locus-tag	class	description
NIES2134_100030	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES2134_100050	COG0804	urea catabolic process
NIES2134_100080	COG4956	integral membrane protein (PIN domain superfamily)
NIES2134_100130	COG1473	amidohydrolase
NIES2134_100150	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
NIES2134_100160	COG2211	Major facilitator Superfamily
NIES2134_100190	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NIES2134_100210	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NIES2134_100290	COG2205	protein histidine kinase activity
NIES2134_100330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIES2134_100370	COG0463	Glycosyl transferase, family 2
NIES2134_100370	COG0457	Tetratricopeptide repeat
NIES2134_100390	COG0811	peptide transport
NIES2134_100400	COG1595	DNA-templated transcription, initiation
NIES2134_100460	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
NIES2134_100480	COG0484	heat shock protein binding
NIES2134_100490	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NIES2134_100500	COG2264	protein methyltransferase activity
NIES2134_100510	COG0438	transferase activity, transferring glycosyl groups
NIES2134_100540	COG0832	Belongs to the urease beta subunit family
NIES2134_100550	COG0259	pyridoxamine-phosphate oxidase activity
NIES2134_100570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NIES2134_100580	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NIES2134_100610	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NIES2134_100630	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIES2134_100650	COG0429	hydrolase of the alpha beta-hydrolase fold
NIES2134_100680	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NIES2134_100730	COG0840	transmembrane signaling receptor activity
NIES2134_100750	COG4581	dead DEAH box helicase
NIES2134_100820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIES2134_100860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NIES2134_100940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NIES2134_100950	COG0484	heat shock protein binding
NIES2134_100960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NIES2134_100980	COG0460	homoserine dehydrogenase
NIES2134_100990	COG4208	sulfate ABC transporter
NIES2134_101000	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
NIES2134_101010	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
NIES2134_101030	COG1429	ligase activity, forming nitrogen-metal bonds
NIES2134_101040	COG1122	ATPase activity
NIES2134_101060	COG0861	Integral membrane protein TerC family
NIES2134_101070	COG0105	UTP biosynthetic process
NIES2134_101080	COG0384	phenazine biosynthesis protein PhzF
NIES2134_101100	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES2134_101110	COG2268	Band 7 protein
NIES2134_101120	COG2268	Band 7 protein
NIES2134_101140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NIES2134_101140	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NIES2134_101170	COG1473	amidohydrolase
NIES2134_101200	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NIES2134_101230	COG0310	cobalt ion transport
NIES2134_101240	COG1930	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import
NIES2134_101260	COG1122	ATPase activity
NIES2134_101290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES2134_101300	COG0287	Prephenate dehydrogenase
NIES2134_101330	COG0515	serine threonine protein kinase
NIES2134_101350	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES2134_101350	COG0515	serine threonine protein kinase
NIES2134_101390	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NIES2134_101430	COG1252	NADH dehydrogenase
NIES2134_101440	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
NIES2134_101500	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NIES2134_101520	COG0668	transmembrane transport
NIES2134_101530	COG2081	HI0933 family
NIES2134_101550	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NIES2134_101570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NIES2134_101580	COG0745	RESPONSE REGULATOR receiver
NIES2134_101600	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
NIES2134_101630	COG0596	Alpha beta hydrolase
NIES2134_101640	COG3706	GGDEF domain
NIES2134_101650	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NIES2134_101670	COG1716	ATPase activity
NIES2134_101680	COG0515	serine threonine protein kinase
NIES2134_101720	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NIES2134_101830	COG1131	(ABC) transporter
NIES2134_101850	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIES2134_101850	COG0512	Glutamine amidotransferase of anthranilate synthase
NIES2134_101940	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NIES2134_101960	COG0515	serine threonine protein kinase
NIES2134_101960	COG3266	domain, Protein
NIES2134_102000	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NIES2134_102030	COG0450	alkyl hydroperoxide reductase
NIES2134_102060	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_102090	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NIES2134_102120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
NIES2134_102140	COG0724	RNA recognition motif
NIES2134_102170	COG0678	peroxiredoxin activity
NIES2134_102170	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES2134_102210	COG3118	belongs to the thioredoxin family
NIES2134_102230	COG0747	negative chemotaxis
NIES2134_102240	COG3956	TIGRFAM MazG family protein
NIES2134_102250	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NIES2134_102300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIES2134_102320	COG0514	ATP-dependent DNA helicase (RecQ)
NIES2134_102390	COG1666	GTP binding
NIES2134_102410	COG0443	Heat shock 70 kDa protein
NIES2134_102420	COG0484	heat shock protein binding
NIES2134_102450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIES2134_102480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NIES2134_102490	COG2223	nitrite transmembrane transporter activity
NIES2134_102500	COG0058	SHG alpha-glucan phosphorylase activity
NIES2134_102520	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NIES2134_102550	COG0442	prolyl-tRNA aminoacylation
NIES2134_102570	COG0697	spore germination
NIES2134_102580	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NIES2134_102610	COG0504	CTP synthase activity
NIES2134_102620	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
NIES2134_102640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIES2134_102640	COG0574	Belongs to the PEP-utilizing enzyme family
NIES2134_102650	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NIES2134_102660	COG0297	glycogen (starch) synthase activity
NIES2134_102680	COG1420	regulation of RNA biosynthetic process
NIES2134_102690	COG0505	Belongs to the CarA family
NIES2134_102700	COG1175	transmembrane transport
NIES2134_102710	COG0484	heat shock protein binding
NIES2134_102770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIES2134_102870	COG0436	Aminotransferase
NIES2134_102880	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NIES2134_102890	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NIES2134_102920	COG3706	GGDEF domain
NIES2134_102920	COG2203	Gaf domain
NIES2134_102920	COG4251	negative regulation of phosphorylation
NIES2134_102920	COG5001	Diguanylate cyclase
NIES2134_102930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NIES2134_102940	COG2205	protein histidine kinase activity
NIES2134_102960	COG4251	negative regulation of phosphorylation
NIES2134_102970	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
NIES2134_102980	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIES2134_102990	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
NIES2134_103020	COG0824	Thioesterase
NIES2134_103040	COG0719	Fe-S assembly protein
NIES2134_103090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NIES2134_103100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NIES2134_103120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES2134_103140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES2134_103150	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NIES2134_103160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIES2134_103170	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NIES2134_103180	COG1959	2 iron, 2 sulfur cluster binding
NIES2134_103190	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NIES2134_103210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NIES2134_103220	COG1834	amidinotransferase
NIES2134_103230	COG0544	peptidyl-prolyl cis-trans isomerase activity
NIES2134_103240	COG0740	serine-type endopeptidase activity
NIES2134_103250	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NIES2134_103300	COG2226	methyltransferase
NIES2134_103310	COG0589	response to stress
NIES2134_103340	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NIES2134_103370	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NIES2134_103380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES2134_103380	COG0237	dephospho-CoA kinase activity
NIES2134_103390	COG0745	RESPONSE REGULATOR receiver
NIES2134_103440	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES2134_103450	COG0463	Glycosyl transferase, family 2
NIES2134_103470	COG0436	Aminotransferase
NIES2134_103480	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NIES2134_103500	COG2022	thiamine diphosphate biosynthetic process
NIES2134_103550	COG0420	3'-5' exonuclease activity
NIES2134_103570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES2134_103580	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
NIES2134_103590	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NIES2134_103600	COG0848	biopolymer transport protein
