locus-tag	class	description
NIES2134_100050	ENOG4105CQM	Urea amidohydrolase subunit alpha
NIES2134_100070	ENOG4107QZ7	Cellulose synthase catalytic subunit
NIES2134_100140	ENOG41080ZE	Adenylate cyclase
NIES2134_100170	ENOG4105X1F	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity)
NIES2134_100210	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
NIES2134_100290	ENOG4105BZU	Histidine kinase
NIES2134_100310	ENOG4105EKQ	RNA-directed DNA polymerase
NIES2134_100330	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
NIES2134_100370	ENOG4107TVC	Glycosyl transferase, family 2
NIES2134_100400	ENOG4105EMN	RNA polymerase sigma factor
NIES2134_100450	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
NIES2134_100460	ENOG4106PVI	ATP-dependent carboxylate-amine ligase (By similarity)
NIES2134_100480	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
NIES2134_100500	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
NIES2134_100510	ENOG4105CPK	Glycosyl transferase (Group 1
NIES2134_100540	ENOG4105KI2	Urea amidohydrolase subunit beta
NIES2134_100550	ENOG4108S7T	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)
NIES2134_100580	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
NIES2134_100610	ENOG4105CVN	desaturase
NIES2134_100630	ENOG4107QHM	Sulfite reductase
NIES2134_100680	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
NIES2134_100700	ENOG4108UNF	response regulator
NIES2134_100710	ENOG4105M3Z	response regulator
NIES2134_100730	ENOG4105C8Q	Methyl-accepting chemotaxis
NIES2134_100740	ENOG4105CBS	Chea signal transduction histidine kinase
NIES2134_100750	ENOG4105CQR	helicase
NIES2134_100770	ENOG4105FIK	Inherit from COG: dihydropteroate synthase
NIES2134_100820	ENOG4108S64	thioredoxin-like protein txlA
NIES2134_100860	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
NIES2134_100940	ENOG4105CIH	Imidazole acetol-phosphate transaminase
NIES2134_100960	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
NIES2134_101000	ENOG4107Z6A	sulfate abc transporter permease
NIES2134_101010	ENOG4105DE7	Sulfate ABC transporter periplasmic sulfate-binding protein
NIES2134_101030	ENOG4105CTK	cobaltochelatase, cobn subunit
NIES2134_101040	ENOG4108JJB	ABC transporter
NIES2134_101060	ENOG4107TS3	membrane protein, TerC
NIES2134_101070	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
NIES2134_101080	ENOG4107TIF	Phenazine biosynthesis protein, PhzF family
NIES2134_101090	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
NIES2134_101100	ENOG4105WVZ	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
NIES2134_101140	ENOG4105CAT	Cytidine monophosphate kinase
NIES2134_101200	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
NIES2134_101220	ENOG41080W8	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
NIES2134_101230	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
NIES2134_101240	ENOG4105W4R	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
NIES2134_101260	ENOG4108JJB	ABC transporter
NIES2134_101270	ENOG4105M3Z	response regulator
NIES2134_101300	ENOG4105EVN	Prephenate dehydrogenase
NIES2134_101370	ENOG4108USA	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity)
NIES2134_101390	ENOG4105C6E	dna polymerase iii
NIES2134_101410	ENOG4108R9R	May be involved in photosynthetic membrane biogenesis (By similarity)
NIES2134_101440	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
NIES2134_101500	ENOG4105C9M	aspartyl-trna synthetase
NIES2134_101520	ENOG4105D8X	mechanosensitive ion channel
NIES2134_101530	ENOG4105CBX	hi0933 family
NIES2134_101550	ENOG4107ZH9	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
NIES2134_101570	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
NIES2134_101580	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
NIES2134_101630	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
NIES2134_101640	ENOG4105BZU	Histidine kinase
NIES2134_101650	ENOG4105BZS	acriflavin resistance protein
NIES2134_101670	ENOG4105Q36	FHA domain containing protein
NIES2134_101720	ENOG4107QMH	DNA methylase
NIES2134_101790	ENOG4105EY5	This is one of the two reaction center proteins of photosystem II
NIES2134_101830	ENOG4105DA5	(ABC) transporter
NIES2134_101850	ENOG4105DDQ	anthranilate synthase
NIES2134_101900	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
NIES2134_101960	ENOG4107WDG	serine threonine protein kinase
NIES2134_102000	ENOG4105DX0	Hemolysin A
NIES2134_102060	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_102080	ENOG4105DVK	Precorrin-2 c20-methyltransferase
NIES2134_102140	ENOG4105VFU	Rna-binding protein
NIES2134_102170	ENOG4105EHV	domain protein
NIES2134_102210	ENOG4105K63	Thioredoxin
NIES2134_102230	ENOG4107QRA	Extracellular solute-binding protein, family 5
NIES2134_102240	ENOG4105DXN	mazG family
NIES2134_102250	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
NIES2134_102290	ENOG4105VUV	UPF0367 protein
NIES2134_102300	ENOG4107S75	HAD-superfamily hydrolase subfamily IA variant 3
NIES2134_102390	ENOG4108VPT	UPF0234 protein
NIES2134_102410	ENOG4105CFG	Acts as a chaperone (By similarity)
NIES2134_102420	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
NIES2134_102450	ENOG4107Y1F	Involved in the transcription termination process (By similarity)
NIES2134_102480	ENOG4105D49	3-dehydroquinate synthase
NIES2134_102490	ENOG4105EYM	Major Facilitator superfamily
NIES2134_102520	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
NIES2134_102550	ENOG4107QP0	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
NIES2134_102580	ENOG41070EG	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)
NIES2134_102610	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
NIES2134_102620	ENOG4107VQD	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
NIES2134_102650	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
NIES2134_102660	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
NIES2134_102680	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
NIES2134_102690	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
NIES2134_102710	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
NIES2134_102770	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
NIES2134_102790	ENOG4108MV2	Involved in light-induced Na( )-dependent proton extrusion. Also seems to be involved in CO(2) transport (By similarity)
NIES2134_102870	ENOG4107QSS	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli (By similarity)
NIES2134_102880	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
NIES2134_102930	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
NIES2134_102960	ENOG4108ZGN	Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity)
NIES2134_102970	ENOG4105EHU	Circadian clock protein KaiC
NIES2134_102980	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
NIES2134_102990	ENOG4108ESY	Metal dependent phosphohydrolase
NIES2134_103020	ENOG4105WGP	Catalyzes the hydrolysis of 1,4-dihydroxy-2-naphthoyl- CoA (DHNA-CoA) to 1,4-dihydroxy-2-naphthoate (DHNA), a reaction involved in phylloquinone (vitamin K1) biosynthesis (By similarity)
NIES2134_103070	ENOG4105MSA	Photosystem II reaction center W protein
NIES2134_103090	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
NIES2134_103100	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
NIES2134_103120	ENOG4105IJJ	transcriptional regulator, crp fnr family
NIES2134_103150	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
NIES2134_103170	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
NIES2134_103210	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
NIES2134_103220	ENOG4105CIK	Amidinotransferase
NIES2134_103230	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
NIES2134_103240	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
NIES2134_103250	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
NIES2134_103300	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
NIES2134_103350	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
NIES2134_103370	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
NIES2134_103380	ENOG4105EEK	Polypeptide
NIES2134_103390	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
NIES2134_103450	ENOG4105K64	Glycosyl transferase, family 2
NIES2134_103480	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
