locus-tag	class	description
TTHT_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TTHT_0002	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
TTHT_0003	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TTHT_0005	COG2333	competence protein COMEC
TTHT_0005	COG0658	competence protein
TTHT_0006	COG4818	TM2 domain
TTHT_0007	COG0183	Belongs to the thiolase family
TTHT_0008	COG1024	Enoyl-CoA hydratase
TTHT_0008	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_0012	COG1595	DNA-templated transcription, initiation
TTHT_0015	COG1420	regulation of RNA biosynthetic process
TTHT_0016	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TTHT_0017	COG0443	Heat shock 70 kDa protein
TTHT_0030	COG2165	general secretion pathway protein
TTHT_0031	COG1139	Iron-sulfur cluster binding protein
TTHT_0036	COG2244	polysaccharide biosynthetic process
TTHT_0038	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHT_0040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHT_0042	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHT_0043	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
TTHT_0044	COG3481	metal-dependent phosphohydrolase, HD sub domain
TTHT_0046	COG1324	tolerance protein
TTHT_0047	COG0406	alpha-ribazole phosphatase activity
TTHT_0048	COG0018	arginyl-trna synthetase
TTHT_0049	COG1597	lipid kinase activity
TTHT_0055	COG0482	sulfurtransferase activity
TTHT_0057	COG3956	TIGRFAM MazG family protein
TTHT_0058	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TTHT_0061	COG0792	nuclease activity
TTHT_0062	COG3051	citrate lyase alpha subunit
TTHT_0063	COG0012	GTP binding
TTHT_0066	COG1811	Na channel or pump
TTHT_0068	COG1773	rubredoxin
TTHT_0070	COG1131	(ABC) transporter
TTHT_0073	COG2195	Cleaves the N-terminal amino acid of tripeptides
TTHT_0076	COG4770	biotin carboxylase activity
TTHT_0077	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TTHT_0081	COG0745	RESPONSE REGULATOR receiver
TTHT_0084	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTHT_0094	COG0739	heme binding
TTHT_0095	COG0653	protein targeting
TTHT_0096	COG0517	IMP dehydrogenase activity
TTHT_0096	COG0516	GMP reductase activity
TTHT_0097	COG0811	peptide transport
TTHT_0098	COG0848	biopolymer transport protein
TTHT_0100	COG2385	sporulation resulting in formation of a cellular spore
TTHT_0100	COG2385	sporulation resulting in formation of a cellular spore
TTHT_0101	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TTHT_0104	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TTHT_0104	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TTHT_0109	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TTHT_0111	COG1956	GAF domain-containing protein
TTHT_0115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TTHT_0116	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TTHT_0118	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TTHT_0119	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TTHT_0120	COG0072	phenylalanine-tRNA ligase activity
TTHT_0123	COG1418	mRNA catabolic process
TTHT_0124	COG1692	metallophosphoesterase
TTHT_0126	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TTHT_0129	COG3158	transport of potassium into the cell
TTHT_0130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TTHT_0130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TTHT_0131	COG4221	oxidoreductase activity
TTHT_0133	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TTHT_0135	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TTHT_0140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTHT_0142	COG1760	l-serine dehydratase
TTHT_0144	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
TTHT_0150	COG2204	response regulator
TTHT_0151	COG3852	Histidine kinase
TTHT_0156	COG2217	Heavy metal translocating P-type atpase
TTHT_0161	COG0318	PFAM AMP-dependent synthetase and ligase
TTHT_0167	COG2985	domain, Protein
TTHT_0167	COG0490	domain, Protein
TTHT_0168	COG1131	(ABC) transporter
TTHT_0172	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TTHT_0180	COG1518	maintenance of DNA repeat elements
TTHT_0181	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TTHT_0191	COG0297	glycogen (starch) synthase activity
TTHT_0193	COG1543	Belongs to the glycosyl hydrolase 57 family
TTHT_0194	COG3328	transposase activity
TTHT_0198	COG3706	GGDEF domain
TTHT_0199	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TTHT_0200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TTHT_0206	COG0489	protein tyrosine kinase activity
TTHT_0210	COG0179	Fumarylacetoacetate (FAA) hydrolase
TTHT_0217	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TTHT_0219	COG0737	Belongs to the 5'-nucleotidase family
TTHT_0220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TTHT_0224	COG0484	heat shock protein binding
TTHT_0225	COG0631	protein serine/threonine phosphatase activity
TTHT_0234	COG0006	proline dipeptidase activity
TTHT_0236	COG0511	ligase activity, forming carbon-carbon bonds
TTHT_0237	COG0439	Biotin carboxylase
TTHT_0239	COG2165	general secretion pathway protein
TTHT_0242	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
TTHT_0243	COG0196	riboflavin kinase activity
TTHT_0244	COG1652	LysM domain
TTHT_0246	COG0617	tRNA 3'-terminal CCA addition
TTHT_0246	COG3620	sequence-specific DNA binding
TTHT_0246	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TTHT_0247	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
TTHT_0248	COG0045	succinate-CoA ligase (ADP-forming) activity
TTHT_0249	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TTHT_0251	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTHT_0251	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHT_0252	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHT_0254	COG0105	UTP biosynthetic process
TTHT_0256	COG1027	Aspartate ammonia-lyase
TTHT_0257	COG0612	Peptidase, M16
TTHT_0260	COG0515	serine threonine protein kinase
TTHT_0260	COG2815	serine threonine protein kinase
TTHT_0264	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
TTHT_0266	COG0432	Pfam Uncharacterised protein family UPF0047
TTHT_0269	COG5002	protein histidine kinase activity
TTHT_0273	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_0275	COG0326	Molecular chaperone. Has ATPase activity
TTHT_0277	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TTHT_0280	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
TTHT_0282	COG1690	Belongs to the RtcB family
TTHT_0283	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TTHT_0285	COG0561	phosphatase activity
TTHT_0286	COG0010	Belongs to the arginase family
TTHT_0288	COG3290	protein histidine kinase activity
TTHT_0290	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTHT_0292	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TTHT_0294	COG3599	regulation of cell shape
TTHT_0297	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TTHT_0298	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TTHT_0301	COG0463	Glycosyl transferase, family 2
TTHT_0302	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TTHT_0303	COG0509	glycine decarboxylation via glycine cleavage system
TTHT_0304	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHT_0305	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TTHT_0306	COG2309	aminopeptidase activity
