locus-tag	class	description
Tmel_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Tmel_0002	COG1141	Ferredoxin
Tmel_0008	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmel_0008	COG1902	pentaerythritol trinitrate reductase activity
Tmel_0014	COG1012	belongs to the aldehyde dehydrogenase family
Tmel_0021	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Tmel_0022	COG1307	EDD domain protein, DegV family
Tmel_0023	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Tmel_0024	COG0542	response to heat
Tmel_0031	COG0492	ferredoxin-NADP+ reductase activity
Tmel_0032	COG1335	isochorismatase
Tmel_0033	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tmel_0034	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Tmel_0036	COG1564	THIamine pyrophosphokinase
Tmel_0037	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Tmel_0038	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Tmel_0039	COG4139	cobalamin transport
Tmel_0041	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tmel_0042	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Tmel_0043	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tmel_0043	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Tmel_0044	COG0307	riboflavin synthase, alpha
Tmel_0045	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmel_0045	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Tmel_0046	COG0840	transmembrane signaling receptor activity
Tmel_0047	COG0822	iron-sulfur transferase activity
Tmel_0048	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Tmel_0050	COG0719	Fe-S assembly protein
Tmel_0052	COG0459	protein refolding
Tmel_0053	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Tmel_0056	COG0312	modulator of DNA gyrase
Tmel_0057	COG0312	modulator of DNA gyrase
Tmel_0058	COG3457	Alanine racemase
Tmel_0060	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Tmel_0061	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Tmel_0063	COG0442	prolyl-tRNA aminoacylation
Tmel_0064	COG0215	cysteine-tRNA ligase activity
Tmel_0065	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tmel_0071	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmel_0072	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Tmel_0073	COG1335	isochorismatase
Tmel_0074	COG1230	cation diffusion facilitator family transporter
Tmel_0077	COG0297	glycogen (starch) synthase activity
Tmel_0079	COG3829	transcription factor binding
Tmel_0079	COG3290	protein histidine kinase activity
Tmel_0080	COG0432	Pfam Uncharacterised protein family UPF0047
Tmel_0081	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tmel_0084	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmel_0085	COG2379	hydroxypyruvate reductase
Tmel_0086	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tmel_0087	COG0484	heat shock protein binding
Tmel_0088	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tmel_0090	COG0477	Major facilitator Superfamily
Tmel_0091	COG1827	regulation of RNA biosynthetic process
Tmel_0092	COG1272	protein, Hemolysin III
Tmel_0093	COG1047	Peptidyl-prolyl cis-trans
Tmel_0095	COG0535	radical SAM domain protein
Tmel_0096	COG1363	Peptidase, m42
Tmel_0098	COG1758	RNA polymerase activity
Tmel_0099	COG0194	GDP metabolic process
Tmel_0100	COG2052	Domain of unknown function (DUF370)
Tmel_0107	COG3426	butyrate kinase activity
Tmel_0108	COG0280	phosphate acetyltransferase
Tmel_0109	COG3426	butyrate kinase activity
Tmel_0110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Tmel_0111	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tmel_0112	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Tmel_0113	COG1966	Carbon starvation protein
Tmel_0114	COG3279	Response regulator of the LytR AlgR family
Tmel_0115	COG3275	phosphorelay sensor kinase activity
Tmel_0117	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tmel_0118	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tmel_0119	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tmel_0120	COG0402	S-adenosylhomocysteine deaminase activity
Tmel_0121	COG0167	dihydroorotate dehydrogenase activity
Tmel_0122	COG2359	stage V sporulation protein S
Tmel_0123	COG0737	Belongs to the 5'-nucleotidase family
Tmel_0124	COG1132	(ABC) transporter
Tmel_0130	COG0301	tRNA thio-modification
Tmel_0133	COG1132	(ABC) transporter
Tmel_0135	COG1846	Transcriptional regulator
Tmel_0136	COG2373	Large extracellular alpha-helical protein
Tmel_0138	COG3234	Protein of unknown function (DUF1175)
Tmel_0141	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmel_0144	COG0840	transmembrane signaling receptor activity
Tmel_0147	COG0534	Mate efflux family protein
Tmel_0148	COG0667	Aldo Keto reductase
Tmel_0151	COG1131	(ABC) transporter
Tmel_0153	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tmel_0153	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tmel_0154	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Tmel_0154	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Tmel_0155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Tmel_0157	COG1573	uracil-dna glycosylase
Tmel_0158	COG0574	Belongs to the PEP-utilizing enzyme family
Tmel_0158	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Tmel_0160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tmel_0161	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Tmel_0162	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Tmel_0163	COG0193	aminoacyl-tRNA hydrolase activity
Tmel_0167	COG0529	Catalyzes the synthesis of activated sulfate
Tmel_0168	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Tmel_0169	COG4974	Belongs to the 'phage' integrase family
Tmel_0174	COG0148	phosphopyruvate hydratase activity
Tmel_0176	COG3206	protein involved in exopolysaccharide biosynthesis
Tmel_0177	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Tmel_0179	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmel_0180	COG0116	Belongs to the methyltransferase superfamily
Tmel_0181	COG1993	acr, cog1993
Tmel_0182	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Tmel_0184	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Tmel_0185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Tmel_0187	COG2264	protein methyltransferase activity
Tmel_0188	COG0739	heme binding
Tmel_0189	COG1607	acyl-coa hydrolase
Tmel_0190	COG3246	L-lysine catabolic process to acetate
Tmel_0191	COG0604	alcohol dehydrogenase
Tmel_0192	COG1509	lysine 2,3-aminomutase activity
Tmel_0193	COG2030	dehydratase
Tmel_0196	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tmel_0197	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmel_0200	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
Tmel_0206	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Tmel_0207	COG0037	tRNA processing
Tmel_0210	COG1968	undecaprenyl-diphosphatase activity
Tmel_0211	COG1228	amidohydrolase
Tmel_0214	COG0424	maF-like protein
Tmel_0215	COG2003	Belongs to the UPF0758 family