NIES2134_103500	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
NIES2134_103530	ENOG41072GX	Peptidase M22 Glycoprotease
NIES2134_103550	ENOG4107VRP	DNA repair exonuclease
NIES2134_103570	ENOG4105C0H	protease
NIES2134_103580	ENOG4105E8T	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)
NIES2134_103610	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
NIES2134_103620	ENOG4108IV0	ABC, transporter
NIES2134_103650	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
NIES2134_103660	ENOG4108JQC	penicillin-binding protein 1A
NIES2134_103710	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
NIES2134_103720	ENOG4105VFE	sira family
NIES2134_103730	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
NIES2134_103740	ENOG4105CEY	Amp-dependent synthetase and ligase
NIES2134_103760	ENOG41082B1	30S ribosomal protein S16
NIES2134_103780	ENOG4105VCC	30S ribosomal protein S21
NIES2134_103840	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
NIES2134_103850	ENOG4105EKQ	RNA-directed DNA polymerase
NIES2134_103890	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
NIES2134_103910	ENOG4105CZN	Potassium uptake protein
NIES2134_103920	ENOG4108HMX	isocitrate dehydrogenase (NADP)
NIES2134_103940	ENOG4105KAN	Probably a ribosomal protein or a ribosome-associated protein (By similarity)
NIES2134_103960	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
NIES2134_103970	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
NIES2134_103980	ENOG4107Z3D	50S ribosomal protein l10
NIES2134_103990	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
NIES2134_104000	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
NIES2134_104070	ENOG4107SA8	fad-dependent pyridine nucleotide-disulfide oxidoreductase
NIES2134_104110	ENOG4107U45	Cobalt transport protein
NIES2134_104140	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
NIES2134_104150	ENOG4105EWN	Heme oxygenase
NIES2134_104160	ENOG4105CH7	arginosuccinase
NIES2134_104190	ENOG4107TVC	Glycosyl transferase, family 2
NIES2134_104200	ENOG4105D4A	Cell wall formation (By similarity)
NIES2134_104210	ENOG4105DFU	Cell wall formation (By similarity)
NIES2134_104240	ENOG4105C1Q	protoporphyrinogen oxidase
NIES2134_104330	ENOG4105JFG	SpoIID LytB domain protein
NIES2134_104350	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
NIES2134_104370	ENOG4105D7V	transposase
NIES2134_104380	ENOG4108RS6	transposase
NIES2134_104390	ENOG4105WMR	Protein CrcB homolog
NIES2134_104400	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
NIES2134_104420	ENOG4105NZG	Ferredoxin
NIES2134_104440	ENOG4108IJ9	(ABC) transporter
NIES2134_104480	ENOG4105K46	50S ribosomal protein l27
NIES2134_104490	ENOG41082FX	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
NIES2134_104540	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
NIES2134_104570	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
NIES2134_104580	ENOG4105CDY	transcriptional regulatory protein
NIES2134_104590	ENOG4106815	This protein is a component of the reaction center of photosystem II (By similarity)
NIES2134_104600	ENOG4108Z6B	deaminase
NIES2134_104630	ENOG4107WMZ	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
NIES2134_104640	ENOG410811H	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
NIES2134_104650	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
NIES2134_104680	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
NIES2134_104690	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
NIES2134_104700	ENOG4105DRS	transport system, permease
NIES2134_104730	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
NIES2134_104750	ENOG4105I3K	Ferric uptake regulator, Fur family
NIES2134_104780	ENOG41062D9	Histidine kinase
NIES2134_104850	ENOG4108JIS	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
NIES2134_104890	ENOG4108062	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
NIES2134_104900	ENOG4108TGY	Glutathione S-transferase
NIES2134_104940	ENOG4105J3Z	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
NIES2134_104950	ENOG4105CRK	lysyL-tRNA synthetase
NIES2134_104960	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
NIES2134_104970	ENOG4105BZ1	(ABC) transporter
NIES2134_104980	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
NIES2134_105000	ENOG4107Z8Z	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
NIES2134_105020	ENOG410906A	Beta-Ig-H3 fasciclin
NIES2134_105060	ENOG4105F1A	Pyruvate formate-lyase
NIES2134_105070	ENOG4108EKI	Dehydrogenase
NIES2134_105080	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
NIES2134_105110	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
NIES2134_105120	ENOG4105EWK	phytoene
NIES2134_105130	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
NIES2134_105230	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
NIES2134_105240	ENOG4107XU6	Glycosyl transferase (Group 1
NIES2134_105360	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
NIES2134_105410	ENOG4108RS6	transposase
NIES2134_105420	ENOG4105D7V	transposase
NIES2134_105450	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
NIES2134_105460	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
NIES2134_105480	ENOG4107Y2H	ErfK ybiS ycfS ynhG family protein
NIES2134_105500	ENOG4105DBS	Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)
NIES2134_105510	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
NIES2134_105670	ENOG41082X4	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
NIES2134_105690	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
NIES2134_105700	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
NIES2134_105710	ENOG4105CD3	dihydroorotase
NIES2134_105720	ENOG4108IAJ	Nad-dependent epimerase dehydratase
NIES2134_105730	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
NIES2134_105740	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
NIES2134_105750	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
NIES2134_105760	ENOG4107QSQ	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
NIES2134_105780	ENOG4105D7V	transposase
NIES2134_105790	ENOG4108RS6	transposase
NIES2134_105810	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
NIES2134_105820	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
NIES2134_105830	ENOG4105C59	p-type ATPase
NIES2134_105860	ENOG4105BZ1	(ABC) transporter
NIES2134_105930	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
NIES2134_105950	ENOG4108R99	pseudouridine synthase
NIES2134_105980	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
NIES2134_105990	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
NIES2134_106000	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
NIES2134_106010	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
NIES2134_106020	ENOG4105D0M	Protease HtpX homolog
NIES2134_106080	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
NIES2134_106130	ENOG4105C1V	Peptidase, M16
NIES2134_106170	ENOG4105D3Q	Sugar transferase
NIES2134_106200	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
NIES2134_106260	ENOG4105D7V	transposase
NIES2134_106270	ENOG4108RS6	transposase
NIES2134_106290	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
NIES2134_106330	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
NIES2134_106340	ENOG4105DBV	ornithine carbamoyltransferase
NIES2134_106380	ENOG4108V1T	peptidylprolyl cis-trans isomerase
NIES2134_106510	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
NIES2134_106530	ENOG4105CNW	domain protein
NIES2134_106540	ENOG410902K	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)
NIES2134_106610	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
NIES2134_106690	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
NIES2134_106700	ENOG41067HS	methyltransferase
NIES2134_106710	ENOG4105E5Q	amino acid AbC transporter
NIES2134_106730	ENOG4106PMH	Extracellular solute-binding protein family 3
NIES2134_106740	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
NIES2134_106750	ENOG41080P6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
NIES2134_106800	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
NIES2134_106840	ENOG4105C01	Dihydroxy-acid dehydratase
NIES2134_106870	ENOG4108FN7	Aldo keto reductase
NIES2134_106880	ENOG4106H78	methyltransferase
