locus-tag	class	description
Toce_0002	COG0592	DNA-directed DNA polymerase activity
Toce_0004	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Toce_0007	COG0187	DNA topoisomerase II activity
Toce_0008	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Toce_0010	COG1982	Orn Lys Arg decarboxylase major
Toce_0011	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Toce_0012	COG3870	Protein conserved in bacteria
Toce_0014	COG0470	DNA polymerase III
Toce_0015	COG1774	PSP1 C-terminal conserved region
Toce_0016	COG2738	Putative neutral zinc metallopeptidase
Toce_0017	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Toce_0018	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Toce_0019	COG0726	polysaccharide deacetylase
Toce_0020	COG0352	thiamine-phosphate diphosphorylase activity
Toce_0021	COG0351	phosphomethylpyrimidine kinase
Toce_0021	COG0352	thiamine-phosphate diphosphorylase activity
Toce_0023	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Toce_0024	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Toce_0025	COG2002	toxin-antitoxin pair type II binding
Toce_0028	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Toce_0028	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Toce_0029	COG0084	hydrolase, TatD family'
Toce_0031	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Toce_0032	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Toce_0035	COG2385	sporulation resulting in formation of a cellular spore
Toce_0036	COG4466	Protein conserved in bacteria
Toce_0043	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Toce_0044	COG1802	Transcriptional regulator
Toce_0046	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Toce_0047	COG2088	sporulation resulting in formation of a cellular spore
Toce_0048	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Toce_0050	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Toce_0051	COG0193	aminoacyl-tRNA hydrolase activity
Toce_0054	COG3711	transcriptional antiterminator
Toce_0055	COG0246	Mannitol dehydrogenase
Toce_0059	COG1396	sequence-specific DNA binding
Toce_0060	COG3118	belongs to the thioredoxin family
Toce_0061	COG0803	Belongs to the bacterial solute-binding protein 9 family
Toce_0062	COG1121	(ABC) transporter
Toce_0063	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Toce_0066	COG2302	S4 RNA-binding domain
Toce_0074	COG1518	maintenance of DNA repeat elements
Toce_0075	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Toce_0084	COG2391	methyltransferase activity
Toce_0088	COG0398	Pfam SNARE associated Golgi protein
Toce_0090	COG4134	Bacterial extracellular solute-binding protein
Toce_0091	COG1178	ABC-type Fe3 transport system permease component
Toce_0093	COG3842	ATPase activity
Toce_0099	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Toce_0100	COG2002	toxin-antitoxin pair type II binding
Toce_0101	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Toce_0102	COG2244	polysaccharide biosynthetic process
Toce_0103	COG3956	TIGRFAM MazG family protein
Toce_0105	COG2385	sporulation resulting in formation of a cellular spore
Toce_0109	COG1098	S1 RNA binding domain
Toce_0113	COG1358	cellular component organization or biogenesis
Toce_0114	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Toce_0115	COG0049	tRNA binding
Toce_0116	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Toce_0117	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Toce_0118	COG0051	transcription antitermination factor activity, RNA binding
Toce_0119	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Toce_0120	COG0088	Forms part of the polypeptide exit tunnel
Toce_0121	COG0089	rRNA binding
Toce_0122	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Toce_0124	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Toce_0125	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Toce_0126	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Toce_0127	COG0255	Belongs to the universal ribosomal protein uL29 family
Toce_0128	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Toce_0130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Toce_0131	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Toce_0132	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Toce_0133	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Toce_0134	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Toce_0135	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Toce_0136	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Toce_0137	COG0200	Binds to the 23S rRNA
Toce_0138	COG0201	protein transport
Toce_0139	COG0563	adenylate kinase activity
Toce_0140	COG0024	Methionine aminopeptidase
Toce_0142	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Toce_0143	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Toce_0144	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Toce_0145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Toce_0146	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Toce_0148	COG0203	ribosomal protein L17
Toce_0149	COG1122	ATPase activity
Toce_0150	COG1122	ATPase activity
Toce_0151	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Toce_0153	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Toce_0154	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Toce_0156	COG0137	argininosuccinate synthase activity
Toce_0157	COG0165	Argininosuccinate lyase
Toce_0158	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Toce_0160	COG1114	Component of the transport system for branched-chain amino acids
Toce_0161	COG1114	Component of the transport system for branched-chain amino acids
Toce_0164	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Toce_0169	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Toce_0173	COG0709	Synthesizes selenophosphate from selenide and ATP
Toce_0176	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Toce_0181	COG3069	C4-dicarboxylate transmembrane transporter activity
Toce_0183	COG0640	Transcriptional regulator
Toce_0190	COG2801	Transposase and inactivated derivatives
Toce_0195	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Toce_0196	COG1238	metal cluster binding
Toce_0199	COG2204	response regulator
Toce_0200	COG5002	protein histidine kinase activity
Toce_0201	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Toce_0203	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Toce_0204	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Toce_0205	COG1966	Carbon starvation protein
Toce_0207	COG3275	phosphorelay sensor kinase activity
Toce_0208	COG3279	Response regulator of the LytR AlgR family
Toce_0210	COG1181	Belongs to the D-alanine--D-alanine ligase family
Toce_0214	COG1454	alcohol dehydrogenase
Toce_0215	COG0426	domain, Protein
Toce_0217	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Toce_0218	COG1773	rubredoxin
Toce_0221	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Toce_0225	COG1125	glycine betaine transport
Toce_0225	COG0517	IMP dehydrogenase activity
Toce_0226	COG1174	glycine betaine transport
Toce_0235	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Toce_0236	COG5505	Protein of unknown function (DUF819)
Toce_0240	COG1132	(ABC) transporter
Toce_0246	COG1924	4 iron, 4 sulfur cluster binding
Toce_0247	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
Toce_0248	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Toce_0249	COG1793	dna ligase
Toce_0250	COG1793	dna ligase
Toce_0250	COG3285	dna ligase
Toce_0252	COG1716	ATPase activity
Toce_0254	COG0768	penicillin binding
Toce_0256	COG1131	(ABC) transporter
Toce_0258	COG1902	pentaerythritol trinitrate reductase activity
Toce_0259	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Toce_0260	COG0180	Tryptophanyl-tRNA synthetase
Toce_0264	COG3711	transcriptional antiterminator
Toce_0264	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Toce_0265	COG1447	Phosphotransferase system cellobiose-specific component IIA
Toce_0266	COG1446	asparaginase
Toce_0267	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Toce_0270	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Toce_0272	COG0303	'Molybdopterin
Toce_0274	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Toce_0275	COG0315	cyclic pyranopterin monophosphate synthase activity
Toce_0276	COG0521	Mo-molybdopterin cofactor biosynthetic process
Toce_0278	COG0459	protein refolding
Toce_0285	COG0745	RESPONSE REGULATOR receiver
Toce_0286	COG5002	protein histidine kinase activity
Toce_0288	COG2348	transferase activity, transferring amino-acyl groups
Toce_0289	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Toce_0292	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Toce_0292	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Toce_0293	COG1063	alcohol dehydrogenase
Toce_0300	COG3716	PTS system mannose fructose sorbose family IID component
Toce_0301	COG2045	Belongs to the ComB family
Toce_0304	COG0310	cobalt ion transport
Toce_0307	COG1122	ATPase activity
Toce_0308	COG1797	cobyrinic acid a,c-diamide synthase activity
Toce_0315	COG2875	Belongs to the precorrin methyltransferase family
Toce_0319	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Toce_0320	COG0181	hydroxymethylbilane synthase activity
Toce_0321	COG1587	Uroporphyrinogen-III synthase
Toce_0321	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Toce_0322	COG0113	porphobilinogen synthase activity
Toce_0323	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Toce_0324	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Toce_0324	COG0723	plastoquinol--plastocyanin reductase activity
Toce_0327	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Toce_0328	COG0697	spore germination
Toce_0335	COG1151	hydroxylamine reductase activity
Toce_0336	COG1959	2 iron, 2 sulfur cluster binding
Toce_0337	COG1737	Transcriptional regulator
Toce_0338	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Toce_0339	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Toce_0340	COG1447	Phosphotransferase system cellobiose-specific component IIA
Toce_0342	COG2971	BadF BadG BcrA BcrD
Toce_0343	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Toce_0344	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Toce_0345	COG1486	melibiose metabolic process
Toce_0346	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
Toce_0346	COG0456	acetyltransferase
Toce_0352	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Toce_0353	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Toce_0353	COG0519	Catalyzes the synthesis of GMP from XMP
Toce_0354	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Toce_0355	COG0573	inorganic phosphate transmembrane transporter activity
Toce_0356	COG0581	inorganic phosphate transmembrane transporter activity
Toce_0357	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Toce_0358	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Toce_0359	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Toce_0360	COG1980	fructose-bisphosphate aldolase activity
Toce_0361	COG0733	neurotransmitter:sodium symporter activity
Toce_0363	COG0010	Belongs to the arginase family
Toce_0364	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Toce_0365	COG0235	Class ii aldolase
Toce_0372	COG0745	RESPONSE REGULATOR receiver
Toce_0372	COG3706	GGDEF domain
Toce_0373	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Toce_0375	COG1546	Belongs to the CinA family
Toce_0375	COG1058	Belongs to the CinA family
Toce_0377	COG4569	acetaldehyde dehydrogenase (acetylating) activity
Toce_0378	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Toce_0383	COG2414	aldehyde ferredoxin oxidoreductase
Toce_0385	COG1414	Transcriptional regulator
Toce_0386	COG1606	tRNA processing
Toce_0387	COG1691	(AIR) carboxylase
Toce_0388	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
Toce_0389	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Toce_0391	COG1725	Transcriptional regulator
Toce_0395	COG1131	(ABC) transporter
Toce_0396	COG1725	Transcriptional regulator
Toce_0400	COG1396	sequence-specific DNA binding
Toce_0432	COG0739	heme binding
Toce_0444	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Toce_0445	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Toce_0449	COG1492	cobalamin metabolic process
Toce_0451	COG1013	pyruvate-flavodoxin oxidoreductase activity
Toce_0452	COG0674	pyruvate-flavodoxin oxidoreductase activity
Toce_0453	COG1144	Oxidoreductase
Toce_0453	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Toce_0454	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Toce_0459	COG5002	protein histidine kinase activity
Toce_0460	COG0784	Response regulator, receiver
Toce_0461	COG0786	glutamate:sodium symporter activity
Toce_0462	COG0170	dolichyl monophosphate biosynthetic process
Toce_0463	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Toce_0465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Toce_0466	COG1181	Belongs to the D-alanine--D-alanine ligase family
Toce_0468	COG0840	transmembrane signaling receptor activity
Toce_0469	COG0840	transmembrane signaling receptor activity
Toce_0470	COG0835	chemotaxis
Toce_0472	COG2201	protein-glutamate methylesterase activity
Toce_0479	COG0585	pseudouridine synthase activity
Toce_0480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Toce_0485	COG1404	Belongs to the peptidase S8 family
Toce_0491	COG1216	Glycosyl transferase, family 2
Toce_0492	COG1215	transferase activity, transferring glycosyl groups
Toce_0493	COG0438	transferase activity, transferring glycosyl groups
Toce_0494	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Toce_0500	COG0489	protein tyrosine kinase activity
Toce_0502	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Toce_0503	COG0438	transferase activity, transferring glycosyl groups
Toce_0504	COG0297	glycogen (starch) synthase activity
Toce_0505	COG0438	transferase activity, transferring glycosyl groups
Toce_0509	COG0297	glycogen (starch) synthase activity
Toce_0510	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Toce_0511	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Toce_0512	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Toce_0515	COG0371	Dehydrogenase
Toce_0518	COG0632	four-way junction helicase activity
Toce_0520	COG2337	Toxic component of a toxin-antitoxin (TA) module
Toce_0524	COG1353	crispr-associated protein
Toce_0526	COG1337	RAMP superfamily
Toce_0535	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Toce_0538	COG0822	iron-sulfur transferase activity
Toce_0539	COG0383	alpha-mannosidase activity
Toce_0541	COG3711	transcriptional antiterminator
Toce_0541	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Toce_0545	COG2972	Histidine kinase
Toce_0546	COG2201	protein-glutamate methylesterase activity
Toce_0547	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Toce_0554	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
Toce_0555	COG4869	propanediol catabolic process
Toce_0556	COG4820	ethanolamine utilization protein (EutJ)
Toce_0561	COG4656	Part of a membrane complex involved in electron transport
Toce_0570	COG0720	synthase
Toce_0571	COG1469	GTP cyclohydrolase I activity
Toce_0572	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Toce_0573	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Toce_0573	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Toce_0574	COG0726	polysaccharide deacetylase
Toce_0575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Toce_0580	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Toce_0583	COG0310	cobalt ion transport
Toce_0585	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Toce_0586	COG1122	ATPase activity
Toce_0591	COG2188	Transcriptional regulator
Toce_0592	COG0295	cytidine deaminase activity
Toce_0593	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Toce_0594	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Toce_0605	COG0367	asparagine synthase
Toce_0607	COG2226	methyltransferase
Toce_0608	COG0456	acetyltransferase
Toce_0608	COG1214	PFAM Peptidase M22, glycoprotease
Toce_0610	COG0321	lipoyl(octanoyl) transferase activity
Toce_0611	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Toce_0612	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Toce_0613	COG0747	negative chemotaxis
Toce_0617	COG0444	Belongs to the ABC transporter superfamily
Toce_0618	COG4608	Belongs to the ABC transporter superfamily
Toce_0621	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Toce_0622	COG0287	Prephenate dehydrogenase
Toce_0623	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Toce_0624	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Toce_0625	COG0527	aspartate kinase activity
Toce_0627	COG1301	dicarboxylic acid transport
Toce_0628	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Toce_0629	COG0785	Cytochrome C biogenesis protein
Toce_0634	COG3033	Beta-eliminating lyase
Toce_0635	COG0012	GTP binding
Toce_0636	COG0561	phosphatase activity
Toce_0637	COG1187	pseudouridine synthase activity
Toce_0642	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Toce_0645	COG1876	peptidase activity
Toce_0646	COG1929	Belongs to the glycerate kinase type-1 family
Toce_0647	COG2610	gluconate transmembrane transporter activity
Toce_0648	COG3835	regulator
Toce_0651	COG2721	sulfolactate sulfo-lyase activity
Toce_0654	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Toce_0656	COG0154	amidase activity
Toce_0657	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Toce_0658	COG4166	transmembrane transport
Toce_0659	COG0601	transmembrane transport
Toce_0660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Toce_0661	COG0444	Belongs to the ABC transporter superfamily
Toce_0662	COG4608	Belongs to the ABC transporter superfamily
Toce_0663	COG0037	tRNA processing
Toce_0665	COG1254	Belongs to the acylphosphatase family
Toce_0666	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Toce_0669	COG0432	Pfam Uncharacterised protein family UPF0047
Toce_0684	COG0525	valine-tRNA ligase activity
Toce_0688	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Toce_0694	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Toce_0698	COG4656	Part of a membrane complex involved in electron transport
Toce_0699	COG4658	electron transport chain
Toce_0701	COG4660	Part of a membrane complex involved in electron transport
Toce_0702	COG4657	Part of a membrane complex involved in electron transport
Toce_0703	COG1245	4Fe-4S binding domain
Toce_0703	COG2878	Part of a membrane complex involved in electron transport
Toce_0706	COG5012	cobalamin binding
Toce_0707	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Toce_0710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Toce_0711	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Toce_0712	COG0626	cystathionine gamma-synthase activity
Toce_0715	COG0785	Cytochrome C biogenesis protein
Toce_0722	COG2217	Heavy metal translocating P-type atpase
Toce_0726	COG3546	catalase activity
Toce_0730	COG2814	Major facilitator Superfamily
Toce_0731	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Toce_0732	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Toce_0733	COG1268	BioY protein
Toce_0734	COG2608	mercury ion transmembrane transporter activity
Toce_0739	COG2003	Belongs to the UPF0758 family
Toce_0740	COG1077	Cell shape determining protein MreB Mrl
Toce_0741	COG1792	Involved in formation and maintenance of cell shape
Toce_0743	COG0768	penicillin binding
Toce_0745	COG2894	cell division
Toce_0746	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Toce_0747	COG0772	Belongs to the SEDS family
Toce_0752	COG1530	ribonuclease E activity
Toce_0757	COG3409	Peptidoglycan-binding domain 1 protein
Toce_0757	COG3773	Cell wall hydrolase
Toce_0758	COG2959	enzyme of heme biosynthesis
Toce_0763	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Toce_0764	COG2868	ribosomal protein
Toce_0765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Toce_0767	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Toce_0768	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Toce_0769	COG1713	HD superfamily hydrolase involved in NAD metabolism
Toce_0770	COG1316	TRANSCRIPTIONal
Toce_0771	COG0799	negative regulation of ribosome biogenesis
Toce_0772	COG0495	leucyl-tRNA aminoacylation
Toce_0773	COG1596	polysaccharide export
Toce_0773	COG1555	photosystem II stabilization
Toce_0776	COG0534	Mate efflux family protein
Toce_0777	COG2116	formate transmembrane transporter activity
Toce_0779	COG3583	domain protein
Toce_0779	COG3584	3D domain protein
Toce_0780	COG1686	Belongs to the peptidase S11 family
Toce_0782	COG2323	membrane
Toce_0790	COG5012	cobalamin binding
Toce_0793	COG5012	cobalamin binding
Toce_0794	COG2188	Transcriptional regulator
Toce_0799	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Toce_0800	COG1151	hydroxylamine reductase activity
Toce_0804	COG3404	Formiminotransferase-cyclodeaminase
Toce_0805	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Toce_0808	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Toce_0820	COG1205	dead DEAH box helicase
Toce_0820	COG1111	helicase
Toce_0821	COG3359	exonuclease
Toce_0822	COG0423	glycine-tRNA ligase activity
Toce_0829	COG3829	transcription factor binding
Toce_0829	COG3290	protein histidine kinase activity
Toce_0830	COG0280	phosphate acetyltransferase
Toce_0832	COG3426	butyrate kinase activity
Toce_0841	COG2309	aminopeptidase activity
Toce_0843	COG2333	competence protein COMEC
Toce_0843	COG0658	competence protein
Toce_0845	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
Toce_0846	COG2222	sugar isomerase
Toce_0847	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Toce_0851	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Toce_0853	COG0123	including yeast histone deacetylase and acetoin utilization protein
Toce_0857	COG2239	Acts as a magnesium transporter
Toce_0858	COG2239	Acts as a magnesium transporter
Toce_0860	COG3679	Belongs to the UPF0342 family
Toce_0862	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Toce_0863	COG1660	Displays ATPase and GTPase activities
Toce_0864	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Toce_0865	COG1481	regulation of sporulation
Toce_0866	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Toce_0867	COG4109	DRTGG domain
Toce_0870	COG0205	6-phosphofructokinase activity
Toce_0873	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Toce_0874	COG1595	DNA-templated transcription, initiation
Toce_0876	COG1131	(ABC) transporter
Toce_0878	COG1376	ErfK ybiS ycfS ynhG family protein
Toce_0879	COG2715	membrane protein required for spore maturation
Toce_0880	COG0700	Nucleoside recognition
Toce_0881	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Toce_0883	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Toce_0883	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Toce_0889	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Toce_0895	COG2333	competence protein COMEC
Toce_0895	COG0658	competence protein
Toce_0898	COG0268	Binds directly to 16S ribosomal RNA
Toce_0900	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Toce_0903	COG0481	GTPase activity
Toce_0904	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Toce_0905	COG0564	pseudouridine synthase activity
Toce_0906	COG1420	regulation of RNA biosynthetic process
Toce_0907	COG0459	protein refolding
Toce_0909	COG0443	Heat shock 70 kDa protein
Toce_0911	COG2264	protein methyltransferase activity
Toce_0912	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Toce_0913	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Toce_0914	COG0537	adenosine 5'-monophosphoramidase activity
Toce_0915	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Toce_0919	COG1702	phosphate starvation-inducible protein PhoH
Toce_0920	COG1480	7TM receptor with intracellular HD hydrolase
Toce_0921	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Toce_0922	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Toce_0923	COG1470	cell adhesion involved in biofilm formation
Toce_0924	COG1381	Involved in DNA repair and RecF pathway recombination
Toce_0926	COG0517	IMP dehydrogenase activity
Toce_0927	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Toce_0928	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Toce_0928	COG0574	Belongs to the PEP-utilizing enzyme family
Toce_0930	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Toce_0931	COG0358	DNA primase activity
Toce_0933	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Toce_0934	COG2384	SAM-dependent methyltransferase
Toce_0935	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Toce_0941	COG0612	Peptidase, M16
Toce_0942	COG0612	Peptidase, M16
Toce_0943	COG2001	Belongs to the MraZ family
Toce_0944	COG0275	rRNA processing
Toce_0945	COG3116	cell division
Toce_0946	COG0768	penicillin binding
Toce_0948	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Toce_0949	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Toce_0950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Toce_0951	COG0772	Belongs to the SEDS family
Toce_0952	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Toce_0953	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Toce_0954	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Toce_0955	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Toce_0957	COG3856	small basic protein
Toce_0959	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Toce_0961	COG1191	sigma factor activity
Toce_0962	COG1191	sigma factor activity
Toce_0964	COG1873	PFAM PRC-barrel domain
Toce_0967	COG0745	RESPONSE REGULATOR receiver
Toce_0968	COG5002	protein histidine kinase activity
Toce_0969	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Toce_0970	COG0704	Plays a role in the regulation of phosphate uptake
Toce_0978	COG1160	GTP binding
Toce_0979	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Toce_0980	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Toce_0981	COG0500	methyltransferase
Toce_0982	COG4974	Belongs to the 'phage' integrase family
Toce_1004	COG0534	Mate efflux family protein
Toce_1006	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Toce_1007	COG1799	cell septum assembly
Toce_1009	COG3599	regulation of cell shape
Toce_1011	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Toce_1013	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Toce_1014	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Toce_1015	COG0564	pseudouridine synthase activity
Toce_1019	COG0436	Aminotransferase
Toce_1020	COG1561	YicC-like family, N-terminal region
Toce_1022	COG0194	GDP metabolic process
Toce_1023	COG1758	RNA polymerase activity
Toce_1024	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Toce_1025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Toce_1027	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Toce_1029	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Toce_1029	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Toce_1031	COG0631	protein serine/threonine phosphatase activity
Toce_1032	COG2815	serine threonine protein kinase
Toce_1032	COG0515	serine threonine protein kinase
Toce_1033	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Toce_1035	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Toce_1036	COG1302	Protein conserved in bacteria
Toce_1037	COG1461	Dihydroxyacetone kinase
Toce_1038	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Toce_1040	COG0742	ribosomal rna small subunit methyltransferase
Toce_1041	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Toce_1043	COG3314	Sporulation integral membrane protein YlbJ
Toce_1044	COG1752	Esterase of the alpha-beta hydrolase superfamily
Toce_1045	COG3480	Lon protease (S16) C-terminal proteolytic domain
Toce_1046	COG1323	Belongs to the UPF0348 family
Toce_1051	COG2030	dehydratase
Toce_1052	COG0416	fatty acid biosynthetic process
Toce_1053	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Toce_1054	COG1307	EDD domain protein, DegV family
Toce_1055	COG2070	2-Nitropropane dioxygenase
Toce_1056	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Toce_1057	COG1028	Short-chain dehydrogenase reductase Sdr
Toce_1058	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Toce_1059	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Toce_1060	COG0571	ribonuclease III activity
Toce_1061	COG2359	stage V sporulation protein S
Toce_1063	COG0552	protein localization to endoplasmic reticulum
Toce_1064	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
Toce_1065	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Toce_1066	COG0228	four-way junction DNA binding
Toce_1068	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Toce_1069	COG0336	Belongs to the RNA methyltransferase TrmD family
Toce_1070	COG0335	large ribosomal subunit rRNA binding
Toce_1071	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Toce_1072	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Toce_1073	COG0792	nuclease activity
Toce_1076	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Toce_1077	COG0534	Mate efflux family protein
Toce_1078	COG5012	cobalamin binding
Toce_1082	COG0606	chelatase, subunit chli
Toce_1083	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Toce_1084	COG0758	DNA mediated transformation
Toce_1084	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Toce_1085	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Toce_1086	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Toce_1087	COG4974	Belongs to the 'phage' integrase family
Toce_1088	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Toce_1089	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Toce_1092	COG1815	bacterial-type flagellum-dependent cell motility
Toce_1094	COG1677	Flagellar hook-basal body complex protein FliE
Toce_1095	COG1766	The M ring may be actively involved in energy transduction
Toce_1096	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Toce_1098	COG1157	protein secretion by the type III secretion system
Toce_1109	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Toce_1110	COG1776	CheC inhibitor of MCP methylation
Toce_1110	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Toce_1111	COG2201	protein-glutamate methylesterase activity
Toce_1113	COG1338	Plays a role in the flagellum-specific transport system
Toce_1114	COG1987	bacterial-type flagellum assembly
Toce_1115	COG1684	flagellar biosynthetic protein fliR
Toce_1116	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Toce_1117	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Toce_1118	COG1419	protein localization to endoplasmic reticulum
Toce_1119	COG0455	bacterial-type flagellum organization
Toce_1121	COG0643	Histidine kinase
Toce_1121	COG2198	Histidine kinase
Toce_1122	COG0835	chemotaxis
Toce_1123	COG1776	CheC inhibitor of MCP methylation
Toce_1124	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Toce_1125	COG1191	sigma factor activity
Toce_1129	COG1959	2 iron, 2 sulfur cluster binding
Toce_1131	COG0822	iron-sulfur transferase activity
Toce_1132	COG0482	sulfurtransferase activity
Toce_1136	COG0628	permease
Toce_1137	COG0019	diaminopimelate decarboxylase activity
Toce_1138	COG1994	Peptidase M50
Toce_1139	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Toce_1142	COG3874	Sporulation protein YtfJ
Toce_1144	COG1686	Belongs to the peptidase S11 family
Toce_1145	COG0445	tRNA wobble uridine modification
Toce_1145	COG0445	tRNA wobble uridine modification
Toce_1146	COG0543	2 iron, 2 sulfur cluster binding
Toce_1147	COG0445	tRNA wobble uridine modification
Toce_1147	COG0445	tRNA wobble uridine modification
Toce_1148	COG1187	pseudouridine synthase activity
Toce_1149	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Toce_1150	COG0010	Belongs to the arginase family
Toce_1151	COG1120	ATPase activity
Toce_1153	COG2081	HI0933 family
Toce_1154	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Toce_1156	COG0539	negative regulation of cytoplasmic translation
Toce_1156	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Toce_1159	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Toce_1163	COG3328	transposase activity
Toce_1164	COG1363	Peptidase, m42
Toce_1169	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Toce_1181	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Toce_1182	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
Toce_1185	COG0464	growth
Toce_1186	COG1923	regulation of RNA biosynthetic process
Toce_1188	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Toce_1190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Toce_1191	COG1573	uracil-dna glycosylase
Toce_1192	COG2720	vancomycin resistance protein
Toce_1194	COG4770	biotin carboxylase activity
Toce_1196	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Toce_1197	COG0346	lactoylglutathione lyase activity
Toce_1198	COG1703	isobutyryl-CoA mutase activity
Toce_1199	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Toce_1199	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Toce_1203	COG1013	pyruvate-flavodoxin oxidoreductase activity
Toce_1204	COG0674	pyruvate-flavodoxin oxidoreductase activity
Toce_1204	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Toce_1206	COG0587	DNA-directed DNA polymerase activity
Toce_1207	COG2359	stage V sporulation protein S
Toce_1208	COG1692	metallophosphoesterase
Toce_1215	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Toce_1216	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Toce_1218	COG1546	Belongs to the CinA family
Toce_1218	COG1058	Belongs to the CinA family
Toce_1219	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Toce_1221	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Toce_1222	COG1426	Protein conserved in bacteria
Toce_1223	COG1674	ftsk spoiiie
Toce_1225	COG0740	serine-type endopeptidase activity
Toce_1227	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Toce_1228	COG1873	PFAM PRC-barrel domain
Toce_1229	COG0756	dUTP diphosphatase activity
Toce_1230	COG0726	polysaccharide deacetylase
Toce_1231	COG1185	polyribonucleotide nucleotidyltransferase activity
Toce_1232	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Toce_1233	COG0196	riboflavin kinase activity
Toce_1234	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Toce_1235	COG2404	hydrolase activity, acting on ester bonds
Toce_1238	COG1358	cellular component organization or biogenesis
Toce_1239	COG2740	Nucleic-acid-binding protein implicated in transcription termination
Toce_1240	COG0195	Participates in both transcription termination and antitermination
Toce_1242	COG2176	DNA-directed DNA polymerase activity
Toce_1243	COG1285	pathogenesis
Toce_1244	COG0463	Glycosyl transferase, family 2
Toce_1245	COG0442	prolyl-tRNA aminoacylation
Toce_1246	COG0442	prolyl-tRNA aminoacylation
Toce_1249	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Toce_1250	COG0750	zinc metalloprotease
Toce_1251	COG0628	permease
Toce_1252	COG4589	Belongs to the CDS family
Toce_1253	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Toce_1254	COG0233	cytoplasmic translational termination
Toce_1255	COG0528	UMP kinase activity
Toce_1256	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Toce_1257	COG0052	Belongs to the universal ribosomal protein uS2 family
Toce_1258	COG1924	4 iron, 4 sulfur cluster binding
Toce_1263	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Toce_1268	COG2172	sigma factor antagonist activity
Toce_1270	COG1686	Belongs to the peptidase S11 family
Toce_1271	COG4974	Belongs to the 'phage' integrase family
Toce_1272	COG1300	Membrane
Toce_1273	COG1379	DNA repair
Toce_1274	COG0494	nUDIX hydrolase
Toce_1282	COG2369	cell adhesion
Toce_1301	COG0750	zinc metalloprotease
Toce_1302	COG0497	DNA recombination
Toce_1303	COG1438	arginine binding
Toce_1304	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Toce_1306	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Toce_1309	COG1722	exodeoxyribonuclease VII activity
Toce_1311	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Toce_1314	COG1302	Protein conserved in bacteria
Toce_1322	COG3854	ATPases associated with a variety of cellular activities
Toce_1324	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Toce_1325	COG0006	proline dipeptidase activity
Toce_1326	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Toce_1334	COG2165	general secretion pathway protein
Toce_1335	COG1459	type II secretion system
Toce_1337	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Toce_1338	COG1191	sigma factor activity
Toce_1339	COG0768	penicillin binding
Toce_1340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Toce_1343	COG0735	belongs to the Fur family
Toce_1344	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Toce_1348	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Toce_1349	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Toce_1353	COG0667	Aldo Keto reductase
Toce_1354	COG4472	Bacterial protein of unknown function (DUF965)
Toce_1355	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Toce_1357	COG1937	Protein conserved in bacteria
Toce_1358	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Toce_1359	COG0124	histidyl-tRNA synthetase
Toce_1360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Toce_1362	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Toce_1364	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Toce_1365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Toce_1366	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Toce_1366	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Toce_1370	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Toce_1371	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Toce_1374	COG1862	Preprotein translocase
Toce_1377	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Toce_1378	COG2385	sporulation resulting in formation of a cellular spore
Toce_1380	COG2255	four-way junction helicase activity
Toce_1381	COG0632	four-way junction helicase activity
Toce_1384	COG0217	transcriptional regulatory protein
Toce_1385	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Toce_1386	COG1739	Uncharacterized protein family UPF0029
Toce_1387	COG3409	Peptidoglycan-binding domain 1 protein
Toce_1387	COG3773	Cell wall hydrolase
Toce_1389	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Toce_1391	COG1683	Conserved Protein
Toce_1393	COG0826	peptidase U32
Toce_1394	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Toce_1394	COG1796	DNA polymerase
Toce_1395	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Toce_1396	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Toce_1396	COG0072	phenylalanine-tRNA ligase activity
Toce_1397	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Toce_1398	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Toce_1399	COG0569	domain protein
Toce_1400	COG0569	domain protein
Toce_1401	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Toce_1402	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Toce_1403	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Toce_1404	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Toce_1405	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Toce_1407	COG4399	Belongs to the UPF0754 family
Toce_1407	COG4399	Belongs to the UPF0754 family
Toce_1416	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Toce_1417	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Toce_1420	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Toce_1422	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Toce_1424	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Toce_1425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Toce_1426	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Toce_1427	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Toce_1429	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Toce_1430	COG0508	dehydrogenase complex catalyzes the overall conversion of
Toce_1431	COG0022	dehydrogenase e1 component
Toce_1432	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Toce_1435	COG3732	PTS system glucitol sorbitol-specific
Toce_1437	COG0459	protein refolding
Toce_1438	COG2390	Transcriptional regulator
Toce_1440	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Toce_1443	COG1063	alcohol dehydrogenase
Toce_1444	COG3775	system Galactitol-specific IIC component
Toce_1446	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Toce_1447	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Toce_1447	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Toce_1448	COG0322	excinuclease ABC activity
Toce_1450	COG1763	Mo-molybdopterin cofactor biosynthetic process
Toce_1451	COG1115	amino acid carrier protein
Toce_1453	COG0686	Belongs to the AlaDH PNT family
Toce_1454	COG5002	protein histidine kinase activity
Toce_1455	COG0745	RESPONSE REGULATOR receiver
Toce_1460	COG0704	Plays a role in the regulation of phosphate uptake
Toce_1463	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Toce_1464	COG0301	tRNA thio-modification
Toce_1465	COG1104	cysteine desulfurase activity
Toce_1469	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Toce_1473	COG1228	amidohydrolase
Toce_1475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Toce_1476	COG2986	histidine ammonia-lyase
Toce_1477	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Toce_1480	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Toce_1481	COG0583	DNA-binding transcription factor activity
Toce_1485	COG5012	cobalamin binding
Toce_1491	COG3457	Alanine racemase
Toce_1492	COG3829	transcription factor binding
Toce_1496	COG0622	Phosphoesterase
Toce_1497	COG0151	Belongs to the GarS family
Toce_1498	COG0138	bifunctional purine biosynthesis protein purh
Toce_1499	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Toce_1500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Toce_1501	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Toce_1502	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Toce_1503	COG0047	phosphoribosylformylglycinamidine synthase activity
Toce_1504	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Toce_1505	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Toce_1506	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Toce_1510	COG0436	Aminotransferase
Toce_1511	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Toce_1512	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Toce_1514	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Toce_1514	COG1796	DNA polymerase
Toce_1515	COG0778	Nitroreductase
Toce_1519	COG1309	transcriptional regulator
Toce_1520	COG0142	geranyltranstransferase activity
Toce_1527	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Toce_1528	COG0793	Belongs to the peptidase S41A family
Toce_1528	COG3409	Peptidoglycan-binding domain 1 protein
Toce_1533	COG0646	methionine synthase
Toce_1533	COG1410	methionine synthase
Toce_1535	COG1962	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit
Toce_1542	COG1366	Belongs to the anti-sigma-factor antagonist family
Toce_1550	COG0583	DNA-binding transcription factor activity
Toce_1552	COG2132	Multicopper oxidase
Toce_1553	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Toce_1555	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Toce_1562	COG0733	neurotransmitter:sodium symporter activity
Toce_1565	COG0280	phosphate acetyltransferase
Toce_1566	COG3426	butyrate kinase activity
Toce_1568	COG3829	transcription factor binding
Toce_1568	COG3290	protein histidine kinase activity
Toce_1570	COG1126	abc transporter atp-binding protein
Toce_1571	COG0765	amino acid transport
Toce_1572	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Toce_1576	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Toce_1578	COG1516	flagellar protein fliS
Toce_1579	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Toce_1584	COG3328	transposase activity
Toce_1586	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Toce_1587	COG0457	Tetratricopeptide repeat
Toce_1587	COG0463	Glycosyl transferase, family 2
Toce_1588	COG1216	Glycosyl transferase, family 2
Toce_1588	COG0463	Glycosyl transferase, family 2
Toce_1593	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Toce_1594	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Toce_1596	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Toce_1597	COG1256	bacterial-type flagellum assembly
Toce_1597	COG4786	Flagellar basal body rod
Toce_1603	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Toce_1604	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Toce_1606	COG1704	LemA family
Toce_1610	COG1971	Probably functions as a manganese efflux pump
Toce_1617	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Toce_1618	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Toce_1622	COG3118	belongs to the thioredoxin family
Toce_1627	COG0640	Transcriptional regulator
Toce_1642	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Toce_1645	COG1132	(ABC) transporter
Toce_1646	COG1132	(ABC) transporter
Toce_1649	COG0105	UTP biosynthetic process
Toce_1650	COG0352	thiamine-phosphate diphosphorylase activity
Toce_1651	COG0739	heme binding
Toce_1651	COG0741	lytic transglycosylase activity
Toce_1651	COG1196	nuclear chromosome segregation
Toce_1652	COG0237	dephospho-CoA kinase activity
Toce_1654	COG1396	sequence-specific DNA binding
Toce_1659	COG1376	ErfK ybiS ycfS ynhG family protein
Toce_1661	COG2267	carboxylic ester hydrolase activity
Toce_1662	COG1151	hydroxylamine reductase activity
Toce_1667	COG0737	Belongs to the 5'-nucleotidase family
Toce_1670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Toce_1671	COG0556	nucleotide-excision repair
Toce_1672	COG1132	(ABC) transporter
Toce_1678	COG0252	asparaginase activity
Toce_1678	COG5275	peptidyl-tyrosine sulfation
Toce_1679	COG0252	asparaginase activity
Toce_1679	COG5275	peptidyl-tyrosine sulfation
Toce_1680	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Toce_1681	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Toce_1683	COG5275	peptidyl-tyrosine sulfation
Toce_1683	COG0252	asparaginase activity
Toce_1684	COG4656	Part of a membrane complex involved in electron transport
Toce_1685	COG2204	response regulator
Toce_1687	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Toce_1688	COG3409	Peptidoglycan-binding domain 1 protein
Toce_1688	COG0793	Belongs to the peptidase S41A family
Toce_1689	COG0739	heme binding
Toce_1690	COG2177	Part of the ABC transporter FtsEX involved in
Toce_1691	COG2884	Cell division ATP-binding protein ftsE
Toce_1692	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Toce_1693	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Toce_1693	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Toce_1695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Toce_1695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Toce_1696	COG0463	Glycosyl transferase, family 2
Toce_1699	COG0789	Transcriptional regulator
Toce_1700	COG1486	melibiose metabolic process
Toce_1701	COG3958	Transketolase
Toce_1702	COG3959	Transketolase, thiamine diphosphate binding domain
Toce_1703	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Toce_1709	COG0653	protein targeting
Toce_1713	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Toce_1713	COG1918	ferrous iron import across plasma membrane
Toce_1716	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
Toce_1717	COG3859	Proton-coupled thiamine transporter YuaJ
Toce_1719	COG1527	subunit (C
Toce_1720	COG1269	ATP hydrolysis coupled proton transport
Toce_1721	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Toce_1722	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Toce_1726	COG1394	ATPase activity, coupled to movement of substances
Toce_1730	COG0142	geranyltranstransferase activity
Toce_1731	COG1252	NADH dehydrogenase
Toce_1734	COG1331	Highly conserved protein containing a thioredoxin domain
Toce_1736	COG1533	DNA photolyase activity
Toce_1737	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Toce_1740	COG4555	ABC transporter
Toce_1742	COG4753	response regulator
Toce_1742	COG2207	Transcriptional regulator
Toce_1744	COG1653	transport
Toce_1747	COG1191	sigma factor activity
Toce_1750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Toce_1757	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Toce_1759	COG4496	protein, YerC YecD
Toce_1760	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Toce_1761	COG0671	phosphoesterase, PA-phosphatase related
Toce_1763	COG1854	S-ribosylhomocysteine lyase activity
Toce_1764	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Toce_1765	COG1067	ATP-dependent peptidase activity
Toce_1765	COG0470	DNA polymerase III
Toce_1766	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Toce_1767	COG0740	serine-type endopeptidase activity
Toce_1769	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Toce_1777	COG1404	Belongs to the peptidase S8 family
Toce_1780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Toce_1782	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Toce_1783	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Toce_1784	COG5401	PFAM Sporulation and spore germination
Toce_1785	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
Toce_1786	COG0860	N-Acetylmuramoyl-L-alanine amidase
Toce_1788	COG1757	Na H antiporter
Toce_1789	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Toce_1793	COG1592	Rubrerythrin
Toce_1795	COG0860	N-Acetylmuramoyl-L-alanine amidase
Toce_1795	COG2247	cell wall binding repeat
Toce_1796	COG2814	Major facilitator Superfamily
Toce_1800	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Toce_1801	COG1760	l-serine dehydratase
Toce_1802	COG1760	l-serine dehydratase
Toce_1803	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Toce_1806	COG3842	ATPase activity
Toce_1807	COG3835	regulator
Toce_1808	COG0728	peptidoglycan biosynthetic process
Toce_1809	COG1940	carbohydrate kinase activity
Toce_1810	COG0191	fructose-bisphosphate aldolase activity
Toce_1811	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Toce_1816	COG0037	tRNA processing
Toce_1817	COG2104	thiamine diphosphate biosynthetic process
Toce_1818	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Toce_1819	COG0557	exoribonuclease II activity
Toce_1820	COG1418	mRNA catabolic process
Toce_1823	COG1592	Rubrerythrin
Toce_1827	COG0281	malic enzyme
Toce_1828	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Toce_1829	COG4770	biotin carboxylase activity
Toce_1831	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Toce_1832	COG0346	lactoylglutathione lyase activity
Toce_1833	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Toce_1833	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Toce_1836	COG0427	acetyl-CoA hydrolase
Toce_1840	COG1984	allophanate hydrolase subunit 2
Toce_1841	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Toce_1842	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Toce_1844	COG3852	Histidine kinase
Toce_1845	COG2204	response regulator
Toce_1846	COG1914	H( )-stimulated, divalent metal cation uptake system
Toce_1847	COG0598	Magnesium transport protein CorA
Toce_1848	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Toce_1849	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Toce_1850	COG0148	phosphopyruvate hydratase activity
Toce_1852	COG0149	triose-phosphate isomerase activity
Toce_1853	COG0126	phosphoglycerate kinase activity
Toce_1856	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Toce_1859	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Toce_1860	COG2033	superoxide reductase activity
Toce_1863	COG0456	acetyltransferase
Toce_1864	COG1136	(ABC) transporter
Toce_1866	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Toce_1867	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Toce_1868	COG1473	amidohydrolase
Toce_1871	COG1879	ABC-type sugar transport system periplasmic component
Toce_1872	COG1172	Belongs to the binding-protein-dependent transport system permease family
Toce_1873	COG1129	ABC transporter
Toce_1876	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Toce_1878	COG1609	Transcriptional regulator
Toce_1885	COG2252	PERMEase
Toce_1887	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Toce_1892	COG0456	acetyltransferase
Toce_1893	COG1214	PFAM Peptidase M22, glycoprotease
Toce_1894	COG0802	atpase or kinase
Toce_1895	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Toce_1896	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
Toce_1897	COG0800	Aldolase
Toce_1898	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Toce_1899	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Toce_1900	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Toce_1901	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Toce_1901	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Toce_1902	COG3716	PTS system mannose fructose sorbose family IID component
Toce_1905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Toce_1905	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Toce_1906	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Toce_1906	COG3933	PFAM sigma-54 factor interaction domain-containing protein
Toce_1908	COG1297	OPT oligopeptide transporter protein
Toce_1909	COG1228	amidohydrolase
Toce_1910	COG2362	D-Aminopeptidase
Toce_1911	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Toce_1912	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Toce_1913	COG2337	Toxic component of a toxin-antitoxin (TA) module
Toce_1915	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Toce_1916	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Toce_1916	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Toce_1917	COG0736	holo-[acyl-carrier-protein] synthase activity
Toce_1922	COG1077	Cell shape determining protein MreB Mrl
Toce_1926	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Toce_1928	COG1459	type II secretion system
Toce_1930	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Toce_1931	COG0454	-acetyltransferase
Toce_1932	COG1917	Cupin 2, conserved barrel domain protein
Toce_1932	COG1396	sequence-specific DNA binding
Toce_1933	COG0006	proline dipeptidase activity
Toce_1934	COG0531	amino acid
Toce_1940	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Toce_1945	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Toce_1947	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Toce_1950	COG1322	Protein conserved in bacteria
Toce_1957	COG2801	Transposase and inactivated derivatives
Toce_1961	COG1733	regulation of RNA biosynthetic process
Toce_1965	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Toce_1967	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Toce_1968	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Toce_1970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Toce_1972	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Toce_1973	COG0798	PFAM Bile acid sodium symporter
Toce_1974	COG0640	Transcriptional regulator
Toce_1975	COG0640	Transcriptional regulator
Toce_1978	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Toce_1982	COG1447	Phosphotransferase system cellobiose-specific component IIA
Toce_1983	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Toce_1984	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Toce_1986	COG3711	transcriptional antiterminator
Toce_1987	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Toce_1988	COG0746	molybdenum cofactor guanylyltransferase activity
Toce_1994	COG1827	regulation of RNA biosynthetic process
Toce_1997	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Toce_1998	COG4187	Peptidase family M20/M25/M40
Toce_2000	COG3829	transcription factor binding
Toce_2003	COG0745	RESPONSE REGULATOR receiver
Toce_2004	COG2205	protein histidine kinase activity
Toce_2008	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Toce_2011	COG4786	Flagellar basal body rod
Toce_2012	COG1077	Cell shape determining protein MreB Mrl
Toce_2013	COG1609	Transcriptional regulator
Toce_2015	COG2385	sporulation resulting in formation of a cellular spore
Toce_2016	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Toce_2019	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Toce_2020	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Toce_2021	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Toce_2023	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Toce_2023	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Toce_2024	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Toce_2027	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Toce_2028	COG0508	dehydrogenase complex catalyzes the overall conversion of
Toce_2029	COG3199	ATP-NAD kinase
Toce_2030	COG0022	dehydrogenase e1 component
Toce_2031	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Toce_2036	COG2801	Transposase and inactivated derivatives
Toce_2040	COG1394	ATPase activity, coupled to movement of substances
Toce_2042	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Toce_2043	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Toce_2044	COG1527	subunit (C
Toce_2046	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Toce_2047	COG1269	ATP hydrolysis coupled proton transport
Toce_2052	COG2233	PERMEase
Toce_2057	COG1966	Carbon starvation protein
Toce_2061	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Toce_2064	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Toce_2066	COG0698	ribose 5-phosphate isomerase
Toce_2068	COG0009	L-threonylcarbamoyladenylate synthase
Toce_2071	COG2890	protein-(glutamine-N5) methyltransferase activity
Toce_2072	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Toce_2073	COG3872	metal-dependent enzyme
Toce_2076	COG0454	-acetyltransferase
Toce_2078	COG3885	ferrous iron binding
Toce_2078	COG2078	PFAM AMMECR1 domain protein
Toce_2079	COG5322	oxidoreductase activity
Toce_2079	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Toce_2084	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Toce_2086	COG1592	Rubrerythrin
Toce_2086	COG1773	rubredoxin
Toce_2094	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Toce_2098	COG0037	tRNA processing
Toce_2101	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Toce_2102	COG0081	regulation of translation
Toce_2103	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Toce_2104	COG0250	Participates in transcription elongation, termination and antitermination
Toce_2106	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Toce_2107	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Toce_2110	COG3688	RNA-binding protein containing a PIN domain
Toce_2111	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Toce_2114	COG0215	cysteine-tRNA ligase activity
Toce_2115	COG1045	serine acetyltransferase
Toce_2116	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Toce_2117	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Toce_2118	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Toce_2119	COG4956	integral membrane protein (PIN domain superfamily)
Toce_2120	COG1329	Transcriptional regulator
Toce_2122	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Toce_2123	COG0542	response to heat
Toce_2124	COG3869	Catalyzes the specific phosphorylation of arginine residues in
Toce_2125	COG3880	PFAM UvrB UvrC protein
Toce_2128	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Toce_2129	COG0517	IMP dehydrogenase activity
Toce_2129	COG0516	GMP reductase activity
Toce_2130	COG1301	dicarboxylic acid transport
Toce_2133	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Toce_2134	COG0735	belongs to the Fur family
Toce_2137	COG1752	Esterase of the alpha-beta hydrolase superfamily
Toce_2138	COG1013	pyruvate-flavodoxin oxidoreductase activity
Toce_2139	COG0674	pyruvate-flavodoxin oxidoreductase activity
Toce_2140	COG1144	Oxidoreductase
Toce_2141	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Toce_2147	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Toce_2148	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Toce_2153	COG0590	tRNA wobble adenosine to inosine editing
Toce_2159	COG0456	acetyltransferase
Toce_2160	COG0726	polysaccharide deacetylase
Toce_2163	COG0577	efflux transmembrane transporter activity
Toce_2163	COG1136	(ABC) transporter
Toce_2165	COG1136	(ABC) transporter
Toce_2171	COG1136	(ABC) transporter
Toce_2177	COG0616	signal peptide processing
Toce_2179	COG1067	ATP-dependent peptidase activity
Toce_2181	COG0504	CTP synthase activity
Toce_2182	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Toce_2183	COG3829	transcription factor binding
Toce_2184	COG0018	arginyl-trna synthetase
Toce_2186	COG3273	potassium ion transport
Toce_2186	COG0471	metal ion transport
Toce_2187	COG0517	IMP dehydrogenase activity
Toce_2187	COG1125	glycine betaine transport
Toce_2189	COG1732	Glycine betaine
Toce_2190	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Toce_2191	COG2011	ABC-type metal ion transport system permease component
Toce_2194	COG0252	asparaginase activity
Toce_2195	COG1301	dicarboxylic acid transport
Toce_2196	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Toce_2199	COG1982	Orn Lys Arg decarboxylase major
Toce_2203	COG0531	amino acid
Toce_2204	COG0697	spore germination
Toce_2208	COG0174	glutamine synthetase
Toce_2209	COG0789	Transcriptional regulator
Toce_2210	COG1802	Transcriptional regulator
Toce_2213	COG0243	molybdopterin cofactor binding
Toce_2217	COG1595	DNA-templated transcription, initiation
Toce_2221	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Toce_2224	COG3875	lactate racemase activity
Toce_2235	COG5002	protein histidine kinase activity
Toce_2236	COG0745	RESPONSE REGULATOR receiver
Toce_2238	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Toce_2238	COG1116	anion transmembrane transporter activity
Toce_2241	COG2707	UPF0756 membrane protein
Toce_2242	COG0739	heme binding
Toce_2243	COG0308	aminopeptidase N
Toce_2248	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Toce_2249	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Toce_2250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Toce_2251	COG0305	Participates in initiation and elongation during chromosome replication
Toce_2252	COG0359	binds to the 23S rRNA
Toce_2253	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
Toce_2255	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Toce_2256	COG0629	single-stranded DNA binding
Toce_2257	COG0360	Binds together with S18 to 16S ribosomal RNA
Toce_2259	COG0668	transmembrane transport
Toce_2266	COG1597	lipid kinase activity
Toce_2268	COG0739	heme binding
Toce_2271	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Toce_2272	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Toce_2274	COG0840	transmembrane signaling receptor activity
Toce_2275	COG1475	DNA binding
Toce_2276	COG1192	Involved in chromosome partitioning
Toce_2280	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Toce_2281	COG1847	R3H domain protein
Toce_2282	COG0706	membrane insertase activity
Toce_2283	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Toce_2285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Toce_R0009	COG1028	Short-chain dehydrogenase reductase Sdr