NIES2134_103610	COG0194	GDP metabolic process
NIES2134_103640	COG0612	Peptidase, M16
NIES2134_103650	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NIES2134_103660	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
NIES2134_103680	COG0735	belongs to the Fur family
NIES2134_103700	COG1619	proteins homologs of microcin C7 resistance protein MccF
NIES2134_103710	COG1007	ATP synthesis coupled electron transport
NIES2134_103720	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIES2134_103720	COG0425	Belongs to the sulfur carrier protein TusA family
NIES2134_103740	COG0204	Acyl-transferase
NIES2134_103740	COG0318	PFAM AMP-dependent synthetase and ligase
NIES2134_103750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NIES2134_103760	COG0228	four-way junction DNA binding
NIES2134_103780	COG0828	Belongs to the bacterial ribosomal protein bS21 family
NIES2134_103790	COG1702	phosphate starvation-inducible protein PhoH
NIES2134_103840	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
NIES2134_103860	COG0542	response to heat
NIES2134_103890	COG0481	GTPase activity
NIES2134_103910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NIES2134_103960	COG0328	RNA-DNA hybrid ribonuclease activity
NIES2134_103970	COG0222	ribosome binding
NIES2134_103980	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NIES2134_103990	COG0081	regulation of translation
NIES2134_104000	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
NIES2134_104010	COG0250	Participates in transcription elongation, termination and antitermination
NIES2134_104060	COG0629	single-stranded DNA binding
NIES2134_104070	COG0446	pyridine nucleotide-disulphide oxidoreductase
NIES2134_104100	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES2134_104110	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NIES2134_104120	COG1842	Phage shock protein A
NIES2134_104140	COG0312	modulator of DNA gyrase
NIES2134_104150	COG5398	heme oxygenase
NIES2134_104160	COG0165	Argininosuccinate lyase
NIES2134_104190	COG0463	Glycosyl transferase, family 2
NIES2134_104190	COG0457	Tetratricopeptide repeat
NIES2134_104200	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NIES2134_104210	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NIES2134_104310	COG2119	membrane
NIES2134_104330	COG2385	sporulation resulting in formation of a cellular spore
NIES2134_104350	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NIES2134_104380	COG1943	Transposase
NIES2134_104420	COG3411	Ferredoxin
NIES2134_104480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NIES2134_104490	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NIES2134_104510	COG1959	2 iron, 2 sulfur cluster binding
NIES2134_104550	COG2082	Precorrin-8x methylmutase
NIES2134_104570	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIES2134_104570	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIES2134_104580	COG0217	transcriptional regulatory protein
NIES2134_104600	COG0590	tRNA wobble adenosine to inosine editing
NIES2134_104610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NIES2134_104620	COG0434	BtpA family
NIES2134_104630	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NIES2134_104640	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NIES2134_104650	COG0484	heat shock protein binding
NIES2134_104660	COG0788	formyltetrahydrofolate deformylase activity
NIES2134_104670	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NIES2134_104680	COG0459	protein refolding
NIES2134_104690	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
NIES2134_104700	COG0395	ABC-type sugar transport system, permease component
NIES2134_104710	COG0004	ammonium transporteR
NIES2134_104730	COG0285	dihydrofolate synthase activity
NIES2134_104750	COG0735	belongs to the Fur family
NIES2134_104780	COG2205	protein histidine kinase activity
NIES2134_104850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIES2134_104860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NIES2134_104870	COG0022	dehydrogenase e1 component
NIES2134_104870	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIES2134_104890	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NIES2134_104900	COG0625	glutathione transferase activity
NIES2134_104920	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NIES2134_104920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NIES2134_104940	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NIES2134_104950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NIES2134_104960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
NIES2134_104970	COG1132	(ABC) transporter
NIES2134_104980	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NIES2134_105000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NIES2134_105020	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
NIES2134_105030	COG1012	belongs to the aldehyde dehydrogenase family
NIES2134_105040	COG4178	(ABC) transporter
NIES2134_105060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
NIES2134_105070	COG1012	belongs to the aldehyde dehydrogenase family
NIES2134_105070	COG1454	alcohol dehydrogenase
NIES2134_105080	COG0095	Lipoate-protein ligase
NIES2134_105110	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NIES2134_105130	COG0140	phosphoribosyl-ATP diphosphatase activity
NIES2134_105130	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NIES2134_105220	COG1215	transferase activity, transferring glycosyl groups
NIES2134_105230	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
NIES2134_105240	COG0438	transferase activity, transferring glycosyl groups
NIES2134_105360	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES2134_105360	COG2247	cell wall binding repeat
NIES2134_105410	COG1943	Transposase
NIES2134_105430	COG1049	propionate catabolic process, 2-methylcitrate cycle
NIES2134_105450	COG1192	Involved in chromosome partitioning
NIES2134_105460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NIES2134_105480	COG1376	ErfK ybiS ycfS ynhG family protein
NIES2134_105500	COG0408	coproporphyrinogen oxidase activity
NIES2134_105510	COG1333	cytochrome c biogenesis protein
NIES2134_105650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES2134_105660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES2134_105670	COG0713	ATP synthesis coupled electron transport
NIES2134_105680	COG0839	Belongs to the complex I subunit 6 family
NIES2134_105690	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_105700	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
NIES2134_105710	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIES2134_105720	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES2134_105730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NIES2134_105740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NIES2134_105750	COG0072	phenylalanine-tRNA ligase activity
NIES2134_105750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NIES2134_105760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NIES2134_105790	COG1943	Transposase
NIES2134_105810	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NIES2134_105820	COG0148	phosphopyruvate hydratase activity
NIES2134_105830	COG2217	Heavy metal translocating P-type atpase
NIES2134_105840	COG1187	pseudouridine synthase activity
NIES2134_105860	COG1132	(ABC) transporter
NIES2134_105890	COG0557	exoribonuclease II activity
NIES2134_105930	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NIES2134_105940	COG1372	Participates in initiation and elongation during chromosome replication
NIES2134_105940	COG0187	DNA topoisomerase II activity
NIES2134_105960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES2134_105980	COG0577	efflux transmembrane transporter activity
NIES2134_105980	COG1136	(ABC) transporter
NIES2134_105990	COG0085	RNA polymerase activity
NIES2134_106000	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NIES2134_106010	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NIES2134_106020	COG0501	Belongs to the peptidase M48B family
NIES2134_106080	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
NIES2134_106090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES2134_106130	COG0612	Peptidase, M16
NIES2134_106140	COG5001	Diguanylate cyclase
NIES2134_106140	COG1716	ATPase activity
NIES2134_106170	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NIES2134_106200	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NIES2134_106270	COG1943	Transposase
NIES2134_106290	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NIES2134_106290	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NIES2134_106330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NIES2134_106340	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NIES2134_106370	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NIES2134_106420	COG0515	serine threonine protein kinase
NIES2134_106420	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES2134_106510	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NIES2134_106530	COG0426	domain, Protein
NIES2134_106530	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES2134_106540	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
NIES2134_106610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NIES2134_106640	COG0363	glucosamine-6-phosphate deaminase activity
NIES2134_106690	COG0740	serine-type endopeptidase activity
NIES2134_106700	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
NIES2134_106710	COG0765	amino acid transport
NIES2134_106740	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NIES2134_106750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NIES2134_106800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NIES2134_106840	COG0129	dihydroxy-acid dehydratase activity