NIES2134_106920	ENOG41065W4	chlorophyll a b binding light harvesting protein
NIES2134_106940	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
NIES2134_106950	ENOG4107STW	synthase
NIES2134_106970	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
NIES2134_106980	ENOG4107RIQ	Sulfate adenylate transferase
NIES2134_107000	ENOG4105D17	glycoside hydrolase, family 3 domain protein
NIES2134_107020	ENOG4107RAJ	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
NIES2134_107030	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
NIES2134_107140	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
NIES2134_107150	ENOG4107QIB	glycyl-tRNA synthetase, alpha subunit
NIES2134_107160	ENOG4108ZJ4	polysaccharide deacetylase
NIES2134_107260	ENOG4107TVC	Glycosyl transferase, family 2
NIES2134_107270	ENOG4105BZU	Histidine kinase
NIES2134_107280	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
NIES2134_107300	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
NIES2134_107320	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
NIES2134_107330	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
NIES2134_107350	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
NIES2134_107370	ENOG4105J0C	
NIES2134_107380	ENOG4105CDU	Replicative dna helicase
NIES2134_107380	ENOG4105CDU	Replicative dna helicase
NIES2134_107420	ENOG4105F8J	Adenylate Guanylate cyclase
NIES2134_107430	ENOG41060KK	Stabilizes the structure of photosystem II oxygen- evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation (By similarity)
NIES2134_107440	ENOG4108IYU	L-aspartate oxidase
NIES2134_107480	ENOG4108SIY	photosystem I reaction center protein subunit XI
NIES2134_107530	ENOG4105D7V	transposase
NIES2134_107540	ENOG4108RS6	transposase
NIES2134_107560	ENOG4105ED7	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)
NIES2134_107570	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
NIES2134_107580	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
NIES2134_107600	ENOG4105EVY	Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity)
NIES2134_107620	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
NIES2134_107640	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
NIES2134_107720	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
NIES2134_107780	ENOG4105D7V	transposase
NIES2134_107790	ENOG4107QKW	extracellular solute-binding protein family 1
NIES2134_107850	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
NIES2134_107860	ENOG4105FA2	dna polymerase iii
NIES2134_107870	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
NIES2134_107900	ENOG4105CPF	Cell wall formation (By similarity)
NIES2134_107920	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
NIES2134_107930	ENOG410823V	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
NIES2134_107970	ENOG41085RW	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
NIES2134_107980	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
NIES2134_108000	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
NIES2134_108030	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
NIES2134_108040	ENOG4108M9X	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
NIES2134_108070	ENOG4107RNI	Glucose 6-phosphate dehydrogenase effector OpcA
NIES2134_108090	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NIES2134_108160	ENOG4108ZBE	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity)
NIES2134_108170	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
NIES2134_108180	ENOG4108ZGN	Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity)
NIES2134_108190	ENOG4105CZX	twitching motility protein
NIES2134_108220	ENOG4105BZ1	(ABC) transporter
NIES2134_108250	ENOG4107R7Y	intracellular protease Pfpi family
NIES2134_108260	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
NIES2134_108270	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
NIES2134_108310	ENOG4105CBS	Chea signal transduction histidine kinase
NIES2134_108330	ENOG4105M3Z	response regulator
NIES2134_108350	ENOG4108PWY	Carbohydrate-selective porin OprB
NIES2134_108360	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
NIES2134_108380	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
NIES2134_108390	ENOG4105BZ1	(ABC) transporter
NIES2134_108400	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
NIES2134_108410	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
NIES2134_108430	ENOG4108JJB	ABC transporter
NIES2134_108440	ENOG4105Q84	sucrose synthase
NIES2134_108450	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
NIES2134_108490	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
NIES2134_108510	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
NIES2134_108530	ENOG4105E2X	shikimate dehydrogenase
NIES2134_108550	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
NIES2134_108570	ENOG4105C0P	Mg chelatase subunit ChlI
NIES2134_108630	ENOG4107RIX	inner membrane protein translocase component YidC
NIES2134_108640	ENOG41082ZZ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
NIES2134_108660	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
NIES2134_108670	ENOG4105D7V	transposase
NIES2134_108680	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
NIES2134_108760	ENOG4108PJD	permease
NIES2134_108770	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
NIES2134_108780	ENOG4108NWW	ferritin dps family protein
NIES2134_108810	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
NIES2134_108830	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
NIES2134_108840	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
NIES2134_108860	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
NIES2134_108920	ENOG4108VAU	general secretion pathway protein G
NIES2134_108960	ENOG4105ECJ	Glycosyl Transferase
NIES2134_108990	ENOG4106855	Competence protein
NIES2134_109010	ENOG4105CBS	Chea signal transduction histidine kinase
NIES2134_109040	ENOG4105M3Z	response regulator
NIES2134_109050	ENOG4108UNF	response regulator
NIES2134_109060	ENOG4105C09	Bile acid
NIES2134_109080	ENOG4108IV0	ABC, transporter
NIES2134_109090	ENOG4105C0Z	ABC transporter
NIES2134_109100	ENOG4105C32	Amino acid ABC transporter (Permease)
NIES2134_109110	ENOG4105C32	Amino acid ABC transporter (Permease)
NIES2134_109120	ENOG4107TSX	ABC branched chain amino acid family transporter periplasmic ligand binding protein
NIES2134_109140	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
NIES2134_109180	ENOG4107S6X	Glycosyl transferase, family 2
NIES2134_109210	ENOG4105C6N	Formate acetyltransferase
NIES2134_109240	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
NIES2134_109300	ENOG4108YZ9	Urea amidohydrolase subunit gamma
NIES2134_109310	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
NIES2134_109320	ENOG41086B8	CoB-CoM heterodisulfide reductase
NIES2134_109330	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
NIES2134_109370	ENOG4108M24	von Willebrand factor, type A
NIES2134_109390	ENOG4108M24	von Willebrand factor, type A
NIES2134_109460	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
NIES2134_109470	ENOG4105CPQ	Dehydrogenase
NIES2134_109480	ENOG4105CA3	membrane-bound lytic murein transglycosylase
NIES2134_109510	ENOG4105CP7	Triose-phosphate isomerase
NIES2134_109530	ENOG4107WCQ	Anion-transporting ATPase
NIES2134_109540	ENOG4105BZ1	(ABC) transporter
NIES2134_109590	ENOG4108MAQ	allophycocyanin alpha
NIES2134_109600	ENOG4105FBM	allophycocyanin beta subunit
NIES2134_109610	ENOG4105W5K	Rod linker protein, associated with allophycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer (By similarity)
NIES2134_109620	ENOG4105KNY	Microcompartments protein
NIES2134_109650	ENOG4105D7V	transposase
NIES2134_109660	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
NIES2134_109700	ENOG4105KNY	Microcompartments protein
NIES2134_109710	ENOG4108WT6	Carbon dioxide concentrating mechanism protein
NIES2134_109720	ENOG4105WVM	ethanolamine utilization protein EutN carboxysome structural protein Ccml
NIES2134_109730	ENOG4105MXK	Carbon dioxide concentrating mechanism protein
NIES2134_109740	ENOG4105MN7	Carbon dioxide concentrating mechanism protein
NIES2134_109750	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
NIES2134_109800	ENOG4105DFF	Rod shape-determining protein mreb
