locus-tag class description COG2360 Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine COG0825 malonyl-CoA metabolic process COG0511 ligase activity, forming carbon-carbon bonds COG0439 Biotin carboxylase COG0777 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis COG0013 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain COG0237 dephospho-CoA kinase activity COG0448 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans COG0548 Belongs to the acetylglutamate kinase family. ArgB subfamily COG0002 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde COG4992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity COG0078 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline COG0137 argininosuccinate synthase activity COG0165 Argininosuccinate lyase COG1364 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate COG0018 arginyl-trna synthetase COG0128 3-phosphoshikimate 1-carboxyvinyltransferase activity COG0337 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) COG0082 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system COG0169 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) COG0703 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate COG0757 Catalyzes a trans-dehydration via an enolate intermediate COG0136 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate COG0017 Asparaginyl-tRNA synthetase COG0436 Aminotransferase COG0173 Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) COG0056 Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit COG0055 Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits COG0224 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex COG0712 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation COG0355 proton-transporting ATP synthase activity, rotational mechanism COG0711 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) COG0711 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) COG0636 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation COG0356 it plays a direct role in the translocation of protons across the membrane COG0502 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism COG0156 8-amino-7-oxononanoate synthase activity COG0434 BtpA family COG2876 3-deoxy-7-phosphoheptulonate synthase activity COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein COG4576 ethanolamine utilization protein EutN carboxysome structural protein Ccml COG0663 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily COG4451 ribulose bisphosphate carboxylase, small COG0663 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily COG1333 cytochrome c biogenesis protein COG0755 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes COG0575 Belongs to the CDS family COG2710 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein COG1239 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX COG1240 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX COG0382 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate COG1429 ligase activity, forming nitrogen-metal bonds COG1239 Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX COG1348 The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein COG2227 3-demethylubiquinone-9 3-O-methyltransferase activity COG2710 Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein COG0644 oxidoreductase COG0542 response to heat COG0542 response to heat COG0740 serine-type endopeptidase activity COG0740 serine-type endopeptidase activity COG0740 serine-type endopeptidase activity COG1219 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP COG0715 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component COG0715 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components COG1116 anion transmembrane transporter activity COG1116 anion transmembrane transporter activity COG0007 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme COG1797 cobyrinic acid a,c-diamide synthase activity COG1270 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group COG2082 Precorrin-8x methylmutase COG1492 cobalamin metabolic process COG0237 dephospho-CoA kinase activity COG0369 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component COG1413 lyase activity COG1413 lyase activity COG0448 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans COG0448 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans COG0237 dephospho-CoA kinase activity COG1691 (AIR) carboxylase COG3349 Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7' COG0109 protoheme IX farnesyltransferase activity COG0793 Belongs to the peptidase S41A family COG0793 Belongs to the peptidase S41A family COG1271 oxidase subunit COG1294 oxidase, subunit COG1118 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system COG0529 Catalyzes the synthesis of activated sulfate COG0529 Catalyzes the synthesis of activated sulfate COG1045 serine acetyltransferase COG0175 sulfate reduction COG0031 Belongs to the cysteine synthase cystathionine beta- synthase family COG0215 cysteine-tRNA ligase activity COG0555 PFAM binding-protein-dependent transport systems inner membrane component COG4208 sulfate ABC transporter COG2010 Cytochrome c COG0329 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) COG0289 4-hydroxy-tetrahydrodipicolinate reductase COG0253 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan COG0593 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids COG0305 Participates in initiation and elongation during chromosome replication COG1372 Participates in initiation and elongation during chromosome replication COG0305 Participates in initiation and elongation during chromosome replication COG1372 Participates in initiation and elongation during chromosome replication COG0587 DNA-directed DNA polymerase activity COG0587 DNA-directed DNA polymerase activity COG0358 DNA primase activity COG0484 heat shock protein binding COG0484 heat shock protein binding COG0484 heat shock protein binding COG0484 heat shock protein binding COG0443 Heat shock 70 kDa protein COG0443 Heat shock 70 kDa protein COG0443 Heat shock 70 kDa protein COG0592 DNA-directed DNA polymerase activity COG0470 DNA polymerase III COG0783 Belongs to the Dps family COG0231 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase COG0331 [acyl-carrier-protein] S-malonyltransferase activity COG0332 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids COG1494 fructose-1,6-bisphosphatase COG0158 D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 COG0370 Transporter of a GTP-driven Fe(2 ) uptake system COG0541 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY COG0223 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus COG0285 dihydrofolate synthase activity COG0190 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate COG0302 gtp cyclohydrolase COG0801 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0294 Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives COG0266 class I DNA-(apurinic or apyrimidinic site) endonuclease activity COG4802 Ferredoxin thioredoxin reductase catalytic beta chain COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG0772 Belongs to the SEDS family COG0552 protein localization to endoplasmic reticulum COG0206 Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity COG0735 belongs to the Fur family COG0480 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome COG0480 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome COG0057 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity COG0357 Ribosomal RNA small subunit methyltransferase G COG0277 FAD linked oxidase domain protein COG0277 FAD linked oxidase domain protein COG0371 Dehydrogenase COG0297 glycogen (starch) synthase activity COG0296 Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position COG0449 glutamine-fructose-6-phosphate transaminase (isomerizing) activity COG0174 glutamine synthetase COG0067 glutamate synthase COG0069 glutamate synthase activity COG0070 glutamate synthase COG0008 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) COG0752 glycyl-tRNA synthetase alpha subunit COG0751 glycine-tRNA ligase activity COG0459 protein refolding COG0459 protein refolding COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter COG0576 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0189 ligase activity COG0518 GMP synthase (glutamine-hydrolyzing) activity COG0519 Catalyzes the synthesis of GMP from XMP COG0112 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism COG0188 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner COG0188 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner COG0187 DNA topoisomerase II activity COG1372 Participates in initiation and elongation during chromosome replication COG0373 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) COG0113 porphobilinogen synthase activity COG0181 hydroxymethylbilane synthase activity COG1587 Uroporphyrinogen-III synthase COG0407 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III COG0408 coproporphyrinogen oxidase activity COG2890 protein-(glutamine-N5) methyltransferase activity COG0276 Catalyzes the ferrous insertion into protoporphyrin IX COG0001 glutamate-1-semialdehyde 2,1-aminomutase activity COG0635 Involved in the biosynthesis of porphyrin-containing compound COG0106 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase COG0131 Imidazoleglycerol-phosphate dehydratase COG0141 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine COG0107 imidazoleglycerol-phosphate synthase activity COG0040 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity COG0118 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR COG0139 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP COG0140 phosphoribosyl-ATP diphosphatase activity COG0124 histidyl-tRNA synthetase COG5398 heme oxygenase COG5398 heme oxygenase COG1281 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress COG0071 Belongs to the small heat shock protein (HSP20) family COG0060 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) COG0059 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate COG0129 dihydroxy-acid dehydratase activity COG0028 Belongs to the TPP enzyme family COG0440 acetolactate synthase activity COG0361 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex COG0290 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins COG0119 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) COG0473 3-isopropylmalate dehydrogenase activity COG0065 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate COG0495 leucyl-tRNA aminoacylation COG0272 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA COG1544 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase COG0019 diaminopimelate decarboxylase activity COG1190 Belongs to the class-II aminoacyl-tRNA synthetase family COG1575 Belongs to the MenA family. Type 1 subfamily COG1165 Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) COG0318 PFAM AMP-dependent synthetase and ligase COG0646 methionine synthase COG1410 methionine synthase COG0143 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0850 regulation of cytokinetic process COG2894 cell division COG0851 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell COG2896 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate COG0315 cyclic pyranopterin monophosphate synthase activity COG0746 molybdenum cofactor guanylyltransferase activity COG0314 molybdopterin synthase activity COG0303 'Molybdopterin COG0773 UDP-N-acetylmuramate-L-alanine ligase activity COG0771 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) COG0769 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan COG0770 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity COG0707 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) COG0766 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine COG0323 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex COG1193 negative regulation of DNA recombination COG0379 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate COG0029 Catalyzes the oxidation of L-aspartate to iminoaspartate COG0157 Belongs to the NadC ModD family COG0243 molybdopterin cofactor binding COG1252 NADH dehydrogenase COG1005 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone COG1007 ATP synthesis coupled electron transport COG0838 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1008 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1008 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1008 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1008 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0651 ATP synthesis coupled electron transport COG0713 ATP synthesis coupled electron transport COG1009 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit COG1009 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit COG1009 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit COG0839 Belongs to the complex I subunit 6 family COG0649 NAD binding COG1143 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0852 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0377 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1104 cysteine desulfurase activity COG1104 cysteine desulfurase activity COG0520 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine COG0155 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family COG0715 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components COG0600 ABC-type nitrate sulfonate bicarbonate transport system permease component COG0715 COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components COG1116 anion transmembrane transporter activity COG1116 anion transmembrane transporter activity COG0664 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein COG0583 DNA-binding transcription factor activity COG0250 Participates in transcription elongation, termination and antitermination COG3409 Peptidoglycan-binding domain 1 protein COG3429 Glucose-6-phosphate dehydrogenase subunit COG0413 3-methyl-2-oxobutanoate hydroxymethyltransferase activity COG0283 belongs to the cytidylate kinase family. Type 1 subfamily COG0414 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate COG0493 'glutamate synthase COG3349 Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7' COG1995 Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) COG0259 pyridoxamine-phosphate oxidase activity COG0854 Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate COG1018 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress COG0369 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component COG2010 Cytochrome c COG0126 phosphoglycerate kinase activity COG0016 Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily COG0072 phenylalanine-tRNA ligase activity COG0073 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0415 Belongs to the DNA photolyase family COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB COG0416 fatty acid biosynthetic process COG0258 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity COG0749 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity COG1028 Short-chain dehydrogenase reductase Sdr COG0221 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions COG2352 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle COG0855 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) COG0216 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA COG1186 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA COG0572 uridine kinase COG0014 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate COG0263 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate COG0345 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline COG0442 prolyl-tRNA aminoacylation COG2885 chlorophyll binding COG2885 chlorophyll binding COG1143 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1555 photosystem II stabilization COG2010 Cytochrome c COG0193 aminoacyl-tRNA hydrolase activity COG0104 