locus-tag	class	description
Thermo_00001	COG1196	nuclear chromosome segregation
Thermo_00009	COG0560	Phosphoserine phosphatase
Thermo_00010	COG0442	prolyl-tRNA aminoacylation
Thermo_00012	COG1051	belongs to the nudix hydrolase family
Thermo_00012	COG1056	cytidyltransferase-related domain
Thermo_00018	COG0148	phosphopyruvate hydratase activity
Thermo_00020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Thermo_00021	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thermo_00024	COG0470	DNA polymerase III
Thermo_00024	COG1067	ATP-dependent peptidase activity
Thermo_00028	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Thermo_00030	COG0438	transferase activity, transferring glycosyl groups
Thermo_00033	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Thermo_00037	COG1250	3-hydroxyacyl-CoA dehydrogenase
Thermo_00046	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Thermo_00052	COG1793	dna ligase
Thermo_00053	COG0101	tRNA pseudouridine synthase activity
Thermo_00055	COG1028	Short-chain dehydrogenase reductase Sdr
Thermo_00056	COG0495	leucyl-tRNA aminoacylation
Thermo_00057	COG1945	arginine decarboxylase activity
Thermo_00059	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thermo_00061	COG0003	Pfam Anion-transporting ATPase
Thermo_00064	COG0019	diaminopimelate decarboxylase activity
Thermo_00067	COG0281	malic enzyme
Thermo_00070	COG0251	oxidation-reduction process
Thermo_00080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Thermo_00085	COG0167	dihydroorotate dehydrogenase activity
Thermo_00094	COG1598	PFAM Uncharacterised protein family UPF0150
Thermo_00121	COG1078	dGTPase activity
Thermo_00147	COG0183	Belongs to the thiolase family
Thermo_00149	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Thermo_00150	COG0113	porphobilinogen synthase activity
Thermo_00154	COG2222	sugar isomerase
Thermo_00167	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Thermo_00171	COG1980	fructose-bisphosphate aldolase activity
Thermo_00174	COG0047	phosphoribosylformylglycinamidine synthase activity
Thermo_00177	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thermo_00177	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thermo_00178	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thermo_00180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Thermo_00184	COG0285	dihydrofolate synthase activity
Thermo_00191	COG0010	Belongs to the arginase family
Thermo_00193	COG0402	S-adenosylhomocysteine deaminase activity
Thermo_00196	COG0714	Associated with various cellular activities
Thermo_00206	COG2264	protein methyltransferase activity
Thermo_00208	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Thermo_00209	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Thermo_00211	COG0459	protein refolding
Thermo_00212	COG0450	alkyl hydroperoxide reductase
Thermo_00214	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Thermo_00215	COG0805	protein transport
Thermo_00219	COG1007	ATP synthesis coupled electron transport
Thermo_00221	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Thermo_00222	COG0713	ATP synthesis coupled electron transport
Thermo_00224	COG0839	Belongs to the complex I subunit 6 family
Thermo_00225	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thermo_00226	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Thermo_00227	COG0649	NAD binding
Thermo_00228	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thermo_00229	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thermo_00230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thermo_00233	COG0252	asparaginase activity
Thermo_00235	COG1960	acyl-CoA dehydrogenase activity
Thermo_00237	COG1592	Rubrerythrin
Thermo_00244	COG0142	geranyltranstransferase activity
Thermo_00253	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Thermo_00253	COG3608	succinylglutamate desuccinylase aspartoacylase
Thermo_00255	COG2068	MobA-Related Protein
Thermo_00259	COG0477	Major facilitator Superfamily
Thermo_00271	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thermo_00272	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Thermo_00286	COG1335	isochorismatase
Thermo_00288	COG2814	Major facilitator Superfamily
Thermo_00289	COG3842	ATPase activity
Thermo_00291	COG0725	ABC transporter, periplasmic molybdate-binding protein
Thermo_00294	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Thermo_00307	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Thermo_00312	COG2267	carboxylic ester hydrolase activity
Thermo_00313	COG0574	Belongs to the PEP-utilizing enzyme family
Thermo_00313	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Thermo_00316	COG0423	glycine-tRNA ligase activity
Thermo_00318	COG0822	iron-sulfur transferase activity
Thermo_00319	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Thermo_00320	COG0719	Fe-S assembly protein
Thermo_00321	COG0719	Fe-S assembly protein