NIES2134_109850	ENOG4107SC1	transglycosylase
NIES2134_109890	ENOG4105CHM	Aminotransferase
NIES2134_109910	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
NIES2134_109920	ENOG4108JQ6	ABC transporter
NIES2134_109930	ENOG4105EB3	Histidine kinase
NIES2134_109960	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
NIES2134_110000	ENOG4105D74	hydrolase
NIES2134_110030	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
NIES2134_110050	ENOG4105D7V	transposase
NIES2134_110060	ENOG4105EKQ	RNA-directed DNA polymerase
NIES2134_110070	ENOG4107QI6	Cysteine desulfurase
NIES2134_110090	ENOG4105BZU	Histidine kinase
NIES2134_110110	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
NIES2134_110120	ENOG4105D7Z	glutathione synthase
NIES2134_110150	ENOG4105C8S	subunit m
NIES2134_110160	ENOG4105D65	subunit l
NIES2134_110200	ENOG4105CTK	cobaltochelatase, cobn subunit
NIES2134_110210	ENOG4105BZU	Histidine kinase
NIES2134_110220	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
NIES2134_110250	ENOG4107WPW	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
NIES2134_110300	ENOG4108IY8	ABC, transporter
NIES2134_110330	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
NIES2134_110350	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
NIES2134_110380	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
NIES2134_110420	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
NIES2134_110430	ENOG4105BZU	Histidine kinase
NIES2134_110460	ENOG4105VN1	Heat shock protein
NIES2134_110580	ENOG4108R4Z	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)
NIES2134_110610	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
NIES2134_110620	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
NIES2134_110680	ENOG4105D7W	serine acetyltransferase
NIES2134_110740	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
NIES2134_110750	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
NIES2134_110760	ENOG4108Z0R	Transferase
NIES2134_110810	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
NIES2134_110870	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
NIES2134_110880	ENOG4105WVZ	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
NIES2134_110900	ENOG4105EGS	Mechanosensitive ion channel
NIES2134_110940	ENOG4105C75	arginyL-tRNA synthetase
NIES2134_110950	ENOG4105DHP	deoxycytidine triphosphate deaminase
NIES2134_110960	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
NIES2134_111010	ENOG4105DIK	(ABC) transporter
NIES2134_111020	ENOG4105E0R	Deoxyhypusine synthase
NIES2134_111040	ENOG4105C59	p-type ATPase
NIES2134_111050	ENOG4105EHV	domain protein
NIES2134_111060	ENOG4105D7V	transposase
NIES2134_111120	ENOG4105CPQ	Dehydrogenase
NIES2134_111150	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
NIES2134_111180	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NIES2134_111190	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
NIES2134_111200	ENOG4105D7K	pfkb domain protein
NIES2134_111220	ENOG4105FBB	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity)
NIES2134_111240	ENOG41067UF	
NIES2134_111300	ENOG4105CFT	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)
NIES2134_111350	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
NIES2134_111360	ENOG4105K4I	Scp-like extracellular
NIES2134_111390	ENOG4105CAS	nag kinase
NIES2134_111410	ENOG4105CN1	protease
NIES2134_111440	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
NIES2134_111500	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
NIES2134_111580	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
NIES2134_111590	ENOG4108S5W	Seems to be required for the assembly of the photosystem I complex (By similarity)
NIES2134_111600	ENOG410686T	photosystem II reaction center protein N
NIES2134_111610	ENOG4105WIA	photosystem II reaction center protein H
NIES2134_111620	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
NIES2134_111630	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
NIES2134_111640	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
NIES2134_111660	ENOG4105DRS	transport system, permease
NIES2134_111750	ENOG4105D7V	transposase
NIES2134_111760	ENOG4105CNW	domain protein
NIES2134_111820	ENOG4105BZU	Histidine kinase
NIES2134_111830	ENOG4105MMR	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)
NIES2134_111840	ENOG4108YH3	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)
NIES2134_111880	ENOG41067WU	Molybdopterin converting factor (Subunit 1)
NIES2134_111910	ENOG4108I0Q	anthranilate phosphoribosyltransferase
NIES2134_111950	ENOG4105D7T	ABC transporter
NIES2134_111990	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
NIES2134_112050	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
NIES2134_112100	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
NIES2134_112110	ENOG4105IDI	abc transporter atp-binding protein
NIES2134_112160	ENOG4107Z12	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
NIES2134_112220	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
NIES2134_112230	ENOG4108KXV	response regulator
NIES2134_112240	ENOG4105IDI	abc transporter atp-binding protein
NIES2134_112250	ENOG4105C8Y	Acetylornithine aminotransferase
NIES2134_112260	ENOG4107VC8	ATP cone domain protein
NIES2134_112340	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
NIES2134_112350	ENOG4105C0Z	ABC transporter
NIES2134_112360	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
NIES2134_112380	ENOG4107R1X	phosphohexokinase
NIES2134_112390	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
NIES2134_112400	ENOG4107Z9D	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NIES2134_112420	ENOG410612X	Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane
NIES2134_112440	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
NIES2134_112450	ENOG4105CHR	reductase
NIES2134_112460	ENOG4105EUJ	GTP cyclohydrolase i
NIES2134_112480	ENOG4105E4R	Precorrin-3B C17-methyltransferase
NIES2134_112530	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
NIES2134_112540	ENOG4108Z03	MAF-like protein
NIES2134_112590	ENOG4105F32	YngK protein
NIES2134_112600	ENOG4105C7K	acetolactate synthase
NIES2134_112610	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
NIES2134_112620	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
NIES2134_112630	ENOG41083MR	nifu domain-containing protein
NIES2134_112650	ENOG4107S5T	Carbohydrate kinase
NIES2134_112660	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
NIES2134_112690	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
NIES2134_112700	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
NIES2134_112720	ENOG4108UQX	Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II (By similarity)
NIES2134_112730	ENOG4108Z61	cytochrome c-550
NIES2134_112750	ENOG4105BZU	Histidine kinase
NIES2134_112760	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
NIES2134_112780	ENOG41082BG	Binds together with S18 to 16S ribosomal RNA (By similarity)
NIES2134_112790	ENOG4105ERH	Fumarylacetoacetate hydrolase
NIES2134_112810	ENOG4105CBT	Fructose-1,6-bisphosphatase
NIES2134_112820	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
NIES2134_112840	ENOG4105E66	phosphoriboisomerase A
NIES2134_112910	ENOG410902C	phosphohistidine phosphatase, SixA
NIES2134_112940	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
NIES2134_112990	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
NIES2134_113030	ENOG4108JYK	Dehydrogenase
NIES2134_113050	ENOG4105E15	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NIES2134_113080	ENOG4105D7V	transposase
NIES2134_113100	ENOG4105DNI	Converts SHCHC to OSB (By similarity)
NIES2134_113120	ENOG4105D7V	transposase
NIES2134_113170	ENOG4105DGW	oligopeptidase A
NIES2134_113180	ENOG4105DR5	peptidase
NIES2134_113190	ENOG4105CJN	penicillin-binding protein
NIES2134_113210	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
NIES2134_113220	ENOG4107QRI	Phosphoketolase
NIES2134_113250	ENOG41084H8	Binds directly to 16S ribosomal RNA (By similarity)
NIES2134_113260	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
NIES2134_113280	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
NIES2134_113300	ENOG4105DJZ	UPF0182 protein
NIES2134_113310	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_113320	ENOG4105EJG	cellulose synthase
