locus-tag	class	description
TST_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TST_0002	COG0592	DNA-directed DNA polymerase activity
TST_0003	COG0187	DNA topoisomerase II activity
TST_0004	COG0154	amidase activity
TST_0005	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TST_0006	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TST_0008	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TST_0009	COG0004	ammonium transporteR
TST_0010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TST_0010	COG0069	glutamate synthase activity
TST_0013	COG0067	glutamate synthase
TST_0015	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TST_0016	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TST_0018	COG0674	pyruvate-flavodoxin oxidoreductase activity
TST_0019	COG1013	pyruvate-flavodoxin oxidoreductase activity
TST_0021	COG0589	response to stress
TST_0022	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TST_0025	COG0750	zinc metalloprotease
TST_0026	COG1278	Cold shock
TST_0030	COG0633	Ferredoxin
TST_0031	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TST_0032	COG1478	Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives
TST_0032	COG0778	Nitroreductase
TST_0036	COG0116	Belongs to the methyltransferase superfamily
TST_0037	COG2252	PERMEase
TST_0040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TST_0041	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TST_0042	COG2204	response regulator
TST_0043	COG5000	phosphorelay sensor kinase activity
TST_0044	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TST_0051	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TST_0056	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TST_0057	COG2226	methyltransferase
TST_0060	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
TST_0064	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TST_0065	COG3264	Mechanosensitive ion channel
TST_0065	COG1196	nuclear chromosome segregation
TST_0066	COG0653	protein targeting
TST_0067	COG1994	Peptidase M50
TST_0068	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TST_0069	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TST_0070	COG4974	Belongs to the 'phage' integrase family
TST_0071	COG0194	GDP metabolic process
TST_0072	COG1561	YicC-like family, N-terminal region
TST_0073	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TST_0075	COG0243	molybdopterin cofactor binding
TST_0078	COG0348	domain, Protein
TST_0079	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TST_0081	COG0315	cyclic pyranopterin monophosphate synthase activity
TST_0081	COG0521	Mo-molybdopterin cofactor biosynthetic process
TST_0082	COG0746	molybdenum cofactor guanylyltransferase activity
TST_0084	COG4149	molybdate abc transporter
TST_0085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TST_0089	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TST_0090	COG4974	Belongs to the 'phage' integrase family
TST_0092	COG0585	pseudouridine synthase activity
TST_0093	COG0306	phosphate transporter
TST_0094	COG1392	Phosphate transport regulator
TST_0095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TST_0096	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TST_0097	COG0217	transcriptional regulatory protein
TST_0100	COG0779	Required for maturation of 30S ribosomal subunits
TST_0101	COG0195	Participates in both transcription termination and antitermination
TST_0103	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TST_0103	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TST_0104	COG1550	Protein conserved in bacteria
TST_0105	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TST_0106	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TST_0107	COG1024	Enoyl-CoA hydratase
TST_0108	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TST_0109	COG1271	oxidase subunit
TST_0110	COG1294	oxidase, subunit
TST_0113	COG1396	sequence-specific DNA binding
TST_0114	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TST_0116	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TST_0117	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TST_0119	COG0357	Ribosomal RNA small subunit methyltransferase G
TST_0120	COG1851	Uncharacterised protein family (UPF0128)
TST_0121	COG1332	CRISPR-associated RAMP protein, Csm5 family
TST_0122	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TST_0124	COG3706	GGDEF domain
TST_0126	COG4822	anaerobic cobalamin biosynthetic process
TST_0127	COG1131	(ABC) transporter
TST_0128	COG0842	Transport permease protein
TST_0129	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TST_0130	COG1120	ATPase activity
TST_0131	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TST_0132	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TST_0132	COG1648	precorrin-2 dehydrogenase activity
TST_0136	COG0358	DNA primase activity
TST_0137	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TST_0144	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TST_0145	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TST_0147	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TST_0148	COG0006	proline dipeptidase activity
TST_0150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TST_0151	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TST_0154	COG2003	Belongs to the UPF0758 family
TST_0155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TST_0156	COG0706	membrane insertase activity
TST_0157	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TST_0158	COG0594	ribonuclease P activity
TST_0164	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TST_0165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TST_0167	COG1012	belongs to the aldehyde dehydrogenase family
TST_0169	COG1309	transcriptional regulator
TST_0170	COG1024	Enoyl-CoA hydratase
TST_0170	COG1250	3-hydroxyacyl-CoA dehydrogenase
TST_0171	COG0183	Belongs to the thiolase family
TST_0172	COG1960	acyl-CoA dehydrogenase activity
TST_0174	COG0318	PFAM AMP-dependent synthetase and ligase
TST_0179	COG1012	belongs to the aldehyde dehydrogenase family
TST_0181	COG0318	PFAM AMP-dependent synthetase and ligase
TST_0182	COG0318	PFAM AMP-dependent synthetase and ligase
TST_0188	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TST_0189	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TST_0190	COG1333	cytochrome c biogenesis protein
TST_0192	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
TST_0193	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TST_0195	COG4956	integral membrane protein (PIN domain superfamily)
TST_0196	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TST_0196	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TST_0197	COG5001	Diguanylate cyclase
TST_0197	COG2203	Gaf domain
TST_0197	COG3706	GGDEF domain
TST_0197	COG4251	negative regulation of phosphorylation
TST_0199	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TST_0200	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TST_0202	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TST_0204	COG1034	ATP synthesis coupled electron transport
TST_0205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TST_0206	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TST_0207	COG0839	Belongs to the complex I subunit 6 family