TTHT_0307	COG3177	Filamentation induced by cAMP protein fic
TTHT_0308	COG3608	succinylglutamate desuccinylase aspartoacylase
TTHT_0308	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
TTHT_0314	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TTHT_0316	COG0228	four-way junction DNA binding
TTHT_0317	COG1837	Belongs to the UPF0109 family
TTHT_0318	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TTHT_0319	COG0336	Belongs to the RNA methyltransferase TrmD family
TTHT_0320	COG4752	Belongs to the RNA methyltransferase TrmD family
TTHT_0321	COG0335	large ribosomal subunit rRNA binding
TTHT_0322	COG0544	peptidyl-prolyl cis-trans isomerase activity
TTHT_0323	COG0740	serine-type endopeptidase activity
TTHT_0324	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TTHT_0325	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTHT_0326	COG0218	Necessary for normal cell division and for the maintenance of normal septation
TTHT_0327	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TTHT_0338	COG0681	Belongs to the peptidase S26 family
TTHT_0339	COG0500	methyltransferase
TTHT_0340	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TTHT_0345	COG1028	Short-chain dehydrogenase reductase Sdr
TTHT_0348	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TTHT_0353	COG0047	phosphoribosylformylglycinamidine synthase activity
TTHT_0355	COG1067	ATP-dependent peptidase activity
TTHT_0356	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TTHT_0357	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TTHT_0360	COG1271	oxidase subunit
TTHT_0361	COG1294	oxidase, subunit
TTHT_0363	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TTHT_0364	COG0459	protein refolding
TTHT_0367	COG5002	protein histidine kinase activity
TTHT_0368	COG2204	response regulator
TTHT_0373	COG1214	PFAM Peptidase M22, glycoprotease
TTHT_0374	COG0456	acetyltransferase
TTHT_0375	COG2431	L-lysine efflux transmembrane transporter activity
TTHT_0381	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TTHT_0383	COG0463	Glycosyl transferase, family 2
TTHT_0385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TTHT_0386	COG0071	Belongs to the small heat shock protein (HSP20) family
TTHT_0391	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TTHT_0393	COG1546	Belongs to the CinA family
TTHT_0393	COG1058	Belongs to the CinA family
TTHT_0399	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TTHT_0400	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
TTHT_0409	COG1074	ATP-dependent DNA helicase activity
TTHT_0412	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TTHT_0416	COG1162	GTPase activity
TTHT_0417	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTHT_0418	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TTHT_0419	COG0805	protein transport
TTHT_0423	COG0509	glycine decarboxylation via glycine cleavage system
TTHT_0424	COG3064	Membrane
TTHT_0424	COG0437	4 iron, 4 sulfur cluster binding
TTHT_0425	COG5557	Pfam Polysulphide reductase, NrfD
TTHT_0426	COG5002	protein histidine kinase activity
TTHT_0427	COG2204	response regulator
TTHT_0431	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TTHT_0432	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TTHT_0433	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TTHT_0435	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTHT_0436	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TTHT_0437	COG0799	negative regulation of ribosome biogenesis
TTHT_0438	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TTHT_0440	COG0217	transcriptional regulatory protein
TTHT_0441	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TTHT_0443	COG0322	excinuclease ABC activity
TTHT_0445	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_0448	COG1881	PFAM PEBP family protein
TTHT_0454	COG3852	Histidine kinase
TTHT_0455	COG2204	response regulator
TTHT_0457	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TTHT_0461	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTHT_0462	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TTHT_0465	COG1027	Aspartate ammonia-lyase
TTHT_0466	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTHT_0470	COG3706	GGDEF domain
TTHT_0474	COG2172	sigma factor antagonist activity
TTHT_0476	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TTHT_0476	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TTHT_0480	COG0247	lactate metabolic process
TTHT_0480	COG2181	nitrate reductase activity
TTHT_0485	COG2264	protein methyltransferase activity
TTHT_0488	COG0330	HflC and HflK could
TTHT_0492	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TTHT_0493	COG0688	phosphatidylethanolamine metabolic process
TTHT_0494	COG3359	exonuclease
TTHT_0498	COG3706	GGDEF domain
TTHT_0499	COG4956	integral membrane protein (PIN domain superfamily)
TTHT_0501	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TTHT_0502	COG0166	Belongs to the GPI family
TTHT_0504	COG0444	Belongs to the ABC transporter superfamily
TTHT_0505	COG4608	Belongs to the ABC transporter superfamily
TTHT_0506	COG3706	GGDEF domain
TTHT_0508	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHT_0509	COG0066	3-isopropylmalate dehydratase activity
TTHT_0510	COG0745	RESPONSE REGULATOR receiver
TTHT_0514	COG1193	negative regulation of DNA recombination
TTHT_0515	COG0546	phosphoglycolate phosphatase activity
TTHT_0517	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHT_0517	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TTHT_0518	COG0549	Belongs to the carbamate kinase family
TTHT_0519	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TTHT_0523	COG1392	Phosphate transport regulator
TTHT_0524	COG0306	phosphate transporter
TTHT_0529	COG0737	Belongs to the 5'-nucleotidase family
TTHT_0529	COG4085	toxin activity
TTHT_0529	COG1525	nuclease
TTHT_0532	COG1012	belongs to the aldehyde dehydrogenase family
TTHT_0533	COG1115	amino acid carrier protein
TTHT_0534	COG0667	Aldo Keto reductase
TTHT_0536	COG0616	signal peptide processing
TTHT_0539	COG0768	penicillin binding
TTHT_0540	COG0772	Belongs to the SEDS family
TTHT_0542	COG0613	PHP domain protein
TTHT_0549	COG0463	Glycosyl transferase, family 2
TTHT_0554	COG0437	4 iron, 4 sulfur cluster binding
TTHT_0558	COG1704	LemA family
TTHT_0563	COG1136	(ABC) transporter
TTHT_0564	COG0542	response to heat
TTHT_0565	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TTHT_0567	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TTHT_0568	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TTHT_0568	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TTHT_0569	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TTHT_0570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTHT_0572	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TTHT_0573	COG5505	Protein of unknown function (DUF819)
TTHT_0575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHT_0576	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
TTHT_0576	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TTHT_0578	COG0268	Binds directly to 16S ribosomal RNA
TTHT_0579	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TTHT_0580	COG1923	regulation of RNA biosynthetic process
TTHT_0581	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTHT_0588	COG0163	prenyltransferase activity
TTHT_0589	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TTHT_0590	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTHT_0591	COG1519	Transferase
TTHT_0591	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TTHT_0592	COG1663	tetraacyldisaccharide 4'-kinase activity
TTHT_0593	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TTHT_0598	COG1921	L-seryl-tRNASec selenium transferase activity
TTHT_0601	COG0254	rRNA binding
TTHT_0602	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TTHT_0603	COG2890	protein-(glutamine-N5) methyltransferase activity
TTHT_0604	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TTHT_0605	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TTHT_0605	COG2199	diguanylate cyclase activity
TTHT_0608	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TTHT_0609	COG0540	Belongs to the ATCase OTCase family
TTHT_0610	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TTHT_0611	COG2067	long-chain fatty acid transport protein
TTHT_0612	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TTHT_0613	COG4656	Part of a membrane complex involved in electron transport
TTHT_0616	COG2201	protein-glutamate methylesterase activity
TTHT_0617	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
TTHT_0619	COG2198	Histidine kinase
TTHT_0619	COG0643	Histidine kinase
TTHT_0621	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TTHT_0622	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TTHT_0627	COG0758	DNA mediated transformation
TTHT_0628	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TTHT_0629	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
TTHT_0636	COG1960	acyl-CoA dehydrogenase activity
TTHT_0637	COG1960	acyl-CoA dehydrogenase activity
TTHT_0638	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TTHT_0639	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
TTHT_0640	COG0058	SHG alpha-glucan phosphorylase activity
TTHT_0642	COG1183	phosphatidylcholine synthase activity
TTHT_0644	COG1366	Belongs to the anti-sigma-factor antagonist family
TTHT_0646	COG1297	OPT oligopeptide transporter protein
TTHT_0649	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TTHT_0650	COG0037	tRNA processing
TTHT_0651	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TTHT_0653	COG1100	Small GTP-binding protein
TTHT_0656	COG1538	Outer membrane efflux protein
TTHT_0660	COG3858	chitin binding
TTHT_0660	COG1388	LysM domain
TTHT_0662	COG0284	orotidine-5'-phosphate decarboxylase activity
TTHT_0663	COG0167	dihydroorotate dehydrogenase activity
TTHT_0666	COG0009	L-threonylcarbamoyladenylate synthase
TTHT_0667	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TTHT_0668	COG3314	Sporulation integral membrane protein YlbJ
TTHT_0671	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_0671	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_0671	COG1703	isobutyryl-CoA mutase activity
TTHT_0675	COG2088	sporulation resulting in formation of a cellular spore
TTHT_0676	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TTHT_0677	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TTHT_0678	COG0193	aminoacyl-tRNA hydrolase activity
TTHT_0679	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
TTHT_0680	COG0360	Binds together with S18 to 16S ribosomal RNA
TTHT_0681	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TTHT_0684	COG1442	glycosyl transferase family 8
TTHT_0684	COG1216	Glycosyl transferase, family 2
TTHT_0687	COG0601	transmembrane transport
TTHT_0689	COG2183	response to ionizing radiation
TTHT_0697	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TTHT_0702	COG1131	(ABC) transporter
TTHT_0703	COG1725	Transcriptional regulator
TTHT_0704	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TTHT_0706	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TTHT_0707	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_0708	COG0113	porphobilinogen synthase activity
TTHT_0710	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
TTHT_0711	COG0714	Associated with various cellular activities
TTHT_0716	COG2304	oxidoreductase activity
TTHT_0722	COG0457	Tetratricopeptide repeat
TTHT_0726	COG0442	prolyl-tRNA aminoacylation
TTHT_0728	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TTHT_0730	COG0825	malonyl-CoA metabolic process
TTHT_0734	COG1137	ATPase activity
TTHT_0735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TTHT_0736	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TTHT_0738	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
TTHT_0740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHT_0741	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TTHT_0742	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_0744	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TTHT_0746	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TTHT_0759	COG4964	Belongs to the GSP D family
TTHT_0765	COG1716	ATPase activity
TTHT_0772	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TTHT_0773	COG3118	belongs to the thioredoxin family
TTHT_0774	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TTHT_0774	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TTHT_0777	COG0742	ribosomal rna small subunit methyltransferase
TTHT_0778	COG0840	transmembrane signaling receptor activity
TTHT_0779	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TTHT_0779	COG0646	methionine synthase
TTHT_0781	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTHT_0784	COG0463	Glycosyl transferase, family 2
TTHT_0789	COG0492	ferredoxin-NADP+ reductase activity
TTHT_0793	COG1301	dicarboxylic acid transport
TTHT_0794	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TTHT_0795	COG0739	heme binding
TTHT_0795	COG0741	lytic transglycosylase activity
TTHT_0795	COG1196	nuclear chromosome segregation
TTHT_0796	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHT_0797	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TTHT_0798	COG0346	lactoylglutathione lyase activity
TTHT_0799	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
TTHT_0801	COG2226	methyltransferase
TTHT_0805	COG1305	Transglutaminase-like
TTHT_0806	COG0632	four-way junction helicase activity
TTHT_0807	COG3104	oligopeptide transport
TTHT_0809	COG1702	phosphate starvation-inducible protein PhoH
TTHT_0810	COG1480	7TM receptor with intracellular HD hydrolase
TTHT_0811	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TTHT_0813	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TTHT_0814	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TTHT_0815	COG1185	polyribonucleotide nucleotidyltransferase activity
TTHT_0816	COG0017	Asparaginyl-tRNA synthetase
TTHT_0817	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_0819	COG1404	Belongs to the peptidase S8 family
TTHT_0821	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
TTHT_0825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TTHT_0826	COG0010	Belongs to the arginase family
TTHT_0827	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
TTHT_0828	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TTHT_0830	COG1127	ABC transporter
TTHT_0831	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TTHT_0833	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTHT_0833	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TTHT_0836	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTHT_0836	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TTHT_0837	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TTHT_0839	COG4604	ABC transporter, ATP-binding protein
TTHT_0841	COG1024	Enoyl-CoA hydratase
TTHT_0841	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_0843	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TTHT_0844	COG0484	heat shock protein binding
TTHT_0845	COG0733	neurotransmitter:sodium symporter activity
TTHT_0848	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TTHT_0848	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TTHT_0849	COG0802	atpase or kinase
TTHT_0850	COG0784	Response regulator, receiver
TTHT_0850	COG2205	protein histidine kinase activity
TTHT_0851	COG0745	RESPONSE REGULATOR receiver
TTHT_0852	COG0280	phosphate acetyltransferase
TTHT_0853	COG0280	phosphate acetyltransferase
TTHT_0854	COG3426	butyrate kinase activity
TTHT_0855	COG0537	adenosine 5'-monophosphoramidase activity
TTHT_0856	COG1160	GTP binding
TTHT_0858	COG1506	peptidase
TTHT_0858	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_0859	COG1960	acyl-CoA dehydrogenase activity
TTHT_0861	COG1773	rubredoxin
TTHT_0861	COG0426	domain, Protein
TTHT_0865	COG0826	peptidase U32
TTHT_0867	COG0425	Belongs to the sulfur carrier protein TusA family
TTHT_0873	COG1250	3-hydroxyacyl-CoA dehydrogenase
TTHT_0874	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
TTHT_0876	COG0488	(ABC) transporter
TTHT_0877	COG1196	nuclear chromosome segregation
TTHT_0879	COG0686	Belongs to the AlaDH PNT family
TTHT_0886	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHT_0887	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TTHT_0888	COG1862	Preprotein translocase
TTHT_0889	COG0343	queuine tRNA-ribosyltransferase activity
TTHT_0890	COG2885	chlorophyll binding
TTHT_0895	COG1722	exodeoxyribonuclease VII activity
TTHT_0897	COG1971	Probably functions as a manganese efflux pump
TTHT_0898	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TTHT_0903	COG0552	protein localization to endoplasmic reticulum
TTHT_0904	COG1355	regulation of microtubule-based process
TTHT_0905	COG1490	D-aminoacyl-tRNA deacylase activity
TTHT_0909	COG0305	Participates in initiation and elongation during chromosome replication
TTHT_0911	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_0917	COG1450	Type ii and iii secretion system protein
TTHT_0920	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_0920	COG1506	peptidase
TTHT_0921	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TTHT_0922	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHT_0922	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHT_0922	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TTHT_0922	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TTHT_0923	COG0793	Belongs to the peptidase S41A family
TTHT_0923	COG4946	Tricorn protease homolog
TTHT_0926	COG0312	modulator of DNA gyrase
TTHT_0927	COG0745	RESPONSE REGULATOR receiver
TTHT_0933	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
TTHT_0934	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TTHT_0935	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
TTHT_0936	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TTHT_0937	COG5002	protein histidine kinase activity
TTHT_0940	COG0148	phosphopyruvate hydratase activity
TTHT_0947	COG0424	maF-like protein
TTHT_0948	COG0776	regulation of translation
TTHT_0949	COG0252	asparaginase activity
TTHT_0950	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TTHT_0953	COG0826	peptidase U32
TTHT_0954	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TTHT_0955	COG0481	GTPase activity
TTHT_0958	COG1136	(ABC) transporter
TTHT_0962	COG1476	TRANSCRIPTIONal
TTHT_0963	COG0355	proton-transporting ATP synthase activity, rotational mechanism
TTHT_0964	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
TTHT_0965	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
TTHT_0967	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
TTHT_0968	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TTHT_0973	COG0745	RESPONSE REGULATOR receiver
TTHT_0976	COG0038	chloride channel
TTHT_0978	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TTHT_0980	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TTHT_0982	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TTHT_0994	COG1509	lysine 2,3-aminomutase activity
TTHT_1001	COG2096	Adenosyltransferase
TTHT_1003	COG2078	PFAM AMMECR1 domain protein
TTHT_1004	COG0469	pyruvate kinase activity
TTHT_1007	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TTHT_1010	COG0513	Belongs to the DEAD box helicase family
TTHT_1012	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TTHT_1014	COG1121	(ABC) transporter
TTHT_1015	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TTHT_1016	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TTHT_1017	COG0789	Transcriptional regulator
TTHT_1018	COG0484	heat shock protein binding
TTHT_1019	COG0443	Heat shock 70 kDa protein
TTHT_1022	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TTHT_1024	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TTHT_1025	COG1082	Xylose isomerase domain protein TIM barrel
TTHT_1026	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTHT_1029	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
TTHT_1030	COG0517	IMP dehydrogenase activity
TTHT_1030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TTHT_1031	COG2877	3-deoxy-8-phosphooctulonate synthase activity
TTHT_1032	COG0504	CTP synthase activity
TTHT_1033	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
TTHT_1038	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TTHT_1041	COG4555	ABC transporter
TTHT_1044	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TTHT_1045	COG2086	electron transfer activity
TTHT_1046	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TTHT_1047	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TTHT_1048	COG0037	tRNA processing
TTHT_1049	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TTHT_1054	COG1366	Belongs to the anti-sigma-factor antagonist family
TTHT_1058	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TTHT_1061	COG0321	lipoyl(octanoyl) transferase activity
TTHT_1061	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
TTHT_1062	COG0617	tRNA 3'-terminal CCA addition
TTHT_1064	COG0183	Belongs to the thiolase family
TTHT_1070	COG1309	transcriptional regulator
TTHT_1077	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TTHT_1079	COG0517	IMP dehydrogenase activity
TTHT_1080	COG0123	including yeast histone deacetylase and acetoin utilization protein
TTHT_1082	COG1914	H( )-stimulated, divalent metal cation uptake system
TTHT_1083	COG0450	alkyl hydroperoxide reductase
TTHT_1087	COG1242	4 iron, 4 sulfur cluster binding
TTHT_1093	COG0517	IMP dehydrogenase activity
TTHT_1093	COG0516	GMP reductase activity
TTHT_1095	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TTHT_1097	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TTHT_1098	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
TTHT_1100	COG0776	regulation of translation
TTHT_1101	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TTHT_1102	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TTHT_1103	COG0037	tRNA processing
TTHT_1106	COG1979	alcohol dehydrogenase
TTHT_1113	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TTHT_1119	COG1392	Phosphate transport regulator
TTHT_1122	COG2954	triphosphatase activity
TTHT_1125	COG3852	Histidine kinase
TTHT_1126	COG2204	response regulator
TTHT_1129	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TTHT_1132	COG1116	anion transmembrane transporter activity
TTHT_1132	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TTHT_1135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TTHT_1141	COG0556	nucleotide-excision repair
TTHT_1143	COG1592	Rubrerythrin
TTHT_1145	COG0242	peptide deformylase activity
TTHT_1146	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TTHT_1147	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TTHT_1148	COG1132	(ABC) transporter
TTHT_1150	COG1561	YicC-like family, N-terminal region
TTHT_1152	COG0471	metal ion transport
TTHT_1158	COG1049	propionate catabolic process, 2-methylcitrate cycle
TTHT_1159	COG0024	Methionine aminopeptidase
TTHT_1160	COG1739	Uncharacterized protein family UPF0029
TTHT_1161	COG1573	uracil-dna glycosylase
TTHT_1162	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TTHT_1164	COG0194	GDP metabolic process
TTHT_1165	COG2052	Domain of unknown function (DUF370)
TTHT_1167	COG0750	zinc metalloprotease
TTHT_1168	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TTHT_1169	COG4589	Belongs to the CDS family
TTHT_1170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TTHT_1171	COG0142	geranyltranstransferase activity
TTHT_1173	COG0708	Exodeoxyribonuclease III
TTHT_1175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTHT_1176	COG0724	RNA recognition motif
TTHT_1177	COG0724	RNA recognition motif
TTHT_1178	COG1047	Peptidyl-prolyl cis-trans
TTHT_1184	COG1598	PFAM Uncharacterised protein family UPF0150
TTHT_1190	COG0356	it plays a direct role in the translocation of protons across the membrane
TTHT_1191	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
TTHT_1192	COG0280	phosphate acetyltransferase
TTHT_1193	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_1193	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_1198	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHT_1199	COG1215	transferase activity, transferring glycosyl groups
TTHT_1200	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TTHT_1209	COG0681	Belongs to the peptidase S26 family
TTHT_1211	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_1212	COG1459	type II secretion system
TTHT_1214	COG2165	general secretion pathway protein
TTHT_1215	COG1100	Small GTP-binding protein
TTHT_1217	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TTHT_1220	COG1193	negative regulation of DNA recombination
TTHT_1221	COG0828	Belongs to the bacterial ribosomal protein bS21 family
TTHT_1225	COG0674	pyruvate-flavodoxin oxidoreductase activity
TTHT_1226	COG1013	pyruvate-flavodoxin oxidoreductase activity
TTHT_1227	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TTHT_1232	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TTHT_1236	COG0542	response to heat
TTHT_1241	COG0352	thiamine-phosphate diphosphorylase activity
TTHT_1243	COG2226	methyltransferase
TTHT_1245	COG0534	Mate efflux family protein
TTHT_1246	COG0483	inositol monophosphate 1-phosphatase activity
TTHT_1248	COG0446	pyridine nucleotide-disulphide oxidoreductase
TTHT_1250	COG1199	ATP-dependent helicase activity
TTHT_1251	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TTHT_1252	COG1007	ATP synthesis coupled electron transport
TTHT_1253	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1254	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTHT_1255	COG0713	ATP synthesis coupled electron transport
TTHT_1257	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1262	COG0649	NAD binding
TTHT_1263	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1264	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1265	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1271	COG0811	peptide transport
TTHT_1272	COG3328	transposase activity
TTHT_1275	COG3008	intermembrane lipid transfer
TTHT_1276	COG2995	paraquat-inducible protein a
TTHT_1278	COG0006	proline dipeptidase activity
TTHT_1279	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TTHT_1283	COG0772	Belongs to the SEDS family
TTHT_1285	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TTHT_1290	COG2001	Belongs to the MraZ family
TTHT_1293	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TTHT_1294	COG1164	Oligoendopeptidase f
TTHT_1295	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TTHT_1296	COG0011	TIGRFAM Protein of
TTHT_1298	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHT_1299	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_1299	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TTHT_1300	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TTHT_1301	COG2022	thiamine diphosphate biosynthetic process
TTHT_1322	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TTHT_1324	COG3328	transposase activity
TTHT_1333	COG0306	phosphate transporter
TTHT_1334	COG1392	Phosphate transport regulator
TTHT_1335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TTHT_1336	COG0052	Belongs to the universal ribosomal protein uS2 family
TTHT_1337	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TTHT_1338	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TTHT_1341	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TTHT_1344	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TTHT_1352	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TTHT_1353	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TTHT_1358	COG0564	pseudouridine synthase activity
TTHT_1361	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
TTHT_1362	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TTHT_1364	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TTHT_1365	COG0571	ribonuclease III activity
TTHT_1367	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHT_1368	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TTHT_1370	COG1674	ftsk spoiiie
TTHT_1373	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
TTHT_1374	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TTHT_1376	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TTHT_1379	COG0835	chemotaxis
TTHT_1379	COG0784	Response regulator, receiver
TTHT_1380	COG5002	protein histidine kinase activity
TTHT_1382	COG5001	Diguanylate cyclase
TTHT_1382	COG4251	negative regulation of phosphorylation
TTHT_1382	COG2203	Gaf domain
TTHT_1382	COG3706	GGDEF domain
TTHT_1390	COG0203	ribosomal protein L17
TTHT_1391	COG0202	RNA polymerase activity
TTHT_1392	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TTHT_1393	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TTHT_1395	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TTHT_1396	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TTHT_1397	COG0563	adenylate kinase activity
TTHT_1398	COG0201	protein transport
TTHT_1400	COG1841	ribosomal large subunit assembly
TTHT_1401	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TTHT_1402	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TTHT_1403	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TTHT_1404	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TTHT_1405	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TTHT_1407	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TTHT_1408	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TTHT_1409	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TTHT_1410	COG0255	Belongs to the universal ribosomal protein uL29 family
TTHT_1411	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TTHT_1412	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TTHT_1413	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TTHT_1414	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TTHT_1415	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TTHT_1416	COG0089	rRNA binding
TTHT_1417	COG0088	Forms part of the polypeptide exit tunnel
TTHT_1418	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TTHT_1419	COG0051	transcription antitermination factor activity, RNA binding
TTHT_1420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTHT_1421	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TTHT_1423	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TTHT_1424	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TTHT_1425	COG0085	RNA polymerase activity
TTHT_1427	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TTHT_1429	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TTHT_1432	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TTHT_1435	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TTHT_1437	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TTHT_1438	COG2205	protein histidine kinase activity
TTHT_1438	COG0784	Response regulator, receiver
TTHT_1439	COG3437	response regulator, receiver
TTHT_1440	COG2183	response to ionizing radiation
TTHT_1440	COG0539	negative regulation of cytoplasmic translation
TTHT_1442	COG3328	transposase activity
TTHT_1443	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
TTHT_1444	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TTHT_1445	COG0295	cytidine deaminase activity
TTHT_1447	COG1181	Belongs to the D-alanine--D-alanine ligase family
TTHT_1448	COG0357	Ribosomal RNA small subunit methyltransferase G
TTHT_1449	COG4191	Histidine kinase
TTHT_1449	COG0784	Response regulator, receiver
TTHT_1450	COG2204	response regulator
TTHT_1451	COG0745	RESPONSE REGULATOR receiver
TTHT_1454	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TTHT_1456	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
TTHT_1459	COG3328	transposase activity
TTHT_1463	COG1450	Type ii and iii secretion system protein
TTHT_1473	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_1476	COG0126	phosphoglycerate kinase activity
TTHT_1476	COG0149	triose-phosphate isomerase activity
TTHT_1477	COG0126	phosphoglycerate kinase activity
TTHT_1477	COG0149	triose-phosphate isomerase activity
TTHT_1479	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TTHT_1488	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TTHT_1491	COG1040	competence protein
TTHT_1496	COG0489	protein tyrosine kinase activity
TTHT_1498	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TTHT_1499	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TTHT_1500	COG0390	transport system, permease component
TTHT_1501	COG2226	methyltransferase
TTHT_1504	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
TTHT_1508	COG1286	toxin biosynthetic process
TTHT_1510	COG3604	Transcriptional regulator
TTHT_1512	COG0470	DNA polymerase III
TTHT_1514	COG1716	ATPase activity
TTHT_1515	COG0328	RNA-DNA hybrid ribonuclease activity
TTHT_1516	COG0358	DNA primase activity
TTHT_1521	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TTHT_1522	COG2003	Belongs to the UPF0758 family
TTHT_1523	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TTHT_1525	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TTHT_1525	COG2199	diguanylate cyclase activity
TTHT_1527	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TTHT_1529	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TTHT_1530	COG1496	oxidoreductase activity
TTHT_1532	COG5002	protein histidine kinase activity
TTHT_1533	COG0745	RESPONSE REGULATOR receiver
TTHT_1534	COG3005	denitrification pathway
TTHT_1542	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHT_1544	COG3033	Beta-eliminating lyase
TTHT_1545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TTHT_1556	COG2204	response regulator
TTHT_1557	COG3852	Histidine kinase
TTHT_1561	COG0277	FAD linked oxidase domain protein
TTHT_1563	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTHT_1563	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TTHT_1568	COG4232	protein-disulfide reductase activity
TTHT_1570	COG0247	lactate metabolic process
TTHT_1571	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TTHT_1571	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TTHT_1578	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHT_1581	COG0612	Peptidase, M16
TTHT_1585	COG0237	dephospho-CoA kinase activity
TTHT_1586	COG1703	isobutyryl-CoA mutase activity
TTHT_1587	COG1960	acyl-CoA dehydrogenase activity
TTHT_1588	COG0793	Belongs to the peptidase S41A family
TTHT_1593	COG0084	hydrolase, TatD family'
TTHT_1594	COG1968	undecaprenyl-diphosphatase activity
TTHT_1596	COG0463	Glycosyl transferase, family 2
TTHT_1596	COG1216	Glycosyl transferase, family 2
TTHT_1597	COG0519	Catalyzes the synthesis of GMP from XMP
TTHT_1597	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TTHT_1598	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTHT_1600	COG1077	Cell shape determining protein MreB Mrl
TTHT_1604	COG1045	serine acetyltransferase
TTHT_1605	COG1100	Small GTP-binding protein
TTHT_1609	COG0495	leucyl-tRNA aminoacylation
TTHT_1613	COG2131	deaminase
TTHT_1614	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TTHT_1615	COG0698	ribose 5-phosphate isomerase
TTHT_1616	COG2235	arginine
TTHT_1617	COG5297	Belongs to the glycosyl hydrolase family 6
TTHT_1617	COG4733	cellulase activity
TTHT_1618	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
TTHT_1619	COG0084	hydrolase, TatD family'
TTHT_1620	COG1166	arginine decarboxylase activity
TTHT_1621	COG0778	Nitroreductase
TTHT_1623	COG0697	spore germination
TTHT_1629	COG2271	Major facilitator Superfamily
TTHT_1632	COG3706	GGDEF domain
TTHT_1633	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TTHT_1635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TTHT_1636	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TTHT_1640	COG0535	radical SAM domain protein
TTHT_1652	COG0124	histidyl-tRNA synthetase
TTHT_1653	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TTHT_1656	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
TTHT_1657	COG4771	TonB-dependent receptor
TTHT_1660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TTHT_1661	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TTHT_1662	COG0077	Prephenate dehydratase
TTHT_1662	COG1605	Chorismate mutase
TTHT_1664	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHT_1666	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TTHT_1668	COG0210	DNA helicase
TTHT_1671	COG1100	Small GTP-binding protein
TTHT_1674	COG1595	DNA-templated transcription, initiation
TTHT_1680	COG0511	ligase activity, forming carbon-carbon bonds
TTHT_1680	COG5016	pyruvate
TTHT_1690	COG1459	type II secretion system
TTHT_1693	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TTHT_1694	COG1494	fructose-1,6-bisphosphatase
TTHT_1695	COG1960	acyl-CoA dehydrogenase activity
TTHT_1696	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TTHT_1697	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TTHT_1698	COG2815	serine threonine protein kinase
TTHT_1698	COG0515	serine threonine protein kinase
TTHT_1700	COG0736	holo-[acyl-carrier-protein] synthase activity
TTHT_1701	COG0359	binds to the 23S rRNA
TTHT_1702	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
TTHT_1703	COG1757	Na H antiporter
TTHT_1704	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TTHT_1709	COG0233	cytoplasmic translational termination
TTHT_1710	COG0528	UMP kinase activity
TTHT_1711	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TTHT_1714	COG0351	phosphomethylpyrimidine kinase
TTHT_1714	COG0352	thiamine-phosphate diphosphorylase activity
TTHT_1715	COG0512	Glutamine amidotransferase of anthranilate synthase
TTHT_1715	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TTHT_1718	COG1295	ribonuclease BN
TTHT_1720	COG5000	phosphorelay sensor kinase activity
TTHT_1724	COG2848	UPF0210 protein
TTHT_1725	COG3830	Belongs to the UPF0237 family
TTHT_1728	COG1960	acyl-CoA dehydrogenase activity
TTHT_1730	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TTHT_1731	COG0326	Molecular chaperone. Has ATPase activity
TTHT_1739	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TTHT_1740	COG3118	belongs to the thioredoxin family
TTHT_1742	COG1222	aaa ATPase
TTHT_1747	COG1007	ATP synthesis coupled electron transport
TTHT_1750	COG0713	ATP synthesis coupled electron transport
TTHT_1751	COG0839	Belongs to the complex I subunit 6 family
TTHT_1752	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1753	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TTHT_1755	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1756	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1757	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1760	COG3328	transposase activity
TTHT_1769	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TTHT_1770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TTHT_1772	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TTHT_1773	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TTHT_1774	COG1187	pseudouridine synthase activity
TTHT_1776	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TTHT_1777	COG0180	Tryptophanyl-tRNA synthetase
TTHT_1778	COG1994	Peptidase M50
TTHT_1779	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TTHT_1780	COG2165	general secretion pathway protein
TTHT_1781	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TTHT_1783	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TTHT_1784	COG1530	ribonuclease E activity
TTHT_1785	COG1752	Esterase of the alpha-beta hydrolase superfamily
TTHT_1790	COG4946	Tricorn protease homolog
TTHT_1790	COG0793	Belongs to the peptidase S41A family
TTHT_1791	COG1373	ATPase (AAA superfamily
TTHT_1793	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TTHT_1796	COG2239	Acts as a magnesium transporter
TTHT_1798	COG0436	Aminotransferase
TTHT_1801	COG1597	lipid kinase activity
TTHT_1804	COG1376	ErfK ybiS ycfS ynhG family protein
TTHT_1806	COG1012	belongs to the aldehyde dehydrogenase family
TTHT_1810	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TTHT_1820	COG0673	inositol 2-dehydrogenase activity
TTHT_1821	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_1821	COG1506	peptidase
TTHT_1825	COG0463	Glycosyl transferase, family 2
TTHT_1827	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TTHT_1828	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TTHT_1830	COG0450	alkyl hydroperoxide reductase
TTHT_1831	COG2033	superoxide reductase activity
TTHT_1832	COG5002	protein histidine kinase activity
TTHT_1833	COG0251	oxidation-reduction process
TTHT_1834	COG2226	methyltransferase
TTHT_1837	COG1993	acr, cog1993
TTHT_1838	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TTHT_1839	COG2954	triphosphatase activity
TTHT_1840	COG1205	dead DEAH box helicase
TTHT_1840	COG1111	helicase
TTHT_1841	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TTHT_1842	COG1053	succinate dehydrogenase
TTHT_1843	COG2009	succinate dehydrogenase
TTHT_1844	COG0039	L-malate dehydrogenase activity
TTHT_1845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TTHT_1848	COG0557	exoribonuclease II activity
TTHT_1849	COG1774	PSP1 C-terminal conserved region
TTHT_1851	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TTHT_1855	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TTHT_1856	COG1489	DNA binding
TTHT_1857	COG0181	hydroxymethylbilane synthase activity
TTHT_1859	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TTHT_1863	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TTHT_1864	COG0564	pseudouridine synthase activity
TTHT_1865	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TTHT_1867	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TTHT_1873	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TTHT_1874	COG1449	Belongs to the glycosyl hydrolase 57 family
TTHT_1876	COG2020	methyltransferase activity
TTHT_1877	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TTHT_1878	COG4974	Belongs to the 'phage' integrase family
TTHT_1882	COG0101	tRNA pseudouridine synthase activity
TTHT_1885	COG0038	chloride channel
TTHT_1887	COG2204	response regulator
TTHT_1889	COG0668	transmembrane transport
TTHT_1892	COG0730	response to heat
TTHT_1895	COG0640	Transcriptional regulator
TTHT_1896	COG0798	PFAM Bile acid sodium symporter
TTHT_1897	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TTHT_1905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TTHT_1906	COG0300	oxidoreductase activity
TTHT_1907	COG0525	valine-tRNA ligase activity
TTHT_1909	COG1966	Carbon starvation protein
TTHT_1910	COG0668	transmembrane transport
TTHT_1911	COG1022	Amp-dependent synthetase and ligase
TTHT_1912	COG1309	transcriptional regulator
TTHT_1913	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TTHT_1914	COG0569	domain protein
TTHT_1923	COG5002	protein histidine kinase activity
TTHT_1926	COG0649	NAD binding
TTHT_1927	COG0649	NAD binding
TTHT_1928	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TTHT_1931	COG0651	ATP synthesis coupled electron transport
TTHT_1932	COG0651	ATP synthesis coupled electron transport
TTHT_1933	COG1006	Multisubunit Na H antiporter MnhC subunit
TTHT_1934	COG2111	Na H antiporter
TTHT_1934	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TTHT_1936	COG1320	monovalent cation:proton antiporter activity
TTHT_1938	COG1863	multisubunit Na H antiporter MnhE subunit
TTHT_1940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHT_1946	COG1215	transferase activity, transferring glycosyl groups
TTHT_1948	COG0562	UDP-galactopyranose mutase
TTHT_1950	COG0438	transferase activity, transferring glycosyl groups
TTHT_1955	COG0529	Catalyzes the synthesis of activated sulfate
TTHT_1955	COG2895	sulfate adenylyltransferase (ATP) activity
TTHT_1956	COG2895	sulfate adenylyltransferase (ATP) activity
TTHT_1959	COG0175	sulfate reduction
TTHT_1961	COG0297	glycogen (starch) synthase activity
TTHT_1969	COG2205	protein histidine kinase activity
TTHT_1970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TTHT_1971	COG0601	transmembrane transport
TTHT_1972	COG2204	response regulator
TTHT_1975	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
TTHT_1975	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
TTHT_1976	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TTHT_1978	COG1100	Small GTP-binding protein
TTHT_1981	COG1028	Short-chain dehydrogenase reductase Sdr
TTHT_1982	COG0302	gtp cyclohydrolase
TTHT_1991	COG2161	toxin-antitoxin pair type II binding
TTHT_1993	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TTHT_2017	COG0752	glycyl-tRNA synthetase alpha subunit
TTHT_2018	COG0751	glycine-tRNA ligase activity
TTHT_2020	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TTHT_2027	COG1131	(ABC) transporter
TTHT_2036	COG0285	dihydrofolate synthase activity
TTHT_2037	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TTHT_2039	COG1475	DNA binding
TTHT_2040	COG1192	Involved in chromosome partitioning
TTHT_2041	COG0445	tRNA wobble uridine modification
TTHT_2042	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TTHT_2044	COG0706	membrane insertase activity
TTHT_2046	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TTHT_2047	COG0594	ribonuclease P activity
TTHT_2048	COG0230	Belongs to the bacterial ribosomal protein bL34 family
TTHT_2049	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TTHT_2049	COG0473	3-isopropylmalate dehydrogenase activity
TTHT_2054	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
TTHT_2057	COG0187	DNA topoisomerase II activity
TTHT_2058	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TTHT_2059	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TTHT_2060	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TTHT_2061	COG3706	GGDEF domain
TTHT_2064	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TTHT_2065	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TTHT_2066	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TTHT_2068	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TTHT_2070	COG1598	PFAM Uncharacterised protein family UPF0150
TTHT_2077	COG0301	tRNA thio-modification
TTHT_2079	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TTHT_2080	COG0066	3-isopropylmalate dehydratase activity
TTHT_2081	COG1381	Involved in DNA repair and RecF pathway recombination
TTHT_2087	COG0489	protein tyrosine kinase activity
TTHT_2088	COG1342	Belongs to the UPF0251 family
TTHT_2089	COG3426	butyrate kinase activity
TTHT_2090	COG0280	phosphate acetyltransferase
TTHT_2093	COG4953	penicillin-binding protein 1C
TTHT_2094	COG2373	Large extracellular alpha-helical protein
TTHT_2097	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
TTHT_2098	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TTHT_2098	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TTHT_2099	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
TTHT_2099	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
TTHT_2103	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TTHT_2104	COG0281	malic enzyme
TTHT_2105	COG0157	Belongs to the NadC ModD family
TTHT_2112	COG1238	metal cluster binding
TTHT_2113	COG1254	Belongs to the acylphosphatase family
TTHT_2122	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TTHT_2123	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TTHT_2128	COG0731	radical SAM domain protein
TTHT_2128	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TTHT_2133	COG0493	'glutamate synthase
TTHT_2135	COG0823	Involved in the tonB-independent uptake of proteins
TTHT_2139	COG0811	peptide transport
TTHT_2140	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TTHT_2143	COG0497	DNA recombination
TTHT_2144	COG3852	Histidine kinase
TTHT_2146	COG3409	Peptidoglycan-binding domain 1 protein
TTHT_2146	COG0793	Belongs to the peptidase S41A family
TTHT_2153	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TTHT_2156	COG0728	peptidoglycan biosynthetic process
TTHT_2157	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TTHT_2158	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TTHT_2159	COG0779	Required for maturation of 30S ribosomal subunits
TTHT_2160	COG0195	Participates in both transcription termination and antitermination
TTHT_2163	COG1550	Protein conserved in bacteria
TTHT_2168	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TTHT_2169	COG1335	isochorismatase
TTHT_2170	COG0737	Belongs to the 5'-nucleotidase family
TTHT_2171	COG1333	cytochrome c biogenesis protein
TTHT_2175	COG1297	OPT oligopeptide transporter protein
TTHT_2177	COG1024	Enoyl-CoA hydratase
TTHT_2179	COG1090	epimerase
TTHT_2180	COG4974	Belongs to the 'phage' integrase family
TTHT_2181	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TTHT_2181	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
TTHT_2181	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TTHT_2184	COG0475	glutathione-regulated potassium exporter activity
TTHT_2189	COG2986	histidine ammonia-lyase
TTHT_2190	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
TTHT_2191	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
TTHT_2192	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TTHT_2199	COG1960	acyl-CoA dehydrogenase activity
TTHT_2200	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TTHT_2201	COG4221	oxidoreductase activity
TTHT_2202	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
TTHT_2204	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TTHT_2208	COG0612	Peptidase, M16
TTHT_2209	COG0791	NLP P60 protein
TTHT_2209	COG1388	LysM domain
TTHT_2209	COG3103	Sh3 type 3 domain protein
TTHT_2210	COG0822	iron-sulfur transferase activity
TTHT_2211	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TTHT_2212	COG0719	Fe-S assembly protein
TTHT_2213	COG0719	Fe-S assembly protein
TTHT_2215	COG1959	2 iron, 2 sulfur cluster binding
TTHT_2216	COG0506	proline dehydrogenase activity
TTHT_2217	COG5000	phosphorelay sensor kinase activity
TTHT_2220	COG0745	RESPONSE REGULATOR receiver
TTHT_2221	COG1388	LysM domain
TTHT_2221	COG0791	NLP P60 protein
TTHT_2222	COG0606	chelatase, subunit chli
TTHT_2223	COG0095	Lipoate-protein ligase
TTHT_2224	COG0138	bifunctional purine biosynthesis protein purh
TTHT_2227	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TTHT_2231	COG1115	amino acid carrier protein
TTHT_2232	COG3706	GGDEF domain
TTHT_2233	COG0720	synthase
TTHT_2234	COG0602	queuosine metabolic process
TTHT_2237	COG3959	Transketolase, thiamine diphosphate binding domain
TTHT_2238	COG0572	uridine kinase
TTHT_2239	COG3958	Transketolase
TTHT_2240	COG2884	Cell division ATP-binding protein ftsE
TTHT_2242	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TTHT_2243	COG1830	Aldolase