Tmel_0218	COG1215	transferase activity, transferring glycosyl groups
Tmel_0219	COG1216	Glycosyl transferase, family 2
Tmel_0219	COG1442	glycosyl transferase family 8
Tmel_0224	COG0793	Belongs to the peptidase S41A family
Tmel_0225	COG2226	methyltransferase
Tmel_0228	COG1713	HD superfamily hydrolase involved in NAD metabolism
Tmel_0230	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Tmel_0231	COG0009	L-threonylcarbamoyladenylate synthase
Tmel_0233	COG0481	GTPase activity
Tmel_0234	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Tmel_0235	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Tmel_0236	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Tmel_0237	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Tmel_0239	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Tmel_0241	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tmel_0242	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Tmel_0243	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Tmel_0244	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Tmel_0245	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmel_0246	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Tmel_0247	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Tmel_0250	COG1461	Dihydroxyacetone kinase
Tmel_0252	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Tmel_0253	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Tmel_0254	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tmel_0256	COG0495	leucyl-tRNA aminoacylation
Tmel_0260	COG0750	zinc metalloprotease
Tmel_0261	COG0745	RESPONSE REGULATOR receiver
Tmel_0261	COG3706	GGDEF domain
Tmel_0263	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Tmel_0265	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tmel_0266	COG0543	2 iron, 2 sulfur cluster binding
Tmel_0267	COG0167	dihydroorotate dehydrogenase activity
Tmel_0268	COG0284	orotidine-5'-phosphate decarboxylase activity
Tmel_0269	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Tmel_0271	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Tmel_0274	COG2183	response to ionizing radiation
Tmel_0275	COG0835	chemotaxis
Tmel_0276	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Tmel_0278	COG1278	Cold shock
Tmel_0279	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Tmel_0280	COG0095	Lipoate-protein ligase
Tmel_0284	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Tmel_0285	COG5002	protein histidine kinase activity
Tmel_0286	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Tmel_0288	COG1307	EDD domain protein, DegV family
Tmel_0289	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Tmel_0290	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Tmel_0291	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Tmel_0292	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Tmel_0293	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tmel_0294	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Tmel_0295	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Tmel_0299	COG0006	proline dipeptidase activity
Tmel_0300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Tmel_0301	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Tmel_0301	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Tmel_0302	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Tmel_0303	COG5002	protein histidine kinase activity
Tmel_0304	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Tmel_0305	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tmel_0310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tmel_0312	COG0537	adenosine 5'-monophosphoramidase activity
Tmel_0313	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Tmel_0315	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Tmel_0317	COG4112	unkown
Tmel_0318	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Tmel_0319	COG1067	ATP-dependent peptidase activity
Tmel_0320	COG0180	Tryptophanyl-tRNA synthetase
Tmel_0321	COG0668	transmembrane transport
Tmel_0322	COG0840	transmembrane signaling receptor activity
Tmel_0328	COG4786	Flagellar basal body rod
Tmel_0328	COG4786	Flagellar basal body rod
Tmel_0328	COG1256	bacterial-type flagellum assembly
Tmel_0328	COG1256	bacterial-type flagellum assembly
Tmel_0337	COG1760	l-serine dehydratase
Tmel_0339	COG1543	Belongs to the glycosyl hydrolase 57 family
Tmel_0340	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tmel_0341	COG1144	Oxidoreductase
Tmel_0342	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tmel_0343	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tmel_0344	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmel_0347	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tmel_0348	COG1518	maintenance of DNA repeat elements
Tmel_0359	COG0501	Belongs to the peptidase M48B family
Tmel_0364	COG0438	transferase activity, transferring glycosyl groups
Tmel_0367	COG0514	ATP-dependent DNA helicase (RecQ)
Tmel_0372	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tmel_0373	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Tmel_0376	COG0436	Aminotransferase
Tmel_0377	COG2045	Belongs to the ComB family
Tmel_0379	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Tmel_0381	COG0105	UTP biosynthetic process
Tmel_0383	COG3864	Putative metallopeptidase domain
Tmel_0386	COG0151	Belongs to the GarS family
Tmel_0387	COG0138	bifunctional purine biosynthesis protein purh
Tmel_0388	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Tmel_0389	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Tmel_0394	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tmel_0402	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
Tmel_0406	COG4555	ABC transporter
Tmel_0407	COG0842	Transport permease protein
Tmel_0408	COG3409	Peptidoglycan-binding domain 1 protein
Tmel_0408	COG0793	Belongs to the peptidase S41A family
Tmel_0410	COG1414	Transcriptional regulator
Tmel_0413	COG0542	response to heat
Tmel_0414	COG1773	rubredoxin
Tmel_0417	COG1187	pseudouridine synthase activity
Tmel_0418	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tmel_0419	COG1074	ATP-dependent DNA helicase activity
Tmel_0423	COG3345	alpha-galactosidase
Tmel_0424	COG1085	galactose-1-phosphate uridylyltransferase
Tmel_0425	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Tmel_0429	COG0776	regulation of translation
Tmel_0430	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Tmel_0431	COG0432	Pfam Uncharacterised protein family UPF0047
Tmel_0433	COG0803	Belongs to the bacterial solute-binding protein 9 family
Tmel_0434	COG1121	(ABC) transporter
Tmel_0435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Tmel_0437	COG0196	riboflavin kinase activity
Tmel_0438	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Tmel_0441	COG2252	PERMEase
Tmel_0451	COG0840	transmembrane signaling receptor activity
Tmel_0454	COG1131	(ABC) transporter
