRNA ligase activity COG0182 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) COG0062 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration COG0063 ADP-dependent NAD(P)H-hydrate dehydratase activity COG0494 nUDIX hydrolase COG0667 Aldo Keto reductase COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG0177 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate COG0177 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate COG0533 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction COG0127 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions COG0644 oxidoreductase COG2086 electron transfer activity COG2025 fatty acid beta-oxidation using acyl-CoA dehydrogenase COG0441 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) COG1012 belongs to the aldehyde dehydrogenase family COG1454 alcohol dehydrogenase COG0107 imidazoleglycerol-phosphate synthase activity COG0332 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids COG2131 deaminase COG0152 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity COG0407 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III COG0276 Catalyzes the ferrous insertion into protoporphyrin IX COG0041 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) COG0183 Belongs to the thiolase family COG0009 L-threonylcarbamoyladenylate synthase COG0308 aminopeptidase N COG0308 aminopeptidase N COG0513 Belongs to the DEAD box helicase family COG0183 Belongs to the thiolase family COG1960 acyl-CoA dehydrogenase activity COG0318 PFAM AMP-dependent synthetase and ligase COG0318 PFAM AMP-dependent synthetase and ligase COG1250 3-hydroxyacyl-CoA dehydrogenase COG0517 IMP dehydrogenase activity COG0617 tRNA 3'-terminal CCA addition COG0618 3'(2'),5'-bisphosphate nucleotidase activity COG0667 Aldo Keto reductase COG3387 PFAM Glycoside hydrolase 15-related COG0337 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) COG0169 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) COG0164 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids COG0128 3-phosphoshikimate 1-carboxyvinyltransferase activity COG4608 Belongs to the ABC transporter superfamily COG0444 Belongs to the ABC transporter superfamily COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components COG0601 transmembrane transport COG1013 pyruvate-flavodoxin oxidoreductase activity COG1013 pyruvate-flavodoxin oxidoreductase activity COG0674 pyruvate-flavodoxin oxidoreductase activity COG1014 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin COG0674 pyruvate-flavodoxin oxidoreductase activity COG1014 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin COG1027 Aspartate ammonia-lyase COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG2814 Major facilitator Superfamily COG1028 Short-chain dehydrogenase reductase Sdr COG4948 Mandelate Racemase Muconate Lactonizing COG1072 (Pantothenic acid kinase)) COG2876 3-deoxy-7-phosphoheptulonate synthase activity COG2986 histidine ammonia-lyase COG0531 amino acid COG2814 Major facilitator Superfamily COG2987 Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate COG1228 amidohydrolase COG1355 regulation of microtubule-based process COG2078 PFAM AMMECR1 domain protein COG1473 amidohydrolase COG1619 proteins homologs of microcin C7 resistance protein MccF COG2271 Major facilitator Superfamily COG0477 Major facilitator Superfamily COG0477 Major facilitator Superfamily COG1131 (ABC) transporter COG3189 MarR family transcriptional regulator COG1012 belongs to the aldehyde dehydrogenase family COG1812 S-adenosylmethionine synthetase (AdoMet synthetase) COG0516 GMP reductase activity COG0517 IMP dehydrogenase activity COG0516 GMP reductase activity COG0517 IMP dehydrogenase activity COG1060 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate COG1060 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate COG0585 pseudouridine synthase activity COG2086 electron transfer activity COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family COG0719 Fe-S assembly protein COG0396 ATPase activity COG2151 metal-sulfur cluster biosynthetic enzyme COG0247 lactate metabolic process COG2181 nitrate reductase activity COG2271 Major facilitator Superfamily COG1324 tolerance protein COG2189 Belongs to the N(4) N(6)-methyltransferase family COG0596 Alpha beta hydrolase COG1078 dGTPase activity COG1120 ATPase activity COG1765 OsmC-like protein COG0446 pyridine nucleotide-disulphide oxidoreductase COG0591 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family COG2222 sugar isomerase COG1980 fructose-bisphosphate aldolase activity COG0235 Class ii aldolase COG0650 Formate hydrogenlyase subunit 4 COG0651 ATP synthesis coupled electron transport COG0649 NAD binding COG0377 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1007 ATP synthesis coupled electron transport COG3385 transposase activity COG0138 bifunctional purine biosynthesis protein purh COG1961 COG1961 Site-specific recombinases, DNA invertase Pin homologs COG1192 Involved in chromosome partitioning COG0556 nucleotide-excision repair COG0174 glutamine synthetase COG1321 iron dependent repressor COG2038 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity COG0343 queuine tRNA-ribosyltransferase activity COG1129 ABC transporter COG0358 DNA primase activity COG1024 Enoyl-CoA hydratase COG0776 regulation of translation COG0049 tRNA binding COG1131 (ABC) transporter COG0491 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid COG4948 Mandelate Racemase Muconate Lactonizing COG0467 Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction COG0299 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate COG0125 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis COG0626 cystathionine gamma-synthase activity COG1304 FMN binding COG0550 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone COG0263 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate COG1670 COG1670 acetyltransferases, including N-acetylases of ribosomal proteins COG1048 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate COG1171 Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA COG1254 Belongs to the acylphosphatase family COG0538 isocitrate dehydrogenase activity COG1859 Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase COG0462 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) COG1024 Enoyl-CoA hydratase COG1274 phosphoenolpyruvate carboxykinase (GTP) activity COG3842 ATPase activity COG4555 ABC transporter COG0366 Alpha amylase catalytic COG0463 Glycosyl transferase, family 2 COG0477 Major facilitator Superfamily COG0419 ATPase involved in DNA repair COG0160 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family COG0372 Belongs to the citrate synthase family COG3383 formate dehydrogenase (NAD+) activity COG1526 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH COG2264 protein methyltransferase activity COG0537 adenosine 5'-monophosphoramidase activity COG2271 Major facilitator Superfamily COG0003 Pfam Anion-transporting ATPase COG2814 Major facilitator Superfamily COG0588 phosphoglycerate mutase activity COG0206 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity COG0494 nUDIX hydrolase COG0142 geranyltranstransferase activity COG4974 Belongs to the 'phage' integrase family COG0036 Belongs to the ribulose-phosphate 3-epimerase family COG0604 alcohol dehydrogenase COG0047 phosphoribosylformylglycinamidine synthase activity COG0044 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides COG0284 orotidine-5'-phosphate decarboxylase activity COG2264 protein methyltransferase activity COG0078 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline COG0074 Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit COG0045 succinate-CoA ligase (ADP-forming) activity COG0561 phosphatase activity COG0609 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily COG1055 Involved in arsenical resistance. Thought to form the channel of an arsenite pump COG0104 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP COG0509 glycine decarboxylation via glycine cleavage system COG0293 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit COG0518 GMP synthase (glutamine-hydrolyzing) activity COG0519 Catalyzes the synthesis of GMP from XMP COG0602 queuosine metabolic process COG0403 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0689 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates COG0030 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity COG0504 CTP synthase activity COG0087 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit COG0089 rRNA binding COG0090 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0185 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA COG0091 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome COG0092 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation COG0255 Belongs to the universal ribosomal protein uL29 family COG0186 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA COG0093 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome COG0094 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0096 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit COG0097 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center COG0098 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body COG1102 Psort location Cytoplasmic, score COG0130 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs COG0034 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine COG2353 YceI-like domain COG2513 Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate COG0805 protein transport COG1826 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes COG1290 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG0460 homoserine dehydrogenase COG0527 aspartate kinase activity COG1116 anion transmembrane transporter activity COG0673 inositol 2-dehydrogenase activity COG1012 belongs to the aldehyde dehydrogenase family COG1454 alcohol dehydrogenase COG1012 belongs to the aldehyde dehydrogenase family COG0156 8-amino-7-oxononanoate synthase activity COG2271 Major facilitator Superfamily COG2271 Major facilitator Superfamily COG0052 Belongs to the universal ribosomal protein uS2 family COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs COG1586 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine COG0382 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate COG0043 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity COG1185 polyribonucleotide nucleotidyltransferase activity COG0421 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine COG1225 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0081 regulation of translation COG0080 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors COG0693 protein deglycase activity COG0438 transferase activity, transferring