Thermo_00322	COG0396	ATPase activity
Thermo_00324	COG1072	(Pantothenic acid kinase))
Thermo_00325	COG0477	Major facilitator Superfamily
Thermo_00327	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thermo_00328	COG0156	8-amino-7-oxononanoate synthase activity
Thermo_00329	COG1489	DNA binding
Thermo_00330	COG1324	tolerance protein
Thermo_00331	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Thermo_00332	COG0644	oxidoreductase
Thermo_00333	COG0492	ferredoxin-NADP+ reductase activity
Thermo_00334	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Thermo_00338	COG1832	CoA-binding protein
Thermo_00340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Thermo_00345	COG2271	Major facilitator Superfamily
Thermo_00349	COG2814	Major facilitator Superfamily
Thermo_00350	COG1846	Transcriptional regulator
Thermo_00354	COG0456	acetyltransferase
Thermo_00354	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Thermo_00358	COG3383	formate dehydrogenase (NAD+) activity
Thermo_00360	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Thermo_00366	COG0667	Aldo Keto reductase
Thermo_00369	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Thermo_00379	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Thermo_00382	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Thermo_00389	COG0493	'glutamate synthase
Thermo_00392	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thermo_00392	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Thermo_00393	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Thermo_00395	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Thermo_00404	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Thermo_00405	COG0028	Belongs to the TPP enzyme family
Thermo_00408	COG0477	Major facilitator Superfamily
Thermo_00411	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Thermo_00413	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Thermo_00417	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Thermo_00425	COG0179	Fumarylacetoacetate (FAA) hydrolase
Thermo_00426	COG3185	4-Hydroxyphenylpyruvate dioxygenase
Thermo_00441	COG0072	phenylalanine-tRNA ligase activity
Thermo_00441	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thermo_00450	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Thermo_00453	COG1058	Belongs to the CinA family
Thermo_00453	COG1546	Belongs to the CinA family
Thermo_00458	COG0531	amino acid
Thermo_00464	COG1522	sequence-specific DNA binding
Thermo_00470	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Thermo_00471	COG1597	lipid kinase activity
Thermo_00477	COG0438	transferase activity, transferring glycosyl groups
Thermo_00481	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Thermo_00483	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thermo_00489	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thermo_00491	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Thermo_00492	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thermo_00505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Thermo_00507	COG1091	dTDP-4-dehydrorhamnose reductase activity
Thermo_00511	COG2046	Belongs to the sulfate adenylyltransferase family
Thermo_00512	COG0175	sulfate reduction
Thermo_00513	COG1809	phosphosulfolactate synthase activity
Thermo_00522	COG0463	Glycosyl transferase, family 2
Thermo_00539	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Thermo_00553	COG0579	oxidoreductase
Thermo_00555	COG0028	Belongs to the TPP enzyme family
Thermo_00567	COG0626	cystathionine gamma-synthase activity
Thermo_00568	COG4454	pyrroloquinoline quinone binding
Thermo_00581	COG1131	(ABC) transporter
Thermo_00585	COG0395	ABC-type sugar transport system, permease component
Thermo_00588	COG0412	Dienelactone hydrolase
Thermo_00591	COG0528	UMP kinase activity
Thermo_00600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Thermo_00604	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Thermo_00605	COG0581	inorganic phosphate transmembrane transporter activity
Thermo_00609	COG0589	response to stress
Thermo_00613	COG0586	Pfam SNARE associated Golgi protein
Thermo_00614	COG0477	Major facilitator Superfamily
Thermo_00629	COG0501	Belongs to the peptidase M48B family
Thermo_00655	COG0163	prenyltransferase activity
Thermo_00661	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Thermo_00662	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Thermo_00663	COG0009	L-threonylcarbamoyladenylate synthase
Thermo_00665	COG2814	Major facilitator Superfamily
Thermo_00667	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Thermo_00670	COG0417	DNA replication proofreading
Thermo_00672	COG0644	oxidoreductase
Thermo_00674	COG0343	queuine tRNA-ribosyltransferase activity
Thermo_00675	COG4172	Belongs to the ABC transporter superfamily
Thermo_00677	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Thermo_00678	COG0735	belongs to the Fur family