TST_0211	COG1007	ATP synthesis coupled electron transport
TST_0213	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TST_0223	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TST_0230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TST_0232	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TST_0232	COG1918	ferrous iron import across plasma membrane
TST_0234	COG2226	methyltransferase
TST_0236	COG4771	TonB-dependent receptor
TST_0243	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TST_0249	COG0701	Predicted permease
TST_0251	COG2095	MarC family integral membrane protein
TST_0257	COG0438	transferase activity, transferring glycosyl groups
TST_0261	COG0457	Tetratricopeptide repeat
TST_0263	COG0529	Catalyzes the synthesis of activated sulfate
TST_0264	COG2895	sulfate adenylyltransferase (ATP) activity
TST_0265	COG0175	sulfate reduction
TST_0266	COG0529	Catalyzes the synthesis of activated sulfate
TST_0272	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TST_0278	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TST_0279	COG0505	Belongs to the CarA family
TST_0280	COG0406	alpha-ribazole phosphatase activity
TST_0281	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TST_0282	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TST_0283	COG0569	domain protein
TST_0284	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TST_0285	COG0072	phenylalanine-tRNA ligase activity
TST_0286	COG0105	UTP biosynthetic process
TST_0287	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TST_0288	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TST_0290	COG0848	biopolymer transport protein
TST_0291	COG0811	peptide transport
TST_0293	COG1047	Peptidyl-prolyl cis-trans
TST_0294	COG0733	neurotransmitter:sodium symporter activity
TST_0296	COG0585	pseudouridine synthase activity
TST_0299	COG0628	permease
TST_0301	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TST_0302	COG0574	Belongs to the PEP-utilizing enzyme family
TST_0302	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TST_0305	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TST_0306	COG0318	PFAM AMP-dependent synthetase and ligase
TST_0308	COG0632	four-way junction helicase activity
TST_0309	COG2255	four-way junction helicase activity
TST_0310	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TST_0311	COG0343	queuine tRNA-ribosyltransferase activity
TST_0312	COG3300	MHYT domain
TST_0312	COG5001	Diguanylate cyclase
TST_0313	COG0756	dUTP diphosphatase activity
TST_0315	COG3852	Histidine kinase
TST_0317	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TST_0318	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TST_0318	COG1773	rubredoxin
TST_0320	COG0438	transferase activity, transferring glycosyl groups
TST_0322	COG1216	Glycosyl transferase, family 2
TST_0322	COG0463	Glycosyl transferase, family 2
TST_0325	COG1959	2 iron, 2 sulfur cluster binding
TST_0325	COG1295	ribonuclease BN
TST_0326	COG0446	pyridine nucleotide-disulphide oxidoreductase
TST_0327	COG2239	Acts as a magnesium transporter
TST_0328	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TST_0329	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TST_0331	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TST_0332	COG0840	transmembrane signaling receptor activity
TST_0333	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TST_0334	COG1797	cobyrinic acid a,c-diamide synthase activity
TST_0336	COG2033	superoxide reductase activity
TST_0337	COG0426	domain, Protein
TST_0338	COG0450	alkyl hydroperoxide reductase
TST_0341	COG0330	HflC and HflK could
TST_0347	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TST_0348	COG0242	peptide deformylase activity
TST_0349	COG0254	rRNA binding
TST_0350	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TST_0351	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TST_0352	COG0776	regulation of translation
TST_0353	COG0658	competence protein
TST_0353	COG2333	competence protein COMEC
TST_0354	COG0180	Tryptophanyl-tRNA synthetase
TST_0355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TST_0356	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TST_0357	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TST_0358	COG0277	FAD linked oxidase domain protein
TST_0360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TST_0363	COG0443	Heat shock 70 kDa protein
TST_0365	COG0789	Transcriptional regulator
TST_0366	COG0542	response to heat
TST_0367	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TST_0372	COG4796	Type ii and iii secretion system protein
TST_0377	COG1322	Protein conserved in bacteria
TST_0379	COG0803	Belongs to the bacterial solute-binding protein 9 family
TST_0380	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TST_0381	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TST_0382	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TST_0385	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TST_0386	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TST_0387	COG1960	acyl-CoA dehydrogenase activity
TST_0388	COG0519	Catalyzes the synthesis of GMP from XMP
TST_0388	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TST_0390	COG0335	large ribosomal subunit rRNA binding
TST_0391	COG4752	Belongs to the RNA methyltransferase TrmD family
TST_0392	COG0336	Belongs to the RNA methyltransferase TrmD family
TST_0393	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TST_0394	COG1837	Belongs to the UPF0109 family
TST_0395	COG0228	four-way junction DNA binding
TST_0396	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TST_0399	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_0400	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_0401	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_0402	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_0403	COG1862	Preprotein translocase
TST_0404	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TST_0405	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TST_0408	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TST_0409	COG0242	peptide deformylase activity
TST_0410	COG2716	regulation of RNA biosynthetic process
TST_0411	COG1752	Esterase of the alpha-beta hydrolase superfamily
TST_0416	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TST_0417	COG1414	Transcriptional regulator
TST_0419	COG0530	calcium, potassium:sodium antiporter activity
TST_0421	COG0483	inositol monophosphate 1-phosphatase activity
TST_0422	COG1530	ribonuclease E activity
TST_0424	COG1136	(ABC) transporter
TST_0425	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TST_0427	COG1774	PSP1 C-terminal conserved region
TST_0428	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TST_0428	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TST_0429	COG0084	hydrolase, TatD family'
TST_0430	COG1414	Transcriptional regulator
TST_0435	COG1127	ABC transporter
TST_0436	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TST_0437	COG0509	glycine decarboxylation via glycine cleavage system
TST_0438	COG0617	tRNA 3'-terminal CCA addition