Tmel_0459	COG1523	belongs to the glycosyl hydrolase 13 family
Tmel_0460	COG0745	RESPONSE REGULATOR receiver
Tmel_0461	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Tmel_0463	COG0697	spore germination
Tmel_0464	COG1077	Cell shape determining protein MreB Mrl
Tmel_0470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Tmel_0471	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Tmel_0472	COG0416	fatty acid biosynthetic process
Tmel_0473	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Tmel_0476	COG1766	The M ring may be actively involved in energy transduction
Tmel_0477	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmel_0478	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Tmel_0479	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Tmel_0482	COG0528	UMP kinase activity
Tmel_0483	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Tmel_0484	COG1406	Chemotaxis phosphatase CheX
Tmel_0485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Tmel_0486	COG1181	Belongs to the D-alanine--D-alanine ligase family
Tmel_0487	COG2267	carboxylic ester hydrolase activity
Tmel_0488	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tmel_0495	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Tmel_0497	COG0784	Response regulator, receiver
Tmel_0497	COG3437	response regulator, receiver
Tmel_0498	COG3852	Histidine kinase
Tmel_0500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Tmel_0501	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Tmel_0502	COG0085	RNA polymerase activity
Tmel_0503	COG0222	ribosome binding
Tmel_0504	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Tmel_0507	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Tmel_0508	COG0367	asparagine synthase
Tmel_0509	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tmel_0511	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Tmel_0515	COG0463	Glycosyl transferase, family 2
Tmel_0515	COG0457	Tetratricopeptide repeat
Tmel_0516	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Tmel_0517	COG0305	Participates in initiation and elongation during chromosome replication
Tmel_0521	COG0251	oxidation-reduction process
Tmel_0523	COG2211	Major facilitator Superfamily
Tmel_0524	COG1803	Methylglyoxal synthase
Tmel_0525	COG0561	phosphatase activity
Tmel_0527	COG0017	Asparaginyl-tRNA synthetase
Tmel_0528	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Tmel_0531	COG1469	GTP cyclohydrolase I activity
Tmel_0533	COG0438	transferase activity, transferring glycosyl groups
Tmel_0534	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tmel_0535	COG0592	DNA-directed DNA polymerase activity
Tmel_0542	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Tmel_0546	COG1376	ErfK ybiS ycfS ynhG family protein
Tmel_0550	COG0785	Cytochrome C biogenesis protein
Tmel_0557	COG1516	flagellar protein fliS
Tmel_0560	COG4608	Belongs to the ABC transporter superfamily
Tmel_0561	COG0444	Belongs to the ABC transporter superfamily
Tmel_0563	COG0601	transmembrane transport
Tmel_0564	COG4166	transmembrane transport
Tmel_0565	COG0742	ribosomal rna small subunit methyltransferase
Tmel_0566	COG1177	transmembrane transport
Tmel_0567	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tmel_0568	COG3842	ATPase activity
Tmel_0569	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Tmel_0570	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Tmel_0571	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Tmel_0573	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tmel_0575	COG1811	Na channel or pump
Tmel_0577	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Tmel_0578	COG1480	7TM receptor with intracellular HD hydrolase
Tmel_0582	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Tmel_0583	COG0511	ligase activity, forming carbon-carbon bonds
Tmel_0586	COG0346	lactoylglutathione lyase activity
Tmel_0589	COG0653	protein targeting
Tmel_0594	COG3833	ABC-type maltose transport systems, permease component
Tmel_0595	COG1175	transmembrane transport
Tmel_0597	COG0542	response to heat
Tmel_0598	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Tmel_0601	COG0719	Fe-S assembly protein
Tmel_0603	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Tmel_0604	COG1328	CTP reductase activity
Tmel_0613	COG1525	nuclease
Tmel_0616	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
Tmel_0619	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmel_0621	COG2203	Gaf domain
Tmel_0621	COG2199	diguanylate cyclase activity
Tmel_0622	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Tmel_0626	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Tmel_0627	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Tmel_0628	COG0517	IMP dehydrogenase activity
Tmel_0628	COG0516	GMP reductase activity
Tmel_0630	COG0330	HflC and HflK could
Tmel_0631	COG1592	Rubrerythrin
Tmel_0632	COG0751	glycine-tRNA ligase activity
Tmel_0633	COG0752	glycyl-tRNA synthetase alpha subunit
Tmel_0635	COG0772	Belongs to the SEDS family
Tmel_0636	COG0360	Binds together with S18 to 16S ribosomal RNA
Tmel_0637	COG0629	single-stranded DNA binding
Tmel_0638	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Tmel_0639	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Tmel_0640	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Tmel_0641	COG0250	Participates in transcription elongation, termination and antitermination
Tmel_0642	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Tmel_0643	COG0081	regulation of translation
Tmel_0646	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Tmel_0649	COG2209	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Tmel_0651	COG4659	FMN binding
Tmel_0653	COG0662	Cupin 2, conserved barrel domain protein
Tmel_0653	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Tmel_0654	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Tmel_0655	COG2086	electron transfer activity
Tmel_0656	COG1960	acyl-CoA dehydrogenase activity
Tmel_0663	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Tmel_0665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmel_0666	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Tmel_0668	COG1706	bacterial-type flagellum-dependent cell motility
Tmel_0669	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Tmel_0671	COG0187	DNA topoisomerase II activity
Tmel_0673	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Tmel_0674	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmel_0675	COG0516	GMP reductase activity
Tmel_0675	COG0517	IMP dehydrogenase activity
Tmel_0677	COG1132	(ABC) transporter
Tmel_0682	COG2217	Heavy metal translocating P-type atpase
Tmel_0686	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Tmel_0689	COG1472	Belongs to the glycosyl hydrolase 3 family
Tmel_0691	COG1175	transmembrane transport
Tmel_0692	COG0395	ABC-type sugar transport system, permease component