Thermo_00679	COG1797	cobyrinic acid a,c-diamide synthase activity
Thermo_00680	COG1362	aminopeptidase activity
Thermo_00681	COG0124	histidyl-tRNA synthetase
Thermo_00687	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Thermo_00687	COG0519	Catalyzes the synthesis of GMP from XMP
Thermo_00692	COG3387	PFAM Glycoside hydrolase 15-related
Thermo_00693	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Thermo_00699	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Thermo_00700	COG1024	Enoyl-CoA hydratase
Thermo_00702	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thermo_00703	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Thermo_00704	COG1304	FMN binding
Thermo_00710	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Thermo_00711	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Thermo_00712	COG1394	ATPase activity, coupled to movement of substances
Thermo_00715	COG1269	ATP hydrolysis coupled proton transport
Thermo_00720	COG2814	Major facilitator Superfamily
Thermo_00724	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Thermo_00725	COG2045	Belongs to the ComB family
Thermo_00728	COG0823	Involved in the tonB-independent uptake of proteins
Thermo_00728	COG1506	peptidase
Thermo_00728	COG4946	Tricorn protease homolog
Thermo_00733	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Thermo_00737	COG2151	metal-sulfur cluster biosynthetic enzyme
Thermo_00739	COG0585	pseudouridine synthase activity
Thermo_00740	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Thermo_00741	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Thermo_00743	COG0516	GMP reductase activity
Thermo_00743	COG0517	IMP dehydrogenase activity
Thermo_00751	COG1335	isochorismatase
Thermo_00766	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thermo_00769	COG0527	aspartate kinase activity
Thermo_00770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Thermo_00772	COG0517	IMP dehydrogenase activity
Thermo_00772	COG0516	GMP reductase activity
Thermo_00775	COG1695	Transcriptional regulator
Thermo_00790	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Thermo_00792	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
Thermo_00801	COG2226	methyltransferase
Thermo_00802	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Thermo_00804	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Thermo_00805	COG0135	phosphoribosylanthranilate isomerase activity
Thermo_00806	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Thermo_00807	COG0512	Glutamine amidotransferase of anthranilate synthase
Thermo_00808	COG0134	indole-3-glycerol-phosphate synthase activity
Thermo_00809	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Thermo_00811	COG1012	belongs to the aldehyde dehydrogenase family
Thermo_00812	COG1047	Peptidyl-prolyl cis-trans
Thermo_00813	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Thermo_00815	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Thermo_00816	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Thermo_00834	COG2814	Major facilitator Superfamily
Thermo_00835	COG0473	3-isopropylmalate dehydrogenase activity
Thermo_00836	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thermo_00846	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thermo_00846	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Thermo_00847	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
Thermo_00848	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thermo_00851	COG0277	FAD linked oxidase domain protein
Thermo_00856	COG0489	protein tyrosine kinase activity
Thermo_00864	COG1628	Protein of unknown function DUF99
Thermo_00866	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Thermo_00874	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Thermo_00875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Thermo_00876	COG1053	succinate dehydrogenase
Thermo_00878	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Thermo_00879	COG0066	3-isopropylmalate dehydratase activity
Thermo_00880	COG2271	Major facilitator Superfamily
Thermo_00882	COG4948	Mandelate Racemase Muconate Lactonizing
Thermo_00884	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Thermo_00885	COG0640	Transcriptional regulator
Thermo_00891	COG0321	lipoyl(octanoyl) transferase activity
Thermo_00894	COG0022	dehydrogenase e1 component
Thermo_00895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Thermo_00896	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Thermo_00903	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thermo_00904	COG2086	electron transfer activity
Thermo_00906	COG2181	nitrate reductase activity
Thermo_00906	COG0247	lactate metabolic process
Thermo_00907	COG0183	Belongs to the thiolase family
Thermo_00908	COG1960	acyl-CoA dehydrogenase activity
Thermo_00909	COG1960	acyl-CoA dehydrogenase activity
Thermo_00910	COG2271	Major facilitator Superfamily
Thermo_00911	COG0492	ferredoxin-NADP+ reductase activity
Thermo_00912	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thermo_00916	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Thermo_00917	COG0183	Belongs to the thiolase family
Thermo_00919	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Thermo_00920	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Thermo_00936	COG1695	Transcriptional regulator
Thermo_00946	COG3177	Filamentation induced by cAMP protein fic
Thermo_00949	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Thermo_00952	COG0477	Major facilitator Superfamily
Thermo_00957	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Thermo_00959	COG0730	response to heat
Thermo_00961	COG0584	glycerophosphoryl diester phosphodiesterase
Thermo_00963	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Thermo_00966	COG1228	amidohydrolase
Thermo_00968	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Thermo_00969	COG1027	Aspartate ammonia-lyase
Thermo_00971	COG0674	pyruvate-flavodoxin oxidoreductase activity
Thermo_00971	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Thermo_00972	COG1013	pyruvate-flavodoxin oxidoreductase activity
Thermo_00975	COG4166	transmembrane transport
Thermo_00978	COG4608	Belongs to the ABC transporter superfamily
Thermo_00979	COG0444	Belongs to the ABC transporter superfamily
Thermo_00980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Thermo_00981	COG0601	transmembrane transport
Thermo_00991	COG2353	YceI-like domain
Thermo_00996	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Thermo_00998	COG1522	sequence-specific DNA binding
Thermo_00999	COG0017	Asparaginyl-tRNA synthetase
Thermo_01001	COG2814	Major facilitator Superfamily
Thermo_01002	COG1074	ATP-dependent DNA helicase activity
Thermo_01009	COG2226	methyltransferase
Thermo_01012	COG0436	Aminotransferase
Thermo_01014	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Thermo_01015	COG0492	ferredoxin-NADP+ reductase activity
Thermo_01016	COG3118	belongs to the thioredoxin family
Thermo_01026	COG1028	Short-chain dehydrogenase reductase Sdr
Thermo_01031	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Thermo_01032	COG2814	Major facilitator Superfamily
Thermo_01034	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Thermo_01041	COG2169	Transcriptional regulator
Thermo_01041	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Thermo_01052	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Thermo_01058	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Thermo_01059	COG0018	arginyl-trna synthetase
Thermo_01067	COG0004	ammonium transporteR
Thermo_01072	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Thermo_01073	COG2255	four-way junction helicase activity
Thermo_01075	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Thermo_01076	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thermo_01080	COG0126	phosphoglycerate kinase activity
Thermo_01090	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Thermo_01091	COG1518	maintenance of DNA repeat elements
Thermo_01102	COG2255	four-way junction helicase activity
Thermo_01104	COG1960	acyl-CoA dehydrogenase activity
Thermo_01108	COG1122	ATPase activity
Thermo_01112	COG2271	Major facilitator Superfamily
Thermo_01114	COG0446	pyridine nucleotide-disulphide oxidoreductase
Thermo_01120	COG1051	belongs to the nudix hydrolase family
Thermo_01122	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Thermo_01123	COG0174	glutamine synthetase
Thermo_01134	COG1122	ATPase activity
Thermo_01135	COG0504	CTP synthase activity
Thermo_01139	COG2423	ornithine cyclodeaminase activity
Thermo_01141	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
Thermo_01142	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Thermo_01142	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Thermo_01143	COG0318	PFAM AMP-dependent synthetase and ligase
Thermo_01146	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Thermo_01149	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thermo_01151	COG0024	Methionine aminopeptidase
Thermo_01152	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Thermo_01154	COG2814	Major facilitator Superfamily
Thermo_01157	COG0626	cystathionine gamma-synthase activity
Thermo_01166	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thermo_01168	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Thermo_01169	COG1598	PFAM Uncharacterised protein family UPF0150
Thermo_01172	COG1131	(ABC) transporter
Thermo_01173	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Thermo_01181	COG1131	(ABC) transporter
Thermo_01188	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Thermo_01189	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thermo_01190	COG0284	orotidine-5'-phosphate decarboxylase activity
