locus-tag	class	description
THMC_0002	ENOG4105DTQ	mandelate racemase muconate lactonizing
THMC_0004	ENOG4106IPI	cyclase, family
THMC_0006	ENOG4107QIZ	NADH dehydrogenase
THMC_0008	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
THMC_0010	ENOG4105C8Q	Methyl-accepting chemotaxis
THMC_0011	ENOG4105EJ5	oxidoreductase gamma subunit
THMC_0012	ENOG4105WGB	oxidoreductase, delta subunit
THMC_0013	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
THMC_0014	ENOG4105DDK	oxidoreductase, beta subunit
THMC_0015	ENOG4107EXU	Short-chain dehydrogenase reductase Sdr
THMC_0016	ENOG4105WMR	Protein CrcB homolog
THMC_0017	ENOG4105KJJ	Uncharacterized ACR, COG1993
THMC_0018	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
THMC_0019	ENOG4105C8Q	Methyl-accepting chemotaxis
THMC_0021	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
THMC_0023	ENOG4108JQ7	(ABC) transporter
THMC_0027	ENOG4108J59	Extracellular solute-binding protein, family 5
THMC_0032	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
THMC_0033	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMC_0034	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
THMC_0035	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
THMC_0037	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THMC_0038	ENOG4105DC7	peptidase M24
THMC_0039	ENOG4105BZ1	(ABC) transporter
THMC_0043	ENOG4105D7V	transposase
THMC_0047	ENOG4105CE1	Ferrous iron transport protein b
THMC_0051	ENOG4105D0H	Alpha-glucuronidase (EC 3.2.1.139)
THMC_0053	ENOG4108JQ7	(ABC) transporter
THMC_0054	ENOG4105C3U	ABC transporter
THMC_0055	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_0056	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMC_0057	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
THMC_0060	ENOG4105D2H	Uronic isomerase
THMC_0061	ENOG4107258	Transcriptional regulator
THMC_0062	ENOG4108UHU	Aldolase
THMC_0064	ENOG4105DEI	Mannitol dehydrogenase
THMC_0065	ENOG4105CHZ	Catalyzes the dehydration of D-mannonate (By similarity)
THMC_0066	ENOG4105D9F	endo-1,4-beta-xylanase (EC 3.2.1.8)
THMC_0068	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMC_0069	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_0070	ENOG4105C3U	ABC transporter
THMC_0071	ENOG4108JQ7	(ABC) transporter
THMC_0072	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
THMC_0073	ENOG4105I82	acetyl xylan esterase
THMC_0074	ENOG4105E0A	ABC, transporter
THMC_0075	ENOG4105EHG	Permease protein
THMC_0076	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
THMC_0077	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
THMC_0078	ENOG4105DTJ	flagellar hook-associated protein
THMC_0082	ENOG4105CJR	Integral membrane protein (MviN
THMC_0083	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
THMC_0091	ENOG4105FBB	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity)
THMC_0092	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
THMC_0093	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
THMC_0094	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMC_0096	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
THMC_0098	ENOG4105DIH	basic membrane
THMC_0099	ENOG4108JQ9	ABC transporter
THMC_0100	ENOG4105UIB	(ABC) transporter
THMC_0104	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
THMC_0106	ENOG4105E2R	ROK family
THMC_0108	ENOG4105CNN	ABC, transporter
THMC_0111	ENOG4105C2J	ABC transporter
THMC_0112	ENOG4105CMG	Carbohydrate kinase
THMC_0116	ENOG4108TVJ	Nitroreductase
THMC_0117	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
THMC_0119	ENOG4107XSR	periplasmic solute binding protein
THMC_0120	ENOG4105FDK	ABC transporter
THMC_0121	ENOG41080V6	ABC-3 protein
THMC_0122	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
THMC_0124	ENOG4107QSA	Oxaloacetate decarboxylase
THMC_0127	ENOG4105I03	Flagellin
THMC_0128	ENOG4108W2Y	isochorismatase
THMC_0129	ENOG4105C3M	thioredoxin reductase
THMC_0131	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
THMC_0132	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
THMC_0133	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THMC_0134	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
THMC_0135	ENOG4105DK0	Indole-3-glycerol phosphate synthase
THMC_0136	ENOG4105DDQ	anthranilate synthase
THMC_0137	ENOG4105CRQ	synthase (Component I)
THMC_0138	ENOG4105BZU	Histidine kinase
THMC_0141	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THMC_0142	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
THMC_0143	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
THMC_0144	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
THMC_0145	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
THMC_0146	ENOG41085U1	50S ribosomal protein L32
THMC_0150	ENOG4105CQC	Prephenate dehydratase
THMC_0151	ENOG4105G6Z	alkaline phosphatase
THMC_0154	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
THMC_0155	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
THMC_0161	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
THMC_0162	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
THMC_0163	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
THMC_0164	ENOG4105C8T	Leucyl-tRNA synthetase
THMC_0165	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
THMC_0167	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
THMC_0168	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
THMC_0169	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
THMC_0170	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THMC_0171	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
THMC_0174	ENOG4105C25	Primosomal protein n'
THMC_0183	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THMC_0184	ENOG4105C4K	Nad synthetase
THMC_0185	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
THMC_0187	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMC_0188	ENOG4105BZU	Histidine kinase
THMC_0191	ENOG4105S10	periplasmic binding protein
THMC_0192	ENOG4108ESU	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)
THMC_0193	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
THMC_0194	ENOG4105MCT	stage V sporulation protein S
THMC_0199	ENOG4105C4B	ABC transporter, permease
THMC_0200	ENOG4108T5I	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THMC_0204	ENOG4107R56	PP-loop domain protein
THMC_0205	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THMC_0206	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
THMC_0207	ENOG4105E59	Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)
THMC_0208	ENOG4107QHI	-hydrogenase
THMC_0213	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
THMC_0214	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
THMC_0215	ENOG4105CA9	Pyruvate kinase
THMC_0216	ENOG4105CTQ	phosphohexokinase
THMC_0218	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
THMC_0219	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
THMC_0220	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMC_0221	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMC_0222	ENOG4105KME	endoribonuclease L-psp
THMC_0223	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
THMC_0224	ENOG4107RFA	Glycyl-tRNA synthetase beta subunit
THMC_0226	ENOG4105W2B	Flagellar assembly protein
THMC_0227	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
THMC_0228	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
THMC_0229	ENOG4108JJB	ABC transporter
THMC_0231	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
THMC_0232	ENOG4105K6H	D-cysteine desulfhydrase
THMC_0234	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
THMC_0235	ENOG4107QIZ	NADH dehydrogenase
THMC_0238	ENOG4105DFU	Cell wall formation (By similarity)
THMC_0239	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
THMC_0240	ENOG4105CNI	cell division protein FtsW
THMC_0241	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
THMC_0242	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
THMC_0243	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
THMC_0244	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
THMC_0246	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
THMC_0247	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
THMC_0250	ENOG4107QSQ	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
THMC_0251	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
THMC_0252	ENOG4105D6A	Electron transport complex
THMC_0254	ENOG4105DZB	Electron transport complex
THMC_0256	ENOG4107SVV	electron transport complex, RnfABCDGE type, B subunit
THMC_0257	ENOG4105C79	DNA protecting protein DprA
THMC_0258	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
THMC_0259	ENOG41084A9	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THMC_0260	ENOG41085R6	UPF0102 protein
THMC_0261	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
THMC_0262	ENOG4105VB9	50S ribosomal protein l28
THMC_0264	ENOG4105EQI	Metal Dependent Phosphohydrolase
THMC_0265	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
THMC_0266	ENOG4105CPF	Cell wall formation (By similarity)
THMC_0268	ENOG4105CJ3	phosphate transporter
THMC_0269	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
THMC_0270	ENOG4105CWE	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
THMC_0271	ENOG4105I08	Pseudouridine synthase
THMC_0272	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
THMC_0273	ENOG4105K70	DNA-binding protein
THMC_0274	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
THMC_0275	ENOG4105C3R	Methionine synthase
THMC_0279	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
THMC_0280	ENOG4105D2N	Aldolase
THMC_0281	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
THMC_0283	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
THMC_0286	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
THMC_0288	ENOG4105CZZ	Alpha-N-arabinofuranosidase (EC 3.2.1.55)
THMC_0289	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
THMC_0290	ENOG4105CR5	Class II aldolase adducin family protein
THMC_0291	ENOG4105CMG	Carbohydrate kinase
THMC_0292	ENOG4108MDK	Dehydrogenase
THMC_0294	ENOG4105BZ1	(ABC) transporter
THMC_0295	ENOG4105BZ1	(ABC) transporter
THMC_0296	ENOG4107UUY	ec 2.7.1.11
THMC_0297	ENOG4105BZN	citrate synthase
THMC_0298	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMC_0299	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMC_0300	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
THMC_0301	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
THMC_0302	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
THMC_0303	ENOG4105D7K	pfkb domain protein
THMC_0304	ENOG4105CHR	reductase
THMC_0305	ENOG4105CPQ	Dehydrogenase
THMC_0306	ENOG4105ETE	Transcriptional regulator (LacI family
THMC_0308	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMC_0309	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_0310	ENOG4108JQ7	(ABC) transporter
THMC_0315	ENOG4105CJQ	hydrolase, family 31
THMC_0319	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
THMC_0320	ENOG4105CPC	Aldo Keto reductase
THMC_0324	ENOG4105C59	p-type ATPase
THMC_0325	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
THMC_0329	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
THMC_0331	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
THMC_0332	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
THMC_0333	ENOG4106KNT	transcriptional regulator
THMC_0334	ENOG4108JQ1	Dehydrogenase
THMC_0338	ENOG4105EFZ	amidohydrolase
THMC_0339	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
THMC_0340	ENOG4107YPM	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
THMC_0341	ENOG4107W93	Dihydroorotate dehydrogenase
THMC_0342	ENOG4105I47	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
THMC_0343	ENOG4107VJ5	dihydroorotase
THMC_0344	ENOG4105F6J	Alpha beta hydrolase fold
THMC_0345	ENOG4105CCT	upf0313 protein
THMC_0351	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
THMC_0353	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
THMC_0354	ENOG4108237	shikimate dehydrogenase
THMC_0355	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
THMC_0356	ENOG4105D49	3-dehydroquinate synthase
THMC_0357	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
THMC_0359	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THMC_0360	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
THMC_0361	ENOG410624X	efflux transporter, rnd family, mfp subunit
THMC_0364	ENOG4105C7B	Threonine dehydratase
THMC_0366	ENOG4105CBD	Diacylglycerol kinase
THMC_0368	ENOG4105DXN	mazG family
THMC_0370	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
THMC_0371	ENOG4105F23	Fibronectin-binding protein
THMC_0372	ENOG4105CG3	alpha amylase, catalytic region
THMC_0373	ENOG4105DFM	M18 family aminopeptidase
THMC_0374	ENOG4105CSM	endonuclease III
THMC_0378	ENOG4105EHU	Circadian clock protein KaiC
THMC_0379	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
THMC_0381	ENOG4105CFG	Acts as a chaperone (By similarity)
THMC_0382	ENOG4105VN1	Heat shock protein
THMC_0383	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
THMC_0384	ENOG4105EJ9	Membrane
THMC_0385	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
THMC_0386	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
THMC_0389	ENOG4105CEN	a g-specific adenine glycosylase
THMC_0390	ENOG4108TVJ	Nitroreductase
THMC_0392	ENOG4105CJD	(Anaerobic) ribonucleoside-triphosphate reductase
THMC_0393	ENOG4108TVJ	Nitroreductase
THMC_0396	ENOG4105CJ1	ABC, transporter
THMC_0397	ENOG41088YS	Glycosyl transferase (Group 1
THMC_0401	ENOG4105BZ8	glutamate synthase
THMC_0402	ENOG4105CBC	glutamate synthase
THMC_0403	ENOG4105EYU	Glutamine amido-transferase
THMC_0406	ENOG41062D9	Histidine kinase
THMC_0407	ENOG4107104	thymidine kinase
THMC_0409	ENOG4108YZA	Nitrogen regulatory protein pii
THMC_0411	ENOG4105DQU	oxidoreductase, subunit beta
THMC_0414	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
THMC_0415	ENOG4105DR5	peptidase
THMC_0418	ENOG4105CPQ	Dehydrogenase
THMC_0419	ENOG4107W9I	Creatinine amidohydrolase
THMC_0420	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
THMC_0422	ENOG4107S8A	protein TIM barrel
THMC_0425	ENOG4105D56	permease protein
THMC_0426	ENOG4105EG2	ABC transporter, permease
THMC_0429	ENOG4105DCT	glycerol dehydrogenase
THMC_0434	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
THMC_0435	ENOG4105C8Q	Methyl-accepting chemotaxis
THMC_0436	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
THMC_0439	ENOG4105DBA	pectate lyase
THMC_0440	ENOG4107V4V	glycoside hydrolase family 4
THMC_0444	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
THMC_0445	ENOG4108WYP	Transcriptional regulator
THMC_0447	ENOG4105CHR	reductase
THMC_0449	ENOG4105CMG	Carbohydrate kinase
THMC_0450	ENOG4108IJ0	Aspartate ammonia-lyase
THMC_0451	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
THMC_0452	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
THMC_0453	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
THMC_0454	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMC_0455	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
THMC_0460	ENOG41086IP	50S ribosomal protein L33
THMC_0462	ENOG410683Z	Preprotein translocase SecE subunit
THMC_0463	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
THMC_0464	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
THMC_0465	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
THMC_0466	ENOG41081WB	50s ribosomal protein L10
THMC_0467	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
THMC_0468	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THMC_0469	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THMC_0471	ENOG4105C0B	DNA polymerase III (alpha subunit)
THMC_0472	ENOG4105C34	Pseudouridine synthase
THMC_0473	ENOG4105BZU	Histidine kinase
THMC_0475	ENOG4105CDY	transcriptional regulatory protein
THMC_0477	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
THMC_0481	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
THMC_0482	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
THMC_0484	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
THMC_0487	ENOG4105QZY	s-layer domain protein
THMC_0488	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
THMC_0490	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
THMC_0496	ENOG4108IY8	ABC, transporter
THMC_0498	ENOG4105EUS	Binding-protein-dependent transport systems, inner membrane component
THMC_0500	ENOG4105VG1	fes assembly suf system protein
THMC_0501	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
THMC_0503	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
THMC_0505	ENOG4105C31	Tryptophanyl-tRNA synthetase
THMC_0506	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
THMC_0507	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
THMC_0508	ENOG4108IAB	Phoh family
THMC_0509	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
THMC_0513	ENOG4108JQ7	(ABC) transporter
THMC_0514	ENOG4105C3U	ABC transporter
THMC_0515	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_0517	ENOG41083C3	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
THMC_0518	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
THMC_0520	ENOG4105D1H	recombination factor protein RarA
THMC_0523	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
THMC_0525	ENOG4105C0P	Mg chelatase subunit ChlI
THMC_0526	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
THMC_0527	ENOG4105N5T	Radical SAM Protein
THMC_0532	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
THMC_0533	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
THMC_0534	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
THMC_0538	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
THMC_0539	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
THMC_0540	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
THMC_0541	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
THMC_0542	ENOG410681U	heavy metal transport detoxification protein
THMC_0543	ENOG4108JQ7	(ABC) transporter
THMC_0546	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_0547	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THMC_0550	ENOG4106D4I	domain protein
THMC_0551	ENOG4105PGM	cation diffusion facilitator family transporter
THMC_0552	ENOG4108JEB	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
THMC_0554	ENOG4107GFK	fumarate
THMC_0557	ENOG4105CJ1	ABC, transporter
THMC_0558	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
THMC_0559	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
THMC_0560	ENOG4105CFH	Aspartokinase
THMC_0561	ENOG4105C7K	acetolactate synthase
THMC_0563	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
THMC_0564	ENOG4105C01	Dihydroxy-acid dehydratase
THMC_0565	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
THMC_0566	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
THMC_0567	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMC_0568	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
THMC_0569	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
THMC_0570	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
THMC_0571	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
THMC_0574	ENOG4105D7N	magnesium and cobalt transport protein CorA
THMC_0579	ENOG4107ZMQ	sugar fermentation stimulation protein
THMC_0581	ENOG4107YXA	Transcriptional regulator, BadM Rrf2 family
THMC_0584	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
THMC_0585	ENOG4105C0H	protease
THMC_0586	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
THMC_0587	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
THMC_0588	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
THMC_0589	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
THMC_0590	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
THMC_0591	ENOG41080E2	ribosomal-protein-alanine acetyltransferase
THMC_0592	ENOG4105II7	pyrroline-5-carboxylate reductase
THMC_0594	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
THMC_0595	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
THMC_0598	ENOG4107QQG	Dehydrogenase
THMC_0601	ENOG410631K	Membrane
THMC_0602	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
THMC_0603	ENOG4105DFF	Rod shape-determining protein mreb
THMC_0606	ENOG4105CJN	penicillin-binding protein
THMC_0608	ENOG4105E5Q	amino acid AbC transporter
THMC_0609	ENOG4105EAB	amino acid AbC transporter
THMC_0610	ENOG4105C7N	Xanthine uracil vitamin C permease
THMC_0614	ENOG4105DRS	transport system, permease
THMC_0619	ENOG41083EQ	Binds together with S18 to 16S ribosomal RNA (By similarity)
THMC_0620	ENOG4108UUM	single-stranded DNA-binding protein
THMC_0621	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
THMC_0623	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THMC_0626	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
THMC_0635	ENOG4107RA4	Glycosyl transferase (Group 1
THMC_0638	ENOG4107STW	synthase
THMC_0640	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
THMC_0643	ENOG4107SBE	Glycosyl transferase (Group 1
THMC_0646	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
THMC_0649	ENOG4108ZW7	flagellar rod assembly protein muramidase flgj
THMC_0654	ENOG4105DAY	polysaccharide export protein
THMC_0660	ENOG4107S7H	nh(3)-dependent nad( ) synthetase
THMC_0662	ENOG41082Q0	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
THMC_0666	ENOG4105J7I	hydrolase
THMC_0668	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THMC_0669	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
THMC_0670	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
THMC_0671	ENOG4106A7E	Transcriptional regulator
THMC_0672	ENOG4108RAC	Rubrerythrin
THMC_0673	ENOG4108YZ8	Superoxide reductase
THMC_0674	ENOG4105VCQ	rubredoxin
THMC_0675	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
THMC_0677	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
THMC_0680	ENOG4105C6T	cysteine synthase
THMC_0681	ENOG4105D7W	serine acetyltransferase
THMC_0682	ENOG4105F8V	Hydrolase, tatD family
THMC_0689	ENOG4105BZE	flagellar hook protein, FlgE
THMC_0690	ENOG41068WV	flagellar FlbD family protein
THMC_0691	ENOG4105E14	MotA TolQ exbB proton channel
THMC_0692	ENOG4105ER2	Ompa motb domain protein
THMC_0694	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
THMC_0695	ENOG4105DD5	Flagellar motor switch protein
THMC_0701	ENOG4105C6E	dna polymerase iii
THMC_0702	ENOG41085TI	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
THMC_0703	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
THMC_0704	ENOG4105BZA	Phosphoglycerate kinase
THMC_0707	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
THMC_0709	ENOG4107XYV	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase (By similarity)
THMC_0710	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
THMC_0713	ENOG4105CN7	Flagellar biosynthetic protein FliP
THMC_0715	ENOG4107YTP	response regulator receiver protein
THMC_0716	ENOG4105YVF	chew protein
THMC_0717	ENOG4105CBS	Chea signal transduction histidine kinase
THMC_0718	ENOG4105CEV	competence damage-inducible protein
THMC_0719	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THMC_0720	ENOG4105C19	ABC transporter
THMC_0722	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
THMC_0723	ENOG4107S5Z	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity)
THMC_0724	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
THMC_0731	ENOG4105D8K	carboxyl transferase
THMC_0733	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
THMC_0734	ENOG4105YFD	chemotaxis, protein
THMC_0735	ENOG4105C8N	cysteinyl-tRNA synthetase
THMC_0736	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
THMC_0737	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
THMC_0738	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
THMC_0742	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
THMC_0743	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
THMC_0747	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
THMC_0748	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
THMC_0749	ENOG4105WPN	DNA integration recombination invertion protein
THMC_0752	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
THMC_0754	ENOG4105DG6	mannose-6-phosphate isomerase
THMC_0757	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMC_0758	ENOG4105C22	threonyL-tRNA synthetase
THMC_0759	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
THMC_0760	ENOG4107S1Q	Phosphatase
THMC_0762	ENOG4105BZF	Glycosyl transferase (Group 1
THMC_0765	ENOG4105CN1	protease
THMC_0766	ENOG4105E26	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)
THMC_0769	ENOG4105C22	threonyL-tRNA synthetase
THMC_0771	ENOG4107V4V	glycoside hydrolase family 4
THMC_0772	ENOG4107UA9	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
THMC_0774	ENOG4105CNW	domain protein
THMC_0775	ENOG4105K64	Glycosyl transferase, family 2
THMC_0776	ENOG4107TVC	Glycosyl transferase, family 2
THMC_0781	ENOG4105CE9	30S ribosomal protein S2
THMC_0782	ENOG4105K8R	UPF0145 protein
THMC_0784	ENOG4105CJ1	ABC, transporter
THMC_0786	ENOG4105C9C	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)
THMC_0787	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
THMC_0789	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THMC_0790	ENOG4107QRG	dna polymerase iii
THMC_0791	ENOG4105MA4	psp1 domain protein
THMC_0792	ENOG41061AI	Protein of unknown function (DUF2905)
THMC_0794	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
THMC_0804	ENOG41074CX	linocin_m18 bacteriocin protein
THMC_0806	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
THMC_0807	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
THMC_0809	ENOG4107ZCS	Phosphomethylpyrimidine kinase
THMC_0810	ENOG410816Z	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)
THMC_0812	ENOG4105CJ1	ABC, transporter
THMC_0816	ENOG4108N5B	2-phosphosulfolactate phosphatase
THMC_0818	ENOG4105VKD	bioY protein
THMC_0819	ENOG4105EA8	2-Nitropropane dioxygenase
THMC_0820	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
THMC_0821	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
THMC_0822	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
THMC_0823	ENOG4107RU2	Histidinol phosphate phosphatase, HisJ family
THMC_0824	ENOG4105ESV	Glycosyl transferase, family 4
THMC_0826	ENOG4105D3R	alkyl hydroperoxide reductase
THMC_0827	ENOG4105E2R	ROK family
THMC_0831	ENOG4105DRS	transport system, permease
THMC_0832	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
THMC_0833	ENOG4105CE4	GlcNAc 6-P deacetylase
THMC_0834	ENOG4105UQX	Mate efflux family protein
THMC_0838	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
THMC_0840	ENOG4107QW4	alcohol dehydrogenase
THMC_0842	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
THMC_0843	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
THMC_0844	ENOG4108IG5	Transcriptional regulator
THMC_0846	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
THMC_0848	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
THMC_0849	ENOG4105DE4	1-phosphofructokinase
THMC_0851	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
THMC_0852	ENOG4107Z5F	Aminotransferase class IV
THMC_0854	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THMC_0856	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
THMC_0857	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
THMC_0858	ENOG4107QHF	type ii secretion system protein e
THMC_0860	ENOG4105CNI	cell division protein FtsW
THMC_0863	ENOG4107YTP	response regulator receiver protein
THMC_0864	ENOG4105CCS	Glutamate formiminotransferase
THMC_0865	ENOG41082VF	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
THMC_0866	ENOG4108JU5	Magnesium and cobalt efflux protein
THMC_0867	ENOG4105KG3	cytidine deaminase
THMC_0868	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
THMC_0869	ENOG4105CQW	ribosome biogenesis GTPase YqeH
THMC_0870	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
THMC_0871	ENOG41085Z1	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THMC_0872	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
THMC_0874	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
THMC_0875	ENOG4105BZU	Histidine kinase
THMC_0876	ENOG4108HU6	Metal dependent phosphohydrolase
THMC_0877	ENOG41084NJ	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
THMC_0878	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
THMC_0879	ENOG4105DTN	riboflavin biosynthesis protein ribF
THMC_0881	ENOG4107Z7W	Preprotein translocase YajC subunit
THMC_0882	ENOG4107QN8	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THMC_0883	ENOG4107VRQ	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
THMC_0884	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
THMC_0885	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
THMC_0886	ENOG4105IES	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)
THMC_0890	ENOG4108JU3	Alkyl hydroperoxide reductase
THMC_0892	ENOG4105CJN	penicillin-binding protein
THMC_0894	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
THMC_0895	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THMC_0899	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
THMC_0900	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
THMC_0902	ENOG4105D9Q	decarboxylase (Beta subunit)
THMC_0903	ENOG4105CVG	Homoserine O-transsuccinylase
THMC_0905	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
THMC_0908	ENOG4105BZ4	penicillin-binding protein
THMC_0909	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
THMC_0911	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
THMC_0912	ENOG4105DZP	Membrane-associated zinc metalloprotease
THMC_0913	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
THMC_0914	ENOG4105CJW	magnesium transporter
THMC_0915	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
THMC_0917	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
THMC_0918	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
THMC_0919	ENOG4105MCT	stage V sporulation protein S
THMC_0924	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THMC_0925	ENOG4108Z4W	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)
THMC_0926	ENOG4107PHP	CheC --inhibitor of MCP methylation
THMC_0929	ENOG4105FZW	flagellar biosynthesis regulator FlhF
THMC_0930	ENOG4105D7B	Flagellar biosynthesis protein flha
THMC_0931	ENOG4105D00	flagellar biosynthetic protein flhB
THMC_0932	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
THMC_0933	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
THMC_0935	ENOG4105DXN	mazG family
THMC_0936	ENOG41080JC	Protein of unknown function DUF47
THMC_0937	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
THMC_0939	ENOG4105CJ3	phosphate transporter
THMC_0940	ENOG4105C8Q	Methyl-accepting chemotaxis
THMC_0944	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
THMC_0947	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
THMC_0948	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
THMC_0949	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
THMC_0950	ENOG41063SX	
THMC_0951	ENOG4105EZM	VWA-like domain (DUF2201)
THMC_0956	ENOG4107R3E	Citrate transporter
THMC_0957	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMC_0958	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
THMC_0961	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
THMC_0962	ENOG4105EI2	Pseudouridine synthase
THMC_0966	ENOG4105C5F	glutamine synthetase
THMC_0975	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
THMC_0976	ENOG4108IUS	Transketolase
THMC_0977	ENOG4108HHA	Transketolase
THMC_0978	ENOG4105CNN	ABC, transporter
THMC_0979	ENOG4105C2J	ABC transporter
THMC_0981	ENOG4105E9V	Periplasmic binding protein LacI transcriptional regulator
THMC_0982	ENOG4105MRB	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity)
THMC_0983	ENOG4108RVA	ribokinase
THMC_0984	ENOG4108V0P	LemA family
THMC_0987	ENOG4108086	Protein of unknown function DUF111
THMC_0988	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
THMC_0990	ENOG4108I7H	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
THMC_0995	ENOG4105BZU	Histidine kinase
THMC_0996	ENOG4105C8Q	Methyl-accepting chemotaxis
THMC_1000	ENOG41084XP	SirA-like domain-containing protein
THMC_1004	ENOG4105CUC	YeeE YedE family protein
THMC_1005	ENOG41084XP	SirA-like domain-containing protein
THMC_1006	ENOG4107S85	alpha-2-macroglobulin domain protein
THMC_1008	ENOG4108QJJ	Protein of unknown function (DUF1175)
THMC_1012	ENOG4105C0D	helicase
THMC_1020	ENOG41080HT	Transcriptional regulator, arsr family
THMC_1022	ENOG41060KZ	Hepn domain protein
THMC_1028	ENOG4105CF7	AraC family transcriptional regulator
THMC_1029	ENOG4107SET	aldo keto reductase
THMC_1031	ENOG4105CV8	reductase
THMC_1037	ENOG4105D82	Glutamate dehydrogenase
THMC_1042	ENOG4107RCC	Major Facilitator Superfamily
THMC_1050	ENOG4105CIG	ABC transporter
THMC_1055	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
THMC_1056	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
THMC_1057	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
THMC_1058	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
THMC_1059	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
THMC_1060	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
THMC_1061	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
THMC_1062	ENOG4105CIH	Imidazole acetol-phosphate transaminase
THMC_1063	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
THMC_1064	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
THMC_1066	ENOG4105D7V	transposase
THMC_1067	ENOG4108J9M	Transporter
THMC_1069	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
THMC_1070	ENOG4105CN9	Peptidase m42 family protein
THMC_1071	ENOG4105CN9	Peptidase m42 family protein
THMC_1072	ENOG4105CN9	Peptidase m42 family protein
THMC_1074	ENOG4105KQC	Competence protein
THMC_1076	ENOG4108IUZ	ABC transporter
THMC_1078	ENOG4108531	cuta1 divalent ion tolerance protein
THMC_1079	ENOG4107SVH	Potassium channel protein
THMC_1081	ENOG4105MCT	stage V sporulation protein S
THMC_1084	ENOG4105CNT	hydrolase family 2
THMC_1085	ENOG4108JQ7	(ABC) transporter
THMC_1086	ENOG4105C3U	ABC transporter
THMC_1087	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_1088	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMC_1090	ENOG4107V4V	glycoside hydrolase family 4
THMC_1091	ENOG4105E98	transcriptional regulator DeoR family
THMC_1093	ENOG4105C9F	isomerase
THMC_1095	ENOG4105DET	Rhamnulokinase
THMC_1099	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
THMC_1101	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
THMC_1102	ENOG4108YZG	isomerase
THMC_1103	ENOG410682B	stage II sporulation protein
THMC_1104	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
THMC_1105	ENOG4106FU4	Archease protein family (MTH1598/TM1083)
THMC_1106	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
THMC_1107	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
THMC_1110	ENOG4107VEG	TrkA-N domain protein
THMC_1112	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
THMC_1113	ENOG4105CUT	histidyl-tRNA synthetase
THMC_1116	ENOG4105C75	arginyL-tRNA synthetase
THMC_1117	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
THMC_1118	ENOG4105C83	adenylosuccinate lyase
THMC_1119	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
THMC_1120	ENOG4105DBV	ornithine carbamoyltransferase
THMC_1122	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
THMC_1124	ENOG4108RE9	Phosphodiesterase
THMC_1125	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
THMC_1128	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THMC_1143	ENOG4105BZ7	extracellular solute-binding protein family 1
THMC_1146	ENOG4107V1F	Flagellar hook-associated 2 domain-containing protein
THMC_1152	ENOG41083B7	nucleosidase (EC 3.2.2.9)
THMC_1153	ENOG4107RE7	phosphate butyryltransferase
THMC_1154	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
THMC_1155	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
THMC_1159	ENOG4105C32	Amino acid ABC transporter (Permease)
THMC_1160	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
THMC_1161	ENOG4105C0Z	ABC transporter
THMC_1162	ENOG4108IV0	ABC, transporter
THMC_1163	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMC_1164	ENOG4107QIV	Cytochrome c biogenesis protein
THMC_1166	ENOG4105C8Q	Methyl-accepting chemotaxis
THMC_1168	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMC_1170	ENOG4105C8Q	Methyl-accepting chemotaxis
THMC_1171	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMC_1173	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMC_1174	ENOG4105DEF	Extracellular solute-binding protein, family 5
THMC_1175	ENOG4108JQ7	(ABC) transporter
THMC_1177	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_1178	ENOG4108Q79	6-phosphogluconolactonase (EC 3.1.1.31)
THMC_1179	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
THMC_1180	ENOG41067S9	phage shock protein C, PspC
THMC_1186	ENOG4105CJW	magnesium transporter
THMC_1187	ENOG4105E8R	UPF0173 metal-dependent hydrolase
THMC_1188	ENOG4108KHP	Diguanylate cyclase
THMC_1190	ENOG4105DQU	oxidoreductase, subunit beta
THMC_1191	ENOG4105CSA	Coproporphyrinogen iii oxidase
THMC_1193	ENOG4107R76	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)
THMC_1194	ENOG4105CHR	reductase
THMC_1195	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMC_1197	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
THMC_1202	ENOG4107VXZ	Hydrolase
THMC_1203	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
THMC_1204	ENOG4105MQ3	flagellar protein FliS
THMC_1206	ENOG4108YZ4	nudix hydrolase
THMC_1207	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
THMC_1208	ENOG4107SET	aldo keto reductase
THMC_1209	ENOG4105BZU	Histidine kinase
THMC_1210	ENOG4108Z5K	methylglyoxal synthase
THMC_1212	ENOG4107WSY	Domain of unknown function DUF20
THMC_1216	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
THMC_1217	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
THMC_1218	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
THMC_1219	ENOG4105CNT	hydrolase family 2
THMC_1222	ENOG4108JQ7	(ABC) transporter
THMC_1223	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_1226	ENOG4105ETE	Transcriptional regulator (LacI family
THMC_1228	ENOG4105EG2	ABC transporter, permease
THMC_1229	ENOG4105D56	permease protein
THMC_1230	ENOG4107FKK	extracellular solute-binding protein family 1
THMC_1231	ENOG4105SC1	monovalent cation H antiporter subunit E
THMC_1232	ENOG410684G	monovalent cation H antiporter subunit F
THMC_1235	ENOG4105D65	subunit l
THMC_1237	ENOG4108JPZ	Monovalent cation H antiporter subunit D
THMC_1240	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THMC_1241	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THMC_1242	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
THMC_1244	ENOG4105ETE	Transcriptional regulator (LacI family
THMC_1245	ENOG4108JQ7	(ABC) transporter
THMC_1247	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_1248	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMC_1249	ENOG4108J59	Extracellular solute-binding protein, family 5
THMC_1250	ENOG4105E2R	ROK family
THMC_1251	ENOG4105CKB	glycosidase
THMC_1252	ENOG4107QRA	Extracellular solute-binding protein, family 5
THMC_1255	ENOG4106J7S	Glycosyl transferase, family 2
THMC_1256	ENOG4105IRK	Glycosyl transferase (Group 1
THMC_1257	ENOG4105C8I	hydrolase, family 38
THMC_1258	ENOG4108IJ9	(ABC) transporter
THMC_1263	ENOG4105C4R	Atp-dependent dna helicase
THMC_1265	ENOG4105C3G	gtp-binding protein
THMC_1268	ENOG4105C8V	SAICAR synthetase
THMC_1269	ENOG4108A1T	Phosphoribosylformylglycinamidine synthase, purS
THMC_1270	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
THMC_1271	ENOG4108JIU	phosphoribosylformylglycinamidine synthase ii
THMC_1273	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
THMC_1274	ENOG4105DC1	bifunctional purine biosynthesis protein purh
THMC_1275	ENOG4107QNG	Phosphoribosylglycinamide synthetase
THMC_1278	ENOG4105C4K	Nad synthetase
THMC_1279	ENOG4105MN5	HAD-superfamily hydrolase subfamily IA variant 3
THMC_1280	ENOG4105CHM	Aminotransferase
THMC_1281	ENOG4105BZ1	(ABC) transporter
THMC_1284	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THMC_1285	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
THMC_1286	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
THMC_1289	ENOG4105CVA	phosphate
THMC_1294	ENOG4107QW8	radical SAM domain protein
THMC_1295	ENOG4105C28	cystathionine
THMC_1296	ENOG4105X0D	Fimbrial protein
THMC_1297	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
THMC_1298	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
THMC_1302	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
THMC_1303	ENOG4105C98	muts2 protein
THMC_1306	ENOG4105F8D	glycoside hydrolase family 4
THMC_1307	ENOG41076QQ	Glycosyl transferase, family 2
THMC_1309	ENOG4108X8W	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
THMC_1312	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
THMC_1313	ENOG4105W06	Cupin 2, conserved barrel domain protein
THMC_1314	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMC_1317	ENOG4107QMS	site-determining protein
THMC_1318	ENOG4105D1F	ATP-binding protein
THMC_1319	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
THMC_1321	ENOG4108JMX	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
THMC_1323	ENOG4108FN7	Aldo keto reductase
THMC_1327	ENOG4108IUW	ABC transporter
THMC_1334	ENOG4105BZ1	(ABC) transporter
THMC_1335	ENOG4105ZVY	2-oxoisovalerate dehydrogenase, E1 component beta subunit
THMC_1337	ENOG4106HX1	Uncharacterised protein family (UPF0150)
THMC_1338	ENOG4105PGZ	NB-ARC domain
THMC_1342	ENOG4105BZ1	(ABC) transporter
THMC_1343	ENOG4105BZ1	(ABC) transporter
THMC_1345	ENOG4106HX1	Uncharacterised protein family (UPF0150)
THMC_1369	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
THMC_1370	ENOG4107QUF	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
THMC_1371	ENOG4105C1V	Peptidase, M16
THMC_1372	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMC_1374	ENOG4107Z0G	Domain of unknown function DUF20
THMC_1375	ENOG4105E5G	Alpha beta hydrolase fold
THMC_1376	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
THMC_1379	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
THMC_1384	ENOG4105BZU	Histidine kinase
THMC_1385	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THMC_1386	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
THMC_1387	ENOG4105CZX	twitching motility protein
THMC_1388	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
THMC_1389	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
THMC_1390	ENOG4108ZC9	flagellar basal-body rod protein flgc
THMC_1391	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
THMC_1394	ENOG4105C3K	feS assembly ATPase SufC
THMC_1395	ENOG4105DIW	FeS assembly protein SUFB
THMC_1397	ENOG4105C9B	Cysteine desulfurase
THMC_1398	ENOG4107YH3	SUF system FeS assembly protein, NifU family
THMC_1400	ENOG4105CVJ	phosphoglycerate mutase
THMC_1402	ENOG4107RUE	extracellular solute-binding protein family 1
THMC_1403	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
THMC_1404	ENOG4105F38	ABC transporter, permease
THMC_1405	ENOG4105D38	putrescine abc transporter
THMC_1406	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
THMC_1407	ENOG4108TSD	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
THMC_1410	ENOG4107SJN	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
THMC_1411	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
THMC_1412	ENOG4105C89	phosphohexose isomerase
THMC_1414	ENOG41083IT	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
THMC_1415	ENOG4106H78	methyltransferase
THMC_1416	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
THMC_1420	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
THMC_1422	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
THMC_1423	ENOG4107S82	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
THMC_1425	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
THMC_1426	ENOG4105KNE	Phosphatidate cytidylyltransferase
THMC_1427	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
THMC_1428	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
THMC_1429	ENOG4105C5R	Aminotransferase
THMC_1430	ENOG4108JQ1	Dehydrogenase
THMC_1434	ENOG4105CPK	Glycosyl transferase (Group 1
THMC_1439	ENOG4105GSQ	TM1410 hypothetical-related protein
THMC_1443	ENOG4108HKT	sucrose-6-phosphate hydrolase
THMC_1444	ENOG4105ECY	inositol monophosphatase
THMC_1446	ENOG4105DIW	FeS assembly protein SUFB
THMC_1447	ENOG4105C3K	feS assembly ATPase SufC
THMC_1448	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THMC_1451	ENOG4105Y5S	NADH ubiquinone oxidoreductase, 24 kD
THMC_1454	ENOG4105GKE	subunit e
THMC_1455	ENOG4107QIZ	NADH dehydrogenase
THMC_1456	ENOG4107QHI	-hydrogenase
THMC_1457	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
THMC_1458	ENOG41080BE	Methyl-accepting chemotaxis sensory transducer
THMC_1459	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
THMC_1460	ENOG4108JQ0	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
THMC_1461	ENOG4108ZIA	glycerol-3-phosphate responsive antiterminator
THMC_1462	ENOG4107KMQ	bfd domain protein (2fe-2s)-binding domain protein
THMC_1467	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
THMC_1468	ENOG4107RFW	hydrolase family 57
THMC_1470	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
THMC_1471	ENOG4105C9M	aspartyl-trna synthetase
THMC_1472	ENOG41084GC	stage II sporulation protein
THMC_1473	ENOG4107RB4	Cytidine monophosphate kinase
THMC_1474	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
THMC_1475	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
THMC_1476	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
THMC_1477	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
THMC_1480	ENOG4108JA2	transcriptioN-repair coupling factor
THMC_1481	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
THMC_1482	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
THMC_1483	ENOG4108UJD	30S ribosomal protein S9
THMC_1484	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
THMC_1485	ENOG41081BK	membrane protein-like protein
THMC_1486	ENOG4105K46	50S ribosomal protein l27
THMC_1488	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
THMC_1491	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
THMC_1492	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
THMC_1493	ENOG41084AH	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
THMC_1494	ENOG41085QA	50S ribosomal protein l34
THMC_1495	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
THMC_1496	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
THMC_1497	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
THMC_1498	ENOG4105DHT	Metal Dependent Phosphohydrolase
THMC_1500	ENOG4105EPR	degv family
THMC_1501	ENOG4105DKQ	ROK family
THMC_1502	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
THMC_1503	ENOG4108ZT0	50S ribosomal protein l17
THMC_1504	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
THMC_1505	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
THMC_1506	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
THMC_1507	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THMC_1508	ENOG41086MH	50S ribosomal protein L36
THMC_1509	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
THMC_1511	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
THMC_1512	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
THMC_1513	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
THMC_1514	ENOG4105VPB	50S ribosomal protein L30
THMC_1515	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
THMC_1516	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
THMC_1517	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
THMC_1518	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
THMC_1519	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
THMC_1520	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THMC_1521	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
THMC_1522	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
THMC_1523	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
THMC_1524	ENOG41084ME	50s ribosomal protein l29
THMC_1525	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
THMC_1526	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
THMC_1527	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
THMC_1528	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
THMC_1529	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THMC_1530	ENOG4105KZR	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
THMC_1531	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
THMC_1532	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
THMC_1533	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
THMC_1534	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
THMC_1535	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THMC_1536	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
THMC_1537	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
THMC_1539	ENOG4105C9A	Phoh family
THMC_1540	ENOG4105CTJ	Metal Dependent Phosphohydrolase
THMC_1541	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
THMC_1544	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
THMC_1545	ENOG4105CDE	UPF0348 protein
THMC_1548	ENOG4105CH2	amidohydrolase
THMC_1549	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
THMC_1551	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
THMC_1552	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
THMC_1553	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
THMC_1554	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
THMC_1555	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
THMC_1562	ENOG4105EIS	1,4-dihydroxy-2-naphthoate octaprenyltransferase
THMC_1564	ENOG4105BZJ	Electron transfer flavoprotein
THMC_1565	ENOG4105C10	Electron transfer flavoprotein
THMC_1566	ENOG4105DWH	electron transfer flavoprotein-ubiquinone oxidoreductase
THMC_1567	ENOG41090P5	ferredoxin-like protein
THMC_1571	ENOG4105EPH	radical SAM domain protein
THMC_1573	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
THMC_1574	ENOG4105TZT	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
THMC_1576	ENOG4105CGA	flagellar basal-body rod protein FlgG
THMC_1577	ENOG4105KTQ	flagellar basal-body rod protein
THMC_1581	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
THMC_1582	ENOG4105DCI	Phosphohydrolase
THMC_1584	ENOG4107UKG	Glycosyl transferase, family 4
THMC_1585	ENOG4105CBJ	Metal-dependent enzyme
THMC_1586	ENOG4105NBF	ammecr1 domain protein
THMC_1588	ENOG4105CJ2	(LipO)protein
THMC_1591	ENOG4108Z03	MAF-like protein
THMC_1592	ENOG4105W5Q	DNA repair protein (RadC
THMC_1594	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
THMC_1596	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
THMC_1599	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
THMC_1600	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THMC_1601	ENOG4105K5M	30s ribosomal protein S16
THMC_1602	ENOG41084QK	UPF0109 protein
THMC_1603	ENOG410836E	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
THMC_1604	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
THMC_1605	ENOG4108WTY	tRNA (Guanine-N(1)-)-methyltransferase
THMC_1606	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
THMC_1607	ENOG4105C3F	Signal peptidase i
THMC_1609	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
THMC_1611	ENOG4105DX0	Hemolysin A
THMC_1613	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
THMC_1614	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
THMC_1615	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
THMC_1619	ENOG4105MJ2	Competence protein
THMC_1620	ENOG4105D1Z	hydroxypyruvate reductase
THMC_1623	ENOG4105BZU	Histidine kinase
THMC_1630	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
THMC_1631	ENOG41085B1	50s ribosomal protein L35
THMC_1632	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
THMC_1633	ENOG4105D1F	ATP-binding protein
THMC_1634	ENOG4105BZU	Histidine kinase
THMC_1635	ENOG4105SFS	phosphoesterase RecJ domain protein
THMC_1636	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
THMC_1637	ENOG4106M28	alanine racemase domain protein
THMC_1638	ENOG4105EMN	RNA polymerase sigma factor
THMC_1641	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THMC_1642	ENOG4108Z3G	3H domain protein
THMC_1643	ENOG41079KZ	Major Facilitator Superfamily
THMC_1644	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
THMC_1645	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
THMC_1646	ENOG4105C03	ribonuclease
THMC_1647	ENOG4105MS2	ribosomal subunit Interface protein
THMC_1648	ENOG4105EPR	degv family
THMC_1649	ENOG41082J0	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THMC_1650	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
THMC_1651	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
THMC_1652	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
THMC_1653	ENOG41085KK	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THMC_1654	ENOG41084Y9	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THMC_1655	ENOG410855G	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
THMC_1656	ENOG4107RFS	it plays a direct role in the translocation of protons across the membrane (By similarity)
THMC_1659	ENOG4108W5Z	CheC domain protein
THMC_1660	ENOG4105C2M	dna polymerase I
THMC_1662	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
THMC_1664	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
THMC_1665	ENOG4105CNT	hydrolase family 2
THMC_1667	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
THMC_1668	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
THMC_1669	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
THMC_1670	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
THMC_1673	ENOG4105K8N	protein family UPF0079, ATPase
THMC_1674	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
THMC_1676	ENOG4107RH8	nuclease SbcCD subunit D
THMC_1677	ENOG4107WZZ	SMC domain protein
THMC_1679	ENOG4108IUW	ABC transporter
THMC_1680	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
THMC_1682	ENOG41084X0	Dihydrofolate reductase
THMC_1683	ENOG4105CXT	aspartate transcarbamylase
THMC_1684	ENOG4108Q27	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)
THMC_1685	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
THMC_1686	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
THMC_1689	ENOG4108WF2	Metal Dependent Phosphohydrolase
THMC_1692	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
THMC_1695	ENOG4105BZU	Histidine kinase
THMC_1696	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
THMC_1698	ENOG410857I	Binds directly to 16S ribosomal RNA (By similarity)
THMC_1699	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
THMC_1702	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
THMC_1703	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
THMC_1704	ENOG4108JJB	ABC transporter
THMC_1705	ENOG4107Y49	methyltransferase
THMC_1707	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
THMC_1708	ENOG4105C93	Xylose Isomerase
THMC_1714	ENOG4105D00	flagellar biosynthetic protein flhB
THMC_1720	ENOG4105CPI	Metal Dependent Phosphohydrolase
THMC_1724	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
THMC_1725	ENOG4105VEQ	Cold shock protein
THMC_1726	ENOG41084K4	Binds the 23S rRNA (By similarity)
THMC_1727	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
THMC_1728	ENOG4107Y2H	ErfK ybiS ycfS ynhG family protein
THMC_1729	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
THMC_1730	ENOG41065EC	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
THMC_1731	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
THMC_1736	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
THMC_1740	ENOG4105CHM	Aminotransferase
THMC_1741	ENOG4108ESY	Metal dependent phosphohydrolase
THMC_1743	ENOG4107QJQ	Mate efflux family protein
THMC_1745	ENOG4105E0M	Sulfatase
THMC_1747	ENOG4105CRK	lysyL-tRNA synthetase
THMC_1748	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
THMC_1749	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
THMC_1750	ENOG4105CIE	May be required for sporulation (By similarity)
THMC_1751	ENOG4105CHW	UPF0052 protein
THMC_1755	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
THMC_1757	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
THMC_1759	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
THMC_1760	ENOG4105DJV	ribulose-phosphate 3-epimerase
THMC_1761	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
THMC_1762	ENOG41082BV	acetyltransferase
THMC_1765	ENOG4105CD3	dihydroorotase
THMC_1766	ENOG4105CHR	reductase
THMC_1767	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
THMC_1770	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
THMC_1772	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
THMC_1773	ENOG4105DFA	alanine racemase domain protein
THMC_1775	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
THMC_1776	ENOG4105QGT	Phosphate uptake regulator
THMC_1778	ENOG4105CDU	Replicative dna helicase
THMC_1779	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
THMC_1782	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
THMC_1783	ENOG4105C2N	RNA methyltransferase TrmH family group 3
THMC_1784	ENOG4105D4U	had-superfamily hydrolase, subfamily iia
THMC_1785	ENOG4108FN7	Aldo keto reductase
THMC_1788	ENOG4107QSI	ABC, transporter
THMC_1789	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
THMC_1790	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
THMC_1791	ENOG4105C3U	ABC transporter
THMC_1792	ENOG4108JQ7	(ABC) transporter
THMC_1793	ENOG4108K2F	hydrolase Family 5
THMC_1795	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
THMC_1796	ENOG4105CKM	Branched-chain carboxylic acid kinase
THMC_1797	ENOG4107RE7	phosphate butyryltransferase
THMC_1798	ENOG4105CKM	Branched-chain carboxylic acid kinase
THMC_1805	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
THMC_1807	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
THMC_1809	ENOG4105M7K	Involved in the transcription termination process (By similarity)
THMC_1810	ENOG4105CKU	formyltetrahydrofolate synthetase
THMC_1811	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
THMC_1812	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
THMC_1814	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
THMC_1818	ENOG4105E3H	phosphoglycerate mutase
THMC_1820	ENOG4105I3K	Ferric uptake regulator, Fur family
THMC_1821	ENOG4105CHV	Transcription elongation factor NusA
THMC_1822	ENOG4108396	Required for maturation of 30S ribosomal subunits (By similarity)
THMC_1824	ENOG4105CDH	Citrulline--aspartate ligase
THMC_1825	ENOG4105CH7	arginosuccinase
THMC_1826	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
THMC_1827	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
THMC_1828	ENOG4105CAS	nag kinase
THMC_1829	ENOG4105C8Y	Acetylornithine aminotransferase
THMC_1833	ENOG4105BZU	Histidine kinase
THMC_1842	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
THMC_1843	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
THMC_1849	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
THMC_1853	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
THMC_1855	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
THMC_1857	ENOG410695F	Crispr-associated protein, Csm1 family
THMC_1862	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
THMC_1863	ENOG4105FGV	Chromate
THMC_1865	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
THMC_1866	ENOG4105GRF	N-glycosylase DNA lyase
THMC_1867	ENOG4107QJR	hflk protein
THMC_1868	ENOG4105EPW	hflc protein
THMC_1870	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
THMC_1871	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
THMC_1872	ENOG4108R6K	riboflavin synthase, subunit alpha
THMC_1873	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
THMC_1874	ENOG4105BZU	Histidine kinase
THMC_1877	ENOG4108T5G	Adenylate
THMC_1878	ENOG4107V4V	glycoside hydrolase family 4
THMC_1879	ENOG4108IUK	alpha amylase, catalytic
THMC_1880	ENOG4105EG2	ABC transporter, permease
THMC_1881	ENOG4105D56	permease protein
THMC_1882	ENOG4107FKK	extracellular solute-binding protein family 1
THMC_1883	ENOG4105CG3	alpha amylase, catalytic region
THMC_1888	ENOG4108IUM	Glycogen debranching enzyme
THMC_1890	ENOG4105E2R	ROK family
THMC_1891	ENOG4105C2J	ABC transporter
THMC_1892	ENOG4105CNN	ABC, transporter
THMC_1893	ENOG4105D4B	ABC, transporter
THMC_1896	ENOG4107T3P	ABC, transporter
THMC_1898	ENOG4105E2V	Glycosyltransferase 36
THMC_1903	ENOG4105DRS	transport system, permease
THMC_1904	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
THMC_1906	ENOG4105ETE	Transcriptional regulator (LacI family
THMC_1907	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
THMC_1908	ENOG4108489	Modulates RecA activity (By similarity)
THMC_1909	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
THMC_1910	ENOG41081HM	2'-5' rna ligase
THMC_1911	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
THMC_1912	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
THMC_1915	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
THMC_1917	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
THMC_1918	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
THMC_1919	ENOG4105DAN	ATP-dependent protease
THMC_1920	ENOG4107U53	septum site-determining protein minD
THMC_1922	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
THMC_1924	ENOG4105VEQ	Cold shock protein
THMC_1925	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
THMC_1926	ENOG4108RE9	Phosphodiesterase
THMC_1928	ENOG4105CGH	5'-nucleotidase