NIES2134_113340	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
NIES2134_113350	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_113390	ENOG4107QQG	Dehydrogenase
NIES2134_113400	ENOG4107RA4	Glycosyl transferase (Group 1
NIES2134_113440	ENOG4105DUM	transcriptional regulator, lysR family
NIES2134_113450	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
NIES2134_113480	ENOG4105BZU	Histidine kinase
NIES2134_113490	ENOG4107SC0	ferredoxin--NADP reductase
NIES2134_113510	ENOG4105E4F	Isochorismate synthase
NIES2134_113520	ENOG4105E0X	reductase
NIES2134_113530	ENOG4105ES5	Histidine kinase
NIES2134_113540	ENOG41080W8	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
NIES2134_113570	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
NIES2134_113590	ENOG4105CEY	Amp-dependent synthetase and ligase
NIES2134_113610	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
NIES2134_113620	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
NIES2134_113660	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
NIES2134_113700	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
NIES2134_113730	ENOG4105EKD	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity)
NIES2134_113770	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
NIES2134_113790	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
NIES2134_113830	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
NIES2134_113840	ENOG4108PWY	Carbohydrate-selective porin OprB
NIES2134_113890	ENOG4107QRP	cobalamin biosynthesis protein CobW
NIES2134_113910	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
NIES2134_113940	ENOG4105IDI	abc transporter atp-binding protein
NIES2134_113970	ENOG4105CD5	CoA-binding domain protein
NIES2134_114020	ENOG4105D7V	transposase
NIES2134_114040	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
NIES2134_114050	ENOG4105DT1	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate
NIES2134_114080	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
NIES2134_114150	ENOG4107QPR	SAICAR synthetase
NIES2134_114160	ENOG4105CHC	glucokinase (EC 2.7.1.2)
NIES2134_114190	ENOG4108IJ6	ABC transporter
NIES2134_114210	ENOG41080E3	single-stranded DNA-binding protein
NIES2134_114220	ENOG4105D7V	transposase
NIES2134_114270	ENOG4107XSI	cobalt-precorrin-6y C15-methyltransferase
NIES2134_114290	ENOG4105DF7	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
NIES2134_114340	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
NIES2134_114380	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
NIES2134_114390	ENOG4108PPB	Seems to be required for the assembly of the photosystem I complex (By similarity)
NIES2134_114440	ENOG4105YVZ	photosystem II
NIES2134_114460	ENOG4105CVJ	phosphoglycerate mutase
NIES2134_114480	ENOG4105C9Q	fumarate hydratase class II
NIES2134_114510	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
NIES2134_114550	ENOG4105DB3	bacteriochlorophyll chlorophyll a synthase
NIES2134_114570	ENOG4105NT3	This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity)
NIES2134_114580	ENOG410689D	This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity)
NIES2134_114600	ENOG4106DN3	This protein is a component of the reaction center of photosystem II (By similarity)
NIES2134_114610	ENOG4105EQ7	Binding-protein-dependent transport systems, inner membrane component
NIES2134_114620	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
NIES2134_114630	ENOG4105DC1	bifunctional purine biosynthesis protein purh
NIES2134_114670	ENOG4108S1Y	allophycocyanin alpha-B chain
NIES2134_114680	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
NIES2134_114720	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
NIES2134_114750	ENOG4105CXT	aspartate transcarbamylase
NIES2134_114760	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
NIES2134_114780	ENOG4105CVN	desaturase
NIES2134_114810	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
NIES2134_114830	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
NIES2134_114850	ENOG41084GC	stage II sporulation protein
NIES2134_114860	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
NIES2134_114880	ENOG4108IUZ	ABC transporter
NIES2134_114940	ENOG4108VIA	integral membrane protein
NIES2134_114980	ENOG4105CNG	UPF0061 protein
NIES2134_115000	ENOG4105E9X	Photosystem II 44 kDa subunit reaction center protein
NIES2134_115010	ENOG4105D6H	One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity)
NIES2134_115020	ENOG41082QS	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
NIES2134_115060	ENOG4105CQB	FAD linked oxidase domain protein
NIES2134_115070	ENOG4107QRP	cobalamin biosynthesis protein CobW
NIES2134_115090	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
NIES2134_115110	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
NIES2134_115120	ENOG4105C1P	efflux transporter, rnd family, mfp subunit
NIES2134_115150	ENOG4107UAN	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
NIES2134_115160	ENOG4105CRE	cytochrome C
NIES2134_115180	ENOG4105C0D	helicase
NIES2134_115200	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
NIES2134_115240	ENOG4105DC8	reductase
NIES2134_115260	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
NIES2134_115290	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIES2134_115300	ENOG4105C4M	(Ubiquinol oxidase) subunit I
NIES2134_115310	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
NIES2134_115320	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
NIES2134_115350	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
NIES2134_115390	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
NIES2134_115410	ENOG4105E2K	Glycosyl transferase (Group 1
NIES2134_115420	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
NIES2134_115440	ENOG4105C5F	glutamine synthetase
NIES2134_115450	ENOG4105C3G	gtp-binding protein
NIES2134_115470	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
NIES2134_115490	ENOG4105CNI	cell division protein FtsW
NIES2134_115520	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
NIES2134_115530	ENOG4105C0H	protease
NIES2134_115550	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
NIES2134_115570	ENOG4105DZP	Membrane-associated zinc metalloprotease
NIES2134_115580	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
NIES2134_115610	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
NIES2134_115640	ENOG4105IBP	Cyclic peptide transporter
NIES2134_115650	ENOG4107RU9	Transcriptional regulator, Crp Fnr family
NIES2134_115740	ENOG4105BZU	Histidine kinase
NIES2134_115790	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
NIES2134_115800	ENOG4105EU8	FAD linked oxidase domain protein
NIES2134_115810	ENOG4105BZU	Histidine kinase
NIES2134_115830	ENOG4107U7Q	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
NIES2134_115920	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
NIES2134_115940	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
NIES2134_115950	ENOG4105C32	Amino acid ABC transporter (Permease)
NIES2134_115960	ENOG4105C9X	ppx gppa phosphatase
NIES2134_115990	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
NIES2134_116000	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
NIES2134_116020	ENOG4108R6K	riboflavin synthase, subunit alpha
NIES2134_116030	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
NIES2134_116040	ENOG4105CE9	30S ribosomal protein S2
NIES2134_116050	ENOG4107QJE	Chromosome Partitioning Protein
NIES2134_116060	ENOG4108IJ6	ABC transporter
NIES2134_116110	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
NIES2134_116130	ENOG4107SP2	The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity
NIES2134_116140	ENOG410828V	rubredoxin
NIES2134_116150	ENOG4105PW4	Sugar fermentation stimulation protein homolog
NIES2134_116160	ENOG4109025	Glyoxalase Bleomycin resistance protein (Dioxygenase
NIES2134_116170	ENOG4108P5B	Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity)
NIES2134_116220	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
NIES2134_116240	ENOG4108PWY	Carbohydrate-selective porin OprB
NIES2134_116250	ENOG4105W5Q	DNA repair protein (RadC
NIES2134_116260	ENOG4105CSR	polyphosphate kinase 2
NIES2134_116280	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