Thermo_01193	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Thermo_01194	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Thermo_01195	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Thermo_01199	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thermo_01201	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Thermo_01203	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Thermo_01204	COG0708	Exodeoxyribonuclease III
Thermo_01205	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Thermo_01206	COG0538	isocitrate dehydrogenase activity
Thermo_01220	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Thermo_01222	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Thermo_01228	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Thermo_01229	COG1185	polyribonucleotide nucleotidyltransferase activity
Thermo_01230	COG1185	polyribonucleotide nucleotidyltransferase activity
Thermo_01250	COG3842	ATPase activity
Thermo_01255	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Thermo_01257	COG1703	isobutyryl-CoA mutase activity
Thermo_01258	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thermo_01258	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thermo_01259	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thermo_01259	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Thermo_01262	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Thermo_01263	COG0604	alcohol dehydrogenase
Thermo_01264	COG4974	Belongs to the 'phage' integrase family
Thermo_01265	COG0142	geranyltranstransferase activity
Thermo_01266	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Thermo_01269	COG1199	ATP-dependent helicase activity
Thermo_01270	COG0038	chloride channel
Thermo_01271	COG0456	acetyltransferase
Thermo_01272	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Thermo_01273	COG0138	bifunctional purine biosynthesis protein purh
Thermo_01286	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Thermo_01295	COG1131	(ABC) transporter
Thermo_01302	COG2890	protein-(glutamine-N5) methyltransferase activity
Thermo_01310	COG1254	Belongs to the acylphosphatase family
Thermo_01311	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Thermo_01316	COG2271	Major facilitator Superfamily
Thermo_01319	COG2814	Major facilitator Superfamily
Thermo_01323	COG1505	serine-type exopeptidase activity
Thermo_01329	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Thermo_01334	COG0463	Glycosyl transferase, family 2
Thermo_01335	COG0419	ATPase involved in DNA repair
Thermo_01339	COG0405	Gamma-glutamyltransferase
Thermo_01340	COG1012	belongs to the aldehyde dehydrogenase family
Thermo_01343	COG1355	regulation of microtubule-based process
Thermo_01344	COG2078	PFAM AMMECR1 domain protein
Thermo_01346	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thermo_01348	COG1501	Belongs to the glycosyl hydrolase 31 family
Thermo_01351	COG0601	transmembrane transport
Thermo_01354	COG1501	Belongs to the glycosyl hydrolase 31 family
Thermo_01360	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Thermo_01361	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Thermo_01362	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thermo_01363	COG4948	Mandelate Racemase Muconate Lactonizing
Thermo_01364	COG1012	belongs to the aldehyde dehydrogenase family
Thermo_01366	COG0673	inositol 2-dehydrogenase activity
Thermo_01367	COG2814	Major facilitator Superfamily
Thermo_01370	COG2271	Major facilitator Superfamily
Thermo_01372	COG2721	sulfolactate sulfo-lyase activity
Thermo_01373	COG2186	Transcriptional regulator
Thermo_01374	COG4948	Mandelate Racemase Muconate Lactonizing
Thermo_01375	COG0519	Catalyzes the synthesis of GMP from XMP
Thermo_01376	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Thermo_01377	COG2890	protein-(glutamine-N5) methyltransferase activity
Thermo_01383	COG1846	Transcriptional regulator
Thermo_01394	COG0049	tRNA binding
Thermo_01396	COG0012	GTP binding
Thermo_01400	COG0315	cyclic pyranopterin monophosphate synthase activity
Thermo_01404	COG0303	'Molybdopterin
Thermo_01406	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Thermo_01407	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thermo_01408	COG0314	molybdopterin synthase activity
Thermo_01420	COG1131	(ABC) transporter
Thermo_01422	COG3189	MarR family transcriptional regulator
Thermo_01423	COG0083	homoserine kinase activity
Thermo_01424	COG0626	cystathionine gamma-synthase activity
Thermo_01429	COG0667	Aldo Keto reductase
Thermo_01444	COG2095	MarC family integral membrane protein
Thermo_01449	COG0509	glycine decarboxylation via glycine cleavage system
Thermo_01450	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Thermo_01456	COG0358	DNA primase activity
Thermo_01461	COG0535	radical SAM domain protein
Thermo_01463	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Thermo_01465	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Thermo_01466	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Thermo_01470	COG0644	oxidoreductase