TST_0439	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TST_0442	COG1137	ATPase activity
TST_0443	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TST_0445	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TST_0445	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TST_0445	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TST_0446	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TST_0447	COG1660	Displays ATPase and GTPase activities
TST_0448	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TST_0450	COG1185	polyribonucleotide nucleotidyltransferase activity
TST_0451	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TST_0457	COG0745	RESPONSE REGULATOR receiver
TST_0458	COG5002	protein histidine kinase activity
TST_0460	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TST_0461	COG1960	acyl-CoA dehydrogenase activity
TST_0462	COG1960	acyl-CoA dehydrogenase activity
TST_0465	COG1132	(ABC) transporter
TST_0466	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TST_0468	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TST_0469	COG3494	Protein of unknown function (DUF1009)
TST_0471	COG0174	glutamine synthetase
TST_0472	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TST_0474	COG1674	ftsk spoiiie
TST_0475	COG1980	fructose-bisphosphate aldolase activity
TST_0476	COG1940	carbohydrate kinase activity
TST_0478	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TST_0479	COG1872	DUF167
TST_0481	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TST_0482	COG1388	LysM domain
TST_0482	COG0741	lytic transglycosylase activity
TST_0484	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TST_0498	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TST_0499	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TST_0500	COG1592	Rubrerythrin
TST_0503	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TST_0504	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TST_0505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TST_0506	COG1144	Oxidoreductase
TST_0509	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TST_0514	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TST_0516	COG0709	Synthesizes selenophosphate from selenide and ATP
TST_0517	COG1056	cytidyltransferase-related domain
TST_0517	COG1051	belongs to the nudix hydrolase family
TST_0518	COG1546	Belongs to the CinA family
TST_0518	COG1058	Belongs to the CinA family
TST_0519	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TST_0520	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TST_0521	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TST_0522	COG0330	HflC and HflK could
TST_0524	COG0356	it plays a direct role in the translocation of protons across the membrane
TST_0525	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TST_0527	COG0347	Belongs to the P(II) protein family
TST_0528	COG0698	ribose 5-phosphate isomerase
TST_0529	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TST_0530	COG2131	deaminase
TST_0531	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TST_0532	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TST_0533	COG4536	flavin adenine dinucleotide binding
TST_0534	COG0010	Belongs to the arginase family
TST_0535	COG1242	4 iron, 4 sulfur cluster binding
TST_0536	COG0601	transmembrane transport
TST_0537	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TST_0538	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TST_0539	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TST_0540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TST_0541	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TST_0543	COG0799	negative regulation of ribosome biogenesis
TST_0546	COG0730	response to heat
TST_0547	COG0316	Belongs to the HesB IscA family
TST_0547	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TST_0552	COG3706	GGDEF domain
TST_0554	COG2385	sporulation resulting in formation of a cellular spore
TST_0555	COG0366	Alpha amylase catalytic
TST_0555	COG3103	Sh3 type 3 domain protein
TST_0561	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TST_0563	COG3706	GGDEF domain
TST_0565	COG0752	glycyl-tRNA synthetase alpha subunit
TST_0566	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TST_0567	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TST_0570	COG0726	polysaccharide deacetylase
TST_0571	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TST_0573	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TST_0574	COG0285	dihydrofolate synthase activity
TST_0575	COG0280	phosphate acetyltransferase
TST_0575	COG0281	malic enzyme
TST_0576	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TST_0577	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TST_0579	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TST_0579	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TST_0580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TST_0581	COG1127	ABC transporter
TST_0585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TST_0589	COG1254	Belongs to the acylphosphatase family
TST_0590	COG1063	alcohol dehydrogenase
TST_0591	COG0631	protein serine/threonine phosphatase activity
TST_0592	COG1105	Belongs to the carbohydrate kinase PfkB family
TST_0593	COG1509	lysine 2,3-aminomutase activity
TST_0595	COG4786	Flagellar basal body rod
TST_0596	COG4786	Flagellar basal body rod
TST_0598	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TST_0599	COG1706	bacterial-type flagellum-dependent cell motility
TST_0604	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TST_0605	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TST_0607	COG3118	belongs to the thioredoxin family
TST_0609	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TST_0614	COG0438	transferase activity, transferring glycosyl groups
TST_0616	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TST_0617	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TST_0623	COG0728	peptidoglycan biosynthetic process
TST_0626	COG1815	bacterial-type flagellum-dependent cell motility
TST_0628	COG1677	Flagellar hook-basal body complex protein FliE
TST_0629	COG1766	The M ring may be actively involved in energy transduction
TST_0630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TST_0632	COG1157	protein secretion by the type III secretion system
TST_0637	COG1749	Flagellar hook protein flgE
TST_0640	COG1360	Flagellar Motor Protein
TST_0641	COG1580	Controls the rotational direction of flagella during chemotaxis
TST_0644	COG1338	Plays a role in the flagellum-specific transport system
TST_0645	COG1987	bacterial-type flagellum assembly
TST_0647	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TST_0648	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TST_0649	COG1419	protein localization to endoplasmic reticulum
TST_0650	COG0455	bacterial-type flagellum organization
TST_0651	COG1191	sigma factor activity
TST_0652	COG2201	protein-glutamate methylesterase activity
TST_0653	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TST_0654	COG1776	CheC inhibitor of MCP methylation
TST_0654	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TST_0655	COG1917	Cupin 2, conserved barrel domain protein
TST_0655	COG1396	sequence-specific DNA binding
