locus-tag	class	description
Y592_00020	COG0514	ATP-dependent DNA helicase (RecQ)
Y592_00025	COG0758	DNA mediated transformation
Y592_00030	COG1752	Esterase of the alpha-beta hydrolase superfamily
Y592_00060	COG0768	penicillin binding
Y592_00070	COG0275	rRNA processing
Y592_00090	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Y592_00095	COG4608	Belongs to the ABC transporter superfamily
Y592_00110	COG0601	transmembrane transport
Y592_00115	COG0322	excinuclease ABC activity
Y592_00125	COG0509	glycine decarboxylation via glycine cleavage system
Y592_00130	COG1918	ferrous iron import across plasma membrane
Y592_00130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Y592_00135	COG1918	ferrous iron import across plasma membrane
Y592_00150	COG1596	polysaccharide export
Y592_00150	COG1555	photosystem II stabilization
Y592_00155	COG1355	regulation of microtubule-based process
Y592_00160	COG4796	Type ii and iii secretion system protein
Y592_00195	COG1122	ATPase activity
Y592_00200	COG2813	Specifically methylates the guanine in position
Y592_00205	COG1773	rubredoxin
Y592_00205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Y592_00210	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Y592_00220	COG0268	Binds directly to 16S ribosomal RNA
Y592_00225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Y592_00240	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Y592_00245	COG1923	regulation of RNA biosynthetic process
Y592_00260	COG0572	uridine kinase
Y592_00265	COG1530	ribonuclease E activity
Y592_00270	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Y592_00275	COG2131	deaminase
Y592_00280	COG1013	pyruvate-flavodoxin oxidoreductase activity
Y592_00295	COG2201	protein-glutamate methylesterase activity
Y592_00300	COG0497	DNA recombination
Y592_00310	COG0840	transmembrane signaling receptor activity
Y592_00315	COG2986	histidine ammonia-lyase
Y592_00355	COG1363	Peptidase, m42
Y592_00380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Y592_00385	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Y592_00395	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Y592_00395	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Y592_00415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Y592_00420	COG0058	SHG alpha-glucan phosphorylase activity
Y592_00425	COG0681	Belongs to the peptidase S26 family
Y592_00430	COG0335	large ribosomal subunit rRNA binding
Y592_00435	COG4752	Belongs to the RNA methyltransferase TrmD family
Y592_00440	COG0336	Belongs to the RNA methyltransferase TrmD family
Y592_00445	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Y592_00450	COG1837	Belongs to the UPF0109 family
Y592_00455	COG0228	four-way junction DNA binding
Y592_00460	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Y592_00485	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
Y592_00500	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Y592_00510	COG0840	transmembrane signaling receptor activity
Y592_00515	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Y592_00515	COG0731	radical SAM domain protein
Y592_00530	COG3279	Response regulator of the LytR AlgR family
Y592_00535	COG1966	Carbon starvation protein
Y592_00540	COG1215	transferase activity, transferring glycosyl groups
Y592_00555	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Y592_00585	COG1337	RAMP superfamily
Y592_00595	COG1353	crispr-associated protein
Y592_00625	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Y592_00630	COG1518	maintenance of DNA repeat elements
Y592_00635	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Y592_00650	COG0154	amidase activity
Y592_00665	COG1653	transport
Y592_00670	COG0438	transferase activity, transferring glycosyl groups
Y592_00680	COG5002	protein histidine kinase activity
Y592_00685	COG0745	RESPONSE REGULATOR receiver
Y592_00690	COG0704	Plays a role in the regulation of phosphate uptake
Y592_00695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Y592_00715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y592_00730	COG1105	Belongs to the carbohydrate kinase PfkB family
Y592_00735	COG1028	Short-chain dehydrogenase reductase Sdr
Y592_00740	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
Y592_00745	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Y592_00750	COG0745	RESPONSE REGULATOR receiver
Y592_00755	COG5002	protein histidine kinase activity
Y592_00770	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Y592_00775	COG0166	Belongs to the GPI family
Y592_00785	COG0237	dephospho-CoA kinase activity
Y592_00790	COG3706	GGDEF domain
Y592_00795	COG0556	nucleotide-excision repair
Y592_00825	COG1323	Belongs to the UPF0348 family
Y592_00830	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Y592_00835	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
Y592_00840	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Y592_00845	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Y592_00855	COG0235	Class ii aldolase
Y592_00865	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Y592_00865	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Y592_00875	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Y592_00885	COG0840	transmembrane signaling receptor activity
Y592_00900	COG1785	Belongs to the alkaline phosphatase family
Y592_00910	COG0045	succinate-CoA ligase (ADP-forming) activity
Y592_00920	COG2985	domain, Protein
Y592_00920	COG0569	domain protein
Y592_00930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Y592_00940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Y592_00945	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Y592_00950	COG2171	N-acyltransferase activity
Y592_00955	COG0527	aspartate kinase activity
Y592_00960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Y592_00970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Y592_00980	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Y592_00985	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y592_00990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Y592_00995	COG1454	alcohol dehydrogenase
Y592_01000	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Y592_01015	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y592_01020	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Y592_01025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Y592_01025	COG0674	pyruvate-flavodoxin oxidoreductase activity
Y592_01035	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
Y592_01045	COG1122	ATPase activity
Y592_01050	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
Y592_01065	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y592_01070	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Y592_01075	COG1862	Preprotein translocase
