locus-tag	class	description
TTX_0003	ENOG4107YZX	Universal stress protein
TTX_0005	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TTX_0012	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TTX_0013	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TTX_0014	ENOG4105KME	endoribonuclease L-psp
TTX_0025	ENOG4108RKS	Short-chain dehydrogenase reductase Sdr
TTX_0025a	ENOG4108Q5Y	Membrane
TTX_0033	ENOG4105DPX	Hydrogenase, large subunit
TTX_0034	ENOG4108USZ	hydrogenase
TTX_0038	ENOG4107R7Y	intracellular protease Pfpi family
TTX_0039	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
TTX_0040	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
TTX_0046	ENOG4105DB1	molybdopterin oxidoreductase
TTX_0047	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TTX_0051	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TTX_0052	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TTX_0060	ENOG4105EVU	fructokinase
TTX_0065	ENOG4108JJB	ABC transporter
TTX_0066	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
TTX_0068	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TTX_0069	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTX_0073	ENOG4107QY8	reductase
TTX_0074	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TTX_0079	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TTX_0083	ENOG4105DEF	Extracellular solute-binding protein, family 5
TTX_0084	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TTX_0085	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TTX_0086	ENOG4105C3U	ABC transporter
TTX_0090	ENOG4107SET	aldo keto reductase
TTX_0091	ENOG4105DBV	ornithine carbamoyltransferase
TTX_0093	ENOG4105K59	histidine triad (HIT) protein
TTX_0096	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
TTX_0101	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
TTX_0104	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TTX_0106	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TTX_0110	ENOG4105D22	carbon starvation protein
TTX_0112	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
TTX_0113	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
TTX_0118	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TTX_0120	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TTX_0121	ENOG4107U4Q	acetylglutamate kinase
TTX_0123	ENOG4105CDH	Citrulline--aspartate ligase
TTX_0126	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TTX_0128	ENOG4107SDT	Homocitrate synthase
TTX_0129	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TTX_0130	ENOG4105C7K	acetolactate synthase
TTX_0132	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
TTX_0133	ENOG4105CM2	brancheD-chain amino acid aminotransferase
TTX_0134	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TTX_0136	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TTX_0137	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
TTX_0139	ENOG4107R0K	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)
TTX_0142	ENOG4105C4M	(Ubiquinol oxidase) subunit I
TTX_0145	ENOG4105D3R	alkyl hydroperoxide reductase
TTX_0156	ENOG4108I5X	binding-protein-dependent transport systems inner membrane Component
TTX_0157	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TTX_0163	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TTX_0168	ENOG4105CQ2	DNA polymerase
TTX_0174	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TTX_0182	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
TTX_0183	ENOG4107QZT	geranylgeranyl reductase
TTX_0184	ENOG4107W7X	Aldolase
TTX_0189	ENOG4105I1K	ABC transporter
TTX_0190	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TTX_0192	ENOG4105CQS	hydrogenase expression formation protein HypD
TTX_0194	ENOG4108JJB	ABC transporter
TTX_0197	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
TTX_0198	ENOG4105MRR	Transcriptional regulator (By similarity)
TTX_0200	ENOG4105D1F	ATP-binding protein
TTX_0202	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TTX_0205	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TTX_0206	ENOG4105D65	subunit l
TTX_0207	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TTX_0208	ENOG4105EJ5	oxidoreductase gamma subunit
TTX_0209	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TTX_0210	ENOG4105DDK	oxidoreductase, beta subunit
TTX_0211	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TTX_0212	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
TTX_0214	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TTX_0215	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TTX_0217	ENOG41088YS	Glycosyl transferase (Group 1
TTX_0219	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
TTX_0220	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TTX_0227	ENOG4105CE1	Ferrous iron transport protein b
TTX_0230	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
TTX_0250	ENOG4105CSA	Coproporphyrinogen iii oxidase
TTX_0251	ENOG4107XWS	modD protein
TTX_0254	ENOG4105CGB	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)
TTX_0255	ENOG4105E0A	ABC, transporter
TTX_0256	ENOG4108U1V	ABC transporter, permease
TTX_0264	ENOG4107QTF	adenylosuccinate lyase
TTX_0277	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TTX_0281	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TTX_0285	ENOG4107TE1	transport protein
TTX_0287	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
TTX_0288	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
TTX_0289	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
TTX_0291	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
TTX_0292	ENOG4107XWS	modD protein
TTX_0293	ENOG4108IYU	L-aspartate oxidase
TTX_0294	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TTX_0296	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TTX_0297	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
TTX_0298	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TTX_0298a	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TTX_0300	ENOG4105CAQ	asparagine synthetase
TTX_0304	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TTX_0307	ENOG4108V1U	phospholipid-binding protein
TTX_0317	ENOG4105CGU	Enoyl-CoA hydratase
TTX_0318	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
TTX_0325	ENOG4105ETU	transcriptional activator (TenA
TTX_0326	ENOG4105C7W	Xanthine dehydrogenase
TTX_0329	ENOG4105CPQ	Dehydrogenase
TTX_0334	ENOG4107QN2	dihydrolipoyl dehydrogenase
TTX_0340	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
TTX_0352	ENOG4107104	thymidine kinase
TTX_0353	ENOG4107SET	aldo keto reductase
TTX_0356	ENOG4108VUY	thioesterase Superfamily protein
TTX_0361	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
TTX_0374	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TTX_0383	ENOG4105CJ1	ABC, transporter
TTX_0389	ENOG4108IUZ	ABC transporter
TTX_0390	ENOG4105C0Z	ABC transporter
TTX_0399	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
TTX_0407	ENOG4108375	Acylphosphatase (EC 3.6.1.7)
TTX_0408	ENOG41084XP	SirA-like domain-containing protein
TTX_0410	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
TTX_0414	ENOG4105VFE	sira family
TTX_0415	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
TTX_0423	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
TTX_0424	ENOG4105CY1	sulfite reductase, dissimilatory-type alpha subunit
TTX_0427	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
TTX_0441	ENOG4107RIQ	Sulfate adenylate transferase
TTX_0455	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TTX_0459	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
TTX_0462	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
TTX_0466	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
TTX_0467	ENOG4105CH7	arginosuccinase
TTX_0472	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TTX_0474	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TTX_0483	ENOG4105C32	Amino acid ABC transporter (Permease)
TTX_0485	ENOG4105C0Z	ABC transporter
TTX_0486	ENOG4108IV0	ABC, transporter
TTX_0488	ENOG4108FN7	Aldo keto reductase
TTX_0491	ENOG4105FDK	ABC transporter
TTX_0493	ENOG4107QM5	aconitate hydratase
TTX_0497	ENOG4105BZN	citrate synthase
TTX_0505	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
TTX_0511	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
TTX_0514	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TTX_0523	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TTX_0534	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TTX_0535	ENOG4105DZ0	fad dependent oxidoreductase
TTX_0539	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TTX_0540	ENOG4105VUC	UPF0237 protein
TTX_0541	ENOG4105CAG	UPF0210 protein
TTX_0544	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TTX_0547	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TTX_0552	ENOG4105ERH	Fumarylacetoacetate hydrolase
TTX_0556	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TTX_0557	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
TTX_0561	ENOG4108JPZ	Monovalent cation H antiporter subunit D
TTX_0562	ENOG4105D65	subunit l
TTX_0563	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TTX_0564	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TTX_0565	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TTX_0570	ENOG4105C1G	acyl-Coa dehydrogenase
TTX_0574	ENOG4108J2R	molybdopterin oxidoreductase
TTX_0588	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TTX_0592	ENOG4105D0M	Protease HtpX homolog
TTX_0610	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TTX_0612	ENOG4108S4H	thioesterase Superfamily protein
TTX_0613	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TTX_0615	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TTX_0618	ENOG4105CIF	Ornithine Cyclodeaminase
TTX_0620	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TTX_0621	ENOG4108V1U	phospholipid-binding protein
TTX_0623	ENOG4105C8Y	Acetylornithine aminotransferase
TTX_0624	ENOG4105C4K	Nad synthetase
TTX_0625	ENOG4105C4K	Nad synthetase
TTX_0627	ENOG4105C5F	glutamine synthetase
TTX_0628	ENOG4105CBC	glutamate synthase
TTX_0630	ENOG4105U3E	Transcriptional regulator
TTX_0634	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
TTX_0637	ENOG4105CBC	glutamate synthase
TTX_0639	ENOG4108ZCA	Inherit from COG: pyridine nucleotide-disulfide oxidoreductase
TTX_0644	ENOG4105PW4	Sugar fermentation stimulation protein homolog
TTX_0649	ENOG4105D64	Mechanosensitive ion channel
TTX_0650	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TTX_0651	ENOG4105EEI	dihydropteroate synthase
TTX_0654	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TTX_0655	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TTX_0656	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TTX_0657	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TTX_0677	ENOG4105DHP	deoxycytidine triphosphate deaminase
TTX_0683	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TTX_0686	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
TTX_0690	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TTX_0691	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
TTX_0692	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
TTX_0707	ENOG4105EN6	Membrane
TTX_0710	ENOG4105FDK	ABC transporter
TTX_0719	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TTX_0730	ENOG4105BZJ	Electron transfer flavoprotein
TTX_0735	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
TTX_0740	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TTX_0741	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TTX_0755	ENOG4105EYH	Exonuclease
TTX_0758	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TTX_0760	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TTX_0762	ENOG4107R13	MMPL domain protein
TTX_0764	ENOG4105DC8	reductase
TTX_0770	ENOG4107QX8	SPFH domain, Band 7 family protein
TTX_0771	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TTX_0776	ENOG4105EHU	Circadian clock protein KaiC
TTX_0777	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TTX_0778	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
TTX_0779	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
TTX_0780	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TTX_0781	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
TTX_0783	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
TTX_0784	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
TTX_0785	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
TTX_0786	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TTX_0787	ENOG4105F4P	)-transporter
TTX_0788	ENOG4105D1Z	hydroxypyruvate reductase
TTX_0789	ENOG4105C01	Dihydroxy-acid dehydratase
TTX_0792	ENOG4105CHR	reductase
TTX_0793	ENOG4105CSH	Transporter
TTX_0794	ENOG4105CQB	FAD linked oxidase domain protein
TTX_0796	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
TTX_0798	ENOG4108DJF	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TTX_0799	ENOG4108R9M	Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity)
TTX_0800	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
TTX_0801	ENOG4105CXT	aspartate transcarbamylase
TTX_0808	ENOG4105CUT	histidyl-tRNA synthetase
TTX_0820	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TTX_0821	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
TTX_0828	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TTX_0831	ENOG4105CV8	reductase
TTX_0833	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
TTX_0837	ENOG4105CPQ	Dehydrogenase
TTX_0839	ENOG4107S4Y	M20 DapE family protein YgeY
TTX_0845	ENOG4105E1V	na solute symporter
TTX_0849	ENOG4105CHM	Aminotransferase
TTX_0851	ENOG4107QRT	dEAD DEAH box helicase
TTX_0854	ENOG4108I5D	sulfate abc transporter
TTX_0855	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TTX_0857	ENOG4105DWF	phosphomethylpyrimidine kinase
TTX_0858	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TTX_0860	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
TTX_0880	ENOG4105CSM	endonuclease III
TTX_0883	ENOG4105CTD	carboxy-peptidase
TTX_0907	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
TTX_0910	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TTX_0911	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TTX_0920	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
TTX_0921	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
TTX_0922	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
TTX_0923	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
TTX_0924	ENOG4105C7B	Threonine dehydratase
TTX_0925	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TTX_0927	ENOG41090R7	Ferric uptake
TTX_0929	ENOG4105C1J	atp-dependent rna helicase
TTX_0932	ENOG4107R56	PP-loop domain protein
TTX_0934	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
TTX_0944	ENOG4108JPW	Aminotransferase
TTX_0949	ENOG4105CY0	Metallo-Beta-Lactamase
TTX_0953	ENOG4105C5S	asparaginyl-tRNA synthetase
TTX_0954	ENOG41068KF	Universal stress protein
TTX_0957	ENOG4105M6F	mutator MutT protein
TTX_0958	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
TTX_0974	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
TTX_0976	ENOG4105CD8	aminopeptidase N
TTX_0977	ENOG4105D5M	phosphate starvation-inducible protein
TTX_0978	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TTX_0980	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TTX_0986	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TTX_0994	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
TTX_0995	ENOG4108S0S	Nucleotidyl transferase
TTX_0999	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
TTX_1000	ENOG4105C5S	asparaginyl-tRNA synthetase
TTX_1003	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TTX_1005	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TTX_1005a	ENOG4105DGU	Histone deacetylase
TTX_1010	ENOG4105WCJ	ec 1.1.1.193
TTX_1011	ENOG4107RDF	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
TTX_1014	ENOG4108R96	Methyltransferase, YaeB family
TTX_1016	ENOG4105M6F	mutator MutT protein
TTX_1021	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
TTX_1024	ENOG4105C1G	acyl-Coa dehydrogenase
TTX_1025	ENOG4105CEY	Amp-dependent synthetase and ligase
TTX_1026	ENOG4105CEY	Amp-dependent synthetase and ligase
TTX_1027	ENOG4105CN9	Peptidase m42 family protein
TTX_1028	ENOG4105E39	Enoyl-CoA hydratase
TTX_1029	ENOG4105CHU	acetyl-coa acetyltransferase
TTX_1040	ENOG4105J5G	Transferase hexapeptide repeat containing protein
TTX_1041	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TTX_1043	ENOG4105CN9	Peptidase m42 family protein
TTX_1047	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TTX_1050	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TTX_1058	ENOG4105C8T	Leucyl-tRNA synthetase
TTX_1059	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TTX_1062	ENOG4105CJ1	ABC, transporter
TTX_1071	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TTX_1072	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TTX_1074a	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TTX_1075	ENOG4108IJ9	(ABC) transporter
TTX_1078	ENOG4107R34	abc transporter permease protein
TTX_1079	ENOG4107QZT	geranylgeranyl reductase
TTX_1082	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
TTX_1083	ENOG4105D9G	High-affinity
TTX_1087	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TTX_1088	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
TTX_1090	ENOG4105E4R	Precorrin-3B C17-methyltransferase
TTX_1091	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
TTX_1092	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TTX_1094	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
TTX_1095	ENOG4105D82	Glutamate dehydrogenase
TTX_1100	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TTX_1101	ENOG4105C26	Dehydrogenase
TTX_1108	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TTX_1109	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TTX_1114	ENOG4105C1G	acyl-Coa dehydrogenase
TTX_1117	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TTX_1120	ENOG4105DIH	basic membrane
TTX_1121	ENOG4108JQ9	ABC transporter
TTX_1122	ENOG4105UIB	(ABC) transporter
TTX_1124	ENOG4105CSH	Transporter
TTX_1126	ENOG41079KZ	Major Facilitator Superfamily
TTX_1128	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
TTX_1139	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TTX_1141	ENOG4105C32	Amino acid ABC transporter (Permease)
TTX_1144	ENOG4105C0Z	ABC transporter
TTX_1145	ENOG4108IV0	ABC, transporter
TTX_1147	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TTX_1154	ENOG4105EW9	transcriptional regulator AsnC family
TTX_1156	ENOG4105CXK	mandelate racemase muconate lactonizing
TTX_1156a	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TTX_1159	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
TTX_1164	ENOG4105C5X	domain protein
TTX_1169	ENOG4105C26	Dehydrogenase
TTX_1176	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
TTX_1185	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
TTX_1187	ENOG4105PJW	Sulfite reductase dissimilatory-type beta subunit
TTX_1198	ENOG4105E8R	UPF0173 metal-dependent hydrolase
TTX_1199	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
TTX_1202	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TTX_1203	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
TTX_1208	ENOG4105F10	Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)
TTX_1209	ENOG4107WZZ	SMC domain protein
TTX_1217	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
TTX_1263	ENOG4108M3J	Dehydrogenase
TTX_1266	ENOG4105CNU	cell division protein FtsK
TTX_1268	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TTX_1269	ENOG4108IEG	Formate dehydrogenase Alpha subunit
TTX_1270	ENOG4107QIZ	NADH dehydrogenase
TTX_1271	ENOG4105D63	family UPF0324
TTX_1277	ENOG4105CTQ	phosphohexokinase
TTX_1278	ENOG41061GT	Aldolase
TTX_1279	ENOG4105EM7	Selenocysteine-specific translation elongation factor
TTX_1281	ENOG4107S7U	Sulfide dehydrogenase
TTX_1283	ENOG4105C4K	Nad synthetase
TTX_1285	ENOG4105BZU	Histidine kinase
TTX_1288	ENOG4105BZU	Histidine kinase
TTX_1294	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TTX_1295	ENOG4105C9Q	fumarate hydratase class II
TTX_1296	ENOG4105CSH	Transporter
TTX_1301	ENOG4107QJE	Chromosome Partitioning Protein
TTX_1304	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
TTX_1316	ENOG4107QP3	malate synthase g
TTX_1317	ENOG4105CQB	FAD linked oxidase domain protein
TTX_1321	ENOG4105DAA	L-lactate
TTX_1322	ENOG4105K4P	CoA-binding domain protein
TTX_1333	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
TTX_1334	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
TTX_1336	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
TTX_1349	ENOG4105H63	Glycosyl transferase, family 2
TTX_1350	ENOG4107R8N	Glycosyl transferase, family 2
TTX_1354	ENOG4107RGC	Glycosyl transferase, family 2
TTX_1357	ENOG4107T8Q	Glycosyl transferase (Group 1
TTX_1358	ENOG4107BJW	polysaccharide deacetylase
TTX_1359	ENOG4105CPK	Glycosyl transferase (Group 1
TTX_1362	ENOG4105E2K	Glycosyl transferase (Group 1
TTX_1363	ENOG4105Q84	sucrose synthase
TTX_1384	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TTX_1395	ENOG4105E8R	UPF0173 metal-dependent hydrolase
TTX_1396	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TTX_1400	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
TTX_1402	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
TTX_1403	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TTX_1404	ENOG4108I0Q	anthranilate phosphoribosyltransferase
TTX_1405	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
TTX_1407	ENOG4105D3W	isochorismatase
TTX_1408	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TTX_1410	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TTX_1424	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TTX_1426	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TTX_1427	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TTX_1430	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TTX_1433	ENOG4107QRT	dEAD DEAH box helicase
TTX_1435	ENOG4105CI0	Citrate lyase
TTX_1436	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
TTX_1438	ENOG4105CSH	Transporter
TTX_1444	ENOG4105JRK	feS assembly protein SufD
TTX_1445	ENOG41062IR	nudix hydrolase
TTX_1447	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TTX_1449	ENOG4105DVT	helicase
TTX_1450	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
TTX_1453	ENOG4105E0I	Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)
TTX_1454	ENOG4105DQU	oxidoreductase, subunit beta
TTX_1455	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TTX_1457	ENOG4105D1H	recombination factor protein RarA
TTX_1458	ENOG4107VMB	Beta-lactamase domain protein
TTX_1459	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TTX_1463	ENOG4105EUJ	GTP cyclohydrolase i
TTX_1466	ENOG4105K64	Glycosyl transferase, family 2
TTX_1471	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TTX_1473	ENOG4108K3F	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TTX_1485	ENOG4105D1H	recombination factor protein RarA
TTX_1489	ENOG4108HMX	isocitrate dehydrogenase (NADP)
TTX_1494	ENOG4108JU3	Alkyl hydroperoxide reductase
TTX_1495	ENOG4105DXD	2-methylcitrate dehydratase
TTX_1496	ENOG4105CR4	methylisocitrate lyase
TTX_1513	ENOG4105BZN	citrate synthase
TTX_1514	ENOG4105C6K	Malic enzyme
TTX_1518	ENOG4108MDK	Dehydrogenase
TTX_1527	ENOG4107TIA	phenylalanyl-tRNA synthetase (beta subunit)
TTX_1529	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TTX_1534	ENOG4105DGA	Diaminopimelate dehydrogenase
TTX_1535	ENOG4105BZA	Phosphoglycerate kinase
TTX_1538	ENOG4105C22	threonyL-tRNA synthetase
TTX_1539	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TTX_1541	ENOG4105D0M	Protease HtpX homolog
TTX_1543	ENOG4105CZA	synthase
TTX_1545	ENOG4105CND	Glycosyl transferase, family 2
TTX_1547	ENOG4105DF6	Fe-S oxidoreductase
TTX_1549	ENOG4105EM7	Selenocysteine-specific translation elongation factor
TTX_1550	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TTX_1553	ENOG41082SA	50s ribosomal protein l29
TTX_1555	ENOG4105D52	delta-aminolevulinic acid dehydratase
TTX_1558	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
TTX_1559	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
TTX_1560	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
TTX_1562	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TTX_1563	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TTX_1564	ENOG4105D44	asparaginase
TTX_1591	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TTX_1593	ENOG4107Y70	Heat shock protein
TTX_1596	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TTX_1602	ENOG4107QTZ	amino acid
TTX_1609	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
TTX_1611	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TTX_1612	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
TTX_1614	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TTX_1615	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TTX_1616	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
TTX_1622	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
TTX_1626	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
TTX_1628	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TTX_1629	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
TTX_1636	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TTX_1640	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TTX_1642	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TTX_1646	ENOG4105C3G	gtp-binding protein
TTX_1650	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TTX_1652	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTX_1653	ENOG4105CKX	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP
TTX_1660	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
TTX_1666	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
TTX_1669	ENOG4108UJD	30S ribosomal protein S9
TTX_1670	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TTX_1676	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TTX_1677	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TTX_1678	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TTX_1680	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TTX_1693	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TTX_1714	ENOG4108RCS	geranylgeranylglyceryl phosphate synthase
TTX_1717	ENOG4105ECY	inositol monophosphatase
TTX_1723	ENOG4105VG1	fes assembly suf system protein
TTX_1725	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
TTX_1727	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
TTX_1730	ENOG4105II7	pyrroline-5-carboxylate reductase
TTX_1731	ENOG4105DQ4	alcohol dehydrogenase
TTX_1740	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TTX_1742	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TTX_1744	ENOG4105CG3	alpha amylase, catalytic region
TTX_1746	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
TTX_1747	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
TTX_1748	ENOG4105E2X	shikimate dehydrogenase
TTX_1749	ENOG41084GS	Type I DHQase
TTX_1750	ENOG4107QSS	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity)
TTX_1751	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
TTX_1752	ENOG4105D49	3-dehydroquinate synthase
TTX_1754	ENOG4108HHA	Transketolase
TTX_1756	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TTX_1757	ENOG4105DQU	oxidoreductase, subunit beta
TTX_1759	ENOG4106HK8	GPR1 FUN34 yaaH family protein
TTX_1760	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TTX_1762	ENOG4107NFR	Fructose-1,6-bisphosphatase
TTX_1764	ENOG4107GFK	fumarate
TTX_1770	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
TTX_1777	ENOG4107QQG	Dehydrogenase
TTX_1778	ENOG4105EG2	ABC transporter, permease
TTX_1780	ENOG4107FKK	extracellular solute-binding protein family 1
TTX_1785	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TTX_1787	ENOG4105C26	Dehydrogenase
TTX_1797	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TTX_1801	ENOG4107SXA	Phosphorylase
TTX_1806	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TTX_1809	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TTX_1810	ENOG4106Z6D	Molecular chaperone capable of stabilizing a range of proteins (By similarity)
TTX_1815	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TTX_1817	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TTX_1820	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
TTX_1826	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TTX_1827	ENOG4105CEP	NADH dehydrogenase
TTX_1832	ENOG4105C7N	Xanthine uracil vitamin C permease
TTX_1834	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
TTX_1835	ENOG4108K7V	UPF0284 protein
TTX_1838	ENOG4108374	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
TTX_1841	ENOG4105DK0	Indole-3-glycerol phosphate synthase
TTX_1842	ENOG4105DDQ	anthranilate synthase
TTX_1843	ENOG4105CRQ	synthase (Component I)
TTX_1850	ENOG4105D1H	recombination factor protein RarA
TTX_1851	ENOG4105D1H	recombination factor protein RarA
TTX_1852	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TTX_1867	ENOG4105D9R	oxidoreductase
TTX_1877	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
TTX_1882	ENOG4108RVA	ribokinase
TTX_1883	ENOG4107TRG	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair (By similarity)
TTX_1889	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TTX_1890	ENOG4105C8N	cysteinyl-tRNA synthetase
TTX_1894	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TTX_1896	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
TTX_1897	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
TTX_1898	ENOG4105CE9	30S ribosomal protein S2
TTX_1902	ENOG4105D1F	ATP-binding protein
TTX_1905	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
TTX_1906	ENOG4105CHR	reductase
TTX_1908	ENOG4105KG3	cytidine deaminase
TTX_1910	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TTX_1912	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TTX_1913	ENOG4105D9P	serine threonine protein kinase
TTX_1914	ENOG4105HZM	Fha domain containing protein
TTX_1917	ENOG4105CQ2	DNA polymerase
TTX_1922	ENOG4105CY0	Metallo-Beta-Lactamase
TTX_1923	ENOG4105KPK	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation (By similarity)
TTX_1924	ENOG4108YZY	peptidylprolyl cis-trans isomerase
TTX_1926	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TTX_1928	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
TTX_1934	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TTX_1937	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TTX_1943	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TTX_1950	ENOG4105DVY	radical SAM domain protein
TTX_1951	ENOG4105DVY	radical SAM domain protein
TTX_1952	ENOG4105CD3	dihydroorotase
TTX_1960	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
TTX_1962	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
TTX_1964	ENOG4105C12	Phosphoribosylglycinamide synthetase
TTX_1966	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TTX_1967	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
TTX_1969	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
TTX_1970	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TTX_1971	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
TTX_1984	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
TTX_1986	ENOG4105BZJ	Electron transfer flavoprotein
TTX_1987	ENOG4105BZ8	glutamate synthase
TTX_1988	ENOG4107RB4	Cytidine monophosphate kinase
TTX_1990	ENOG4105DIK	(ABC) transporter
TTX_1991	ENOG4108I9K	permease protein
TTX_1994	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TTX_2005	ENOG4105D0M	Protease HtpX homolog
TTX_2007	ENOG4105D6E	homoserine dehydrogenase
TTX_2009	ENOG4107QK3	aspartate-semialdehyde dehydrogenase (EC 1.2.1.11
TTX_2010	ENOG4105CFH	Aspartokinase
TTX_2012	ENOG4105D07	Signal peptide peptidase, SppA
TTX_2013	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
TTX_2015	ENOG4105CD5	CoA-binding domain protein
TTX_2016	ENOG4105CD5	CoA-binding domain protein
TTX_2024	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TTX_2025	ENOG4105C1V	Peptidase, M16
TTX_2033	ENOG4105DDK	oxidoreductase, beta subunit
TTX_2034	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
TTX_2035	ENOG4105WGB	oxidoreductase, delta subunit
TTX_2036	ENOG4105EJ5	oxidoreductase gamma subunit
TTX_2040	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TTX_2047	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
TTX_2050	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TTX_2052	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
TTX_2058	ENOG4107QKV	phosphomannomutase
TTX_2060	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
TTX_2061	ENOG4105E3H	phosphoglycerate mutase
TTX_2072	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TTX_2075	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TTX_2076	ENOG4105D06	uba thif-type nad fad binding protein
TTX_2088	ENOG4108784	2'-5' rna ligase
TTX_2092	ENOG4107STF	Involved in phosphonate degradation (By similarity)
TTX_2093	ENOG4108JQ1	Dehydrogenase
TTX_2094	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TTX_2096	ENOG4105C28	cystathionine
TTX_2108	ENOG4105EPU	Molybdenum cofactor synthesis domain protein