locus-tag	class	description
Tlie_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Tlie_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Tlie_0003	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Tlie_0004	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Tlie_0012	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tlie_0014	ENOG4107S6Z	Na H antiporter
Tlie_0015	ENOG4105NCW	Trka-c domain protein
Tlie_0016	ENOG4105CGK	Exodeoxyribonuclease III
Tlie_0026	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_0028	ENOG4105C01	Dihydroxy-acid dehydratase
Tlie_0029	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_0030	ENOG4105XDZ	Tripartite ATP-independent periplasmic transporter
Tlie_0031	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Tlie_0032	ENOG4105JXH	GntR family transcriptional regulator
Tlie_0034	ENOG41081BK	membrane protein-like protein
Tlie_0035	ENOG4105BZU	Histidine kinase
Tlie_0037	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Tlie_0039	ENOG4105E2Z	phosphate ABC transporter (Permease
Tlie_0040	ENOG4105C8U	phosphate abc transporter
Tlie_0041	ENOG4105CVA	phosphate
Tlie_0047	ENOG41090A1	ferritin
Tlie_0048	ENOG4105MAX	Superoxide reductase
Tlie_0049	ENOG4105VCQ	rubredoxin
Tlie_0051	ENOG4105VFE	sira family
Tlie_0053	ENOG4105CZX	twitching motility protein
Tlie_0054	ENOG4108302	MgtC SapB transporter
Tlie_0055	ENOG4105BZU	Histidine kinase
Tlie_0056	ENOG4105DJZ	UPF0182 protein
Tlie_0057	ENOG4107T5V	SNARE associated Golgi
Tlie_0059	ENOG4105EJQ	L-serine dehydratase
Tlie_0062	ENOG4108VAU	general secretion pathway protein G
Tlie_0064	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tlie_0066	ENOG4105CHI	Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity)
Tlie_0068	ENOG410822I	Flagellar hook capping protein
Tlie_0069	ENOG4105BZE	flagellar hook protein, FlgE
Tlie_0070	ENOG4105DTJ	flagellar hook-associated protein
Tlie_0071	ENOG4105D00	flagellar biosynthetic protein flhB
Tlie_0072	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tlie_0074	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
Tlie_0075	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Tlie_0079	ENOG4105E4C	Lytic transglycosylase catalytic
Tlie_0081	ENOG4105D7B	Flagellar biosynthesis protein flha
Tlie_0082	ENOG4106VK6	Flagellar motor protein
Tlie_0084	ENOG4105CBS	Chea signal transduction histidine kinase
Tlie_0086	ENOG4105E14	MotA TolQ exbB proton channel
Tlie_0089	ENOG4105Q75	Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)
Tlie_0090	ENOG4108ZC9	flagellar basal-body rod protein flgc
Tlie_0092	ENOG4105DD5	Flagellar motor switch protein
Tlie_0093	ENOG4105BZU	Histidine kinase
Tlie_0094	ENOG4105FZW	flagellar biosynthesis regulator FlhF
Tlie_0095	ENOG4107R21	site-determining protein
Tlie_0097	ENOG4107YTP	response regulator receiver protein
Tlie_0098	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tlie_0100	ENOG4105CN7	Flagellar biosynthetic protein FliP
Tlie_0102	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
Tlie_0105	ENOG4105D24	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
Tlie_0106	ENOG4105C8Q	Methyl-accepting chemotaxis
Tlie_0107	ENOG4105DTS	flagellar hook-associated
Tlie_0110	ENOG4105E1Q	flagellar hook-associated protein
Tlie_0110	ENOG4105E1Q	flagellar hook-associated protein
Tlie_0112	ENOG4107W7W	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Tlie_0113	ENOG4105D92	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)
Tlie_0118	ENOG4105CMP	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)
Tlie_0122	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tlie_0123	ENOG4108V3W	Chemotaxis protein, CheW
Tlie_0131	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
Tlie_0132	ENOG4105W5T	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)
Tlie_0135	ENOG4105CGA	flagellar basal-body rod protein FlgG
Tlie_0136	ENOG410807Z	Modulation of CheA activity in response to attractants (Chemotaxis
Tlie_0137	ENOG4105C7K	acetolactate synthase
Tlie_0138	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Tlie_0139	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_0140	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_0141	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Tlie_0142	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Tlie_0144	ENOG4105C01	Dihydroxy-acid dehydratase
Tlie_0145	ENOG4105CKY	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)
Tlie_0146	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Tlie_0147	ENOG4108UHF	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Tlie_0148	ENOG4108YZT	Adenosylcobinamide kinase
Tlie_0149	ENOG4105CUP	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)
Tlie_0153	ENOG4105DIK	(ABC) transporter
Tlie_0154	ENOG4107XSR	periplasmic solute binding protein
Tlie_0156	ENOG4107S6Z	Na H antiporter
Tlie_0161	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Tlie_0162	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tlie_0163	ENOG4105JZC	GHMP kinase
Tlie_0164	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Tlie_0165	ENOG4105C8Q	Methyl-accepting chemotaxis
Tlie_0168	ENOG4105DWV	Homoserine O-trans-acetylase
Tlie_0169	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Tlie_0172	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Tlie_0173	ENOG4105DWF	phosphomethylpyrimidine kinase
Tlie_0181	ENOG4105BZU	Histidine kinase
Tlie_0182	ENOG4105DRR	Transcriptional regulator, GntR family
Tlie_0184	ENOG4107SDT	Homocitrate synthase
Tlie_0185	ENOG4105CHM	Aminotransferase
Tlie_0186	ENOG4105C8J	)-transporter
Tlie_0189	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Tlie_0190	ENOG4108HRK	Histidine kinase
Tlie_0191	ENOG4108NEV	two component transcriptional regulator, LytTR family
Tlie_0192	ENOG4105M3W	utilization protein
Tlie_0193	ENOG4105KTW	ethanolamine utilization protein
Tlie_0194	ENOG4105KNY	Microcompartments protein
Tlie_0195	ENOG4105EHR	propanediol utilization protein pduB
Tlie_0197	ENOG4105YCI	dehydratase medium subunit
Tlie_0198	ENOG4108ZFT	Dehydratase small subunit
Tlie_0199	ENOG41084PW	diol glycerol dehydratase reactivating factor large subunit
Tlie_0201	ENOG4105KNY	Microcompartments protein
Tlie_0202	ENOG4105KNY	Microcompartments protein
Tlie_0203	ENOG4108VPX	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)
Tlie_0204	ENOG4107RWI	ethanolamine utilization protein eutJ
Tlie_0207	ENOG4105WVM	ethanolamine utilization protein EutN carboxysome structural protein Ccml
Tlie_0209	ENOG4108EKI	Dehydrogenase
Tlie_0210	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
Tlie_0218	ENOG4105DRR	Transcriptional regulator, GntR family
Tlie_0219	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Tlie_0221	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_0224	ENOG4108RAC	Rubrerythrin
Tlie_0236	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
Tlie_0238	ENOG4105G15	CRISPR-associated RAMP protein, Csm5 family
Tlie_0246	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Tlie_0251	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
Tlie_0254	ENOG4105BZU	Histidine kinase
Tlie_0255	ENOG4105FF2	Type I DHQase
Tlie_0257	ENOG4107S6Z	Na H antiporter
Tlie_0258	ENOG4105DRR	Transcriptional regulator, GntR family
Tlie_0267	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Tlie_0268	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Tlie_0270	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tlie_0271	ENOG4105BZG	amino acid carrier protein
Tlie_0272	ENOG4105WQI	isochorismatase
Tlie_0273	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tlie_0277	ENOG4105CFM	UPF0317 protein
Tlie_0278	ENOG4105E7W	lamb ycsf family protein
Tlie_0280	ENOG4105P4J	Allophanate hydrolase, subunit 1
Tlie_0281	ENOG4105C5A	transporter
Tlie_0282	ENOG4105DTW	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tlie_0283	ENOG4105C1W	two component, sigma54 specific, transcriptional regulator, Fis family
Tlie_0284	ENOG4105BZU	Histidine kinase
Tlie_0286	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tlie_0289	ENOG4107RM6	sulfurtransferase
Tlie_0291	ENOG4105C3R	Methionine synthase
Tlie_0292	ENOG4105SYT	Methylenetetrahydrofolate reductase
Tlie_0296	ENOG4105CKU	formyltetrahydrofolate synthetase
Tlie_0297	ENOG4108Z29	Flavodoxin
Tlie_0298	ENOG4105DZS	Phenylacetate-CoA ligase
Tlie_0300	ENOG4108Z66	YbaK ebsC protein
Tlie_0302	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Tlie_0309	ENOG4105DZ0	fad dependent oxidoreductase
Tlie_0310	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_0312	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Tlie_0314	ENOG4108V0P	LemA family
Tlie_0315	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tlie_0318	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Tlie_0322	ENOG4107RCC	Major Facilitator Superfamily
Tlie_0325	ENOG4108Z7R	Chaperone CsaA
Tlie_0327	ENOG4105PW4	Sugar fermentation stimulation protein homolog
Tlie_0335	ENOG4105EFZ	amidohydrolase
Tlie_0337	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tlie_0338	ENOG4105CK7	Sodium proline symporter
Tlie_0342	ENOG4105D7V	transposase
Tlie_0345	ENOG4105C6X	Major Facilitator
Tlie_0348	ENOG4108JQ7	(ABC) transporter
Tlie_0350	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Tlie_0351	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Tlie_0352	ENOG4108HIY	periplasmic
Tlie_0353	ENOG4105DCG	PHP domain protein
Tlie_0354	ENOG4105W06	Cupin 2, conserved barrel domain protein
Tlie_0355	ENOG4107RCC	Major Facilitator Superfamily
Tlie_0356	ENOG4108DBC	nitroreductase
Tlie_0357	ENOG4105BZU	Histidine kinase
Tlie_0358	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Tlie_0361	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Tlie_0362	ENOG4105BZU	Histidine kinase
Tlie_0366	ENOG4108J9M	Transporter
Tlie_0367	ENOG4105C6T	cysteine synthase
Tlie_0368	ENOG4105D7W	serine acetyltransferase
Tlie_0369	ENOG41088SP	formiminoglutamate hydrolase
Tlie_0370	ENOG4105CGP	Urocanate hydratase
Tlie_0371	ENOG410908R	Methenyltetrahydrofolate cyclohydrolase
Tlie_0372	ENOG4105CI2	imidazolone-5-propionate hydrolase
Tlie_0373	ENOG4105CCS	Glutamate formiminotransferase
Tlie_0374	ENOG4107258	Transcriptional regulator
Tlie_0375	ENOG4105E39	Enoyl-CoA hydratase
Tlie_0383	ENOG4105CHM	Aminotransferase
Tlie_0385	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
Tlie_0387	ENOG4105E66	phosphoriboisomerase A
Tlie_0390	ENOG4107U53	septum site-determining protein minD
Tlie_0391	ENOG4107R7Y	intracellular protease Pfpi family
Tlie_0393	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Tlie_0394	ENOG41071I4	Phosphatidylserine decarboxylase proenzyme
Tlie_0395	ENOG4106PT6	cdpdiacylglycerol-serine O-phosphatidyltransferase
Tlie_0396	ENOG4105N67	Proton-coupled thiamine transporter YuaJ
Tlie_0400	ENOG4105D0C	transport protein
Tlie_0402	ENOG4105D5P	Methylmalonyl-coA mutase
Tlie_0403	ENOG4108ZVT	methylmalonyl-coA epimerase
Tlie_0404	ENOG4107QX3	carboxylase
Tlie_0406	ENOG4105PV1	biotin lipoyl attachment domaiN-containing protein
Tlie_0407	ENOG4105D9Q	decarboxylase (Beta subunit)
Tlie_0408	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Tlie_0410	ENOG4105CEM	UPF0597 protein
Tlie_0414	ENOG4107R4J	Chloride channel
Tlie_0416	ENOG4105D78	K07001 NTE family protein
Tlie_0417	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
Tlie_0419	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Tlie_0422	ENOG4105DB7	PHP domain protein
Tlie_0424	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Tlie_0425	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Tlie_0427	ENOG4105ED0	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)
Tlie_0428	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Tlie_0431	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Tlie_0432	ENOG4108UJD	30S ribosomal protein S9
Tlie_0433	ENOG4105CJW	magnesium transporter
Tlie_0434	ENOG4108IG5	Transcriptional regulator
Tlie_0436	ENOG410624X	efflux transporter, rnd family, mfp subunit
Tlie_0437	ENOG4105BZS	acriflavin resistance protein
Tlie_0442	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tlie_0443	ENOG4105WDJ	50S ribosomal protein L33
Tlie_0444	ENOG410683Z	Preprotein translocase SecE subunit
Tlie_0445	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Tlie_0446	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Tlie_0447	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Tlie_0448	ENOG4108VZM	50s ribosomal protein L10
Tlie_0449	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Tlie_0454	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Tlie_0463	ENOG4105C0D	helicase
Tlie_0475	ENOG4105KJM	monovalent cation h antiporter subunit g
Tlie_0478	ENOG41080EA	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tlie_0479	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Tlie_0480	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Tlie_0482	ENOG4107SI7	Substrate-binding region of abc-type glycine betaine transport system
Tlie_0483	ENOG4107T5X	Binding-protein-dependent transport systems, inner membrane component
Tlie_0484	ENOG4108IJ8	ABC transporter
Tlie_0485	ENOG4105E90	ABC transporter
Tlie_0489	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tlie_0490	ENOG4105DFD	Na H antiporter
Tlie_0494	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Tlie_0495	ENOG4105WH1	Two component transcriptional regulator luxr family
Tlie_0496	ENOG4105CK2	sodium dicarboxylate symporter
Tlie_0498	ENOG4108JZF	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
Tlie_0500	ENOG4105C5R	Aminotransferase
Tlie_0501	ENOG4105DSF	transport protein
Tlie_0502	ENOG4105C5H	ABC transporter
Tlie_0506	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Tlie_0510	ENOG4105HX0	Transcriptional regulator
Tlie_0516	ENOG4105K4P	CoA-binding domain protein
Tlie_0517	ENOG4107QI6	Cysteine desulfurase
Tlie_0518	ENOG4107RIU	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins (By similarity)
Tlie_0525	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
Tlie_0526	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Tlie_0527	ENOG41082RQ	UPF0102 protein
Tlie_0528	ENOG4105C0P	Mg chelatase subunit ChlI
Tlie_0531	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Tlie_0532	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
Tlie_0533	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Tlie_0534	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Tlie_0535	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Tlie_0536	ENOG4105EUM	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)
Tlie_0537	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tlie_0539	ENOG4105C9X	ppx gppa phosphatase
Tlie_0540	ENOG4105CH7	arginosuccinase
Tlie_0542	ENOG4105CVJ	phosphoglycerate mutase
Tlie_0543	ENOG4105DN4	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tlie_0545	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Tlie_0547	ENOG4105D7M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tlie_0548	ENOG4105C7C	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tlie_0550	ENOG4105DAF	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tlie_0554	ENOG4105D0V	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)
Tlie_0556	ENOG4105BZ1	(ABC) transporter
Tlie_0557	ENOG4105CHD	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)
Tlie_0558	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
Tlie_0559	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Tlie_0560	ENOG4105C2X	Arabinose 5-phosphate isomerase
Tlie_0561	ENOG4105D8A	3-Deoxy-D-manno-octulosonic-acid transferase
Tlie_0562	ENOG4105C0A	alcohol dehydrogenase
Tlie_0563	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Tlie_0565	ENOG4105CG5	Glycosyl transferase (Group 1
Tlie_0570	ENOG4107T8Q	Glycosyl transferase (Group 1
Tlie_0579	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Tlie_0580	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Tlie_0581	ENOG41063SB	peptidase
Tlie_0582	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Tlie_0587	ENOG4105CPF	Cell wall formation (By similarity)
Tlie_0588	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Tlie_0589	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Tlie_0590	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Tlie_0591	ENOG4105CFH	Aspartokinase
Tlie_0592	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
Tlie_0594	ENOG4108IUZ	ABC transporter
Tlie_0595	ENOG4108MG9	hydrogenase 3 maturation protease
Tlie_0596	ENOG4105CJR	Integral membrane protein (MviN
Tlie_0599	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tlie_0600	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Tlie_0601	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Tlie_0602	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Tlie_0603	ENOG4105F4G	Membrane
Tlie_0604	ENOG4105FNP	Molybdopterin-guanine dinucleotide biosynthesis protein b
Tlie_0605	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
Tlie_0606	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Tlie_0607	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tlie_0608	ENOG41082I2	s4 domain protein
Tlie_0609	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Tlie_0610	ENOG4105FF6	Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity)
Tlie_0612	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tlie_0613	ENOG4108JIS	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Tlie_0616	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Tlie_0617	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Tlie_0618	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Tlie_0619	ENOG4107VMB	Beta-lactamase domain protein
Tlie_0620	ENOG4105DFF	Rod shape-determining protein mreb
Tlie_0623	ENOG4105CJN	penicillin-binding protein
Tlie_0624	ENOG4107XW6	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Tlie_0626	ENOG41083CN	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Tlie_0627	ENOG4105CNI	cell division protein FtsW
Tlie_0630	ENOG4105C03	ribonuclease
Tlie_0631	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Tlie_0633	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
Tlie_0634	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Tlie_0635	ENOG4105F8V	Hydrolase, tatD family
Tlie_0636	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Tlie_0637	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Tlie_0638	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tlie_0639	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tlie_0640	ENOG4105XPM	ribosomal protein
Tlie_0641	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Tlie_0642	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Tlie_0643	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Tlie_0644	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Tlie_0645	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Tlie_0646	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Tlie_0647	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Tlie_0648	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Tlie_0649	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Tlie_0650	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Tlie_0651	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Tlie_0652	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Tlie_0653	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Tlie_0654	ENOG41082SA	50s ribosomal protein l29
Tlie_0655	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Tlie_0656	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Tlie_0657	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Tlie_0658	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Tlie_0659	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Tlie_0660	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Tlie_0661	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Tlie_0662	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Tlie_0663	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Tlie_0664	ENOG4105VPB	50S ribosomal protein L30
Tlie_0665	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Tlie_0666	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Tlie_0667	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Tlie_0670	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Tlie_0672	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Tlie_0673	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Tlie_0674	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Tlie_0675	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Tlie_0676	ENOG4108ZT0	50S ribosomal protein l17
Tlie_0677	ENOG4108JJB	ABC transporter
Tlie_0678	ENOG4108JJB	ABC transporter
Tlie_0679	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Tlie_0680	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Tlie_0681	ENOG4105DFF	Rod shape-determining protein mreb
Tlie_0684	ENOG4108R0D	protein with myosin-like
Tlie_0687	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Tlie_0688	ENOG4105MJ2	Competence protein
Tlie_0691	ENOG4108IV0	ABC, transporter
Tlie_0692	ENOG4105C0Z	ABC transporter
Tlie_0693	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tlie_0694	ENOG4105C32	Amino acid ABC transporter (Permease)
Tlie_0695	ENOG4105CP9	extracellular ligand-binding receptor
Tlie_0699	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Tlie_0700	ENOG4105F7J	membrane-bound serine protease
Tlie_0701	ENOG4107QX8	SPFH domain, Band 7 family protein
Tlie_0702	ENOG4105C8T	Leucyl-tRNA synthetase
Tlie_0704	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
Tlie_0706	ENOG4105DVT	helicase
Tlie_0710	ENOG4108748	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Tlie_0715	ENOG4107V4F	S-adenosyl-l-methionine hydroxide adenosyltransferase
Tlie_0716	ENOG4105C0H	protease
Tlie_0719	ENOG4105D5G	Transposase
Tlie_0720	ENOG4105GR3	Histidine kinase
Tlie_0722	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Tlie_0723	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Tlie_0724	ENOG4108Z1K	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
Tlie_0726	ENOG4105C8J	)-transporter
Tlie_0727	ENOG4105C22	threonyL-tRNA synthetase
Tlie_0728	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Tlie_0729	ENOG4105VJV	50s ribosomal protein L35
Tlie_0730	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Tlie_0732	ENOG4107ZYR	domain protein
Tlie_0733	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Tlie_0734	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Tlie_0738	ENOG4105C98	muts2 protein
Tlie_0743	ENOG41082DI	50s ribosomal protein l31
Tlie_0745	ENOG4105CBJ	Metal-dependent enzyme
Tlie_0746	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Tlie_0747	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Tlie_0748	ENOG4105C3M	thioredoxin reductase
Tlie_0749	ENOG4105DE4	1-phosphofructokinase
Tlie_0750	ENOG4108UXE	Protein tyrosine phosphatase
Tlie_0751	ENOG4105D0M	Protease HtpX homolog
Tlie_0752	ENOG4105C6E	dna polymerase iii
Tlie_0753	ENOG4105C0B	DNA polymerase III (alpha subunit)
Tlie_0756	ENOG4105P8F	nudix hydrolase
Tlie_0757	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Tlie_0758	ENOG4106M28	alanine racemase domain protein
Tlie_0759	ENOG4105C8B	TIGR00159 family
Tlie_0761	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Tlie_0762	ENOG4105C3Y	UTP-glucose-1-phosphate uridylyltransferase