Thermo_01472	COG2086	electron transfer activity
Thermo_01473	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Thermo_01474	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Thermo_01475	COG2986	histidine ammonia-lyase
Thermo_01491	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Thermo_01493	COG0089	rRNA binding
Thermo_01494	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Thermo_01495	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Thermo_01496	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Thermo_01497	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Thermo_01498	COG0255	Belongs to the universal ribosomal protein uL29 family
Thermo_01502	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Thermo_01507	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Thermo_01508	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Thermo_01512	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Thermo_01513	COG1841	ribosomal large subunit assembly
Thermo_01518	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Thermo_01520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Thermo_01527	COG0535	radical SAM domain protein
Thermo_01532	COG1028	Short-chain dehydrogenase reductase Sdr
Thermo_01535	COG1185	polyribonucleotide nucleotidyltransferase activity
Thermo_01549	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Thermo_01557	COG0085	RNA polymerase activity
Thermo_01558	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thermo_01559	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Thermo_01569	COG0181	hydroxymethylbilane synthase activity
Thermo_01570	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Thermo_01575	COG0109	protoheme IX farnesyltransferase activity
Thermo_01578	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Thermo_01581	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Thermo_01582	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Thermo_01583	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Thermo_01585	COG0483	inositol monophosphate 1-phosphatase activity
Thermo_01586	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Thermo_01588	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
Thermo_01591	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
Thermo_01593	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Thermo_01597	COG0017	Asparaginyl-tRNA synthetase
Thermo_01601	COG0308	aminopeptidase N
Thermo_01602	COG1131	(ABC) transporter
Thermo_01606	COG1250	3-hydroxyacyl-CoA dehydrogenase
Thermo_01609	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thermo_01618	COG0318	PFAM AMP-dependent synthetase and ligase
Thermo_01619	COG1960	acyl-CoA dehydrogenase activity
Thermo_01630	COG0513	Belongs to the DEAD box helicase family
Thermo_01637	COG1132	(ABC) transporter
Thermo_01638	COG1132	(ABC) transporter
Thermo_01641	COG0183	Belongs to the thiolase family
Thermo_01656	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Thermo_01700	COG1322	Protein conserved in bacteria
Thermo_01706	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Thermo_01739	COG1960	acyl-CoA dehydrogenase activity
Thermo_01740	COG0557	exoribonuclease II activity
Thermo_01746	COG1201	RNA secondary structure unwinding
Thermo_01753	COG0546	phosphoglycolate phosphatase activity
Thermo_01756	COG0215	cysteine-tRNA ligase activity
Thermo_01757	COG1956	GAF domain-containing protein
Thermo_01758	COG2814	Major facilitator Superfamily
Thermo_01759	COG0588	phosphoglycerate mutase activity
Thermo_01761	COG1331	Highly conserved protein containing a thioredoxin domain
Thermo_01772	COG0366	Alpha amylase catalytic
Thermo_01773	COG0366	Alpha amylase catalytic
Thermo_01774	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Thermo_01781	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Thermo_01783	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Thermo_01788	COG0351	phosphomethylpyrimidine kinase
Thermo_01788	COG0352	thiamine-phosphate diphosphorylase activity
Thermo_01791	COG1012	belongs to the aldehyde dehydrogenase family
Thermo_01792	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Thermo_01792	COG1796	DNA polymerase
Thermo_01793	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Thermo_01795	COG1131	(ABC) transporter
Thermo_01807	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
Thermo_01810	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Thermo_01811	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Thermo_01815	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thermo_01815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Thermo_01817	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Thermo_01822	COG1201	RNA secondary structure unwinding
Thermo_01824	COG1234	tRNA 3'-trailer cleavage
Thermo_01825	COG0717	Belongs to the dCTP deaminase family