TST_0656	COG0183	Belongs to the thiolase family
TST_0657	COG1250	3-hydroxyacyl-CoA dehydrogenase
TST_0658	COG1024	Enoyl-CoA hydratase
TST_0659	COG1960	acyl-CoA dehydrogenase activity
TST_0661	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TST_0662	COG2181	nitrate reductase activity
TST_0662	COG0247	lactate metabolic process
TST_0665	COG0037	tRNA processing
TST_0669	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TST_0671	COG1121	(ABC) transporter
TST_0672	COG0142	geranyltranstransferase activity
TST_0673	COG2078	PFAM AMMECR1 domain protein
TST_0675	COG0564	pseudouridine synthase activity
TST_0677	COG3706	GGDEF domain
TST_0678	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TST_0679	COG3706	GGDEF domain
TST_0679	COG0745	RESPONSE REGULATOR receiver
TST_0682	COG0436	Aminotransferase
TST_0685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TST_0686	COG1151	hydroxylamine reductase activity
TST_0688	COG1285	pathogenesis
TST_0691	COG2199	diguanylate cyclase activity
TST_0691	COG2203	Gaf domain
TST_0693	COG0720	synthase
TST_0694	COG0436	Aminotransferase
TST_0695	COG0493	'glutamate synthase
TST_0696	COG0543	2 iron, 2 sulfur cluster binding
TST_0697	COG1388	LysM domain
TST_0697	COG0741	lytic transglycosylase activity
TST_0700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TST_0701	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TST_0702	COG1418	mRNA catabolic process
TST_0703	COG1692	metallophosphoesterase
TST_0704	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TST_0705	COG1570	exodeoxyribonuclease VII activity
TST_0708	COG2875	Belongs to the precorrin methyltransferase family
TST_0710	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
TST_0712	COG1489	DNA binding
TST_0713	COG1355	regulation of microtubule-based process
TST_0718	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TST_0719	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TST_0721	COG1301	dicarboxylic acid transport
TST_0723	COG1028	Short-chain dehydrogenase reductase Sdr
TST_0726	COG0352	thiamine-phosphate diphosphorylase activity
TST_0727	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TST_0728	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TST_0735	COG3437	response regulator, receiver
TST_0746	COG1595	DNA-templated transcription, initiation
TST_0749	COG1404	Belongs to the peptidase S8 family
TST_0750	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TST_0751	COG1993	acr, cog1993
TST_0755	COG0390	transport system, permease component
TST_0763	COG3328	transposase activity
TST_0764	COG1830	Aldolase
TST_0765	COG0493	'glutamate synthase
TST_0767	COG1396	sequence-specific DNA binding
TST_0768	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TST_0770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TST_0771	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TST_0773	COG3328	transposase activity
TST_0775	COG2204	response regulator
TST_0776	COG4191	Histidine kinase
TST_0777	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_0778	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_0781	COG0113	porphobilinogen synthase activity
TST_0787	COG2009	succinate dehydrogenase
TST_0790	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TST_0791	COG0045	succinate-CoA ligase (ADP-forming) activity
TST_0792	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TST_0794	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TST_0794	COG0674	pyruvate-flavodoxin oxidoreductase activity
TST_0795	COG1013	pyruvate-flavodoxin oxidoreductase activity
TST_0797	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
TST_0798	COG0481	GTPase activity
TST_0799	COG0681	Belongs to the peptidase S26 family
TST_0805	COG1475	DNA binding
TST_0806	COG1979	alcohol dehydrogenase
TST_0808	COG1110	DNA topoisomerase II activity
TST_0809	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TST_0812	COG0602	queuosine metabolic process
TST_0813	COG0210	DNA helicase
TST_0817	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TST_0819	COG0860	N-Acetylmuramoyl-L-alanine amidase
TST_0820	COG0196	riboflavin kinase activity
TST_0821	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TST_0822	COG1959	2 iron, 2 sulfur cluster binding
TST_0823	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TST_0825	COG0643	Histidine kinase
TST_0825	COG2198	Histidine kinase
TST_0826	COG0835	chemotaxis
TST_0827	COG0784	Response regulator, receiver
TST_0827	COG0835	chemotaxis
TST_0828	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TST_0829	COG0606	chelatase, subunit chli
TST_0831	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TST_0832	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TST_0833	COG0438	transferase activity, transferring glycosyl groups
TST_0838	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TST_0839	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TST_0840	COG0124	histidyl-tRNA synthetase
TST_0843	COG1024	Enoyl-CoA hydratase
TST_0849	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TST_0849	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TST_0850	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TST_0851	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TST_0852	COG1067	ATP-dependent peptidase activity
TST_0853	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TST_0855	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TST_0856	COG0785	Cytochrome C biogenesis protein
TST_0857	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TST_0859	COG0215	cysteine-tRNA ligase activity
TST_0861	COG0432	Pfam Uncharacterised protein family UPF0047
TST_0862	COG3956	TIGRFAM MazG family protein
TST_0865	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TST_0867	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TST_0868	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TST_0869	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TST_0870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TST_0871	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TST_0872	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TST_0873	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TST_0874	COG1475	DNA binding
TST_0875	COG1192	Involved in chromosome partitioning
TST_0877	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TST_0878	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TST_0879	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TST_0880	COG0540	Belongs to the ATCase OTCase family
TST_0881	COG0802	atpase or kinase
TST_0882	COG0109	protoheme IX farnesyltransferase activity
TST_0884	COG1213	nucleotidyl transferase
TST_0884	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TST_0885	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TST_0888	COG1968	undecaprenyl-diphosphatase activity
TST_0892	COG0793	Belongs to the peptidase S41A family
TST_0893	COG1605	Chorismate mutase
TST_0893	COG0077	Prephenate dehydratase
TST_0894	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TST_0895	COG0149	triose-phosphate isomerase activity
TST_0896	COG0126	phosphoglycerate kinase activity
TST_0898	COG0124	histidyl-tRNA synthetase
