locus-tag	class	description
TM_0006	COG4948	Mandelate Racemase Muconate Lactonizing
TM_0008	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TM_0014	COG0840	transmembrane signaling receptor activity
TM_0015	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TM_0016	COG1144	Oxidoreductase
TM_0017	COG0674	pyruvate-flavodoxin oxidoreductase activity
TM_0018	COG1013	pyruvate-flavodoxin oxidoreductase activity
TM_0019	COG1028	Short-chain dehydrogenase reductase Sdr
TM_0020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TM_0021	COG1993	acr, cog1993
TM_0022	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TM_0023	COG0840	transmembrane signaling receptor activity
TM_0027	COG4608	Belongs to the ABC transporter superfamily
TM_0028	COG0444	Belongs to the ABC transporter superfamily
TM_0030	COG0601	transmembrane transport
TM_0031	COG4166	transmembrane transport
TM_0036	COG1618	nucleotide phosphatase activity, acting on free nucleotides
TM_0037	COG2199	diguanylate cyclase activity
TM_0037	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TM_0038	COG0720	synthase
TM_0039	COG1469	GTP cyclohydrolase I activity
TM_0040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TM_0041	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TM_0041	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TM_0042	COG0006	proline dipeptidase activity
TM_0043	COG1132	(ABC) transporter
TM_0047	COG0675	Transposase, IS605 OrfB family
TM_0049	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
TM_0051	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TM_0051	COG1918	ferrous iron import across plasma membrane
TM_0055	COG3661	Belongs to the glycosyl hydrolase 67 family
TM_0056	COG0747	negative chemotaxis
TM_0057	COG4608	Belongs to the ABC transporter superfamily
TM_0058	COG0444	Belongs to the ABC transporter superfamily
TM_0059	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_0060	COG0601	transmembrane transport
TM_0061	COG3693	PFAM glycoside hydrolase, family 10
TM_0064	COG1904	glucuronate isomerase
TM_0065	COG1414	Transcriptional regulator
TM_0066	COG0800	Aldolase
TM_0068	COG0246	Mannitol dehydrogenase
TM_0069	COG1312	Catalyzes the dehydration of D-mannonate
TM_0072	COG0601	transmembrane transport
TM_0073	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_0074	COG0444	Belongs to the ABC transporter superfamily
TM_0075	COG4608	Belongs to the ABC transporter superfamily
TM_0077	COG3458	cephalosporin-C deacetylase activity
TM_0078	COG1120	ATPase activity
TM_0079	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TM_0080	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TM_0081	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
TM_0082	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TM_0086	COG0728	peptidoglycan biosynthetic process
TM_0087	COG1355	regulation of microtubule-based process
TM_0095	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
TM_0096	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TM_0096	COG3116	cell division
TM_0097	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TM_0098	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TM_0100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TM_0108	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TM_0110	COG1940	carbohydrate kinase activity
TM_0112	COG1172	Belongs to the binding-protein-dependent transport system permease family
TM_0115	COG1129	ABC transporter
TM_0116	COG1070	Carbohydrate kinase
TM_0120	COG0778	Nitroreductase
TM_0121	COG1509	lysine 2,3-aminomutase activity
TM_0123	COG0803	Belongs to the bacterial solute-binding protein 9 family
TM_0124	COG1121	(ABC) transporter
TM_0125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TM_0126	COG0745	RESPONSE REGULATOR receiver
TM_0132	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
TM_0133	COG1335	isochorismatase
TM_0134	COG0492	ferredoxin-NADP+ reductase activity
TM_0136	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TM_0137	COG0159	tryptophan synthase activity
TM_0138	COG0133	tryptophan synthase activity
TM_0139	COG0135	phosphoribosylanthranilate isomerase activity
TM_0140	COG0134	indole-3-glycerol-phosphate synthase activity
TM_0141	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TM_0141	COG0512	Glutamine amidotransferase of anthranilate synthase
TM_0142	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TM_0143	COG0745	RESPONSE REGULATOR receiver
TM_0143	COG3706	GGDEF domain
TM_0145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TM_0146	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TM_0147	COG0799	negative regulation of ribosome biogenesis
TM_0148	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TM_0149	COG0416	fatty acid biosynthetic process
TM_0150	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TM_0156	COG1785	Belongs to the alkaline phosphatase family
TM_0158	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TM_0159	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TM_0165	COG0632	four-way junction helicase activity
TM_0166	COG0285	dihydrofolate synthase activity
TM_0167	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TM_0168	COG0495	leucyl-tRNA aminoacylation
TM_0169	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TM_0171	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TM_0172	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TM_0173	COG1110	DNA topoisomerase II activity
TM_0174	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TM_0175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TM_0177	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
TM_0178	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TM_0182	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM_0183	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TM_0183	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TM_0184	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TM_0190	COG4139	cobalamin transport
TM_0191	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TM_0192	COG2359	stage V sporulation protein S
TM_0193	COG0390	transport system, permease component
TM_0194	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TM_0195	COG0248	Ppx GppA phosphatase
TM_0197	COG0037	tRNA processing
TM_0198	COG0542	response to heat
TM_0199	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TM_0200	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
TM_0205	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TM_0207	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TM_0208	COG0469	pyruvate kinase activity
TM_0209	COG0205	6-phosphofructokinase activity
TM_0211	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TM_0212	COG0509	glycine decarboxylation via glycine cleavage system
TM_0213	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TM_0214	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TM_0216	COG0752	glycyl-tRNA synthetase alpha subunit
TM_0217	COG0751	glycine-tRNA ligase activity
TM_0218	COG1157	protein secretion by the type III secretion system
TM_0220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TM_0221	COG1766	The M ring may be actively involved in energy transduction
TM_0222	COG1122	ATPase activity
TM_0224	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TM_0224	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TM_0225	COG2515	1-aminocyclopropane-1-carboxylate deaminase
TM_0231	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TM_0232	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TM_0233	COG0772	Belongs to the SEDS family
TM_0234	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TM_0235	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TM_0236	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TM_0237	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TM_0239	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TM_0240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TM_0243	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TM_0244	COG4656	Part of a membrane complex involved in electron transport
TM_0245	COG4658	electron transport chain
TM_0247	COG4660	Part of a membrane complex involved in electron transport
TM_0249	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
TM_0249	COG2878	Part of a membrane complex involved in electron transport
TM_0250	COG0758	DNA mediated transformation
TM_0251	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
TM_0252	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TM_0253	COG0792	nuclease activity
TM_0255	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TM_0258	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TM_0259	COG1181	Belongs to the D-alanine--D-alanine ligase family
TM_0261	COG0306	phosphate transporter
TM_0262	COG0592	DNA-directed DNA polymerase activity
TM_0263	COG0445	tRNA wobble uridine modification
TM_0264	COG1187	pseudouridine synthase activity
TM_0265	COG0322	excinuclease ABC activity
TM_0266	COG0776	regulation of translation
TM_0267	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TM_0268	COG0646	methionine synthase
TM_0268	COG1410	methionine synthase
TM_0270	COG0646	methionine synthase
TM_0270	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TM_0272	COG0574	Belongs to the PEP-utilizing enzyme family
TM_0272	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TM_0273	COG0191	fructose-bisphosphate aldolase activity
TM_0274	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TM_0276	COG2160	L-arabinose isomerase activity
TM_0278	COG1175	transmembrane transport
TM_0281	COG3534	alpha-L-arabinofuranosidase
TM_0283	COG0235	Class ii aldolase
TM_0285	COG0371	Dehydrogenase
TM_0287	COG1132	(ABC) transporter
TM_0288	COG1132	(ABC) transporter
TM_0289	COG0205	6-phosphofructokinase activity
TM_0290	COG0372	Belongs to the citrate synthase family
TM_0291	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TM_0292	COG0066	3-isopropylmalate dehydratase activity
TM_0293	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TM_0294	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TM_0295	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TM_0296	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TM_0297	COG1028	Short-chain dehydrogenase reductase Sdr
TM_0298	COG1063	alcohol dehydrogenase
TM_0301	COG0601	transmembrane transport
TM_0302	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_0303	COG4608	Belongs to the ABC transporter superfamily
TM_0308	COG1501	Belongs to the glycosyl hydrolase 31 family
TM_0309	COG0747	negative chemotaxis
TM_0312	COG0673	inositol 2-dehydrogenase activity
TM_0313	COG0667	Aldo Keto reductase
TM_0317	COG2217	Heavy metal translocating P-type atpase
TM_0318	COG2226	methyltransferase
TM_0322	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TM_0324	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TM_0325	COG1028	Short-chain dehydrogenase reductase Sdr
TM_0326	COG1737	Transcriptional regulator
TM_0327	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TM_0330	COG1574	metal-dependent hydrolase with the TIM-barrel fold
TM_0331	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TM_0332	COG0284	orotidine-5'-phosphate decarboxylase activity
TM_0333	COG0167	dihydroorotate dehydrogenase activity
TM_0334	COG0543	2 iron, 2 sulfur cluster binding
TM_0335	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TM_0336	COG1073	alpha beta
TM_0337	COG1032	radical SAM domain protein
TM_0343	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TM_0345	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TM_0346	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TM_0347	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TM_0348	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TM_0348	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TM_0349	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TM_0351	COG0577	efflux transmembrane transporter activity
TM_0351	COG1136	(ABC) transporter
TM_0352	COG1136	(ABC) transporter
TM_0353	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TM_0356	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TM_0358	COG1597	lipid kinase activity
TM_0360	COG3956	TIGRFAM MazG family protein
TM_0362	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TM_0364	COG0366	Alpha amylase catalytic
TM_0365	COG1362	aminopeptidase activity
TM_0366	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TM_0370	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
TM_0371	COG1438	arginine binding
TM_0373	COG0443	Heat shock 70 kDa protein
TM_0374	COG0071	Belongs to the small heat shock protein (HSP20) family
TM_0375	COG4869	propanediol catabolic process
TM_0376	COG0730	response to heat
TM_0379	COG0446	pyridine nucleotide-disulphide oxidoreductase
TM_0382	COG1194	a g-specific adenine glycosylase
TM_0383	COG0778	Nitroreductase
TM_0386	COG0778	Nitroreductase
TM_0389	COG1131	(ABC) transporter
TM_0392	COG0438	transferase activity, transferring glycosyl groups
TM_0396	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
TM_0396	COG0493	'glutamate synthase
TM_0397	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TM_0397	COG0069	glutamate synthase activity
TM_0398	COG0067	glutamate synthase
TM_0400	COG3850	Histidine kinase
TM_0400	COG5002	protein histidine kinase activity
TM_0401	COG1435	thymidine kinase activity
TM_0402	COG0004	ammonium transporteR
TM_0403	COG0347	Belongs to the P(II) protein family
TM_0405	COG1013	pyruvate-flavodoxin oxidoreductase activity
TM_0408	COG2201	protein-glutamate methylesterase activity
TM_0409	COG0739	heme binding
TM_0412	COG1063	alcohol dehydrogenase
TM_0413	COG1402	creatininase
TM_0414	COG0673	inositol 2-dehydrogenase activity
TM_0416	COG1082	Xylose isomerase domain protein TIM barrel
TM_0417	COG0672	)-iron permease
TM_0419	COG1175	transmembrane transport
TM_0420	COG3833	ABC-type maltose transport systems, permease component
TM_0421	COG3842	ATPase activity
TM_0423	COG0371	Dehydrogenase
TM_0428	COG1902	pentaerythritol trinitrate reductase activity
TM_0429	COG0840	transmembrane signaling receptor activity
TM_0430	COG0395	ABC-type sugar transport system, permease component
TM_0431	COG1175	transmembrane transport
TM_0433	COG3866	Pectate lyase
TM_0434	COG1486	melibiose metabolic process
TM_0435	COG3458	cephalosporin-C deacetylase activity
TM_0438	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
TM_0439	COG1802	Transcriptional regulator
TM_0441	COG1028	Short-chain dehydrogenase reductase Sdr
TM_0443	COG1070	Carbohydrate kinase
TM_0444	COG1027	Aspartate ammonia-lyase
TM_0446	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TM_0447	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TM_0448	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TM_0449	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TM_0451	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TM_0452	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TM_0453	COG0250	Participates in transcription elongation, termination and antitermination
TM_0454	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TM_0455	COG0081	regulation of translation
TM_0456	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TM_0457	COG0222	ribosome binding
TM_0458	COG0085	RNA polymerase activity
TM_0459	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TM_0460	COG0747	negative chemotaxis
TM_0461	COG0587	DNA-directed DNA polymerase activity
TM_0462	COG0564	pseudouridine synthase activity
TM_0463	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TM_0464	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TM_0466	COG0217	transcriptional regulatory protein
TM_0468	COG0745	RESPONSE REGULATOR receiver
TM_0472	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TM_0473	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TM_0475	COG1335	isochorismatase
TM_0477	COG1196	nuclear chromosome segregation
TM_0478	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TM_0479	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TM_0480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TM_0483	COG1116	anion transmembrane transporter activity
TM_0485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TM_0487	COG2151	metal-sulfur cluster biosynthetic enzyme
TM_0488	COG2890	protein-(glutamine-N5) methyltransferase activity
TM_0490	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TM_0492	COG0180	Tryptophanyl-tRNA synthetase
TM_0493	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TM_0494	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TM_0495	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TM_0498	COG0444	Belongs to the ABC transporter superfamily
TM_0500	COG4608	Belongs to the ABC transporter superfamily
TM_0501	COG0444	Belongs to the ABC transporter superfamily
TM_0502	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_0503	COG0601	transmembrane transport
TM_0505	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TM_0506	COG0459	protein refolding
TM_0508	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TM_0508	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TM_0511	COG1573	uracil-dna glycosylase
TM_0513	COG0606	chelatase, subunit chli
TM_0514	COG0442	prolyl-tRNA aminoacylation
TM_0515	COG1242	4 iron, 4 sulfur cluster binding
TM_0520	COG0482	sulfurtransferase activity
TM_0521	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TM_0522	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TM_0525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TM_0526	COG1923	regulation of RNA biosynthetic process
TM_0527	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TM_0528	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TM_0529	COG2608	mercury ion transmembrane transporter activity
TM_0530	COG4608	Belongs to the ABC transporter superfamily
TM_0531	COG0747	negative chemotaxis
TM_0532	COG0601	transmembrane transport
TM_0533	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_0534	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TM_0537	COG4717	serine-type aminopeptidase activity
TM_0539	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
TM_0541	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TM_0541	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
TM_0544	COG1131	(ABC) transporter
TM_0545	COG0083	homoserine kinase activity
TM_0546	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TM_0547	COG0527	aspartate kinase activity
TM_0548	COG0028	Belongs to the TPP enzyme family
TM_0549	COG0440	acetolactate synthase activity
TM_0550	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TM_0551	COG0129	dihydroxy-acid dehydratase activity
TM_0552	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TM_0553	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TM_0554	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TM_0555	COG0066	3-isopropylmalate dehydratase activity
TM_0556	COG0473	3-isopropylmalate dehydrogenase activity
TM_0557	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TM_0558	COG0505	Belongs to the CarA family
TM_0561	COG0598	Magnesium transport protein CorA
TM_0565	COG1489	DNA binding
TM_0567	COG1959	2 iron, 2 sulfur cluster binding
TM_0570	COG0552	protein localization to endoplasmic reticulum
TM_0571	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TM_0572	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TM_0573	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TM_0574	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TM_0575	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TM_0576	COG2176	DNA-directed DNA polymerase activity
TM_0577	COG0456	acetyltransferase
TM_0578	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TM_0579	COG0037	tRNA processing
TM_0580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TM_0585	COG0673	inositol 2-dehydrogenase activity
TM_0586	COG0697	spore germination
TM_0587	COG0517	IMP dehydrogenase activity
TM_0587	COG1227	inorganic diphosphatase activity
TM_0588	COG1077	Cell shape determining protein MreB Mrl
TM_0590	COG0768	penicillin binding
TM_0594	COG2252	PERMEase
TM_0596	COG1175	transmembrane transport
TM_0598	COG0395	ABC-type sugar transport system, permease component
TM_0603	COG0360	Binds together with S18 to 16S ribosomal RNA
TM_0604	COG0629	single-stranded DNA binding
TM_0605	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TM_0607	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM_0618	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TM_0618	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
TM_0619	COG0297	glycogen (starch) synthase activity
TM_0619	COG0438	transferase activity, transferring glycosyl groups
TM_0622	COG0438	transferase activity, transferring glycosyl groups
TM_0624	COG0438	transferase activity, transferring glycosyl groups
TM_0627	COG0438	transferase activity, transferring glycosyl groups
TM_0630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TM_0632	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TM_0633	COG1705	Flagellar rod assembly protein muramidase FlgJ
TM_0633	COG3951	Flagellar rod assembly protein muramidase FlgJ
TM_0638	COG1596	polysaccharide export
TM_0640	COG1011	Hydrolase
TM_0645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TM_0647	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TM_0651	COG0561	phosphatase activity
TM_0653	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM_0654	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TM_0655	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TM_0656	COG1476	TRANSCRIPTIONal
TM_0657	COG1592	Rubrerythrin
TM_0658	COG2033	superoxide reductase activity
TM_0659	COG1773	rubredoxin
TM_0660	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
TM_0662	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TM_0665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TM_0666	COG1045	serine acetyltransferase
TM_0667	COG0084	hydrolase, TatD family'
TM_0675	COG1582	Flagellar protein (FlbD)
TM_0677	COG1360	Flagellar Motor Protein
TM_0679	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
TM_0686	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TM_0687	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TM_0688	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
TM_0689	COG0126	phosphoglycerate kinase activity
TM_0689	COG0149	triose-phosphate isomerase activity
TM_0692	COG0736	holo-[acyl-carrier-protein] synthase activity
TM_0694	COG0544	peptidyl-prolyl cis-trans isomerase activity
TM_0695	COG0740	serine-type endopeptidase activity
TM_0698	COG1338	Plays a role in the flagellum-specific transport system
TM_0700	COG2201	protein-glutamate methylesterase activity
TM_0701	COG0835	chemotaxis
TM_0702	COG2198	Histidine kinase
TM_0702	COG0643	Histidine kinase
TM_0703	COG1546	Belongs to the CinA family
TM_0703	COG1058	Belongs to the CinA family
TM_0704	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TM_0705	COG1136	(ABC) transporter
TM_0707	COG0357	Ribosomal RNA small subunit methyltransferase G
TM_0708	COG0095	Lipoate-protein ligase
TM_0709	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TM_0716	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TM_0717	COG0511	ligase activity, forming carbon-carbon bonds
TM_0718	COG0835	chemotaxis
TM_0719	COG0215	cysteine-tRNA ligase activity
TM_0720	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TM_0721	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TM_0722	COG0557	exoribonuclease II activity
TM_0726	COG0312	modulator of DNA gyrase
TM_0727	COG0312	modulator of DNA gyrase
TM_0729	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TM_0730	COG1490	D-aminoacyl-tRNA deacylase activity
TM_0731	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TM_0734	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TM_0736	COG1482	cell wall glycoprotein biosynthetic process
TM_0739	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TM_0739	COG2199	diguanylate cyclase activity
TM_0740	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TM_0741	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TM_0742	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
TM_0744	COG0438	transferase activity, transferring glycosyl groups
TM_0747	COG0793	Belongs to the peptidase S41A family
TM_0748	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TM_0751	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TM_0752	COG1486	melibiose metabolic process
TM_0753	COG2226	methyltransferase
TM_0754	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TM_0755	COG0426	domain, Protein
TM_0756	COG1216	Glycosyl transferase, family 2
TM_0756	COG0463	Glycosyl transferase, family 2
TM_0757	COG0463	Glycosyl transferase, family 2
TM_0757	COG0457	Tetratricopeptide repeat
TM_0762	COG0052	Belongs to the universal ribosomal protein uS2 family
TM_0763	COG0393	Putative heavy-metal-binding
TM_0765	COG1131	(ABC) transporter
TM_0767	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
TM_0768	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TM_0769	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TM_0770	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM_0771	COG0470	DNA polymerase III
TM_0772	COG1774	PSP1 C-terminal conserved region
TM_0775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TM_0785	COG1659	Linocin_M18 bacteriocin protein
TM_0787	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TM_0788	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TM_0790	COG0351	phosphomethylpyrimidine kinase
TM_0790	COG1992	Thiamine-phosphate synthase
TM_0791	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TM_0792	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TM_0793	COG1131	(ABC) transporter
TM_0797	COG2045	Belongs to the ComB family
TM_0798	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TM_0799	COG1268	BioY protein
TM_0800	COG2070	2-Nitropropane dioxygenase
TM_0801	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TM_0802	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TM_0803	COG0504	CTP synthase activity
TM_0804	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TM_0805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TM_0807	COG0450	alkyl hydroperoxide reductase
TM_0808	COG1846	Transcriptional regulator
TM_0808	COG1940	carbohydrate kinase activity
TM_0812	COG0395	ABC-type sugar transport system, permease component
TM_0813	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TM_0815	COG0534	Mate efflux family protein
TM_0818	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
TM_0820	COG1979	alcohol dehydrogenase
TM_0821	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TM_0822	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM_0822	COG0072	phenylalanine-tRNA ligase activity
TM_0823	COG1309	transcriptional regulator
TM_0825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TM_0827	COG3842	ATPase activity
TM_0830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM_0831	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TM_0833	COG0187	DNA topoisomerase II activity
TM_0835	COG0849	cell division
TM_0836	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TM_0839	COG0772	Belongs to the SEDS family
TM_0842	COG2201	protein-glutamate methylesterase activity
TM_0844	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TM_0845	COG4535	Mg2 and Co2 transporter CorC
TM_0846	COG0295	cytidine deaminase activity
TM_0847	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TM_0848	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
TM_0849	COG0484	heat shock protein binding
TM_0850	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TM_0851	COG1420	regulation of RNA biosynthetic process
TM_0852	COG0009	L-threonylcarbamoyladenylate synthase
TM_0853	COG5002	protein histidine kinase activity
TM_0854	COG1639	'signal transduction protein
TM_0855	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TM_0856	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TM_0857	COG0196	riboflavin kinase activity
TM_0859	COG1862	Preprotein translocase
TM_0860	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TM_0861	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TM_0863	COG0359	binds to the 23S rRNA
TM_0864	COG1234	tRNA 3'-trailer cleavage
TM_0870	COG0768	penicillin binding
TM_0872	COG0275	rRNA processing
TM_0874	COG1214	PFAM Peptidase M22, glycoprotease
TM_0876	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TM_0877	COG0148	phosphopyruvate hydratase activity
TM_0878	COG0674	pyruvate-flavodoxin oxidoreductase activity
TM_0878	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TM_0880	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
TM_0881	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
TM_0883	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TM_0886	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
TM_0887	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TM_0889	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TM_0890	COG0750	zinc metalloprotease
TM_0891	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TM_0892	COG2239	Acts as a magnesium transporter
TM_0893	COG1968	undecaprenyl-diphosphatase activity
TM_0895	COG0297	glycogen (starch) synthase activity
TM_0896	COG1085	galactose-1-phosphate uridylyltransferase
TM_0897	COG2359	stage V sporulation protein S
TM_0902	COG1191	sigma factor activity
TM_0903	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
TM_0904	COG1776	CheC inhibitor of MCP methylation
TM_0906	COG0455	bacterial-type flagellum organization
TM_0907	COG1419	protein localization to endoplasmic reticulum
TM_0908	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TM_0909	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TM_0910	COG1684	flagellar biosynthetic protein fliR
TM_0911	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TM_0913	COG3956	TIGRFAM MazG family protein
TM_0914	COG1392	Phosphate transport regulator
TM_0915	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TM_0917	COG0306	phosphate transporter
TM_0918	COG0840	transmembrane signaling receptor activity
TM_0922	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TM_0922	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TM_0925	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TM_0926	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TM_0927	COG1141	Ferredoxin
TM_0929	COG3864	Putative metallopeptidase domain
TM_0934	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TM_0935	COG0516	GMP reductase activity
TM_0935	COG0517	IMP dehydrogenase activity
TM_0936	COG0402	S-adenosylhomocysteine deaminase activity
TM_0939	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TM_0943	COG0174	glutamine synthetase
TM_0952	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
TM_0953	COG3958	Transketolase
TM_0954	COG3959	Transketolase, thiamine diphosphate binding domain
TM_0955	COG1172	Belongs to the binding-protein-dependent transport system permease family
TM_0956	COG1129	ABC transporter
TM_0958	COG1879	ABC-type sugar transport system periplasmic component
TM_0959	COG1869	D-ribose catabolic process
TM_0960	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TM_0961	COG1704	LemA family
TM_0964	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
TM_0965	COG1691	(AIR) carboxylase
TM_0966	COG1606	tRNA processing
TM_0967	COG4974	Belongs to the 'phage' integrase family
TM_0972	COG3706	GGDEF domain
TM_0973	COG0840	transmembrane signaling receptor activity
TM_0978	COG0425	Belongs to the sulfur carrier protein TusA family
TM_0982	COG2391	methyltransferase activity
TM_0983	COG0425	Belongs to the sulfur carrier protein TusA family
TM_0984	COG2373	Large extracellular alpha-helical protein
TM_0986	COG3234	Protein of unknown function (DUF1175)
TM_0990	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TM_0998	COG0640	Transcriptional regulator
TM_1000	COG1895	HEPN domain
TM_1005	COG2207	Transcriptional regulator
TM_1006	COG0667	Aldo Keto reductase
TM_1009	COG0656	L-ascorbic acid biosynthetic process
TM_1015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TM_1021	COG2814	Major facilitator Superfamily
TM_1028	COG1131	(ABC) transporter
TM_1033	COG0662	Cupin 2, conserved barrel domain protein
TM_1033	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TM_1034	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TM_1035	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TM_1035	COG0140	phosphoribosyl-ATP diphosphatase activity
TM_1036	COG0107	imidazoleglycerol-phosphate synthase activity
TM_1037	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TM_1038	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TM_1039	COG0131	Imidazoleglycerol-phosphate dehydratase
TM_1040	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TM_1041	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TM_1042	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TM_1043	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TM_1045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TM_1047	COG0850	regulation of cytokinetic process
TM_1052	COG1596	polysaccharide export
TM_1052	COG1555	photosystem II stabilization
TM_1054	COG1137	ATPase activity
TM_1056	COG1324	tolerance protein
TM_1057	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TM_1059	COG2359	stage V sporulation protein S
TM_1062	COG3250	beta-galactosidase activity
TM_1063	COG4608	Belongs to the ABC transporter superfamily
TM_1064	COG0444	Belongs to the ABC transporter superfamily
TM_1065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_1066	COG0601	transmembrane transport
TM_1067	COG0747	negative chemotaxis
TM_1068	COG1486	melibiose metabolic process
TM_1069	COG1349	DNA-binding transcription factor activity
TM_1071	COG4952	isomerase
TM_1073	COG1070	Carbohydrate kinase
TM_1077	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TM_1079	COG2264	protein methyltransferase activity
TM_1080	COG0698	ribose 5-phosphate isomerase
TM_1081	COG1366	Belongs to the anti-sigma-factor antagonist family
TM_1082	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TM_1083	COG1371	PFAM Archease protein family (DUF101 UPF0211)
TM_1084	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TM_1085	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM_1085	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TM_1089	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TM_1090	COG0124	histidyl-tRNA synthetase
TM_1093	COG0018	arginyl-trna synthetase
TM_1094	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TM_1095	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TM_1096	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TM_1097	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TM_1099	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TM_1101	COG0622	Phosphoesterase
TM_1102	COG0571	ribonuclease III activity
TM_1120	COG1653	transport
TM_1121	COG1175	transmembrane transport
TM_1123	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
TM_1129	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TM_1130	COG0280	phosphate acetyltransferase
TM_1131	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TM_1132	COG0714	Associated with various cellular activities
TM_1136	COG0559	Belongs to the binding-protein-dependent transport system permease family
TM_1138	COG0411	ABC transporter
TM_1139	COG0410	ABC transporter
TM_1141	COG0785	Cytochrome C biogenesis protein
TM_1143	COG0840	transmembrane signaling receptor activity
TM_1145	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TM_1145	COG2199	diguanylate cyclase activity
TM_1146	COG0840	transmembrane signaling receptor activity
TM_1150	COG0747	negative chemotaxis
TM_1151	COG4608	Belongs to the ABC transporter superfamily
TM_1152	COG0444	Belongs to the ABC transporter superfamily
TM_1153	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_1154	COG0363	glucosamine-6-phosphate deaminase activity
TM_1155	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TM_1156	COG1983	PspC domain protein
TM_1161	COG2239	Acts as a magnesium transporter
TM_1162	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TM_1163	COG2199	diguanylate cyclase activity
TM_1165	COG1013	pyruvate-flavodoxin oxidoreductase activity
TM_1166	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TM_1169	COG1028	Short-chain dehydrogenase reductase Sdr
TM_1172	COG1151	hydroxylamine reductase activity
TM_1177	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TM_1178	COG0456	acetyltransferase
TM_1179	COG1516	flagellar protein fliS
TM_1181	COG0494	nUDIX hydrolase
TM_1182	COG1196	nuclear chromosome segregation
TM_1183	COG0667	Aldo Keto reductase
TM_1185	COG1803	Methylglyoxal synthase
TM_1187	COG0628	permease
TM_1190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TM_1191	COG1085	galactose-1-phosphate uridylyltransferase
TM_1192	COG3345	alpha-galactosidase
TM_1193	COG3250	beta-galactosidase activity
TM_1194	COG0444	Belongs to the ABC transporter superfamily
TM_1196	COG4608	Belongs to the ABC transporter superfamily
TM_1197	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_1202	COG3833	ABC-type maltose transport systems, permease component
TM_1203	COG1175	transmembrane transport
TM_1204	COG2182	Extracellular solute-binding protein
TM_1205	COG1863	multisubunit Na H antiporter MnhE subunit
TM_1206	COG2212	antiporter activity
TM_1209	COG2111	Na H antiporter
TM_1209	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TM_1211	COG0651	ATP synthesis coupled electron transport
TM_1212	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TM_1214	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TM_1215	COG0649	NAD binding
TM_1215	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TM_1216	COG0649	NAD binding
TM_1219	COG4608	Belongs to the ABC transporter superfamily
TM_1220	COG0444	Belongs to the ABC transporter superfamily
TM_1221	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_1222	COG0601	transmembrane transport
TM_1223	COG4166	transmembrane transport
TM_1224	COG1940	carbohydrate kinase activity
TM_1225	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
TM_1226	COG0747	negative chemotaxis
TM_1229	COG0463	Glycosyl transferase, family 2
TM_1230	COG0438	transferase activity, transferring glycosyl groups
TM_1231	COG0383	alpha-mannosidase activity
TM_1232	COG3842	ATPase activity
TM_1238	COG0210	DNA helicase
TM_1240	COG0012	GTP binding
TM_1243	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TM_1244	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TM_1245	COG0047	phosphoribosylformylglycinamidine synthase activity
TM_1246	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TM_1247	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TM_1248	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TM_1249	COG0138	bifunctional purine biosynthesis protein purh
TM_1250	COG0151	Belongs to the GarS family
TM_1253	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TM_1253	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TM_1254	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TM_1255	COG0436	Aminotransferase
TM_1256	COG1132	(ABC) transporter
TM_1259	COG0745	RESPONSE REGULATOR receiver
TM_1260	COG0704	Plays a role in the regulation of phosphate uptake
TM_1261	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TM_1264	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TM_1269	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TM_1270	COG0626	cystathionine gamma-synthase activity
TM_1272	COG0154	amidase activity
TM_1273	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TM_1276	COG3842	ATPase activity
TM_1278	COG1193	negative regulation of DNA recombination
TM_1281	COG1486	melibiose metabolic process
TM_1283	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TM_1286	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TM_1287	COG0662	Cupin 2, conserved barrel domain protein
TM_1288	COG0731	radical SAM domain protein
TM_1288	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TM_1291	COG2894	cell division
TM_1292	COG0489	protein tyrosine kinase activity
TM_1293	COG2226	methyltransferase
TM_1295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TM_1297	COG0667	Aldo Keto reductase
TM_1302	COG4555	ABC transporter
TM_1310	COG1132	(ABC) transporter
TM_1311	COG1598	PFAM Uncharacterised protein family UPF0150
TM_1313	COG1598	PFAM Uncharacterised protein family UPF0150
TM_1314	COG0457	Tetratricopeptide repeat
TM_1319	COG1132	(ABC) transporter
TM_1321	COG1598	PFAM Uncharacterised protein family UPF0150
TM_1324	COG0641	radical SAM
TM_1327	COG4555	ABC transporter
TM_1328	COG1132	(ABC) transporter
TM_1344	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TM_1345	COG1185	polyribonucleotide nucleotidyltransferase activity
TM_1346	COG0612	Peptidase, M16
TM_1347	COG0517	IMP dehydrogenase activity
TM_1347	COG0516	GMP reductase activity
TM_1349	COG0628	permease
TM_1350	COG2267	carboxylic ester hydrolase activity
TM_1351	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TM_1354	COG0516	GMP reductase activity
TM_1354	COG0517	IMP dehydrogenase activity
TM_1359	COG3852	Histidine kinase
TM_1360	COG0745	RESPONSE REGULATOR receiver
TM_1361	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TM_1363	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TM_1364	COG1815	bacterial-type flagellum-dependent cell motility
TM_1366	COG1677	Flagellar hook-basal body complex protein FliE
TM_1368	COG0396	ATPase activity
TM_1369	COG0719	Fe-S assembly protein
TM_1371	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TM_1372	COG0822	iron-sulfur transferase activity
TM_1374	COG0406	alpha-ribazole phosphatase activity
TM_1375	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TM_1376	COG3842	ATPase activity
TM_1377	COG1176	ABC-type spermidine putrescine transport system, permease component I
TM_1378	COG1177	transmembrane transport
TM_1379	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TM_1383	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TM_1384	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
TM_1385	COG0166	Belongs to the GPI family
TM_1387	COG0237	dephospho-CoA kinase activity
TM_1388	COG0742	ribosomal rna small subunit methyltransferase
TM_1391	COG0542	response to heat
TM_1393	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TM_1394	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TM_1396	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TM_1397	COG0575	Belongs to the CDS family
TM_1398	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TM_1399	COG0233	cytoplasmic translational termination
TM_1400	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TM_1401	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TM_1405	COG0438	transferase activity, transferring glycosyl groups
TM_1410	COG2342	PFAM TM1410 hypothetical-related protein
TM_1414	COG1621	beta-fructofuranosidase activity
TM_1415	COG0483	inositol monophosphate 1-phosphatase activity
TM_1416	COG0719	Fe-S assembly protein
TM_1417	COG0396	ATPase activity
TM_1420	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TM_1424	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TM_1427	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TM_1428	COG0840	transmembrane signaling receptor activity
TM_1429	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TM_1431	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
TM_1437	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TM_1440	COG2050	protein possibly involved in aromatic compounds catabolism
TM_1440	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TM_1441	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TM_1442	COG1366	Belongs to the anti-sigma-factor antagonist family
TM_1443	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TM_1444	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TM_1446	COG1160	GTP binding
TM_1447	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TM_1450	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TM_1451	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TM_1452	COG0358	DNA primase activity
TM_1453	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TM_1454	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TM_1455	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
TM_1456	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TM_1458	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TM_1461	COG0706	membrane insertase activity
TM_1462	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TM_1463	COG0594	ribonuclease P activity
TM_1464	COG2313	pseudouridylate synthase activity
TM_1465	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TM_1466	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TM_1467	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TM_1468	COG1307	EDD domain protein, DegV family
TM_1469	COG1940	carbohydrate kinase activity
TM_1470	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TM_1471	COG0203	ribosomal protein L17
TM_1472	COG0202	RNA polymerase activity
TM_1473	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TM_1474	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TM_1475	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TM_1476	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TM_1479	COG0563	adenylate kinase activity
TM_1480	COG0201	protein transport
TM_1481	COG0200	Binds to the 23S rRNA
TM_1482	COG1841	ribosomal large subunit assembly
TM_1483	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TM_1484	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TM_1485	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TM_1486	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TM_1487	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TM_1488	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TM_1489	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TM_1490	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TM_1491	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TM_1492	COG0255	Belongs to the universal ribosomal protein uL29 family
TM_1493	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TM_1494	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TM_1495	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TM_1496	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TM_1497	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TM_1498	COG0089	rRNA binding
TM_1499	COG0088	Forms part of the polypeptide exit tunnel
TM_1500	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TM_1501	COG0051	transcription antitermination factor activity, RNA binding
TM_1502	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TM_1503	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TM_1504	COG0049	tRNA binding
TM_1505	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TM_1507	COG1702	phosphate starvation-inducible protein PhoH
TM_1508	COG1480	7TM receptor with intracellular HD hydrolase
TM_1509	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TM_1511	COG2738	Putative neutral zinc metallopeptidase
TM_1512	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TM_1512	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TM_1513	COG1323	Belongs to the UPF0348 family
TM_1516	COG1473	amidohydrolase
TM_1517	COG0019	diaminopimelate decarboxylase activity
TM_1519	COG2171	N-acyltransferase activity
TM_1520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
TM_1521	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TM_1522	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
TM_1523	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TM_1527	COG1959	2 iron, 2 sulfur cluster binding
TM_1528	COG1575	Belongs to the MenA family. Type 1 subfamily
TM_1530	COG2086	electron transfer activity
TM_1531	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TM_1532	COG0644	oxidoreductase
TM_1537	COG1032	radical SAM domain protein
TM_1539	COG1706	bacterial-type flagellum-dependent cell motility
TM_1540	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
TM_1543	COG4786	Flagellar basal body rod
TM_1545	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TM_1546	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
TM_1546	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TM_1547	COG1078	dGTPase activity
TM_1548	COG1086	Polysaccharide biosynthesis protein
TM_1549	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TM_1550	COG3872	metal-dependent enzyme
TM_1551	COG2078	PFAM AMMECR1 domain protein
TM_1553	COG1477	protein flavinylation
TM_1556	COG0424	maF-like protein
TM_1557	COG2003	Belongs to the UPF0758 family
TM_1559	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TM_1561	COG0343	queuine tRNA-ribosyltransferase activity
TM_1564	COG1254	Belongs to the acylphosphatase family
TM_1565	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TM_1566	COG0228	four-way junction DNA binding
TM_1567	COG1837	Belongs to the UPF0109 family
TM_1568	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TM_1569	COG0336	Belongs to the RNA methyltransferase TrmD family
TM_1570	COG4752	Belongs to the RNA methyltransferase TrmD family
TM_1571	COG0335	large ribosomal subunit rRNA binding
TM_1572	COG0681	Belongs to the peptidase S26 family
TM_1574	COG0101	tRNA pseudouridine synthase activity
TM_1576	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TM_1578	COG0653	protein targeting
TM_1579	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TM_1584	COG1040	competence protein
TM_1585	COG2379	hydroxypyruvate reductase
TM_1588	COG2203	Gaf domain
TM_1588	COG2199	diguanylate cyclase activity
TM_1590	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TM_1591	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TM_1592	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TM_1593	COG0489	protein tyrosine kinase activity
TM_1594	COG3706	GGDEF domain
TM_1595	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TM_1596	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TM_1597	COG3457	Alanine racemase
TM_1598	COG1595	DNA-templated transcription, initiation
TM_1601	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM_1602	COG1827	regulation of RNA biosynthetic process
TM_1603	COG0477	Major facilitator Superfamily
TM_1604	COG0528	UMP kinase activity
TM_1605	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TM_1606	COG1530	ribonuclease E activity
TM_1607	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TM_1608	COG1307	EDD domain protein, DegV family
TM_1609	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TM_1610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TM_1611	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TM_1612	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TM_1613	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TM_1614	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TM_1615	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TM_1616	COG0356	it plays a direct role in the translocation of protons across the membrane
TM_1618	COG1406	Chemotaxis phosphatase CheX
TM_1619	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TM_1619	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TM_1621	COG0584	glycerophosphoryl diester phosphodiesterase
TM_1623	COG0481	GTPase activity
TM_1624	COG3250	beta-galactosidase activity
TM_1626	COG0193	aminoacyl-tRNA hydrolase activity
TM_1627	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TM_1628	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TM_1629	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TM_1632	COG0802	atpase or kinase
TM_1633	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TM_1635	COG0420	3'-5' exonuclease activity
TM_1636	COG0419	ATPase involved in DNA repair
TM_1638	COG4555	ABC transporter
TM_1639	COG0543	2 iron, 2 sulfur cluster binding
TM_1641	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
TM_1642	COG0540	Belongs to the ATCase OTCase family
TM_1642	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
TM_1643	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
TM_1644	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TM_1645	COG0157	Belongs to the NadC ModD family
TM_1648	COG1713	HD superfamily hydrolase involved in NAD metabolism
TM_1651	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TM_1654	COG5002	protein histidine kinase activity
TM_1655	COG0745	RESPONSE REGULATOR receiver
TM_1657	COG0268	Binds directly to 16S ribosomal RNA
TM_1658	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TM_1661	COG0242	peptide deformylase activity
TM_1662	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TM_1663	COG1122	ATPase activity
TM_1664	COG2813	Specifically methylates the guanine in position
TM_1666	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TM_1667	COG2115	Belongs to the xylose isomerase family
TM_1672	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
TM_1682	COG3437	response regulator, receiver
TM_1683	COG1278	Cold shock
TM_1684	COG0254	rRNA binding
TM_1685	COG1185	polyribonucleotide nucleotidyltransferase activity
TM_1686	COG1376	ErfK ybiS ycfS ynhG family protein
TM_1687	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TM_1688	COG1758	RNA polymerase activity
TM_1689	COG0194	GDP metabolic process
TM_1694	COG0301	tRNA thio-modification
TM_1699	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TM_1701	COG0534	Mate efflux family protein
TM_1703	COG1368	sulfuric ester hydrolase activity
TM_1705	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TM_1706	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TM_1707	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TM_1709	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TM_1713	COG1739	Uncharacterized protein family UPF0029
TM_1714	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TM_1715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TM_1717	COG1162	GTPase activity
TM_1718	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TM_1719	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TM_1720	COG2153	protein acetylation
TM_1723	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TM_1724	COG1028	Short-chain dehydrogenase reductase Sdr
TM_1728	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TM_1730	COG2255	four-way junction helicase activity
TM_1731	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TM_1733	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TM_1734	COG0704	Plays a role in the regulation of phosphate uptake
TM_1736	COG0305	Participates in initiation and elongation during chromosome replication
TM_1737	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TM_1740	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
TM_1741	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TM_1742	COG0647	UMP catabolic process
TM_1743	COG0667	Aldo Keto reductase
TM_1747	COG0601	transmembrane transport
TM_1748	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TM_1750	COG4608	Belongs to the ABC transporter superfamily
TM_1753	COG0556	nucleotide-excision repair
TM_1754	COG3426	butyrate kinase activity
TM_1755	COG0280	phosphate acetyltransferase
TM_1756	COG3426	butyrate kinase activity
TM_1761	COG0556	nucleotide-excision repair
TM_1763	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TM_1765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TM_1766	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TM_1767	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TM_1768	COG1570	exodeoxyribonuclease VII activity
TM_1769	COG1722	exodeoxyribonuclease VII activity
TM_1770	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TM_1774	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TM_1776	COG0735	belongs to the Fur family
TM_1777	COG0195	Participates in both transcription termination and antitermination
TM_1778	COG0779	Required for maturation of 30S ribosomal subunits
TM_1780	COG0137	argininosuccinate synthase activity
TM_1782	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TM_1783	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TM_1784	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TM_1785	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TM_1796	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TM_1797	COG1518	maintenance of DNA repeat elements
TM_1803	COG0484	heat shock protein binding
TM_1809	COG1337	RAMP superfamily
TM_1811	COG1353	crispr-associated protein
TM_1817	COG0525	valine-tRNA ligase activity
TM_1818	COG2059	Chromate
TM_1820	COG0519	Catalyzes the synthesis of GMP from XMP
TM_1820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TM_1821	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
TM_1822	COG0330	HflC and HflK could
TM_1823	COG0330	HflC and HflK could
TM_1825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TM_1826	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM_1826	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TM_1828	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TM_1828	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TM_1830	COG3706	GGDEF domain
TM_1833	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
TM_1834	COG1486	melibiose metabolic process
TM_1835	COG0366	Alpha amylase catalytic
TM_1839	COG2182	Extracellular solute-binding protein
TM_1840	COG0366	Alpha amylase catalytic
TM_1845	COG1523	belongs to the glycosyl hydrolase 13 family
TM_1847	COG1940	carbohydrate kinase activity
TM_1848	COG3459	Glycosyltransferase 36 associated
TM_1853	COG0395	ABC-type sugar transport system, permease component
TM_1856	COG1609	Transcriptional regulator
TM_1857	COG1418	mRNA catabolic process
TM_1858	COG2137	regulation of response to DNA damage stimulus
TM_1859	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TM_1860	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TM_1861	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TM_1862	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TM_1865	COG1515	deoxyribonuclease V activity
TM_1867	COG0039	L-malate dehydrogenase activity
TM_1868	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
TM_1869	COG1067	ATP-dependent peptidase activity
TM_1870	COG2894	cell division
TM_1872	COG0432	Pfam Uncharacterised protein family UPF0047
TM_1874	COG1278	Cold shock
TM_1875	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TM_1876	COG0622	Phosphoesterase
TM_1878	COG0737	Belongs to the 5'-nucleotidase family