Thermo_01829	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thermo_01830	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Thermo_01831	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Thermo_01832	COG0017	Asparaginyl-tRNA synthetase
Thermo_01840	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Thermo_01841	COG0039	L-malate dehydrogenase activity
Thermo_01843	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Thermo_01844	COG0051	transcription antitermination factor activity, RNA binding
Thermo_01845	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Thermo_01846	COG0668	transmembrane transport
Thermo_01862	COG1120	ATPase activity
Thermo_01863	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Thermo_01865	COG1078	dGTPase activity
Thermo_01870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Thermo_01871	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thermo_01872	COG1469	GTP cyclohydrolase I activity
Thermo_01875	COG4106	trans-aconitate 2-methyltransferase activity
Thermo_01882	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Thermo_01883	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Thermo_01893	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thermo_01894	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Thermo_01896	COG0179	Fumarylacetoacetate (FAA) hydrolase
Thermo_01898	COG0650	Formate hydrogenlyase subunit 4
Thermo_01900	COG0651	ATP synthesis coupled electron transport
Thermo_01901	COG0649	NAD binding
Thermo_01902	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Thermo_01903	COG0651	ATP synthesis coupled electron transport
Thermo_01904	COG0372	Belongs to the citrate synthase family
Thermo_01907	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Thermo_01909	COG0477	Major facilitator Superfamily
Thermo_01913	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Thermo_01916	COG3958	Transketolase
Thermo_01917	COG3959	Transketolase, thiamine diphosphate binding domain
Thermo_01918	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Thermo_01920	COG0318	PFAM AMP-dependent synthetase and ligase
Thermo_01923	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Thermo_01925	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Thermo_01928	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Thermo_01934	COG0540	Belongs to the ATCase OTCase family
Thermo_01944	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
Thermo_01946	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
Thermo_01954	COG1607	acyl-coa hydrolase
Thermo_01955	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Thermo_01962	COG1252	NADH dehydrogenase
Thermo_01964	COG0028	Belongs to the TPP enzyme family
Thermo_01965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Thermo_01966	COG0492	ferredoxin-NADP+ reductase activity
Thermo_01970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Thermo_01971	COG1140	nitrate reductase beta subunit
Thermo_01972	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Thermo_01973	COG2181	nitrate reductase activity
Thermo_01984	COG3189	MarR family transcriptional regulator
Thermo_01985	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Thermo_01995	COG2379	hydroxypyruvate reductase
Thermo_01996	COG1054	Belongs to the UPF0176 family
Thermo_01998	COG1335	isochorismatase
Thermo_02012	COG0187	DNA topoisomerase II activity
Thermo_02013	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Thermo_02015	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Thermo_02020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Thermo_02021	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Thermo_02022	COG0505	Belongs to the CarA family
Thermo_02023	COG1252	NADH dehydrogenase
Thermo_02024	COG2427	Protein of unknown function (DUF1641)
Thermo_02034	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Thermo_02035	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Thermo_02036	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Thermo_02037	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Thermo_02042	COG1028	Short-chain dehydrogenase reductase Sdr
Thermo_02046	COG2409	Drug exporters of the RND superfamily
Thermo_02051	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Thermo_02052	COG0602	queuosine metabolic process
Thermo_02053	COG0006	proline dipeptidase activity
Thermo_02060	COG1131	(ABC) transporter
Thermo_02068	COG1598	PFAM Uncharacterised protein family UPF0150
Thermo_02074	COG1131	(ABC) transporter
Thermo_02078	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Thermo_02080	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Thermo_02083	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Thermo_02084	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Thermo_02087	COG0183	Belongs to the thiolase family
Thermo_02088	COG1024	Enoyl-CoA hydratase
Thermo_02089	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family