locus-tag	class	description
Theam_0001	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Theam_0002	COG0305	Participates in initiation and elongation during chromosome replication
Theam_0004	COG0442	prolyl-tRNA aminoacylation
Theam_0005	COG0297	glycogen (starch) synthase activity
Theam_0005	COG0438	transferase activity, transferring glycosyl groups
Theam_0006	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Theam_0007	COG0592	DNA-directed DNA polymerase activity
Theam_0009	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Theam_0010	COG0142	geranyltranstransferase activity
Theam_0011	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Theam_0038	COG0776	regulation of translation
Theam_0068	COG0730	response to heat
Theam_0071	COG0288	reversible hydration of carbon dioxide
Theam_0073	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Theam_0075	COG0107	imidazoleglycerol-phosphate synthase activity
Theam_0076	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Theam_0077	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
Theam_0079	COG1473	amidohydrolase
Theam_0080	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Theam_0081	COG0142	geranyltranstransferase activity
Theam_0085	COG1196	nuclear chromosome segregation
Theam_0087	COG4231	catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates
Theam_0088	COG0233	cytoplasmic translational termination
Theam_0089	COG0528	UMP kinase activity
Theam_0090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Theam_0091	COG0052	Belongs to the universal ribosomal protein uS2 family
Theam_0094	COG2226	methyltransferase
Theam_0096	COG0730	response to heat
Theam_0098	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Theam_0100	COG3679	Belongs to the UPF0342 family
Theam_0104	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Theam_0104	COG0426	domain, Protein
Theam_0107	COG1994	Peptidase M50
Theam_0108	COG2078	PFAM AMMECR1 domain protein
Theam_0109	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Theam_0111	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Theam_0113	COG1100	Small GTP-binding protein
Theam_0119	COG1242	4 iron, 4 sulfur cluster binding
Theam_0121	COG0799	negative regulation of ribosome biogenesis
Theam_0123	COG1530	ribonuclease E activity
Theam_0132	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Theam_0133	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Theam_0134	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Theam_0136	COG0740	serine-type endopeptidase activity
Theam_0137	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Theam_0137	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Theam_0140	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Theam_0141	COG3174	membrane
Theam_0142	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Theam_0143	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Theam_0145	COG0517	IMP dehydrogenase activity
Theam_0145	COG0516	GMP reductase activity
Theam_0146	COG0165	Argininosuccinate lyase
Theam_0147	COG3959	Transketolase, thiamine diphosphate binding domain
Theam_0148	COG3958	Transketolase
Theam_0149	COG0793	Belongs to the peptidase S41A family
Theam_0150	COG1073	alpha beta
Theam_0150	COG2226	methyltransferase
Theam_0151	COG1660	Displays ATPase and GTPase activities
Theam_0153	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Theam_0155	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Theam_0158	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Theam_0159	COG0167	dihydroorotate dehydrogenase activity
Theam_0160	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Theam_0163	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Theam_0165	COG0840	transmembrane signaling receptor activity
Theam_0166	COG3706	GGDEF domain
Theam_0166	COG0745	RESPONSE REGULATOR receiver
Theam_0168	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Theam_0170	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Theam_0171	COG0519	Catalyzes the synthesis of GMP from XMP
Theam_0171	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Theam_0177	COG0758	DNA mediated transformation
Theam_0179	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Theam_0180	COG0124	histidyl-tRNA synthetase
Theam_0181	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Theam_0184	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Theam_0186	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Theam_0189	COG0284	orotidine-5'-phosphate decarboxylase activity
Theam_0191	COG0436	Aminotransferase
Theam_0193	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theam_0194	COG1120	ATPase activity
Theam_0196	COG1091	dTDP-4-dehydrorhamnose reductase activity
Theam_0198	COG0583	DNA-binding transcription factor activity
Theam_0201	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Theam_0205	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Theam_0206	COG0126	phosphoglycerate kinase activity
Theam_0210	COG1388	LysM domain
Theam_0211	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Theam_0212	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Theam_0212	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Theam_0213	COG1078	dGTPase activity
Theam_0214	COG0735	belongs to the Fur family
Theam_0215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Theam_0218	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Theam_0220	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Theam_0221	COG0511	ligase activity, forming carbon-carbon bonds
Theam_0222	COG0439	Biotin carboxylase
Theam_0227	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Theam_0228	COG1047	Peptidyl-prolyl cis-trans
Theam_0229	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Theam_0230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Theam_0231	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Theam_0233	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Theam_0234	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Theam_0235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Theam_0236	COG0644	oxidoreductase
Theam_0237	COG0505	Belongs to the CarA family
Theam_0239	COG0512	Glutamine amidotransferase of anthranilate synthase
Theam_0240	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Theam_0244	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Theam_0245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Theam_0246	COG1185	polyribonucleotide nucleotidyltransferase activity
Theam_0247	COG0756	dUTP diphosphatase activity
Theam_0250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Theam_0252	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Theam_0253	COG0049	tRNA binding
Theam_0254	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Theam_0255	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Theam_0256	COG0051	transcription antitermination factor activity, RNA binding
Theam_0257	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Theam_0258	COG0088	Forms part of the polypeptide exit tunnel
Theam_0259	COG0089	rRNA binding
Theam_0260	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Theam_0261	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Theam_0262	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Theam_0263	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Theam_0264	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Theam_0266	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Theam_0267	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Theam_0268	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Theam_0269	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Theam_0271	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Theam_0272	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Theam_0273	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Theam_0274	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Theam_0275	COG1841	ribosomal large subunit assembly
Theam_0276	COG0200	Binds to the 23S rRNA
Theam_0277	COG0201	protein transport
Theam_0278	COG0563	adenylate kinase activity
Theam_0280	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Theam_0281	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Theam_0282	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Theam_0283	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Theam_0284	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Theam_0285	COG0202	RNA polymerase activity
Theam_0286	COG0203	ribosomal protein L17
Theam_0288	COG2894	cell division
Theam_0289	COG0850	regulation of cytokinetic process
Theam_0290	COG0010	Belongs to the arginase family
Theam_0291	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Theam_0295	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Theam_0297	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Theam_0298	COG0193	aminoacyl-tRNA hydrolase activity
Theam_0299	COG0360	Binds together with S18 to 16S ribosomal RNA
Theam_0300	COG0629	single-stranded DNA binding
Theam_0301	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Theam_0303	COG0359	binds to the 23S rRNA
Theam_0305	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Theam_0306	COG0251	oxidation-reduction process
Theam_0307	COG0640	Transcriptional regulator
Theam_0308	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Theam_0310	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Theam_0315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Theam_0319	COG0348	domain, Protein
Theam_0324	COG0295	cytidine deaminase activity
Theam_0327	COG0069	glutamate synthase activity
Theam_0327	COG0070	glutamate synthase
Theam_0327	COG0067	glutamate synthase
Theam_0328	COG0138	bifunctional purine biosynthesis protein purh
Theam_0329	COG0330	HflC and HflK could
Theam_0332	COG2264	protein methyltransferase activity
Theam_0333	COG0613	PHP domain protein
Theam_0336	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Theam_0337	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Theam_0338	COG0006	proline dipeptidase activity
Theam_0341	COG1337	RAMP superfamily
Theam_0345	COG0343	queuine tRNA-ribosyltransferase activity
Theam_0347	COG0066	3-isopropylmalate dehydratase activity
Theam_0348	COG0473	3-isopropylmalate dehydrogenase activity
Theam_0349	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Theam_0353	COG1254	Belongs to the acylphosphatase family
Theam_0354	COG0791	NLP P60 protein
Theam_0354	COG1388	LysM domain
Theam_0356	COG0569	domain protein
Theam_0357	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Theam_0358	COG1333	cytochrome c biogenesis protein
Theam_0359	COG0402	S-adenosylhomocysteine deaminase activity
Theam_0360	COG0617	tRNA 3'-terminal CCA addition
Theam_0362	COG0542	response to heat
Theam_0363	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Theam_0365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Theam_0365	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Theam_0366	COG0840	transmembrane signaling receptor activity
Theam_0369	COG0564	pseudouridine synthase activity
Theam_0371	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Theam_0373	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Theam_0374	COG0527	aspartate kinase activity
Theam_0375	COG0303	'Molybdopterin
Theam_0377	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Theam_0378	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Theam_0379	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Theam_0381	COG1420	regulation of RNA biosynthetic process
Theam_0382	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Theam_0385	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Theam_0386	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Theam_0389	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Theam_0390	COG0736	holo-[acyl-carrier-protein] synthase activity
Theam_0392	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Theam_0393	COG1028	Short-chain dehydrogenase reductase Sdr
Theam_0399	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Theam_0400	COG0668	transmembrane transport
Theam_0404	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Theam_0406	COG0859	PFAM glycosyl transferase family 9
Theam_0410	COG2197	response regulator
Theam_0411	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Theam_0412	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Theam_0413	COG0475	glutathione-regulated potassium exporter activity
Theam_0416	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Theam_0417	COG1774	PSP1 C-terminal conserved region
Theam_0423	COG0243	molybdopterin cofactor binding
Theam_0426	COG3901	Regulator of nitric oxide reductase transcription
Theam_0426	COG0348	domain, Protein
Theam_0428	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Theam_0429	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Theam_0431	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Theam_0434	COG0254	rRNA binding
Theam_0435	COG0586	Pfam SNARE associated Golgi protein
Theam_0436	COG0159	tryptophan synthase activity
Theam_0437	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Theam_0438	COG0805	protein transport
Theam_0439	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Theam_0440	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Theam_0441	COG1830	Aldolase
Theam_0443	COG0475	glutathione-regulated potassium exporter activity
Theam_0443	COG0569	domain protein
Theam_0444	COG0569	domain protein
Theam_0446	COG0719	Fe-S assembly protein
Theam_0448	COG0307	riboflavin synthase, alpha
Theam_0450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Theam_0452	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Theam_0453	COG0601	transmembrane transport
Theam_0454	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Theam_0455	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Theam_0457	COG1045	serine acetyltransferase
Theam_0459	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Theam_0460	COG0440	acetolactate synthase activity
Theam_0461	COG0028	Belongs to the TPP enzyme family
Theam_0462	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Theam_0464	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Theam_0464	COG0517	IMP dehydrogenase activity
Theam_0471	COG0594	ribonuclease P activity
Theam_0472	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Theam_0473	COG0706	membrane insertase activity
Theam_0474	COG4536	flavin adenine dinucleotide binding
Theam_0475	COG1253	flavin adenine dinucleotide binding
Theam_0476	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_0478	COG0649	NAD binding
Theam_0480	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_0481	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Theam_0482	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Theam_0482	COG2111	Na H antiporter
Theam_0484	COG3259	Nickel-dependent hydrogenase
Theam_0485	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Theam_0486	COG0543	2 iron, 2 sulfur cluster binding
Theam_0488	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Theam_0489	COG1012	belongs to the aldehyde dehydrogenase family
Theam_0491	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Theam_0493	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Theam_0495	COG1294	oxidase, subunit
Theam_0500	COG1923	regulation of RNA biosynthetic process
Theam_0501	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Theam_0502	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Theam_0503	COG2257	FlhB HrpN YscU SpaS Family
Theam_0506	COG0181	hydroxymethylbilane synthase activity
Theam_0507	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Theam_0508	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Theam_0509	COG0710	3-dehydroquinate dehydratase activity
Theam_0510	COG1993	acr, cog1993
Theam_0511	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Theam_0513	COG0860	N-Acetylmuramoyl-L-alanine amidase
Theam_0514	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Theam_0519	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Theam_0520	COG0113	porphobilinogen synthase activity
Theam_0522	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Theam_0522	COG0426	domain, Protein
Theam_0523	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Theam_0524	COG1610	YqeY-like protein
Theam_0525	COG1193	negative regulation of DNA recombination
Theam_0526	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Theam_0529	COG0531	amino acid
Theam_0530	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Theam_0534	COG0129	dihydroxy-acid dehydratase activity
Theam_0536	COG0456	acetyltransferase
Theam_0537	COG1214	PFAM Peptidase M22, glycoprotease
Theam_0538	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Theam_0540	COG4581	dead DEAH box helicase
Theam_0548	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Theam_0549	COG0556	nucleotide-excision repair
Theam_0550	COG0675	Transposase, IS605 OrfB family
Theam_0557	COG0569	domain protein
Theam_0558	COG0436	Aminotransferase
Theam_0559	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theam_0561	COG0003	Pfam Anion-transporting ATPase
Theam_0564	COG1663	tetraacyldisaccharide 4'-kinase activity
Theam_0565	COG1519	Transferase
Theam_0568	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Theam_0569	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Theam_0570	COG0124	histidyl-tRNA synthetase
Theam_0571	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Theam_0573	COG3287	FIST C domain
Theam_0573	COG2200	EAL domain
Theam_0573	COG2199	diguanylate cyclase activity
Theam_0575	COG0463	Glycosyl transferase, family 2
Theam_0575	COG1216	Glycosyl transferase, family 2
Theam_0576	COG2813	Specifically methylates the guanine in position
Theam_0577	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Theam_0578	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
Theam_0580	COG1091	dTDP-4-dehydrorhamnose reductase activity
Theam_0581	COG0123	including yeast histone deacetylase and acetoin utilization protein
Theam_0582	COG0557	exoribonuclease II activity
Theam_0586	COG0148	phosphopyruvate hydratase activity
Theam_0588	COG0848	biopolymer transport protein
Theam_0589	COG0436	Aminotransferase
Theam_0591	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Theam_0592	COG0268	Binds directly to 16S ribosomal RNA
Theam_0593	COG0352	thiamine-phosphate diphosphorylase activity
Theam_0595	COG0438	transferase activity, transferring glycosyl groups
Theam_0597	COG0726	polysaccharide deacetylase
Theam_0598	COG1132	(ABC) transporter
Theam_0600	COG0438	transferase activity, transferring glycosyl groups
Theam_0602	COG0039	L-malate dehydrogenase activity
Theam_0603	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Theam_0604	COG2226	methyltransferase
Theam_0605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Theam_0607	COG3706	GGDEF domain
Theam_0608	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Theam_0609	COG0646	methionine synthase
Theam_0609	COG1410	methionine synthase
Theam_0610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Theam_0611	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Theam_0612	COG0571	ribonuclease III activity
Theam_0613	COG0424	maF-like protein
Theam_0615	COG0745	RESPONSE REGULATOR receiver
Theam_0616	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Theam_0617	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Theam_0618	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Theam_0619	COG1234	tRNA 3'-trailer cleavage
Theam_0620	COG1618	nucleotide phosphatase activity, acting on free nucleotides
Theam_0621	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Theam_0626	COG0004	ammonium transporteR
Theam_0628	COG0347	Belongs to the P(II) protein family
Theam_0629	COG0174	glutamine synthetase
Theam_0631	COG0019	diaminopimelate decarboxylase activity
Theam_0633	COG0287	Prephenate dehydrogenase
Theam_0638	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Theam_0639	COG0037	tRNA processing
Theam_0640	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Theam_0640	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Theam_0641	COG2003	Belongs to the UPF0758 family
Theam_0642	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Theam_0645	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Theam_0646	COG0101	tRNA pseudouridine synthase activity
Theam_0647	COG0475	glutathione-regulated potassium exporter activity
Theam_0647	COG0569	domain protein
Theam_0648	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Theam_0649	COG0405	Gamma-glutamyltransferase
Theam_0652	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Theam_0654	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Theam_0655	COG0149	triose-phosphate isomerase activity
Theam_0656	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Theam_0657	COG0135	phosphoribosylanthranilate isomerase activity
Theam_0661	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Theam_0663	COG1218	3'(2'),5'-bisphosphate nucleotidase
Theam_0664	COG0471	metal ion transport
Theam_0664	COG3273	potassium ion transport
Theam_0665	COG0529	Catalyzes the synthesis of activated sulfate
Theam_0666	COG2046	Belongs to the sulfate adenylyltransferase family
Theam_0669	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
Theam_0669	COG1215	transferase activity, transferring glycosyl groups
Theam_0674	COG0438	transferase activity, transferring glycosyl groups
Theam_0676	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Theam_0677	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Theam_0681	COG1309	transcriptional regulator
Theam_0682	COG1924	4 iron, 4 sulfur cluster binding
Theam_0684	COG1966	Carbon starvation protein
Theam_0688	COG0704	Plays a role in the regulation of phosphate uptake
Theam_0689	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Theam_0691	COG0431	NADPH-dependent FMN reductase
Theam_0692	COG1160	GTP binding
Theam_0697	COG1730	sister chromatid segregation
Theam_0698	COG1332	CRISPR-associated RAMP protein, Csm5 family
Theam_0699	COG1851	Uncharacterised protein family (UPF0128)
Theam_0701	COG1509	lysine 2,3-aminomutase activity
Theam_0704	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Theam_0707	COG1040	competence protein
Theam_0708	COG4608	Belongs to the ABC transporter superfamily
Theam_0710	COG1162	GTPase activity
Theam_0713	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Theam_0714	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Theam_0715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Theam_0717	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Theam_0718	COG0504	CTP synthase activity
Theam_0719	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Theam_0720	COG0047	phosphoribosylformylglycinamidine synthase activity
Theam_0721	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Theam_0723	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Theam_0724	COG0358	DNA primase activity
Theam_0725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Theam_0726	COG0564	pseudouridine synthase activity
Theam_0729	COG1388	LysM domain
Theam_0729	COG1705	Flagellar rod assembly protein muramidase FlgJ
Theam_0730	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Theam_0730	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Theam_0731	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_0732	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_0733	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_0735	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Theam_0738	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Theam_0739	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Theam_0740	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_0741	COG0839	Belongs to the complex I subunit 6 family
Theam_0745	COG1007	ATP synthesis coupled electron transport
Theam_0746	COG1921	L-seryl-tRNASec selenium transferase activity
Theam_0747	COG4771	TonB-dependent receptor
Theam_0749	COG3706	GGDEF domain
Theam_0751	COG1652	LysM domain
Theam_0756	COG0312	modulator of DNA gyrase
Theam_0761	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Theam_0762	COG1480	7TM receptor with intracellular HD hydrolase
Theam_0763	COG1702	phosphate starvation-inducible protein PhoH
Theam_0764	COG3264	Mechanosensitive ion channel
Theam_0764	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Theam_0765	COG0488	(ABC) transporter
Theam_0767	COG0733	neurotransmitter:sodium symporter activity
Theam_0768	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Theam_0768	COG0731	radical SAM domain protein
Theam_0769	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Theam_0770	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Theam_0772	COG0312	modulator of DNA gyrase
Theam_0773	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Theam_0785	COG0303	'Molybdopterin
Theam_0788	COG4149	molybdate abc transporter
Theam_0789	COG0725	ABC transporter, periplasmic molybdate-binding protein
Theam_0795	COG1215	transferase activity, transferring glycosyl groups
Theam_0800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Theam_0800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Theam_0801	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Theam_0802	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Theam_0807	COG0438	transferase activity, transferring glycosyl groups
Theam_0812	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Theam_0813	COG0179	Fumarylacetoacetate (FAA) hydrolase
Theam_0815	COG0105	UTP biosynthetic process
Theam_0816	COG1515	deoxyribonuclease V activity
Theam_0819	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Theam_0820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Theam_0822	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Theam_0822	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Theam_0823	COG2890	protein-(glutamine-N5) methyltransferase activity
Theam_0824	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Theam_0825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Theam_0826	COG0788	formyltetrahydrofolate deformylase activity
Theam_0827	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Theam_0828	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Theam_0829	COG0739	heme binding
Theam_0829	COG1196	nuclear chromosome segregation
Theam_0829	COG0741	lytic transglycosylase activity
Theam_0831	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
Theam_0832	COG3264	Mechanosensitive ion channel
Theam_0832	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Theam_0834	COG2095	MarC family integral membrane protein
Theam_0835	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Theam_0837	COG1301	dicarboxylic acid transport
Theam_0838	COG0012	GTP binding
Theam_0840	COG1074	ATP-dependent DNA helicase activity
Theam_0842	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Theam_0843	COG0745	RESPONSE REGULATOR receiver
Theam_0844	COG0784	Response regulator, receiver
Theam_0844	COG0835	chemotaxis
Theam_0846	COG0835	chemotaxis
Theam_0847	COG2198	Histidine kinase
Theam_0847	COG0643	Histidine kinase
Theam_0849	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Theam_0850	COG0849	cell division
Theam_0852	COG1181	Belongs to the D-alanine--D-alanine ligase family
Theam_0854	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Theam_0857	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Theam_0858	COG1309	transcriptional regulator
Theam_0860	COG1566	PFAM secretion protein HlyD family protein
Theam_0861	COG2814	Major facilitator Superfamily
Theam_0864	COG1131	(ABC) transporter
Theam_0872	COG1353	crispr-associated protein
Theam_0873	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Theam_0876	COG0315	cyclic pyranopterin monophosphate synthase activity
Theam_0876	COG0521	Mo-molybdopterin cofactor biosynthetic process
Theam_0877	COG0746	molybdenum cofactor guanylyltransferase activity
Theam_0881	COG1136	(ABC) transporter
Theam_0881	COG0577	efflux transmembrane transporter activity
Theam_0882	COG0577	efflux transmembrane transporter activity
Theam_0882	COG1136	(ABC) transporter
Theam_0883	COG1136	(ABC) transporter
Theam_0884	COG0552	protein localization to endoplasmic reticulum
Theam_0885	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Theam_0887	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Theam_0890	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Theam_0893	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Theam_0894	COG0617	tRNA 3'-terminal CCA addition
Theam_0898	COG1459	type II secretion system
Theam_0905	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Theam_0906	COG1110	DNA topoisomerase II activity
Theam_0910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Theam_0912	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Theam_0913	COG0416	fatty acid biosynthetic process
Theam_0914	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Theam_0917	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Theam_0920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Theam_0921	COG4589	Belongs to the CDS family
Theam_0922	COG0309	Hydrogenase expression formation protein (HypE)
Theam_0923	COG0390	transport system, permease component
Theam_0927	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Theam_0929	COG2204	response regulator
Theam_0936	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Theam_0938	COG0019	diaminopimelate decarboxylase activity
Theam_0942	COG0151	Belongs to the GarS family
Theam_0943	COG1196	nuclear chromosome segregation
Theam_0943	COG0741	lytic transglycosylase activity
Theam_0943	COG0739	heme binding
Theam_0944	COG0616	signal peptide processing
Theam_0945	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Theam_0950	COG4974	Belongs to the 'phage' integrase family
Theam_0954	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Theam_0955	COG1335	isochorismatase
Theam_0957	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Theam_0958	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Theam_0959	COG0772	Belongs to the SEDS family
Theam_0962	COG0612	Peptidase, M16
Theam_0969	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Theam_0970	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Theam_0972	COG0574	Belongs to the PEP-utilizing enzyme family
Theam_0972	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Theam_0973	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Theam_0974	COG0166	Belongs to the GPI family
Theam_0975	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Theam_0976	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Theam_0978	COG1449	Belongs to the glycosyl hydrolase 57 family
Theam_0980	COG0297	glycogen (starch) synthase activity
Theam_0982	COG1543	Belongs to the glycosyl hydrolase 57 family
Theam_0983	COG1940	carbohydrate kinase activity
Theam_0984	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Theam_0985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Theam_0988	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Theam_0989	COG1968	undecaprenyl-diphosphatase activity
Theam_0992	COG0156	8-amino-7-oxononanoate synthase activity
Theam_0993	COG4566	intracellular signal transduction
Theam_0994	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Theam_0998	COG0069	glutamate synthase activity
Theam_0998	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Theam_0999	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Theam_1000	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Theam_1001	COG0067	glutamate synthase
Theam_1003	COG0133	tryptophan synthase activity
Theam_1004	COG2200	EAL domain
Theam_1005	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Theam_1006	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Theam_1007	COG4591	ABC-type transport system involved in lipoprotein release permease component
Theam_1008	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Theam_1009	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Theam_1011	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Theam_1012	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Theam_1017	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Theam_1019	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Theam_1020	COG3383	formate dehydrogenase (NAD+) activity
Theam_1021	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Theam_1024	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Theam_1026	COG1690	Belongs to the RtcB family
Theam_1030	COG0517	IMP dehydrogenase activity
Theam_1031	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Theam_1032	COG2252	PERMEase
Theam_1033	COG0501	Belongs to the peptidase M48B family
Theam_1035	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Theam_1036	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Theam_1039	COG0534	Mate efflux family protein
Theam_1040	COG5000	phosphorelay sensor kinase activity
Theam_1041	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Theam_1041	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Theam_1042	COG0242	peptide deformylase activity
Theam_1045	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Theam_1048	COG3706	GGDEF domain
Theam_1049	COG0537	adenosine 5'-monophosphoramidase activity
Theam_1050	COG0768	penicillin binding
Theam_1052	COG2226	methyltransferase
Theam_1053	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
Theam_1055	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theam_1055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theam_1056	COG1881	PFAM PEBP family protein
Theam_1057	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Theam_1060	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Theam_1063	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Theam_1063	COG1796	DNA polymerase
Theam_1066	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Theam_1067	COG1465	3-dehydroquinate synthase
Theam_1070	COG0789	Transcriptional regulator
Theam_1071	COG0542	response to heat
Theam_1075	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Theam_1076	COG1331	Highly conserved protein containing a thioredoxin domain
Theam_1077	COG1509	lysine 2,3-aminomutase activity
Theam_1081	COG0653	protein targeting
Theam_1082	COG0791	NLP P60 protein
Theam_1084	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Theam_1087	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
Theam_1088	COG0277	FAD linked oxidase domain protein
Theam_1092	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Theam_1094	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Theam_1095	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Theam_1101	COG3852	Histidine kinase
Theam_1102	COG2204	response regulator
Theam_1106	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Theam_1107	COG0708	Exodeoxyribonuclease III
Theam_1108	COG0811	peptide transport
Theam_1109	COG2264	protein methyltransferase activity
Theam_1110	COG0739	heme binding
Theam_1110	COG0741	lytic transglycosylase activity
Theam_1110	COG1196	nuclear chromosome segregation
Theam_1111	COG0217	transcriptional regulatory protein
Theam_1112	COG0864	Transcriptional regulator
Theam_1113	COG0084	hydrolase, TatD family'
Theam_1115	COG0018	arginyl-trna synthetase
Theam_1116	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Theam_1121	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
Theam_1122	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
Theam_1124	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Theam_1125	COG0298	carbon dioxide binding
Theam_1126	COG0375	protein maturation
Theam_1127	COG2226	methyltransferase
Theam_1131	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Theam_1132	COG1773	rubredoxin
Theam_1133	COG0426	domain, Protein
Theam_1137	COG0811	peptide transport
Theam_1138	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Theam_1139	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Theam_1140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Theam_1141	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Theam_1142	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Theam_1150	COG0745	RESPONSE REGULATOR receiver
Theam_1154	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Theam_1157	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Theam_1159	COG1516	flagellar protein fliS
Theam_1160	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Theam_1162	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Theam_1163	COG0457	Tetratricopeptide repeat
Theam_1163	COG0463	Glycosyl transferase, family 2
Theam_1166	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Theam_1166	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Theam_1168	COG0180	Tryptophanyl-tRNA synthetase
Theam_1174	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Theam_1176	COG0768	penicillin binding
Theam_1177	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Theam_1178	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Theam_1180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Theam_1182	COG0322	excinuclease ABC activity
Theam_1184	COG0742	ribosomal rna small subunit methyltransferase
Theam_1186	COG0747	negative chemotaxis
Theam_1188	COG0187	DNA topoisomerase II activity
Theam_1189	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Theam_1191	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Theam_1192	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Theam_1194	COG1187	pseudouridine synthase activity
Theam_1197	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Theam_1200	COG1187	pseudouridine synthase activity
Theam_1204	COG0072	phenylalanine-tRNA ligase activity
Theam_1204	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theam_1207	COG1418	mRNA catabolic process
Theam_1211	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Theam_1212	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Theam_1215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Theam_1218	COG0698	ribose 5-phosphate isomerase
Theam_1219	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Theam_1220	COG0668	transmembrane transport
Theam_1221	COG0459	protein refolding
Theam_1222	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Theam_1228	COG0517	IMP dehydrogenase activity
Theam_1228	COG0516	GMP reductase activity
Theam_1229	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Theam_1231	COG0741	lytic transglycosylase activity
Theam_1234	COG0489	protein tyrosine kinase activity
Theam_1238	COG5002	protein histidine kinase activity
Theam_1240	COG2050	protein possibly involved in aromatic compounds catabolism
Theam_1240	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Theam_1242	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Theam_1244	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Theam_1247	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theam_1247	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theam_1249	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
Theam_1250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Theam_1252	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Theam_1253	COG5002	protein histidine kinase activity
Theam_1256	COG0157	Belongs to the NadC ModD family
Theam_1257	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Theam_1258	COG0628	permease
Theam_1259	COG0237	dephospho-CoA kinase activity
Theam_1260	COG1692	metallophosphoesterase
Theam_1261	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Theam_1264	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Theam_1265	COG0318	PFAM AMP-dependent synthetase and ligase
Theam_1266	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Theam_1267	COG1573	uracil-dna glycosylase
Theam_1268	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Theam_1269	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theam_1271	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Theam_1272	COG1053	succinate dehydrogenase
Theam_1273	COG1053	succinate dehydrogenase
Theam_1274	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Theam_1275	COG2048	Heterodisulfide reductase, subunit B
Theam_1278	COG0471	metal ion transport
Theam_1281	COG4399	Belongs to the UPF0754 family
Theam_1282	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Theam_1287	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Theam_1289	COG0463	Glycosyl transferase, family 2
Theam_1290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Theam_1293	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Theam_1296	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theam_1297	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Theam_1298	COG0228	four-way junction DNA binding
Theam_1299	COG1837	Belongs to the UPF0109 family
Theam_1301	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Theam_1303	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theam_1305	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Theam_1308	COG0432	Pfam Uncharacterised protein family UPF0047
Theam_1310	COG1295	ribonuclease BN
Theam_1312	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Theam_1313	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Theam_1316	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Theam_1318	COG2062	phosphohistidine phosphatase, SixA
Theam_1319	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Theam_1321	COG0446	pyridine nucleotide-disulphide oxidoreductase
Theam_1323	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Theam_1324	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Theam_1326	COG2835	tetraacyldisaccharide 4'-kinase activity
Theam_1327	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Theam_1328	COG0540	Belongs to the ATCase OTCase family
Theam_1330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Theam_1333	COG4956	integral membrane protein (PIN domain superfamily)
Theam_1334	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Theam_1335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Theam_1341	COG1489	DNA binding
Theam_1342	COG0588	phosphoglycerate mutase activity
Theam_1343	COG0493	'glutamate synthase
Theam_1344	COG4752	Belongs to the RNA methyltransferase TrmD family
Theam_1345	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Theam_1347	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Theam_1350	COG1131	(ABC) transporter
Theam_1351	COG4968	Prepilin-type N-terminal cleavage methylation domain
Theam_1354	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Theam_1355	COG3118	belongs to the thioredoxin family
Theam_1364	COG0302	gtp cyclohydrolase
Theam_1365	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Theam_1367	COG0037	tRNA processing
Theam_1368	COG0137	argininosuccinate synthase activity
Theam_1369	COG0544	peptidyl-prolyl cis-trans isomerase activity
Theam_1371	COG2205	protein histidine kinase activity
Theam_1372	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Theam_1378	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Theam_1378	COG0674	pyruvate-flavodoxin oxidoreductase activity
Theam_1385	COG4786	Flagellar basal body rod
Theam_1385	COG1256	bacterial-type flagellum assembly
Theam_1389	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Theam_1390	COG1100	Small GTP-binding protein
Theam_1392	COG1013	pyruvate-flavodoxin oxidoreductase activity
Theam_1393	COG0674	pyruvate-flavodoxin oxidoreductase activity
Theam_1394	COG1144	Oxidoreductase
Theam_1395	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Theam_1397	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Theam_1398	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Theam_1401	COG1561	YicC-like family, N-terminal region
Theam_1402	COG0194	GDP metabolic process
Theam_1404	COG0543	2 iron, 2 sulfur cluster binding
Theam_1405	COG0247	lactate metabolic process
Theam_1407	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Theam_1407	COG2199	diguanylate cyclase activity
Theam_1408	COG0045	succinate-CoA ligase (ADP-forming) activity
Theam_1409	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Theam_1411	COG0674	pyruvate-flavodoxin oxidoreductase activity
Theam_1411	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Theam_1412	COG1013	pyruvate-flavodoxin oxidoreductase activity
Theam_1418	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Theam_1421	COG0482	sulfurtransferase activity
Theam_1424	COG0481	GTPase activity
Theam_1429	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Theam_1430	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Theam_1433	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Theam_1437	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Theam_1440	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Theam_1441	COG1684	flagellar biosynthetic protein fliR
Theam_1442	COG1987	bacterial-type flagellum assembly
Theam_1443	COG1338	Plays a role in the flagellum-specific transport system
Theam_1445	COG1580	Controls the rotational direction of flagella during chemotaxis
Theam_1446	COG1749	Flagellar hook protein flgE
Theam_1447	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Theam_1448	COG1157	protein secretion by the type III secretion system
Theam_1450	COG1766	The M ring may be actively involved in energy transduction
Theam_1451	COG1677	Flagellar hook-basal body complex protein FliE
Theam_1452	COG1558	bacterial-type flagellum-dependent cell motility
Theam_1453	COG1815	bacterial-type flagellum-dependent cell motility
Theam_1456	COG1191	sigma factor activity
Theam_1457	COG0455	bacterial-type flagellum organization
Theam_1458	COG1419	protein localization to endoplasmic reticulum
Theam_1459	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Theam_1461	COG1706	bacterial-type flagellum-dependent cell motility
Theam_1462	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
Theam_1464	COG4786	Flagellar basal body rod
Theam_1465	COG4786	Flagellar basal body rod
Theam_1468	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Theam_1470	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Theam_1471	COG0497	DNA recombination
Theam_1472	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Theam_1473	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Theam_1474	COG0492	ferredoxin-NADP+ reductase activity
Theam_1475	COG3118	belongs to the thioredoxin family
Theam_1477	COG1355	regulation of microtubule-based process
Theam_1478	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Theam_1479	COG1260	myo-inositol-1-phosphate synthase
Theam_1483	COG1683	Conserved Protein
Theam_1484	COG0612	Peptidase, M16
Theam_1485	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Theam_1486	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Theam_1488	COG1007	ATP synthesis coupled electron transport
Theam_1489	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_1490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Theam_1492	COG0839	Belongs to the complex I subunit 6 family
Theam_1494	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Theam_1495	COG0649	NAD binding
Theam_1496	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_1496	COG0649	NAD binding
Theam_1497	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theam_1499	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Theam_1501	COG0573	inorganic phosphate transmembrane transporter activity
Theam_1502	COG0587	DNA-directed DNA polymerase activity
Theam_1503	COG0825	malonyl-CoA metabolic process
Theam_1504	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Theam_1505	COG0513	Belongs to the DEAD box helicase family
Theam_1509	COG0585	pseudouridine synthase activity
Theam_1510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Theam_1511	COG2255	four-way junction helicase activity
Theam_1512	COG0632	four-way junction helicase activity
Theam_1517	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Theam_1519	COG3956	TIGRFAM MazG family protein
Theam_1520	COG0215	cysteine-tRNA ligase activity
Theam_1524	COG0310	cobalt ion transport
Theam_1525	COG0310	cobalt ion transport
Theam_1531	COG0285	dihydrofolate synthase activity
Theam_1539	COG0439	Biotin carboxylase
Theam_1540	COG5016	pyruvate
Theam_1540	COG0511	ligase activity, forming carbon-carbon bonds
Theam_1542	COG0606	chelatase, subunit chli
Theam_1544	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Theam_1545	COG0335	large ribosomal subunit rRNA binding
Theam_1546	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Theam_1548	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Theam_1551	COG3300	MHYT domain
Theam_1551	COG5001	Diguanylate cyclase
Theam_1552	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Theam_1554	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Theam_1555	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Theam_1556	COG2521	methyltransferase
Theam_1556	COG2136	Putative SAM-dependent methyltransferase
Theam_1561	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Theam_1566	COG0824	Thioesterase
Theam_1567	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Theam_1569	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Theam_1569	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Theam_1572	COG0585	pseudouridine synthase activity
Theam_1573	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Theam_1575	COG0741	lytic transglycosylase activity
Theam_1575	COG1196	nuclear chromosome segregation
Theam_1575	COG0739	heme binding
Theam_1577	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
Theam_1578	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Theam_1580	COG0222	ribosome binding
Theam_1581	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Theam_1582	COG0081	regulation of translation
Theam_1583	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Theam_1584	COG0250	Participates in transcription elongation, termination and antitermination
Theam_1585	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Theam_1586	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Theam_1587	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Theam_1590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Theam_1591	COG0336	Belongs to the RNA methyltransferase TrmD family
Theam_1595	COG2199	diguanylate cyclase activity
Theam_1595	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
Theam_1596	COG1605	Chorismate mutase
Theam_1596	COG0077	Prephenate dehydratase
Theam_1600	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Theam_1605	COG0356	it plays a direct role in the translocation of protons across the membrane
Theam_1606	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Theam_1608	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Theam_1608	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Theam_1610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theam_1612	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Theam_1619	COG1203	CRISPR-associated helicase, Cas3
Theam_1622	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Theam_1625	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Theam_1627	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Theam_1627	COG0574	Belongs to the PEP-utilizing enzyme family
Theam_1628	COG0751	glycine-tRNA ligase activity
Theam_1629	COG0752	glycyl-tRNA synthetase alpha subunit
Theam_1632	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Theam_1634	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theam_1638	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Theam_1639	COG0726	polysaccharide deacetylase
Theam_1640	COG0463	Glycosyl transferase, family 2
Theam_1641	COG0438	transferase activity, transferring glycosyl groups
Theam_1644	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Theam_1647	COG0154	amidase activity
Theam_1648	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Theam_1651	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Theam_1656	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Theam_1659	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Theam_1660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Theam_1661	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Theam_1662	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Theam_1664	COG0531	amino acid
Theam_1668	COG0445	tRNA wobble uridine modification
Theam_1669	COG0357	Ribosomal RNA small subunit methyltransferase G
Theam_1672	COG0083	homoserine kinase activity
Theam_1676	COG0525	valine-tRNA ligase activity
Theam_1678	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Theam_1682	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Theam_1688	COG0195	Participates in both transcription termination and antitermination
Theam_1689	COG0779	Required for maturation of 30S ribosomal subunits
Theam_1690	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Theam_1691	COG0539	negative regulation of cytoplasmic translation
Theam_1692	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Theam_1694	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Theam_1695	COG0004	ammonium transporteR
Theam_1696	COG0275	rRNA processing
Theam_1697	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Theam_1702	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Theam_1704	COG3339	Conserved Protein
Theam_1712	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Theam_1713	COG1238	metal cluster binding
Theam_1716	COG0750	zinc metalloprotease
Theam_1717	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
Theam_1723	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Theam_1725	COG0134	indole-3-glycerol-phosphate synthase activity
Theam_1726	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Theam_1745	COG3706	GGDEF domain
Theam_1748	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Theam_1762	COG0750	zinc metalloprotease
Theam_1763	COG4974	Belongs to the 'phage' integrase family
Theam_1804	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Theam_1812	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Theam_1825	COG0714	Associated with various cellular activities