glycosyl groups COG1236 Exonuclease of the beta-lactamase fold involved in RNA processing COG1236 Exonuclease of the beta-lactamase fold involved in RNA processing COG0005 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate COG0708 Exodeoxyribonuclease III COG0450 alkyl hydroperoxide reductase COG0037 tRNA processing COG0105 UTP biosynthetic process COG0112 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex COG0451 ADP-glyceromanno-heptose 6-epimerase activity COG0026 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) COG0057 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity COG3634 alkyl hydroperoxide reductase activity COG0446 pyridine nucleotide-disulphide oxidoreductase COG0446 pyridine nucleotide-disulphide oxidoreductase COG0557 exoribonuclease II activity COG0484 heat shock protein binding COG0576 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG2211 Major facilitator Superfamily COG1881 PFAM PEBP family protein COG1030 water channel activity COG0470 DNA polymerase III COG1067 ATP-dependent peptidase activity COG0079 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily COG2060 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane COG2216 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system COG1155 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit COG2156 Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex COG0153 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) COG1090 epimerase COG0352 thiamine-phosphate diphosphorylase activity COG1156 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit COG0351 phosphomethylpyrimidine kinase COG0402 S-adenosylhomocysteine deaminase activity COG1394 ATPase activity, coupled to movement of substances COG0046 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL COG2095 MarC family integral membrane protein COG2095 MarC family integral membrane protein COG0126 phosphoglycerate kinase activity COG0073 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0143 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0010 Belongs to the arginase family COG0187 DNA topoisomerase II activity COG0188 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner COG1335 isochorismatase COG3842 ATPase activity COG1215 transferase activity, transferring glycosyl groups COG0073 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0311 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS COG0006 proline dipeptidase activity COG0404 The glycine cleavage system catalyzes the degradation of glycine COG0099 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0522 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit COG0100 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome COG0303 'Molybdopterin COG0303 'Molybdopterin COG1977 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin COG0075 2-aminoethylphosphonate-pyruvate transaminase activity COG0565 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA COG1032 radical SAM domain protein COG1058 Belongs to the CinA family COG1546 Belongs to the CinA family COG0031 Belongs to the cysteine synthase cystathionine beta- synthase family COG0373 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) COG1139 Iron-sulfur cluster binding protein COG0247 lactate metabolic process COG2181 nitrate reductase activity COG0277 FAD linked oxidase domain protein COG0241 D,D-heptose 1,7-bisphosphate phosphatase COG0020 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids COG0072 phenylalanine-tRNA ligase activity COG0630 type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis COG1994 Peptidase M50 COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate COG0194 GDP metabolic process COG0151 Belongs to the GarS family COG1239 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX COG0540 Belongs to the ATCase OTCase family COG0181 hydroxymethylbilane synthase activity COG0001 glutamate-1-semialdehyde 2,1-aminomutase activity COG0717 Belongs to the dCTP deaminase family COG1607 acyl-coa hydrolase COG1514 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester COG1201 RNA secondary structure unwinding COG1201 RNA secondary structure unwinding COG0589 response to stress COG0183 Belongs to the thiolase family COG0586 Pfam SNARE associated Golgi protein COG1012 belongs to the aldehyde dehydrogenase family COG1522 sequence-specific DNA binding COG0017 Asparaginyl-tRNA synthetase COG0477 Major facilitator Superfamily COG0517 IMP dehydrogenase activity COG0617 tRNA 3'-terminal CCA addition COG0618 3'(2'),5'-bisphosphate nucleotidase activity COG0176 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway COG1154 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) COG3959 Transketolase, thiamine diphosphate binding domain COG0329 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) COG1960 acyl-CoA dehydrogenase activity COG0393 Putative heavy-metal-binding COG0249 that it carries out the mismatch recognition step. This protein has a weak ATPase activity COG2723 6-phospho-beta-galactosidase activity COG1489 DNA binding COG1280 lysine exporter protein (LysE YggA) COG0120 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate COG1312 Catalyzes the dehydration of D-mannonate COG4974 Belongs to the 'phage' integrase family COG4974 Belongs to the 'phage' integrase family COG0657 acetylesterase activity COG1940 carbohydrate kinase activity COG0406 alpha-ribazole phosphatase activity COG1331 Highly conserved protein containing a thioredoxin domain COG1646 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales COG1867 N(2),N(2)-dimethylguanosine tRNA methyltransferase COG0210 DNA helicase COG1473 amidohydrolase COG1832 CoA-binding protein COG0285 dihydrofolate synthase activity COG0334 Belongs to the Glu Leu Phe Val dehydrogenases family COG0334 Belongs to the Glu Leu Phe Val dehydrogenases family COG0495 leucyl-tRNA aminoacylation COG1945 arginine decarboxylase activity COG0281 malic enzyme COG1335 isochorismatase COG1884 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG2185 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG2185 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG1703 isobutyryl-CoA mutase activity COG0661 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis COG1208 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon COG3118 belongs to the thioredoxin family COG1515 deoxyribonuclease V activity COG2379 hydroxypyruvate reductase COG0301 tRNA thio-modification COG0607 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS COG3253 May function as heme-dependent peroxidase COG0206 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity COG1271 oxidase subunit COG0517 IMP dehydrogenase activity COG0312 modulator of DNA gyrase COG0312 modulator of DNA gyrase COG2814 Major facilitator Superfamily COG0505 Belongs to the CarA family COG0019 diaminopimelate decarboxylase activity COG0819 Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway COG1196 nuclear chromosome segregation COG0477 Major facilitator Superfamily COG1502 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol COG0013 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain COG0417 DNA replication proofreading COG0449 glutamine-fructose-6-phosphate transaminase (isomerizing) activity COG1573 uracil-dna glycosylase COG0060 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) COG1144 Oxidoreductase COG0674 pyruvate-flavodoxin oxidoreductase activity COG1013 pyruvate-flavodoxin oxidoreductase activity COG0314 molybdopterin synthase activity COG2226 methyltransferase COG0535 radical SAM domain protein COG0578 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family COG1051 belongs to the nudix hydrolase family COG1056 cytidyltransferase-related domain COG0489 protein tyrosine kinase activity COG0436 Aminotransferase COG2220 Zn-dependent hydrolases of the beta-lactamase fold COG0463 Glycosyl transferase, family 2 COG1387 Histidinol phosphatase and related hydrolases of the PHP family COG1796 DNA polymerase COG2759 Belongs to the formate--tetrahydrofolate ligase family COG0077 Prephenate dehydratase COG1605 Chorismate mutase COG1215 transferase activity, transferring glycosyl groups COG1215 transferase activity, transferring glycosyl groups COG1215 transferase activity, transferring glycosyl groups COG3404 Formiminotransferase-cyclodeaminase COG0463 Glycosyl transferase, family 2 COG1216 Glycosyl transferase, family 2 COG4974 Belongs to the 'phage' integrase family COG0667 Aldo Keto reductase COG0451 ADP-glyceromanno-heptose 6-epimerase activity COG0823 Involved in the tonB-independent uptake of proteins COG1506 peptidase COG4946 Tricorn protease homolog COG0823 Involved in the tonB-independent uptake of proteins COG1506 peptidase COG4946 Tricorn protease homolog COG1235 May be involved in the transport of PQQ or its precursor to the periplasm COG1235 May be involved in the transport of PQQ or its precursor to the periplasm COG0405 Gamma-glutamyltransferase COG0793 Belongs to the peptidase S41A family COG4946 Tricorn protease homolog COG4106 trans-aconitate 2-methyltransferase activity COG1091 dTDP-4-dehydrorhamnose reductase activity COG1215 transferase activity, transferring glycosyl groups COG1887 Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC COG1087 Belongs to the NAD(P)-dependent epimerase dehydratase family COG1804 L-carnitine dehydratase bile acid-inducible protein F COG0119 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) COG2267 carboxylic ester hydrolase activity COG1574 metal-dependent hydrolase with the TIM-barrel fold COG2045 Belongs to the ComB family COG1024 Enoyl-CoA hydratase COG1903 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A COG0007 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme COG1648 precorrin-2 dehydrogenase activity COG1226 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) COG0137 argininosuccinate synthase activity COG0137 argininosuccinate synthase activity COG0165 Argininosuccinate lyase COG3386 PFAM SMP-30 Gluconolaconase COG1350 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine COG2896 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate COG2096 Adenosyltransferase COG1695 Transcriptional regulator COG1321 iron dependent repressor COG0546 phosphoglycolate phosphatase activity COG0476 Involved in molybdopterin and thiamine biosynthesis, family 2 COG1063 alcohol dehydrogenase COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG0182 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) COG2226 methyltransferase COG0279 D-glycero-D-manno-heptose 7-phosphate biosynthetic process COG1131 (ABC) transporter COG1052 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family COG0022 dehydrogenase e1 component COG2391 methyltransferase activity