NIES2134_106850	COG2099	Precorrin-6x reductase
NIES2134_106870	COG0667	Aldo Keto reductase
NIES2134_106880	COG0742	ribosomal rna small subunit methyltransferase
NIES2134_106940	COG0745	RESPONSE REGULATOR receiver
NIES2134_106950	COG0438	transferase activity, transferring glycosyl groups
NIES2134_106970	COG2226	methyltransferase
NIES2134_106970	COG1073	alpha beta
NIES2134_107000	COG1472	Belongs to the glycosyl hydrolase 3 family
NIES2134_107010	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES2134_107020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NIES2134_107030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NIES2134_107060	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NIES2134_107140	COG0175	sulfate reduction
NIES2134_107150	COG0752	glycyl-tRNA synthetase alpha subunit
NIES2134_107160	COG0726	polysaccharide deacetylase
NIES2134_107180	COG0163	prenyltransferase activity
NIES2134_107200	COG0702	epimerase
NIES2134_107220	COG1410	methionine synthase
NIES2134_107220	COG0646	methionine synthase
NIES2134_107240	COG2010	Cytochrome c
NIES2134_107260	COG0463	Glycosyl transferase, family 2
NIES2134_107260	COG0457	Tetratricopeptide repeat
NIES2134_107270	COG0784	Response regulator, receiver
NIES2134_107270	COG2198	Histidine kinase
NIES2134_107270	COG5002	protein histidine kinase activity
NIES2134_107280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NIES2134_107300	COG0745	RESPONSE REGULATOR receiver
NIES2134_107320	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NIES2134_107330	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NIES2134_107340	COG0489	protein tyrosine kinase activity
NIES2134_107350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIES2134_107350	COG0519	Catalyzes the synthesis of GMP from XMP
NIES2134_107380	COG0305	Participates in initiation and elongation during chromosome replication
NIES2134_107380	COG1372	Participates in initiation and elongation during chromosome replication
NIES2134_107380	COG0305	Participates in initiation and elongation during chromosome replication
NIES2134_107380	COG1372	Participates in initiation and elongation during chromosome replication
NIES2134_107430	COG1555	photosystem II stabilization
NIES2134_107440	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NIES2134_107540	COG1943	Transposase
NIES2134_107560	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
NIES2134_107570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
NIES2134_107570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NIES2134_107580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIES2134_107590	COG0372	Belongs to the citrate synthase family
NIES2134_107600	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES2134_107620	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
NIES2134_107640	COG0438	transferase activity, transferring glycosyl groups
NIES2134_107690	COG3385	transposase activity
NIES2134_107700	COG1836	PFAM Integral membrane protein DUF92
NIES2134_107710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NIES2134_107720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NIES2134_107770	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
NIES2134_107790	COG1840	ABC-type Fe3 transport system, periplasmic component
NIES2134_107840	COG0469	pyruvate kinase activity
NIES2134_107850	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES2134_107860	COG0470	DNA polymerase III
NIES2134_107870	COG0617	tRNA 3'-terminal CCA addition
NIES2134_107900	COG1181	Belongs to the D-alanine--D-alanine ligase family
NIES2134_107920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NIES2134_107930	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NIES2134_107940	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
NIES2134_107950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES2134_107960	COG0312	modulator of DNA gyrase
NIES2134_107970	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NIES2134_107980	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
NIES2134_108000	COG0632	four-way junction helicase activity
NIES2134_108030	COG0445	tRNA wobble uridine modification
NIES2134_108040	COG0829	nickel cation binding
NIES2134_108070	COG3409	Peptidoglycan-binding domain 1 protein
NIES2134_108070	COG3429	Glucose-6-phosphate dehydrogenase subunit
NIES2134_108080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NIES2134_108090	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
NIES2134_108160	COG2172	sigma factor antagonist activity
NIES2134_108180	COG4251	negative regulation of phosphorylation
NIES2134_108220	COG1132	(ABC) transporter
NIES2134_108250	COG0693	protein deglycase activity
NIES2134_108270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NIES2134_108280	COG0123	including yeast histone deacetylase and acetoin utilization protein
NIES2134_108340	COG0784	Response regulator, receiver
NIES2134_108350	COG3659	wide pore channel activity
NIES2134_108360	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIES2134_108380	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NIES2134_108390	COG1132	(ABC) transporter
NIES2134_108400	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NIES2134_108410	COG0167	dihydroorotate dehydrogenase activity
NIES2134_108430	COG1122	ATPase activity
NIES2134_108440	COG0438	transferase activity, transferring glycosyl groups
NIES2134_108450	COG0574	Belongs to the PEP-utilizing enzyme family
NIES2134_108450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NIES2134_108460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NIES2134_108480	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NIES2134_108490	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NIES2134_108510	COG0745	RESPONSE REGULATOR receiver
NIES2134_108530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NIES2134_108550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NIES2134_108600	COG1530	ribonuclease E activity
NIES2134_108610	COG2066	Belongs to the glutaminase family
NIES2134_108630	COG0706	membrane insertase activity
NIES2134_108640	COG0594	ribonuclease P activity
NIES2134_108650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
NIES2134_108660	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NIES2134_108680	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NIES2134_108750	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES2134_108760	COG0701	Predicted permease
NIES2134_108770	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NIES2134_108780	COG0783	Belongs to the Dps family
NIES2134_108810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES2134_108830	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NIES2134_108840	COG0154	amidase activity
NIES2134_108860	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NIES2134_108960	COG1216	Glycosyl transferase, family 2
NIES2134_108980	COG0640	Transcriptional regulator
NIES2134_108990	COG4968	Prepilin-type N-terminal cleavage methylation domain
NIES2134_109020	COG0840	transmembrane signaling receptor activity
NIES2134_109020	COG2203	Gaf domain
NIES2134_109090	COG0411	ABC transporter
NIES2134_109100	COG0559	Belongs to the binding-protein-dependent transport system permease family
NIES2134_109110	COG0559	Belongs to the binding-protein-dependent transport system permease family
NIES2134_109130	COG0537	adenosine 5'-monophosphoramidase activity
NIES2134_109140	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NIES2134_109150	COG1216	Glycosyl transferase, family 2
NIES2134_109150	COG1442	glycosyl transferase family 8
NIES2134_109180	COG1216	Glycosyl transferase, family 2
NIES2134_109200	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NIES2134_109210	COG1882	Formate acetyltransferase
NIES2134_109240	COG1162	GTPase activity
NIES2134_109260	COG1253	flavin adenine dinucleotide binding
NIES2134_109280	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NIES2134_109290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIES2134_109300	COG0831	urea catabolic process
NIES2134_109310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NIES2134_109320	COG2048	Heterodisulfide reductase, subunit B
NIES2134_109330	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NIES2134_109370	COG4245	von Willebrand factor, type A
NIES2134_109390	COG4245	von Willebrand factor, type A
NIES2134_109460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIES2134_109470	COG1063	alcohol dehydrogenase
NIES2134_109480	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
NIES2134_109510	COG0149	triose-phosphate isomerase activity
NIES2134_109530	COG1192	Involved in chromosome partitioning
NIES2134_109540	COG1132	(ABC) transporter
NIES2134_109630	COG0805	protein transport
NIES2134_109640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NIES2134_109660	COG1091	dTDP-4-dehydrorhamnose reductase activity
NIES2134_109670	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES2134_109710	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES2134_109720	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
NIES2134_109730	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NIES2134_109730	COG4451	ribulose bisphosphate carboxylase, small
NIES2134_109750	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NIES2134_109800	COG1077	Cell shape determining protein MreB Mrl
NIES2134_109850	COG0741	lytic transglycosylase activity
NIES2134_109870	COG1028	Short-chain dehydrogenase reductase Sdr
NIES2134_109890	COG0436	Aminotransferase
NIES2134_109900	COG0552	protein localization to endoplasmic reticulum
NIES2134_109910	COG1218	3'(2'),5'-bisphosphate nucleotidase
NIES2134_109930	COG5002	protein histidine kinase activity
NIES2134_109940	COG4251	negative regulation of phosphorylation
NIES2134_109940	COG3706	GGDEF domain
NIES2134_109940	COG5001	Diguanylate cyclase
NIES2134_109940	COG2203	Gaf domain
NIES2134_109960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NIES2134_109980	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES2134_110000	COG0596	Alpha beta hydrolase
NIES2134_110030	COG1234	tRNA 3'-trailer cleavage
NIES2134_110030	COG1555	photosystem II stabilization
NIES2134_110070	COG1104	cysteine desulfurase activity
NIES2134_110110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NIES2134_110120	COG0189	ligase activity
NIES2134_110130	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES2134_110150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_110160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES2134_110210	COG2205	protein histidine kinase activity
NIES2134_110220	COG0237	dephospho-CoA kinase activity
NIES2134_110250	COG0602	queuosine metabolic process
NIES2134_110280	COG1116	anion transmembrane transporter activity
NIES2134_110290	COG0275	rRNA processing
NIES2134_110300	COG1116	anion transmembrane transporter activity
NIES2134_110330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NIES2134_110380	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NIES2134_110400	COG0440	acetolactate synthase activity
NIES2134_110420	COG1160	GTP binding
NIES2134_110430	COG5002	protein histidine kinase activity
NIES2134_110430	COG0784	Response regulator, receiver
NIES2134_110430	COG2205	protein histidine kinase activity
NIES2134_110440	COG0271	Belongs to the BolA IbaG family
NIES2134_110450	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
NIES2134_110460	COG0071	Belongs to the small heat shock protein (HSP20) family
NIES2134_110500	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
NIES2134_110510	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIES2134_110520	COG0316	Belongs to the HesB IscA family
NIES2134_110580	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
NIES2134_110610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NIES2134_110620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIES2134_110680	COG1045	serine acetyltransferase
NIES2134_110690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIES2134_110740	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NIES2134_110750	COG0416	fatty acid biosynthetic process
NIES2134_110760	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NIES2134_110810	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
NIES2134_110860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NIES2134_110870	COG0321	lipoyl(octanoyl) transferase activity
NIES2134_110880	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NIES2134_110900	COG3264	Mechanosensitive ion channel
NIES2134_110900	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NIES2134_110940	COG0018	arginyl-trna synthetase
NIES2134_110950	COG0717	Belongs to the dCTP deaminase family
NIES2134_110960	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NIES2134_110990	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIES2134_111010	COG1121	(ABC) transporter
NIES2134_111020	COG1899	peptidyl-lysine modification to peptidyl-hypusine
NIES2134_111040	COG2217	Heavy metal translocating P-type atpase
NIES2134_111050	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NIES2134_111050	COG0678	peroxiredoxin activity
NIES2134_111120	COG1063	alcohol dehydrogenase
NIES2134_111170	COG0758	DNA mediated transformation
NIES2134_111170	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NIES2134_111180	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_111190	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_111220	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES2134_111240	COG3063	Type IV pilus biogenesis stability protein PilW
NIES2134_111250	COG0412	Dienelactone hydrolase
NIES2134_111270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NIES2134_111300	COG0310	cobalt ion transport
NIES2134_111340	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES2134_111340	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES2134_111350	COG0459	protein refolding
NIES2134_111360	COG2340	Cysteine-rich secretory protein family
NIES2134_111390	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
NIES2134_111410	COG0793	Belongs to the peptidase S41A family
NIES2134_111420	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NIES2134_111440	COG1304	FMN binding
NIES2134_111460	COG0121	glutamine amidotransferase
NIES2134_111490	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NIES2134_111500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NIES2134_111580	COG0542	response to heat
NIES2134_111620	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NIES2134_111630	COG0193	aminoacyl-tRNA hydrolase activity
NIES2134_111640	COG0577	efflux transmembrane transporter activity
NIES2134_111640	COG1136	(ABC) transporter
NIES2134_111660	COG0395	ABC-type sugar transport system, permease component
NIES2134_111760	COG0426	domain, Protein
NIES2134_111760	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NIES2134_111790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NIES2134_111800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIES2134_111810	COG0070	glutamate synthase
NIES2134_111810	COG0069	glutamate synthase activity
NIES2134_111810	COG0067	glutamate synthase
NIES2134_111820	COG5002	protein histidine kinase activity
NIES2134_111820	COG0784	Response regulator, receiver
NIES2134_111830	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
NIES2134_111840	COG0830	nickel cation binding
NIES2134_111850	COG0303	'Molybdopterin
NIES2134_111860	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NIES2134_111870	COG0315	cyclic pyranopterin monophosphate synthase activity
NIES2134_111870	COG0746	molybdenum cofactor guanylyltransferase activity
NIES2134_111880	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NIES2134_111890	COG0314	molybdopterin synthase activity
NIES2134_111900	COG0583	DNA-binding transcription factor activity
NIES2134_111940	COG0243	molybdopterin cofactor binding
NIES2134_111950	COG1116	anion transmembrane transporter activity
NIES2134_111960	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES2134_111960	COG1116	anion transmembrane transporter activity
NIES2134_111970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES2134_111980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES2134_111990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NIES2134_112050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NIES2134_112100	COG0529	Catalyzes the synthesis of activated sulfate
NIES2134_112110	COG1716	ATPase activity
NIES2134_112110	COG0842	Transport permease protein
NIES2134_112110	COG1131	(ABC) transporter
NIES2134_112140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIES2134_112140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NIES2134_112150	COG0612	Peptidase, M16
NIES2134_112160	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
NIES2134_112220	COG0156	8-amino-7-oxononanoate synthase activity
NIES2134_112230	COG0745	RESPONSE REGULATOR receiver
NIES2134_112240	COG0842	Transport permease protein
NIES2134_112240	COG1131	(ABC) transporter
NIES2134_112240	COG1716	ATPase activity
NIES2134_112250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NIES2134_112270	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES2134_112270	COG0515	serine threonine protein kinase
NIES2134_112360	COG0358	DNA primase activity
NIES2134_112380	COG0205	6-phosphofructokinase activity
NIES2134_112390	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIES2134_112400	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NIES2134_112420	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES2134_112430	COG5322	oxidoreductase activity
NIES2134_112440	COG0825	malonyl-CoA metabolic process
NIES2134_112450	COG1028	Short-chain dehydrogenase reductase Sdr
NIES2134_112460	COG0302	gtp cyclohydrolase
NIES2134_112510	COG0517	IMP dehydrogenase activity
NIES2134_112510	COG1994	Peptidase M50
NIES2134_112530	COG0335	large ribosomal subunit rRNA binding
NIES2134_112540	COG0424	maF-like protein
NIES2134_112570	COG0508	dehydrogenase complex catalyzes the overall conversion of
NIES2134_112580	COG1122	ATPase activity
NIES2134_112600	COG0028	Belongs to the TPP enzyme family
NIES2134_112610	COG0511	ligase activity, forming carbon-carbon bonds
NIES2134_112620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NIES2134_112630	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NIES2134_112650	COG1070	Carbohydrate kinase
NIES2134_112660	COG1160	GTP binding
NIES2134_112690	COG0649	NAD binding
NIES2134_112700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES2134_112720	COG2010	Cytochrome c
NIES2134_112730	COG2010	Cytochrome c
NIES2134_112750	COG5002	protein histidine kinase activity
NIES2134_112750	COG0784	Response regulator, receiver
NIES2134_112750	COG2205	protein histidine kinase activity
NIES2134_112760	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NIES2134_112780	COG0360	Binds together with S18 to 16S ribosomal RNA
NIES2134_112790	COG0179	Fumarylacetoacetate (FAA) hydrolase
NIES2134_112810	COG1494	fructose-1,6-bisphosphatase
NIES2134_112820	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NIES2134_112840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
NIES2134_112880	COG3631	Ketosteroid isomerase-related protein
NIES2134_112910	COG2062	phosphohistidine phosphatase, SixA
NIES2134_112940	COG0745	RESPONSE REGULATOR receiver
NIES2134_112990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NIES2134_113030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NIES2134_113050	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NIES2134_113100	COG1441	menaquinone biosynthetic process
NIES2134_113140	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NIES2134_113160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NIES2134_113160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NIES2134_113170	COG0339	signal peptide processing
NIES2134_113180	COG0739	heme binding
NIES2134_113190	COG0768	penicillin binding
NIES2134_113210	COG0107	imidazoleglycerol-phosphate synthase activity
NIES2134_113220	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
NIES2134_113240	COG0084	hydrolase, TatD family'
NIES2134_113250	COG0268	Binds directly to 16S ribosomal RNA
NIES2134_113260	COG1691	(AIR) carboxylase
NIES2134_113280	COG0326	Molecular chaperone. Has ATPase activity
NIES2134_113290	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NIES2134_113300	COG1615	UPF0182 protein
NIES2134_113310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_113320	COG0457	Tetratricopeptide repeat
NIES2134_113350	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_113390	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
NIES2134_113400	COG0297	glycogen (starch) synthase activity
NIES2134_113400	COG0438	transferase activity, transferring glycosyl groups
NIES2134_113430	COG0515	serine threonine protein kinase
NIES2134_113430	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES2134_113450	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NIES2134_113480	COG3706	GGDEF domain
NIES2134_113490	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIES2134_113520	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NIES2134_113530	COG5002	protein histidine kinase activity
NIES2134_113540	COG1799	cell septum assembly
NIES2134_113550	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NIES2134_113570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NIES2134_113580	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NIES2134_113590	COG0318	PFAM AMP-dependent synthetase and ligase
NIES2134_113600	COG0799	negative regulation of ribosome biogenesis
NIES2134_113610	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES2134_113620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES2134_113660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES2134_113670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIES2134_113690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NIES2134_113730	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
NIES2134_113740	COG0066	3-isopropylmalate dehydratase activity
NIES2134_113770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NIES2134_113790	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NIES2134_113810	COG1606	tRNA processing
NIES2134_113830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NIES2134_113830	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NIES2134_113840	COG3659	wide pore channel activity
NIES2134_113940	COG0842	Transport permease protein
NIES2134_113940	COG1716	ATPase activity
NIES2134_113940	COG1131	(ABC) transporter
NIES2134_113980	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NIES2134_114010	COG0601	transmembrane transport
NIES2134_114050	COG1850	ribulose-bisphosphate carboxylase activity
NIES2134_114080	COG0525	valine-tRNA ligase activity
NIES2134_114090	COG1028	Short-chain dehydrogenase reductase Sdr
NIES2134_114130	COG2319	Wd-40 repeat
NIES2134_114130	COG1672	PFAM Archaeal ATPase
NIES2134_114150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NIES2134_114190	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NIES2134_114210	COG0629	single-stranded DNA binding
NIES2134_114250	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
NIES2134_114280	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NIES2134_114290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIES2134_114340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIES2134_114350	COG2211	Major facilitator Superfamily
NIES2134_114360	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NIES2134_114380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NIES2134_114390	COG0457	Tetratricopeptide repeat
NIES2134_114400	COG0589	response to stress
NIES2134_114470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NIES2134_114480	COG0114	fumarate hydratase activity
NIES2134_114510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NIES2134_114540	COG0564	pseudouridine synthase activity
NIES2134_114550	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES2134_114560	COG1357	PFAM Pentapeptide repeats (8 copies)
NIES2134_114560	COG0515	serine threonine protein kinase
NIES2134_114620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NIES2134_114630	COG0138	bifunctional purine biosynthesis protein purh
NIES2134_114680	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NIES2134_114690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NIES2134_114720	COG0714	Associated with various cellular activities
NIES2134_114730	COG0196	riboflavin kinase activity
NIES2134_114750	COG0540	Belongs to the ATCase OTCase family
NIES2134_114770	COG1562	ergosterol biosynthetic process
NIES2134_114780	COG3349	Catalyzes the conversion of zeta-carotene to lycopene via the intermediary of neurosporene. It carries out two consecutive desaturations (introduction of double bonds) at positions C-7 and C-7'
NIES2134_114780	COG0493	'glutamate synthase
NIES2134_114810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIES2134_114830	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NIES2134_114850	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES2134_114860	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
NIES2134_114880	COG1137	ATPase activity
NIES2134_114940	COG0762	integral membrane protein
NIES2134_114980	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
NIES2134_115020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NIES2134_115040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NIES2134_115060	COG0277	FAD linked oxidase domain protein
NIES2134_115090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES2134_115090	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
NIES2134_115110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NIES2134_115120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES2134_115140	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NIES2134_115150	COG0037	tRNA processing
NIES2134_115160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NIES2134_115180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NIES2134_115190	COG5001	Diguanylate cyclase
NIES2134_115200	COG0336	Belongs to the RNA methyltransferase TrmD family
NIES2134_115240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NIES2134_115250	COG0793	Belongs to the peptidase S41A family
NIES2134_115260	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NIES2134_115280	COG2226	methyltransferase
NIES2134_115290	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIES2134_115290	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NIES2134_115300	COG1271	oxidase subunit
NIES2134_115310	COG1294	oxidase, subunit
NIES2134_115320	COG0473	3-isopropylmalate dehydrogenase activity
NIES2134_115350	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
NIES2134_115360	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
NIES2134_115380	COG0515	serine threonine protein kinase
NIES2134_115410	COG0438	transferase activity, transferring glycosyl groups
NIES2134_115420	COG0438	transferase activity, transferring glycosyl groups
NIES2134_115440	COG0174	glutamine synthetase
NIES2134_115450	COG0012	GTP binding
NIES2134_115460	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NIES2134_115470	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NIES2134_115490	COG0772	Belongs to the SEDS family
NIES2134_115520	COG1218	3'(2'),5'-bisphosphate nucleotidase
NIES2134_115530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NIES2134_115550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NIES2134_115560	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NIES2134_115570	COG0750	zinc metalloprotease
NIES2134_115580	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NIES2134_115610	COG0181	hydroxymethylbilane synthase activity
NIES2134_115710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NIES2134_115720	COG0483	inositol monophosphate 1-phosphatase activity
NIES2134_115740	COG5002	protein histidine kinase activity
NIES2134_115760	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES2134_115790	COG0247	lactate metabolic process
NIES2134_115800	COG0277	FAD linked oxidase domain protein
NIES2134_115810	COG3706	GGDEF domain
NIES2134_115810	COG0745	RESPONSE REGULATOR receiver
NIES2134_115830	COG0815	Transfers the fatty acyl group on membrane lipoproteins
NIES2134_115870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NIES2134_115880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NIES2134_115920	COG0242	peptide deformylase activity
NIES2134_115940	COG0509	glycine decarboxylation via glycine cleavage system
NIES2134_115950	COG0559	Belongs to the binding-protein-dependent transport system permease family
NIES2134_115960	COG0248	Ppx GppA phosphatase
NIES2134_115980	COG0454	-acetyltransferase
NIES2134_115990	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIES2134_116000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NIES2134_116030	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NIES2134_116040	COG0052	Belongs to the universal ribosomal protein uS2 family
NIES2134_116050	COG1192	Involved in chromosome partitioning
NIES2134_116060	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
NIES2134_116100	COG1842	Phage shock protein A
NIES2134_116110	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NIES2134_116130	COG4447	cellulose binding
NIES2134_116150	COG1489	DNA binding
NIES2134_116220	COG0357	Ribosomal RNA small subunit methyltransferase G
NIES2134_116240	COG3659	wide pore channel activity
NIES2134_116250	COG2003	Belongs to the UPF0758 family
NIES2134_116260	COG2326	polyphosphate kinase activity
NIES2134_116280	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NIES2134_116300	COG1178	ABC-type Fe3 transport system permease component
NIES2134_116310	COG0157	Belongs to the NadC ModD family
NIES2134_116320	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NIES2134_116340	COG1492	cobalamin metabolic process
NIES2134_116390	COG5398	heme oxygenase
NIES2134_116400	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NIES2134_116440	COG2226	methyltransferase
NIES2134_116450	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIES2134_116450	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NIES2134_116490	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NIES2134_116500	COG0443	Heat shock 70 kDa protein
NIES2134_116530	COG3264	Mechanosensitive ion channel
NIES2134_116530	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
NIES2134_116540	COG0792	nuclease activity
NIES2134_116550	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NIES2134_116600	COG1528	Iron-storage protein
NIES2134_116620	COG3977	Valine--pyruvate aminotransferase
NIES2134_116630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NIES2134_116650	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NIES2134_116660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NIES2134_116670	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NIES2134_116680	COG0049	tRNA binding
NIES2134_116690	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NIES2134_116700	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NIES2134_116710	COG0051	transcription antitermination factor activity, RNA binding
NIES2134_116730	COG0322	excinuclease ABC activity
NIES2134_116750	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NIES2134_116760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES2134_116770	COG3842	ATPase activity
NIES2134_116780	COG0142	geranyltranstransferase activity
NIES2134_116790	COG1316	TRANSCRIPTIONal
NIES2134_116800	COG0740	serine-type endopeptidase activity
NIES2134_116820	COG0019	diaminopimelate decarboxylase activity
NIES2134_116840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NIES2134_116850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NIES2134_116860	COG0083	homoserine kinase activity
NIES2134_116900	COG1136	(ABC) transporter
NIES2134_116930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NIES2134_116950	COG0860	N-Acetylmuramoyl-L-alanine amidase
NIES2134_116990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NIES2134_117070	COG4372	Transposase
NIES2134_117090	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
NIES2134_117130	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
NIES2134_117140	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NIES2134_117160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NIES2134_117180	COG1215	transferase activity, transferring glycosyl groups
NIES2134_117190	COG1215	transferase activity, transferring glycosyl groups
NIES2134_117210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NIES2134_117230	COG4636	protein conserved in cyanobacteria
NIES2134_117250	COG2843	Capsule synthesis protein
NIES2134_117260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NIES2134_117260	COG0517	IMP dehydrogenase activity
NIES2134_117280	COG0616	signal peptide processing
NIES2134_117310	COG1166	arginine decarboxylase activity
NIES2134_117320	COG0439	Biotin carboxylase
NIES2134_117330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIES2134_117340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NIES2134_117350	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NIES2134_117420	COG0651	ATP synthesis coupled electron transport
NIES2134_117440	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_117470	COG0681	Belongs to the peptidase S26 family
NIES2134_117500	COG2154	pterin-4-alpha-carbinolamine dehydratase
NIES2134_117510	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NIES2134_117520	COG0215	cysteine-tRNA ligase activity
NIES2134_117530	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NIES2134_117540	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NIES2134_117560	COG5001	Diguanylate cyclase
NIES2134_117560	COG1716	ATPase activity
NIES2134_117570	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES2134_117580	COG0527	aspartate kinase activity
NIES2134_117590	COG0697	spore germination
NIES2134_117610	COG2890	protein-(glutamine-N5) methyltransferase activity
NIES2134_117650	COG0151	Belongs to the GarS family
NIES2134_117670	COG1136	(ABC) transporter
NIES2134_117680	COG0003	Pfam Anion-transporting ATPase
NIES2134_117710	COG1035	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus
NIES2134_117730	COG1797	cobyrinic acid a,c-diamide synthase activity
NIES2134_117740	COG0739	heme binding
NIES2134_117760	COG0653	protein targeting
NIES2134_117800	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES2134_117860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NIES2134_117910	COG1982	Orn Lys Arg decarboxylase major
NIES2134_117920	COG3906	Belongs to the UPF0473 family
NIES2134_117950	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NIES2134_117960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NIES2134_117970	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NIES2134_117980	COG0557	exoribonuclease II activity
NIES2134_117990	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NIES2134_118010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES2134_118060	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NIES2134_118060	COG1754	DNA topoisomerase type I activity
NIES2134_118080	COG1126	abc transporter atp-binding protein
NIES2134_118090	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
NIES2134_118150	COG0789	Transcriptional regulator
NIES2134_118170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NIES2134_118190	COG4221	oxidoreductase activity
NIES2134_118210	COG0109	protoheme IX farnesyltransferase activity
NIES2134_118220	COG1612	heme a metabolic process
NIES2134_118260	COG0124	histidyl-tRNA synthetase
NIES2134_118280	COG0497	DNA recombination
NIES2134_118300	COG1131	(ABC) transporter
NIES2134_118330	COG0396	ATPase activity
NIES2134_118340	COG0719	Fe-S assembly protein
NIES2134_118360	COG3128	pkhd-type hydroxylase
NIES2134_118380	COG5002	protein histidine kinase activity
NIES2134_118400	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NIES2134_118420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
NIES2134_118440	COG0572	uridine kinase
NIES2134_118450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
NIES2134_118500	COG2217	Heavy metal translocating P-type atpase
NIES2134_118540	COG0730	response to heat
NIES2134_118550	COG0492	ferredoxin-NADP+ reductase activity
NIES2134_118560	COG1196	nuclear chromosome segregation
NIES2134_118580	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NIES2134_118590	COG0800	Aldolase
NIES2134_118650	COG0195	Participates in both transcription termination and antitermination
NIES2134_118660	COG0779	Required for maturation of 30S ribosomal subunits
NIES2134_118740	COG0352	thiamine-phosphate diphosphorylase activity
NIES2134_118750	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES2134_118760	COG0354	folic acid binding
NIES2134_118780	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NIES2134_118800	COG2226	methyltransferase
NIES2134_118830	COG1573	uracil-dna glycosylase
NIES2134_118860	COG0237	dephospho-CoA kinase activity
NIES2134_118870	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NIES2134_118880	COG1413	lyase activity
NIES2134_118890	COG1413	lyase activity
NIES2134_118900	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES2134_118910	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NIES2134_118920	COG0237	dephospho-CoA kinase activity
NIES2134_118950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NIES2134_118960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NIES2134_118960	COG0519	Catalyzes the synthesis of GMP from XMP
NIES2134_118970	COG0525	valine-tRNA ligase activity
NIES2134_118980	COG2308	Evidence 4 Homologs of previously reported genes of
NIES2134_119000	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NIES2134_119010	COG1543	Belongs to the glycosyl hydrolase 57 family
NIES2134_119040	COG0033	Phosphoglucomutase
NIES2134_119050	COG0420	3'-5' exonuclease activity
NIES2134_119090	COG1234	tRNA 3'-trailer cleavage
NIES2134_119110	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NIES2134_119120	COG0004	ammonium transporteR
NIES2134_119140	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NIES2134_119160	COG2205	protein histidine kinase activity
NIES2134_119180	COG1126	abc transporter atp-binding protein
NIES2134_119210	COG1872	DUF167
NIES2134_119230	COG0180	Tryptophanyl-tRNA synthetase
NIES2134_119270	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES2134_119280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NIES2134_119290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NIES2134_119290	COG1116	anion transmembrane transporter activity
NIES2134_119300	COG1116	anion transmembrane transporter activity
NIES2134_119410	COG0515	serine threonine protein kinase
NIES2134_119430	COG0850	regulation of cytokinetic process
NIES2134_119440	COG2894	cell division
NIES2134_119450	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
NIES2134_119470	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NIES2134_119530	COG0857	belongs to the CobB CobQ family
NIES2134_119560	COG0598	Magnesium transport protein CorA
NIES2134_119580	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES2134_119590	COG2045	Belongs to the ComB family
NIES2134_119610	COG0681	Belongs to the peptidase S26 family
NIES2134_119670	COG0569	domain protein
NIES2134_119700	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NIES2134_119710	COG1012	belongs to the aldehyde dehydrogenase family
NIES2134_119730	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NIES2134_119730	COG0438	transferase activity, transferring glycosyl groups
NIES2134_119760	COG0431	NADPH-dependent FMN reductase
NIES2134_119770	COG0113	porphobilinogen synthase activity
NIES2134_119790	COG0024	Methionine aminopeptidase
NIES2134_119800	COG0415	Belongs to the DNA photolyase family
NIES2134_119820	COG1366	Belongs to the anti-sigma-factor antagonist family
NIES2134_119830	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NIES2134_119850	COG0356	it plays a direct role in the translocation of protons across the membrane
NIES2134_119860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIES2134_119880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NIES2134_119890	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NIES2134_119900	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NIES2134_119910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NIES2134_119920	COG5002	protein histidine kinase activity
NIES2134_119940	COG0159	tryptophan synthase activity
NIES2134_119950	COG0772	Belongs to the SEDS family
NIES2134_119960	COG4172	Belongs to the ABC transporter superfamily
NIES2134_119980	COG0515	serine threonine protein kinase
NIES2134_119990	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES2134_120020	COG0475	glutathione-regulated potassium exporter activity
NIES2134_120030	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NIES2134_120040	COG0802	atpase or kinase
NIES2134_120050	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES2134_120060	COG2177	Part of the ABC transporter FtsEX involved in
NIES2134_120070	COG2884	Cell division ATP-binding protein ftsE
NIES2134_120110	COG1943	Transposase
NIES2134_120160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NIES2134_120170	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NIES2134_120190	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NIES2134_120200	COG0316	Belongs to the HesB IscA family
NIES2134_120210	COG1090	epimerase
NIES2134_120230	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NIES2134_120250	COG1943	Transposase
NIES2134_120280	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NIES2134_120300	COG0077	Prephenate dehydratase
NIES2134_120310	COG0686	Belongs to the AlaDH PNT family
NIES2134_120320	COG0575	Belongs to the CDS family
NIES2134_120330	COG1595	DNA-templated transcription, initiation
NIES2134_120350	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NIES2134_120380	COG0411	ABC transporter
NIES2134_120400	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
NIES2134_120420	COG1725	Transcriptional regulator
NIES2134_120430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NIES2134_120440	COG0483	inositol monophosphate 1-phosphatase activity
NIES2134_120480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES2134_120490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_120510	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NIES2134_120520	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NIES2134_120530	COG1058	Belongs to the CinA family
NIES2134_120530	COG1546	Belongs to the CinA family
NIES2134_120570	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
NIES2134_120670	COG3937	granule-associated protein
NIES2134_120680	COG0659	secondary active sulfate transmembrane transporter activity
NIES2134_120700	COG2094	Belongs to the DNA glycosylase MPG family
NIES2134_120720	COG0484	heat shock protein binding
NIES2134_120730	COG0443	Heat shock 70 kDa protein
NIES2134_120750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES2134_120750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NIES2134_120770	COG0739	heme binding
NIES2134_120780	COG1587	Uroporphyrinogen-III synthase
NIES2134_120800	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NIES2134_120810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NIES2134_120820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NIES2134_120840	COG2302	S4 RNA-binding domain
NIES2134_120870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NIES2134_120880	COG0573	inorganic phosphate transmembrane transporter activity
NIES2134_120890	COG0573	inorganic phosphate transmembrane transporter activity
NIES2134_120900	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NIES2134_120970	COG1943	Transposase
NIES2134_120980	COG0419	ATPase involved in DNA repair
NIES2134_120990	COG2304	oxidoreductase activity
NIES2134_121010	COG1028	Short-chain dehydrogenase reductase Sdr
NIES2134_121040	COG0546	phosphoglycolate phosphatase activity
NIES2134_121040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
NIES2134_121050	COG0330	HflC and HflK could
NIES2134_121060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NIES2134_121080	COG0047	phosphoribosylformylglycinamidine synthase activity
NIES2134_121090	COG2095	MarC family integral membrane protein
NIES2134_121100	COG0741	lytic transglycosylase activity
NIES2134_121100	COG0791	NLP P60 protein
NIES2134_121110	COG0516	GMP reductase activity
NIES2134_121130	COG0751	glycine-tRNA ligase activity
NIES2134_121140	COG1185	polyribonucleotide nucleotidyltransferase activity
NIES2134_121190	COG1575	Belongs to the MenA family. Type 1 subfamily
NIES2134_121210	COG0456	acetyltransferase
NIES2134_121220	COG0778	Nitroreductase
NIES2134_121230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NIES2134_121240	COG0745	RESPONSE REGULATOR receiver
NIES2134_121250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NIES2134_121260	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
NIES2134_121270	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NIES2134_121300	COG3781	membrane
NIES2134_121310	COG2217	Heavy metal translocating P-type atpase
NIES2134_121330	COG1943	Transposase
NIES2134_121370	COG0443	Heat shock 70 kDa protein
NIES2134_121380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NIES2134_121410	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NIES2134_121440	COG0515	serine threonine protein kinase
NIES2134_121440	COG2815	serine threonine protein kinase
NIES2134_121470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NIES2134_121480	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
NIES2134_121510	COG0732	type I restriction modification DNA specificity domain
NIES2134_121540	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
NIES2134_121570	COG1381	Involved in DNA repair and RecF pathway recombination
NIES2134_121590	COG2208	phosphoserine phosphatase activity
NIES2134_121600	COG1943	Transposase
NIES2134_121630	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NIES2134_121650	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES2134_121660	COG0631	protein serine/threonine phosphatase activity
NIES2134_121680	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
NIES2134_121780	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NIES2134_121790	COG2255	four-way junction helicase activity
NIES2134_121800	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NIES2134_121810	COG0724	RNA recognition motif
NIES2134_121820	COG0482	sulfurtransferase activity
NIES2134_121850	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NIES2134_121860	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
NIES2134_121870	COG0450	alkyl hydroperoxide reductase
NIES2134_121890	COG0628	permease
NIES2134_121910	COG0006	proline dipeptidase activity
NIES2134_121920	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NIES2134_121930	COG0776	regulation of translation
NIES2134_121940	COG0126	phosphoglycerate kinase activity
NIES2134_121950	COG0589	response to stress
NIES2134_121980	COG0135	phosphoribosylanthranilate isomerase activity
NIES2134_122010	COG0469	pyruvate kinase activity
NIES2134_122020	COG0523	cobalamin synthesis protein
NIES2134_122100	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
NIES2134_122110	COG3118	belongs to the thioredoxin family
NIES2134_122120	COG4399	Belongs to the UPF0754 family
NIES2134_122140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NIES2134_122150	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NIES2134_122160	COG5505	Protein of unknown function (DUF819)
NIES2134_122190	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NIES2134_122210	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
NIES2134_122300	COG4279	zinc finger
NIES2134_122310	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
NIES2134_122340	COG1657	PFAM Prenyltransferase squalene oxidase
NIES2134_122350	COG4783	chaperone-mediated protein folding
NIES2134_122380	COG0529	Catalyzes the synthesis of activated sulfate
NIES2134_122400	COG0110	maltose O-acetyltransferase activity
NIES2134_122480	COG1216	Glycosyl transferase, family 2
NIES2134_122490	COG1215	transferase activity, transferring glycosyl groups
NIES2134_122520	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NIES2134_122530	COG1943	Transposase
NIES2134_122550	COG0556	nucleotide-excision repair
NIES2134_122570	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NIES2134_122590	COG0583	DNA-binding transcription factor activity
NIES2134_122610	COG0170	dolichyl monophosphate biosynthetic process
NIES2134_122620	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NIES2134_122670	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
NIES2134_122680	COG0539	negative regulation of cytoplasmic translation
NIES2134_122690	COG1970	mechanosensitive ion channel activity
NIES2134_122710	COG3158	transport of potassium into the cell
NIES2134_122720	COG0436	Aminotransferase
NIES2134_122730	COG0371	Dehydrogenase
NIES2134_122750	COG2022	thiamine diphosphate biosynthetic process
NIES2134_122750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NIES2134_122770	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NIES2134_122780	COG0587	DNA-directed DNA polymerase activity
NIES2134_122820	COG0267	Belongs to the bacterial ribosomal protein bL33 family
NIES2134_122830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NIES2134_122840	COG3443	Belongs to the bacterial solute-binding protein 9 family
NIES2134_122840	COG0803	Belongs to the bacterial solute-binding protein 9 family
NIES2134_122850	COG1121	(ABC) transporter
NIES2134_122880	COG0596	Alpha beta hydrolase
NIES2134_122900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIES2134_122910	COG0587	DNA-directed DNA polymerase activity
NIES2134_122960	COG0275	rRNA processing
NIES2134_123020	COG3932	Exopolysaccharide synthesis, ExoD
NIES2134_123040	COG0058	SHG alpha-glucan phosphorylase activity
NIES2134_123060	COG0714	Associated with various cellular activities
NIES2134_123120	COG3118	belongs to the thioredoxin family
NIES2134_123140	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NIES2134_123180	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NIES2134_123190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_123230	COG0495	leucyl-tRNA aminoacylation
NIES2134_123290	COG1331	Highly conserved protein containing a thioredoxin domain
NIES2134_123300	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NIES2134_123340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NIES2134_123350	COG3854	ATPases associated with a variety of cellular activities
NIES2134_123370	COG1191	sigma factor activity
NIES2134_123380	COG1968	undecaprenyl-diphosphatase activity
NIES2134_123400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NIES2134_123410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES2134_123420	COG0668	transmembrane transport
NIES2134_123450	COG0251	oxidation-reduction process
NIES2134_123510	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NIES2134_123530	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NIES2134_123540	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_123560	COG0166	Belongs to the GPI family
NIES2134_123580	COG0617	tRNA 3'-terminal CCA addition
NIES2134_123610	COG0137	argininosuccinate synthase activity
NIES2134_123620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NIES2134_123650	COG1640	4-alpha-glucanotransferase
NIES2134_123680	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
NIES2134_123690	COG1446	asparaginase
NIES2134_123720	COG3046	protein related to deoxyribodipyrimidine photolyase
NIES2134_123730	COG0134	indole-3-glycerol-phosphate synthase activity
NIES2134_123740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NIES2134_123750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
NIES2134_123760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NIES2134_123770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
NIES2134_123790	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NIES2134_123800	COG1132	(ABC) transporter
NIES2134_123810	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NIES2134_123820	COG0644	oxidoreductase
NIES2134_123840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NIES2134_123850	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NIES2134_123870	COG0038	chloride channel
NIES2134_123880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NIES2134_123890	COG0009	L-threonylcarbamoyladenylate synthase
NIES2134_123900	COG4243	Vitamin k epoxide reductase
NIES2134_123910	COG1672	PFAM Archaeal ATPase
NIES2134_123920	COG2814	Major facilitator Superfamily
NIES2134_123950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NIES2134_123990	COG0131	Imidazoleglycerol-phosphate dehydratase
NIES2134_124000	COG0484	heat shock protein binding
NIES2134_124010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES2134_124030	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NIES2134_124050	COG0419	ATPase involved in DNA repair
NIES2134_124120	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NIES2134_124150	COG0484	heat shock protein binding
NIES2134_124180	COG1104	cysteine desulfurase activity
NIES2134_124200	COG4802	Ferredoxin thioredoxin reductase catalytic beta chain
NIES2134_124220	COG2957	Belongs to the agmatine deiminase family
NIES2134_124230	COG0254	rRNA binding
NIES2134_124240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NIES2134_124250	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NIES2134_124260	COG0101	tRNA pseudouridine synthase activity
NIES2134_124270	COG0203	ribosomal protein L17
NIES2134_124280	COG0202	RNA polymerase activity
NIES2134_124290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NIES2134_124300	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NIES2134_124310	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
NIES2134_124320	COG0563	adenylate kinase activity
NIES2134_124330	COG0201	protein transport
NIES2134_124340	COG0200	Binds to the 23S rRNA
NIES2134_124350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NIES2134_124360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NIES2134_124370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NIES2134_124380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NIES2134_124390	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NIES2134_124400	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
NIES2134_124410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NIES2134_124420	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NIES2134_124430	COG0255	Belongs to the universal ribosomal protein uL29 family
NIES2134_124440	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NIES2134_124450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NIES2134_124460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
NIES2134_124470	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
NIES2134_124480	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NIES2134_124490	COG0089	rRNA binding
NIES2134_124500	COG0088	Forms part of the polypeptide exit tunnel
NIES2134_124510	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NIES2134_124520	COG0343	queuine tRNA-ribosyltransferase activity
NIES2134_124560	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NIES2134_124590	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NIES2134_124600	COG0628	permease
NIES2134_124630	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NIES2134_124640	COG1940	carbohydrate kinase activity
NIES2134_124650	COG1316	TRANSCRIPTIONal
NIES2134_124660	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NIES2134_124680	COG5002	protein histidine kinase activity
NIES2134_124690	COG0728	peptidoglycan biosynthetic process
NIES2134_124700	COG0592	DNA-directed DNA polymerase activity
NIES2134_124730	COG1348	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex which has 2 components the iron protein and the molybdenum-iron protein
NIES2134_124750	COG2710	Component of the dark-operative protochlorophyllide reductase (DPOR) that uses Mg-ATP and reduced ferredoxin to reduce ring D of protochlorophyllide (Pchlide) to form chlorophyllide a (Chlide). This reaction is light-independent. The NB-protein
NIES2134_124800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NIES2134_124820	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NIES2134_124830	COG2252	PERMEase
NIES2134_124880	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NIES2134_124890	COG2052	Domain of unknown function (DUF370)
NIES2134_124900	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NIES2134_124910	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NIES2134_124930	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NIES2134_124940	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NIES2134_124950	COG0793	Belongs to the peptidase S41A family
NIES2134_124960	COG3659	wide pore channel activity
NIES2134_124970	COG2197	response regulator
NIES2134_125030	COG0284	orotidine-5'-phosphate decarboxylase activity
NIES2134_125060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NIES2134_125080	COG2385	sporulation resulting in formation of a cellular spore
NIES2134_125100	COG0233	cytoplasmic translational termination
NIES2134_125110	COG0528	UMP kinase activity
NIES2134_125130	COG0745	RESPONSE REGULATOR receiver
NIES2134_125150	COG0542	response to heat
NIES2134_125250	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NIES2134_125260	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
NIES2134_125280	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
NIES2134_125300	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NIES2134_125310	COG3536	Protein conserved in bacteria
NIES2134_125350	COG1193	negative regulation of DNA recombination
NIES2134_125360	COG0017	Asparaginyl-tRNA synthetase
NIES2134_125370	COG0589	response to stress
NIES2134_125370	COG0475	glutathione-regulated potassium exporter activity
NIES2134_125380	COG0133	tryptophan synthase activity
NIES2134_125400	COG0131	Imidazoleglycerol-phosphate dehydratase