Tmel_0695	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Tmel_0698	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Tmel_0706	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Tmel_0709	COG0113	porphobilinogen synthase activity
Tmel_0711	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Tmel_0712	COG0310	cobalt ion transport
Tmel_0715	COG1122	ATPase activity
Tmel_0718	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Tmel_0718	COG0519	Catalyzes the synthesis of GMP from XMP
Tmel_0720	COG1704	LemA family
Tmel_0725	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Tmel_0726	COG0306	phosphate transporter
Tmel_0729	COG0646	methionine synthase
Tmel_0729	COG1410	methionine synthase
Tmel_0731	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Tmel_0734	COG0527	aspartate kinase activity
Tmel_0734	COG0460	homoserine dehydrogenase
Tmel_0736	COG0366	Alpha amylase catalytic
Tmel_0738	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Tmel_0740	COG1131	(ABC) transporter
Tmel_0742	COG4565	transcriptional regulatory protein
Tmel_0744	COG0124	histidyl-tRNA synthetase
Tmel_0749	COG0840	transmembrane signaling receptor activity
Tmel_0750	COG3300	MHYT domain
Tmel_0750	COG5001	Diguanylate cyclase
Tmel_0751	COG0395	ABC-type sugar transport system, permease component
Tmel_0754	COG1151	hydroxylamine reductase activity
Tmel_0757	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tmel_0760	COG0384	phenazine biosynthesis protein PhzF
Tmel_0761	COG4948	Mandelate Racemase Muconate Lactonizing
Tmel_0762	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Tmel_0765	COG1486	melibiose metabolic process
Tmel_0769	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Tmel_0770	COG0366	Alpha amylase catalytic
Tmel_0773	COG3706	GGDEF domain
Tmel_0774	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmel_0777	COG1595	DNA-templated transcription, initiation
Tmel_0779	COG0210	DNA helicase
Tmel_0783	COG1546	Belongs to the CinA family
Tmel_0783	COG1058	Belongs to the CinA family
Tmel_0784	COG0504	CTP synthase activity
Tmel_0785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Tmel_0786	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Tmel_0788	COG1392	Phosphate transport regulator
Tmel_0789	COG0306	phosphate transporter
Tmel_0790	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Tmel_0797	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tmel_0798	COG4869	propanediol catabolic process
Tmel_0803	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Tmel_0804	COG1006	Multisubunit Na H antiporter MnhC subunit
Tmel_0805	COG0651	ATP synthesis coupled electron transport
Tmel_0806	COG0205	6-phosphofructokinase activity
Tmel_0807	COG1979	alcohol dehydrogenase
Tmel_0808	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tmel_0809	COG0072	phenylalanine-tRNA ligase activity
Tmel_0809	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmel_0813	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Tmel_0815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Tmel_0819	COG1175	transmembrane transport
Tmel_0820	COG0395	ABC-type sugar transport system, permease component
Tmel_0821	COG0840	transmembrane signaling receptor activity
Tmel_0822	COG3706	GGDEF domain
Tmel_0823	COG4399	Belongs to the UPF0754 family
Tmel_0824	COG0445	tRNA wobble uridine modification
Tmel_0825	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Tmel_0826	COG1489	DNA binding
Tmel_0829	COG0640	Transcriptional regulator
Tmel_0830	COG0534	Mate efflux family protein
Tmel_0831	COG0488	(ABC) transporter
Tmel_0834	COG0489	protein tyrosine kinase activity
Tmel_0836	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Tmel_0837	COG0242	peptide deformylase activity
Tmel_0838	COG0513	Belongs to the DEAD box helicase family
Tmel_0840	COG1137	ATPase activity
Tmel_0843	COG0745	RESPONSE REGULATOR receiver
Tmel_0845	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Tmel_0847	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tmel_0849	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmel_0850	COG1684	flagellar biosynthetic protein fliR
Tmel_0852	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tmel_0853	COG2199	diguanylate cyclase activity
Tmel_0853	COG2203	Gaf domain
Tmel_0855	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Tmel_0857	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Tmel_0860	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Tmel_0867	COG1187	pseudouridine synthase activity
Tmel_0868	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Tmel_0870	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Tmel_0871	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Tmel_0876	COG1116	anion transmembrane transporter activity
Tmel_0882	COG0628	permease
Tmel_0889	COG1196	nuclear chromosome segregation
Tmel_0890	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Tmel_0891	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Tmel_0904	COG1506	peptidase
Tmel_0904	COG0823	Involved in the tonB-independent uptake of proteins
Tmel_0904	COG4946	Tricorn protease homolog
Tmel_0909	COG5012	cobalamin binding
Tmel_0910	COG0084	hydrolase, TatD family'
Tmel_0911	COG0632	four-way junction helicase activity
Tmel_0915	COG5002	protein histidine kinase activity
Tmel_0917	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tmel_0922	COG0469	pyruvate kinase activity
Tmel_0923	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Tmel_0924	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Tmel_0925	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Tmel_0926	COG0052	Belongs to the universal ribosomal protein uS2 family
Tmel_0927	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Tmel_0928	COG1987	bacterial-type flagellum assembly
Tmel_0929	COG1338	Plays a role in the flagellum-specific transport system
Tmel_0931	COG2201	protein-glutamate methylesterase activity
Tmel_0932	COG0835	chemotaxis
Tmel_0933	COG2198	Histidine kinase
Tmel_0933	COG0643	Histidine kinase
Tmel_0935	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Tmel_0937	COG0101	tRNA pseudouridine synthase activity
Tmel_0941	COG0714	Associated with various cellular activities
Tmel_0943	COG0772	Belongs to the SEDS family
Tmel_0944	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Tmel_0946	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Tmel_0947	COG0154	amidase activity
Tmel_0948	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Tmel_0949	COG0049	tRNA binding
Tmel_0950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tmel_0951	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Tmel_0952	COG0051	transcription antitermination factor activity, RNA binding
Tmel_0953	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Tmel_0954	COG0088	Forms part of the polypeptide exit tunnel
Tmel_0955	COG0089	rRNA binding
Tmel_0956	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tmel_0957	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Tmel_0958	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Tmel_0959	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Tmel_0960	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Tmel_0961	COG0255	Belongs to the universal ribosomal protein uL29 family
Tmel_0962	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Tmel_0963	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Tmel_0964	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Tmel_0965	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tmel_0966	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Tmel_0967	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Tmel_0968	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Tmel_0969	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Tmel_0970	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Tmel_0971	COG1841	ribosomal large subunit assembly
Tmel_0972	COG0200	Binds to the 23S rRNA
Tmel_0973	COG0201	protein transport
Tmel_0974	COG0563	adenylate kinase activity
Tmel_0976	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Tmel_0977	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Tmel_0978	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tmel_0979	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Tmel_0980	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Tmel_0981	COG0202	RNA polymerase activity
Tmel_0982	COG0203	ribosomal protein L17
Tmel_0983	COG0544	peptidyl-prolyl cis-trans isomerase activity
Tmel_0984	COG0740	serine-type endopeptidase activity
Tmel_0985	COG0217	transcriptional regulatory protein
Tmel_0987	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Tmel_0988	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Tmel_0989	COG0564	pseudouridine synthase activity
Tmel_0990	COG0174	glutamine synthetase
Tmel_0991	COG2342	PFAM TM1410 hypothetical-related protein
Tmel_1000	COG1214	PFAM Peptidase M22, glycoprotease
Tmel_1001	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Tmel_1002	COG2770	Histidine kinase
Tmel_1002	COG3437	response regulator, receiver
Tmel_1003	COG2078	PFAM AMMECR1 domain protein
Tmel_1006	COG0037	tRNA processing
Tmel_1007	COG3681	Belongs to the UPF0597 family
Tmel_1009	COG1070	Carbohydrate kinase
Tmel_1010	COG1509	lysine 2,3-aminomutase activity
Tmel_1012	COG1609	Transcriptional regulator
Tmel_1013	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
Tmel_1014	COG0395	ABC-type sugar transport system, permease component
Tmel_1015	COG1175	transmembrane transport
Tmel_1017	COG1653	transport
Tmel_1021	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Tmel_1024	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Tmel_1025	COG3481	metal-dependent phosphohydrolase, HD sub domain
Tmel_1026	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Tmel_1027	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Tmel_1029	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Tmel_1030	COG0358	DNA primase activity
Tmel_1031	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Tmel_1032	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Tmel_1033	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Tmel_1034	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Tmel_1036	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Tmel_1038	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Tmel_1039	COG2176	DNA-directed DNA polymerase activity
Tmel_1040	COG2359	stage V sporulation protein S
Tmel_1042	COG3872	metal-dependent enzyme
Tmel_1043	COG0019	diaminopimelate decarboxylase activity
Tmel_1044	COG1473	amidohydrolase
Tmel_1045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Tmel_1046	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Tmel_1047	COG0012	GTP binding
Tmel_1048	COG2052	Domain of unknown function (DUF370)
Tmel_1049	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmel_1050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tmel_1053	COG0546	phosphoglycolate phosphatase activity
Tmel_1055	COG2070	2-Nitropropane dioxygenase
Tmel_1063	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Tmel_1064	COG0438	transferase activity, transferring glycosyl groups
Tmel_1075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Tmel_1081	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Tmel_1088	COG2865	translation initiation factor activity
Tmel_1120	COG0840	transmembrane signaling receptor activity
Tmel_1121	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Tmel_1122	COG0850	regulation of cytokinetic process
Tmel_1124	COG1815	bacterial-type flagellum-dependent cell motility
Tmel_1126	COG1677	Flagellar hook-basal body complex protein FliE
Tmel_1128	COG0443	Heat shock 70 kDa protein
Tmel_1129	COG0393	Putative heavy-metal-binding
Tmel_1130	COG1073	alpha beta
Tmel_1133	COG1725	Transcriptional regulator
Tmel_1136	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Tmel_1137	COG1785	Belongs to the alkaline phosphatase family
Tmel_1139	COG0543	2 iron, 2 sulfur cluster binding
Tmel_1140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Tmel_1141	COG1940	carbohydrate kinase activity
Tmel_1146	COG2201	protein-glutamate methylesterase activity
Tmel_1147	COG2201	protein-glutamate methylesterase activity
Tmel_1148	COG0643	Histidine kinase
Tmel_1148	COG2198	Histidine kinase
Tmel_1152	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Tmel_1155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Tmel_1156	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Tmel_1157	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Tmel_1158	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Tmel_1159	COG2137	regulation of response to DNA damage stimulus
Tmel_1160	COG1418	mRNA catabolic process
Tmel_1161	COG3842	ATPase activity
Tmel_1164	COG1309	transcriptional regulator
Tmel_1165	COG0254	rRNA binding
Tmel_1166	COG1098	S1 RNA binding domain
Tmel_1174	COG0483	inositol monophosphate 1-phosphatase activity
Tmel_1175	COG0768	penicillin binding
Tmel_1176	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Tmel_1178	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Tmel_1180	COG1610	YqeY-like protein
Tmel_1182	COG0698	ribose 5-phosphate isomerase
Tmel_1184	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tmel_1186	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Tmel_1187	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmel_1187	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Tmel_1188	COG0747	negative chemotaxis
Tmel_1191	COG0444	Belongs to the ABC transporter superfamily
Tmel_1192	COG4608	Belongs to the ABC transporter superfamily
Tmel_1193	COG0540	Belongs to the ATCase OTCase family
Tmel_1193	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Tmel_1194	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tmel_1194	COG2199	diguanylate cyclase activity
Tmel_1195	COG0735	belongs to the Fur family
Tmel_1196	COG0450	alkyl hydroperoxide reductase
Tmel_1197	COG1773	rubredoxin
Tmel_1198	COG0426	domain, Protein
Tmel_1199	COG1528	Iron-storage protein
Tmel_1201	COG2033	superoxide reductase activity
Tmel_1204	COG2770	Histidine kinase
Tmel_1204	COG3437	response regulator, receiver
Tmel_1206	COG1435	thymidine kinase activity
Tmel_1207	COG0737	Belongs to the 5'-nucleotidase family
Tmel_1209	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Tmel_1210	COG1863	multisubunit Na H antiporter MnhE subunit
Tmel_1211	COG2212	antiporter activity
Tmel_1214	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Tmel_1214	COG2111	Na H antiporter
Tmel_1215	COG1006	Multisubunit Na H antiporter MnhC subunit
Tmel_1216	COG0651	ATP synthesis coupled electron transport
Tmel_1219	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmel_1220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Tmel_1221	COG0649	NAD binding
Tmel_1227	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Tmel_1229	COG0446	pyridine nucleotide-disulphide oxidoreductase
Tmel_1230	COG1045	serine acetyltransferase
Tmel_1231	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tmel_1232	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Tmel_1233	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Tmel_1234	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tmel_1235	COG0047	phosphoribosylformylglycinamidine synthase activity
Tmel_1236	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Tmel_1239	COG2313	pseudouridylate synthase activity
Tmel_1240	COG0622	Phosphoesterase
Tmel_1241	COG1739	Uncharacterized protein family UPF0029
Tmel_1242	COG0436	Aminotransferase
Tmel_1243	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Tmel_1244	COG0640	Transcriptional regulator
Tmel_1258	COG0720	synthase
Tmel_1259	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Tmel_1264	COG0149	triose-phosphate isomerase activity
Tmel_1264	COG0126	phosphoglycerate kinase activity
Tmel_1265	COG0126	phosphoglycerate kinase activity
Tmel_1266	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Tmel_1269	COG1157	protein secretion by the type III secretion system
Tmel_1271	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Tmel_1272	COG0191	fructose-bisphosphate aldolase activity
Tmel_1275	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Tmel_1276	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Tmel_1278	COG0233	cytoplasmic translational termination
Tmel_1279	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Tmel_1280	COG0575	Belongs to the CDS family
Tmel_1281	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Tmel_1282	COG1077	Cell shape determining protein MreB Mrl
Tmel_1285	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Tmel_1289	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Tmel_1292	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Tmel_1293	COG1749	Flagellar hook protein flgE
Tmel_1294	COG1582	Flagellar protein (FlbD)
Tmel_1296	COG1360	Flagellar Motor Protein
Tmel_1298	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmel_1299	COG1776	CheC inhibitor of MCP methylation
Tmel_1299	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Tmel_1300	COG0733	neurotransmitter:sodium symporter activity
Tmel_1302	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Tmel_1303	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Tmel_1304	COG2239	Acts as a magnesium transporter
Tmel_1306	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Tmel_1307	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Tmel_1310	COG1120	ATPase activity
Tmel_1314	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Tmel_1315	COG1490	D-aminoacyl-tRNA deacylase activity
Tmel_1316	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Tmel_1319	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Tmel_1319	COG2080	2 iron, 2 sulfur cluster binding
Tmel_1324	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Tmel_1327	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Tmel_1329	COG1030	water channel activity
Tmel_1333	COG0019	diaminopimelate decarboxylase activity
Tmel_1335	COG0357	Ribosomal RNA small subunit methyltransferase G
Tmel_1336	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Tmel_1344	COG2203	Gaf domain
Tmel_1344	COG2199	diguanylate cyclase activity
Tmel_1345	COG0584	glycerophosphoryl diester phosphodiesterase
Tmel_1346	COG0156	8-amino-7-oxononanoate synthase activity
Tmel_1347	COG1063	alcohol dehydrogenase
Tmel_1353	COG0534	Mate efflux family protein
Tmel_1360	COG1027	Aspartate ammonia-lyase
Tmel_1361	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Tmel_1363	COG0142	geranyltranstransferase activity
Tmel_1366	COG1078	dGTPase activity
Tmel_1367	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Tmel_1372	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Tmel_1373	COG1660	Displays ATPase and GTPase activities
Tmel_1374	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Tmel_1376	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Tmel_1377	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Tmel_1378	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Tmel_1380	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Tmel_1382	COG1132	(ABC) transporter
Tmel_1384	COG0444	Belongs to the ABC transporter superfamily
Tmel_1385	COG4608	Belongs to the ABC transporter superfamily
Tmel_1387	COG0601	transmembrane transport
Tmel_1388	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Tmel_1393	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Tmel_1394	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Tmel_1395	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Tmel_1397	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Tmel_1398	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Tmel_1401	COG1752	Esterase of the alpha-beta hydrolase superfamily
Tmel_1402	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Tmel_1404	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tmel_1404	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tmel_1408	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Tmel_1409	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Tmel_1411	COG0735	belongs to the Fur family
Tmel_1412	COG0195	Participates in both transcription termination and antitermination
Tmel_1413	COG0779	Required for maturation of 30S ribosomal subunits
Tmel_1416	COG0343	queuine tRNA-ribosyltransferase activity
Tmel_1418	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Tmel_1419	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Tmel_1420	COG2151	metal-sulfur cluster biosynthetic enzyme
Tmel_1421	COG2890	protein-(glutamine-N5) methyltransferase activity
Tmel_1422	COG0359	binds to the 23S rRNA
Tmel_1423	COG1234	tRNA 3'-trailer cleavage
Tmel_1425	COG0617	tRNA 3'-terminal CCA addition
Tmel_1432	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Tmel_1433	COG1776	CheC inhibitor of MCP methylation
Tmel_1436	COG0455	bacterial-type flagellum organization
Tmel_1437	COG1419	protein localization to endoplasmic reticulum
Tmel_1438	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Tmel_1472	COG3723	Recombinational DNA repair protein, rece pathway
Tmel_1473	COG5377	YqaJ viral recombinase family
Tmel_1479	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Tmel_1487	COG0730	response to heat
Tmel_1490	COG1774	PSP1 C-terminal conserved region
Tmel_1492	COG0802	atpase or kinase
Tmel_1493	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Tmel_1494	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Tmel_1496	COG5002	protein histidine kinase activity
Tmel_1497	COG1639	'signal transduction protein
Tmel_1498	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Tmel_1500	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Tmel_1503	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Tmel_1505	COG1162	GTPase activity
Tmel_1506	COG1032	radical SAM domain protein
Tmel_1508	COG0295	cytidine deaminase activity
Tmel_1511	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Tmel_1513	COG0557	exoribonuclease II activity
Tmel_1514	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Tmel_1514	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Tmel_1515	COG2738	Putative neutral zinc metallopeptidase
Tmel_1516	COG0745	RESPONSE REGULATOR receiver
Tmel_1517	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Tmel_1518	COG3956	TIGRFAM MazG family protein
Tmel_1519	COG0628	permease
Tmel_1524	COG0587	DNA-directed DNA polymerase activity
Tmel_1525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Tmel_1526	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Tmel_1527	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Tmel_1528	COG2199	diguanylate cyclase activity
Tmel_1528	COG2203	Gaf domain
Tmel_1529	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Tmel_1530	COG1362	aminopeptidase activity
Tmel_1535	COG1482	cell wall glycoprotein biosynthetic process
Tmel_1537	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Tmel_1538	COG2255	four-way junction helicase activity
Tmel_1539	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Tmel_1541	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Tmel_1542	COG0704	Plays a role in the regulation of phosphate uptake
Tmel_1544	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Tmel_1545	COG0138	bifunctional purine biosynthesis protein purh
Tmel_1549	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Tmel_1550	COG2894	cell division
Tmel_1555	COG0552	protein localization to endoplasmic reticulum
Tmel_1557	COG3584	3D domain protein
Tmel_1559	COG0482	sulfurtransferase activity
Tmel_1560	COG0037	tRNA processing
Tmel_1560	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Tmel_1561	COG1316	TRANSCRIPTIONal
Tmel_1562	COG1515	deoxyribonuclease V activity
Tmel_1565	COG1242	4 iron, 4 sulfur cluster binding
Tmel_1566	COG0402	S-adenosylhomocysteine deaminase activity
Tmel_1567	COG0799	negative regulation of ribosome biogenesis
Tmel_1568	COG0285	dihydrofolate synthase activity
Tmel_1569	COG0525	valine-tRNA ligase activity
Tmel_1571	COG4656	Part of a membrane complex involved in electron transport
Tmel_1572	COG4658	electron transport chain
Tmel_1574	COG4660	Part of a membrane complex involved in electron transport
Tmel_1575	COG4657	Part of a membrane complex involved in electron transport
Tmel_1576	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Tmel_1578	COG0516	GMP reductase activity
Tmel_1578	COG0517	IMP dehydrogenase activity
Tmel_1579	COG0840	transmembrane signaling receptor activity
Tmel_1580	COG0366	Alpha amylase catalytic
Tmel_1581	COG1073	alpha beta
Tmel_1581	COG2226	methyltransferase
Tmel_1582	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Tmel_1583	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Tmel_1584	COG0157	Belongs to the NadC ModD family
Tmel_1585	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Tmel_1586	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Tmel_1588	COG1268	BioY protein
Tmel_1589	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Tmel_1590	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Tmel_1592	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Tmel_1594	COG0351	phosphomethylpyrimidine kinase
Tmel_1594	COG1992	Thiamine-phosphate synthase
Tmel_1595	COG0205	6-phosphofructokinase activity
Tmel_1597	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Tmel_1604	COG0571	ribonuclease III activity
Tmel_1605	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Tmel_1605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Tmel_1606	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Tmel_1606	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Tmel_1607	COG0728	peptidoglycan biosynthetic process
Tmel_1609	COG0758	DNA mediated transformation
Tmel_1610	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Tmel_1612	COG1185	polyribonucleotide nucleotidyltransferase activity
Tmel_1613	COG0612	Peptidase, M16
Tmel_1615	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Tmel_1616	COG1175	transmembrane transport
Tmel_1618	COG0395	ABC-type sugar transport system, permease component
Tmel_1619	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Tmel_1620	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Tmel_1621	COG1366	Belongs to the anti-sigma-factor antagonist family
Tmel_1622	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Tmel_1623	COG0539	negative regulation of cytoplasmic translation
Tmel_1623	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Tmel_1624	COG1160	GTP binding
Tmel_1628	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Tmel_1629	COG0594	ribonuclease P activity
Tmel_1630	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Tmel_1631	COG0706	membrane insertase activity
Tmel_1632	COG1847	R3H domain protein
Tmel_1634	COG0569	domain protein
Tmel_1634	COG2985	domain, Protein
Tmel_1635	COG0174	glutamine synthetase
Tmel_1636	COG2199	diguanylate cyclase activity
Tmel_1636	COG2203	Gaf domain
Tmel_1638	COG2723	6-phospho-beta-galactosidase activity
Tmel_1648	COG1132	(ABC) transporter
Tmel_1650	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tmel_1651	COG1518	maintenance of DNA repeat elements
Tmel_1652	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Tmel_1661	COG3337	CRISPR-associated protein (Cas_Cmr5)
Tmel_1670	COG1353	crispr-associated protein
Tmel_1672	COG1337	RAMP superfamily
Tmel_1682	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Tmel_1686	COG0556	nucleotide-excision repair
Tmel_1688	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Tmel_1691	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Tmel_1695	COG2361	Protein of unknown function DUF86
Tmel_1699	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Tmel_1701	COG0438	transferase activity, transferring glycosyl groups
Tmel_1702	COG3842	ATPase activity
Tmel_1716	COG3842	ATPase activity
Tmel_1717	COG0438	transferase activity, transferring glycosyl groups
Tmel_1722	COG0730	response to heat
Tmel_1723	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tmel_1726	COG0768	penicillin binding
Tmel_1727	COG0275	rRNA processing
Tmel_1729	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Tmel_1731	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Tmel_1732	COG4608	Belongs to the ABC transporter superfamily
Tmel_1735	COG0601	transmembrane transport
Tmel_1736	COG0322	excinuclease ABC activity
Tmel_1738	COG0509	glycine decarboxylation via glycine cleavage system
Tmel_1739	COG1918	ferrous iron import across plasma membrane
Tmel_1739	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Tmel_1741	COG1555	photosystem II stabilization
Tmel_1741	COG1596	polysaccharide export
Tmel_1743	COG4796	Type ii and iii secretion system protein
Tmel_1750	COG1122	ATPase activity
Tmel_1751	COG2813	Specifically methylates the guanine in position
Tmel_1755	COG0268	Binds directly to 16S ribosomal RNA
Tmel_1756	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Tmel_1759	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Tmel_1760	COG1923	regulation of RNA biosynthetic process
Tmel_1763	COG0572	uridine kinase
Tmel_1764	COG1530	ribonuclease E activity
Tmel_1765	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Tmel_1767	COG1013	pyruvate-flavodoxin oxidoreductase activity
Tmel_1770	COG2201	protein-glutamate methylesterase activity
Tmel_1771	COG0497	DNA recombination
Tmel_1776	COG0840	transmembrane signaling receptor activity
Tmel_1777	COG2986	histidine ammonia-lyase
Tmel_1785	COG1363	Peptidase, m42
Tmel_1790	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Tmel_1791	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Tmel_1793	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Tmel_1793	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Tmel_1795	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Tmel_1797	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Tmel_1798	COG0058	SHG alpha-glucan phosphorylase activity
Tmel_1799	COG0681	Belongs to the peptidase S26 family
Tmel_1800	COG0335	large ribosomal subunit rRNA binding
Tmel_1801	COG4752	Belongs to the RNA methyltransferase TrmD family
Tmel_1802	COG0336	Belongs to the RNA methyltransferase TrmD family
Tmel_1803	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Tmel_1804	COG1837	Belongs to the UPF0109 family
Tmel_1805	COG0228	four-way junction DNA binding
Tmel_1806	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Tmel_1808	COG1176	ABC-type spermidine putrescine transport system, permease component I
Tmel_1811	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
Tmel_1814	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Tmel_1816	COG0840	transmembrane signaling receptor activity
Tmel_1817	COG2199	diguanylate cyclase activity
Tmel_1817	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Tmel_1820	COG1653	transport
Tmel_1821	COG0438	transferase activity, transferring glycosyl groups
Tmel_1823	COG5002	protein histidine kinase activity
Tmel_1824	COG0745	RESPONSE REGULATOR receiver
Tmel_1825	COG0704	Plays a role in the regulation of phosphate uptake
Tmel_1826	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Tmel_1827	COG0573	inorganic phosphate transmembrane transporter activity
Tmel_1830	COG1012	belongs to the aldehyde dehydrogenase family
Tmel_1831	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Tmel_1832	COG1846	Transcriptional regulator
Tmel_1834	COG1105	Belongs to the carbohydrate kinase PfkB family
Tmel_1835	COG1028	Short-chain dehydrogenase reductase Sdr
Tmel_1836	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Tmel_1837	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tmel_1838	COG0745	RESPONSE REGULATOR receiver
Tmel_1842	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Tmel_1843	COG0166	Belongs to the GPI family
Tmel_1845	COG0237	dephospho-CoA kinase activity
Tmel_1846	COG2199	diguanylate cyclase activity
Tmel_1847	COG0556	nucleotide-excision repair
Tmel_1854	COG1323	Belongs to the UPF0348 family
Tmel_1855	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Tmel_1857	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Tmel_1858	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Tmel_1859	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Tmel_1861	COG0235	Class ii aldolase
Tmel_1863	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tmel_1863	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Tmel_1865	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Tmel_1867	COG3290	protein histidine kinase activity
Tmel_1867	COG0840	transmembrane signaling receptor activity
Tmel_1870	COG0045	succinate-CoA ligase (ADP-forming) activity
Tmel_1872	COG0569	domain protein
Tmel_1872	COG2985	domain, Protein
Tmel_1873	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Tmel_1874	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Tmel_1875	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Tmel_1876	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Tmel_1877	COG2171	N-acyltransferase activity
Tmel_1879	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Tmel_1881	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Tmel_1882	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Tmel_1885	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Tmel_1886	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmel_1887	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tmel_1888	COG1454	alcohol dehydrogenase
Tmel_1892	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Tmel_1893	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Tmel_1896	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Tmel_1896	COG0674	pyruvate-flavodoxin oxidoreductase activity
Tmel_1897	COG1144	Oxidoreductase
Tmel_1898	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Tmel_1899	COG0470	DNA polymerase III
Tmel_1900	COG1122	ATPase activity
Tmel_1901	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
Tmel_1904	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmel_1905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Tmel_1906	COG1862	Preprotein translocase
Tmel_1907	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Tmel_1909	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Tmel_1910	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Tmel_1913	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Tmel_1916	COG1570	exodeoxyribonuclease VII activity
Tmel_1917	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tmel_1917	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Tmel_1920	COG1193	negative regulation of DNA recombination
Tmel_1922	COG0306	phosphate transporter
Tmel_1925	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Tmel_1928	COG0280	phosphate acetyltransferase