TST_0899	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TST_0901	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TST_0904	COG0784	Response regulator, receiver
TST_0904	COG3437	response regulator, receiver
TST_0907	COG1193	negative regulation of DNA recombination
TST_0908	COG1610	YqeY-like protein
TST_0910	COG0138	bifunctional purine biosynthesis protein purh
TST_0912	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TST_0913	COG0517	IMP dehydrogenase activity
TST_0913	COG0516	GMP reductase activity
TST_0914	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TST_0918	COG0446	pyridine nucleotide-disulphide oxidoreductase
TST_0922	COG0444	Belongs to the ABC transporter superfamily
TST_0926	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TST_0928	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TST_0930	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TST_0931	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TST_0933	COG2204	response regulator
TST_0934	COG4191	Histidine kinase
TST_0935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TST_0940	COG0307	riboflavin synthase, alpha
TST_0941	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TST_0943	COG1792	Involved in formation and maintenance of cell shape
TST_0945	COG0463	Glycosyl transferase, family 2
TST_0947	COG0583	DNA-binding transcription factor activity
TST_0949	COG1921	L-seryl-tRNASec selenium transferase activity
TST_0950	COG1024	Enoyl-CoA hydratase
TST_0951	COG1250	3-hydroxyacyl-CoA dehydrogenase
TST_0952	COG3706	GGDEF domain
TST_0953	COG4251	negative regulation of phosphorylation
TST_0953	COG2203	Gaf domain
TST_0953	COG3706	GGDEF domain
TST_0953	COG5001	Diguanylate cyclase
TST_0954	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TST_0956	COG3328	transposase activity
TST_0961	COG0792	nuclease activity
TST_0962	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TST_0963	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TST_0964	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TST_0965	COG0210	DNA helicase
TST_0966	COG0038	chloride channel
TST_0967	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TST_0968	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TST_0969	COG1024	Enoyl-CoA hydratase
TST_0970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TST_0971	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TST_0972	COG0009	L-threonylcarbamoyladenylate synthase
TST_0973	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TST_0974	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TST_0975	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TST_0976	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TST_0977	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TST_0978	COG0165	Argininosuccinate lyase
TST_0978	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TST_0979	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TST_0981	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TST_0981	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TST_0982	COG0237	dephospho-CoA kinase activity
TST_0984	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TST_0985	COG0735	belongs to the Fur family
TST_0990	COG3328	transposase activity
TST_0993	COG2197	response regulator
TST_0998	COG1462	curli production assembly transport component CsgG
TST_0999	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TST_1000	COG1324	tolerance protein
TST_1001	COG0674	pyruvate-flavodoxin oxidoreductase activity
TST_1002	COG1013	pyruvate-flavodoxin oxidoreductase activity
TST_1003	COG2267	carboxylic ester hydrolase activity
TST_1006	COG0525	valine-tRNA ligase activity
TST_1007	COG1663	tetraacyldisaccharide 4'-kinase activity
TST_1008	COG0768	penicillin binding
TST_1009	COG0772	Belongs to the SEDS family
TST_1010	COG0424	maF-like protein
TST_1011	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TST_1011	COG0758	DNA mediated transformation
TST_1012	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TST_1014	COG0497	DNA recombination
TST_1017	COG0751	glycine-tRNA ligase activity
TST_1023	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
TST_1024	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
TST_1025	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TST_1026	COG1024	Enoyl-CoA hydratase
TST_1028	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TST_1029	COG1518	maintenance of DNA repeat elements
TST_1038	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TST_1040	COG0741	lytic transglycosylase activity
TST_1041	COG0552	protein localization to endoplasmic reticulum
TST_1042	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TST_1044	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TST_1047	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TST_1048	COG1181	Belongs to the D-alanine--D-alanine ligase family
TST_1049	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TST_1050	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TST_1051	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TST_1052	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TST_1053	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TST_1056	COG0275	rRNA processing
TST_1057	COG0494	nUDIX hydrolase
TST_1060	COG2204	response regulator
TST_1061	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TST_1062	COG0668	transmembrane transport
TST_1063	COG0183	Belongs to the thiolase family
TST_1065	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TST_1066	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TST_1067	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TST_1068	COG0019	diaminopimelate decarboxylase activity
TST_1070	COG0165	Argininosuccinate lyase
TST_1072	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TST_1073	COG0674	pyruvate-flavodoxin oxidoreductase activity
TST_1074	COG1013	pyruvate-flavodoxin oxidoreductase activity
TST_1075	COG5001	Diguanylate cyclase
TST_1075	COG1716	ATPase activity
TST_1076	COG2050	protein possibly involved in aromatic compounds catabolism
TST_1079	COG1074	ATP-dependent DNA helicase activity
TST_1080	COG1830	Aldolase
TST_1081	COG1465	3-dehydroquinate synthase
TST_1083	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TST_1084	COG2814	Major facilitator Superfamily
TST_1085	COG1566	PFAM secretion protein HlyD family protein
TST_1087	COG1309	transcriptional regulator
TST_1089	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TST_1089	COG0045	succinate-CoA ligase (ADP-forming) activity
TST_1089	COG1042	CoA-binding domain protein
TST_1090	COG1309	transcriptional regulator
TST_1092	COG3328	transposase activity
TST_1093	COG0101	tRNA pseudouridine synthase activity
TST_1094	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TST_1095	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TST_1096	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TST_1099	COG0778	Nitroreductase
TST_1102	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TST_1103	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TST_1104	COG0167	dihydroorotate dehydrogenase activity
TST_1107	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TST_1109	COG2361	Protein of unknown function DUF86
TST_1112	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TST_1112	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TST_1115	COG5001	Diguanylate cyclase
TST_1116	COG0495	leucyl-tRNA aminoacylation
TST_1118	COG0840	transmembrane signaling receptor activity
TST_1119	COG3300	MHYT domain
TST_1119	COG5001	Diguanylate cyclase
TST_1121	COG1420	regulation of RNA biosynthetic process
TST_1122	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TST_1123	COG0484	heat shock protein binding
TST_1126	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TST_1136	COG1210	Utp--glucose-1-phosphate uridylyltransferase
TST_1140	COG1122	ATPase activity
TST_1143	COG0310	cobalt ion transport
TST_1144	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
TST_1145	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
TST_1146	COG5557	Pfam Polysulphide reductase, NrfD
TST_1147	COG0437	4 iron, 4 sulfur cluster binding
TST_1148	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
TST_1149	COG0805	protein transport
TST_1150	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TST_1151	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
TST_1152	COG0375	protein maturation
TST_1154	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
TST_1156	COG0309	Hydrogenase expression formation protein (HypE)
TST_1157	COG2186	Transcriptional regulator
TST_1158	COG1346	cytolysis
TST_1162	COG3328	transposase activity
TST_1164	COG2361	Protein of unknown function DUF86
TST_1166	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TST_1168	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TST_1170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TST_1171	COG0778	Nitroreductase
TST_1172	COG1917	Cupin 2, conserved barrel domain protein
TST_1172	COG1396	sequence-specific DNA binding
TST_1175	COG1773	rubredoxin
TST_1177	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TST_1181	COG1490	D-aminoacyl-tRNA deacylase activity
TST_1182	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TST_1185	COG0840	transmembrane signaling receptor activity
TST_1189	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TST_1190	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TST_1191	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TST_1192	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TST_1194	COG0268	Binds directly to 16S ribosomal RNA
TST_1196	COG0459	protein refolding
TST_1197	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TST_1202	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_1203	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_1205	COG1543	Belongs to the glycosyl hydrolase 57 family
TST_1208	COG1449	Belongs to the glycosyl hydrolase 57 family
TST_1210	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TST_1211	COG1090	epimerase
TST_1213	COG3328	transposase activity
TST_1216	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TST_1217	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TST_1219	COG0517	IMP dehydrogenase activity
TST_1219	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TST_1220	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TST_1221	COG0504	CTP synthase activity
TST_1222	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TST_1224	COG0708	Exodeoxyribonuclease III
TST_1225	COG0745	RESPONSE REGULATOR receiver
TST_1226	COG5002	protein histidine kinase activity
TST_1236	COG3706	GGDEF domain
TST_1237	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TST_1237	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TST_1238	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TST_1239	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TST_1240	COG1160	GTP binding
TST_1241	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TST_1243	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TST_1244	COG0740	serine-type endopeptidase activity
TST_1246	COG2814	Major facilitator Superfamily
TST_1248	COG0842	Transport permease protein
TST_1248	COG1129	ABC transporter
TST_1249	COG1131	(ABC) transporter
TST_1250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TST_1251	COG1566	PFAM secretion protein HlyD family protein
TST_1253	COG1309	transcriptional regulator
TST_1259	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TST_1260	COG0527	aspartate kinase activity
TST_1261	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TST_1262	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TST_1263	COG0492	ferredoxin-NADP+ reductase activity
TST_1265	COG0456	acetyltransferase
TST_1266	COG0156	8-amino-7-oxononanoate synthase activity
TST_1267	COG0012	GTP binding
TST_1268	COG1183	phosphatidylcholine synthase activity
TST_1269	COG0688	phosphatidylethanolamine metabolic process
TST_1270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TST_1271	COG0440	acetolactate synthase activity
TST_1272	COG0028	Belongs to the TPP enzyme family
TST_1273	COG0129	dihydroxy-acid dehydratase activity
TST_1276	COG1214	PFAM Peptidase M22, glycoprotease
TST_1279	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TST_1280	COG0157	Belongs to the NadC ModD family
TST_1292	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TST_1292	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TST_1294	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
TST_1295	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TST_1296	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TST_1299	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TST_1301	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
TST_1305	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TST_1306	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TST_1309	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TST_1309	COG1796	DNA polymerase
TST_1316	COG0789	Transcriptional regulator
TST_1319	COG0489	protein tyrosine kinase activity
TST_1320	COG0489	protein tyrosine kinase activity
TST_1323	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TST_1324	COG0571	ribonuclease III activity
TST_1325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TST_1326	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TST_1327	COG1028	Short-chain dehydrogenase reductase Sdr
TST_1328	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TST_1330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TST_1331	COG0416	fatty acid biosynthetic process
TST_1332	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TST_1337	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TST_1339	COG1469	GTP cyclohydrolase I activity
TST_1340	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TST_1341	COG4608	Belongs to the ABC transporter superfamily
TST_1342	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TST_1345	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TST_1345	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TST_1346	COG1515	deoxyribonuclease V activity
TST_1347	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TST_1348	COG1100	Small GTP-binding protein
TST_1353	COG1028	Short-chain dehydrogenase reductase Sdr
TST_1354	COG2116	formate transmembrane transporter activity
TST_1355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TST_1356	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TST_1357	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TST_1358	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TST_1360	COG1519	Transferase
TST_1361	COG0346	lactoylglutathione lyase activity
TST_1364	COG5016	pyruvate
TST_1364	COG0511	ligase activity, forming carbon-carbon bonds
TST_1365	COG0439	Biotin carboxylase
TST_1366	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TST_1368	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TST_1369	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TST_1371	COG2885	chlorophyll binding
TST_1374	COG0438	transferase activity, transferring glycosyl groups
TST_1376	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
TST_1378	COG1136	(ABC) transporter
TST_1378	COG0577	efflux transmembrane transporter activity
TST_1380	COG1136	(ABC) transporter
TST_1380	COG0577	efflux transmembrane transporter activity
TST_1381	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TST_1384	COG0137	argininosuccinate synthase activity
TST_1390	COG0166	Belongs to the GPI family
TST_1391	COG0556	nucleotide-excision repair
TST_1400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TST_1402	COG1702	phosphate starvation-inducible protein PhoH
TST_1403	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TST_1404	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TST_1405	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TST_1406	COG0203	ribosomal protein L17
TST_1407	COG0202	RNA polymerase activity
TST_1408	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TST_1409	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TST_1410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TST_1411	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TST_1412	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TST_1413	COG0024	Methionine aminopeptidase
TST_1414	COG0563	adenylate kinase activity
TST_1415	COG0201	protein transport
TST_1416	COG0200	Binds to the 23S rRNA
TST_1417	COG1841	ribosomal large subunit assembly
TST_1418	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TST_1419	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TST_1420	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TST_1421	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TST_1422	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TST_1423	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TST_1424	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TST_1425	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TST_1427	COG0255	Belongs to the universal ribosomal protein uL29 family
TST_1428	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TST_1429	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TST_1430	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TST_1431	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TST_1432	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TST_1433	COG0089	rRNA binding
TST_1434	COG0088	Forms part of the polypeptide exit tunnel
TST_1435	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TST_1436	COG0051	transcription antitermination factor activity, RNA binding
TST_1437	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TST_1438	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TST_1439	COG0049	tRNA binding
TST_1440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TST_1441	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TST_1442	COG0085	RNA polymerase activity
TST_1443	COG0222	ribosome binding
TST_1445	COG0081	regulation of translation
TST_1446	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TST_1447	COG0250	Participates in transcription elongation, termination and antitermination
TST_1449	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TST_1450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TST_1453	COG0584	glycerophosphoryl diester phosphodiesterase
TST_1455	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TST_1456	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TST_1456	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TST_1458	COG0011	TIGRFAM Protein of
TST_1459	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TST_1461	COG1918	ferrous iron import across plasma membrane
TST_1461	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TST_1465	COG0513	Belongs to the DEAD box helicase family
TST_1470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TST_1471	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TST_1473	COG2089	acid synthase
TST_1474	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TST_1475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TST_1477	COG0277	FAD linked oxidase domain protein
TST_1481	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TST_1482	COG0575	Belongs to the CDS family
TST_1483	COG0473	3-isopropylmalate dehydrogenase activity
TST_1484	COG0066	3-isopropylmalate dehydratase activity
TST_1485	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TST_1486	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TST_1488	COG0159	tryptophan synthase activity
TST_1489	COG0133	tryptophan synthase activity
TST_1490	COG0135	phosphoribosylanthranilate isomerase activity
TST_1491	COG0134	indole-3-glycerol-phosphate synthase activity
TST_1492	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TST_1502	COG1007	ATP synthesis coupled electron transport
TST_1504	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TST_1505	COG0713	ATP synthesis coupled electron transport
TST_1506	COG0839	Belongs to the complex I subunit 6 family
TST_1507	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TST_1508	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TST_1510	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TST_1511	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TST_1512	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TST_1514	COG1611	Belongs to the LOG family
TST_1516	COG0730	response to heat
TST_1525	COG0840	transmembrane signaling receptor activity
TST_1526	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TST_1527	COG1648	precorrin-2 dehydrogenase activity
TST_1527	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TST_1529	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TST_1530	COG1030	water channel activity
TST_1533	COG0616	signal peptide processing
TST_1534	COG0539	negative regulation of cytoplasmic translation
TST_1535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TST_1536	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TST_1539	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TST_1541	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TST_1544	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TST_1549	COG1492	cobalamin metabolic process
TST_1550	COG1584	GPR1 FUN34 yaaH family protein
TST_1554	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TST_1554	COG1042	CoA-binding domain protein
TST_1554	COG0045	succinate-CoA ligase (ADP-forming) activity
TST_1555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TST_1555	COG0574	Belongs to the PEP-utilizing enzyme family
TST_1558	COG0542	response to heat
TST_1559	COG0297	glycogen (starch) synthase activity
TST_1560	COG0058	SHG alpha-glucan phosphorylase activity
TST_1561	COG0156	8-amino-7-oxononanoate synthase activity
TST_1564	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TST_1566	COG1509	lysine 2,3-aminomutase activity
TST_1570	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TST_1571	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TST_1572	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TST_1574	COG1618	nucleotide phosphatase activity, acting on free nucleotides
TST_1576	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TST_1580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TST_1581	COG1024	Enoyl-CoA hydratase
TST_1582	COG0511	ligase activity, forming carbon-carbon bonds
TST_1583	COG0439	Biotin carboxylase
TST_1585	COG3300	MHYT domain
TST_1585	COG5001	Diguanylate cyclase
TST_1587	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TST_1592	COG2119	membrane
TST_1598	COG1959	2 iron, 2 sulfur cluster binding
TST_1602	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TST_1603	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TST_1605	COG0037	tRNA processing
TST_1612	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TST_1613	COG0798	PFAM Bile acid sodium symporter
TST_1618	COG0193	aminoacyl-tRNA hydrolase activity
TST_1619	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TST_1620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TST_1621	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TST_1627	COG0347	Belongs to the P(II) protein family
TST_1630	COG1459	type II secretion system
TST_1633	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TST_1636	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TST_1637	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TST_1638	COG0052	Belongs to the universal ribosomal protein uS2 family
TST_1639	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TST_1640	COG0528	UMP kinase activity
TST_1641	COG0233	cytoplasmic translational termination
TST_1643	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TST_1645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TST_1646	COG2835	tetraacyldisaccharide 4'-kinase activity
TST_1647	COG2823	Periplasmic or secreted lipoprotein
TST_1647	COG1652	LysM domain
TST_1649	COG0442	prolyl-tRNA aminoacylation
TST_1650	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TST_1654	COG0559	Belongs to the binding-protein-dependent transport system permease family
TST_1656	COG0351	phosphomethylpyrimidine kinase
TST_1660	COG1966	Carbon starvation protein
TST_1662	COG0859	PFAM glycosyl transferase family 9
TST_1663	COG0439	Biotin carboxylase
TST_1664	COG0511	ligase activity, forming carbon-carbon bonds
TST_1665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TST_1666	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TST_1667	COG0629	single-stranded DNA binding
TST_1668	COG0360	Binds together with S18 to 16S ribosomal RNA
TST_1670	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TST_1671	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TST_1673	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TST_1674	COG0542	response to heat
TST_1675	COG0402	S-adenosylhomocysteine deaminase activity
TST_1676	COG0612	Peptidase, M16
TST_1677	COG0612	Peptidase, M16
TST_1678	COG1187	pseudouridine synthase activity
TST_1679	COG0047	phosphoribosylformylglycinamidine synthase activity
TST_1681	COG0235	Class ii aldolase
TST_1686	COG0823	Involved in the tonB-independent uptake of proteins
TST_1690	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TST_1692	COG0585	pseudouridine synthase activity
TST_1693	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TST_1694	COG0107	imidazoleglycerol-phosphate synthase activity
TST_1695	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TST_1698	COG2197	response regulator
TST_1700	COG2197	response regulator
TST_1702	COG0587	DNA-directed DNA polymerase activity
TST_1703	COG0825	malonyl-CoA metabolic process
TST_1704	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
TST_1705	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
TST_1710	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TST_1710	COG0731	radical SAM domain protein
TST_1711	COG2070	2-Nitropropane dioxygenase
TST_1714	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TST_1715	COG0131	Imidazoleglycerol-phosphate dehydratase
TST_1717	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TST_1719	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TST_1720	COG0142	geranyltranstransferase activity
TST_1722	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TST_1722	COG0140	phosphoribosyl-ATP diphosphatase activity
TST_1723	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TST_1727	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TST_1728	COG0305	Participates in initiation and elongation during chromosome replication
TST_1729	COG0359	binds to the 23S rRNA
TST_1730	COG0840	transmembrane signaling receptor activity
TST_1731	COG0347	Belongs to the P(II) protein family
TST_1733	COG1139	Iron-sulfur cluster binding protein
TST_1734	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TST_1735	COG3300	MHYT domain
TST_1735	COG5001	Diguanylate cyclase
TST_1737	COG0284	orotidine-5'-phosphate decarboxylase activity
TST_1738	COG1410	methionine synthase
TST_1738	COG0646	methionine synthase
TST_1743	COG1058	Belongs to the CinA family
TST_1743	COG1546	Belongs to the CinA family
TST_1746	COG0406	alpha-ribazole phosphatase activity
TST_1746	COG0328	RNA-DNA hybrid ribonuclease activity
TST_1747	COG0018	arginyl-trna synthetase
TST_1751	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TST_1752	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TST_1753	COG2890	protein-(glutamine-N5) methyltransferase activity
TST_1754	COG0436	Aminotransferase
TST_1757	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TST_1758	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TST_1760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TST_1763	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TST_1764	COG2264	protein methyltransferase activity
TST_1765	COG0647	UMP catabolic process
TST_1767	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TST_1768	COG0537	adenosine 5'-monophosphoramidase activity
TST_1771	COG1573	uracil-dna glycosylase
TST_1773	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TST_1773	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TST_1774	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TST_1776	COG0586	Pfam SNARE associated Golgi protein
TST_1777	COG0179	Fumarylacetoacetate (FAA) hydrolase
TST_1778	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TST_1779	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TST_1780	COG0181	hydroxymethylbilane synthase activity
TST_1781	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TST_1781	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TST_1782	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TST_1783	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TST_1784	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase