locus-tag	class	description
CTN_0001	COG1476	TRANSCRIPTIONal
CTN_0002	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
CTN_0003	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CTN_0004	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_0006	COG0561	phosphatase activity
CTN_0010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CTN_0012	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTN_0016	COG1011	Hydrolase
CTN_0024	COG1705	Flagellar rod assembly protein muramidase FlgJ
CTN_0024	COG3951	Flagellar rod assembly protein muramidase FlgJ
CTN_0025	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CTN_0026	COG0463	Glycosyl transferase, family 2
CTN_0035	COG1091	dTDP-4-dehydrorhamnose reductase activity
CTN_0038	COG0297	glycogen (starch) synthase activity
CTN_0038	COG0438	transferase activity, transferring glycosyl groups
CTN_0047	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTN_0050	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_0053	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTN_0058	COG0629	single-stranded DNA binding
CTN_0059	COG0360	Binds together with S18 to 16S ribosomal RNA
CTN_0065	COG0395	ABC-type sugar transport system, permease component
CTN_0066	COG1175	transmembrane transport
CTN_0068	COG2252	PERMEase
CTN_0071	COG1126	abc transporter atp-binding protein
CTN_0075	COG1077	Cell shape determining protein MreB Mrl
CTN_0076	COG1227	inorganic diphosphatase activity
CTN_0076	COG0517	IMP dehydrogenase activity
CTN_0077	COG0697	spore germination
CTN_0084	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CTN_0085	COG0037	tRNA processing
CTN_0087	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CTN_0088	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CTN_0089	COG2176	DNA-directed DNA polymerase activity
CTN_0090	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CTN_0091	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CTN_0092	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CTN_0093	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CTN_0094	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CTN_0095	COG0552	protein localization to endoplasmic reticulum
CTN_0097	COG3584	3D domain protein
CTN_0098	COG1959	2 iron, 2 sulfur cluster binding
CTN_0100	COG1489	DNA binding
CTN_0105	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTN_0106	COG0598	Magnesium transport protein CorA
CTN_0110	COG0505	Belongs to the CarA family
CTN_0111	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CTN_0112	COG0473	3-isopropylmalate dehydrogenase activity
CTN_0113	COG0066	3-isopropylmalate dehydratase activity
CTN_0114	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTN_0115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTN_0116	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CTN_0117	COG0129	dihydroxy-acid dehydratase activity
CTN_0118	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CTN_0119	COG0440	acetolactate synthase activity
CTN_0120	COG0028	Belongs to the TPP enzyme family
CTN_0121	COG0527	aspartate kinase activity
CTN_0122	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CTN_0123	COG0083	homoserine kinase activity
CTN_0124	COG1131	(ABC) transporter
CTN_0127	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
CTN_0127	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CTN_0129	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CTN_0131	COG1350	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine
CTN_0132	COG1230	cation diffusion facilitator family transporter
CTN_0133	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CTN_0136	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTN_0137	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_0138	COG0601	transmembrane transport
CTN_0139	COG0747	negative chemotaxis
CTN_0140	COG4608	Belongs to the ABC transporter superfamily
CTN_0142	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CTN_0143	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CTN_0145	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CTN_0149	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CTN_0150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CTN_0151	COG0482	sulfurtransferase activity
CTN_0156	COG1242	4 iron, 4 sulfur cluster binding
CTN_0157	COG0442	prolyl-tRNA aminoacylation
CTN_0158	COG0606	chelatase, subunit chli
CTN_0160	COG1573	uracil-dna glycosylase
CTN_0163	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CTN_0163	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CTN_0166	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CTN_0167	COG0601	transmembrane transport
CTN_0168	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_0169	COG0444	Belongs to the ABC transporter superfamily
CTN_0171	COG4608	Belongs to the ABC transporter superfamily
CTN_0173	COG0444	Belongs to the ABC transporter superfamily
CTN_0175	COG2176	DNA-directed DNA polymerase activity
CTN_0176	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
CTN_0177	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CTN_0178	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
CTN_0179	COG0180	Tryptophanyl-tRNA synthetase
CTN_0181	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
CTN_0182	COG1595	DNA-templated transcription, initiation
CTN_0183	COG2890	protein-(glutamine-N5) methyltransferase activity
CTN_0184	COG2151	metal-sulfur cluster biosynthetic enzyme
CTN_0186	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTN_0187	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CTN_0191	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CTN_0192	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CTN_0193	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CTN_0195	COG1196	nuclear chromosome segregation
CTN_0198	COG3433	isochorismatase activity
CTN_0198	COG1535	isochorismatase
CTN_0200	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CTN_0201	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CTN_0205	COG0745	RESPONSE REGULATOR receiver
CTN_0209	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CTN_0210	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CTN_0211	COG0564	pseudouridine synthase activity
CTN_0212	COG0587	DNA-directed DNA polymerase activity
CTN_0214	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CTN_0216	COG0222	ribosome binding
CTN_0217	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CTN_0218	COG0081	regulation of translation
CTN_0219	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CTN_0220	COG0250	Participates in transcription elongation, termination and antitermination
CTN_0221	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CTN_0223	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
CTN_0224	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CTN_0225	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
CTN_0226	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CTN_0228	COG1027	Aspartate ammonia-lyase
CTN_0229	COG1070	Carbohydrate kinase
CTN_0231	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_0233	COG1802	Transcriptional regulator
CTN_0234	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CTN_0237	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTN_0239	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_0241	COG1234	tRNA 3'-trailer cleavage
CTN_0242	COG3842	ATPase activity
CTN_0243	COG4149	molybdate abc transporter
CTN_0244	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTN_0247	COG0371	Dehydrogenase
CTN_0249	COG3842	ATPase activity
CTN_0250	COG3833	ABC-type maltose transport systems, permease component
CTN_0251	COG1175	transmembrane transport
CTN_0253	COG1082	Xylose isomerase domain protein TIM barrel
CTN_0255	COG0673	inositol 2-dehydrogenase activity
CTN_0256	COG1402	creatininase
CTN_0257	COG1063	alcohol dehydrogenase
CTN_0260	COG0739	heme binding
CTN_0261	COG2201	protein-glutamate methylesterase activity
CTN_0264	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTN_0266	COG0347	Belongs to the P(II) protein family
CTN_0267	COG0004	ammonium transporteR
CTN_0269	COG3850	Histidine kinase
CTN_0269	COG5002	protein histidine kinase activity
CTN_0271	COG0067	glutamate synthase
CTN_0272	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
CTN_0272	COG0069	glutamate synthase activity
CTN_0273	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTN_0273	COG0493	'glutamate synthase
CTN_0274	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTN_0277	COG0438	transferase activity, transferring glycosyl groups
CTN_0279	COG0577	efflux transmembrane transporter activity
CTN_0279	COG1136	(ABC) transporter
CTN_0280	COG1136	(ABC) transporter
CTN_0281	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CTN_0285	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CTN_0287	COG1597	lipid kinase activity
CTN_0289	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTN_0290	COG3956	TIGRFAM MazG family protein
CTN_0292	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CTN_0296	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CTN_0301	COG0467	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction
CTN_0302	COG1438	arginine binding
CTN_0304	COG0443	Heat shock 70 kDa protein
CTN_0305	COG0071	Belongs to the small heat shock protein (HSP20) family
CTN_0306	COG4869	propanediol catabolic process
CTN_0307	COG0730	response to heat
CTN_0311	COG0778	Nitroreductase
CTN_0312	COG1328	CTP reductase activity
CTN_0314	COG1194	a g-specific adenine glycosylase
CTN_0317	COG0446	pyridine nucleotide-disulphide oxidoreductase
CTN_0318	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CTN_0321	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CTN_0322	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CTN_0322	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CTN_0325	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CTN_0326	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CTN_0328	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CTN_0332	COG1032	radical SAM domain protein
CTN_0333	COG1073	alpha beta
CTN_0334	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CTN_0335	COG0167	dihydroorotate dehydrogenase activity
CTN_0336	COG0284	orotidine-5'-phosphate decarboxylase activity
CTN_0337	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CTN_0338	COG1574	metal-dependent hydrolase with the TIM-barrel fold
CTN_0341	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTN_0342	COG1737	Transcriptional regulator
CTN_0343	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_0344	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
CTN_0346	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
CTN_0350	COG2226	methyltransferase
CTN_0351	COG2217	Heavy metal translocating P-type atpase
CTN_0362	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_0363	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_0364	COG1879	ABC-type sugar transport system periplasmic component
CTN_0365	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_0366	COG1129	ABC transporter
CTN_0367	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_0368	COG0673	inositol 2-dehydrogenase activity
CTN_0370	COG1070	Carbohydrate kinase
CTN_0374	COG0667	Aldo Keto reductase
CTN_0378	COG0747	negative chemotaxis
CTN_0379	COG0747	negative chemotaxis
CTN_0380	COG1501	Belongs to the glycosyl hydrolase 31 family
CTN_0384	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTN_0385	COG1063	alcohol dehydrogenase
CTN_0386	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_0387	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTN_0388	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CTN_0389	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
CTN_0391	COG0066	3-isopropylmalate dehydratase activity
CTN_0393	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CTN_0394	COG0372	Belongs to the citrate synthase family
CTN_0395	COG0205	6-phosphofructokinase activity
CTN_0396	COG1132	(ABC) transporter
CTN_0397	COG1132	(ABC) transporter
CTN_0399	COG0371	Dehydrogenase
CTN_0400	COG1070	Carbohydrate kinase
CTN_0406	COG1175	transmembrane transport
CTN_0409	COG2160	L-arabinose isomerase activity
CTN_0411	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CTN_0412	COG0191	fructose-bisphosphate aldolase activity
CTN_0413	COG0574	Belongs to the PEP-utilizing enzyme family
CTN_0413	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CTN_0415	COG0646	methionine synthase
CTN_0415	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CTN_0418	COG1410	methionine synthase
CTN_0418	COG0646	methionine synthase
CTN_0419	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CTN_0420	COG0776	regulation of translation
CTN_0422	COG1187	pseudouridine synthase activity
CTN_0424	COG0592	DNA-directed DNA polymerase activity
CTN_0425	COG0306	phosphate transporter
CTN_0427	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTN_0428	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CTN_0431	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CTN_0432	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CTN_0433	COG0792	nuclease activity
CTN_0434	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTN_0435	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CTN_0436	COG0758	DNA mediated transformation
CTN_0436	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTN_0438	COG4657	Part of a membrane complex involved in electron transport
CTN_0439	COG4660	Part of a membrane complex involved in electron transport
CTN_0440	COG4659	FMN binding
CTN_0441	COG4658	electron transport chain
CTN_0442	COG4656	Part of a membrane complex involved in electron transport
CTN_0443	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTN_0446	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTN_0447	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CTN_0449	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CTN_0450	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CTN_0451	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTN_0452	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CTN_0453	COG0772	Belongs to the SEDS family
CTN_0454	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CTN_0455	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CTN_0461	COG2515	1-aminocyclopropane-1-carboxylate deaminase
CTN_0462	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CTN_0462	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CTN_0463	COG1122	ATPase activity
CTN_0464	COG1766	The M ring may be actively involved in energy transduction
CTN_0465	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTN_0467	COG1157	protein secretion by the type III secretion system
CTN_0468	COG0751	glycine-tRNA ligase activity
CTN_0469	COG0752	glycyl-tRNA synthetase alpha subunit
CTN_0470	COG0251	oxidation-reduction process
CTN_0471	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CTN_0473	COG0509	glycine decarboxylation via glycine cleavage system
CTN_0474	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CTN_0476	COG0205	6-phosphofructokinase activity
CTN_0477	COG0469	pyruvate kinase activity
CTN_0478	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTN_0481	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CTN_0483	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CTN_0486	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CTN_0487	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CTN_0488	COG0542	response to heat
CTN_0489	COG0037	tRNA processing
CTN_0491	COG0248	Ppx GppA phosphatase
CTN_0492	COG1136	(ABC) transporter
CTN_0493	COG0390	transport system, permease component
CTN_0494	COG2359	stage V sporulation protein S
CTN_0495	COG1120	ATPase activity
CTN_0496	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTN_0498	COG1720	tRNA m6t6A37 methyltransferase activity
CTN_0503	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTN_0505	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_0509	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CTN_0510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CTN_0512	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTN_0513	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CTN_0514	COG1110	DNA topoisomerase II activity
CTN_0515	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
CTN_0516	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
CTN_0518	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CTN_0519	COG0495	leucyl-tRNA aminoacylation
CTN_0520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CTN_0521	COG0285	dihydrofolate synthase activity
CTN_0522	COG0632	four-way junction helicase activity
CTN_0528	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CTN_0529	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CTN_0532	COG1785	Belongs to the alkaline phosphatase family
CTN_0538	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CTN_0539	COG0416	fatty acid biosynthetic process
CTN_0540	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CTN_0541	COG0799	negative regulation of ribosome biogenesis
CTN_0542	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CTN_0543	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CTN_0546	COG3706	GGDEF domain
CTN_0546	COG0745	RESPONSE REGULATOR receiver
CTN_0547	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CTN_0548	COG0512	Glutamine amidotransferase of anthranilate synthase
CTN_0548	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CTN_0549	COG0134	indole-3-glycerol-phosphate synthase activity
CTN_0550	COG0135	phosphoribosylanthranilate isomerase activity
CTN_0551	COG0133	tryptophan synthase activity
CTN_0553	COG0159	tryptophan synthase activity
CTN_0554	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTN_0557	COG1335	isochorismatase
CTN_0558	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTN_0563	COG0745	RESPONSE REGULATOR receiver
CTN_0564	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CTN_0565	COG1121	(ABC) transporter
CTN_0566	COG0803	Belongs to the bacterial solute-binding protein 9 family
CTN_0568	COG1509	lysine 2,3-aminomutase activity
CTN_0569	COG0778	Nitroreductase
CTN_0574	COG1070	Carbohydrate kinase
CTN_0575	COG1129	ABC transporter
CTN_0578	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_0581	COG1940	carbohydrate kinase activity
CTN_0583	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CTN_0589	COG1744	ABC transporter substrate-binding protein PnrA-like
CTN_0591	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CTN_0593	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CTN_0595	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CTN_0605	COG1355	regulation of microtubule-based process
CTN_0606	COG0728	peptidoglycan biosynthetic process
CTN_0609	COG4786	Flagellar basal body rod
CTN_0609	COG4786	Flagellar basal body rod
CTN_0609	COG1256	bacterial-type flagellum assembly
CTN_0609	COG1256	bacterial-type flagellum assembly
CTN_0610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CTN_0611	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CTN_0612	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CTN_0613	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CTN_0614	COG1120	ATPase activity
CTN_0615	COG3458	cephalosporin-C deacetylase activity
CTN_0618	COG4608	Belongs to the ABC transporter superfamily
CTN_0619	COG0444	Belongs to the ABC transporter superfamily
CTN_0620	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_0621	COG0601	transmembrane transport
CTN_0625	COG0246	Mannitol dehydrogenase
CTN_0627	COG0800	Aldolase
CTN_0629	COG1414	Transcriptional regulator
CTN_0630	COG1904	glucuronate isomerase
CTN_0633	COG0675	Transposase, IS605 OrfB family
CTN_0634	COG0601	transmembrane transport
CTN_0635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_0636	COG0444	Belongs to the ABC transporter superfamily
CTN_0637	COG4608	Belongs to the ABC transporter superfamily
CTN_0638	COG4166	transmembrane transport
CTN_0639	COG3661	Belongs to the glycosyl hydrolase 67 family
CTN_0643	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CTN_0643	COG1918	ferrous iron import across plasma membrane
CTN_0645	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CTN_0648	COG1132	(ABC) transporter
CTN_0649	COG0006	proline dipeptidase activity
CTN_0650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CTN_0650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CTN_0651	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CTN_0652	COG1469	GTP cyclohydrolase I activity
CTN_0653	COG0720	synthase
CTN_0654	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_0655	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_0660	COG1653	transport
CTN_0661	COG1175	transmembrane transport
CTN_0662	COG0395	ABC-type sugar transport system, permease component
CTN_0664	COG4166	transmembrane transport
CTN_0665	COG0601	transmembrane transport
CTN_0667	COG4608	Belongs to the ABC transporter superfamily
CTN_0668	COG4608	Belongs to the ABC transporter superfamily
CTN_0672	COG0840	transmembrane signaling receptor activity
CTN_0675	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CTN_0676	COG1993	acr, cog1993
CTN_0677	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CTN_0678	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_0679	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_0680	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTN_0681	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTN_0682	COG1144	Oxidoreductase
CTN_0683	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTN_0684	COG0840	transmembrane signaling receptor activity
CTN_0691	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
CTN_0693	COG4948	Mandelate Racemase Muconate Lactonizing
CTN_0702	COG1353	crispr-associated protein
CTN_0714	COG1518	maintenance of DNA repeat elements
CTN_0715	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CTN_0721	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CTN_0723	COG2813	Specifically methylates the guanine in position
CTN_0724	COG1122	ATPase activity
CTN_0725	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CTN_0726	COG0242	peptide deformylase activity
CTN_0729	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CTN_0730	COG0268	Binds directly to 16S ribosomal RNA
CTN_0732	COG0745	RESPONSE REGULATOR receiver
CTN_0733	COG5002	protein histidine kinase activity
CTN_0736	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTN_0739	COG1713	HD superfamily hydrolase involved in NAD metabolism
CTN_0744	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
CTN_0745	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
CTN_0749	COG0525	valine-tRNA ligase activity
CTN_0750	COG2059	Chromate
CTN_0752	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CTN_0752	COG0519	Catalyzes the synthesis of GMP from XMP
CTN_0753	COG1059	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)
CTN_0754	COG0330	HflC and HflK could
CTN_0755	COG0330	HflC and HflK could
CTN_0757	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CTN_0758	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTN_0758	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CTN_0759	COG0307	riboflavin synthase, alpha
CTN_0760	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTN_0760	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CTN_0764	COG1175	transmembrane transport
CTN_0766	COG0366	Alpha amylase catalytic
CTN_0771	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTN_0772	COG1523	belongs to the glycosyl hydrolase 13 family
CTN_0774	COG1940	carbohydrate kinase activity
CTN_0775	COG1129	ABC transporter
CTN_0776	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_0780	COG1653	transport
CTN_0782	COG2723	6-phospho-beta-galactosidase activity
CTN_0783	COG3459	Glycosyltransferase 36 associated
CTN_0788	COG0395	ABC-type sugar transport system, permease component
CTN_0789	COG1175	transmembrane transport
CTN_0792	COG1418	mRNA catabolic process
CTN_0793	COG2137	regulation of response to DNA damage stimulus
CTN_0794	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CTN_0795	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
CTN_0796	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTN_0800	COG1515	deoxyribonuclease V activity
CTN_0803	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CTN_0804	COG1067	ATP-dependent peptidase activity
CTN_0805	COG2894	cell division
CTN_0807	COG0432	Pfam Uncharacterised protein family UPF0047
CTN_0809	COG1278	Cold shock
CTN_0814	COG0737	Belongs to the 5'-nucleotidase family
CTN_0816	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
CTN_0816	COG0540	Belongs to the ATCase OTCase family
CTN_0817	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
CTN_0819	COG0543	2 iron, 2 sulfur cluster binding
CTN_0820	COG4555	ABC transporter
CTN_0822	COG0419	ATPase involved in DNA repair
CTN_0825	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTN_0826	COG0802	atpase or kinase
CTN_0829	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CTN_0830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CTN_0831	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CTN_0832	COG0193	aminoacyl-tRNA hydrolase activity
CTN_0834	COG3250	beta-galactosidase activity
CTN_0835	COG0481	GTPase activity
CTN_0837	COG0584	glycerophosphoryl diester phosphodiesterase
CTN_0839	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTN_0839	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CTN_0840	COG1406	Chemotaxis phosphatase CheX
CTN_0842	COG0356	it plays a direct role in the translocation of protons across the membrane
CTN_0843	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTN_0844	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CTN_0845	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CTN_0846	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CTN_0847	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CTN_0848	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CTN_0849	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CTN_0850	COG1307	EDD domain protein, DegV family
CTN_0852	COG1530	ribonuclease E activity
CTN_0853	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CTN_0854	COG0528	UMP kinase activity
CTN_0855	COG0477	Major facilitator Superfamily
CTN_0856	COG1827	regulation of RNA biosynthetic process
CTN_0857	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_0860	COG1595	DNA-templated transcription, initiation
CTN_0861	COG3457	Alanine racemase
CTN_0864	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
CTN_0865	COG3706	GGDEF domain
CTN_0866	COG0489	protein tyrosine kinase activity
CTN_0867	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CTN_0868	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CTN_0869	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CTN_0870	COG1278	Cold shock
CTN_0872	COG1185	polyribonucleotide nucleotidyltransferase activity
CTN_0873	COG1376	ErfK ybiS ycfS ynhG family protein
CTN_0874	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CTN_0875	COG1758	RNA polymerase activity
CTN_0876	COG0194	GDP metabolic process
CTN_0877	COG2052	Domain of unknown function (DUF370)
CTN_0878	COG1561	YicC-like family, N-terminal region
CTN_0881	COG0301	tRNA thio-modification
CTN_0884	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CTN_0886	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_0890	COG1368	sulfuric ester hydrolase activity
CTN_0891	COG1368	sulfuric ester hydrolase activity
CTN_0893	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CTN_0894	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CTN_0895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CTN_0897	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CTN_0898	COG1660	Displays ATPase and GTPase activities
CTN_0901	COG1739	Uncharacterized protein family UPF0029
CTN_0903	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CTN_0905	COG1162	GTPase activity
CTN_0906	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CTN_0907	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CTN_0908	COG2153	protein acetylation
CTN_0911	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CTN_0912	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_0916	COG1269	ATP hydrolysis coupled proton transport
CTN_0920	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
CTN_0921	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
CTN_0922	COG1394	ATPase activity, coupled to movement of substances
CTN_0926	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CTN_0928	COG2255	four-way junction helicase activity
CTN_0929	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CTN_0931	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CTN_0932	COG0704	Plays a role in the regulation of phosphate uptake
CTN_0934	COG0305	Participates in initiation and elongation during chromosome replication
CTN_0935	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
CTN_0938	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
CTN_0939	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CTN_0940	COG0647	UMP catabolic process
CTN_0941	COG0667	Aldo Keto reductase
CTN_0942	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
CTN_0944	COG3426	butyrate kinase activity
CTN_0945	COG0280	phosphate acetyltransferase
CTN_0946	COG3426	butyrate kinase activity
CTN_0951	COG0556	nucleotide-excision repair
CTN_0953	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CTN_0955	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTN_0956	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CTN_0957	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CTN_0958	COG1570	exodeoxyribonuclease VII activity
CTN_0959	COG1722	exodeoxyribonuclease VII activity
CTN_0960	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CTN_0964	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
CTN_0966	COG0735	belongs to the Fur family
CTN_0967	COG0195	Participates in both transcription termination and antitermination
CTN_0968	COG0779	Required for maturation of 30S ribosomal subunits
CTN_0970	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CTN_0971	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CTN_0972	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CTN_0973	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CTN_0974	COG2171	N-acyltransferase activity
CTN_0976	COG0019	diaminopimelate decarboxylase activity
CTN_0977	COG1473	amidohydrolase
CTN_0980	COG1323	Belongs to the UPF0348 family
CTN_0981	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CTN_0981	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CTN_0982	COG2738	Putative neutral zinc metallopeptidase
CTN_0984	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CTN_0985	COG1480	7TM receptor with intracellular HD hydrolase
CTN_0986	COG1702	phosphate starvation-inducible protein PhoH
CTN_0988	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CTN_0989	COG0049	tRNA binding
CTN_0990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CTN_0991	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CTN_0992	COG0051	transcription antitermination factor activity, RNA binding
CTN_0993	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CTN_0994	COG0088	Forms part of the polypeptide exit tunnel
CTN_0995	COG0089	rRNA binding
CTN_0996	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CTN_0997	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CTN_0998	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CTN_0999	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CTN_1000	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CTN_1001	COG0255	Belongs to the universal ribosomal protein uL29 family
CTN_1002	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CTN_1003	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CTN_1004	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CTN_1006	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CTN_1007	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CTN_1008	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CTN_1009	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CTN_1010	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CTN_1011	COG1841	ribosomal large subunit assembly
CTN_1012	COG0200	Binds to the 23S rRNA
CTN_1013	COG0201	protein transport
CTN_1015	COG0024	Methionine aminopeptidase
CTN_1016	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CTN_1018	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CTN_1019	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CTN_1020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CTN_1021	COG0202	RNA polymerase activity
CTN_1022	COG0203	ribosomal protein L17
CTN_1023	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CTN_1024	COG1940	carbohydrate kinase activity
CTN_1025	COG1307	EDD domain protein, DegV family
CTN_1027	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CTN_1028	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CTN_1029	COG2313	pseudouridylate synthase activity
CTN_1030	COG0594	ribonuclease P activity
CTN_1031	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CTN_1032	COG0706	membrane insertase activity
CTN_1035	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CTN_1037	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CTN_1038	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
CTN_1039	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CTN_1040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CTN_1041	COG0358	DNA primase activity
CTN_1042	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CTN_1043	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CTN_1044	COG3063	Type IV pilus biogenesis stability protein PilW
CTN_1046	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CTN_1047	COG1160	GTP binding
CTN_1048	COG2183	response to ionizing radiation
CTN_1048	COG0539	negative regulation of cytoplasmic translation
CTN_1049	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CTN_1050	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CTN_1051	COG1366	Belongs to the anti-sigma-factor antagonist family
CTN_1052	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CTN_1053	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CTN_1056	COG1543	Belongs to the glycosyl hydrolase 57 family
CTN_1057	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CTN_1063	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CTN_1065	COG0840	transmembrane signaling receptor activity
CTN_1066	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CTN_1072	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
CTN_1075	COG1213	nucleotidyl transferase
CTN_1075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CTN_1077	COG0719	Fe-S assembly protein
CTN_1078	COG0483	inositol monophosphate 1-phosphatase activity
CTN_1079	COG1621	beta-fructofuranosidase activity
CTN_1082	COG0438	transferase activity, transferring glycosyl groups
CTN_1083	COG2342	PFAM TM1410 hypothetical-related protein
CTN_1087	COG0438	transferase activity, transferring glycosyl groups
CTN_1088	COG3437	response regulator, receiver
CTN_1094	COG1434	Gram-negative-bacterium-type cell wall biogenesis
CTN_1096	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTN_1109	COG1959	2 iron, 2 sulfur cluster binding
CTN_1110	COG1575	Belongs to the MenA family. Type 1 subfamily
CTN_1113	COG2086	electron transfer activity
CTN_1114	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CTN_1115	COG0644	oxidoreductase
CTN_1120	COG1032	radical SAM domain protein
CTN_1122	COG1706	bacterial-type flagellum-dependent cell motility
CTN_1123	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
CTN_1126	COG4786	Flagellar basal body rod
CTN_1128	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CTN_1129	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CTN_1129	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CTN_1130	COG1078	dGTPase activity
CTN_1132	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTN_1133	COG3872	metal-dependent enzyme
CTN_1134	COG2078	PFAM AMMECR1 domain protein
CTN_1136	COG1477	protein flavinylation
CTN_1139	COG0424	maF-like protein
CTN_1140	COG2003	Belongs to the UPF0758 family
CTN_1141	COG1418	mRNA catabolic process
CTN_1142	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CTN_1144	COG0343	queuine tRNA-ribosyltransferase activity
CTN_1146	COG0668	transmembrane transport
CTN_1147	COG1254	Belongs to the acylphosphatase family
CTN_1148	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CTN_1149	COG0228	four-way junction DNA binding
CTN_1150	COG1837	Belongs to the UPF0109 family
CTN_1151	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CTN_1152	COG0336	Belongs to the RNA methyltransferase TrmD family
CTN_1153	COG4752	Belongs to the RNA methyltransferase TrmD family
CTN_1154	COG0335	large ribosomal subunit rRNA binding
CTN_1155	COG0681	Belongs to the peptidase S26 family
CTN_1157	COG0101	tRNA pseudouridine synthase activity
CTN_1159	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CTN_1161	COG0653	protein targeting
CTN_1162	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CTN_1163	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CTN_1168	COG1040	competence protein
CTN_1169	COG2379	hydroxypyruvate reductase
CTN_1171	COG2199	diguanylate cyclase activity
CTN_1178	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CTN_1179	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CTN_1180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CTN_1181	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CTN_1182	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CTN_1183	COG0165	Argininosuccinate lyase
CTN_1184	COG0137	argininosuccinate synthase activity
CTN_1190	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CTN_1191	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CTN_1192	COG0233	cytoplasmic translational termination
CTN_1193	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CTN_1194	COG0575	Belongs to the CDS family
CTN_1195	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CTN_1197	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CTN_1198	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CTN_1200	COG0542	response to heat
CTN_1202	COG2226	methyltransferase
CTN_1203	COG0742	ribosomal rna small subunit methyltransferase
CTN_1204	COG0237	dephospho-CoA kinase activity
CTN_1206	COG0166	Belongs to the GPI family
CTN_1207	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CTN_1212	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CTN_1213	COG1177	transmembrane transport
CTN_1214	COG1176	ABC-type spermidine putrescine transport system, permease component I
CTN_1215	COG3842	ATPase activity
CTN_1216	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
CTN_1217	COG0406	alpha-ribazole phosphatase activity
CTN_1219	COG0822	iron-sulfur transferase activity
CTN_1220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CTN_1221	COG1372	Participates in initiation and elongation during chromosome replication
CTN_1221	COG0719	Fe-S assembly protein
CTN_1222	COG0719	Fe-S assembly protein
CTN_1223	COG0396	ATPase activity
CTN_1225	COG1677	Flagellar hook-basal body complex protein FliE
CTN_1226	COG1558	bacterial-type flagellum-dependent cell motility
CTN_1227	COG1815	bacterial-type flagellum-dependent cell motility
CTN_1228	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CTN_1230	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CTN_1231	COG0745	RESPONSE REGULATOR receiver
CTN_1232	COG3852	Histidine kinase
CTN_1237	COG0517	IMP dehydrogenase activity
CTN_1237	COG0516	GMP reductase activity
CTN_1240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CTN_1241	COG2267	carboxylic ester hydrolase activity
CTN_1242	COG0628	permease
CTN_1244	COG0517	IMP dehydrogenase activity
CTN_1244	COG0516	GMP reductase activity
CTN_1245	COG0612	Peptidase, M16
CTN_1246	COG1185	polyribonucleotide nucleotidyltransferase activity
CTN_1247	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CTN_1256	COG1132	(ABC) transporter
CTN_1258	COG4555	ABC transporter
CTN_1261	COG0641	radical SAM
CTN_1264	COG1131	(ABC) transporter
CTN_1267	COG1598	PFAM Uncharacterised protein family UPF0150
CTN_1268	COG1132	(ABC) transporter
CTN_1269	COG1132	(ABC) transporter
CTN_1272	COG0457	Tetratricopeptide repeat
CTN_1273	COG1598	PFAM Uncharacterised protein family UPF0150
CTN_1274	COG1598	PFAM Uncharacterised protein family UPF0150
CTN_1275	COG1132	(ABC) transporter
CTN_1280	COG4555	ABC transporter
CTN_1283	COG0667	Aldo Keto reductase
CTN_1286	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CTN_1289	COG0662	Cupin 2, conserved barrel domain protein
CTN_1290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CTN_1291	COG1486	melibiose metabolic process
CTN_1294	COG1193	negative regulation of DNA recombination
CTN_1296	COG3842	ATPase activity
CTN_1299	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CTN_1300	COG0154	amidase activity
CTN_1303	COG0626	cystathionine gamma-synthase activity
CTN_1304	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CTN_1309	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CTN_1311	COG0573	inorganic phosphate transmembrane transporter activity
CTN_1312	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CTN_1313	COG0704	Plays a role in the regulation of phosphate uptake
CTN_1314	COG0745	RESPONSE REGULATOR receiver
CTN_1315	COG5002	protein histidine kinase activity
CTN_1318	COG1132	(ABC) transporter
CTN_1319	COG0436	Aminotransferase
CTN_1320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CTN_1321	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CTN_1321	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CTN_1323	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CTN_1324	COG0151	Belongs to the GarS family
CTN_1325	COG0138	bifunctional purine biosynthesis protein purh
CTN_1326	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CTN_1327	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CTN_1328	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTN_1329	COG0047	phosphoribosylformylglycinamidine synthase activity
CTN_1330	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CTN_1331	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CTN_1333	COG0012	GTP binding
CTN_1335	COG0210	DNA helicase
CTN_1340	COG3842	ATPase activity
CTN_1341	COG0383	alpha-mannosidase activity
CTN_1342	COG0438	transferase activity, transferring glycosyl groups
CTN_1343	COG0463	Glycosyl transferase, family 2
CTN_1346	COG2152	Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose
CTN_1347	COG1940	carbohydrate kinase activity
CTN_1348	COG4166	transmembrane transport
CTN_1349	COG0601	transmembrane transport
CTN_1350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_1351	COG0444	Belongs to the ABC transporter superfamily
CTN_1352	COG4608	Belongs to the ABC transporter superfamily
CTN_1355	COG0649	NAD binding
CTN_1356	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTN_1356	COG0649	NAD binding
CTN_1357	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CTN_1360	COG0651	ATP synthesis coupled electron transport
CTN_1361	COG1006	Multisubunit Na H antiporter MnhC subunit
CTN_1362	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CTN_1362	COG2111	Na H antiporter
CTN_1365	COG2212	antiporter activity
CTN_1366	COG1863	multisubunit Na H antiporter MnhE subunit
CTN_1367	COG2182	Extracellular solute-binding protein
CTN_1368	COG1175	transmembrane transport
CTN_1369	COG3833	ABC-type maltose transport systems, permease component
CTN_1374	COG0395	ABC-type sugar transport system, permease component
CTN_1376	COG0601	transmembrane transport
CTN_1377	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CTN_1380	COG0444	Belongs to the ABC transporter superfamily
CTN_1381	COG3250	beta-galactosidase activity
CTN_1382	COG3250	beta-galactosidase activity
CTN_1383	COG3345	alpha-galactosidase
CTN_1384	COG1085	galactose-1-phosphate uridylyltransferase
CTN_1385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CTN_1387	COG2199	diguanylate cyclase activity
CTN_1389	COG0628	permease
CTN_1391	COG1803	Methylglyoxal synthase
CTN_1393	COG0667	Aldo Keto reductase
CTN_1394	COG1196	nuclear chromosome segregation
CTN_1395	COG0494	nUDIX hydrolase
CTN_1399	COG1011	Hydrolase
CTN_1403	COG1151	hydroxylamine reductase activity
CTN_1406	COG1028	Short-chain dehydrogenase reductase Sdr
CTN_1407	COG0058	SHG alpha-glucan phosphorylase activity
CTN_1409	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTN_1410	COG1013	pyruvate-flavodoxin oxidoreductase activity
CTN_1411	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTN_1411	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTN_1412	COG3706	GGDEF domain
CTN_1413	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CTN_1414	COG2239	Acts as a magnesium transporter
CTN_1419	COG1983	PspC domain protein
CTN_1420	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
CTN_1421	COG0363	glucosamine-6-phosphate deaminase activity
CTN_1423	COG0444	Belongs to the ABC transporter superfamily
CTN_1424	COG4608	Belongs to the ABC transporter superfamily
CTN_1425	COG0747	negative chemotaxis
CTN_1429	COG0785	Cytochrome C biogenesis protein
CTN_1432	COG0411	ABC transporter
CTN_1434	COG0559	Belongs to the binding-protein-dependent transport system permease family
CTN_1438	COG0714	Associated with various cellular activities
CTN_1439	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CTN_1440	COG0280	phosphate acetyltransferase
CTN_1441	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CTN_1447	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CTN_1462	COG0651	ATP synthesis coupled electron transport
CTN_1463	COG1006	Multisubunit Na H antiporter MnhC subunit
CTN_1464	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CTN_1465	COG0571	ribonuclease III activity
CTN_1468	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CTN_1470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CTN_1471	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CTN_1472	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CTN_1474	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CTN_1475	COG0018	arginyl-trna synthetase
CTN_1478	COG0124	histidyl-tRNA synthetase
CTN_1484	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTN_1484	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTN_1485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CTN_1486	COG1371	PFAM Archease protein family (DUF101 UPF0211)
CTN_1487	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CTN_1489	COG0698	ribose 5-phosphate isomerase
CTN_1490	COG2264	protein methyltransferase activity
CTN_1496	COG1070	Carbohydrate kinase
CTN_1498	COG4952	isomerase
CTN_1500	COG1349	DNA-binding transcription factor activity
CTN_1501	COG1486	melibiose metabolic process
CTN_1502	COG0747	negative chemotaxis
CTN_1505	COG3250	beta-galactosidase activity
CTN_1508	COG2359	stage V sporulation protein S
CTN_1510	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CTN_1511	COG1324	tolerance protein
CTN_1512	COG1611	Belongs to the LOG family
CTN_1515	COG1596	polysaccharide export
CTN_1515	COG1555	photosystem II stabilization
CTN_1518	COG1363	Peptidase, m42
CTN_1520	COG0850	regulation of cytokinetic process
CTN_1523	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CTN_1524	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CTN_1525	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CTN_1526	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CTN_1527	COG0131	Imidazoleglycerol-phosphate dehydratase
CTN_1528	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CTN_1529	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CTN_1530	COG0107	imidazoleglycerol-phosphate synthase activity
CTN_1531	COG0140	phosphoribosyl-ATP diphosphatase activity
CTN_1531	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CTN_1532	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CTN_1533	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CTN_1533	COG0662	Cupin 2, conserved barrel domain protein
CTN_1537	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
CTN_1538	COG1131	(ABC) transporter
CTN_1539	COG1131	(ABC) transporter
CTN_1540	COG2211	Major facilitator Superfamily
CTN_1543	COG0395	ABC-type sugar transport system, permease component
CTN_1544	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CTN_1546	COG2721	sulfolactate sulfo-lyase activity
CTN_1548	COG1012	belongs to the aldehyde dehydrogenase family
CTN_1550	COG1501	Belongs to the glycosyl hydrolase 31 family
CTN_1554	COG0840	transmembrane signaling receptor activity
CTN_1558	COG2814	Major facilitator Superfamily
CTN_1563	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CTN_1569	COG0656	L-ascorbic acid biosynthetic process
CTN_1571	COG0667	Aldo Keto reductase
CTN_1572	COG2207	Transcriptional regulator
CTN_1578	COG1895	HEPN domain
CTN_1579	COG0640	Transcriptional regulator
CTN_1587	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CTN_1591	COG3234	Protein of unknown function (DUF1175)
CTN_1592	COG3234	Protein of unknown function (DUF1175)
CTN_1594	COG2373	Large extracellular alpha-helical protein
CTN_1595	COG0425	Belongs to the sulfur carrier protein TusA family
CTN_1596	COG2391	methyltransferase activity
CTN_1600	COG0425	Belongs to the sulfur carrier protein TusA family
CTN_1604	COG0840	transmembrane signaling receptor activity
CTN_1605	COG3706	GGDEF domain
CTN_1609	COG4974	Belongs to the 'phage' integrase family
CTN_1610	COG1606	tRNA processing
CTN_1611	COG1691	(AIR) carboxylase
CTN_1612	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CTN_1615	COG1704	LemA family
CTN_1616	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CTN_1617	COG1869	D-ribose catabolic process
CTN_1618	COG1879	ABC-type sugar transport system periplasmic component
CTN_1620	COG1129	ABC transporter
CTN_1621	COG1172	Belongs to the binding-protein-dependent transport system permease family
CTN_1622	COG3959	Transketolase, thiamine diphosphate binding domain
CTN_1623	COG3958	Transketolase
CTN_1624	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CTN_1633	COG0174	glutamine synthetase
CTN_1637	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CTN_1640	COG0402	S-adenosylhomocysteine deaminase activity
CTN_1641	COG2239	Acts as a magnesium transporter
CTN_1642	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CTN_1646	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CTN_1647	COG3864	Putative metallopeptidase domain
CTN_1649	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CTN_1650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CTN_1653	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CTN_1653	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CTN_1657	COG0840	transmembrane signaling receptor activity
CTN_1658	COG0306	phosphate transporter
CTN_1660	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CTN_1661	COG1392	Phosphate transport regulator
CTN_1662	COG3956	TIGRFAM MazG family protein
CTN_1664	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CTN_1665	COG1684	flagellar biosynthetic protein fliR
CTN_1666	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTN_1667	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CTN_1668	COG1419	protein localization to endoplasmic reticulum
CTN_1669	COG0455	bacterial-type flagellum organization
CTN_1671	COG1776	CheC inhibitor of MCP methylation
CTN_1672	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
CTN_1673	COG1191	sigma factor activity
CTN_1678	COG2359	stage V sporulation protein S
CTN_1680	COG0297	glycogen (starch) synthase activity
CTN_1681	COG0297	glycogen (starch) synthase activity
CTN_1683	COG1968	undecaprenyl-diphosphatase activity
CTN_1684	COG2239	Acts as a magnesium transporter
CTN_1685	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CTN_1686	COG0750	zinc metalloprotease
CTN_1687	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CTN_1689	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CTN_1690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CTN_1693	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CTN_1695	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CTN_1696	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
CTN_1697	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CTN_1697	COG0674	pyruvate-flavodoxin oxidoreductase activity
CTN_1698	COG0148	phosphopyruvate hydratase activity
CTN_1699	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CTN_1701	COG1214	PFAM Peptidase M22, glycoprotease
CTN_1702	COG0542	response to heat
CTN_1703	COG0275	rRNA processing
CTN_1705	COG0768	penicillin binding
CTN_1706	COG0492	ferredoxin-NADP+ reductase activity
CTN_1711	COG1234	tRNA 3'-trailer cleavage
CTN_1712	COG0359	binds to the 23S rRNA
CTN_1714	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTN_1715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CTN_1716	COG1862	Preprotein translocase
CTN_1718	COG0196	riboflavin kinase activity
CTN_1719	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CTN_1720	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CTN_1721	COG1639	'signal transduction protein
CTN_1722	COG5002	protein histidine kinase activity
CTN_1723	COG0009	L-threonylcarbamoyladenylate synthase
CTN_1724	COG1420	regulation of RNA biosynthetic process
CTN_1725	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CTN_1726	COG0484	heat shock protein binding
CTN_1727	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTN_1728	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CTN_1729	COG0295	cytidine deaminase activity
CTN_1730	COG4535	Mg2 and Co2 transporter CorC
CTN_1731	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CTN_1733	COG2201	protein-glutamate methylesterase activity
CTN_1737	COG0772	Belongs to the SEDS family
CTN_1739	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CTN_1740	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CTN_1741	COG0849	cell division
CTN_1743	COG0187	DNA topoisomerase II activity
CTN_1745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CTN_1746	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CTN_1749	COG3842	ATPase activity
CTN_1751	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CTN_1753	COG1309	transcriptional regulator
CTN_1754	COG0072	phenylalanine-tRNA ligase activity
CTN_1754	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CTN_1755	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CTN_1756	COG1979	alcohol dehydrogenase
CTN_1758	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CTN_1762	COG0534	Mate efflux family protein
CTN_1765	COG0395	ABC-type sugar transport system, permease component
CTN_1769	COG1472	Belongs to the glycosyl hydrolase 3 family
CTN_1771	COG0450	alkyl hydroperoxide reductase
CTN_1773	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CTN_1774	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CTN_1775	COG0504	CTP synthase activity
CTN_1776	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CTN_1777	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CTN_1778	COG2070	2-Nitropropane dioxygenase
CTN_1779	COG1268	BioY protein
CTN_1780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CTN_1781	COG2045	Belongs to the ComB family
CTN_1785	COG1131	(ABC) transporter
CTN_1786	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
CTN_1787	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CTN_1788	COG1992	Thiamine-phosphate synthase
CTN_1788	COG0351	phosphomethylpyrimidine kinase
CTN_1790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CTN_1791	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
CTN_1793	COG1659	Linocin_M18 bacteriocin protein
CTN_1802	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CTN_1805	COG1774	PSP1 C-terminal conserved region
CTN_1806	COG0470	DNA polymerase III
CTN_1808	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CTN_1809	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
CTN_1810	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CTN_1812	COG1131	(ABC) transporter
CTN_1814	COG1129	ABC transporter
CTN_1816	COG0393	Putative heavy-metal-binding
CTN_1817	COG0052	Belongs to the universal ribosomal protein uS2 family
CTN_1820	COG1181	Belongs to the D-alanine--D-alanine ligase family
CTN_1823	COG0457	Tetratricopeptide repeat
CTN_1823	COG0463	Glycosyl transferase, family 2
CTN_1824	COG2264	protein methyltransferase activity
CTN_1826	COG0426	domain, Protein
CTN_1828	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CTN_1829	COG2226	methyltransferase
CTN_1830	COG1486	melibiose metabolic process
CTN_1831	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTN_1836	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CTN_1837	COG0793	Belongs to the peptidase S41A family
CTN_1840	COG0438	transferase activity, transferring glycosyl groups
CTN_1842	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
CTN_1843	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CTN_1844	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CTN_1845	COG2199	diguanylate cyclase activity
CTN_1845	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CTN_1848	COG1482	cell wall glycoprotein biosynthetic process
CTN_1850	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
CTN_1853	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CTN_1854	COG1490	D-aminoacyl-tRNA deacylase activity
CTN_1855	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CTN_1857	COG0312	modulator of DNA gyrase
CTN_1858	COG0312	modulator of DNA gyrase
CTN_1862	COG0557	exoribonuclease II activity
CTN_1863	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CTN_1864	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CTN_1865	COG0215	cysteine-tRNA ligase activity
CTN_1866	COG0835	chemotaxis
CTN_1867	COG0511	ligase activity, forming carbon-carbon bonds
CTN_1869	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CTN_1876	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CTN_1877	COG0095	Lipoate-protein ligase
CTN_1878	COG0357	Ribosomal RNA small subunit methyltransferase G
CTN_1881	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CTN_1882	COG1058	Belongs to the CinA family
CTN_1882	COG1546	Belongs to the CinA family
CTN_1883	COG2198	Histidine kinase
CTN_1883	COG0643	Histidine kinase
CTN_1884	COG0835	chemotaxis
CTN_1885	COG2201	protein-glutamate methylesterase activity
CTN_1887	COG1338	Plays a role in the flagellum-specific transport system
CTN_1890	COG0740	serine-type endopeptidase activity
CTN_1891	COG0544	peptidyl-prolyl cis-trans isomerase activity
CTN_1893	COG0736	holo-[acyl-carrier-protein] synthase activity
CTN_1896	COG0149	triose-phosphate isomerase activity
CTN_1896	COG0126	phosphoglycerate kinase activity
CTN_1897	COG0149	triose-phosphate isomerase activity
CTN_1897	COG0126	phosphoglycerate kinase activity
CTN_1898	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CTN_1899	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CTN_1900	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CTN_1906	COG1776	CheC inhibitor of MCP methylation
CTN_1906	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTN_1907	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CTN_1909	COG1360	Flagellar Motor Protein
CTN_1911	COG1582	Flagellar protein (FlbD)
CTN_1919	COG0084	hydrolase, TatD family'
CTN_1920	COG1045	serine acetyltransferase
CTN_1921	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CTN_1924	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CTN_1926	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
CTN_1927	COG1773	rubredoxin
CTN_1928	COG2033	superoxide reductase activity
CTN_1929	COG1592	Rubrerythrin