NIES2134_116290	ENOG4108XAD	Protein of unknown function (DUF1997)
NIES2134_116300	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
NIES2134_116320	ENOG4107RNB	anthranilate phosphoribosyltransferase
NIES2134_116340	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
NIES2134_116400	ENOG41066AK	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity)
NIES2134_116490	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
NIES2134_116500	ENOG4105CFG	Acts as a chaperone (By similarity)
NIES2134_116530	ENOG4105EGS	Mechanosensitive ion channel
NIES2134_116540	ENOG41083KH	UPF0102 protein
NIES2134_116550	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
NIES2134_116570	ENOG4105CE1	Ferrous iron transport protein b
NIES2134_116580	ENOG4105CE1	Ferrous iron transport protein b
NIES2134_116600	ENOG41090A1	ferritin
NIES2134_116620	ENOG4105JKW	Valine--pyruvate aminotransferase
NIES2134_116650	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
NIES2134_116670	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
NIES2134_116680	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
NIES2134_116690	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
NIES2134_116700	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
NIES2134_116710	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
NIES2134_116730	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
NIES2134_116750	ENOG4105E33	succinate dehydrogenase
NIES2134_116760	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
NIES2134_116790	ENOG4108KGH	TRANSCRIPTIONal
NIES2134_116800	ENOG41084IE	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
NIES2134_116840	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
NIES2134_116850	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
NIES2134_116860	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
NIES2134_116900	ENOG4105C19	ABC transporter
NIES2134_116930	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
NIES2134_116940	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
NIES2134_116950	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
NIES2134_116990	ENOG4105F4P	)-transporter
NIES2134_117070	ENOG4108R0D	protein with myosin-like
NIES2134_117090	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
NIES2134_117130	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
NIES2134_117140	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
NIES2134_117150	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
NIES2134_117180	ENOG4107QZ7	Cellulose synthase catalytic subunit
NIES2134_117190	ENOG4107QZ7	Cellulose synthase catalytic subunit
NIES2134_117210	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
NIES2134_117250	ENOG4105PNM	synthesis protein
NIES2134_117260	ENOG4105C2X	Arabinose 5-phosphate isomerase
NIES2134_117310	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
NIES2134_117320	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
NIES2134_117330	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
NIES2134_117350	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
NIES2134_117420	ENOG4108JPZ	Monovalent cation H antiporter subunit D
NIES2134_117440	ENOG4105C8S	subunit m
NIES2134_117490	ENOG4105C7K	acetolactate synthase
NIES2134_117500	ENOG4105KZX	Pterin carbinolamine dehydratase
NIES2134_117510	ENOG41082AF	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
NIES2134_117520	ENOG4105C8N	cysteinyl-tRNA synthetase
NIES2134_117530	ENOG41065E1	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
NIES2134_117570	ENOG4108790	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
NIES2134_117580	ENOG4105CFH	Aspartokinase
NIES2134_117590	ENOG4107Y9U	Membrane
NIES2134_117610	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
NIES2134_117650	ENOG4105C12	Phosphoribosylglycinamide synthetase
NIES2134_117670	ENOG4105C19	ABC transporter
NIES2134_117710	ENOG4106I2R	Coenzyme F420 hydrogenase dehydrogenase, beta
NIES2134_117730	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
NIES2134_117740	ENOG4105DR5	peptidase
NIES2134_117760	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
NIES2134_117790	ENOG4105CND	Glycosyl transferase, family 2
NIES2134_117800	ENOG4105CVA	phosphate
NIES2134_117830	ENOG4105BZU	Histidine kinase
NIES2134_117860	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
NIES2134_117910	ENOG4105CXN	decarboxylase
NIES2134_117920	ENOG41068XD	UPF0473 protein
NIES2134_117950	ENOG4105CV1	Transketolase (EC 2.2.1.1)
NIES2134_117970	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
NIES2134_117990	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
NIES2134_118010	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
NIES2134_118090	ENOG4105F0N	pyrophosphate phospho-hydrolase
NIES2134_118190	ENOG4105EMU	Dehydrogenase
NIES2134_118210	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
NIES2134_118260	ENOG4105CUT	histidyl-tRNA synthetase
NIES2134_118280	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
NIES2134_118300	ENOG4105DA5	(ABC) transporter
NIES2134_118310	ENOG4105WJF	
NIES2134_118360	ENOG4107E2E	PKHD-type hydroxylase
NIES2134_118380	ENOG4105BZU	Histidine kinase
NIES2134_118400	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
NIES2134_118420	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
NIES2134_118500	ENOG4105C59	p-type ATPase
NIES2134_118540	ENOG4105EJ9	Membrane
NIES2134_118550	ENOG4105C3M	thioredoxin reductase
NIES2134_118560	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
NIES2134_118580	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
NIES2134_118590	ENOG4108UHU	Aldolase
NIES2134_118650	ENOG4105CHV	Transcription elongation factor NusA
NIES2134_118660	ENOG4107ZR3	Required for maturation of 30S ribosomal subunits (By similarity)
NIES2134_118690	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
NIES2134_118740	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
NIES2134_118750	ENOG4107SWE	Methyltransferase
NIES2134_118760	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
NIES2134_118780	ENOG4105CHW	UPF0052 protein
NIES2134_118800	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
NIES2134_118830	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
NIES2134_118840	ENOG4105D6V	phycocyanin beta subunit
NIES2134_118850	ENOG4108SDR	phycocyanin, alpha subunit
NIES2134_118860	ENOG4108MZQ	phycobilisome linker polypeptide
NIES2134_118870	ENOG4106DMB	CpcD phycobilisome linker domain protein
NIES2134_118880	ENOG41078GB	pbs lyase
NIES2134_118890	ENOG4108V9J	phycocyanobilin lyase
NIES2134_118900	ENOG4106BTU	phycobilisome rod-core linker polypeptide
NIES2134_118910	ENOG4106BTU	phycobilisome rod-core linker polypeptide
NIES2134_118920	ENOG4106Q05	Rod-core linker protein required for attachment of phycocyanin to allophycocyanin in cores of phycobilisomes (By similarity)
NIES2134_118940	ENOG4105ZDH	Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna (By similarity)
NIES2134_118960	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
NIES2134_118970	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
NIES2134_119010	ENOG4107RFW	hydrolase family 57
NIES2134_119030	ENOG4105D7V	transposase
NIES2134_119040	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
NIES2134_119050	ENOG4107RH8	nuclease SbcCD subunit D
NIES2134_119090	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
NIES2134_119110	ENOG4107YD0	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
NIES2134_119140	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
NIES2134_119160	ENOG4108TQ9	Histidine kinase
NIES2134_119180	ENOG4105CDA	abc transporter atp-binding protein
NIES2134_119210	ENOG4105VZ9	UPF0235 protein
NIES2134_119230	ENOG4105C31	Tryptophanyl-tRNA synthetase
NIES2134_119260	ENOG4105BZU	Histidine kinase
NIES2134_119320	ENOG4108IV0	ABC, transporter
NIES2134_119430	ENOG4107XW6	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
NIES2134_119450	ENOG41083CN	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
NIES2134_119470	ENOG4105CXI	aluminum resistance protein
NIES2134_119560	ENOG4105D7N	magnesium and cobalt transport protein CorA
NIES2134_119590	ENOG4108N5B	2-phosphosulfolactate phosphatase
NIES2134_119670	ENOG4107ZYR	domain protein
NIES2134_119710	ENOG4105C26	Dehydrogenase
