locus-tag	class	description
Theam_0001	ENOG4105CRQ	synthase (Component I)
Theam_0002	ENOG4105CDU	Replicative dna helicase
Theam_0004	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Theam_0005	ENOG4107RA4	Glycosyl transferase (Group 1
Theam_0006	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Theam_0007	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Theam_0008	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Theam_0009	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Theam_0010	ENOG4105CTB	Polyprenyl synthetase
Theam_0011	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Theam_0038	ENOG41080YA	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
Theam_0068	ENOG4105HF0	Membrane
Theam_0071	ENOG4108V9Q	carbonic anhydrase
Theam_0073	ENOG4107RHB	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates (By similarity)
Theam_0075	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Theam_0076	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Theam_0077	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
Theam_0080	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Theam_0081	ENOG4105EAH	synthase
Theam_0085	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Theam_0087	ENOG4105WCA	Ferredoxin
Theam_0088	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Theam_0089	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Theam_0090	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Theam_0091	ENOG4105CE9	30S ribosomal protein S2
Theam_0094	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Theam_0096	ENOG4105HF0	Membrane
Theam_0098	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Theam_0100	ENOG4105ZH5	Protein of unknown function (DUF964)
Theam_0104	ENOG4105CNW	domain protein
Theam_0107	ENOG4108Z4T	Peptidase M50
Theam_0108	ENOG4105NBF	ammecr1 domain protein
Theam_0109	ENOG4105WMR	Protein CrcB homolog
Theam_0111	ENOG4105HHA	aminodeoxychorismate lyase
Theam_0112	ENOG4108VTU	Cdp-alcohol phosphatidyltransferase
Theam_0113	ENOG4105CXV	gliding motility protein
Theam_0119	ENOG4105N5T	Radical SAM Protein
Theam_0123	ENOG4105C03	ribonuclease
Theam_0127	ENOG4105C3F	Signal peptidase i
Theam_0131	ENOG4108VIA	integral membrane protein
Theam_0132	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Theam_0133	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Theam_0134	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Theam_0135	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Theam_0136	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Theam_0137	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Theam_0139	ENOG4105BZU	Histidine kinase
Theam_0140	ENOG4105E2X	shikimate dehydrogenase
Theam_0141	ENOG4107PU6	Membrane
Theam_0142	ENOG4105K46	50S ribosomal protein l27
Theam_0143	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Theam_0145	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Theam_0146	ENOG4105CH7	arginosuccinase
Theam_0147	ENOG4108HHA	Transketolase
Theam_0149	ENOG4105CN1	protease
Theam_0150	ENOG410626R	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)
Theam_0151	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Theam_0153	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Theam_0155	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
Theam_0157	ENOG4105C8Q	Methyl-accepting chemotaxis
Theam_0158	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Theam_0159	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Theam_0160	ENOG4105CB5	ATP-dependent DNA helicase recG
Theam_0163	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Theam_0164	ENOG4105CMQ	Chloride channel
Theam_0165	ENOG4105C8Q	Methyl-accepting chemotaxis
Theam_0166	ENOG4105BZU	Histidine kinase
Theam_0168	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Theam_0170	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Theam_0171	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Theam_0176	ENOG41083W3	Multi-copper polyphenol oxidoreductase laccase
Theam_0177	ENOG4105C79	DNA protecting protein DprA
Theam_0179	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Theam_0180	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Theam_0182	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Theam_0184	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Theam_0186	ENOG4105C1X	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity)
Theam_0189	ENOG4106EG9	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)
Theam_0190	ENOG4105D6E	homoserine dehydrogenase
Theam_0191	ENOG4105CHM	Aminotransferase
Theam_0193	ENOG4105EHG	Permease protein
Theam_0194	ENOG4108F1U	ABC transporter
Theam_0196	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
Theam_0201	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Theam_0205	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Theam_0206	ENOG4105BZA	Phosphoglycerate kinase
Theam_0210	ENOG41068KG	domain protein
Theam_0211	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
Theam_0212	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Theam_0213	ENOG4105DCI	Phosphohydrolase
Theam_0214	ENOG4105G5W	regulator Fur family
Theam_0215	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Theam_0218	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Theam_0220	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Theam_0221	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Theam_0222	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Theam_0227	ENOG4105C5R	Aminotransferase
Theam_0228	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Theam_0229	ENOG4105EW6	flavin reductase domain protein, FMN-binding
Theam_0230	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Theam_0231	ENOG4105EGD	dinuclear metal center protein, YbgI family
Theam_0233	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Theam_0234	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Theam_0235	ENOG4105DR4	Methyltransferase
Theam_0236	ENOG4107QZT	geranylgeranyl reductase
Theam_0237	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Theam_0239	ENOG4105DDQ	anthranilate synthase
Theam_0240	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Theam_0241	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
Theam_0243	ENOG4108RBV	CRISPR-associated protein, Csx3 family
Theam_0244	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Theam_0245	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Theam_0246	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Theam_0247	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Theam_0250	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Theam_0252	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Theam_0253	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Theam_0254	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Theam_0255	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Theam_0256	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Theam_0257	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Theam_0258	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Theam_0259	ENOG41082UH	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Theam_0260	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Theam_0261	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Theam_0262	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Theam_0263	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Theam_0264	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Theam_0265	ENOG4107FF9	50s ribosomal protein l29
Theam_0266	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Theam_0267	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Theam_0268	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Theam_0269	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Theam_0270	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Theam_0271	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Theam_0272	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Theam_0273	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Theam_0274	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Theam_0275	ENOG4105VPB	50S ribosomal protein L30
Theam_0276	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Theam_0277	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Theam_0278	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Theam_0280	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Theam_0281	ENOG41067V7	50S ribosomal protein L36
Theam_0282	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Theam_0283	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Theam_0284	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Theam_0285	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Theam_0286	ENOG4108ZT0	50S ribosomal protein l17
Theam_0288	ENOG4107QMS	site-determining protein
Theam_0289	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Theam_0291	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Theam_0292	ENOG4108JVH	Protein of unknown function DUF43
Theam_0295	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
Theam_0297	ENOG4107ZTA	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Theam_0298	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Theam_0299	ENOG41083NI	Binds together with S18 to 16S ribosomal RNA (By similarity)
Theam_0301	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Theam_0303	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Theam_0305	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Theam_0306	ENOG4105KME	endoribonuclease L-psp
Theam_0307	ENOG4107YCR	Transcriptional regulator, ARSR family
Theam_0308	ENOG4108IDZ	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Theam_0310	ENOG4108JA2	transcriptioN-repair coupling factor
Theam_0314	ENOG4107QMV	Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity)
Theam_0315	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Theam_0317	ENOG4108R88	cytochrome C
Theam_0319	ENOG4105HEE	Binding Domain protein
Theam_0321	ENOG4105K4W	Could be involved in septation (By similarity)
Theam_0324	ENOG4105KG3	cytidine deaminase
Theam_0325	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Theam_0327	ENOG4105CBC	glutamate synthase
Theam_0328	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Theam_0329	ENOG4107QX8	SPFH domain, Band 7 family protein
Theam_0332	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Theam_0333	ENOG4105DB7	PHP domain protein
Theam_0336	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Theam_0337	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Theam_0338	ENOG4105DC7	peptidase M24
Theam_0341	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
Theam_0345	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Theam_0347	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Theam_0348	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Theam_0349	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Theam_0353	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Theam_0355	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Theam_0356	ENOG4105C1A	potassium transporter peripheral membrane
Theam_0357	ENOG4105CRE	cytochrome C
Theam_0358	ENOG4105EBH	Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity)
Theam_0359	ENOG4107SYB	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Theam_0360	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Theam_0365	ENOG4105D1H	recombination factor protein RarA
Theam_0366	ENOG4105C8Q	Methyl-accepting chemotaxis
Theam_0369	ENOG4105C34	Pseudouridine synthase
Theam_0371	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Theam_0373	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Theam_0374	ENOG4105CFH	Aspartokinase
Theam_0375	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Theam_0377	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Theam_0378	ENOG4108UJD	30S ribosomal protein S9
Theam_0379	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Theam_0381	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Theam_0382	ENOG4108Z0R	Transferase
Theam_0386	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Theam_0389	ENOG4105CSZ	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)
Theam_0390	ENOG41084ZW	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Theam_0392	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Theam_0393	ENOG4105CHR	reductase
Theam_0396	ENOG4105BZU	Histidine kinase
Theam_0399	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Theam_0404	ENOG4105DZ0	fad dependent oxidoreductase
Theam_0406	ENOG4105DKP	glycosyl transferase, family 9
Theam_0410	ENOG4105WH1	Two component transcriptional regulator luxr family
Theam_0411	ENOG4107QMP	dna polymerase iii subunits gamma and tau
Theam_0412	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Theam_0413	ENOG4107S91	Sodium hydrogen exchanger
Theam_0416	ENOG4105EVD	ribosomal RNA large subunit methyltransferase N
Theam_0417	ENOG4105MA4	psp1 domain protein
Theam_0423	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
Theam_0426	ENOG4105HEE	Binding Domain protein
Theam_0428	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Theam_0429	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Theam_0431	ENOG4105C6T	cysteine synthase
Theam_0433	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Theam_0434	ENOG41082DI	50s ribosomal protein l31
Theam_0435	ENOG4105DQR	SNARE associated Golgi
Theam_0436	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Theam_0437	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Theam_0438	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Theam_0439	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Theam_0440	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Theam_0441	ENOG41061GT	Aldolase
Theam_0444	ENOG4105C1A	potassium transporter peripheral membrane
Theam_0448	ENOG4108R6K	riboflavin synthase, subunit alpha
Theam_0450	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Theam_0452	ENOG4105WCJ	ec 1.1.1.193
Theam_0454	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Theam_0455	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Theam_0457	ENOG4105D7W	serine acetyltransferase
Theam_0459	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Theam_0460	ENOG4108ZP8	Acetolactate synthase small subunit
Theam_0461	ENOG4105C7K	acetolactate synthase
Theam_0462	ENOG4105CRQ	synthase (Component I)
Theam_0464	ENOG4105C2X	Arabinose 5-phosphate isomerase
Theam_0466	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Theam_0470	ENOG4105VG0	50S ribosomal protein l34
Theam_0471	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Theam_0472	ENOG41084DJ	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Theam_0473	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Theam_0474	ENOG4108JU6	CBS domain protein
Theam_0475	ENOG4105C37	(CBS) domain
Theam_0476	ENOG41081XG	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0478	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0480	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0481	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Theam_0482	ENOG4105D65	subunit l
Theam_0485	ENOG4105E3S	small subunit
Theam_0486	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Theam_0488	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Theam_0491	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
Theam_0492	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Theam_0493	ENOG4105CAS	nag kinase
Theam_0494	ENOG4105C4M	(Ubiquinol oxidase) subunit I
Theam_0495	ENOG4105CFY	cytochrome d ubiquinol oxidase, subunit ii
Theam_0500	ENOG4105KW8	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)
Theam_0501	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Theam_0502	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Theam_0503	ENOG4105VM1	flagellar
Theam_0506	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Theam_0507	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Theam_0508	ENOG4105CRE	cytochrome C
Theam_0509	ENOG4105FF2	Type I DHQase
Theam_0510	ENOG4105KJJ	Uncharacterized ACR, COG1993
Theam_0511	ENOG4107QHF	type ii secretion system protein e
Theam_0513	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Theam_0517	ENOG4105CFP	Peptidase U32
Theam_0519	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Theam_0520	ENOG4105D52	delta-aminolevulinic acid dehydratase
Theam_0522	ENOG4105CNW	domain protein
Theam_0523	ENOG41085TX	30S ribosomal protein S21
Theam_0524	ENOG4105KTH	gatB Yqey
Theam_0525	ENOG4105C98	muts2 protein
Theam_0526	ENOG4105C8Y	Acetylornithine aminotransferase
Theam_0529	ENOG4107RY6	amino acid
Theam_0530	ENOG41084M5	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
Theam_0534	ENOG4105C01	Dihydroxy-acid dehydratase
Theam_0536	ENOG41067MN	Spore coat polysaccharide biosynthesis protein spsD
Theam_0537	ENOG41072GX	Peptidase M22 Glycoprotease
Theam_0540	ENOG4105CQR	helicase
Theam_0543	ENOG4105CKF	membrane protein involved in aromatic hydrocarbon degradation
Theam_0548	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Theam_0549	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Theam_0557	ENOG4107ZYR	domain protein
Theam_0558	ENOG4105CHM	Aminotransferase
Theam_0559	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Theam_0561	ENOG4105D0U	Arsenite-activated ATPase (ArsA)
Theam_0564	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Theam_0565	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Theam_0568	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Theam_0569	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Theam_0570	ENOG4105CUT	histidyl-tRNA synthetase
Theam_0573	ENOG4105BZU	Histidine kinase
Theam_0576	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
Theam_0577	ENOG4108I19	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)
Theam_0580	ENOG4105DBZ	Dtdp-4-dehydrorhamnose reductase
Theam_0582	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Theam_0586	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Theam_0587	ENOG4105K8N	protein family UPF0079, ATPase
Theam_0588	ENOG4105M8F	Biopolymer transport protein exbD tolR
Theam_0589	ENOG4105CHM	Aminotransferase
Theam_0591	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Theam_0592	ENOG41082E4	Binds directly to 16S ribosomal RNA (By similarity)
Theam_0593	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Theam_0595	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Theam_0597	ENOG4107BJW	polysaccharide deacetylase
Theam_0598	ENOG4105BZ1	(ABC) transporter
Theam_0600	ENOG4108KMV	Glycosyl transferase (Group 1
Theam_0602	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Theam_0603	ENOG4106DSS	Tartrate dehydratase subunit alpha
Theam_0604	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Theam_0605	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Theam_0607	ENOG4105BZU	Histidine kinase
Theam_0608	ENOG4105WPN	DNA integration recombination invertion protein
Theam_0609	ENOG4105C3R	Methionine synthase
Theam_0610	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
Theam_0611	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Theam_0612	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Theam_0613	ENOG4108Z03	MAF-like protein
Theam_0615	ENOG4107QQR	Sporulation
Theam_0616	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Theam_0617	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Theam_0618	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Theam_0619	ENOG4108RQ5	Beta-lactamase domain-containing protein
Theam_0620	ENOG4105Q33	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency
Theam_0621	ENOG4107YI3	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Theam_0623	ENOG4106C8N	
Theam_0628	ENOG4108YZA	Nitrogen regulatory protein pii
Theam_0629	ENOG4105C5F	glutamine synthetase
Theam_0631	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Theam_0638	ENOG4105EV6	Pfam:DUF178
Theam_0639	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Theam_0640	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Theam_0641	ENOG4105W5Q	DNA repair protein (RadC
Theam_0642	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Theam_0645	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Theam_0646	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Theam_0648	ENOG4106KXD	ATP-dependent carboxylate-amine ligase (By similarity)
Theam_0651	ENOG4105E1P	Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity)
Theam_0655	ENOG4105CP7	Triose-phosphate isomerase
Theam_0656	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Theam_0657	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Theam_0661	ENOG4105C9M	aspartyl-trna synthetase
Theam_0663	ENOG4108RNI	3'(2')5'-bisphosphate nucleotidase
Theam_0665	ENOG4108I67	Catalyzes the synthesis of activated sulfate (By similarity)
Theam_0666	ENOG4107RIQ	Sulfate adenylate transferase
Theam_0669	ENOG4107VDP	teichoic acid biosynthesis
Theam_0671	ENOG4108TJN	glycosyl transferase group 1
Theam_0674	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Theam_0675	ENOG4105D3Q	Sugar transferase
Theam_0676	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Theam_0677	ENOG4108V7X	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Theam_0678	ENOG4105CHM	Aminotransferase
Theam_0681	ENOG4107Z3H	Transcriptional regulator, TetR family
Theam_0682	ENOG4105CIZ	coA-substrate-specific enzyme activase
Theam_0683	ENOG4105BZU	Histidine kinase
Theam_0684	ENOG4105D22	carbon starvation protein
Theam_0688	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Theam_0689	ENOG4105FAV	ABC, transporter
Theam_0691	ENOG4107YFT	Nadph-dependent fmn reductase
Theam_0692	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Theam_0695	ENOG4106VK0	
Theam_0697	ENOG4106Z6D	Molecular chaperone capable of stabilizing a range of proteins (By similarity)
Theam_0698	ENOG4105JVV	
Theam_0699	ENOG4108RMN	UPF0128 protein
Theam_0701	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
Theam_0704	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Theam_0707	ENOG4105MJ2	Competence protein
Theam_0708	ENOG4108JQ7	(ABC) transporter
Theam_0710	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
Theam_0713	ENOG4105K6T	rare lipoprotein A
Theam_0714	ENOG4108IYU	L-aspartate oxidase
Theam_0715	ENOG4107R4C	succinyl-diaminopimelate desuccinylase
Theam_0717	ENOG4105D4A	Cell wall formation (By similarity)
Theam_0718	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Theam_0719	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Theam_0720	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Theam_0721	ENOG4105VR9	phosphoribosylformylglycinamidine synthase
Theam_0723	ENOG4107TEJ	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Theam_0724	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Theam_0725	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Theam_0726	ENOG4105EI2	Pseudouridine synthase
Theam_0729	ENOG4107X35	defense response to bacterium
Theam_0730	ENOG4107GFK	fumarate
Theam_0731	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Theam_0732	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0733	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Theam_0734	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0735	ENOG4105GKE	subunit e
Theam_0738	ENOG4105IJJ	transcriptional regulator, crp fnr family
Theam_0739	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Theam_0740	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0741	ENOG4107UFS	subunit j
Theam_0742	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0743	ENOG4105D65	subunit l
Theam_0744	ENOG4105C8S	subunit m
Theam_0745	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_0746	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
Theam_0747	ENOG4105D05	Receptor
Theam_0749	ENOG4105BZU	Histidine kinase
Theam_0751	ENOG4108WZM	domain protein
Theam_0755	ENOG41089BK	Glutamine amido-transferase
Theam_0756	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Theam_0757	ENOG4105C4K	Nad synthetase
Theam_0761	ENOG41080IJ	Diacylglycerol kinase
Theam_0762	ENOG4105CTJ	Metal Dependent Phosphohydrolase
Theam_0763	ENOG4105C9A	Phoh family
Theam_0764	ENOG4105EGS	Mechanosensitive ion channel
Theam_0765	ENOG4105C5H	ABC transporter
Theam_0767	ENOG4105C8J	)-transporter
Theam_0768	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Theam_0769	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Theam_0770	ENOG4105SFS	phosphoesterase RecJ domain protein
Theam_0771	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
Theam_0772	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Theam_0773	ENOG41087GE	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Theam_0785	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Theam_0787	ENOG4108IJ6	ABC transporter
Theam_0788	ENOG4105E0C	molybdate abc transporter
Theam_0789	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Theam_0795	ENOG4105KZJ	alginate biosynthesis protein Alg8
Theam_0797	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Theam_0798	ENOG4108VQJ	O-methyltransferase
Theam_0800	ENOG4105C2M	dna polymerase I
Theam_0801	ENOG4105DFU	Cell wall formation (By similarity)
Theam_0802	ENOG4108IAJ	Nad-dependent epimerase dehydratase
Theam_0807	ENOG4105CG5	Glycosyl transferase (Group 1
Theam_0813	ENOG4105ERH	Fumarylacetoacetate hydrolase
Theam_0815	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Theam_0816	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Theam_0819	ENOG4108JIS	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Theam_0820	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Theam_0822	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Theam_0823	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Theam_0824	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Theam_0825	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Theam_0827	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Theam_0828	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Theam_0829	ENOG4105E4C	Lytic transglycosylase catalytic
Theam_0831	ENOG4108W8G	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity)
Theam_0832	ENOG4105EGS	Mechanosensitive ion channel
Theam_0833	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Theam_0834	ENOG41081FY	multiple antibiotic resistance (MarC)-related
Theam_0835	ENOG4105C4G	Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity)
Theam_0838	ENOG4105C3G	gtp-binding protein
Theam_0840	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Theam_0842	ENOG4105YAZ	4-amino-4-deoxychorismate lyase
Theam_0843	ENOG4108VYJ	response regulator receiver protein
Theam_0844	ENOG4107R88	Chemotaxis protein (CheV)
Theam_0846	ENOG4105YVF	chew protein
Theam_0847	ENOG4105CBS	Chea signal transduction histidine kinase
Theam_0849	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Theam_0850	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Theam_0852	ENOG4105CPF	Cell wall formation (By similarity)
Theam_0854	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Theam_0857	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Theam_0858	ENOG4107Z3H	Transcriptional regulator, TetR family
Theam_0859	ENOG4108IG5	Transcriptional regulator
Theam_0860	ENOG4105CW7	secretion protein, HlyD family
Theam_0861	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Theam_0864	ENOG4105CJ1	ABC, transporter
Theam_0868	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
Theam_0870	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
Theam_0872	ENOG410695F	Crispr-associated protein, Csm1 family
Theam_0873	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Theam_0876	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Theam_0877	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Theam_0881	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Theam_0882	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Theam_0883	ENOG4105C19	ABC transporter
Theam_0884	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Theam_0885	ENOG4107QYG	anthranilate phosphoribosyltransferase
Theam_0887	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Theam_0890	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Theam_0894	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Theam_0897	ENOG4107QHF	type ii secretion system protein e
Theam_0898	ENOG4105D7Q	type ii secretion system
Theam_0903	ENOG4105E4G	Type IV pilus
Theam_0905	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Theam_0906	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
Theam_0910	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Theam_0911	ENOG4105EA8	2-Nitropropane dioxygenase
Theam_0912	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Theam_0913	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Theam_0914	ENOG41085D1	50S ribosomal protein L32
Theam_0917	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Theam_0920	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Theam_0921	ENOG4105KNE	Phosphatidate cytidylyltransferase
Theam_0923	ENOG4105C4B	ABC transporter, permease
Theam_0927	ENOG410890F	Dynamin family
Theam_0929	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Theam_0936	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Theam_0938	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
Theam_0942	ENOG4107QNG	Phosphoribosylglycinamide synthetase
Theam_0943	ENOG4105E4C	Lytic transglycosylase catalytic
Theam_0944	ENOG4105D07	Signal peptide peptidase, SppA
Theam_0945	ENOG4107FSS	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Theam_0950	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Theam_0954	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Theam_0955	ENOG4108RWI	nicotinamidase
Theam_0957	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Theam_0958	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Theam_0959	ENOG4105CNI	cell division protein FtsW
Theam_0962	ENOG4105C1V	Peptidase, M16
Theam_0967	ENOG4105BZ8	glutamate synthase
Theam_0968	ENOG4105KST	dependent repressor
Theam_0969	ENOG4105DVY	radical SAM domain protein
Theam_0970	ENOG4105DVY	radical SAM domain protein
Theam_0972	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Theam_0973	ENOG4105C5I	Dehydrogenase
Theam_0974	ENOG4107QP8	phosphohexose isomerase
Theam_0975	ENOG4105CV9	cyclopropane-fatty-acyl-phospholipid synthase
Theam_0978	ENOG4105C6W	4-alpha-glucanotransferase (EC 2.4.1.25)
Theam_0980	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Theam_0982	ENOG4107RFW	hydrolase family 57
Theam_0983	ENOG4105DKQ	ROK family
Theam_0984	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Theam_0985	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Theam_0988	ENOG4105CG2	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)
Theam_0989	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Theam_0990	ENOG4105CZX	twitching motility protein
Theam_0992	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Theam_0993	ENOG4108ZXC	Two component transcriptional regulator, luxr family
Theam_0994	ENOG4105C6E	dna polymerase iii
Theam_0998	ENOG4105CBC	glutamate synthase
Theam_0999	ENOG4108XIB	electron transport protein ysaA
Theam_1001	ENOG4105EYU	Glutamine amido-transferase
Theam_1003	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Theam_1004	ENOG4105BZU	Histidine kinase
Theam_1005	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Theam_1006	ENOG4108Z1Z	gCN5-related N-acetyltransferase
Theam_1007	ENOG4105D60	lipoprotein releasing system transmembrane protein
Theam_1008	ENOG4105CRK	lysyL-tRNA synthetase
Theam_1009	ENOG4105CY3	ABC transporter, permease
Theam_1011	ENOG4107KIA	Virulence factor Mce family protein
Theam_1012	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Theam_1015	ENOG4105CFX	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Theam_1016	ENOG4105C1Q	protoporphyrinogen oxidase
Theam_1017	ENOG4105C83	adenylosuccinate lyase
Theam_1019	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Theam_1020	ENOG4108IEG	Formate dehydrogenase Alpha subunit
Theam_1021	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Theam_1023	ENOG4105E9K	Isocitrate dehydrogenase
Theam_1024	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Theam_1026	ENOG4105E0Y	RtcB Protein
Theam_1030	ENOG41080XP	Cbs domain
Theam_1031	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Theam_1032	ENOG4105C7N	Xanthine uracil vitamin C permease
Theam_1033	ENOG4105D0M	Protease HtpX homolog
Theam_1035	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Theam_1036	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Theam_1039	ENOG4107QI1	Mate efflux family protein
Theam_1040	ENOG4105ES5	Histidine kinase
Theam_1041	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Theam_1042	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Theam_1045	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Theam_1048	ENOG4105BZU	Histidine kinase
Theam_1049	ENOG4105K59	histidine triad (HIT) protein
Theam_1050	ENOG4105CJN	penicillin-binding protein
Theam_1052	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Theam_1053	ENOG4105CR7	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)
Theam_1055	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Theam_1056	ENOG4108V1U	phospholipid-binding protein
Theam_1057	ENOG4105CY0	Metallo-Beta-Lactamase
Theam_1060	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Theam_1063	ENOG4105DCG	PHP domain protein
Theam_1066	ENOG4105DFA	alanine racemase domain protein
Theam_1067	ENOG4106M32	3-dehydroquinate synthase
Theam_1069	ENOG4105CUI	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity)
Theam_1070	ENOG4105KV4	Transcriptional regulator
Theam_1071	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Theam_1075	ENOG4105DZH	s-adenosylmethionine synthetase (EC 2.5.1.6)
Theam_1076	ENOG4105C7Z	Conserved Protein
Theam_1077	ENOG4105CK3	Lysine 2,3-aminomutase YodO family protein
Theam_1081	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Theam_1082	ENOG4105K4H	Nlp p60 protein
Theam_1083	ENOG4105C0H	protease
Theam_1084	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Theam_1085	ENOG4106VK6	Flagellar motor protein
Theam_1086	ENOG4106VK6	Flagellar motor protein
Theam_1087	ENOG4108217	motA TolQ ExbB proton channel
Theam_1088	ENOG4105CQB	FAD linked oxidase domain protein
Theam_1092	ENOG4105E3R	(LipO)protein
Theam_1093	ENOG4105CJR	Integral membrane protein (MviN
Theam_1094	ENOG4107XN1	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Theam_1095	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Theam_1098	ENOG4108VAU	general secretion pathway protein G
Theam_1099	ENOG4105C2N	RNA methyltransferase TrmH family group 3
Theam_1101	ENOG4105CUX	Signal transduction histidine kinase
Theam_1102	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Theam_1106	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Theam_1107	ENOG4105CGK	Exodeoxyribonuclease III
Theam_1109	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Theam_1110	ENOG4105E4C	Lytic transglycosylase catalytic
Theam_1111	ENOG4105CDY	transcriptional regulatory protein
Theam_1112	ENOG4105MRR	Transcriptional regulator (By similarity)
Theam_1115	ENOG4105C75	arginyL-tRNA synthetase
Theam_1121	ENOG4105E3S	small subunit
Theam_1122	ENOG4105DPX	Hydrogenase, large subunit
Theam_1124	ENOG4108USZ	hydrogenase
Theam_1125	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
Theam_1126	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Theam_1127	ENOG4107QNM	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) (By similarity)
Theam_1131	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
Theam_1132	ENOG4105VCQ	rubredoxin
Theam_1133	ENOG4105CNW	domain protein
Theam_1138	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Theam_1139	ENOG4105F4P	)-transporter
Theam_1140	ENOG4108JQC	penicillin-binding protein 1A
Theam_1141	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Theam_1142	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Theam_1150	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Theam_1151	ENOG4108IUZ	ABC transporter
Theam_1154	ENOG4108Z4R	3-deoxy-d-manno-octulosonate 8-phosphate phosphatase
Theam_1156	ENOG4105CA0	peroxidase
Theam_1157	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
Theam_1159	ENOG4105MQ3	flagellar protein FliS
Theam_1160	ENOG410804A	Flagellar hook-associated 2 domain-containing protein
Theam_1162	ENOG4105I03	Flagellin
Theam_1163	ENOG4107TVC	Glycosyl transferase, family 2
Theam_1166	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Theam_1168	ENOG4105C31	Tryptophanyl-tRNA synthetase
Theam_1176	ENOG4105CJN	penicillin-binding protein
Theam_1177	ENOG4105C22	threonyL-tRNA synthetase
Theam_1178	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Theam_1180	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Theam_1182	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Theam_1184	ENOG4106H78	methyltransferase
Theam_1186	ENOG4107QRA	Extracellular solute-binding protein, family 5
Theam_1188	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Theam_1189	ENOG4105CAT	Cytidine monophosphate kinase
Theam_1191	ENOG4105CSM	endonuclease III
Theam_1192	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Theam_1194	ENOG4105FE9	pseudouridine synthase
Theam_1195	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Theam_1197	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Theam_1200	ENOG4105FE9	pseudouridine synthase
Theam_1203	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Theam_1204	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Theam_1207	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Theam_1208	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Theam_1211	ENOG4108HH9	Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR
Theam_1212	ENOG4108HW8	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
Theam_1213	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Theam_1218	ENOG4108YZG	isomerase
Theam_1219	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Theam_1221	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Theam_1222	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Theam_1226	ENOG4105DB1	molybdopterin oxidoreductase
Theam_1228	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Theam_1229	ENOG4108KVX	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)
Theam_1231	ENOG4105E4C	Lytic transglycosylase catalytic
Theam_1232	ENOG4105HEE	Binding Domain protein
Theam_1235	ENOG4105ECY	inositol monophosphatase
Theam_1238	ENOG4105BZU	Histidine kinase
Theam_1240	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Theam_1242	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Theam_1244	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Theam_1247	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Theam_1249	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Theam_1250	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Theam_1252	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Theam_1253	ENOG4105BZU	Histidine kinase
Theam_1257	ENOG4108UKJ	Cdp-alcohol phosphatidyltransferase
Theam_1258	ENOG4105C02	permease
Theam_1259	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Theam_1260	ENOG4105D48	metallophosphoesterase
Theam_1261	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Theam_1264	ENOG41082I2	s4 domain protein
Theam_1265	ENOG4105CEY	Amp-dependent synthetase and ligase
Theam_1266	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Theam_1267	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Theam_1268	ENOG4105CSM	endonuclease III
Theam_1269	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Theam_1271	ENOG4105E33	succinate dehydrogenase
Theam_1272	ENOG4108J01	L-aspartate oxidase
Theam_1273	ENOG4105C00	Succinate dehydrogenase (Flavoprotein subunit)
Theam_1274	ENOG4105E33	succinate dehydrogenase
Theam_1275	ENOG41086B8	CoB-CoM heterodisulfide reductase
Theam_1278	ENOG4105C8P	)-transporter
Theam_1281	ENOG4106MP8	UPF0754 membrane protein
Theam_1282	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Theam_1287	ENOG4105KHV	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Theam_1289	ENOG4105CKK	Glycosyl transferase, family 2
Theam_1290	ENOG4107SH3	glycosyl transferase, family 39
Theam_1293	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Theam_1296	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Theam_1298	ENOG4105K5M	30s ribosomal protein S16
Theam_1299	ENOG4105VB6	UPF0109 protein
Theam_1301	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Theam_1303	ENOG4105C5X	domain protein
Theam_1308	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
Theam_1310	ENOG4107S2Z	UPF0761 membrane protein
Theam_1312	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Theam_1313	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Theam_1316	ENOG4107S47	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)
Theam_1319	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
Theam_1321	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Theam_1323	ENOG4105CZI	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Theam_1324	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Theam_1326	ENOG4105W49	UPF0434 protein
Theam_1327	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Theam_1328	ENOG4105CXT	aspartate transcarbamylase
Theam_1330	ENOG4105CD3	dihydroorotase
Theam_1333	ENOG4105CTP	PilT protein domain protein
Theam_1334	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Theam_1335	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
Theam_1336	ENOG4105VXR	cytoplasmic protein
Theam_1341	ENOG4107ZMQ	sugar fermentation stimulation protein
Theam_1342	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Theam_1343	ENOG4105BZ8	glutamate synthase
Theam_1344	ENOG4108WTY	tRNA (Guanine-N(1)-)-methyltransferase
Theam_1345	ENOG4105CNK	Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)
Theam_1347	ENOG4105E7H	involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)
Theam_1350	ENOG4105DA5	(ABC) transporter
Theam_1351	ENOG4106855	Competence protein
Theam_1354	ENOG4105CY0	Metallo-Beta-Lactamase
Theam_1355	ENOG4105K63	Thioredoxin
Theam_1364	ENOG4105EUJ	GTP cyclohydrolase i
Theam_1365	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Theam_1366	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Theam_1367	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
Theam_1368	ENOG4105CDH	Citrulline--aspartate ligase
Theam_1369	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Theam_1370	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Theam_1371	ENOG4105E0F	Histidine kinase
Theam_1372	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Theam_1373	ENOG4108ZVP	Domain of unknown function (DUF1931)
Theam_1378	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Theam_1385	ENOG4105E1Q	flagellar hook-associated protein
Theam_1389	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
Theam_1390	ENOG4105CXV	gliding motility protein
Theam_1392	ENOG4105DDK	oxidoreductase, beta subunit
Theam_1393	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Theam_1394	ENOG4105WGB	oxidoreductase, delta subunit
Theam_1395	ENOG4105EJ5	oxidoreductase gamma subunit
Theam_1396	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Theam_1397	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Theam_1398	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Theam_1401	ENOG4105DSJ	YicC domain protein
Theam_1402	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Theam_1403	ENOG4105VFG	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Theam_1404	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Theam_1405	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Theam_1407	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Theam_1408	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Theam_1409	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Theam_1411	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Theam_1412	ENOG4105DQU	oxidoreductase, subunit beta
Theam_1418	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Theam_1421	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Theam_1424	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Theam_1429	ENOG4105C0D	helicase
Theam_1430	ENOG4105F0N	pyrophosphate phospho-hydrolase
Theam_1433	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Theam_1437	ENOG4105FGP	Type IV pilus assembly
Theam_1440	ENOG4105D00	flagellar biosynthetic protein flhB
Theam_1441	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Theam_1442	ENOG4105VS8	Flagellar biosynthetic protein fliq
Theam_1443	ENOG4105CN7	Flagellar biosynthetic protein FliP
Theam_1445	ENOG4105X6C	Flagellar basal body-associated protein FliL
Theam_1446	ENOG4105BZE	flagellar hook protein, FlgE
Theam_1447	ENOG410822I	Flagellar hook capping protein
Theam_1450	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Theam_1451	ENOG4105VQ0	flagellar hook-basal body complex protein fliE
Theam_1452	ENOG4108ZC9	flagellar basal-body rod protein flgc
Theam_1453	ENOG41083MZ	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
Theam_1456	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Theam_1458	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Theam_1459	ENOG4105D7B	Flagellar biosynthesis protein flha
Theam_1461	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Theam_1462	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Theam_1464	ENOG4105CGA	flagellar basal-body rod protein FlgG
Theam_1465	ENOG4105CGA	flagellar basal-body rod protein FlgG
Theam_1467	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Theam_1468	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Theam_1470	ENOG4108J9M	Transporter
Theam_1471	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Theam_1472	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Theam_1473	ENOG4105KJP	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Theam_1474	ENOG4105C3M	thioredoxin reductase
Theam_1475	ENOG4105K63	Thioredoxin
Theam_1477	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
Theam_1478	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Theam_1479	ENOG4105CZA	synthase
Theam_1483	ENOG4105EWC	Purine nucleoside phosphorylase
Theam_1484	ENOG4105C1V	Peptidase, M16
Theam_1485	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Theam_1486	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Theam_1487	ENOG4105EQI	Metal Dependent Phosphohydrolase
Theam_1488	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_1490	ENOG4105D65	subunit l
Theam_1494	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Theam_1495	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_1496	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_1497	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Theam_1499	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Theam_1500	ENOG4105E2Z	phosphate ABC transporter (Permease
Theam_1501	ENOG4105C8U	phosphate abc transporter
Theam_1502	ENOG4105C0B	DNA polymerase III (alpha subunit)
Theam_1503	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Theam_1504	ENOG4105DHT	Metal Dependent Phosphohydrolase
Theam_1505	ENOG4105C1J	atp-dependent rna helicase
Theam_1509	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Theam_1510	ENOG4108JQ1	Dehydrogenase
Theam_1511	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Theam_1512	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Theam_1517	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Theam_1519	ENOG4105DXN	mazG family
Theam_1520	ENOG4105C8N	cysteinyl-tRNA synthetase
Theam_1524	ENOG4108A51	
Theam_1525	ENOG4107XQ1	cobalamin (vitamin B12) biosynthesis CbiM protein
Theam_1530	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Theam_1531	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Theam_1539	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Theam_1540	ENOG4107QSA	Oxaloacetate decarboxylase
Theam_1542	ENOG4105C0P	Mg chelatase subunit ChlI
Theam_1544	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Theam_1545	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Theam_1546	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Theam_1548	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Theam_1550	ENOG4105DE4	1-phosphofructokinase
Theam_1551	ENOG4105BZU	Histidine kinase
Theam_1552	ENOG4105E05	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Theam_1555	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Theam_1556	ENOG4107YX5	Pfam:DUF548
Theam_1560	ENOG4105C8Q	Methyl-accepting chemotaxis
Theam_1561	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
Theam_1562	ENOG4105EIZ	Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)
Theam_1566	ENOG4107YD3	Thioesterase
Theam_1567	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Theam_1569	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Theam_1572	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Theam_1573	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Theam_1575	ENOG4105E4C	Lytic transglycosylase catalytic
Theam_1577	ENOG4105CPN	adenine deaminase
Theam_1578	ENOG4107QR0	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Theam_1580	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Theam_1581	ENOG4108VZM	50s ribosomal protein L10
Theam_1582	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Theam_1583	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Theam_1584	ENOG4107WP1	Participates in transcription elongation, termination and antitermination (By similarity)
Theam_1585	ENOG410683Z	Preprotein translocase SecE subunit
Theam_1586	ENOG4105WDJ	50S ribosomal protein L33
Theam_1587	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Theam_1591	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Theam_1595	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Theam_1596	ENOG4105CQC	Prephenate dehydratase
Theam_1598	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Theam_1600	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Theam_1605	ENOG4107WJT	it plays a direct role in the translocation of protons across the membrane (By similarity)
Theam_1606	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Theam_1608	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
Theam_1610	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Theam_1612	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Theam_1619	ENOG4105DTT	CRISPR-associated helicase, cas3
Theam_1622	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Theam_1625	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Theam_1627	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Theam_1628	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Theam_1629	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
Theam_1632	ENOG4105FD2	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)
Theam_1634	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Theam_1638	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Theam_1639	ENOG4107BJW	polysaccharide deacetylase
Theam_1640	ENOG4106WTF	Glycosyl transferase, family 2
Theam_1641	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Theam_1644	ENOG4105C25	Primosomal protein n'
Theam_1647	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Theam_1648	ENOG4105VB5	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Theam_1651	ENOG4107Y66	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Theam_1655	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Theam_1656	ENOG4108Q71	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)
Theam_1658	ENOG4105E3N	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Theam_1659	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
Theam_1660	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
Theam_1661	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
Theam_1662	ENOG410825K	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Theam_1664	ENOG4107RY6	amino acid
Theam_1667	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
Theam_1668	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Theam_1669	ENOG4108215	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Theam_1672	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Theam_1676	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Theam_1677	ENOG4108Z6B	deaminase
Theam_1678	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Theam_1679	ENOG4105CZX	twitching motility protein
Theam_1682	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Theam_1688	ENOG4105CHV	Transcription elongation factor NusA
Theam_1689	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Theam_1690	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Theam_1691	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Theam_1692	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Theam_1694	ENOG4108U9A	
Theam_1695	ENOG4105BZU	Histidine kinase
Theam_1696	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Theam_1697	ENOG4105DBV	ornithine carbamoyltransferase
Theam_1702	ENOG4105CSA	Coproporphyrinogen iii oxidase
Theam_1712	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Theam_1713	ENOG4108UM1	dedA family
Theam_1716	ENOG4105DZP	Membrane-associated zinc metalloprotease
Theam_1717	ENOG4105DX0	Hemolysin A
Theam_1723	ENOG4105VB9	50S ribosomal protein l28
Theam_1725	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Theam_1726	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Theam_1745	ENOG4105BZU	Histidine kinase
Theam_1748	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Theam_1762	ENOG4105DZP	Membrane-associated zinc metalloprotease
Theam_1763	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Theam_1799	ENOG4107QHF	type ii secretion system protein e
Theam_1804	ENOG4107QHF	type ii secretion system protein e
Theam_1812	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Theam_1825	ENOG4105GMT	ATPase associated with various cellular activities aaa_5
Theam_1831	ENOG4105Z8H	single-stranded DNA-binding protein