Y592_01080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Y592_01090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Y592_01095	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Y592_01110	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Y592_01130	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y592_01130	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Y592_01145	COG1193	negative regulation of DNA recombination
Y592_01170	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Y592_01180	COG0549	Belongs to the carbamate kinase family
Y592_01185	COG0280	phosphate acetyltransferase
Y592_01195	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Y592_01200	COG1141	Ferredoxin
Y592_01240	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Y592_01245	COG1307	EDD domain protein, DegV family
Y592_01250	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Y592_01255	COG0542	response to heat
Y592_01285	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Y592_01295	COG1335	isochorismatase
Y592_01300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Y592_01305	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Y592_01310	COG1136	(ABC) transporter
Y592_01320	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Y592_01325	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Y592_01330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Y592_01340	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y592_01355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Y592_01360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Y592_01365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y592_01365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Y592_01370	COG0307	riboflavin synthase, alpha
Y592_01375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y592_01375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Y592_01380	COG0840	transmembrane signaling receptor activity
Y592_01385	COG0822	iron-sulfur transferase activity
Y592_01390	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Y592_01395	COG0719	Fe-S assembly protein
Y592_01400	COG0719	Fe-S assembly protein
Y592_01420	COG0459	protein refolding
Y592_01425	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Y592_01440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
Y592_01450	COG0312	modulator of DNA gyrase
Y592_01455	COG0312	modulator of DNA gyrase
Y592_01460	COG3457	Alanine racemase
Y592_01470	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Y592_01475	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Y592_01485	COG2378	regulation of single-species biofilm formation
Y592_01510	COG1468	defense response to virus
Y592_01510	COG1518	maintenance of DNA repeat elements
Y592_01520	COG0442	prolyl-tRNA aminoacylation
Y592_01525	COG0215	cysteine-tRNA ligase activity
Y592_01530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y592_01535	COG2233	PERMEase
Y592_01545	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y592_01550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
Y592_01555	COG1335	isochorismatase
Y592_01560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Y592_01575	COG0297	glycogen (starch) synthase activity
Y592_01585	COG3829	transcription factor binding
Y592_01585	COG3290	protein histidine kinase activity
Y592_01595	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y592_01600	COG2379	hydroxypyruvate reductase
Y592_01605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Y592_01610	COG0484	heat shock protein binding
Y592_01615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Y592_01620	COG1420	regulation of RNA biosynthetic process
Y592_01625	COG0477	Major facilitator Superfamily
Y592_01630	COG1827	regulation of RNA biosynthetic process
Y592_01635	COG1272	protein, Hemolysin III
Y592_01640	COG1047	Peptidyl-prolyl cis-trans
Y592_01655	COG1363	Peptidase, m42
Y592_01665	COG1758	RNA polymerase activity
Y592_01670	COG0194	GDP metabolic process
Y592_01675	COG2052	Domain of unknown function (DUF370)
Y592_01710	COG3426	butyrate kinase activity
Y592_01715	COG0280	phosphate acetyltransferase
Y592_01720	COG3426	butyrate kinase activity
Y592_01725	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Y592_01730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Y592_01735	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Y592_01755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y592_01760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Y592_01805	COG2359	stage V sporulation protein S
Y592_01815	COG0737	Belongs to the 5'-nucleotidase family
Y592_01820	COG1132	(ABC) transporter
Y592_01850	COG0301	tRNA thio-modification
Y592_01855	COG1937	Protein conserved in bacteria
Y592_01860	COG1132	(ABC) transporter
Y592_01880	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y592_01895	COG0534	Mate efflux family protein
Y592_01900	COG0667	Aldo Keto reductase
Y592_01915	COG1131	(ABC) transporter
Y592_01925	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Y592_01925	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Y592_01930	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Y592_01930	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Y592_01945	COG1573	uracil-dna glycosylase
Y592_01950	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Y592_01950	COG0574	Belongs to the PEP-utilizing enzyme family
Y592_01960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Y592_01965	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Y592_01970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Y592_01975	COG0193	aminoacyl-tRNA hydrolase activity
Y592_01995	COG0529	Catalyzes the synthesis of activated sulfate
Y592_02000	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Y592_02005	COG4974	Belongs to the 'phage' integrase family
Y592_02010	COG0148	phosphopyruvate hydratase activity
Y592_02025	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Y592_02040	COG0116	Belongs to the methyltransferase superfamily
Y592_02045	COG1993	acr, cog1993
Y592_02050	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Y592_02060	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Y592_02065	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Y592_02075	COG2264	protein methyltransferase activity
Y592_02080	COG0739	heme binding
Y592_02085	COG1607	acyl-coa hydrolase
Y592_02090	COG3246	L-lysine catabolic process to acetate
Y592_02095	COG0604	alcohol dehydrogenase
Y592_02100	COG1509	lysine 2,3-aminomutase activity
Y592_02105	COG2030	dehydratase
Y592_02115	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Y592_02120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Y592_02125	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y592_02160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Y592_02165	COG0037	tRNA processing
Y592_02180	COG1968	undecaprenyl-diphosphatase activity
Y592_02185	COG1228	amidohydrolase
Y592_02200	COG0424	maF-like protein
Y592_02205	COG2003	Belongs to the UPF0758 family
Y592_02220	COG1215	transferase activity, transferring glycosyl groups
Y592_02225	COG0463	Glycosyl transferase, family 2
Y592_02250	COG0793	Belongs to the peptidase S41A family
Y592_02270	COG1713	HD superfamily hydrolase involved in NAD metabolism
Y592_02275	COG1550	Protein conserved in bacteria
Y592_02280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Y592_02285	COG0009	L-threonylcarbamoyladenylate synthase
Y592_02295	COG0481	GTPase activity
Y592_02300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Y592_02305	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Y592_02310	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Y592_02315	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Y592_02325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Y592_02335	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Y592_02340	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Y592_02345	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Y592_02350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Y592_02355	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Y592_02360	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
Y592_02365	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
Y592_02380	COG1461	Dihydroxyacetone kinase
Y592_02390	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Y592_02395	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Y592_02400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Y592_02410	COG0495	leucyl-tRNA aminoacylation
Y592_02415	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Y592_02425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Y592_02430	COG0750	zinc metalloprotease
Y592_02435	COG2203	Gaf domain
Y592_02435	COG2199	diguanylate cyclase activity
Y592_02440	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y592_02445	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Y592_02455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Y592_02460	COG0543	2 iron, 2 sulfur cluster binding
Y592_02465	COG0167	dihydroorotate dehydrogenase activity
Y592_02470	COG0284	orotidine-5'-phosphate decarboxylase activity
Y592_02475	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Y592_02500	COG2183	response to ionizing radiation
Y592_02505	COG0835	chemotaxis
Y592_02510	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Y592_02520	COG1278	Cold shock
Y592_02525	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Y592_02530	COG0095	Lipoate-protein ligase
Y592_02550	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Y592_02555	COG3852	Histidine kinase
Y592_02560	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Y592_02570	COG1307	EDD domain protein, DegV family
Y592_02575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Y592_02580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Y592_02585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Y592_02590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Y592_02595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Y592_02600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Y592_02605	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Y592_02625	COG0006	proline dipeptidase activity
Y592_02635	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Y592_02640	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
Y592_02640	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Y592_02650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Y592_02655	COG5002	protein histidine kinase activity
Y592_02660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Y592_02665	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Y592_02670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Y592_02680	COG0537	adenosine 5'-monophosphoramidase activity
Y592_02685	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Y592_02695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Y592_02705	COG4112	unkown
Y592_02710	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Y592_02715	COG1067	ATP-dependent peptidase activity
Y592_02720	COG0180	Tryptophanyl-tRNA synthetase
Y592_02725	COG0668	transmembrane transport
Y592_02730	COG0840	transmembrane signaling receptor activity
Y592_02745	COG4786	Flagellar basal body rod
Y592_02745	COG4786	Flagellar basal body rod
Y592_02745	COG1256	bacterial-type flagellum assembly
Y592_02745	COG1256	bacterial-type flagellum assembly
Y592_02750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Y592_02795	COG1760	l-serine dehydratase
Y592_02805	COG1543	Belongs to the glycosyl hydrolase 57 family
Y592_02810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Y592_02815	COG1144	Oxidoreductase
Y592_02820	COG0674	pyruvate-flavodoxin oxidoreductase activity
Y592_02825	COG1013	pyruvate-flavodoxin oxidoreductase activity
Y592_02835	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y592_02870	COG2199	diguanylate cyclase activity
Y592_02870	COG2203	Gaf domain
Y592_02875	COG0542	response to heat
Y592_02880	COG1773	rubredoxin
Y592_02900	COG4399	Belongs to the UPF0754 family
Y592_02905	COG1187	pseudouridine synthase activity
Y592_02915	COG1074	ATP-dependent DNA helicase activity
Y592_02930	COG0776	regulation of translation
Y592_02935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Y592_02940	COG0432	Pfam Uncharacterised protein family UPF0047
Y592_02950	COG0803	Belongs to the bacterial solute-binding protein 9 family
Y592_02955	COG1121	(ABC) transporter
Y592_02960	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Y592_02970	COG0196	riboflavin kinase activity
Y592_02975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Y592_02990	COG2252	PERMEase
Y592_03045	COG1131	(ABC) transporter
Y592_03050	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
Y592_03070	COG1523	belongs to the glycosyl hydrolase 13 family
Y592_03075	COG0745	RESPONSE REGULATOR receiver
Y592_03080	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Y592_03090	COG0697	spore germination
Y592_03095	COG1077	Cell shape determining protein MreB Mrl
Y592_03100	COG4786	Flagellar basal body rod
Y592_03125	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Y592_03130	COG0416	fatty acid biosynthetic process
Y592_03135	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Y592_03155	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y592_03160	COG2176	DNA-directed DNA polymerase activity
Y592_03165	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Y592_03175	COG4717	serine-type aminopeptidase activity
Y592_03180	COG0528	UMP kinase activity
Y592_03185	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
Y592_03190	COG1406	Chemotaxis phosphatase CheX
Y592_03195	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Y592_03200	COG1181	Belongs to the D-alanine--D-alanine ligase family
Y592_03230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Y592_03245	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Y592_03270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Y592_03275	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Y592_03290	COG0436	Aminotransferase
Y592_03295	COG2045	Belongs to the ComB family
Y592_03305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Y592_03315	COG0105	UTP biosynthetic process
Y592_03325	COG3864	Putative metallopeptidase domain
Y592_03335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Y592_03340	COG0151	Belongs to the GarS family
Y592_03345	COG0138	bifunctional purine biosynthesis protein purh
Y592_03350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Y592_03355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Y592_03370	COG1132	(ABC) transporter
Y592_03380	COG0515	serine threonine protein kinase
Y592_03415	COG1132	(ABC) transporter
Y592_03445	COG0840	transmembrane signaling receptor activity
Y592_03460	COG3833	ABC-type maltose transport systems, permease component
Y592_03465	COG1175	transmembrane transport
Y592_03475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Y592_03490	COG0719	Fe-S assembly protein
Y592_03495	COG1137	ATPase activity
Y592_03540	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y592_03550	COG1879	ABC-type sugar transport system periplasmic component
Y592_03555	COG1172	Belongs to the binding-protein-dependent transport system permease family
Y592_03560	COG1129	ABC transporter
Y592_03565	COG1869	D-ribose catabolic process
Y592_03590	COG4948	Mandelate Racemase Muconate Lactonizing
Y592_03620	COG1328	CTP reductase activity
Y592_03670	COG1525	nuclease
Y592_03705	COG0579	oxidoreductase
Y592_03710	COG3706	GGDEF domain
Y592_03710	COG0745	RESPONSE REGULATOR receiver
Y592_03715	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Y592_03740	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Y592_03745	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Y592_03750	COG0516	GMP reductase activity
Y592_03750	COG0517	IMP dehydrogenase activity
Y592_03755	COG0330	HflC and HflK could
Y592_03760	COG0330	HflC and HflK could
Y592_03765	COG1592	Rubrerythrin
Y592_03770	COG0751	glycine-tRNA ligase activity
Y592_03775	COG0752	glycyl-tRNA synthetase alpha subunit
Y592_03785	COG0772	Belongs to the SEDS family
Y592_03800	COG0360	Binds together with S18 to 16S ribosomal RNA
Y592_03805	COG0629	single-stranded DNA binding
Y592_03810	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Y592_03825	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Y592_03835	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Y592_03840	COG0250	Participates in transcription elongation, termination and antitermination
Y592_03845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Y592_03850	COG0081	regulation of translation
Y592_03875	COG3706	GGDEF domain
Y592_03885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Y592_03905	COG1347	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
Y592_03910	COG4659	FMN binding
Y592_03925	COG0489	protein tyrosine kinase activity
Y592_03925	COG3206	protein involved in exopolysaccharide biosynthesis
Y592_03930	COG1596	polysaccharide export
Y592_03940	COG0613	PHP domain protein
Y592_03945	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Y592_03955	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y592_03960	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Y592_03975	COG1706	bacterial-type flagellum-dependent cell motility
Y592_03980	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Y592_03985	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
Y592_03990	COG0187	DNA topoisomerase II activity
Y592_04000	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Y592_04005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y592_04010	COG0517	IMP dehydrogenase activity
Y592_04010	COG0516	GMP reductase activity
Y592_04205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Y592_04210	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Y592_04220	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Y592_04235	COG0438	transferase activity, transferring glycosyl groups
Y592_04245	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Y592_04255	COG1086	Polysaccharide biosynthesis protein
Y592_04265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Y592_04345	COG0501	Belongs to the peptidase M48B family
Y592_04375	COG0445	tRNA wobble uridine modification
Y592_04380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Y592_04385	COG1489	DNA binding
Y592_04400	COG0640	Transcriptional regulator
Y592_04405	COG0534	Mate efflux family protein
Y592_04410	COG0488	(ABC) transporter
Y592_04420	COG0489	protein tyrosine kinase activity
Y592_04430	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Y592_04435	COG0242	peptide deformylase activity
Y592_04440	COG0513	Belongs to the DEAD box helicase family
Y592_04450	COG1137	ATPase activity
Y592_04465	COG0745	RESPONSE REGULATOR receiver
Y592_04475	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Y592_04485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y592_04495	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y592_04500	COG1684	flagellar biosynthetic protein fliR
Y592_04505	COG0840	transmembrane signaling receptor activity
Y592_04510	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Y592_04515	COG4869	propanediol catabolic process
Y592_04520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Y592_04540	COG0306	phosphate transporter
Y592_04545	COG0306	phosphate transporter
Y592_04550	COG1392	Phosphate transport regulator
Y592_04570	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Y592_04575	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Y592_04580	COG0504	CTP synthase activity
Y592_04585	COG1546	Belongs to the CinA family
Y592_04585	COG1058	Belongs to the CinA family
Y592_04605	COG0210	DNA helicase
Y592_04615	COG1595	DNA-templated transcription, initiation
Y592_04630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y592_04650	COG0366	Alpha amylase catalytic
Y592_04655	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Y592_04675	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
Y592_04690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Y592_04695	COG0384	phenazine biosynthesis protein PhzF
Y592_04700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Y592_04710	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y592_04725	COG1151	hydroxylamine reductase activity
Y592_04740	COG0395	ABC-type sugar transport system, permease component
Y592_04745	COG3345	alpha-galactosidase
Y592_04750	COG3300	MHYT domain
Y592_04750	COG5001	Diguanylate cyclase
Y592_04755	COG0840	transmembrane signaling receptor activity
Y592_04780	COG0124	histidyl-tRNA synthetase
Y592_04790	COG4565	transcriptional regulatory protein
Y592_04800	COG1131	(ABC) transporter
Y592_04810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Y592_04815	COG0366	Alpha amylase catalytic
Y592_04825	COG0840	transmembrane signaling receptor activity
Y592_04830	COG1410	methionine synthase
Y592_04830	COG0646	methionine synthase
Y592_04835	COG1476	TRANSCRIPTIONal
Y592_04850	COG0840	transmembrane signaling receptor activity
Y592_04855	COG0791	NLP P60 protein
Y592_04855	COG3883	PFAM NLP P60 protein
Y592_04865	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y592_04875	COG1704	LemA family
Y592_04880	COG0519	Catalyzes the synthesis of GMP from XMP
Y592_04880	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y592_04890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Y592_04895	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Y592_04905	COG0395	ABC-type sugar transport system, permease component
Y592_04910	COG1175	transmembrane transport
Y592_04920	COG1472	Belongs to the glycosyl hydrolase 3 family
Y592_04935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Y592_04945	COG2217	Heavy metal translocating P-type atpase
Y592_04990	COG0297	glycogen (starch) synthase activity
Y592_04990	COG0438	transferase activity, transferring glycosyl groups
Y592_05015	COG0745	RESPONSE REGULATOR receiver
Y592_05015	COG3706	GGDEF domain
Y592_05020	COG0395	ABC-type sugar transport system, permease component
Y592_05025	COG1175	transmembrane transport
Y592_05040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Y592_05060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Y592_05080	COG0072	phenylalanine-tRNA ligase activity
Y592_05080	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y592_05085	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Y592_05090	COG1979	alcohol dehydrogenase
Y592_05095	COG0205	6-phosphofructokinase activity
Y592_05105	COG1006	Multisubunit Na H antiporter MnhC subunit
Y592_05110	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Y592_05115	COG2199	diguanylate cyclase activity
Y592_05115	COG2203	Gaf domain
Y592_05140	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Y592_05145	COG1492	cobalamin metabolic process
Y592_05175	COG1187	pseudouridine synthase activity
Y592_05180	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Y592_05200	COG1116	anion transmembrane transporter activity
Y592_05240	COG0628	permease
Y592_05275	COG1196	nuclear chromosome segregation
Y592_05285	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Y592_05335	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Y592_05365	COG5012	cobalamin binding
Y592_05370	COG0084	hydrolase, TatD family'
Y592_05375	COG0632	four-way junction helicase activity
Y592_05405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y592_05415	COG0154	amidase activity
Y592_05420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Y592_05430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Y592_05435	COG0772	Belongs to the SEDS family
Y592_05445	COG3706	GGDEF domain
Y592_05450	COG0101	tRNA pseudouridine synthase activity
Y592_05460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Y592_05470	COG2198	Histidine kinase
Y592_05470	COG0643	Histidine kinase
Y592_05475	COG0835	chemotaxis
Y592_05480	COG2201	protein-glutamate methylesterase activity
Y592_05490	COG1338	Plays a role in the flagellum-specific transport system
Y592_05495	COG1987	bacterial-type flagellum assembly
Y592_05500	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Y592_05505	COG0052	Belongs to the universal ribosomal protein uS2 family
Y592_05510	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Y592_05515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Y592_05520	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Y592_05540	COG0469	pyruvate kinase activity
Y592_05555	COG0564	pseudouridine synthase activity
Y592_05570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Y592_05575	COG0049	tRNA binding
Y592_05580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Y592_05585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Y592_05590	COG0051	transcription antitermination factor activity, RNA binding
Y592_05595	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Y592_05600	COG0088	Forms part of the polypeptide exit tunnel
Y592_05605	COG0089	rRNA binding
Y592_05610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Y592_05615	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Y592_05620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Y592_05625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Y592_05630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Y592_05635	COG0255	Belongs to the universal ribosomal protein uL29 family
Y592_05640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Y592_05645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Y592_05650	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Y592_05655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Y592_05660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Y592_05665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Y592_05670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Y592_05675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Y592_05680	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Y592_05685	COG1841	ribosomal large subunit assembly
Y592_05690	COG0200	Binds to the 23S rRNA
Y592_05695	COG0201	protein transport
Y592_05700	COG0563	adenylate kinase activity
Y592_05710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Y592_05715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Y592_05720	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Y592_05725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Y592_05730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Y592_05735	COG0202	RNA polymerase activity
Y592_05740	COG0203	ribosomal protein L17
Y592_05745	COG0544	peptidyl-prolyl cis-trans isomerase activity
Y592_05750	COG0740	serine-type endopeptidase activity
Y592_05755	COG0217	transcriptional regulatory protein
Y592_05765	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Y592_05775	COG0564	pseudouridine synthase activity
Y592_05780	COG0174	glutamine synthetase
Y592_05785	COG2342	PFAM TM1410 hypothetical-related protein
Y592_05825	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y592_05825	COG2199	diguanylate cyclase activity
Y592_05835	COG1214	PFAM Peptidase M22, glycoprotease
Y592_05840	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Y592_05850	COG2078	PFAM AMMECR1 domain protein
Y592_05865	COG0037	tRNA processing
Y592_05870	COG3681	Belongs to the UPF0597 family
Y592_05880	COG1070	Carbohydrate kinase
Y592_05885	COG1509	lysine 2,3-aminomutase activity
Y592_05905	COG5394	Polyhydroxyalkanoate synthesis repressor PhaR
Y592_05920	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Y592_05925	COG3481	metal-dependent phosphohydrolase, HD sub domain
Y592_05930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Y592_05940	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Y592_05950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Y592_05955	COG0358	DNA primase activity
Y592_05960	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Y592_05965	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Y592_05970	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
Y592_05975	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Y592_05980	COG2868	ribosomal protein
Y592_05985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Y592_06000	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Y592_06005	COG2176	DNA-directed DNA polymerase activity
Y592_06010	COG2359	stage V sporulation protein S
Y592_06020	COG3872	metal-dependent enzyme
Y592_06025	COG0019	diaminopimelate decarboxylase activity
Y592_06030	COG1473	amidohydrolase
Y592_06035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Y592_06040	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Y592_06045	COG0012	GTP binding
Y592_06050	COG2052	Domain of unknown function (DUF370)
Y592_06055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y592_06060	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y592_06080	COG3437	response regulator, receiver
Y592_06080	COG0784	Response regulator, receiver
Y592_06095	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Y592_06100	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Y592_06105	COG0085	RNA polymerase activity
Y592_06110	COG0222	ribosome binding
Y592_06115	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Y592_06130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Y592_06135	COG0305	Participates in initiation and elongation during chromosome replication
Y592_06145	COG0251	oxidation-reduction process
Y592_06155	COG2211	Major facilitator Superfamily
Y592_06160	COG1803	Methylglyoxal synthase
Y592_06165	COG0561	phosphatase activity
Y592_06175	COG0017	Asparaginyl-tRNA synthetase
Y592_06180	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Y592_06195	COG1469	GTP cyclohydrolase I activity
Y592_06205	COG0438	transferase activity, transferring glycosyl groups
Y592_06210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Y592_06215	COG0592	DNA-directed DNA polymerase activity
Y592_06220	COG4969	Belongs to the N-Me-Phe pilin family
Y592_06225	COG4555	ABC transporter
Y592_06270	COG1376	ErfK ybiS ycfS ynhG family protein
Y592_06275	COG1028	Short-chain dehydrogenase reductase Sdr
Y592_06290	COG0785	Cytochrome C biogenesis protein
Y592_06335	COG1516	flagellar protein fliS
Y592_06350	COG4608	Belongs to the ABC transporter superfamily
Y592_06355	COG0444	Belongs to the ABC transporter superfamily
Y592_06365	COG0601	transmembrane transport
Y592_06375	COG0742	ribosomal rna small subunit methyltransferase
Y592_06380	COG1177	transmembrane transport
Y592_06385	COG1176	ABC-type spermidine putrescine transport system, permease component I
Y592_06390	COG3842	ATPase activity
Y592_06395	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Y592_06400	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Y592_06405	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Y592_06415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y592_06425	COG1811	Na channel or pump
Y592_06430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Y592_06435	COG1480	7TM receptor with intracellular HD hydrolase
Y592_06440	COG1702	phosphate starvation-inducible protein PhoH
Y592_06450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Y592_06455	COG5016	pyruvate
Y592_06455	COG0511	ligase activity, forming carbon-carbon bonds
Y592_06470	COG0346	lactoylglutathione lyase activity
Y592_06485	COG0653	protein targeting
Y592_06490	COG0850	regulation of cytokinetic process
Y592_06515	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Y592_06535	COG1677	Flagellar hook-basal body complex protein FliE
Y592_06540	COG0071	Belongs to the small heat shock protein (HSP20) family
Y592_06545	COG0443	Heat shock 70 kDa protein
Y592_06550	COG0393	Putative heavy-metal-binding
Y592_06555	COG1073	alpha beta
Y592_06570	COG1725	Transcriptional regulator
Y592_06585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
Y592_06590	COG0493	'glutamate synthase
Y592_06590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Y592_06595	COG0543	2 iron, 2 sulfur cluster binding
Y592_06605	COG1940	carbohydrate kinase activity
Y592_06625	COG2201	protein-glutamate methylesterase activity
Y592_06665	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Y592_06670	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Y592_06675	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Y592_06680	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Y592_06685	COG2137	regulation of response to DNA damage stimulus
Y592_06690	COG1418	mRNA catabolic process
Y592_06695	COG3842	ATPase activity
Y592_06710	COG1309	transcriptional regulator
Y592_06715	COG0254	rRNA binding
Y592_06720	COG1098	S1 RNA binding domain
Y592_06755	COG0483	inositol monophosphate 1-phosphatase activity
Y592_06760	COG0768	penicillin binding
Y592_06765	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Y592_06785	COG1610	YqeY-like protein
Y592_06795	COG0698	ribose 5-phosphate isomerase
Y592_06800	COG1366	Belongs to the anti-sigma-factor antagonist family
Y592_06805	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Y592_06810	COG1371	PFAM Archease protein family (DUF101 UPF0211)
Y592_06815	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Y592_06820	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y592_06820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Y592_06840	COG0444	Belongs to the ABC transporter superfamily
Y592_06845	COG4608	Belongs to the ABC transporter superfamily
Y592_06850	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Y592_06850	COG0540	Belongs to the ATCase OTCase family
Y592_06855	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Y592_06855	COG2199	diguanylate cyclase activity
Y592_06860	COG0735	belongs to the Fur family
Y592_06865	COG0450	alkyl hydroperoxide reductase
Y592_06870	COG1773	rubredoxin
Y592_06880	COG1528	Iron-storage protein
Y592_06890	COG2033	superoxide reductase activity
Y592_06910	COG1435	thymidine kinase activity
Y592_06915	COG0737	Belongs to the 5'-nucleotidase family
Y592_06925	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
Y592_06930	COG1863	multisubunit Na H antiporter MnhE subunit
Y592_06935	COG2212	antiporter activity
Y592_06950	COG2111	Na H antiporter
Y592_06950	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Y592_06955	COG1006	Multisubunit Na H antiporter MnhC subunit
Y592_06960	COG0651	ATP synthesis coupled electron transport
Y592_06965	COG0651	ATP synthesis coupled electron transport
Y592_06975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Y592_06980	COG0649	NAD binding
Y592_06985	COG0649	NAD binding
Y592_06990	COG0493	'glutamate synthase
Y592_07030	COG0489	protein tyrosine kinase activity
Y592_07035	COG0446	pyridine nucleotide-disulphide oxidoreductase
Y592_07045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Y592_07055	COG1045	serine acetyltransferase
Y592_07065	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Y592_07070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Y592_07075	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Y592_07080	COG0047	phosphoribosylformylglycinamidine synthase activity
Y592_07085	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Y592_07100	COG2313	pseudouridylate synthase activity
Y592_07105	COG0622	Phosphoesterase
Y592_07110	COG1739	Uncharacterized protein family UPF0029
Y592_07115	COG0436	Aminotransferase
Y592_07120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Y592_07125	COG0640	Transcriptional regulator
Y592_07140	COG0720	synthase
Y592_07145	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Y592_07150	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Y592_07170	COG0149	triose-phosphate isomerase activity
Y592_07170	COG0126	phosphoglycerate kinase activity
Y592_07175	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Y592_07190	COG1157	protein secretion by the type III secretion system
Y592_07200	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Y592_07205	COG0191	fructose-bisphosphate aldolase activity
Y592_07225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Y592_07230	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Y592_07240	COG0233	cytoplasmic translational termination
Y592_07245	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Y592_07250	COG0575	Belongs to the CDS family
Y592_07255	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Y592_07260	COG1077	Cell shape determining protein MreB Mrl
Y592_07275	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Y592_07295	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Y592_07310	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Y592_07320	COG1582	Flagellar protein (FlbD)
Y592_07330	COG1360	Flagellar Motor Protein
Y592_07340	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y592_07345	COG1776	CheC inhibitor of MCP methylation
Y592_07345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Y592_07355	COG0733	neurotransmitter:sodium symporter activity
Y592_07365	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Y592_07370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Y592_07375	COG2239	Acts as a magnesium transporter
Y592_07385	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Y592_07390	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Y592_07405	COG1120	ATPase activity
Y592_07410	COG0741	lytic transglycosylase activity
Y592_07425	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Y592_07430	COG1490	D-aminoacyl-tRNA deacylase activity
Y592_07435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Y592_07450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Y592_07450	COG2080	2 iron, 2 sulfur cluster binding
Y592_07455	COG2080	2 iron, 2 sulfur cluster binding
Y592_07475	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Y592_07490	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Y592_07505	COG0330	HflC and HflK could
Y592_07515	COG3314	Sporulation integral membrane protein YlbJ
Y592_07520	COG0019	diaminopimelate decarboxylase activity
Y592_07540	COG0357	Ribosomal RNA small subunit methyltransferase G
Y592_07545	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Y592_07585	COG0584	glycerophosphoryl diester phosphodiesterase
Y592_07590	COG0156	8-amino-7-oxononanoate synthase activity
Y592_07595	COG1063	alcohol dehydrogenase
Y592_07600	COG0534	Mate efflux family protein
Y592_07630	COG1027	Aspartate ammonia-lyase
Y592_07635	COG1160	GTP binding
Y592_07655	COG0572	uridine kinase
Y592_07660	COG1078	dGTPase activity
Y592_07665	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Y592_07675	COG1994	Peptidase M50
Y592_07690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Y592_07695	COG1660	Displays ATPase and GTPase activities
Y592_07700	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Y592_07710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Y592_07715	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Y592_07720	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Y592_07730	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Y592_07740	COG1132	(ABC) transporter
Y592_07750	COG0444	Belongs to the ABC transporter superfamily
Y592_07755	COG4608	Belongs to the ABC transporter superfamily
Y592_07765	COG0601	transmembrane transport
Y592_07770	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Y592_07805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Y592_07810	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Y592_07815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Y592_07825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Y592_07830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Y592_07850	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Y592_07855	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Y592_07855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Y592_07875	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Y592_07880	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Y592_07890	COG0735	belongs to the Fur family
Y592_07895	COG0195	Participates in both transcription termination and antitermination
Y592_07900	COG0779	Required for maturation of 30S ribosomal subunits
Y592_07925	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y592_07930	COG1419	protein localization to endoplasmic reticulum
Y592_07935	COG0455	bacterial-type flagellum organization
Y592_07950	COG1776	CheC inhibitor of MCP methylation
Y592_07955	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
Y592_07960	COG1191	sigma factor activity
Y592_07990	COG0617	tRNA 3'-terminal CCA addition
Y592_08000	COG1234	tRNA 3'-trailer cleavage
Y592_08005	COG0359	binds to the 23S rRNA
Y592_08010	COG2890	protein-(glutamine-N5) methyltransferase activity
Y592_08015	COG2151	metal-sulfur cluster biosynthetic enzyme
Y592_08020	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Y592_08025	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Y592_08035	COG0343	queuine tRNA-ribosyltransferase activity
Y592_08050	COG0730	response to heat
Y592_08055	COG1774	PSP1 C-terminal conserved region
Y592_08065	COG0802	atpase or kinase
Y592_08070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Y592_08075	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Y592_08085	COG5002	protein histidine kinase activity
Y592_08090	COG1639	'signal transduction protein
Y592_08095	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Y592_08105	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Y592_08125	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Y592_08135	COG1162	GTPase activity
Y592_08140	COG1032	radical SAM domain protein
Y592_08165	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Y592_08175	COG0557	exoribonuclease II activity
Y592_08180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Y592_08180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Y592_08185	COG2738	Putative neutral zinc metallopeptidase
Y592_08195	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Y592_08200	COG3956	TIGRFAM MazG family protein
Y592_08205	COG0628	permease
Y592_08230	COG0587	DNA-directed DNA polymerase activity
Y592_08235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Y592_08240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Y592_08245	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Y592_08250	COG2203	Gaf domain
Y592_08250	COG4251	negative regulation of phosphorylation
Y592_08250	COG5001	Diguanylate cyclase
Y592_08250	COG3706	GGDEF domain
Y592_08255	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Y592_08260	COG1362	aminopeptidase activity
Y592_08285	COG1482	cell wall glycoprotein biosynthetic process
Y592_08295	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Y592_08300	COG2255	four-way junction helicase activity
Y592_08305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Y592_08315	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Y592_08320	COG0704	Plays a role in the regulation of phosphate uptake
Y592_08330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Y592_08335	COG0138	bifunctional purine biosynthesis protein purh
Y592_08345	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Y592_08355	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Y592_08360	COG2894	cell division
Y592_08385	COG0552	protein localization to endoplasmic reticulum
Y592_08400	COG1959	2 iron, 2 sulfur cluster binding
Y592_08405	COG0482	sulfurtransferase activity
Y592_08415	COG1316	TRANSCRIPTIONal
Y592_08420	COG1515	deoxyribonuclease V activity
Y592_08430	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Y592_08445	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Y592_08450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Y592_08455	COG0157	Belongs to the NadC ModD family
Y592_08460	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Y592_08475	COG0366	Alpha amylase catalytic
Y592_08480	COG0840	transmembrane signaling receptor activity
Y592_08485	COG0517	IMP dehydrogenase activity
Y592_08485	COG0516	GMP reductase activity
Y592_08495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Y592_08505	COG4657	Part of a membrane complex involved in electron transport
Y592_08510	COG4660	Part of a membrane complex involved in electron transport
Y592_08520	COG4658	electron transport chain
Y592_08525	COG4656	Part of a membrane complex involved in electron transport
Y592_08535	COG0525	valine-tRNA ligase activity
Y592_08540	COG0285	dihydrofolate synthase activity
Y592_08545	COG0799	negative regulation of ribosome biogenesis
Y592_08550	COG0402	S-adenosylhomocysteine deaminase activity
Y592_08555	COG1242	4 iron, 4 sulfur cluster binding
Y592_08560	COG4555	ABC transporter
Y592_08565	COG0842	Transport permease protein
Y592_08575	COG0641	radical SAM
Y592_08615	COG1132	(ABC) transporter
Y592_08645	COG1132	(ABC) transporter
Y592_08765	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Y592_08780	COG0351	phosphomethylpyrimidine kinase
Y592_08780	COG1992	Thiamine-phosphate synthase
Y592_08785	COG0205	6-phosphofructokinase activity
Y592_08795	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Y592_08830	COG0571	ribonuclease III activity
Y592_08835	COG0519	Catalyzes the synthesis of GMP from XMP
Y592_08835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Y592_08840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Y592_08840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Y592_08845	COG0728	peptidoglycan biosynthetic process
Y592_08855	COG0758	DNA mediated transformation
Y592_08860	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Y592_08870	COG1185	polyribonucleotide nucleotidyltransferase activity
Y592_08875	COG0612	Peptidase, M16
Y592_08885	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Y592_08890	COG1175	transmembrane transport
Y592_08895	COG0395	ABC-type sugar transport system, permease component
Y592_08900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Y592_08905	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Y592_08910	COG1366	Belongs to the anti-sigma-factor antagonist family
Y592_08915	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Y592_08920	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Y592_08925	COG1160	GTP binding
Y592_08945	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Y592_08950	COG0594	ribonuclease P activity
Y592_08955	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Y592_08960	COG0706	membrane insertase activity
Y592_08965	COG1847	R3H domain protein
Y592_08980	COG0174	glutamine synthetase
Y592_08985	COG2203	Gaf domain
Y592_08985	COG2199	diguanylate cyclase activity
Y592_08995	COG2723	6-phospho-beta-galactosidase activity
Y592_09025	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Y592_09060	COG1454	alcohol dehydrogenase
Y592_09060	COG1012	belongs to the aldehyde dehydrogenase family
Y592_09085	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Y592_09120	COG1337	RAMP superfamily
Y592_09180	COG2264	protein methyltransferase activity
Y592_09190	COG2373	Large extracellular alpha-helical protein
Y592_09200	COG3234	Protein of unknown function (DUF1175)
Y592_09215	COG0730	response to heat
Y592_09220	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Y592_09245	COG3842	ATPase activity
Y592_09250	COG0438	transferase activity, transferring glycosyl groups