locus-tag	class	description
THMA_0002	ENOG4105DTQ	mandelate racemase muconate lactonizing
THMA_0004	ENOG4106IPI	cyclase, family
THMA_0006	ENOG4107QIZ	NADH dehydrogenase
THMA_0008	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
THMA_0011	ENOG4105EJ5	oxidoreductase gamma subunit
THMA_0012	ENOG4105WGB	oxidoreductase, delta subunit
THMA_0013	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
THMA_0014	ENOG4105DDK	oxidoreductase, beta subunit
THMA_0015	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
THMA_0016	ENOG4105WMR	Protein CrcB homolog
THMA_0017	ENOG4105KJJ	Uncharacterized ACR, COG1993
THMA_0018	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
THMA_0019	ENOG4105C8Q	Methyl-accepting chemotaxis
THMA_0023	ENOG4108JQ7	(ABC) transporter
THMA_0027	ENOG4108J59	Extracellular solute-binding protein, family 5
THMA_0032	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
THMA_0033	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMA_0034	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
THMA_0037	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THMA_0038	ENOG4105DC7	peptidase M24
THMA_0039	ENOG4105BZ1	(ABC) transporter
THMA_0043	ENOG4105D7V	transposase
THMA_0047	ENOG4105CE1	Ferrous iron transport protein b
THMA_0051	ENOG4105D0H	Alpha-glucuronidase (EC 3.2.1.139)
THMA_0053	ENOG4108JQ7	(ABC) transporter
THMA_0054	ENOG4105C3U	ABC transporter
THMA_0055	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_0056	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMA_0057	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
THMA_0060	ENOG4105D2H	Uronic isomerase
THMA_0061	ENOG4107258	Transcriptional regulator
THMA_0062	ENOG4108UHU	Aldolase
THMA_0064	ENOG4105DEI	Mannitol dehydrogenase
THMA_0065	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
THMA_0066	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
THMA_0068	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMA_0069	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_0070	ENOG4105C3U	ABC transporter
THMA_0071	ENOG4108JQ7	(ABC) transporter
THMA_0073	ENOG4105I82	acetyl xylan esterase
THMA_0074	ENOG4105E0A	ABC, transporter
THMA_0075	ENOG4105EHG	Permease protein
THMA_0076	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
THMA_0077	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
THMA_0078	ENOG4105DTJ	flagellar hook-associated protein
THMA_0082	ENOG4105CJR	Integral membrane protein (MviN
THMA_0083	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
THMA_0091	ENOG4105FBB	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity)
THMA_0092	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
THMA_0093	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
THMA_0094	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMA_0096	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
THMA_0098	ENOG4105DIH	basic membrane
THMA_0099	ENOG4108JQ9	ABC transporter
THMA_0100	ENOG4105UIB	(ABC) transporter
THMA_0104	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
THMA_0106	ENOG4105E2R	ROK family
THMA_0108	ENOG4105CNN	ABC, transporter
THMA_0111	ENOG4105C2J	ABC transporter
THMA_0112	ENOG4105CMG	Carbohydrate kinase
THMA_0116	ENOG4108TVJ	Nitroreductase
THMA_0117	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
THMA_0119	ENOG4107XSR	periplasmic solute binding protein
THMA_0120	ENOG4105FDK	ABC transporter
THMA_0121	ENOG41080V6	ABC-3 protein
THMA_0122	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
THMA_0124	ENOG4107QSA	Oxaloacetate decarboxylase
THMA_0127	ENOG4105I03	Flagellin
THMA_0128	ENOG4108W2Y	isochorismatase
THMA_0129	ENOG4105C3M	thioredoxin reductase
THMA_0131	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
THMA_0132	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
THMA_0133	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THMA_0134	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
THMA_0135	ENOG4105DK0	Indole-3-glycerol phosphate synthase
THMA_0136	ENOG4105DDQ	anthranilate synthase
THMA_0137	ENOG4105CRQ	synthase (Component I)
THMA_0141	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THMA_0142	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
THMA_0143	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
THMA_0144	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
THMA_0145	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
THMA_0146	ENOG41085U1	50S ribosomal protein L32
THMA_0150	ENOG4105CQC	Prephenate dehydratase
THMA_0151	ENOG4105G6Z	alkaline phosphatase
THMA_0154	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
THMA_0155	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
THMA_0161	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
THMA_0162	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
THMA_0163	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
THMA_0164	ENOG4105C8T	Leucyl-tRNA synthetase
THMA_0165	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
THMA_0167	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
THMA_0168	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
THMA_0169	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
THMA_0170	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THMA_0171	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
THMA_0174	ENOG4105C25	Primosomal protein n'
THMA_0183	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THMA_0185	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
THMA_0187	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMA_0188	ENOG4105BZU	Histidine kinase
THMA_0191	ENOG4105S10	periplasmic binding protein
THMA_0192	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
THMA_0193	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
THMA_0194	ENOG4105MCT	stage V sporulation protein S
THMA_0199	ENOG4105C4B	ABC transporter, permease
THMA_0200	ENOG4108T5I	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THMA_0204	ENOG4107R56	PP-loop domain protein
THMA_0205	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THMA_0206	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
THMA_0207	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
THMA_0208	ENOG4107QHI	-hydrogenase
THMA_0213	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
THMA_0214	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
THMA_0215	ENOG4105CA9	Pyruvate kinase
THMA_0216	ENOG4105CTQ	phosphohexokinase
THMA_0218	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
THMA_0219	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
THMA_0220	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMA_0221	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMA_0222	ENOG4105KME	endoribonuclease L-psp
THMA_0223	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
THMA_0224	ENOG4107RFA	Glycyl-tRNA synthetase beta subunit
THMA_0226	ENOG4105W2B	Flagellar assembly protein
THMA_0227	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
THMA_0228	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
THMA_0229	ENOG4108JJB	ABC transporter
THMA_0231	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
THMA_0232	ENOG4105K6H	D-cysteine desulfhydrase
THMA_0234	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
THMA_0235	ENOG4107QIZ	NADH dehydrogenase
THMA_0238	ENOG4105DFU	Cell wall formation (By similarity)
THMA_0239	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
THMA_0240	ENOG4105CNI	cell division protein FtsW
THMA_0241	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
THMA_0242	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
THMA_0243	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
THMA_0244	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
THMA_0246	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
THMA_0250	ENOG4107QSQ	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
THMA_0251	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
THMA_0252	ENOG4105D6A	Electron transport complex
THMA_0254	ENOG4105DZB	Electron transport complex
THMA_0256	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
THMA_0257	ENOG4105C79	DNA protecting protein DprA
THMA_0258	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
THMA_0259	ENOG41084A9	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THMA_0260	ENOG41085R6	UPF0102 protein
THMA_0261	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
THMA_0265	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
THMA_0268	ENOG4105CJ3	phosphate transporter
THMA_0269	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
THMA_0270	ENOG4105CWE	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
THMA_0271	ENOG4105I08	Pseudouridine synthase
THMA_0272	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
THMA_0273	ENOG4105K70	DNA-binding protein
THMA_0274	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
THMA_0275	ENOG4105C3R	Methionine synthase
THMA_0279	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
THMA_0280	ENOG4105D2N	Aldolase
THMA_0281	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
THMA_0283	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
THMA_0286	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
THMA_0288	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
THMA_0289	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
THMA_0290	ENOG4105CR5	Class II aldolase adducin family protein
THMA_0291	ENOG4105CMG	Carbohydrate kinase
THMA_0292	ENOG4108MDK	Dehydrogenase
THMA_0294	ENOG4105BZ1	(ABC) transporter
THMA_0295	ENOG4105BZ1	(ABC) transporter
THMA_0296	ENOG4107UUY	ec 2.7.1.11
THMA_0297	ENOG4105BZN	citrate synthase
THMA_0298	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMA_0299	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMA_0300	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
THMA_0301	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
THMA_0302	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
THMA_0303	ENOG4105D7K	pfkb domain protein
THMA_0304	ENOG4105CHR	reductase
THMA_0305	ENOG4105CPQ	Dehydrogenase
THMA_0306	ENOG4105ETE	Transcriptional regulator (LacI family
THMA_0308	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMA_0309	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_0310	ENOG4108JQ7	(ABC) transporter
THMA_0315	ENOG4105CJQ	hydrolase, family 31
THMA_0319	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
THMA_0320	ENOG4105CPC	Aldo Keto reductase
THMA_0324	ENOG4105C59	p-type ATPase
THMA_0325	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
THMA_0329	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
THMA_0331	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
THMA_0332	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
THMA_0333	ENOG4106KNT	transcriptional regulator
THMA_0334	ENOG4108JQ1	Dehydrogenase
THMA_0338	ENOG4105EFZ	amidohydrolase
THMA_0339	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
THMA_0340	ENOG4107YPM	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
THMA_0341	ENOG4107W93	Dihydroorotate dehydrogenase
THMA_0342	ENOG4105I47	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
THMA_0343	ENOG4107VJ5	dihydroorotase
THMA_0344	ENOG4105F6J	Alpha beta hydrolase fold
THMA_0345	ENOG4105CCT	upf0313 protein
THMA_0351	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
THMA_0353	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
THMA_0354	ENOG4108237	shikimate dehydrogenase
THMA_0355	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
THMA_0356	ENOG4105D49	3-dehydroquinate synthase
THMA_0357	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
THMA_0359	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THMA_0360	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THMA_0361	ENOG410624X	efflux transporter, rnd family, mfp subunit
THMA_0364	ENOG4105C7B	Threonine dehydratase
THMA_0366	ENOG4105CBD	Diacylglycerol kinase
THMA_0368	ENOG4105DXN	mazG family
THMA_0370	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
THMA_0372	ENOG4105CG3	alpha amylase, catalytic region
THMA_0373	ENOG4105DFM	M18 family aminopeptidase
THMA_0374	ENOG4105CSM	endonuclease III
THMA_0378	ENOG4105EHU	Circadian clock protein KaiC
THMA_0381	ENOG4105CFG	Acts as a chaperone (By similarity)
THMA_0382	ENOG4105VN1	Heat shock protein
THMA_0383	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
THMA_0384	ENOG4105EJ9	Membrane
THMA_0385	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
THMA_0386	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
THMA_0389	ENOG4105CEN	a g-specific adenine glycosylase
THMA_0390	ENOG4108TVJ	Nitroreductase
THMA_0392	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
THMA_0393	ENOG4108TVJ	Nitroreductase
THMA_0396	ENOG4105CJ1	ABC, transporter
THMA_0397	ENOG41088YS	Glycosyl transferase (Group 1
THMA_0401	ENOG4105BZ8	glutamate synthase
THMA_0403	ENOG4105EYU	Glutamine amido-transferase
THMA_0406	ENOG41062D9	Histidine kinase
THMA_0407	ENOG4107104	thymidine kinase
THMA_0409	ENOG4108YZA	Nitrogen regulatory protein pii
THMA_0411	ENOG4105DQU	oxidoreductase, subunit beta
THMA_0414	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
THMA_0415	ENOG4105DR5	peptidase
THMA_0418	ENOG4105CPQ	Dehydrogenase
THMA_0419	ENOG4107W9I	Creatinine amidohydrolase
THMA_0420	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
THMA_0422	ENOG4107S8A	protein TIM barrel
THMA_0425	ENOG4105D56	permease protein
THMA_0426	ENOG4105EG2	ABC transporter, permease
THMA_0429	ENOG4105DCT	glycerol dehydrogenase
THMA_0434	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
THMA_0435	ENOG4105C8Q	Methyl-accepting chemotaxis
THMA_0436	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
THMA_0439	ENOG4105DBA	pectate lyase
THMA_0440	ENOG4107V4V	glycoside hydrolase family 4
THMA_0444	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
THMA_0445	ENOG4108WYP	Transcriptional regulator
THMA_0447	ENOG4105CHR	reductase
THMA_0449	ENOG4105CMG	Carbohydrate kinase
THMA_0450	ENOG4108IJ0	Aspartate ammonia-lyase
THMA_0452	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
THMA_0453	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
THMA_0454	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMA_0455	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
THMA_0460	ENOG41086IP	50S ribosomal protein L33
THMA_0462	ENOG410683Z	Preprotein translocase SecE subunit
THMA_0463	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
THMA_0465	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
THMA_0466	ENOG41081WB	50s ribosomal protein L10
THMA_0467	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
THMA_0468	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THMA_0469	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THMA_0470	ENOG4105DEF	Extracellular solute-binding protein, family 5
THMA_0471	ENOG4105C0B	DNA polymerase III (alpha subunit)
THMA_0472	ENOG4105C34	Pseudouridine synthase
THMA_0473	ENOG4105BZU	Histidine kinase
THMA_0475	ENOG4105CDY	transcriptional regulatory protein
THMA_0477	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
THMA_0481	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
THMA_0484	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
THMA_0487	ENOG4105QZY	s-layer domain protein
THMA_0488	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
THMA_0490	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
THMA_0496	ENOG4108IY8	ABC, transporter
THMA_0498	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
THMA_0500	ENOG4105VG1	fes assembly suf system protein
THMA_0501	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
THMA_0503	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
THMA_0505	ENOG4105C31	Tryptophanyl-tRNA synthetase
THMA_0506	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
THMA_0507	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
THMA_0508	ENOG4108IAB	Phoh family
THMA_0509	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
THMA_0513	ENOG4108JQ7	(ABC) transporter
THMA_0514	ENOG4105C3U	ABC transporter
THMA_0515	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_0517	ENOG41083C3	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
THMA_0518	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
THMA_0520	ENOG4105D1H	recombination factor protein RarA
THMA_0523	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
THMA_0525	ENOG4105C0P	Mg chelatase subunit ChlI
THMA_0526	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
THMA_0527	ENOG4105N5T	Radical SAM Protein
THMA_0532	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
THMA_0533	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
THMA_0534	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
THMA_0538	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
THMA_0539	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
THMA_0540	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
THMA_0541	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
THMA_0542	ENOG410681U	heavy metal transport detoxification protein
THMA_0543	ENOG4108JQ7	(ABC) transporter
THMA_0546	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_0547	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THMA_0550	ENOG4106D4I	domain protein
THMA_0551	ENOG4105PGM	cation diffusion facilitator family transporter
THMA_0552	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THMA_0554	ENOG4107GFK	fumarate
THMA_0557	ENOG4105CJ1	ABC, transporter
THMA_0558	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
THMA_0559	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
THMA_0560	ENOG4105CFH	Aspartokinase
THMA_0561	ENOG4105C7K	acetolactate synthase
THMA_0564	ENOG4105C01	Dihydroxy-acid dehydratase
THMA_0565	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
THMA_0567	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMA_0568	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMA_0569	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
THMA_0570	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
THMA_0571	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
THMA_0574	ENOG4105D7N	magnesium and cobalt transport protein CorA
THMA_0579	ENOG4107ZMQ	sugar fermentation stimulation protein
THMA_0581	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
THMA_0584	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
THMA_0585	ENOG4105C0H	protease
THMA_0586	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
THMA_0587	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
THMA_0588	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
THMA_0589	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
THMA_0590	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
THMA_0591	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
THMA_0592	ENOG4105II7	pyrroline-5-carboxylate reductase
THMA_0594	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
THMA_0595	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
THMA_0598	ENOG4107QQG	Dehydrogenase
THMA_0601	ENOG410631K	Membrane
THMA_0602	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
THMA_0603	ENOG4105DFF	Rod shape-determining protein mreb
THMA_0606	ENOG4105CJN	penicillin-binding protein
THMA_0608	ENOG4105E5Q	amino acid AbC transporter
THMA_0609	ENOG4105EAB	amino acid AbC transporter
THMA_0610	ENOG4105C7N	Xanthine uracil vitamin C permease
THMA_0614	ENOG4105DRS	transport system, permease
THMA_0619	ENOG41083EQ	Binds together with S18 to 16S ribosomal RNA (By similarity)
THMA_0620	ENOG4108UUM	single-stranded DNA-binding protein
THMA_0621	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
THMA_0623	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THMA_0626	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
THMA_0635	ENOG4107RA4	Glycosyl transferase (Group 1
THMA_0638	ENOG4107STW	synthase
THMA_0640	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
THMA_0643	ENOG4107SBE	Glycosyl transferase (Group 1
THMA_0646	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
THMA_0649	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
THMA_0654	ENOG4105DAY	polysaccharide export protein
THMA_0660	ENOG4107S7H	nh(3)-dependent nad( ) synthetase
THMA_0662	ENOG41082Q0	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
THMA_0666	ENOG4105J7I	hydrolase
THMA_0668	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THMA_0669	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
THMA_0670	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
THMA_0671	ENOG4106A7E	Transcriptional regulator
THMA_0672	ENOG4108RAC	Rubrerythrin
THMA_0673	ENOG4108YZ8	Superoxide reductase
THMA_0674	ENOG4105VCQ	rubredoxin
THMA_0675	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
THMA_0677	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
THMA_0680	ENOG4105C6T	cysteine synthase
THMA_0682	ENOG4105F8V	Hydrolase, tatD family
THMA_0689	ENOG4105BZE	flagellar hook protein, FlgE
THMA_0690	ENOG41068WV	flagellar FlbD family protein
THMA_0691	ENOG4105E14	MotA TolQ exbB proton channel
THMA_0692	ENOG4105ER2	Ompa motb domain protein
THMA_0694	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
THMA_0695	ENOG4105DD5	Flagellar motor switch protein
THMA_0701	ENOG4105C6E	dna polymerase iii
THMA_0702	ENOG41085TI	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
THMA_0703	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
THMA_0704	ENOG4105BZA	Phosphoglycerate kinase
THMA_0707	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
THMA_0709	ENOG4107XYV	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity)
THMA_0710	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
THMA_0713	ENOG4105CN7	Flagellar biosynthetic protein FliP
THMA_0715	ENOG4107YTP	response regulator receiver protein
THMA_0716	ENOG4105YVF	chew protein
THMA_0717	ENOG4105CBS	Chea signal transduction histidine kinase
THMA_0718	ENOG4105CEV	competence damage-inducible protein
THMA_0719	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THMA_0720	ENOG4105C19	ABC transporter
THMA_0722	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
THMA_0723	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
THMA_0724	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
THMA_0731	ENOG4105D8K	carboxyl transferase
THMA_0733	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
THMA_0734	ENOG4105YFD	chemotaxis, protein
THMA_0735	ENOG4105C8N	cysteinyl-tRNA synthetase
THMA_0736	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
THMA_0737	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
THMA_0738	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
THMA_0742	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
THMA_0743	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
THMA_0747	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
THMA_0748	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
THMA_0749	ENOG4105WPN	DNA integration recombination invertion protein
THMA_0752	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
THMA_0754	ENOG4105DG6	mannose-6-phosphate isomerase
THMA_0757	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMA_0758	ENOG4105C22	threonyL-tRNA synthetase
THMA_0760	ENOG4107S1Q	Phosphatase
THMA_0762	ENOG4105BZF	Glycosyl transferase (Group 1
THMA_0765	ENOG4105CN1	protease
THMA_0766	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THMA_0769	ENOG4105DBI	uridine monophosphokinase
THMA_0771	ENOG4107V4V	glycoside hydrolase family 4
THMA_0772	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
THMA_0774	ENOG4105CNW	domain protein
THMA_0776	ENOG4107TVC	Glycosyl transferase, family 2
THMA_0781	ENOG4105CE9	30S ribosomal protein S2
THMA_0782	ENOG4105K8R	UPF0145 protein
THMA_0784	ENOG4105CJ1	ABC, transporter
THMA_0786	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
THMA_0787	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
THMA_0789	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THMA_0790	ENOG4107QRG	dna polymerase iii
THMA_0791	ENOG4105MA4	psp1 domain protein
THMA_0792	ENOG41061AI	Protein of unknown function (DUF2905)
THMA_0794	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
THMA_0806	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
THMA_0807	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
THMA_0809	ENOG4107ZCS	Phosphomethylpyrimidine kinase
THMA_0810	ENOG410816Z	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
THMA_0812	ENOG4105CJ1	ABC, transporter
THMA_0816	ENOG4108N5B	2-phosphosulfolactate phosphatase
THMA_0818	ENOG4105VKD	bioY protein
THMA_0819	ENOG4105EA8	2-Nitropropane dioxygenase
THMA_0820	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
THMA_0821	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
THMA_0822	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
THMA_0823	ENOG4107RU2	Histidinol phosphate phosphatase, HisJ family
THMA_0824	ENOG4105ESV	Glycosyl transferase, family 4
THMA_0826	ENOG4105D3R	alkyl hydroperoxide reductase
THMA_0827	ENOG4105E2R	ROK family
THMA_0831	ENOG4105DRS	transport system, permease
THMA_0832	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
THMA_0833	ENOG4105CE4	GlcNAc 6-P deacetylase
THMA_0834	ENOG4105UQX	Mate efflux family protein
THMA_0838	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
THMA_0840	ENOG4107QW4	alcohol dehydrogenase
THMA_0843	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
THMA_0846	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
THMA_0848	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
THMA_0849	ENOG4105DE4	1-phosphofructokinase
THMA_0851	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THMA_0852	ENOG4107Z5F	Aminotransferase class IV
THMA_0854	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THMA_0856	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
THMA_0857	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
THMA_0858	ENOG4107QHF	type ii secretion system protein e
THMA_0860	ENOG4105CNI	cell division protein FtsW
THMA_0863	ENOG4107YTP	response regulator receiver protein
THMA_0864	ENOG4105CCS	Glutamate formiminotransferase
THMA_0865	ENOG41082VF	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
THMA_0866	ENOG4108JU5	Magnesium and cobalt efflux protein
THMA_0867	ENOG4105KG3	cytidine deaminase
THMA_0868	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
THMA_0869	ENOG4105CQW	ribosome biogenesis GTPase YqeH
THMA_0870	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
THMA_0871	ENOG41085Z1	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THMA_0872	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
THMA_0874	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THMA_0875	ENOG4105BZU	Histidine kinase
THMA_0876	ENOG4108HU6	Metal dependent phosphohydrolase
THMA_0877	ENOG41084NJ	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
THMA_0878	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
THMA_0879	ENOG4105DTN	riboflavin biosynthesis protein ribF
THMA_0881	ENOG4107Z7W	Preprotein translocase YajC subunit
THMA_0882	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THMA_0883	ENOG4107VRQ	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THMA_0884	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
THMA_0885	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
THMA_0886	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
THMA_0890	ENOG4108JU3	Alkyl hydroperoxide reductase
THMA_0892	ENOG4105CJN	penicillin-binding protein
THMA_0894	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
THMA_0895	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THMA_0899	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
THMA_0900	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
THMA_0902	ENOG4105D9Q	decarboxylase (Beta subunit)
THMA_0903	ENOG4105CVG	Homoserine O-transsuccinylase
THMA_0905	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
THMA_0908	ENOG4105BZ4	penicillin-binding protein
THMA_0909	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
THMA_0911	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
THMA_0912	ENOG4105DZP	Membrane-associated zinc metalloprotease
THMA_0913	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
THMA_0914	ENOG4105CJW	magnesium transporter
THMA_0915	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
THMA_0917	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
THMA_0918	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
THMA_0919	ENOG4105MCT	stage V sporulation protein S
THMA_0924	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THMA_0925	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
THMA_0926	ENOG4107PHP	CheC --inhibitor of MCP methylation
THMA_0929	ENOG4105FZW	flagellar biosynthesis regulator FlhF
THMA_0930	ENOG4105D7B	Flagellar biosynthesis protein flha
THMA_0931	ENOG4105D00	flagellar biosynthetic protein flhB
THMA_0932	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
THMA_0933	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
THMA_0935	ENOG4105DXN	mazG family
THMA_0936	ENOG41080JC	Protein of unknown function DUF47
THMA_0937	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
THMA_0939	ENOG4105CJ3	phosphate transporter
THMA_0940	ENOG4105C8Q	Methyl-accepting chemotaxis
THMA_0944	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
THMA_0947	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
THMA_0948	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
THMA_0949	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
THMA_0950	ENOG41063SX	
THMA_0951	ENOG4105EZM	VWA-like domain (DUF2201)
THMA_0956	ENOG4107R3E	Citrate transporter
THMA_0957	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMA_0958	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
THMA_0961	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
THMA_0962	ENOG4105EI2	Pseudouridine synthase
THMA_0966	ENOG4105C5F	glutamine synthetase
THMA_0975	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
THMA_0976	ENOG4108IUS	Transketolase
THMA_0977	ENOG4108HHA	Transketolase
THMA_0978	ENOG4105CNN	ABC, transporter
THMA_0979	ENOG4105C2J	ABC transporter
THMA_0981	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
THMA_0982	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
THMA_0983	ENOG4108RVA	ribokinase
THMA_0984	ENOG4108V0P	LemA family
THMA_0987	ENOG4108086	Protein of unknown function DUF111
THMA_0988	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
THMA_0990	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
THMA_0995	ENOG4105BZU	Histidine kinase
THMA_0996	ENOG4105C8Q	Methyl-accepting chemotaxis
THMA_1000	ENOG41084XP	SirA-like domain-containing protein
THMA_1004	ENOG4105CUC	YeeE YedE family protein
THMA_1005	ENOG41084XP	SirA-like domain-containing protein
THMA_1006	ENOG4107S85	alpha-2-macroglobulin domain protein
THMA_1008	ENOG4108QJJ	Protein of unknown function (DUF1175)
THMA_1012	ENOG4105C0D	helicase
THMA_1022	ENOG41060KZ	Hepn domain protein
THMA_1028	ENOG4105CF7	AraC family transcriptional regulator
THMA_1029	ENOG4107SET	aldo keto reductase
THMA_1031	ENOG4105CV8	reductase
THMA_1037	ENOG4105D82	Glutamate dehydrogenase
THMA_1042	ENOG4107RCC	Major Facilitator Superfamily
THMA_1050	ENOG4105CIG	ABC transporter
THMA_1055	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
THMA_1056	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
THMA_1057	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
THMA_1058	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
THMA_1060	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
THMA_1062	ENOG4105CIH	Imidazole acetol-phosphate transaminase
THMA_1063	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
THMA_1066	ENOG4105D7V	transposase
THMA_1069	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
THMA_1074	ENOG4105KQC	Competence protein
THMA_1076	ENOG4108IUZ	ABC transporter
THMA_1078	ENOG4108531	cuta1 divalent ion tolerance protein
THMA_1079	ENOG4107SVH	Potassium channel protein
THMA_1081	ENOG4105MCT	stage V sporulation protein S
THMA_1084	ENOG4105CNT	hydrolase family 2
THMA_1085	ENOG4108JQ7	(ABC) transporter
THMA_1086	ENOG4105C3U	ABC transporter
THMA_1087	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_1088	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMA_1090	ENOG4107V4V	glycoside hydrolase family 4
THMA_1091	ENOG4105E98	transcriptional regulator DeoR family
THMA_1093	ENOG4105C9F	isomerase
THMA_1095	ENOG4105DET	Rhamnulokinase
THMA_1099	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
THMA_1101	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
THMA_1102	ENOG4108YZG	isomerase
THMA_1103	ENOG410682B	stage II sporulation protein
THMA_1104	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
THMA_1105	ENOG4106FU4	Archease protein family (MTH1598/TM1083)
THMA_1106	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THMA_1107	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
THMA_1110	ENOG4107VEG	TrkA-N domain protein
THMA_1112	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
THMA_1113	ENOG4105CUT	histidyl-tRNA synthetase
THMA_1116	ENOG4105C75	arginyL-tRNA synthetase
THMA_1117	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
THMA_1118	ENOG4105C83	adenylosuccinate lyase
THMA_1119	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
THMA_1120	ENOG4105DBV	ornithine carbamoyltransferase
THMA_1122	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
THMA_1124	ENOG4108RE9	Phosphodiesterase
THMA_1125	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
THMA_1128	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THMA_1146	ENOG4107V1F	Flagellar hook-associated 2 domain-containing protein
THMA_1152	ENOG41083B7	nucleosidase (EC 3.2.2.9)
THMA_1153	ENOG4107RE7	phosphate butyryltransferase
THMA_1154	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
THMA_1155	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
THMA_1159	ENOG4105C32	Amino acid ABC transporter (Permease)
THMA_1160	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
THMA_1161	ENOG4105C0Z	ABC transporter
THMA_1162	ENOG4108IV0	ABC, transporter
THMA_1163	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMA_1164	ENOG4107QIV	Cytochrome c biogenesis protein
THMA_1166	ENOG4105C8Q	Methyl-accepting chemotaxis
THMA_1168	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMA_1170	ENOG4105C8Q	Methyl-accepting chemotaxis
THMA_1171	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMA_1173	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMA_1174	ENOG4105DEF	Extracellular solute-binding protein, family 5
THMA_1175	ENOG4108JQ7	(ABC) transporter
THMA_1178	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
THMA_1179	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
THMA_1180	ENOG41067S9	phage shock protein C, PspC
THMA_1186	ENOG4105CJW	magnesium transporter
THMA_1187	ENOG4105E8R	UPF0173 metal-dependent hydrolase
THMA_1188	ENOG4108KHP	Diguanylate cyclase
THMA_1190	ENOG4105DQU	oxidoreductase, subunit beta
THMA_1191	ENOG4105CSA	Coproporphyrinogen iii oxidase
THMA_1193	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
THMA_1194	ENOG4105CHR	reductase
THMA_1195	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMA_1197	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
THMA_1202	ENOG4107VXZ	Hydrolase
THMA_1203	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
THMA_1204	ENOG4105MQ3	flagellar protein FliS
THMA_1206	ENOG4108YZ4	nudix hydrolase
THMA_1207	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
THMA_1208	ENOG4107SET	aldo keto reductase
THMA_1209	ENOG4105BZU	Histidine kinase
THMA_1210	ENOG4108Z5K	methylglyoxal synthase
THMA_1212	ENOG4107WSY	Domain of unknown function DUF20
THMA_1216	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
THMA_1217	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
THMA_1218	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
THMA_1219	ENOG4105CNT	hydrolase family 2
THMA_1222	ENOG4108JQ7	(ABC) transporter
THMA_1223	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_1226	ENOG4105ETE	Transcriptional regulator (LacI family
THMA_1228	ENOG4105EG2	ABC transporter, permease
THMA_1229	ENOG4105D56	permease protein
THMA_1230	ENOG4107FKK	extracellular solute-binding protein family 1
THMA_1231	ENOG4105SC1	monovalent cation H antiporter subunit E
THMA_1232	ENOG410684G	monovalent cation H antiporter subunit F
THMA_1235	ENOG4105D65	subunit l
THMA_1237	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THMA_1240	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THMA_1241	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THMA_1242	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THMA_1244	ENOG4105ETE	Transcriptional regulator (LacI family
THMA_1245	ENOG4108JQ7	(ABC) transporter
THMA_1247	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_1248	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMA_1249	ENOG4108J59	Extracellular solute-binding protein, family 5
THMA_1250	ENOG4105E2R	ROK family
THMA_1251	ENOG4105CKB	glycosidase
THMA_1252	ENOG4107QRA	Extracellular solute-binding protein, family 5
THMA_1255	ENOG4106J7S	Glycosyl transferase, family 2
THMA_1256	ENOG4105IRK	Glycosyl transferase (Group 1
THMA_1257	ENOG4105C8I	hydrolase, family 38
THMA_1258	ENOG4108IJ9	(ABC) transporter
THMA_1263	ENOG4105C4R	Atp-dependent dna helicase
THMA_1265	ENOG4105C3G	gtp-binding protein
THMA_1268	ENOG4105C8V	SAICAR synthetase
THMA_1269	ENOG4108A1T	Phosphoribosylformylglycinamidine synthase, purS
THMA_1270	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
THMA_1271	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
THMA_1273	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
THMA_1274	ENOG4105DC1	bifunctional purine biosynthesis protein purh
THMA_1275	ENOG4107QNG	Phosphoribosylglycinamide synthetase
THMA_1278	ENOG4105C4K	Nad synthetase
THMA_1279	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
THMA_1280	ENOG4105CHM	Aminotransferase
THMA_1281	ENOG4105BZ1	(ABC) transporter
THMA_1284	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THMA_1285	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
THMA_1286	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THMA_1289	ENOG4105CVA	phosphate
THMA_1294	ENOG4107QW8	radical SAM domain protein
THMA_1296	ENOG4105X0D	Fimbrial protein
THMA_1297	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
THMA_1298	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THMA_1302	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
THMA_1303	ENOG4105C98	muts2 protein
THMA_1306	ENOG4105F8D	glycoside hydrolase family 4
THMA_1307	ENOG41076QQ	Glycosyl transferase, family 2
THMA_1309	ENOG4108X8W	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
THMA_1313	ENOG4105W06	Cupin 2, conserved barrel domain protein
THMA_1314	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMA_1317	ENOG4107QMS	site-determining protein
THMA_1318	ENOG4105D1F	ATP-binding protein
THMA_1319	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
THMA_1321	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THMA_1323	ENOG4108FN7	Aldo keto reductase
THMA_1327	ENOG4108IUW	ABC transporter
THMA_1334	ENOG4105BZ1	(ABC) transporter
THMA_1335	ENOG4105ZVY	2-oxoisovalerate dehydrogenase, E1 component beta subunit
THMA_1337	ENOG4106HX1	Uncharacterised protein family (UPF0150)
THMA_1338	ENOG4105PGZ	NB-ARC domain
THMA_1342	ENOG4105BZ1	(ABC) transporter
THMA_1343	ENOG4105BZ1	(ABC) transporter
THMA_1345	ENOG4106HX1	Uncharacterised protein family (UPF0150)
THMA_1348	ENOG4105C4X	radical SAM domain protein
THMA_1351	ENOG4108IUW	ABC transporter
THMA_1352	ENOG4105BZ1	(ABC) transporter
THMA_1369	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
THMA_1371	ENOG4105C1V	Peptidase, M16
THMA_1372	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMA_1374	ENOG4107Z0G	Domain of unknown function DUF20
THMA_1375	ENOG4105E5G	Alpha beta hydrolase fold
THMA_1376	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
THMA_1379	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMA_1384	ENOG4105BZU	Histidine kinase
THMA_1385	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THMA_1386	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
THMA_1387	ENOG4105CZX	twitching motility protein
THMA_1388	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
THMA_1389	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
THMA_1390	ENOG4108ZC9	flagellar basal-body rod protein flgc
THMA_1391	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
THMA_1394	ENOG4105C3K	feS assembly ATPase SufC
THMA_1395	ENOG4105DIW	FeS assembly protein SUFB
THMA_1397	ENOG4105C9B	Cysteine desulfurase
THMA_1398	ENOG4107YH3	SUF system FeS assembly protein, NifU family
THMA_1400	ENOG4105CVJ	phosphoglycerate mutase
THMA_1402	ENOG4107RUE	extracellular solute-binding protein family 1
THMA_1403	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
THMA_1404	ENOG4105F38	ABC transporter, permease
THMA_1405	ENOG4105D38	putrescine abc transporter
THMA_1406	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
THMA_1407	ENOG4108TSD	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
THMA_1410	ENOG4107SJN	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
THMA_1411	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
THMA_1412	ENOG4105C89	phosphohexose isomerase
THMA_1414	ENOG41083IT	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
THMA_1415	ENOG4106H78	methyltransferase
THMA_1420	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THMA_1422	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
THMA_1423	ENOG4107S82	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
THMA_1425	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
THMA_1426	ENOG4105KNE	Phosphatidate cytidylyltransferase
THMA_1427	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
THMA_1429	ENOG4105C5R	Aminotransferase
THMA_1430	ENOG4108JQ1	Dehydrogenase
THMA_1434	ENOG4105CPK	Glycosyl transferase (Group 1
THMA_1439	ENOG4105GSQ	TM1410 hypothetical-related protein
THMA_1443	ENOG4108HKT	sucrose-6-phosphate hydrolase
THMA_1444	ENOG4105ECY	inositol monophosphatase
THMA_1446	ENOG4105DIW	FeS assembly protein SUFB
THMA_1447	ENOG4105C3K	feS assembly ATPase SufC
THMA_1448	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THMA_1451	ENOG4105Y5S	NADH ubiquinone oxidoreductase, 24 kD
THMA_1454	ENOG4105GKE	subunit e
THMA_1455	ENOG4107QIZ	NADH dehydrogenase
THMA_1456	ENOG4107QHI	-hydrogenase
THMA_1457	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
THMA_1458	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
THMA_1459	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
THMA_1460	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
THMA_1461	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
THMA_1462	ENOG4107KMQ	bfd domain protein (2fe-2s)-binding domain protein
THMA_1467	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
THMA_1468	ENOG4107RFW	hydrolase family 57
THMA_1470	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
THMA_1471	ENOG4105C9M	aspartyl-trna synthetase
THMA_1472	ENOG41084GC	stage II sporulation protein
THMA_1473	ENOG4107RB4	Cytidine monophosphate kinase
THMA_1474	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
THMA_1475	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
THMA_1476	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
THMA_1477	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
THMA_1480	ENOG4108JA2	transcriptioN-repair coupling factor
THMA_1481	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THMA_1482	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
THMA_1483	ENOG4108UJD	30S ribosomal protein S9
THMA_1484	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
THMA_1485	ENOG41081BK	membrane protein-like protein
THMA_1486	ENOG4105K46	50S ribosomal protein l27
THMA_1488	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
THMA_1491	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
THMA_1492	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
THMA_1493	ENOG41084AH	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
THMA_1494	ENOG41085QA	50S ribosomal protein l34
THMA_1495	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
THMA_1496	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
THMA_1497	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
THMA_1498	ENOG4105DHT	Metal Dependent Phosphohydrolase
THMA_1500	ENOG4105EPR	degv family
THMA_1501	ENOG4105DKQ	ROK family
THMA_1502	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
THMA_1503	ENOG4108ZT0	50S ribosomal protein l17
THMA_1504	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THMA_1505	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
THMA_1506	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
THMA_1507	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THMA_1508	ENOG41086MH	50S ribosomal protein L36
THMA_1509	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
THMA_1511	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
THMA_1512	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
THMA_1513	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
THMA_1514	ENOG4105VPB	50S ribosomal protein L30
THMA_1515	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
THMA_1516	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
THMA_1517	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
THMA_1518	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
THMA_1519	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
THMA_1520	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THMA_1521	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
THMA_1522	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
THMA_1523	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
THMA_1524	ENOG41084ME	50s ribosomal protein l29
THMA_1525	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
THMA_1526	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
THMA_1527	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
THMA_1528	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
THMA_1529	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THMA_1530	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
THMA_1531	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
THMA_1532	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
THMA_1533	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
THMA_1534	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
THMA_1535	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THMA_1536	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
THMA_1537	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
THMA_1539	ENOG4105C9A	Phoh family
THMA_1540	ENOG4105CTJ	Metal Dependent Phosphohydrolase
THMA_1541	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
THMA_1544	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
THMA_1545	ENOG4105CDE	UPF0348 protein
THMA_1548	ENOG4105CH2	amidohydrolase
THMA_1549	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
THMA_1552	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
THMA_1553	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
THMA_1555	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
THMA_1562	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
THMA_1564	ENOG4105BZJ	Electron transfer flavoprotein
THMA_1565	ENOG4105C10	Electron transfer flavoprotein
THMA_1566	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
THMA_1567	ENOG41090P5	ferredoxin-like protein
THMA_1571	ENOG4105EPH	radical SAM domain protein
THMA_1573	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
THMA_1574	ENOG4105TZT	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
THMA_1576	ENOG4105CGA	flagellar basal-body rod protein FlgG
THMA_1577	ENOG4105KTQ	flagellar basal-body rod protein
THMA_1581	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
THMA_1582	ENOG4105DCI	Phosphohydrolase
THMA_1584	ENOG4107UKG	Glycosyl transferase, family 4
THMA_1585	ENOG4105CBJ	Metal-dependent enzyme
THMA_1586	ENOG4105NBF	ammecr1 domain protein
THMA_1588	ENOG4105CJ2	(LipO)protein
THMA_1592	ENOG4105W5Q	DNA repair protein (RadC
THMA_1594	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
THMA_1596	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
THMA_1599	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
THMA_1600	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THMA_1601	ENOG4105K5M	30s ribosomal protein S16
THMA_1602	ENOG41084QK	UPF0109 protein
THMA_1603	ENOG410836E	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
THMA_1604	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
THMA_1605	ENOG4108WTY	tRNA (Guanine-N(1)-)-methyltransferase
THMA_1606	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
THMA_1607	ENOG4105C3F	Signal peptidase i
THMA_1609	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
THMA_1611	ENOG4105DX0	Hemolysin A
THMA_1613	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
THMA_1615	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THMA_1619	ENOG4105MJ2	Competence protein
THMA_1620	ENOG4105D1Z	hydroxypyruvate reductase
THMA_1623	ENOG4105BZU	Histidine kinase
THMA_1630	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
THMA_1633	ENOG4105D1F	ATP-binding protein
THMA_1634	ENOG4105BZU	Histidine kinase
THMA_1635	ENOG4105SFS	phosphoesterase RecJ domain protein
THMA_1636	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
THMA_1638	ENOG4105EMN	RNA polymerase sigma factor
THMA_1641	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THMA_1642	ENOG4108Z3G	3H domain protein
THMA_1643	ENOG41079KZ	Major Facilitator Superfamily
THMA_1644	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
THMA_1646	ENOG4105C03	ribonuclease
THMA_1647	ENOG4105MS2	ribosomal subunit Interface protein
THMA_1648	ENOG4105EPR	degv family
THMA_1649	ENOG41082J0	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THMA_1650	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
THMA_1651	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
THMA_1652	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
THMA_1653	ENOG41085KK	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THMA_1654	ENOG41084Y9	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THMA_1655	ENOG410855G	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THMA_1656	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
THMA_1659	ENOG4108W5Z	CheC domain protein
THMA_1660	ENOG4105C2M	dna polymerase I
THMA_1662	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
THMA_1664	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
THMA_1665	ENOG4105CNT	hydrolase family 2
THMA_1667	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
THMA_1668	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
THMA_1669	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
THMA_1670	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
THMA_1673	ENOG4105K8N	protein family UPF0079, ATPase
THMA_1674	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
THMA_1676	ENOG4107RH8	nuclease SbcCD subunit D
THMA_1677	ENOG4107WZZ	SMC domain protein
THMA_1679	ENOG4108IUW	ABC transporter
THMA_1680	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
THMA_1682	ENOG41084X0	Dihydrofolate reductase
THMA_1683	ENOG4105CXT	aspartate transcarbamylase
THMA_1684	ENOG4108Q27	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)
THMA_1685	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
THMA_1686	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
THMA_1689	ENOG4108WF2	Metal Dependent Phosphohydrolase
THMA_1692	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THMA_1695	ENOG4105BZU	Histidine kinase
THMA_1696	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THMA_1699	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
THMA_1702	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
THMA_1703	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
THMA_1704	ENOG4108JJB	ABC transporter
THMA_1705	ENOG4107Y49	methyltransferase
THMA_1707	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
THMA_1708	ENOG4105C93	Xylose Isomerase
THMA_1714	ENOG4105D00	flagellar biosynthetic protein flhB
THMA_1720	ENOG4105CPI	Metal Dependent Phosphohydrolase
THMA_1724	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMA_1725	ENOG4105VEQ	Cold shock protein
THMA_1726	ENOG41084K4	Binds the 23S rRNA (By similarity)
THMA_1727	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
THMA_1728	ENOG4107Y2H	ErfK ybiS ycfS ynhG family protein
THMA_1729	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
THMA_1731	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
THMA_1732	ENOG4105KC4	UPF0296 protein
THMA_1736	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
THMA_1741	ENOG4108ESY	Metal dependent phosphohydrolase
THMA_1743	ENOG4107QJQ	Mate efflux family protein
THMA_1745	ENOG4105E0M	Sulfatase
THMA_1747	ENOG4105CRK	lysyL-tRNA synthetase
THMA_1748	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
THMA_1749	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
THMA_1750	ENOG4105CIE	May be required for sporulation (By similarity)
THMA_1751	ENOG4105CHW	UPF0052 protein
THMA_1755	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
THMA_1757	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
THMA_1759	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
THMA_1760	ENOG4105DJV	ribulose-phosphate 3-epimerase
THMA_1761	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
THMA_1762	ENOG4108HPG	-acetyltransferase
THMA_1766	ENOG4105CHR	reductase
THMA_1767	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THMA_1770	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
THMA_1772	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
THMA_1773	ENOG4105DFA	alanine racemase domain protein
THMA_1775	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
THMA_1776	ENOG4105QGT	Phosphate uptake regulator
THMA_1778	ENOG4105CDU	Replicative dna helicase
THMA_1779	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
THMA_1782	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
THMA_1783	ENOG4105C2N	RNA methyltransferase TrmH family group 3
THMA_1784	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
THMA_1785	ENOG4108FN7	Aldo keto reductase
THMA_1788	ENOG4107QSI	ABC, transporter
THMA_1789	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMA_1790	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMA_1791	ENOG4105C3U	ABC transporter
THMA_1792	ENOG4108JQ7	(ABC) transporter
THMA_1795	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
THMA_1796	ENOG4105CKM	Branched-chain carboxylic acid kinase
THMA_1797	ENOG4107RE7	phosphate butyryltransferase
THMA_1798	ENOG4105CKM	Branched-chain carboxylic acid kinase
THMA_1805	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
THMA_1807	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
THMA_1809	ENOG4105M7K	Involved in the transcription termination process (By similarity)
THMA_1810	ENOG4105CKU	formyltetrahydrofolate synthetase
THMA_1811	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
THMA_1812	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
THMA_1813	ENOG41087NB	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
THMA_1814	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
THMA_1818	ENOG4105E3H	phosphoglycerate mutase
THMA_1820	ENOG4105I3K	Ferric uptake regulator, Fur family
THMA_1821	ENOG4105CHV	Transcription elongation factor NusA
THMA_1822	ENOG4108396	Required for maturation of 30S ribosomal subunits (By similarity)
THMA_1824	ENOG4105CDH	Citrulline--aspartate ligase
THMA_1825	ENOG4105CH7	arginosuccinase
THMA_1826	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
THMA_1827	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
THMA_1828	ENOG4105CAS	nag kinase
THMA_1829	ENOG4105C8Y	Acetylornithine aminotransferase
THMA_1833	ENOG4105BZU	Histidine kinase
THMA_1842	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
THMA_1843	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
THMA_1849	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
THMA_1853	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
THMA_1855	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
THMA_1857	ENOG410695F	Crispr-associated protein, Csm1 family
THMA_1862	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
THMA_1863	ENOG4105FGV	Chromate
THMA_1866	ENOG4105GRF	N-glycosylase DNA lyase
THMA_1867	ENOG4107QJR	hflk protein
THMA_1868	ENOG4105EPW	hflc protein
THMA_1871	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
THMA_1872	ENOG4108R6K	riboflavin synthase, subunit alpha
THMA_1873	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
THMA_1874	ENOG4105BZU	Histidine kinase
THMA_1877	ENOG4108T5G	Adenylate
THMA_1878	ENOG4107V4V	glycoside hydrolase family 4
THMA_1879	ENOG4108IUK	alpha amylase, catalytic
THMA_1881	ENOG4105D56	permease protein
THMA_1882	ENOG4107FKK	extracellular solute-binding protein family 1
THMA_1883	ENOG4105CG3	alpha amylase, catalytic region
THMA_1888	ENOG4108IUM	Glycogen debranching enzyme
THMA_1890	ENOG4105E2R	ROK family
THMA_1892	ENOG4105CNN	ABC, transporter
THMA_1893	ENOG4105D4B	ABC, transporter
THMA_1896	ENOG4107T3P	ABC, transporter
THMA_1898	ENOG4105E2V	Glycosyltransferase 36
THMA_1903	ENOG4105DRS	transport system, permease
THMA_1904	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
THMA_1906	ENOG4105ETE	Transcriptional regulator (LacI family
THMA_1907	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
THMA_1909	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
THMA_1910	ENOG41081HM	2'-5' rna ligase
THMA_1911	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THMA_1912	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THMA_1915	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
THMA_1917	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
THMA_1918	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
THMA_1919	ENOG4105DAN	ATP-dependent protease
THMA_1920	ENOG4107U53	septum site-determining protein minD
THMA_1922	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
THMA_1924	ENOG4105VEQ	Cold shock protein
THMA_1925	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
THMA_1926	ENOG4108RE9	Phosphodiesterase
THMA_1928	ENOG4105CGH	5'-nucleotidase