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP COG0015 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily COG0152 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity COG0151 Belongs to the GarS family COG0041 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) COG0034 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine COG0138 bifunctional purine biosynthesis protein purh COG0026 Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) COG0046 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL COG0047 phosphoribosylformylglycinamidine synthase activity COG0150 phosphoribosylformylglycinamidine cyclo-ligase activity COG0299 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate COG0788 formyltetrahydrofolate deformylase activity COG1012 belongs to the aldehyde dehydrogenase family COG0458 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity COG0540 Belongs to the ATCase OTCase family COG0044 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides COG0167 dihydroorotate dehydrogenase activity COG0284 orotidine-5'-phosphate decarboxylase activity COG0504 CTP synthase activity COG0528 UMP kinase activity COG1562 ergosterol biosynthetic process COG1066 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function COG2003 Belongs to the UPF0758 family COG1850 ribulose-bisphosphate carboxylase activity COG4451 ribulose bisphosphate carboxylase, small COG0468 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage COG1195 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP COG1200 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) COG0608 single-stranded DNA 5'-3' exodeoxyribonuclease activity COG4199 Single-strand DNA-specific exonuclease, C terminal domain COG0608 single-stranded DNA 5'-3' exodeoxyribonuclease activity COG4199 Single-strand DNA-specific exonuclease, C terminal domain COG0514 ATP-dependent DNA helicase (RecQ) COG0353 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO COG0451 ADP-glyceromanno-heptose 6-epimerase activity COG1091 dTDP-4-dehydrorhamnose reductase activity COG0164 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids COG0108 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate COG0807 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate COG0117 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate COG1985 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate COG0196 riboflavin kinase activity COG0054 6,7-dimethyl-8-ribityllumazine synthase activity COG1530 ribonuclease E activity COG0328 RNA-DNA hybrid ribonuclease activity COG0036 Belongs to the ribulose-phosphate 3-epimerase family COG0120 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate COG0081 regulation of translation COG0244 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors COG0080 Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors COG0222 ribosome binding COG0102 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly COG0093 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome COG0200 Binds to the 23S rRNA COG0197 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs COG0203 ribosomal protein L17 COG0256 This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance COG0335 large ribosomal subunit rRNA binding COG0090 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0292 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit COG0261 This protein binds to 23S rRNA in the presence of protein L20 COG0091 The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome COG0089 rRNA binding COG0198 One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit COG1825 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance COG0211 Belongs to the bacterial ribosomal protein bL27 family COG0227 Belongs to the bacterial ribosomal protein bL28 family COG0255 Belongs to the universal ribosomal protein uL29 family COG0087 One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit COG0254 rRNA binding COG0333 Belongs to the bacterial ribosomal protein bL32 family COG0267 Belongs to the bacterial ribosomal protein bL33 family COG0230 Belongs to the bacterial ribosomal protein bL34 family COG0291 Belongs to the bacterial ribosomal protein bL35 family COG0257 Belongs to the bacterial ribosomal protein bL36 family COG0088 Forms part of the polypeptide exit tunnel COG0094 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits COG0097 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center COG0359 binds to the 23S rRNA COG0202 RNA polymerase activity COG0085 RNA polymerase activity COG0086 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates COG0086 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates COG0539 negative regulation of cytoplasmic translation COG0051 transcription antitermination factor activity, RNA binding COG0100 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome COG0048 Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit COG0099 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0199 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site COG0184 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome COG0228 four-way junction DNA binding COG0186 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA COG0238 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit COG0185 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA COG0052 Belongs to the universal ribosomal protein uS2 family COG0268 Binds directly to 16S ribosomal RNA COG0828 Belongs to the bacterial ribosomal protein bS21 family COG0092 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation COG0522 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit COG0098 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body COG0360 Binds together with S18 to 16S ribosomal RNA COG0049 tRNA binding COG0096 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit COG0103 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) COG0233 cytoplasmic translational termination COG1773 rubredoxin COG0632 four-way junction helicase activity COG2255 four-way junction helicase activity COG0817 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group COG1613 Sulfate ABC transporter periplasmic sulfate-binding protein COG0142 geranyltranstransferase activity COG0653 protein targeting COG0342 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA COG0341 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA COG0201 protein transport COG0111 D-isomer specific 2-hydroxyacid dehydrogenase COG0172 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) COG1657 PFAM Prenyltransferase squalene oxidase COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released COG1191 sigma factor activity COG1595 DNA-templated transcription, initiation COG1595 DNA-templated transcription, initiation COG0155 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family COG0438 transferase activity, transferring glycosyl groups COG0629 single-stranded DNA binding COG0144 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA COG0781 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons COG0084 hydrolase, TatD family' COG0343 queuine tRNA-ribosyltransferase activity COG0422 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction COG0352 thiamine-phosphate diphosphorylase activity COG2022 thiamine diphosphate biosynthetic process COG0460 homoserine dehydrogenase COG0083 homoserine kinase activity COG0498 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine COG0498 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine COG0498 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine COG0441 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) COG0312 modulator of DNA gyrase COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG1473 amidohydrolase COG2954 triphosphatase activity COG3670 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen COG2211 Major facilitator Superfamily COG1963 PFAM Acid phosphatase vanadium-dependent haloperoxidase related COG1044 Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG1702 phosphate starvation-inducible protein PhoH COG0425 Belongs to the sulfur carrier protein TusA family COG0607 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS COG1619 proteins homologs of microcin C7 resistance protein MccF COG5009 serine-type D-Ala-D-Ala carboxypeptidase activity COG0194 GDP metabolic process COG0420 3'-5' exonuclease activity COG0628 permease COG0628 permease COG0419 ATPase involved in DNA repair COG1672 PFAM Archaeal ATPase COG4243 Vitamin k epoxide reductase COG0038 chloride channel COG0474 ATPase, P-type transporting, HAD superfamily, subfamily IC COG3842 ATPase activity COG1959 2 iron, 2 sulfur cluster binding COG1959 2 iron, 2 sulfur cluster binding COG0217 transcriptional regulatory protein COG3705 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine COG0484 heat shock protein binding COG0395 ABC-type sugar transport system, permease component COG0395 ABC-type sugar transport system, permease component COG0004 ammonium transporteR COG0004 ammonium transporteR COG0022 dehydrogenase e1 component COG0508 dehydrogenase complex catalyzes the overall conversion of COG2127 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation COG1132 (ABC) transporter COG0780 Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) COG2335 COG2335, Secreted and surface protein containing fasciclin-like repeats COG4178 (ABC) transporter COG0367 asparagine synthase COG0860 N-Acetylmuramoyl-L-alanine amidase COG2247 cell wall binding repeat COG0384 phenazine biosynthesis protein PhzF COG0861 Integral membrane protein TerC family COG0446 pyridine nucleotide-disulphide oxidoreductase COG0168 Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA COG0457 Tetratricopeptide repeat COG0463 Glycosyl transferase, family 2 COG0457 Tetratricopeptide repeat COG0463 Glycosyl transferase, family 2 COG0457 Tetratricopeptide repeat COG0463 Glycosyl transferase, family 2 COG0811 peptide transport COG0763 Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG2170 ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity COG0438 transferase activity, transferring glycosyl groups COG0429 hydrolase of the alpha beta-hydrolase fold COG0812 UDP-N-acetylmuramate dehydrogenase activity COG2385 sporulation resulting in formation of a cellular spore COG2385 sporulation resulting in formation of a cellular spore COG2045 Belongs to the ComB family COG1198 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA COG0438 transferase activity, transferring glycosyl groups COG0707 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) COG0024 Methionine aminopeptidase COG4172 Belongs to the ABC transporter superfamily COG2177 Part of the ABC transporter FtsEX involved in COG2884 Cell division ATP-binding protein ftsE COG0787 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids COG0316 Belongs to the HesB IscA family COG1090 epimerase COG0176 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway COG1989 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue COG2205 protein histidine kinase activity COG2179 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668 COG1947 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol COG0533 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction COG1834 amidinotransferase COG1840 ABC-type Fe3 transport system, periplasmic component COG0845 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family COG0517 IMP dehydrogenase activity COG0617 tRNA 3'-terminal CCA addition COG0618 3'(2'),5'-bisphosphate nucleotidase activity COG1181 Belongs to the D-alanine--D-alanine ligase family COG4251 negative regulation of phosphorylation COG1132 (ABC) transporter COG0693 protein deglycase activity COG0123 including yeast histone deacetylase and acetoin utilization protein COG0643 Histidine kinase COG0784 Response regulator, receiver COG2198 Histidine kinase COG0643 Histidine kinase COG0784 Response regulator, receiver COG2198 Histidine kinase COG0840 transmembrane signaling receptor activity COG2203 Gaf domain COG0840 transmembrane signaling receptor activity COG2203 Gaf domain COG0784 Response regulator, receiver COG3659 wide pore channel activity COG3659 wide pore channel activity COG3659 wide pore channel activity COG3659 wide pore channel activity COG0320 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives COG1122 ATPase activity COG0574 Belongs to the PEP-utilizing enzyme family COG1080 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) COG0317 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance COG0706 membrane insertase activity COG0594 ribonuclease P activity COG1154 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) COG1716 ATPase activity COG5001 Diguanylate cyclase COG1716 ATPase activity COG5001 Diguanylate cyclase COG0451 ADP-glyceromanno-heptose 6-epimerase activity COG1089 Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose COG0501 Belongs to the peptidase M48B family COG0577 efflux transmembrane transporter activity COG1136 (ABC) transporter COG0845 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family COG2217 Heavy metal translocating P-type atpase COG1004 Belongs to the UDP-glucose GDP-mannose dehydrogenase family COG0044 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides COG0637 HAD-superfamily hydrolase subfamily IA, variant 3 COG0166 Belongs to the GPI family COG0251 oxidation-reduction process COG0404 The glycine cleavage system catalyzes the degradation of glycine COG1331 Highly conserved protein containing a thioredoxin domain COG1539 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin COG1175 transmembrane transport COG0505 Belongs to the CarA family COG1420 regulation of RNA biosynthetic process COG1409 Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes COG0697 spore germination COG0781 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons COG1666 GTP binding COG0747 negative chemotaxis COG3118 belongs to the thioredoxin family COG3118 belongs to the thioredoxin family COG0678 peroxiredoxin activity COG0695 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins COG1121 (ABC) transporter COG0717 Belongs to the dCTP deaminase family COG0321 lipoyl(octanoyl) transferase activity COG0061 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family COG2006 4fe-4S ferredoxin, iron-sulfur binding domain protein COG0784 Response regulator, receiver COG2205 protein histidine kinase activity COG5002 protein histidine kinase activity COG0784 Response regulator, receiver COG2205 protein histidine kinase activity COG5002 protein histidine kinase activity COG0784 Response regulator, receiver COG2205 protein histidine kinase activity COG5002 protein histidine kinase activity COG0225 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG0275 rRNA processing COG0602 queuosine metabolic process COG2205 protein histidine kinase activity COG0596 Alpha beta hydrolase COG0596 Alpha beta hydrolase COG0809 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) COG5002 protein histidine kinase activity COG1028 Short-chain dehydrogenase reductase Sdr COG0741 lytic transglycosylase activity COG0661 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis COG1197 Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site COG1063 alcohol dehydrogenase COG0472 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan COG0192 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme COG0212 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family COG1253 flavin adenine dinucleotide binding COG1162 GTPase activity COG1882 Formate acetyltransferase COG0042 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines COG1216 Glycosyl transferase, family 2 COG1216 Glycosyl transferase, family 2 COG1216 Glycosyl transferase, family 2 COG1442 glycosyl transferase family 8 COG1216 Glycosyl transferase, family 2 COG1442 glycosyl transferase family 8 COG0154 amidase activity COG1216 Glycosyl transferase, family 2 COG4968 Prepilin-type N-terminal cleavage methylation domain COG0726 polysaccharide deacetylase COG0325 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family COG1472 Belongs to the glycosyl hydrolase 3 family COG2046 Belongs to the sulfate adenylyltransferase family COG0745 RESPONSE REGULATOR receiver COG0182 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) COG2166 iron-sulfur cluster assembly COG0344 acyl-phosphate glycerol-3-phosphate acyltransferase activity COG0340 biotin-[acetyl-CoA-carboxylase] ligase activity COG1654 Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein COG1521 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis COG1236 Exonuclease of the beta-lactamase fold involved in RNA processing COG0339 signal peptide processing COG0739 heme binding COG0768 penicillin binding COG3957 D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase COG1615 UPF0182 protein COG0457 Tetratricopeptide repeat COG0677 UDP-N-acetyl-D-mannosamine dehydrogenase activity COG0297 glycogen (starch) synthase activity COG0438 transferase activity, transferring glycosyl groups COG0515 serine threonine protein kinase COG1357 PFAM Pentapeptide repeats (8 copies) COG0515 serine threonine protein kinase COG1357 PFAM Pentapeptide repeats (8 copies) COG0515 serine threonine protein kinase COG1357 PFAM Pentapeptide repeats (8 copies) COG0515 serine threonine protein kinase COG1357 PFAM Pentapeptide repeats (8 copies) COG0515 serine threonine protein kinase COG1357 PFAM Pentapeptide repeats (8 copies) COG1606 tRNA processing COG3631 Ketosteroid isomerase-related protein COG0558 Belongs to the CDP-alcohol phosphatidyltransferase class-I family COG0179 Fumarylacetoacetate (FAA) hydrolase COG2010 Cytochrome c COG1070 Carbohydrate kinase COG1649 PFAM Uncharacterised BCR, COG1649 COG1122 ATPase activity COG0508 dehydrogenase complex catalyzes the overall conversion of COG0517 IMP dehydrogenase activity COG1994 Peptidase M50 COG1028 Short-chain dehydrogenase reductase Sdr COG5322 oxidoreductase activity COG1633 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) COG0205 6-phosphofructokinase activity COG0842 Transport permease protein COG1131 (ABC) transporter COG1716 ATPase activity COG0842 Transport permease protein COG1131 (ABC) transporter COG1716 ATPase activity COG0842 Transport permease protein COG1131 (ABC) transporter COG1716 ATPase activity COG0368 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate COG0612 Peptidase, M16 COG0612 Peptidase, M16 COG0547 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) COG0784 Response regulator, receiver COG2205 protein histidine kinase activity COG0426 domain, Protein COG1853 conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family COG0577 efflux transmembrane transporter activity COG1136 (ABC) transporter COG2138 Cobalamin (vitamin B12) biosynthesis CbiX protein COG0121 glutamine amidotransferase COG1304 FMN binding COG0053 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family COG0793 Belongs to the peptidase S41A family COG2340 Cysteine-rich secretory protein family COG0310 cobalt ion transport COG1225 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1189 Ribosomal RNA methyltransferase RrmJ FtsJ COG0115 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family COG0057 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity COG0515 serine threonine protein kinase COG1716 ATPase activity COG1118 Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system COG0837 glucose binding COG1060 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate COG0114 fumarate hydratase activity COG0564 pseudouridine synthase activity COG1175 transmembrane transport COG0714 Associated with various cellular activities COG0714 Associated with various cellular activities COG0634 Belongs to the purine pyrimidine phosphoribosyltransferase family COG0722 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) COG1137 ATPase activity COG0012 GTP binding COG0438 transferase activity, transferring glycosyl groups COG0438 transferase activity, transferring glycosyl groups COG0438 transferase activity, transferring glycosyl groups COG0403 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG2226 methyltransferase COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family COG0845 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity COG4121 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 COG0858 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA COG0397 Uncharacterized ACR, YdiU/UPF0061 family COG4783 chaperone-mediated protein folding COG0491 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid COG0177 DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate COG0750 zinc metalloprotease COG5002 protein histidine kinase activity COG0247 lactate metabolic process COG0815 Transfers the fatty acyl group on membrane lipoproteins COG0664 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein COG1842 Phage shock protein A COG1842 Phage shock protein A COG0623 enoyl-[acyl-carrier-protein] reductase (NADH) activity COG2326 polyphosphate kinase activity COG1178 ABC-type Fe3 transport system permease component COG2226 methyltransferase COG0792 nuclease activity COG3977 Valine--pyruvate aminotransferase COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate COG0860 N-Acetylmuramoyl-L-alanine amidase COG1055 Involved in arsenical resistance. Thought to form the channel of an arsenite pump COG4372 Transposase COG0496 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates COG0127 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions COG1135 Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system COG2843 Capsule synthesis protein COG0517 IMP dehydrogenase activity COG0794 Belongs to the SIS family. GutQ KpsF subfamily COG0616 signal peptide processing COG1166 arginine decarboxylase activity COG0003 Pfam Anion-transporting ATPase COG1035 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus COG3906 Belongs to the UPF0473 family COG0021 Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate COG0304 beta-ketoacyl-acyl-carrier-protein synthase II activity COG0789 Transcriptional regulator COG4221 oxidoreductase activity COG1612 heme a metabolic process COG0497 DNA recombination COG3128 pkhd-type hydroxylase COG5002 protein histidine kinase activity COG5002 protein histidine kinase activity COG2217 Heavy metal translocating P-type atpase COG0730 response to heat COG0492 ferredoxin-NADP+ reductase activity COG0691 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene COG0161 adenosylmethionine-8-amino-7-oxononanoate transaminase activity COG0195 Participates in both transcription termination and antitermination COG0779 Required for maturation of 30S ribosomal subunits COG0057 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity COG1573 uracil-dna glycosylase COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family COG0525 valine-tRNA ligase activity COG2308 Evidence 4 Homologs of previously reported genes of COG1543 Belongs to the glycosyl hydrolase 57 family COG0614 abc-type fe3 -hydroxamate transport system, periplasmic component COG0220 tRNA (guanine-N7-)-methyltransferase activity COG0598 Magnesium transport protein CorA COG0170 dolichyl monophosphate biosynthetic process COG0381 UDP-N-acetylglucosamine 2-epimerase activity COG0115 Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family COG3158 transport of potassium into the cell COG0436 Aminotransferase COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity COG3932 Exopolysaccharide synthesis, ExoD COG0058 SHG alpha-glucan phosphorylase activity COG0058 SHG alpha-glucan phosphorylase activity COG1820 Belongs to the metallo-dependent hydrolases superfamily. NagA family COG0436 Aminotransferase COG0240 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity COG0411 ABC transporter COG0411 ABC transporter COG0565 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA COG1725 Transcriptional regulator COG3937 granule-associated protein COG2094 Belongs to the DNA glycosylase MPG family COG0682 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins COG1028 Short-chain dehydrogenase reductase Sdr COG0382 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate COG0546 phosphoglycolate phosphatase activity COG0516 GMP reductase activity COG1185 polyribonucleotide nucleotidyltransferase activity COG0778 Nitroreductase COG4108 Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP COG0443 Heat shock 70 kDa protein COG0515 serine threonine protein kinase COG2815 serine threonine protein kinase COG1043 involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG0610 Subunit R is required for both nuclease and ATPase activities, but not for modification COG0610 Subunit R is required for both nuclease and ATPase activities, but not for modification COG0006 proline dipeptidase activity COG0079 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily COG0776 regulation of translation COG0469 pyruvate kinase activity COG0661 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis COG5505 Protein of unknown function (DUF819) COG1641 Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes COG2038 nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity COG1496 oxidoreductase activity COG4783 chaperone-mediated protein folding COG2065 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant COG0520 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine COG0816 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA COG0728 peptidoglycan biosynthetic process COG0536 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0745 RESPONSE REGULATOR receiver COG0611 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 COG0589 response to stress COG2226 methyltransferase COG1108 ABC-type Mn2 Zn2 transport systems permease components COG3385 transposase activity COG3385 transposase activity COG0499 May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine COG0062 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration COG0063 ADP-dependent NAD(P)H-hydrate dehydratase activity COG2377 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling COG0639 Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP COG0820 rRNA (adenine-C2-)-methyltransferase activity COG1122 ATPase activity COG1930 Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import COG0310 cobalt ion transport COG1473 amidohydrolase COG2173 Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide COG0452 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine COG0475 glutathione-regulated potassium exporter activity COG0589 response to stress COG2205 protein histidine kinase activity COG3344 reverse transcriptase COG3344 reverse transcriptase COG3344 reverse transcriptase COG3344 reverse transcriptase COG3344 reverse transcriptase COG3344 reverse transcriptase COG0204 Acyl-transferase COG0318 PFAM AMP-dependent synthetase and ligase COG0848 biopolymer transport protein COG1159 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG0563 adenylate kinase activity COG0101 tRNA pseudouridine synthase activity COG2957 Belongs to the agmatine deiminase family COG0484 heat shock protein binding COG0652 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides COG2814 Major facilitator Superfamily COG0009 L-threonylcarbamoyladenylate synthase COG0696 Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate COG1132 (ABC) transporter COG3411 Ferredoxin COG0735 belongs to the Fur family COG2205 protein histidine kinase activity COG0132 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring COG0625 glutathione transferase activity COG1012 belongs to the aldehyde dehydrogenase family COG1180 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine COG1012 belongs to the aldehyde dehydrogenase family COG1454 alcohol dehydrogenase COG0095 Lipoate-protein ligase COG0293 Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit COG0438 transferase activity, transferring glycosyl groups COG0367 asparagine synthase COG0745 RESPONSE REGULATOR receiver COG2268 Band 7 protein COG0105 UTP biosynthetic process COG0079 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily COG0619 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates COG0481 GTPase activity COG0637 HAD-superfamily hydrolase subfamily IA, variant 3 COG4577 Carbon dioxide concentrating mechanism carboxysome shell protein COG0484 heat shock protein binding COG2264 protein methyltransferase activity COG0797 Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides COG0840 transmembrane signaling receptor activity COG4581 dead DEAH box helicase COG0312 modulator of DNA gyrase COG1232 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX COG2119 membrane COG1207 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain COG0681 Belongs to the peptidase S26 family COG0161 adenosylmethionine-8-amino-7-oxononanoate transaminase activity COG0569 domain protein COG0431 NADPH-dependent FMN reductase COG1939 Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) COG1208 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon COG1208 COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon COG5002 protein histidine kinase activity COG0515 serine threonine protein kinase COG0475 glutathione-regulated potassium exporter activity COG1206 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs COG0796 Provides the (R)-glutamate required for cell wall biosynthesis COG0061 Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP COG2206 PFAM metal-dependent phosphohydrolase, HD sub domain COG0664 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein COG1108 ABC-type Mn2 Zn2 transport systems permease components COG0544 peptidyl-prolyl cis-trans isomerase activity COG0469 pyruvate kinase activity COG0445 tRNA wobble uridine modification COG2172 sigma factor antagonist activity COG0362 Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH COG1132 (ABC) transporter COG1600 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) COG0745 RESPONSE REGULATOR receiver COG0689 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates COG2066 Belongs to the glutaminase family COG1211 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity COG0701 Predicted permease COG0320 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives COG2148 undecaprenyl-phosphate glucose phosphotransferase activity COG0612 Peptidase, M16 COG0324 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) COG0557 exoribonuclease II activity COG1132 (ABC) transporter COG1187 pseudouridine synthase activity COG0148 phosphopyruvate hydratase activity COG0030 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG0388 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source COG1192 Involved in chromosome partitioning COG1049 propionate catabolic process, 2-methylcitrate cycle COG3046 protein related to deoxyribodipyrimidine photolyase COG3046 protein related to deoxyribodipyrimidine photolyase COG3046 protein related to deoxyribodipyrimidine photolyase COG1446 asparaginase COG1640 4-alpha-glucanotransferase COG1052 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family COG0617 tRNA 3'-terminal CCA addition COG0718 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection COG0668 transmembrane transport COG1968 undecaprenyl-diphosphatase activity COG0484 heat shock protein binding COG0574 Belongs to the PEP-utilizing enzyme family COG1080 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) COG1903 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A COG2223 nitrite transmembrane transporter activity COG0637 HAD-superfamily hydrolase subfamily IA, variant 3 COG3956 TIGRFAM MazG family protein COG2217 Heavy metal translocating P-type atpase COG1899 peptidyl-lysine modification to peptidyl-hypusine COG0652 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides COG0486 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 COG3096 Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division COG3264 Mechanosensitive ion channel COG3096 Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division COG3264 Mechanosensitive ion channel COG0663 COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily COG0119 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) COG1160 GTP binding COG1116 anion transmembrane transporter activity COG0237 dephospho-CoA kinase activity COG2203 Gaf domain COG3706 GGDEF domain COG4251 negative regulation of phosphorylation COG5001 Diguanylate cyclase COG1218 3'(2'),5'-bisphosphate nucleotidase COG1218 3'(2'),5'-bisphosphate nucleotidase COG0436 Aminotransferase COG2265 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family COG0805 protein transport COG1132 (ABC) transporter COG1192 Involved in chromosome partitioning COG2821 murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division COG4245 von Willebrand factor, type A COG2048 Heterodisulfide reductase, subunit B COG0821 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate COG0537 adenosine 5'-monophosphoramidase activity COG0486 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 COG0640 Transcriptional regulator COG0743 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity COG0761 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis COG1073 alpha beta COG2226 methyltransferase COG0438 transferase activity, transferring glycosyl groups COG0742 ribosomal rna small subunit methyltransferase COG0667 Aldo Keto reductase COG2099 Precorrin-6x reductase COG0806 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain COG4301 Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine COG0363 glucosamine-6-phosphate deaminase activity COG0274 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate COG0426 domain, Protein COG1853 conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family COG0620 Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation COG0559 Belongs to the binding-protein-dependent transport system permease family COG0559 Belongs to the binding-protein-dependent transport system permease family COG0559 Belongs to the binding-protein-dependent transport system permease family COG2812 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity COG0668 transmembrane transport COG2081 HI0933 family COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components COG0745 RESPONSE REGULATOR receiver COG0596 Alpha beta hydrolase COG3706 GGDEF domain COG0841 Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family COG0669 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate COG1071 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor COG2103 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate COG1441 menaquinone biosynthetic process COG1057 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) COG0171 NAD+ synthase (glutamine-hydrolyzing) activity COG0388 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source COG1225 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG0601 transmembrane transport COG1225 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG3706 GGDEF domain COG0229 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine COG0595 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay COG0799 negative regulation of ribosome biogenesis COG0474 ATPase, P-type transporting, HAD superfamily, subfamily IC COG0588 phosphoglycerate mutase activity COG1816 Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism COG0066 3-isopropylmalate dehydratase activity COG0601 transmembrane transport COG2062 phosphohistidine phosphatase, SixA COG0005 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate COG0448 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans COG1160 GTP binding COG0424 maF-like protein COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG0745 RESPONSE REGULATOR receiver COG0399 UDP-4-amino-4-deoxy-L-arabinose aminotransferase COG0451 ADP-glyceromanno-heptose 6-epimerase activity COG0542 response to heat COG0526 COG0526, thiol-disulfide isomerase and thioredoxins COG0412 Dienelactone hydrolase COG3063 Type IV pilus biogenesis stability protein PilW COG0272 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA COG0758 DNA mediated transformation COG1063 alcohol dehydrogenase COG0515 serine threonine protein kinase COG3266 domain, Protein COG1131 (ABC) transporter COG1672 PFAM Archaeal ATPase COG2319 Wd-40 repeat COG1028 Short-chain dehydrogenase reductase Sdr COG0313 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA COG2211 Major facilitator Superfamily COG0589 response to stress COG0589 response to stress COG0406 alpha-ribazole phosphatase activity COG0462 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG1366 Belongs to the anti-sigma-factor antagonist family COG0762 integral membrane protein COG0772 Belongs to the SEDS family COG0319 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA COG0818 Recycling of diacylglycerol produced during the turnover of membrane phospholipid COG1060 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate COG0130 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs COG0336 Belongs to the RNA methyltransferase TrmD family COG5001 Diguanylate cyclase COG0553 Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair COG0607 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS COG1018 Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress COG0483 inositol monophosphate 1-phosphatase activity COG0661 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis COG0242 peptide deformylase activity COG0509 glycine decarboxylation via glycine cleavage system COG1192 Involved in chromosome partitioning COG1489 DNA binding COG0014 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate COG1633 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) COG0603 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) COG1528 Iron-storage protein COG0845 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family COG0260 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides COG1385 rRNA (uridine-N3-)-methyltransferase activity COG0479 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family COG3842 ATPase activity COG1316 TRANSCRIPTIONal COG0020 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids COG0035 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate COG1136 (ABC) transporter COG0615 ADP-L-glycero-beta-D-manno-heptose biosynthetic process COG2870 Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose COG0774 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity COG0764 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity COG1043 involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell COG0219 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide COG1215 transferase activity, transferring glycosyl groups COG4636 protein conserved in cyanobacteria COG0394 Belongs to the low molecular weight phosphotyrosine protein phosphatase family COG3001 Fructosamine kinase COG0681 Belongs to the peptidase S26 family COG0461 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) COG0527 aspartate kinase activity COG0697 spore germination COG0739 heme binding COG1215 transferase activity, transferring glycosyl groups COG0226 Part of the ABC transporter complex PstSACB involved in phosphate import COG1327 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes COG1982 Orn Lys Arg decarboxylase major COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG1126 abc transporter atp-binding protein COG1131 (ABC) transporter COG3693 PFAM glycoside hydrolase, family 10 COG0396 ATPase activity COG0719 Fe-S assembly protein COG1196 nuclear chromosome segregation COG0800 Aldolase COG2227 3-demethylubiquinone-9 3-O-methyltransferase activity COG0354 folic acid binding COG0391 Required for morphogenesis under gluconeogenic growth conditions COG2226 methyltransferase COG0739 heme binding COG0033 Phosphoglucomutase COG0420 3'-5' exonuclease activity COG1234 tRNA 3'-trailer cleavage COG2205 protein histidine kinase activity COG1126 abc transporter atp-binding protein COG4100 CystaTHIonine beta-lyase family protein involved in aluminum resistance COG0857 belongs to the CobB CobQ family COG0556 nucleotide-excision repair COG0245 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity COG0583 DNA-binding transcription factor activity COG1970 mechanosensitive ion channel activity COG0125 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis COG0803 Belongs to the bacterial solute-binding protein 9 family COG3443 Belongs to the bacterial solute-binding protein 9 family COG1121 (ABC) transporter COG0275 rRNA processing COG0077 Prephenate dehydratase COG0686 Belongs to the AlaDH PNT family COG0483 inositol monophosphate 1-phosphatase activity COG0472 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan COG1058 Belongs to the CinA family COG1546 Belongs to the CinA family COG0241 D,D-heptose 1,7-bisphosphate phosphatase COG0659 secondary active sulfate transmembrane transporter activity COG0739 heme binding COG2302 S4 RNA-binding domain COG0226 Part of the ABC transporter complex PstSACB involved in phosphate import COG0573 inorganic phosphate transmembrane transporter activity COG0573 inorganic phosphate transmembrane transporter activity COG1117 ATPase-coupled phosphate ion transmembrane transporter activity COG0189 ligase activity COG0769 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan COG0419 ATPase involved in DNA repair COG2304 oxidoreductase activity COG0330 HflC and HflK could COG2095 MarC family integral membrane protein COG0741 lytic transglycosylase activity COG0791 NLP P60 protein COG0745 RESPONSE REGULATOR receiver COG0745 RESPONSE REGULATOR receiver COG1087 Belongs to the NAD(P)-dependent epimerase dehydratase family COG3781 membrane COG2217 Heavy metal translocating P-type atpase COG0043 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity COG1381 Involved in DNA repair and RecF pathway recombination COG2208 phosphoserine phosphatase activity COG0249 that it carries out the mismatch recognition step. This protein has a weak ATPase activity COG0661 Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis COG0631 protein serine/threonine phosphatase activity COG2109 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids COG0482 sulfurtransferase activity COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG3010 Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) COG0450 alkyl hydroperoxide reductase COG0523 cobalamin synthesis protein COG1217 gtp-binding protein TYPA COG4399 Belongs to the UPF0754 family COG0654 COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases COG2227 3-demethylubiquinone-9 3-O-methyltransferase activity COG4279 zinc finger COG2252 PERMEase COG0503 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis COG0282 Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction COG1316 TRANSCRIPTIONal COG1940 carbohydrate kinase activity COG0463 Glycosyl transferase, family 2 COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity COG2022 thiamine diphosphate biosynthetic process COG1836 PFAM Integral membrane protein DUF92 COG0372 Belongs to the citrate synthase family COG0064 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) COG4572 Cation transport regulator COG0489 protein tyrosine kinase activity COG0597 This protein specifically catalyzes the removal of signal peptides from prolipoproteins COG2205 protein histidine kinase activity COG0515 serine threonine protein kinase COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG3236 hydrolase activity, hydrolyzing N-glycosyl compounds COG0550 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone COG1754 DNA topoisomerase type I activity COG0149 triose-phosphate isomerase activity COG0450 alkyl hydroperoxide reductase COG0159 tryptophan synthase activity COG0133 tryptophan synthase activity COG0134 indole-3-glycerol-phosphate synthase activity COG0547 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) COG0147 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia COG0147 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia COG0135 phosphoribosylanthranilate isomerase activity COG0512 Glutamine amidotransferase of anthranilate synthase COG0547 Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) COG0180 Tryptophanyl-tRNA synthetase COG0526 COG0526, thiol-disulfide isomerase and thioredoxins COG3118 belongs to the thioredoxin family COG0264 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome COG2832 Protein of unknown function (DUF454) COG0271 Belongs to the BolA IbaG family COG0694 Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins COG1977 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin COG1826 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes COG0721 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) COG2154 pterin-4-alpha-carbinolamine dehydratase COG1600 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) COG1143 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0276 Catalyzes the ferrous insertion into protoporphyrin IX COG0724 RNA recognition motif COG2052 Domain of unknown function (DUF370) COG3536 Protein conserved in bacteria COG1366 Belongs to the anti-sigma-factor antagonist family COG0276 Catalyzes the ferrous insertion into protoporphyrin IX COG0759 Could be involved in insertion of integral membrane proteins into the membrane COG1376 ErfK ybiS ycfS ynhG family protein COG3288 NAD(P)+ transhydrogenase (AB-specific) activity COG0695 Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins COG1977 Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin COG1117 ATPase-coupled phosphate ion transmembrane transporter activity COG0765 amino acid transport COG2127 Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation COG0724 RNA recognition motif COG0276 Catalyzes the ferrous insertion into protoporphyrin IX COG1872 DUF167 COG1828 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL COG0050 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis COG0287 Prephenate dehydrogenase COG0162 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) COG0382 Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate COG0163 prenyltransferase activity COG0831 urea catabolic process COG0832 Belongs to the urease beta subunit family COG0804 urea catabolic process COG0829 nickel cation binding COG2371 Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly COG0830 nickel cation binding COG0378 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG COG0178 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate COG0322 excinuclease ABC activity COG0525 valine-tRNA ligase activity COG0719 Fe-S assembly protein COG0745 RESPONSE REGULATOR receiver COG0457 Tetratricopeptide repeat COG0583 DNA-binding transcription factor activity COG0702 epimerase COG0629 single-stranded DNA binding COG3854 ATPases associated with a variety of cellular activities COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG4447 cellulose binding COG1799 cell septum assembly COG1799 cell septum assembly COG0454 -acetyltransferase COG0515 serine threonine protein kinase COG2197 response regulator COG1234 tRNA 3'-trailer cleavage COG1555 photosystem II stabilization COG0316 Belongs to the HesB IscA family COG1633 Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) COG0037 tRNA processing COG0767 ABC-type transport system involved in resistance to organic solvents, permease component COG0278 Belongs to the glutaredoxin family. Monothiol subfamily COG0515 serine threonine protein kinase COG4956 integral membrane protein (PIN domain superfamily) COG0824 Thioesterase COG0557 exoribonuclease II activity COG0364 Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone