locus-tag	class	description
TTX_0003	COG0589	response to stress
TTX_0005	COG0154	amidase activity
TTX_0012	COG0051	transcription antitermination factor activity, RNA binding
TTX_0013	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTX_0014	COG0251	oxidation-reduction process
TTX_0025	COG0300	oxidoreductase activity
TTX_0025a	COG0697	spore germination
TTX_0034	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TTX_0038	COG0693	protein deglycase activity
TTX_0039	COG0189	ligase activity
TTX_0040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TTX_0046	COG0243	molybdopterin cofactor binding
TTX_0047	COG0437	4 iron, 4 sulfur cluster binding
TTX_0051	COG1234	tRNA 3'-trailer cleavage
TTX_0052	COG3842	ATPase activity
TTX_0065	COG1122	ATPase activity
TTX_0066	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TTX_0068	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTX_0069	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTX_0073	COG0243	molybdopterin cofactor binding
TTX_0074	COG0437	4 iron, 4 sulfur cluster binding
TTX_0083	COG0747	negative chemotaxis
TTX_0085	COG0601	transmembrane transport
TTX_0086	COG0444	Belongs to the ABC transporter superfamily
TTX_0090	COG0667	Aldo Keto reductase
TTX_0091	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTX_0093	COG0537	adenosine 5'-monophosphoramidase activity
TTX_0096	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TTX_0104	COG1028	Short-chain dehydrogenase reductase Sdr
TTX_0106	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TTX_0110	COG1966	Carbon starvation protein
TTX_0112	COG0003	Pfam Anion-transporting ATPase
TTX_0113	COG0003	Pfam Anion-transporting ATPase
TTX_0118	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTX_0120	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TTX_0121	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TTX_0123	COG0137	argininosuccinate synthase activity
TTX_0126	COG0473	3-isopropylmalate dehydrogenase activity
TTX_0128	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTX_0129	COG0066	3-isopropylmalate dehydratase activity
TTX_0130	COG0028	Belongs to the TPP enzyme family
TTX_0132	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TTX_0133	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TTX_0134	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTX_0136	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTX_0137	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TTX_0139	COG4670	ketone body catabolic process
TTX_0142	COG1271	oxidase subunit
TTX_0145	COG0450	alkyl hydroperoxide reductase
TTX_0156	COG4174	ABC transporter (Permease)
TTX_0158	COG0444	Belongs to the ABC transporter superfamily
TTX_0163	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTX_0168	COG0417	DNA replication proofreading
TTX_0174	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTX_0182	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTX_0183	COG0644	oxidoreductase
TTX_0184	COG0235	Class ii aldolase
TTX_0190	COG3842	ATPase activity
TTX_0193	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TTX_0194	COG1122	ATPase activity
TTX_0197	COG0310	cobalt ion transport
TTX_0198	COG0864	Transcriptional regulator
TTX_0200	COG0489	protein tyrosine kinase activity
TTX_0202	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TTX_0205	COG0651	ATP synthesis coupled electron transport
TTX_0206	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTX_0206	COG2111	Na H antiporter
TTX_0207	COG1007	ATP synthesis coupled electron transport
TTX_0208	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTX_0209	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTX_0210	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTX_0211	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTX_0214	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTX_0215	COG0649	NAD binding
TTX_0217	COG0438	transferase activity, transferring glycosyl groups
TTX_0220	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TTX_0227	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TTX_0230	COG1401	restriction endodeoxyribonuclease activity
TTX_0242	COG0758	DNA mediated transformation
TTX_0242	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTX_0250	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTX_0255	COG1120	ATPase activity
TTX_0256	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TTX_0264	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TTX_0277	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTX_0281	COG0714	Associated with various cellular activities
TTX_0285	COG2271	Major facilitator Superfamily
TTX_0287	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TTX_0288	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TTX_0289	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TTX_0291	COG0602	queuosine metabolic process
TTX_0293	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TTX_0294	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TTX_0296	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TTX_0297	COG0312	modulator of DNA gyrase
TTX_0298	COG0312	modulator of DNA gyrase
TTX_0298a	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TTX_0300	COG0367	asparagine synthase
TTX_0304	COG2255	four-way junction helicase activity
TTX_0307	COG1881	PFAM PEBP family protein
TTX_0311	COG0434	BtpA family
TTX_0317	COG1024	Enoyl-CoA hydratase
TTX_0325	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TTX_0326	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TTX_0329	COG1063	alcohol dehydrogenase
TTX_0330	COG3511	phospholipase C
TTX_0340	COG2890	protein-(glutamine-N5) methyltransferase activity
TTX_0352	COG1435	thymidine kinase activity
TTX_0353	COG0667	Aldo Keto reductase
TTX_0356	COG2050	protein possibly involved in aromatic compounds catabolism
TTX_0361	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TTX_0374	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TTX_0383	COG1131	(ABC) transporter
TTX_0389	COG1137	ATPase activity
TTX_0390	COG0411	ABC transporter
TTX_0399	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
TTX_0407	COG1254	Belongs to the acylphosphatase family
TTX_0408	COG0425	Belongs to the sulfur carrier protein TusA family
TTX_0410	COG2210	Belongs to the sulfur carrier protein TusA family
TTX_0414	COG0425	Belongs to the sulfur carrier protein TusA family
TTX_0415	COG2920	part of a sulfur-relay system
TTX_0423	COG2221	Nitrite and sulphite reductase 4Fe-4S
TTX_0424	COG2221	Nitrite and sulphite reductase 4Fe-4S
TTX_0427	COG2221	Nitrite and sulphite reductase 4Fe-4S
TTX_0441	COG2046	Belongs to the sulfate adenylyltransferase family
TTX_0443	COG2217	Heavy metal translocating P-type atpase
TTX_0455	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TTX_0459	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TTX_0462	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TTX_0466	COG0189	ligase activity
TTX_0467	COG0165	Argininosuccinate lyase
TTX_0472	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TTX_0474	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTX_0483	COG0559	Belongs to the binding-protein-dependent transport system permease family
TTX_0485	COG0411	ABC transporter
TTX_0486	COG0410	ABC transporter
TTX_0487	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TTX_0488	COG0667	Aldo Keto reductase
TTX_0491	COG1121	(ABC) transporter
TTX_0493	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TTX_0497	COG0372	Belongs to the citrate synthase family
TTX_0511	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TTX_0514	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTX_0523	COG0546	phosphoglycolate phosphatase activity
TTX_0534	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TTX_0535	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TTX_0540	COG3830	Belongs to the UPF0237 family
TTX_0541	COG2848	UPF0210 protein
TTX_0544	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTX_0552	COG0179	Fumarylacetoacetate (FAA) hydrolase
TTX_0556	COG0649	NAD binding
TTX_0557	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TTX_0561	COG0651	ATP synthesis coupled electron transport
TTX_0562	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTX_0563	COG1007	ATP synthesis coupled electron transport
TTX_0564	COG0105	UTP biosynthetic process
TTX_0565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTX_0570	COG1960	acyl-CoA dehydrogenase activity
TTX_0574	COG0243	molybdopterin cofactor binding
TTX_0588	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TTX_0592	COG0501	Belongs to the peptidase M48B family
TTX_0596	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TTX_0610	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TTX_0612	COG1607	acyl-coa hydrolase
TTX_0613	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TTX_0620	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TTX_0620	COG0301	tRNA thio-modification
TTX_0621	COG1881	PFAM PEBP family protein
TTX_0623	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TTX_0624	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTX_0624	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTX_0625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTX_0627	COG0174	glutamine synthetase
TTX_0628	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TTX_0628	COG0069	glutamate synthase activity
TTX_0630	COG1695	Transcriptional regulator
TTX_0634	COG2920	part of a sulfur-relay system
TTX_0635	COG2427	Protein of unknown function (DUF1641)
TTX_0637	COG0069	glutamate synthase activity
TTX_0639	COG2210	Belongs to the sulfur carrier protein TusA family
TTX_0641	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TTX_0644	COG1489	DNA binding
TTX_0650	COG2226	methyltransferase
TTX_0651	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TTX_0654	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTX_0655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTX_0656	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TTX_0657	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTX_0657	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTX_0677	COG0717	Belongs to the dCTP deaminase family
TTX_0683	COG0574	Belongs to the PEP-utilizing enzyme family
TTX_0683	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTX_0686	COG0442	prolyl-tRNA aminoacylation
TTX_0690	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TTX_0691	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TTX_0692	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TTX_0707	COG2860	membrane
TTX_0710	COG1121	(ABC) transporter
TTX_0719	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TTX_0730	COG2086	electron transfer activity
TTX_0731	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
TTX_0735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TTX_0740	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TTX_0741	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TTX_0755	COG0419	ATPase involved in DNA repair
TTX_0758	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TTX_0760	COG1136	(ABC) transporter
TTX_0762	COG2409	Drug exporters of the RND superfamily
TTX_0770	COG0330	HflC and HflK could
TTX_0771	COG1394	ATPase activity, coupled to movement of substances
TTX_0776	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TTX_0777	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TTX_0778	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TTX_0779	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TTX_0780	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTX_0781	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TTX_0781a	COG0140	phosphoribosyl-ATP diphosphatase activity
TTX_0782	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TTX_0783	COG0107	imidazoleglycerol-phosphate synthase activity
TTX_0784	COG0131	Imidazoleglycerol-phosphate dehydratase
TTX_0785	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TTX_0786	COG0519	Catalyzes the synthesis of GMP from XMP
TTX_0786	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TTX_0787	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TTX_0788	COG2379	hydroxypyruvate reductase
TTX_0789	COG0129	dihydroxy-acid dehydratase activity
TTX_0792	COG1028	Short-chain dehydrogenase reductase Sdr
TTX_0793	COG0477	Major facilitator Superfamily
TTX_0794	COG0277	FAD linked oxidase domain protein
TTX_0796	COG0167	dihydroorotate dehydrogenase activity
TTX_0798	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TTX_0798	COG0284	orotidine-5'-phosphate decarboxylase activity
TTX_0799	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TTX_0801	COG0540	Belongs to the ATCase OTCase family
TTX_0808	COG0124	histidyl-tRNA synthetase
TTX_0820	COG1185	polyribonucleotide nucleotidyltransferase activity
TTX_0821	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TTX_0828	COG0556	nucleotide-excision repair
TTX_0831	COG0656	L-ascorbic acid biosynthetic process
TTX_0833	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TTX_0837	COG1063	alcohol dehydrogenase
TTX_0839	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTX_0845	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TTX_0851	COG1201	RNA secondary structure unwinding
TTX_0855	COG3842	ATPase activity
TTX_0857	COG0351	phosphomethylpyrimidine kinase
TTX_0858	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TTX_0860	COG0494	nUDIX hydrolase
TTX_0880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTX_0883	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TTX_0886	COG0183	Belongs to the thiolase family
TTX_0895	COG4962	Type ii secretion system protein e
TTX_0902	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TTX_0907	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TTX_0910	COG0574	Belongs to the PEP-utilizing enzyme family
TTX_0910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTX_0911	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TTX_0920	COG1914	H( )-stimulated, divalent metal cation uptake system
TTX_0922	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TTX_0923	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TTX_0924	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TTX_0925	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTX_0927	COG0735	belongs to the Fur family
TTX_0929	COG0513	Belongs to the DEAD box helicase family
TTX_0932	COG0037	tRNA processing
TTX_0934	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TTX_0944	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TTX_0949	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TTX_0953	COG0017	Asparaginyl-tRNA synthetase
TTX_0957	COG0494	nUDIX hydrolase
TTX_0958	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TTX_0974	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TTX_0976	COG0308	aminopeptidase N
TTX_0977	COG1702	phosphate starvation-inducible protein PhoH
TTX_0978	COG1254	Belongs to the acylphosphatase family
TTX_0980	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TTX_0986	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TTX_0994	COG0175	sulfate reduction
TTX_0995	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TTX_0999	COG1618	nucleotide phosphatase activity, acting on free nucleotides
TTX_1000	COG0017	Asparaginyl-tRNA synthetase
TTX_1003	COG0009	L-threonylcarbamoyladenylate synthase
TTX_1005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTX_1010	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTX_1011	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTX_1016	COG0494	nUDIX hydrolase
TTX_1021	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TTX_1023	COG0183	Belongs to the thiolase family
TTX_1024	COG1960	acyl-CoA dehydrogenase activity
TTX_1025	COG0318	PFAM AMP-dependent synthetase and ligase
TTX_1026	COG0318	PFAM AMP-dependent synthetase and ligase
TTX_1027	COG1363	Peptidase, m42
TTX_1028	COG1024	Enoyl-CoA hydratase
TTX_1029	COG0183	Belongs to the thiolase family
TTX_1041	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TTX_1047	COG0163	prenyltransferase activity
TTX_1050	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TTX_1058	COG0495	leucyl-tRNA aminoacylation
TTX_1059	COG0805	protein transport
TTX_1062	COG1131	(ABC) transporter
TTX_1071	COG2255	four-way junction helicase activity
TTX_1072	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TTX_1074a	COG1254	Belongs to the acylphosphatase family
TTX_1075	COG3842	ATPase activity
TTX_1078	COG0577	efflux transmembrane transporter activity
TTX_1079	COG0644	oxidoreductase
TTX_1082	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TTX_1083	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TTX_1087	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TTX_1088	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TTX_1091	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TTX_1092	COG2264	protein methyltransferase activity
TTX_1094	COG2875	Belongs to the precorrin methyltransferase family
TTX_1095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTX_1100	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTX_1101	COG1012	belongs to the aldehyde dehydrogenase family
TTX_1104	COG1053	succinate dehydrogenase
TTX_1106	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TTX_1108	COG0516	GMP reductase activity
TTX_1108	COG0517	IMP dehydrogenase activity
TTX_1109	COG0516	GMP reductase activity
TTX_1109	COG0517	IMP dehydrogenase activity
TTX_1113	COG1960	acyl-CoA dehydrogenase activity
TTX_1114	COG1960	acyl-CoA dehydrogenase activity
TTX_1117	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTX_1124	COG0477	Major facilitator Superfamily
TTX_1126	COG0477	Major facilitator Superfamily
TTX_1127	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTX_1128	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TTX_1139	COG0517	IMP dehydrogenase activity
TTX_1139	COG0516	GMP reductase activity
TTX_1141	COG0559	Belongs to the binding-protein-dependent transport system permease family
TTX_1147	COG0303	'Molybdopterin
TTX_1154	COG1522	sequence-specific DNA binding
TTX_1156	COG4948	Mandelate Racemase Muconate Lactonizing
TTX_1156a	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TTX_1159	COG1968	undecaprenyl-diphosphatase activity
TTX_1164	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTX_1176	COG1328	CTP reductase activity
TTX_1185	COG2920	part of a sulfur-relay system
TTX_1187	COG2221	Nitrite and sulphite reductase 4Fe-4S
TTX_1197	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TTX_1198	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTX_1199	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TTX_1202	COG0437	4 iron, 4 sulfur cluster binding
TTX_1203	COG0243	molybdopterin cofactor binding
TTX_1203	COG3383	formate dehydrogenase (NAD+) activity
TTX_1209	COG0419	ATPase involved in DNA repair
TTX_1217	COG0456	acetyltransferase
TTX_1263	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TTX_1268	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTX_1269	COG3383	formate dehydrogenase (NAD+) activity
TTX_1270	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTX_1271	COG2855	membrane
TTX_1278	COG1830	Aldolase
TTX_1279	COG3276	selenocysteine insertion sequence binding
TTX_1281	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTX_1283	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTX_1285	COG0004	ammonium transporteR
TTX_1288	COG0004	ammonium transporteR
TTX_1294	COG2414	aldehyde ferredoxin oxidoreductase
TTX_1295	COG0114	fumarate hydratase activity
TTX_1296	COG0477	Major facilitator Superfamily
TTX_1301	COG1192	Involved in chromosome partitioning
TTX_1316	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TTX_1317	COG0277	FAD linked oxidase domain protein
TTX_1321	COG1620	l-lactate permease
TTX_1322	COG1832	CoA-binding protein
TTX_1330	COG0494	nUDIX hydrolase
TTX_1334	COG1091	dTDP-4-dehydrorhamnose reductase activity
TTX_1338	COG1215	transferase activity, transferring glycosyl groups
TTX_1350	COG1215	transferase activity, transferring glycosyl groups
TTX_1358	COG0726	polysaccharide deacetylase
TTX_1359	COG0438	transferase activity, transferring glycosyl groups
TTX_1362	COG0438	transferase activity, transferring glycosyl groups
TTX_1363	COG0438	transferase activity, transferring glycosyl groups
TTX_1384	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TTX_1395	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTX_1396	COG2414	aldehyde ferredoxin oxidoreductase
TTX_1400	COG0297	glycogen (starch) synthase activity
TTX_1403	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TTX_1404	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TTX_1405	COG0135	phosphoribosylanthranilate isomerase activity
TTX_1407	COG1335	isochorismatase
TTX_1408	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TTX_1410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TTX_1424	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TTX_1426	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTX_1427	COG0039	L-malate dehydrogenase activity
TTX_1430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TTX_1433	COG1201	RNA secondary structure unwinding
TTX_1435	COG2301	Belongs to the HpcH HpaI aldolase family
TTX_1436	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TTX_1437	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTX_1438	COG0477	Major facilitator Superfamily
TTX_1444	COG0719	Fe-S assembly protein
TTX_1447	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TTX_1449	COG1199	ATP-dependent helicase activity
TTX_1450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TTX_1453	COG1444	tRNA N-acetyltransferase activity
TTX_1454	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTX_1455	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTX_1455	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTX_1457	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTX_1457	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TTX_1458	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTX_1459	COG0546	phosphoglycolate phosphatase activity
TTX_1463	COG0302	gtp cyclohydrolase
TTX_1466	COG1215	transferase activity, transferring glycosyl groups
TTX_1473	COG1867	N(2),N(2)-dimethylguanosine tRNA methyltransferase
TTX_1485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTX_1489	COG0538	isocitrate dehydrogenase activity
TTX_1495	COG2079	MmgE PrpD family protein
TTX_1496	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
TTX_1511	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TTX_1513	COG0372	Belongs to the citrate synthase family
TTX_1514	COG0281	malic enzyme
TTX_1518	COG0371	Dehydrogenase
TTX_1527	COG0072	phenylalanine-tRNA ligase activity
TTX_1529	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TTX_1534	COG1748	Saccharopine dehydrogenase
TTX_1535	COG0126	phosphoglycerate kinase activity
TTX_1538	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTX_1539	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TTX_1541	COG0501	Belongs to the peptidase M48B family
TTX_1543	COG1260	myo-inositol-1-phosphate synthase
TTX_1544	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTX_1545	COG1215	transferase activity, transferring glycosyl groups
TTX_1547	COG0247	lactate metabolic process
TTX_1547	COG2181	nitrate reductase activity
TTX_1550	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TTX_1553	COG0255	Belongs to the universal ribosomal protein uL29 family
TTX_1555	COG0113	porphobilinogen synthase activity
TTX_1557	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TTX_1558	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TTX_1559	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TTX_1560	COG0181	hydroxymethylbilane synthase activity
TTX_1563	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TTX_1591	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TTX_1593	COG0071	Belongs to the small heat shock protein (HSP20) family
TTX_1596	COG0423	glycine-tRNA ligase activity
TTX_1602	COG0531	amino acid
TTX_1609	COG0584	glycerophosphoryl diester phosphodiesterase
TTX_1611	COG0303	'Molybdopterin
TTX_1612	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TTX_1614	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTX_1615	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TTX_1616	COG1234	tRNA 3'-trailer cleavage
TTX_1622	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TTX_1626	COG0585	pseudouridine synthase activity
TTX_1628	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TTX_1629	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TTX_1636	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TTX_1640	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TTX_1642	COG0528	UMP kinase activity
TTX_1646	COG0012	GTP binding
TTX_1650	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TTX_1652	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTX_1653	COG0430	RNA-3'-phosphate cyclase activity
TTX_1666	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
TTX_1669	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TTX_1670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TTX_1676	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TTX_1677	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TTX_1678	COG0085	RNA polymerase activity
TTX_1680	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TTX_1693	COG1573	uracil-dna glycosylase
TTX_1711	COG0459	protein refolding
TTX_1714	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
TTX_1717	COG0483	inositol monophosphate 1-phosphatase activity
TTX_1723	COG2151	metal-sulfur cluster biosynthetic enzyme
TTX_1725	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TTX_1727	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TTX_1730	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TTX_1731	COG1064	alcohol dehydrogenase
TTX_1742	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TTX_1746	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TTX_1747	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TTX_1748	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TTX_1749	COG0710	3-dehydroquinate dehydratase activity
TTX_1750	COG0436	Aminotransferase
TTX_1751	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TTX_1752	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TTX_1753	COG3958	Transketolase
TTX_1754	COG3959	Transketolase, thiamine diphosphate binding domain
TTX_1756	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTX_1757	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTX_1759	COG1584	GPR1 FUN34 yaaH family protein
TTX_1760	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTX_1762	COG1980	fructose-bisphosphate aldolase activity
TTX_1770	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TTX_1777	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
TTX_1778	COG3833	ABC-type maltose transport systems, permease component
TTX_1779	COG1175	transmembrane transport
TTX_1780	COG2182	Extracellular solute-binding protein
TTX_1785	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTX_1787	COG1012	belongs to the aldehyde dehydrogenase family
TTX_1797	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTX_1806	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TTX_1809	COG0552	protein localization to endoplasmic reticulum
TTX_1810	COG1730	sister chromatid segregation
TTX_1815	COG0504	CTP synthase activity
TTX_1817	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TTX_1820	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TTX_1827	COG1252	NADH dehydrogenase
TTX_1832	COG2252	PERMEase
TTX_1834	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TTX_1835	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
TTX_1838	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TTX_1841	COG0134	indole-3-glycerol-phosphate synthase activity
TTX_1842	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TTX_1842	COG0512	Glutamine amidotransferase of anthranilate synthase
TTX_1843	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TTX_1850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTX_1851	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTX_1852	COG0049	tRNA binding
TTX_1867	COG0673	inositol 2-dehydrogenase activity
TTX_1868	COG1546	Belongs to the CinA family
TTX_1868	COG1058	Belongs to the CinA family
TTX_1877	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TTX_1880	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TTX_1882	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TTX_1883	COG1793	dna ligase
TTX_1889	COG0148	phosphopyruvate hydratase activity
TTX_1890	COG0215	cysteine-tRNA ligase activity
TTX_1894	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TTX_1896	COG1304	FMN binding
TTX_1897	COG1355	regulation of microtubule-based process
TTX_1898	COG0052	Belongs to the universal ribosomal protein uS2 family
TTX_1902	COG0489	protein tyrosine kinase activity
TTX_1905	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TTX_1906	COG1028	Short-chain dehydrogenase reductase Sdr
TTX_1908	COG0295	cytidine deaminase activity
TTX_1910	COG0315	cyclic pyranopterin monophosphate synthase activity
TTX_1912	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TTX_1913	COG2815	serine threonine protein kinase
TTX_1913	COG0515	serine threonine protein kinase
TTX_1914	COG1716	ATPase activity
TTX_1917	COG0417	DNA replication proofreading
TTX_1922	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TTX_1923	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
TTX_1924	COG1047	Peptidyl-prolyl cis-trans
TTX_1926	COG0459	protein refolding
TTX_1928	COG4133	protoheme IX ABC transporter activity
TTX_1934	COG0343	queuine tRNA-ribosyltransferase activity
TTX_1937	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TTX_1942	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTX_1943	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TTX_1950	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTX_1951	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTX_1952	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TTX_1960	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TTX_1964	COG0151	Belongs to the GarS family
TTX_1966	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TTX_1967	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TTX_1969	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TTX_1970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TTX_1971	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TTX_1984	COG1110	DNA topoisomerase II activity
TTX_1986	COG2086	electron transfer activity
TTX_1987	COG0493	'glutamate synthase
TTX_1988	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TTX_1990	COG1121	(ABC) transporter
TTX_1991	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TTX_1994	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TTX_2005	COG0501	Belongs to the peptidase M48B family
TTX_2007	COG0460	homoserine dehydrogenase
TTX_2008	COG0475	glutathione-regulated potassium exporter activity
TTX_2010	COG0527	aspartate kinase activity
TTX_2011	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TTX_2012	COG0616	signal peptide processing
TTX_2013	COG2095	MarC family integral membrane protein
TTX_2015	COG0045	succinate-CoA ligase (ADP-forming) activity
TTX_2015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TTX_2015	COG1042	CoA-binding domain protein
TTX_2016	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TTX_2016	COG1042	CoA-binding domain protein
TTX_2016	COG0045	succinate-CoA ligase (ADP-forming) activity
TTX_2024	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TTX_2024	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TTX_2025	COG0612	Peptidase, M16
TTX_2033	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTX_2034	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTX_2035	COG1144	Oxidoreductase
TTX_2036	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTX_2040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TTX_2047	COG1418	mRNA catabolic process
TTX_2050	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TTX_2052	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTX_2058	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTX_2060	COG0456	acetyltransferase
TTX_2061	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TTX_2075	COG1136	(ABC) transporter
TTX_2076	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TTX_2088	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TTX_2093	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTX_2094	COG0516	GMP reductase activity
TTX_2094	COG0517	IMP dehydrogenase activity
TTX_2096	COG0626	cystathionine gamma-synthase activity