NIES2134_119730	ENOG4105BZF	Glycosyl transferase (Group 1
NIES2134_119760	ENOG4105CAU	Arsenical resistance protein, ArsH
NIES2134_119770	ENOG4105D52	delta-aminolevulinic acid dehydratase
NIES2134_119820	ENOG4105WN5	stage II sporulation protein
NIES2134_119830	ENOG4108420	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NIES2134_119850	ENOG4107SM1	it plays a direct role in the translocation of protons across the membrane (By similarity)
NIES2134_119860	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
NIES2134_119870	ENOG4105S30	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
NIES2134_119880	ENOG4105VYJ	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
NIES2134_119890	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
NIES2134_119900	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
NIES2134_119940	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
NIES2134_119960	ENOG4108JQ6	ABC transporter
NIES2134_120000	ENOG4105GHY	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity)
NIES2134_120030	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
NIES2134_120040	ENOG4105K8N	protein family UPF0079, ATPase
NIES2134_120060	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
NIES2134_120070	ENOG4105CAK	Cell division ATP-binding protein ftsE
NIES2134_120090	ENOG4105D6H	One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity)
NIES2134_120100	ENOG4105D7V	transposase
NIES2134_120110	ENOG4108RS6	transposase
NIES2134_120120	ENOG4108URP	Dtdp-4-dehydrorhamnose 3,5-epimerase
NIES2134_120160	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
NIES2134_120170	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
NIES2134_120190	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
NIES2134_120230	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
NIES2134_120240	ENOG4105D7V	transposase
NIES2134_120250	ENOG4108RS6	transposase
NIES2134_120280	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_120300	ENOG4105CQC	Prephenate dehydratase
NIES2134_120310	ENOG4105DCF	alanine dehydrogenase
NIES2134_120330	ENOG4105EMN	RNA polymerase sigma factor
NIES2134_120350	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
NIES2134_120380	ENOG4105C0Z	ABC transporter
NIES2134_120400	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
NIES2134_120420	ENOG4105W8V	TRANSCRIPTIONAl REGULATOR GntR family
NIES2134_120430	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
NIES2134_120440	ENOG4105ECY	inositol monophosphatase
NIES2134_120480	ENOG4105D65	subunit l
NIES2134_120490	ENOG4105C8S	subunit m
NIES2134_120510	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
NIES2134_120520	ENOG4105ESV	Glycosyl transferase, family 4
NIES2134_120530	ENOG4105CEV	competence damage-inducible protein
NIES2134_120570	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
NIES2134_120620	ENOG4108ISE	4Fe-4S ferredoxin, iron-sulfur binding
NIES2134_120680	ENOG4105CHH	sulfate transporter
NIES2134_120700	ENOG4108VX5	3-methyladenine DNA glycosylase
NIES2134_120730	ENOG4108KBA	Acts as a chaperone (By similarity)
NIES2134_120770	ENOG4105DR5	peptidase
NIES2134_120780	ENOG4108DIF	synthase (EC 4.2.1.75)
NIES2134_120790	ENOG4108SMZ	Covalently attaches a chromophore to Cys residue(s) of phycobiliproteins (By similarity)
NIES2134_120800	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
NIES2134_120810	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
NIES2134_120820	ENOG41084A0	50s ribosomal protein L35
NIES2134_120840	ENOG4105DBK	s4 domain protein
NIES2134_120880	ENOG4105C8U	phosphate abc transporter
NIES2134_120890	ENOG4105C8U	phosphate abc transporter
NIES2134_120900	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
NIES2134_120920	ENOG4107RRY	Cyanophycin synthetase
NIES2134_120960	ENOG4105D7V	transposase
NIES2134_120970	ENOG4108RS6	transposase
NIES2134_120980	ENOG4105EYH	Exonuclease
NIES2134_121010	ENOG4105CHR	reductase
NIES2134_121080	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
NIES2134_121090	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
NIES2134_121100	ENOG4105K4H	Nlp p60 protein
NIES2134_121110	ENOG4107QVP	Dehydrogenase
NIES2134_121130	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
NIES2134_121140	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
NIES2134_121210	ENOG4108R6G	acetyltransferase
NIES2134_121220	ENOG4108RCM	Nitroreductase
NIES2134_121230	ENOG4105C22	threonyL-tRNA synthetase
NIES2134_121240	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
NIES2134_121250	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
NIES2134_121260	ENOG4105C8A	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)
NIES2134_121270	ENOG4105CMR	udp-glucose 4-epimerase
NIES2134_121290	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
NIES2134_121300	ENOG4105FFC	UPF0187 protein
NIES2134_121320	ENOG4105D7V	transposase
NIES2134_121330	ENOG4108RS6	transposase
NIES2134_121370	ENOG4105C9I	Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB
NIES2134_121380	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
NIES2134_121410	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
NIES2134_121440	ENOG4105D9P	serine threonine protein kinase
NIES2134_121460	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
NIES2134_121480	ENOG4105DZR	Type I site-specific deoxyribonuclease
NIES2134_121510	ENOG41082EK	Restriction modification system DNA (Specificity
NIES2134_121540	ENOG4105CVR	type I restriction-modification system
NIES2134_121570	ENOG4107XHR	Involved in DNA repair and RecF pathway recombination (By similarity)
NIES2134_121590	ENOG4107SGM	protein serine threonine phosphatase
NIES2134_121600	ENOG4108RS6	transposase
NIES2134_121610	ENOG4105D7V	transposase
NIES2134_121630	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
NIES2134_121660	ENOG4108ZF3	Phosphatase
NIES2134_121680	ENOG4106D5S	Corrinoid adenosyltransferase BtuR CobO CobP
NIES2134_121780	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
NIES2134_121790	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
NIES2134_121800	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
NIES2134_121810	ENOG4105VFU	Rna-binding protein
NIES2134_121820	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
NIES2134_121830	ENOG4105WXN	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
NIES2134_121850	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
NIES2134_121860	ENOG4105C9S	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)
NIES2134_121870	ENOG4105D3R	alkyl hydroperoxide reductase
NIES2134_121910	ENOG4107RAQ	aminopeptidase
NIES2134_121920	ENOG4105CIH	Imidazole acetol-phosphate transaminase
NIES2134_121930	ENOG4105K70	DNA-binding protein
NIES2134_121940	ENOG4105BZA	Phosphoglycerate kinase
NIES2134_121980	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
NIES2134_122020	ENOG4105CKI	cobalamin synthesis protein
NIES2134_122050	ENOG4105F8J	Adenylate Guanylate cyclase
NIES2134_122120	ENOG4106MP8	UPF0754 membrane protein
NIES2134_122150	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
NIES2134_122160	ENOG4105JHY	Membrane
NIES2134_122190	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
NIES2134_122210	ENOG4105C8M	UPF0272 protein
NIES2134_122270	ENOG4108ZIT	Ferredoxin, 2FE-2S
NIES2134_122300	ENOG4107XWB	Zinc finger, swim domain protein
NIES2134_122310	ENOG4108K7V	UPF0284 protein
NIES2134_122330	ENOG4105E67	Catalyzes the four-electron reduction of biliverdin IX- alpha (2-electron reduction at both the A and D rings)
NIES2134_122350	ENOG4105ERG	peptidase m48, ste24p
NIES2134_122380	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
NIES2134_122400	ENOG4108UW5	maltose o-acetyltransferase
NIES2134_122410	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
NIES2134_122480	ENOG4107S6X	Glycosyl transferase, family 2
NIES2134_122520	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
NIES2134_122530	ENOG4108RS6	transposase
NIES2134_122540	ENOG4105D7V	transposase
NIES2134_122550	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
NIES2134_122570	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
NIES2134_122590	ENOG4105DUM	transcriptional regulator, lysR family
NIES2134_122620	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
NIES2134_122650	ENOG4105F0I	Aminotransferase
NIES2134_122670	ENOG4105CEZ	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)
NIES2134_122680	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
NIES2134_122690	ENOG41084W5	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
NIES2134_122710	ENOG4105DFH	Transport of potassium into the cell (By similarity)
NIES2134_122720	ENOG4105CHM	Aminotransferase
NIES2134_122740	ENOG4106DDF	Photosystem II reaction center protein M
NIES2134_122770	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
NIES2134_122800	ENOG4105F23	Fibronectin-binding protein
NIES2134_122820	ENOG41084GG	50S ribosomal protein L33
NIES2134_122830	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
NIES2134_122840	ENOG4105DSE	periplasmic solute binding protein
NIES2134_122850	ENOG4105FDK	ABC transporter
NIES2134_122880	ENOG4105D74	hydrolase
NIES2134_122940	ENOG4105D7V	transposase
NIES2134_122960	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
NIES2134_123060	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
NIES2134_123120	ENOG4105K63	Thioredoxin
NIES2134_123140	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
NIES2134_123150	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
NIES2134_123180	ENOG4105CE4	GlcNAc 6-P deacetylase
NIES2134_123190	ENOG4108M11	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
NIES2134_123230	ENOG4105C8T	Leucyl-tRNA synthetase
NIES2134_123240	ENOG4105ETX	regulatoR
NIES2134_123280	ENOG4105KRF	dihydroneopterin aldolase
NIES2134_123290	ENOG4105C7Z	Conserved Protein
NIES2134_123300	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
NIES2134_123340	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
NIES2134_123350	ENOG4105CD2	stage iii sporulation protein aa
NIES2134_123370	ENOG4105CT2	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
NIES2134_123380	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
NIES2134_123510	ENOG41082EZ	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
NIES2134_123530	ENOG4105D65	subunit l
NIES2134_123540	ENOG4105C8S	subunit m
NIES2134_123560	ENOG4105C89	phosphohexose isomerase
NIES2134_123580	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
NIES2134_123610	ENOG4105CDH	Citrulline--aspartate ligase
NIES2134_123620	ENOG4105C5I	Dehydrogenase
NIES2134_123670	ENOG41060PQ	electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity)
NIES2134_123680	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
NIES2134_123690	ENOG4105D44	asparaginase
NIES2134_123720	ENOG4105EXX	Deoxyribodipyrimidine photolyase-related protein
NIES2134_123730	ENOG4105DK0	Indole-3-glycerol phosphate synthase
NIES2134_123740	ENOG4107YBY	Hydrolase
NIES2134_123750	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
NIES2134_123760	ENOG4105W8H	transhydrogenase (subunit alpha
NIES2134_123770	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
NIES2134_123780	ENOG41068KF	Universal stress protein
NIES2134_123790	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
NIES2134_123800	ENOG4105BZ1	(ABC) transporter
NIES2134_123810	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
NIES2134_123840	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
NIES2134_123850	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
NIES2134_123890	ENOG4107RTD	sua5 ycio yrdc ywlc family protein
NIES2134_123900	ENOG4105CVB	Vitamin K epoxide reductase
NIES2134_123980	ENOG4105D7V	transposase
NIES2134_123990	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
NIES2134_124000	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
NIES2134_124030	ENOG4105C4A	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)
NIES2134_124050	ENOG4107WZZ	SMC domain protein
NIES2134_124120	ENOG4107QHF	type ii secretion system protein e
NIES2134_124130	ENOG4105CZX	twitching motility protein
NIES2134_124150	ENOG4105DVC	DnaJ domain protein
NIES2134_124180	ENOG4105C3J	Cysteine desulfurase
NIES2134_124190	ENOG4105EKQ	RNA-directed DNA polymerase
NIES2134_124220	ENOG4105DWY	Agmatine deiminase
NIES2134_124230	ENOG41082HT	Binds the 23S rRNA (By similarity)
NIES2134_124240	ENOG4108UJD	30S ribosomal protein S9
NIES2134_124250	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
NIES2134_124260	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
NIES2134_124270	ENOG4108ZT0	50S ribosomal protein l17
NIES2134_124280	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
NIES2134_124290	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
NIES2134_124300	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NIES2134_124310	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
NIES2134_124320	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
NIES2134_124330	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
NIES2134_124340	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
NIES2134_124350	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
NIES2134_124360	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
NIES2134_124370	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
NIES2134_124380	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
NIES2134_124390	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NIES2134_124400	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
NIES2134_124410	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
NIES2134_124420	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
NIES2134_124430	ENOG410848H	50s ribosomal protein l29
NIES2134_124440	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
NIES2134_124450	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
NIES2134_124460	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
NIES2134_124470	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
NIES2134_124480	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NIES2134_124490	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
NIES2134_124500	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
NIES2134_124510	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
NIES2134_124520	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
NIES2134_124560	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
NIES2134_124590	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
NIES2134_124640	ENOG4105DKQ	ROK family
NIES2134_124650	ENOG4108KGH	TRANSCRIPTIONal
NIES2134_124660	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NIES2134_124680	ENOG4105BZU	Histidine kinase
NIES2134_124700	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
NIES2134_124730	ENOG4105DSM	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)
NIES2134_124750	ENOG4105C78	Uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent (By similarity)
NIES2134_124760	ENOG4105E4G	Type IV pilus
NIES2134_124800	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
NIES2134_124820	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
NIES2134_124830	ENOG4105C7N	Xanthine uracil vitamin C permease
NIES2134_124880	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
NIES2134_124890	ENOG4105KC4	UPF0296 protein
NIES2134_124900	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
NIES2134_124910	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
NIES2134_124930	ENOG4105C9B	Cysteine desulfurase
NIES2134_124940	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
NIES2134_124960	ENOG4108PWY	Carbohydrate-selective porin OprB
NIES2134_125010	ENOG4105KHC	sulfurtransferase
NIES2134_125030	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
NIES2134_125060	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
NIES2134_125100	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
NIES2134_125110	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
NIES2134_125130	ENOG4105ETX	regulatoR
NIES2134_125150	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
NIES2134_125200	ENOG4108IPT	Naphthoate synthase
NIES2134_125250	ENOG41083EU	50s ribosomal protein l28
NIES2134_125270	ENOG4105J0U	photosystem II
NIES2134_125280	ENOG4108UV1	cellular component movement
NIES2134_125290	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
NIES2134_125360	ENOG4105C5S	asparaginyl-tRNA synthetase
NIES2134_125380	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
NIES2134_125400	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase