locus-tag	class	description
THMC_0002	COG4948	Mandelate Racemase Muconate Lactonizing
THMC_0004	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
THMC_0010	COG0840	transmembrane signaling receptor activity
THMC_0011	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THMC_0012	COG1144	Oxidoreductase
THMC_0013	COG0674	pyruvate-flavodoxin oxidoreductase activity
THMC_0014	COG1013	pyruvate-flavodoxin oxidoreductase activity
THMC_0015	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_0016	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
THMC_0017	COG1993	acr, cog1993
THMC_0018	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
THMC_0019	COG0840	transmembrane signaling receptor activity
THMC_0023	COG4608	Belongs to the ABC transporter superfamily
THMC_0024	COG0444	Belongs to the ABC transporter superfamily
THMC_0026	COG0601	transmembrane transport
THMC_0027	COG4166	transmembrane transport
THMC_0032	COG1618	nucleotide phosphatase activity, acting on free nucleotides
THMC_0033	COG2199	diguanylate cyclase activity
THMC_0033	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_0034	COG0720	synthase
THMC_0035	COG1469	GTP cyclohydrolase I activity
THMC_0036	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
THMC_0037	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
THMC_0037	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
THMC_0038	COG0006	proline dipeptidase activity
THMC_0039	COG1132	(ABC) transporter
THMC_0043	COG0675	Transposase, IS605 OrfB family
THMC_0045	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMC_0047	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
THMC_0047	COG1918	ferrous iron import across plasma membrane
THMC_0051	COG3661	Belongs to the glycosyl hydrolase 67 family
THMC_0052	COG0747	negative chemotaxis
THMC_0053	COG4608	Belongs to the ABC transporter superfamily
THMC_0054	COG0444	Belongs to the ABC transporter superfamily
THMC_0055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_0056	COG0601	transmembrane transport
THMC_0057	COG3693	PFAM glycoside hydrolase, family 10
THMC_0060	COG1904	glucuronate isomerase
THMC_0061	COG1414	Transcriptional regulator
THMC_0062	COG0800	Aldolase
THMC_0064	COG0246	Mannitol dehydrogenase
THMC_0065	COG1312	Catalyzes the dehydration of D-mannonate
THMC_0068	COG0601	transmembrane transport
THMC_0069	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_0070	COG0444	Belongs to the ABC transporter superfamily
THMC_0071	COG4608	Belongs to the ABC transporter superfamily
THMC_0073	COG3458	cephalosporin-C deacetylase activity
THMC_0074	COG1120	ATPase activity
THMC_0075	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
THMC_0076	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
THMC_0077	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
THMC_0078	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMC_0082	COG0728	peptidoglycan biosynthetic process
THMC_0083	COG1355	regulation of microtubule-based process
THMC_0091	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
THMC_0092	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
THMC_0092	COG3116	cell division
THMC_0093	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
THMC_0094	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMC_0096	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
THMC_0104	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
THMC_0106	COG1940	carbohydrate kinase activity
THMC_0108	COG1172	Belongs to the binding-protein-dependent transport system permease family
THMC_0111	COG1129	ABC transporter
THMC_0112	COG1070	Carbohydrate kinase
THMC_0116	COG0778	Nitroreductase
THMC_0117	COG1509	lysine 2,3-aminomutase activity
THMC_0119	COG0803	Belongs to the bacterial solute-binding protein 9 family
THMC_0120	COG1121	(ABC) transporter
THMC_0121	COG1108	ABC-type Mn2 Zn2 transport systems permease components
THMC_0122	COG0745	RESPONSE REGULATOR receiver
THMC_0127	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
THMC_0128	COG1335	isochorismatase
THMC_0129	COG0492	ferredoxin-NADP+ reductase activity
THMC_0131	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THMC_0132	COG0159	tryptophan synthase activity
THMC_0133	COG0133	tryptophan synthase activity
THMC_0134	COG0135	phosphoribosylanthranilate isomerase activity
THMC_0135	COG0134	indole-3-glycerol-phosphate synthase activity
THMC_0136	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
THMC_0136	COG0512	Glutamine amidotransferase of anthranilate synthase
THMC_0137	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
THMC_0138	COG0745	RESPONSE REGULATOR receiver
THMC_0138	COG3706	GGDEF domain
THMC_0141	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
THMC_0142	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
THMC_0143	COG0799	negative regulation of ribosome biogenesis
THMC_0144	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMC_0145	COG0416	fatty acid biosynthetic process
THMC_0146	COG0333	Belongs to the bacterial ribosomal protein bL32 family
THMC_0151	COG1785	Belongs to the alkaline phosphatase family
THMC_0154	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
THMC_0155	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
THMC_0161	COG0632	four-way junction helicase activity
THMC_0162	COG0285	dihydrofolate synthase activity
THMC_0163	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
THMC_0164	COG0495	leucyl-tRNA aminoacylation
THMC_0165	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THMC_0167	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
THMC_0168	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
THMC_0169	COG1110	DNA topoisomerase II activity
THMC_0170	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
THMC_0171	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMC_0173	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
THMC_0174	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
THMC_0183	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_0184	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMC_0184	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMC_0185	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMC_0192	COG4139	cobalamin transport
THMC_0193	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
THMC_0194	COG2359	stage V sporulation protein S
THMC_0199	COG0390	transport system, permease component
THMC_0200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THMC_0204	COG0037	tRNA processing
THMC_0205	COG0542	response to heat
THMC_0206	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
THMC_0207	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
THMC_0212	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
THMC_0214	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THMC_0215	COG0469	pyruvate kinase activity
THMC_0216	COG0205	6-phosphofructokinase activity
THMC_0218	COG0404	The glycine cleavage system catalyzes the degradation of glycine
THMC_0219	COG0509	glycine decarboxylation via glycine cleavage system
THMC_0220	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMC_0221	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
THMC_0223	COG0752	glycyl-tRNA synthetase alpha subunit
THMC_0224	COG0751	glycine-tRNA ligase activity
THMC_0225	COG1157	protein secretion by the type III secretion system
THMC_0227	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMC_0228	COG1766	The M ring may be actively involved in energy transduction
THMC_0229	COG1122	ATPase activity
THMC_0231	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
THMC_0231	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
THMC_0232	COG2515	1-aminocyclopropane-1-carboxylate deaminase
THMC_0238	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
THMC_0239	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
THMC_0240	COG0772	Belongs to the SEDS family
THMC_0241	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
THMC_0242	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMC_0243	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
THMC_0244	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
THMC_0246	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THMC_0247	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
THMC_0250	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMC_0251	COG4656	Part of a membrane complex involved in electron transport
THMC_0252	COG4658	electron transport chain
THMC_0254	COG4660	Part of a membrane complex involved in electron transport
THMC_0256	COG2878	Part of a membrane complex involved in electron transport
THMC_0256	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMC_0257	COG0758	DNA mediated transformation
THMC_0258	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
THMC_0259	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMC_0260	COG0792	nuclease activity
THMC_0261	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
THMC_0262	COG0227	Belongs to the bacterial ribosomal protein bL28 family
THMC_0265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
THMC_0266	COG1181	Belongs to the D-alanine--D-alanine ligase family
THMC_0268	COG0306	phosphate transporter
THMC_0269	COG0592	DNA-directed DNA polymerase activity
THMC_0270	COG0445	tRNA wobble uridine modification
THMC_0271	COG1187	pseudouridine synthase activity
THMC_0272	COG0322	excinuclease ABC activity
THMC_0273	COG0776	regulation of translation
THMC_0274	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
THMC_0275	COG0646	methionine synthase
THMC_0275	COG1410	methionine synthase
THMC_0277	COG0646	methionine synthase
THMC_0277	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
THMC_0279	COG0574	Belongs to the PEP-utilizing enzyme family
THMC_0279	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
THMC_0280	COG0191	fructose-bisphosphate aldolase activity
THMC_0281	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
THMC_0283	COG2160	L-arabinose isomerase activity
THMC_0285	COG1175	transmembrane transport
THMC_0286	COG0395	ABC-type sugar transport system, permease component
THMC_0288	COG3534	alpha-L-arabinofuranosidase
THMC_0290	COG0235	Class ii aldolase
THMC_0292	COG0371	Dehydrogenase
THMC_0294	COG1132	(ABC) transporter
THMC_0295	COG1132	(ABC) transporter
THMC_0296	COG0205	6-phosphofructokinase activity
THMC_0297	COG0372	Belongs to the citrate synthase family
THMC_0298	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THMC_0299	COG0066	3-isopropylmalate dehydratase activity
THMC_0300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
THMC_0301	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
THMC_0302	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
THMC_0303	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THMC_0304	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_0305	COG1063	alcohol dehydrogenase
THMC_0308	COG0601	transmembrane transport
THMC_0309	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_0310	COG4608	Belongs to the ABC transporter superfamily
THMC_0315	COG1501	Belongs to the glycosyl hydrolase 31 family
THMC_0316	COG0747	negative chemotaxis
THMC_0319	COG0673	inositol 2-dehydrogenase activity
THMC_0320	COG0667	Aldo Keto reductase
THMC_0324	COG2217	Heavy metal translocating P-type atpase
THMC_0325	COG2226	methyltransferase
THMC_0329	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
THMC_0331	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
THMC_0332	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_0333	COG1737	Transcriptional regulator
THMC_0334	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THMC_0338	COG1574	metal-dependent hydrolase with the TIM-barrel fold
THMC_0339	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
THMC_0340	COG0284	orotidine-5'-phosphate decarboxylase activity
THMC_0341	COG0167	dihydroorotate dehydrogenase activity
THMC_0342	COG0543	2 iron, 2 sulfur cluster binding
THMC_0343	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMC_0344	COG1073	alpha beta
THMC_0345	COG1032	radical SAM domain protein
THMC_0351	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
THMC_0353	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
THMC_0354	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
THMC_0355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
THMC_0356	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
THMC_0356	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
THMC_0357	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
THMC_0359	COG0577	efflux transmembrane transporter activity
THMC_0359	COG1136	(ABC) transporter
THMC_0360	COG1136	(ABC) transporter
THMC_0361	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
THMC_0364	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
THMC_0366	COG1597	lipid kinase activity
THMC_0368	COG3956	TIGRFAM MazG family protein
THMC_0370	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
THMC_0372	COG0366	Alpha amylase catalytic
THMC_0373	COG1362	aminopeptidase activity
THMC_0374	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
THMC_0378	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
THMC_0379	COG1438	arginine binding
THMC_0381	COG0443	Heat shock 70 kDa protein
THMC_0382	COG0071	Belongs to the small heat shock protein (HSP20) family
THMC_0383	COG4869	propanediol catabolic process
THMC_0384	COG0730	response to heat
THMC_0385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
THMC_0386	COG0446	pyridine nucleotide-disulphide oxidoreductase
THMC_0389	COG1194	a g-specific adenine glycosylase
THMC_0390	COG0778	Nitroreductase
THMC_0393	COG0778	Nitroreductase
THMC_0396	COG1131	(ABC) transporter
THMC_0397	COG0438	transferase activity, transferring glycosyl groups
THMC_0401	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
THMC_0401	COG0493	'glutamate synthase
THMC_0402	COG0069	glutamate synthase activity
THMC_0402	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
THMC_0403	COG0067	glutamate synthase
THMC_0406	COG3850	Histidine kinase
THMC_0406	COG5002	protein histidine kinase activity
THMC_0407	COG1435	thymidine kinase activity
THMC_0408	COG0004	ammonium transporteR
THMC_0409	COG0347	Belongs to the P(II) protein family
THMC_0411	COG1013	pyruvate-flavodoxin oxidoreductase activity
THMC_0414	COG2201	protein-glutamate methylesterase activity
THMC_0415	COG0739	heme binding
THMC_0418	COG1063	alcohol dehydrogenase
THMC_0419	COG1402	creatininase
THMC_0420	COG0673	inositol 2-dehydrogenase activity
THMC_0422	COG1082	Xylose isomerase domain protein TIM barrel
THMC_0423	COG0672	)-iron permease
THMC_0425	COG1175	transmembrane transport
THMC_0426	COG3833	ABC-type maltose transport systems, permease component
THMC_0427	COG3842	ATPase activity
THMC_0429	COG0371	Dehydrogenase
THMC_0434	COG1902	pentaerythritol trinitrate reductase activity
THMC_0435	COG0840	transmembrane signaling receptor activity
THMC_0436	COG0395	ABC-type sugar transport system, permease component
THMC_0437	COG1175	transmembrane transport
THMC_0439	COG3866	Pectate lyase
THMC_0440	COG1486	melibiose metabolic process
THMC_0444	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
THMC_0445	COG1802	Transcriptional regulator
THMC_0447	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_0449	COG1070	Carbohydrate kinase
THMC_0450	COG1027	Aspartate ammonia-lyase
THMC_0452	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
THMC_0453	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
THMC_0454	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
THMC_0455	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
THMC_0460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
THMC_0462	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THMC_0463	COG0250	Participates in transcription elongation, termination and antitermination
THMC_0464	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
THMC_0465	COG0081	regulation of translation
THMC_0466	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
THMC_0467	COG0222	ribosome binding
THMC_0468	COG0085	RNA polymerase activity
THMC_0469	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
THMC_0471	COG0587	DNA-directed DNA polymerase activity
THMC_0472	COG0564	pseudouridine synthase activity
THMC_0473	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
THMC_0475	COG0217	transcriptional regulatory protein
THMC_0477	COG0745	RESPONSE REGULATOR receiver
THMC_0481	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
THMC_0482	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
THMC_0484	COG1335	isochorismatase
THMC_0487	COG1196	nuclear chromosome segregation
THMC_0488	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
THMC_0489	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
THMC_0490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
THMC_0496	COG1116	anion transmembrane transporter activity
THMC_0498	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
THMC_0500	COG2151	metal-sulfur cluster biosynthetic enzyme
THMC_0501	COG2890	protein-(glutamine-N5) methyltransferase activity
THMC_0503	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
THMC_0505	COG0180	Tryptophanyl-tRNA synthetase
THMC_0506	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
THMC_0507	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
THMC_0508	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
THMC_0511	COG0444	Belongs to the ABC transporter superfamily
THMC_0513	COG4608	Belongs to the ABC transporter superfamily
THMC_0514	COG0444	Belongs to the ABC transporter superfamily
THMC_0515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_0516	COG0601	transmembrane transport
THMC_0517	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
THMC_0518	COG0459	protein refolding
THMC_0520	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
THMC_0520	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
THMC_0523	COG1573	uracil-dna glycosylase
THMC_0525	COG0606	chelatase, subunit chli
THMC_0526	COG0442	prolyl-tRNA aminoacylation
THMC_0527	COG1242	4 iron, 4 sulfur cluster binding
THMC_0532	COG0482	sulfurtransferase activity
THMC_0533	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
THMC_0534	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
THMC_0538	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
THMC_0539	COG1923	regulation of RNA biosynthetic process
THMC_0540	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
THMC_0541	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
THMC_0542	COG2608	mercury ion transmembrane transporter activity
THMC_0543	COG4608	Belongs to the ABC transporter superfamily
THMC_0544	COG0747	negative chemotaxis
THMC_0545	COG0601	transmembrane transport
THMC_0546	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_0547	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THMC_0550	COG4717	serine-type aminopeptidase activity
THMC_0552	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
THMC_0554	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
THMC_0554	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
THMC_0557	COG1131	(ABC) transporter
THMC_0558	COG0083	homoserine kinase activity
THMC_0559	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
THMC_0560	COG0527	aspartate kinase activity
THMC_0561	COG0028	Belongs to the TPP enzyme family
THMC_0562	COG0440	acetolactate synthase activity
THMC_0563	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
THMC_0564	COG0129	dihydroxy-acid dehydratase activity
THMC_0565	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMC_0566	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
THMC_0567	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
THMC_0568	COG0066	3-isopropylmalate dehydratase activity
THMC_0569	COG0473	3-isopropylmalate dehydrogenase activity
THMC_0570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
THMC_0571	COG0505	Belongs to the CarA family
THMC_0574	COG0598	Magnesium transport protein CorA
THMC_0579	COG1489	DNA binding
THMC_0581	COG1959	2 iron, 2 sulfur cluster binding
THMC_0584	COG0552	protein localization to endoplasmic reticulum
THMC_0585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
THMC_0586	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
THMC_0587	COG0815	Transfers the fatty acyl group on membrane lipoproteins
THMC_0588	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
THMC_0589	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
THMC_0590	COG2176	DNA-directed DNA polymerase activity
THMC_0591	COG0456	acetyltransferase
THMC_0592	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
THMC_0594	COG0037	tRNA processing
THMC_0595	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
THMC_0600	COG0673	inositol 2-dehydrogenase activity
THMC_0601	COG0697	spore germination
THMC_0602	COG1227	inorganic diphosphatase activity
THMC_0602	COG0517	IMP dehydrogenase activity
THMC_0603	COG1077	Cell shape determining protein MreB Mrl
THMC_0606	COG0768	penicillin binding
THMC_0610	COG2252	PERMEase
THMC_0612	COG1175	transmembrane transport
THMC_0614	COG0395	ABC-type sugar transport system, permease component
THMC_0619	COG0360	Binds together with S18 to 16S ribosomal RNA
THMC_0620	COG0629	single-stranded DNA binding
THMC_0621	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
THMC_0623	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMC_0634	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THMC_0634	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
THMC_0635	COG0438	transferase activity, transferring glycosyl groups
THMC_0635	COG0297	glycogen (starch) synthase activity
THMC_0637	COG1216	Glycosyl transferase, family 2
THMC_0637	COG1442	glycosyl transferase family 8
THMC_0638	COG0438	transferase activity, transferring glycosyl groups
THMC_0640	COG0438	transferase activity, transferring glycosyl groups
THMC_0643	COG0438	transferase activity, transferring glycosyl groups
THMC_0646	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
THMC_0648	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
THMC_0649	COG3951	Flagellar rod assembly protein muramidase FlgJ
THMC_0649	COG1705	Flagellar rod assembly protein muramidase FlgJ
THMC_0654	COG1596	polysaccharide export
THMC_0656	COG1011	Hydrolase
THMC_0660	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMC_0662	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
THMC_0666	COG0561	phosphatase activity
THMC_0668	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_0669	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
THMC_0670	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
THMC_0671	COG1476	TRANSCRIPTIONal
THMC_0672	COG1592	Rubrerythrin
THMC_0673	COG2033	superoxide reductase activity
THMC_0674	COG1773	rubredoxin
THMC_0675	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
THMC_0677	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
THMC_0680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
THMC_0681	COG1045	serine acetyltransferase
THMC_0682	COG0084	hydrolase, TatD family'
THMC_0690	COG1582	Flagellar protein (FlbD)
THMC_0692	COG1360	Flagellar Motor Protein
THMC_0694	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMC_0695	COG1776	CheC inhibitor of MCP methylation
THMC_0695	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
THMC_0701	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
THMC_0702	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
THMC_0703	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
THMC_0704	COG0126	phosphoglycerate kinase activity
THMC_0704	COG0149	triose-phosphate isomerase activity
THMC_0707	COG0736	holo-[acyl-carrier-protein] synthase activity
THMC_0709	COG0544	peptidyl-prolyl cis-trans isomerase activity
THMC_0710	COG0740	serine-type endopeptidase activity
THMC_0713	COG1338	Plays a role in the flagellum-specific transport system
THMC_0715	COG2201	protein-glutamate methylesterase activity
THMC_0716	COG0835	chemotaxis
THMC_0717	COG0643	Histidine kinase
THMC_0717	COG2198	Histidine kinase
THMC_0718	COG1546	Belongs to the CinA family
THMC_0718	COG1058	Belongs to the CinA family
THMC_0719	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMC_0720	COG1136	(ABC) transporter
THMC_0722	COG0357	Ribosomal RNA small subunit methyltransferase G
THMC_0723	COG0095	Lipoate-protein ligase
THMC_0724	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
THMC_0731	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
THMC_0733	COG0511	ligase activity, forming carbon-carbon bonds
THMC_0734	COG0835	chemotaxis
THMC_0735	COG0215	cysteine-tRNA ligase activity
THMC_0736	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
THMC_0737	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
THMC_0738	COG0557	exoribonuclease II activity
THMC_0742	COG0312	modulator of DNA gyrase
THMC_0743	COG0312	modulator of DNA gyrase
THMC_0747	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
THMC_0748	COG1490	D-aminoacyl-tRNA deacylase activity
THMC_0749	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
THMC_0752	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
THMC_0754	COG1482	cell wall glycoprotein biosynthetic process
THMC_0757	COG2199	diguanylate cyclase activity
THMC_0757	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_0758	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THMC_0759	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
THMC_0760	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
THMC_0762	COG0438	transferase activity, transferring glycosyl groups
THMC_0765	COG0793	Belongs to the peptidase S41A family
THMC_0766	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
THMC_0769	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
THMC_0771	COG1486	melibiose metabolic process
THMC_0772	COG2226	methyltransferase
THMC_0773	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
THMC_0774	COG0426	domain, Protein
THMC_0775	COG0463	Glycosyl transferase, family 2
THMC_0775	COG1216	Glycosyl transferase, family 2
THMC_0776	COG0463	Glycosyl transferase, family 2
THMC_0776	COG0457	Tetratricopeptide repeat
THMC_0781	COG0052	Belongs to the universal ribosomal protein uS2 family
THMC_0782	COG0393	Putative heavy-metal-binding
THMC_0784	COG1131	(ABC) transporter
THMC_0786	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
THMC_0787	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THMC_0788	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
THMC_0789	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_0790	COG0470	DNA polymerase III
THMC_0791	COG1774	PSP1 C-terminal conserved region
THMC_0794	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
THMC_0804	COG1659	Linocin_M18 bacteriocin protein
THMC_0806	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
THMC_0807	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
THMC_0809	COG0351	phosphomethylpyrimidine kinase
THMC_0809	COG1992	Thiamine-phosphate synthase
THMC_0810	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
THMC_0811	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
THMC_0812	COG1131	(ABC) transporter
THMC_0816	COG2045	Belongs to the ComB family
THMC_0817	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
THMC_0818	COG1268	BioY protein
THMC_0819	COG2070	2-Nitropropane dioxygenase
THMC_0820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
THMC_0821	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
THMC_0822	COG0504	CTP synthase activity
THMC_0823	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
THMC_0824	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMC_0826	COG0450	alkyl hydroperoxide reductase
THMC_0827	COG1846	Transcriptional regulator
THMC_0827	COG1940	carbohydrate kinase activity
THMC_0831	COG0395	ABC-type sugar transport system, permease component
THMC_0832	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
THMC_0834	COG0534	Mate efflux family protein
THMC_0838	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
THMC_0840	COG1979	alcohol dehydrogenase
THMC_0842	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
THMC_0843	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMC_0843	COG0072	phenylalanine-tRNA ligase activity
THMC_0844	COG1309	transcriptional regulator
THMC_0846	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
THMC_0848	COG3842	ATPase activity
THMC_0851	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_0852	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
THMC_0854	COG0187	DNA topoisomerase II activity
THMC_0856	COG0849	cell division
THMC_0857	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
THMC_0860	COG0772	Belongs to the SEDS family
THMC_0863	COG2201	protein-glutamate methylesterase activity
THMC_0865	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
THMC_0866	COG4535	Mg2 and Co2 transporter CorC
THMC_0867	COG0295	cytidine deaminase activity
THMC_0868	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
THMC_0869	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
THMC_0870	COG0484	heat shock protein binding
THMC_0871	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
THMC_0872	COG1420	regulation of RNA biosynthetic process
THMC_0874	COG0009	L-threonylcarbamoyladenylate synthase
THMC_0875	COG5002	protein histidine kinase activity
THMC_0876	COG1639	'signal transduction protein
THMC_0877	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
THMC_0878	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
THMC_0879	COG0196	riboflavin kinase activity
THMC_0881	COG1862	Preprotein translocase
THMC_0882	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMC_0883	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
THMC_0885	COG0359	binds to the 23S rRNA
THMC_0886	COG1234	tRNA 3'-trailer cleavage
THMC_0892	COG0768	penicillin binding
THMC_0894	COG0275	rRNA processing
THMC_0895	COG0542	response to heat
THMC_0896	COG1214	PFAM Peptidase M22, glycoprotease
THMC_0898	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
THMC_0899	COG0148	phosphopyruvate hydratase activity
THMC_0900	COG0674	pyruvate-flavodoxin oxidoreductase activity
THMC_0900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
THMC_0902	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
THMC_0903	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
THMC_0905	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
THMC_0908	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
THMC_0909	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
THMC_0911	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
THMC_0912	COG0750	zinc metalloprotease
THMC_0913	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
THMC_0914	COG2239	Acts as a magnesium transporter
THMC_0915	COG1968	undecaprenyl-diphosphatase activity
THMC_0917	COG0297	glycogen (starch) synthase activity
THMC_0918	COG1085	galactose-1-phosphate uridylyltransferase
THMC_0919	COG2359	stage V sporulation protein S
THMC_0924	COG1191	sigma factor activity
THMC_0925	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
THMC_0926	COG1776	CheC inhibitor of MCP methylation
THMC_0928	COG0455	bacterial-type flagellum organization
THMC_0929	COG1419	protein localization to endoplasmic reticulum
THMC_0930	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMC_0931	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMC_0932	COG1684	flagellar biosynthetic protein fliR
THMC_0933	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THMC_0935	COG3956	TIGRFAM MazG family protein
THMC_0936	COG1392	Phosphate transport regulator
THMC_0937	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
THMC_0939	COG0306	phosphate transporter
THMC_0940	COG0840	transmembrane signaling receptor activity
THMC_0944	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
THMC_0944	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
THMC_0947	COG0220	tRNA (guanine-N7-)-methyltransferase activity
THMC_0948	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
THMC_0949	COG1141	Ferredoxin
THMC_0951	COG3864	Putative metallopeptidase domain
THMC_0956	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THMC_0957	COG0516	GMP reductase activity
THMC_0957	COG0517	IMP dehydrogenase activity
THMC_0958	COG0402	S-adenosylhomocysteine deaminase activity
THMC_0961	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
THMC_0966	COG0174	glutamine synthetase
THMC_0975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
THMC_0976	COG3958	Transketolase
THMC_0977	COG3959	Transketolase, thiamine diphosphate binding domain
THMC_0978	COG1172	Belongs to the binding-protein-dependent transport system permease family
THMC_0979	COG1129	ABC transporter
THMC_0981	COG1879	ABC-type sugar transport system periplasmic component
THMC_0982	COG1869	D-ribose catabolic process
THMC_0983	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
THMC_0984	COG1704	LemA family
THMC_0987	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
THMC_0988	COG1691	(AIR) carboxylase
THMC_0989	COG1606	tRNA processing
THMC_0990	COG4974	Belongs to the 'phage' integrase family
THMC_0995	COG3706	GGDEF domain
THMC_0996	COG0840	transmembrane signaling receptor activity
THMC_1000	COG0425	Belongs to the sulfur carrier protein TusA family
THMC_1004	COG2391	methyltransferase activity
THMC_1005	COG0425	Belongs to the sulfur carrier protein TusA family
THMC_1006	COG2373	Large extracellular alpha-helical protein
THMC_1008	COG3234	Protein of unknown function (DUF1175)
THMC_1012	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
THMC_1020	COG0640	Transcriptional regulator
THMC_1022	COG1895	HEPN domain
THMC_1028	COG2207	Transcriptional regulator
THMC_1029	COG0667	Aldo Keto reductase
THMC_1031	COG0656	L-ascorbic acid biosynthetic process
THMC_1037	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
THMC_1042	COG2814	Major facilitator Superfamily
THMC_1050	COG1131	(ABC) transporter
THMC_1055	COG0662	Cupin 2, conserved barrel domain protein
THMC_1055	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
THMC_1056	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
THMC_1057	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
THMC_1057	COG0140	phosphoribosyl-ATP diphosphatase activity
THMC_1058	COG0107	imidazoleglycerol-phosphate synthase activity
THMC_1059	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
THMC_1060	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
THMC_1061	COG0131	Imidazoleglycerol-phosphate dehydratase
THMC_1062	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
THMC_1063	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
THMC_1064	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
THMC_1065	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
THMC_1067	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
THMC_1069	COG0850	regulation of cytokinetic process
THMC_1074	COG1596	polysaccharide export
THMC_1074	COG1555	photosystem II stabilization
THMC_1076	COG1137	ATPase activity
THMC_1078	COG1324	tolerance protein
THMC_1079	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
THMC_1081	COG2359	stage V sporulation protein S
THMC_1084	COG3250	beta-galactosidase activity
THMC_1085	COG4608	Belongs to the ABC transporter superfamily
THMC_1086	COG0444	Belongs to the ABC transporter superfamily
THMC_1087	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_1088	COG0601	transmembrane transport
THMC_1089	COG0747	negative chemotaxis
THMC_1090	COG1486	melibiose metabolic process
THMC_1091	COG1349	DNA-binding transcription factor activity
THMC_1093	COG4952	isomerase
THMC_1095	COG1070	Carbohydrate kinase
THMC_1099	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
THMC_1101	COG2264	protein methyltransferase activity
THMC_1102	COG0698	ribose 5-phosphate isomerase
THMC_1103	COG1366	Belongs to the anti-sigma-factor antagonist family
THMC_1104	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
THMC_1105	COG1371	PFAM Archease protein family (DUF101 UPF0211)
THMC_1106	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
THMC_1107	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMC_1107	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
THMC_1110	COG0569	domain protein
THMC_1112	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
THMC_1113	COG0124	histidyl-tRNA synthetase
THMC_1116	COG0018	arginyl-trna synthetase
THMC_1117	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
THMC_1118	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
THMC_1119	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
THMC_1120	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
THMC_1122	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
THMC_1124	COG0622	Phosphoesterase
THMC_1125	COG0571	ribonuclease III activity
THMC_1143	COG1653	transport
THMC_1144	COG1175	transmembrane transport
THMC_1146	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
THMC_1152	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
THMC_1153	COG0280	phosphate acetyltransferase
THMC_1154	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
THMC_1155	COG0714	Associated with various cellular activities
THMC_1159	COG0559	Belongs to the binding-protein-dependent transport system permease family
THMC_1161	COG0411	ABC transporter
THMC_1162	COG0410	ABC transporter
THMC_1164	COG0785	Cytochrome C biogenesis protein
THMC_1166	COG0840	transmembrane signaling receptor activity
THMC_1168	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_1168	COG2199	diguanylate cyclase activity
THMC_1170	COG0840	transmembrane signaling receptor activity
THMC_1174	COG0747	negative chemotaxis
THMC_1175	COG4608	Belongs to the ABC transporter superfamily
THMC_1176	COG0444	Belongs to the ABC transporter superfamily
THMC_1177	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_1178	COG0363	glucosamine-6-phosphate deaminase activity
THMC_1179	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
THMC_1180	COG1983	PspC domain protein
THMC_1183	COG0010	Belongs to the arginase family
THMC_1186	COG2239	Acts as a magnesium transporter
THMC_1187	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
THMC_1188	COG2199	diguanylate cyclase activity
THMC_1190	COG1013	pyruvate-flavodoxin oxidoreductase activity
THMC_1191	COG0635	Involved in the biosynthesis of porphyrin-containing compound
THMC_1193	COG0058	SHG alpha-glucan phosphorylase activity
THMC_1194	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_1197	COG1151	hydroxylamine reductase activity
THMC_1202	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THMC_1203	COG0456	acetyltransferase
THMC_1204	COG1516	flagellar protein fliS
THMC_1206	COG0494	nUDIX hydrolase
THMC_1207	COG1196	nuclear chromosome segregation
THMC_1208	COG0667	Aldo Keto reductase
THMC_1210	COG1803	Methylglyoxal synthase
THMC_1212	COG0628	permease
THMC_1216	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
THMC_1217	COG1085	galactose-1-phosphate uridylyltransferase
THMC_1218	COG3345	alpha-galactosidase
THMC_1219	COG3250	beta-galactosidase activity
THMC_1220	COG0444	Belongs to the ABC transporter superfamily
THMC_1222	COG4608	Belongs to the ABC transporter superfamily
THMC_1223	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_1228	COG3833	ABC-type maltose transport systems, permease component
THMC_1229	COG1175	transmembrane transport
THMC_1230	COG2182	Extracellular solute-binding protein
THMC_1231	COG1863	multisubunit Na H antiporter MnhE subunit
THMC_1232	COG2212	antiporter activity
THMC_1235	COG2111	Na H antiporter
THMC_1235	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
THMC_1237	COG0651	ATP synthesis coupled electron transport
THMC_1238	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMC_1240	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMC_1241	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
THMC_1241	COG0649	NAD binding
THMC_1242	COG0649	NAD binding
THMC_1245	COG4608	Belongs to the ABC transporter superfamily
THMC_1246	COG0444	Belongs to the ABC transporter superfamily
THMC_1247	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_1248	COG0601	transmembrane transport
THMC_1249	COG4166	transmembrane transport
THMC_1250	COG1940	carbohydrate kinase activity
THMC_1251	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
THMC_1252	COG0747	negative chemotaxis
THMC_1255	COG0463	Glycosyl transferase, family 2
THMC_1256	COG0438	transferase activity, transferring glycosyl groups
THMC_1257	COG0383	alpha-mannosidase activity
THMC_1258	COG3842	ATPase activity
THMC_1263	COG0210	DNA helicase
THMC_1265	COG0012	GTP binding
THMC_1268	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
THMC_1269	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THMC_1270	COG0047	phosphoribosylformylglycinamidine synthase activity
THMC_1271	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
THMC_1272	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
THMC_1273	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
THMC_1274	COG0138	bifunctional purine biosynthesis protein purh
THMC_1275	COG0151	Belongs to the GarS family
THMC_1278	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
THMC_1278	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
THMC_1279	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
THMC_1280	COG0436	Aminotransferase
THMC_1281	COG1132	(ABC) transporter
THMC_1284	COG0745	RESPONSE REGULATOR receiver
THMC_1285	COG0704	Plays a role in the regulation of phosphate uptake
THMC_1286	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
THMC_1289	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
THMC_1294	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
THMC_1295	COG0626	cystathionine gamma-synthase activity
THMC_1297	COG0154	amidase activity
THMC_1298	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
THMC_1301	COG3842	ATPase activity
THMC_1303	COG1193	negative regulation of DNA recombination
THMC_1306	COG1486	melibiose metabolic process
THMC_1307	COG0463	Glycosyl transferase, family 2
THMC_1309	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THMC_1312	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
THMC_1313	COG0662	Cupin 2, conserved barrel domain protein
THMC_1314	COG0731	radical SAM domain protein
THMC_1314	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
THMC_1317	COG2894	cell division
THMC_1318	COG0489	protein tyrosine kinase activity
THMC_1319	COG2226	methyltransferase
THMC_1321	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
THMC_1323	COG0667	Aldo Keto reductase
THMC_1327	COG4555	ABC transporter
THMC_1334	COG1132	(ABC) transporter
THMC_1335	COG1598	PFAM Uncharacterised protein family UPF0150
THMC_1337	COG1598	PFAM Uncharacterised protein family UPF0150
THMC_1338	COG0457	Tetratricopeptide repeat
THMC_1342	COG1132	(ABC) transporter
THMC_1343	COG1132	(ABC) transporter
THMC_1345	COG1598	PFAM Uncharacterised protein family UPF0150
THMC_1369	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
THMC_1370	COG1185	polyribonucleotide nucleotidyltransferase activity
THMC_1371	COG0612	Peptidase, M16
THMC_1372	COG0517	IMP dehydrogenase activity
THMC_1372	COG0516	GMP reductase activity
THMC_1374	COG0628	permease
THMC_1375	COG2267	carboxylic ester hydrolase activity
THMC_1376	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMC_1379	COG0516	GMP reductase activity
THMC_1379	COG0517	IMP dehydrogenase activity
THMC_1384	COG3852	Histidine kinase
THMC_1385	COG0745	RESPONSE REGULATOR receiver
THMC_1386	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
THMC_1388	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
THMC_1389	COG1815	bacterial-type flagellum-dependent cell motility
THMC_1391	COG1677	Flagellar hook-basal body complex protein FliE
THMC_1394	COG0396	ATPase activity
THMC_1395	COG0719	Fe-S assembly protein
THMC_1397	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
THMC_1398	COG0822	iron-sulfur transferase activity
THMC_1400	COG0406	alpha-ribazole phosphatase activity
THMC_1402	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
THMC_1403	COG3842	ATPase activity
THMC_1404	COG1176	ABC-type spermidine putrescine transport system, permease component I
THMC_1405	COG1177	transmembrane transport
THMC_1406	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
THMC_1410	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
THMC_1411	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
THMC_1412	COG0166	Belongs to the GPI family
THMC_1414	COG0237	dephospho-CoA kinase activity
THMC_1415	COG0742	ribosomal rna small subunit methyltransferase
THMC_1420	COG0542	response to heat
THMC_1422	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
THMC_1423	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
THMC_1425	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
THMC_1426	COG0575	Belongs to the CDS family
THMC_1427	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
THMC_1428	COG0233	cytoplasmic translational termination
THMC_1429	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
THMC_1430	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
THMC_1434	COG0438	transferase activity, transferring glycosyl groups
THMC_1439	COG2342	PFAM TM1410 hypothetical-related protein
THMC_1443	COG1621	beta-fructofuranosidase activity
THMC_1444	COG0483	inositol monophosphate 1-phosphatase activity
THMC_1446	COG0719	Fe-S assembly protein
THMC_1447	COG0396	ATPase activity
THMC_1448	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THMC_1448	COG1213	nucleotidyl transferase
THMC_1451	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THMC_1454	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
THMC_1457	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
THMC_1458	COG0840	transmembrane signaling receptor activity
THMC_1459	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
THMC_1461	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
THMC_1467	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
THMC_1468	COG1543	Belongs to the glycosyl hydrolase 57 family
THMC_1470	COG2050	protein possibly involved in aromatic compounds catabolism
THMC_1470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
THMC_1471	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
THMC_1472	COG1366	Belongs to the anti-sigma-factor antagonist family
THMC_1473	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
THMC_1474	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
THMC_1475	COG0539	negative regulation of cytoplasmic translation
THMC_1476	COG1160	GTP binding
THMC_1477	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
THMC_1480	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
THMC_1481	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
THMC_1482	COG0358	DNA primase activity
THMC_1483	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
THMC_1484	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
THMC_1485	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
THMC_1486	COG0211	Belongs to the bacterial ribosomal protein bL27 family
THMC_1488	COG0261	This protein binds to 23S rRNA in the presence of protein L20
THMC_1491	COG0706	membrane insertase activity
THMC_1492	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
THMC_1493	COG0594	ribonuclease P activity
THMC_1494	COG0230	Belongs to the bacterial ribosomal protein bL34 family
THMC_1495	COG2313	pseudouridylate synthase activity
THMC_1496	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
THMC_1497	COG0218	Necessary for normal cell division and for the maintenance of normal septation
THMC_1498	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_1500	COG1307	EDD domain protein, DegV family
THMC_1501	COG1940	carbohydrate kinase activity
THMC_1502	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
THMC_1503	COG0203	ribosomal protein L17
THMC_1504	COG0202	RNA polymerase activity
THMC_1505	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
THMC_1506	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
THMC_1507	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
THMC_1508	COG0257	Belongs to the bacterial ribosomal protein bL36 family
THMC_1509	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
THMC_1511	COG0563	adenylate kinase activity
THMC_1512	COG0201	protein transport
THMC_1513	COG0200	Binds to the 23S rRNA
THMC_1514	COG1841	ribosomal large subunit assembly
THMC_1515	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
THMC_1516	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
THMC_1517	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
THMC_1518	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
THMC_1519	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
THMC_1520	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
THMC_1521	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
THMC_1522	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
THMC_1523	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
THMC_1524	COG0255	Belongs to the universal ribosomal protein uL29 family
THMC_1525	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
THMC_1526	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
THMC_1527	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
THMC_1528	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
THMC_1529	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
THMC_1530	COG0089	rRNA binding
THMC_1531	COG0088	Forms part of the polypeptide exit tunnel
THMC_1532	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
THMC_1533	COG0051	transcription antitermination factor activity, RNA binding
THMC_1534	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
THMC_1535	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THMC_1536	COG0049	tRNA binding
THMC_1537	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
THMC_1539	COG1702	phosphate starvation-inducible protein PhoH
THMC_1540	COG1480	7TM receptor with intracellular HD hydrolase
THMC_1541	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
THMC_1543	COG2738	Putative neutral zinc metallopeptidase
THMC_1544	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMC_1544	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
THMC_1545	COG1323	Belongs to the UPF0348 family
THMC_1548	COG1473	amidohydrolase
THMC_1549	COG0019	diaminopimelate decarboxylase activity
THMC_1551	COG2171	N-acyltransferase activity
THMC_1552	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
THMC_1553	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
THMC_1554	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
THMC_1555	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
THMC_1561	COG1959	2 iron, 2 sulfur cluster binding
THMC_1562	COG1575	Belongs to the MenA family. Type 1 subfamily
THMC_1564	COG2086	electron transfer activity
THMC_1565	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
THMC_1566	COG0644	oxidoreductase
THMC_1571	COG1032	radical SAM domain protein
THMC_1573	COG1706	bacterial-type flagellum-dependent cell motility
THMC_1574	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
THMC_1577	COG4786	Flagellar basal body rod
THMC_1581	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
THMC_1581	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
THMC_1582	COG1078	dGTPase activity
THMC_1583	COG1086	Polysaccharide biosynthesis protein
THMC_1584	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
THMC_1585	COG3872	metal-dependent enzyme
THMC_1586	COG2078	PFAM AMMECR1 domain protein
THMC_1588	COG1477	protein flavinylation
THMC_1591	COG0424	maF-like protein
THMC_1592	COG2003	Belongs to the UPF0758 family
THMC_1594	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
THMC_1596	COG0343	queuine tRNA-ribosyltransferase activity
THMC_1599	COG1254	Belongs to the acylphosphatase family
THMC_1600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
THMC_1601	COG0228	four-way junction DNA binding
THMC_1602	COG1837	Belongs to the UPF0109 family
THMC_1603	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
THMC_1604	COG0336	Belongs to the RNA methyltransferase TrmD family
THMC_1605	COG4752	Belongs to the RNA methyltransferase TrmD family
THMC_1606	COG0335	large ribosomal subunit rRNA binding
THMC_1607	COG0681	Belongs to the peptidase S26 family
THMC_1609	COG0101	tRNA pseudouridine synthase activity
THMC_1611	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
THMC_1613	COG0653	protein targeting
THMC_1614	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
THMC_1619	COG1040	competence protein
THMC_1620	COG2379	hydroxypyruvate reductase
THMC_1623	COG2203	Gaf domain
THMC_1623	COG2199	diguanylate cyclase activity
THMC_1630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
THMC_1631	COG0291	Belongs to the bacterial ribosomal protein bL35 family
THMC_1632	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
THMC_1633	COG0489	protein tyrosine kinase activity
THMC_1634	COG3706	GGDEF domain
THMC_1635	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
THMC_1636	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THMC_1637	COG3457	Alanine racemase
THMC_1638	COG1595	DNA-templated transcription, initiation
THMC_1641	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_1642	COG1827	regulation of RNA biosynthetic process
THMC_1643	COG0477	Major facilitator Superfamily
THMC_1644	COG0528	UMP kinase activity
THMC_1645	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
THMC_1646	COG1530	ribonuclease E activity
THMC_1647	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
THMC_1648	COG1307	EDD domain protein, DegV family
THMC_1649	COG0355	proton-transporting ATP synthase activity, rotational mechanism
THMC_1650	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
THMC_1651	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
THMC_1652	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
THMC_1653	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMC_1654	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
THMC_1655	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
THMC_1656	COG0356	it plays a direct role in the translocation of protons across the membrane
THMC_1659	COG1406	Chemotaxis phosphatase CheX
THMC_1660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMC_1660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
THMC_1662	COG0584	glycerophosphoryl diester phosphodiesterase
THMC_1664	COG0481	GTPase activity
THMC_1665	COG3250	beta-galactosidase activity
THMC_1667	COG0193	aminoacyl-tRNA hydrolase activity
THMC_1668	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
THMC_1669	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
THMC_1670	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
THMC_1673	COG0802	atpase or kinase
THMC_1674	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
THMC_1676	COG0420	3'-5' exonuclease activity
THMC_1677	COG0419	ATPase involved in DNA repair
THMC_1679	COG4555	ABC transporter
THMC_1680	COG0543	2 iron, 2 sulfur cluster binding
THMC_1682	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
THMC_1683	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
THMC_1683	COG0540	Belongs to the ATCase OTCase family
THMC_1684	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
THMC_1685	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
THMC_1686	COG0157	Belongs to the NadC ModD family
THMC_1689	COG1713	HD superfamily hydrolase involved in NAD metabolism
THMC_1692	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
THMC_1695	COG5002	protein histidine kinase activity
THMC_1696	COG0745	RESPONSE REGULATOR receiver
THMC_1698	COG0268	Binds directly to 16S ribosomal RNA
THMC_1699	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
THMC_1702	COG0242	peptide deformylase activity
THMC_1703	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
THMC_1704	COG1122	ATPase activity
THMC_1705	COG2813	Specifically methylates the guanine in position
THMC_1707	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
THMC_1708	COG2115	Belongs to the xylose isomerase family
THMC_1714	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
THMC_1724	COG3437	response regulator, receiver
THMC_1725	COG1278	Cold shock
THMC_1726	COG0254	rRNA binding
THMC_1727	COG1185	polyribonucleotide nucleotidyltransferase activity
THMC_1728	COG1376	ErfK ybiS ycfS ynhG family protein
THMC_1729	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
THMC_1730	COG1758	RNA polymerase activity
THMC_1731	COG0194	GDP metabolic process
THMC_1736	COG0301	tRNA thio-modification
THMC_1741	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
THMC_1743	COG0534	Mate efflux family protein
THMC_1745	COG1368	sulfuric ester hydrolase activity
THMC_1747	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
THMC_1748	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
THMC_1749	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
THMC_1751	COG0391	Required for morphogenesis under gluconeogenic growth conditions
THMC_1755	COG1739	Uncharacterized protein family UPF0029
THMC_1757	COG0820	rRNA (adenine-C2-)-methyltransferase activity
THMC_1759	COG1162	GTPase activity
THMC_1760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
THMC_1761	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
THMC_1762	COG2153	protein acetylation
THMC_1765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
THMC_1766	COG1028	Short-chain dehydrogenase reductase Sdr
THMC_1767	COG1394	ATPase activity, coupled to movement of substances
THMC_1770	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
THMC_1772	COG2255	four-way junction helicase activity
THMC_1773	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
THMC_1775	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
THMC_1776	COG0704	Plays a role in the regulation of phosphate uptake
THMC_1778	COG0305	Participates in initiation and elongation during chromosome replication
THMC_1779	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
THMC_1782	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
THMC_1783	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
THMC_1784	COG0647	UMP catabolic process
THMC_1785	COG0667	Aldo Keto reductase
THMC_1789	COG0601	transmembrane transport
THMC_1790	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
THMC_1792	COG4608	Belongs to the ABC transporter superfamily
THMC_1795	COG0556	nucleotide-excision repair
THMC_1796	COG3426	butyrate kinase activity
THMC_1797	COG0280	phosphate acetyltransferase
THMC_1798	COG3426	butyrate kinase activity
THMC_1805	COG0556	nucleotide-excision repair
THMC_1807	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
THMC_1809	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
THMC_1810	COG2759	Belongs to the formate--tetrahydrofolate ligase family
THMC_1811	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
THMC_1812	COG1570	exodeoxyribonuclease VII activity
THMC_1813	COG1722	exodeoxyribonuclease VII activity
THMC_1814	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
THMC_1818	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
THMC_1820	COG0735	belongs to the Fur family
THMC_1821	COG0195	Participates in both transcription termination and antitermination
THMC_1822	COG0779	Required for maturation of 30S ribosomal subunits
THMC_1824	COG0137	argininosuccinate synthase activity
THMC_1825	COG0165	Argininosuccinate lyase
THMC_1826	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
THMC_1827	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
THMC_1828	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
THMC_1829	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
THMC_1837	COG3337	CRISPR-associated protein (Cas_Cmr5)
THMC_1842	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
THMC_1843	COG1518	maintenance of DNA repeat elements
THMC_1849	COG0484	heat shock protein binding
THMC_1855	COG1337	RAMP superfamily
THMC_1857	COG1353	crispr-associated protein
THMC_1862	COG0525	valine-tRNA ligase activity
THMC_1863	COG2059	Chromate
THMC_1865	COG0518	GMP synthase (glutamine-hydrolyzing) activity
THMC_1865	COG0519	Catalyzes the synthesis of GMP from XMP
THMC_1866	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
THMC_1867	COG0330	HflC and HflK could
THMC_1868	COG0330	HflC and HflK could
THMC_1870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
THMC_1871	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THMC_1871	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
THMC_1873	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMC_1873	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
THMC_1874	COG3706	GGDEF domain
THMC_1877	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
THMC_1878	COG1486	melibiose metabolic process
THMC_1879	COG0366	Alpha amylase catalytic
THMC_1881	COG1175	transmembrane transport
THMC_1882	COG2182	Extracellular solute-binding protein
THMC_1883	COG0366	Alpha amylase catalytic
THMC_1888	COG1523	belongs to the glycosyl hydrolase 13 family
THMC_1890	COG1940	carbohydrate kinase activity
THMC_1892	COG1172	Belongs to the binding-protein-dependent transport system permease family
THMC_1896	COG1653	transport
THMC_1897	COG2723	6-phospho-beta-galactosidase activity
THMC_1898	COG3459	Glycosyltransferase 36 associated
THMC_1903	COG0395	ABC-type sugar transport system, permease component
THMC_1906	COG1609	Transcriptional regulator
THMC_1907	COG1418	mRNA catabolic process
THMC_1908	COG2137	regulation of response to DNA damage stimulus
THMC_1909	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
THMC_1910	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
THMC_1911	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
THMC_1912	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
THMC_1915	COG1515	deoxyribonuclease V activity
THMC_1917	COG0039	L-malate dehydrogenase activity
THMC_1918	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
THMC_1919	COG1067	ATP-dependent peptidase activity
THMC_1920	COG2894	cell division
THMC_1922	COG0432	Pfam Uncharacterised protein family UPF0047
THMC_1924	COG1278	Cold shock
THMC_1925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
THMC_1926	COG0622	Phosphoesterase
THMC_1928	COG0737	Belongs to the 5'-nucleotidase family