Tlie_0763	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Tlie_0767	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Tlie_0768	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Tlie_0769	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Tlie_0770	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Tlie_0771	ENOG4108JA2	transcriptioN-repair coupling factor
Tlie_0772	ENOG4105DXN	mazG family
Tlie_0773	ENOG4107QSA	Oxaloacetate decarboxylase
Tlie_0774	ENOG41083MR	nifu domain-containing protein
Tlie_0775	ENOG4105C9A	Phoh family
Tlie_0776	ENOG4105CTJ	Metal Dependent Phosphohydrolase
Tlie_0777	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Tlie_0778	ENOG4108JU6	CBS domain protein
Tlie_0780	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Tlie_0782	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
Tlie_0783	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
Tlie_0784	ENOG4105CF9	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)
Tlie_0785	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Tlie_0786	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Tlie_0787	ENOG4108JQC	penicillin-binding protein 1A
Tlie_0789	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Tlie_0791	ENOG4105VCQ	rubredoxin
Tlie_0794	ENOG4108UI1	Probably functions as a manganese efflux pump (By similarity)
Tlie_0798	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tlie_0800	ENOG4105KXX	peptidase s58 dmpa
Tlie_0801	ENOG4108VB1	regulatoR
Tlie_0802	ENOG4105ENE	Histidine kinase
Tlie_0803	ENOG4108U5N	UPF0316 protein
Tlie_0804	ENOG4105CY0	Metallo-Beta-Lactamase
Tlie_0810	ENOG4105D1S	lipid A biosynthesis
Tlie_0811	ENOG41069HH	4-oxalocrotonate tautomerase
Tlie_0813	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tlie_0816	ENOG4108JQ1	Dehydrogenase
Tlie_0818	ENOG4105E3H	phosphoglycerate mutase
Tlie_0820	ENOG4105EI2	Pseudouridine synthase
Tlie_0822	ENOG4105D82	Glutamate dehydrogenase
Tlie_0823	ENOG4105CH2	amidohydrolase
Tlie_0824	ENOG4105CEY	Amp-dependent synthetase and ligase
Tlie_0825	ENOG4105DW0	Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)
Tlie_0826	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
Tlie_0829	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Tlie_0830	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Tlie_0831	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Tlie_0832	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Tlie_0833	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Tlie_0834	ENOG4105E21	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Tlie_0835	ENOG4108IQ6	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Tlie_0836	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Tlie_0837	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tlie_0841	ENOG4108WYP	Transcriptional regulator
Tlie_0848	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
Tlie_0849	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Tlie_0850	ENOG4108ZAI	phosphatidylglycerophosphatase a
Tlie_0851	ENOG4107TH8	cina domain protein
Tlie_0852	ENOG4105M7V	2'-5' rna ligase
Tlie_0853	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Tlie_0855	ENOG4105CZX	twitching motility protein
Tlie_0856	ENOG4105D7Q	type ii secretion system
Tlie_0857	ENOG4108VAU	general secretion pathway protein G
Tlie_0862	ENOG4105E4G	Type IV pilus
Tlie_0863	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Tlie_0867	ENOG4105M7K	Involved in the transcription termination process (By similarity)
Tlie_0868	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tlie_0869	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Tlie_0870	ENOG4105C3E	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)
Tlie_0871	ENOG4105D6T	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity)
Tlie_0872	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tlie_0873	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Tlie_0874	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Tlie_0875	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Tlie_0876	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Tlie_0877	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Tlie_0878	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Tlie_0879	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Tlie_0880	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Tlie_0886	ENOG4108YZ4	nudix hydrolase
Tlie_0889	ENOG4105CMW	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)
Tlie_0890	ENOG4105DAV	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Tlie_0893	ENOG4108JQ9	ABC transporter
Tlie_0894	ENOG4105UIB	(ABC) transporter
Tlie_0896	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
Tlie_0897	ENOG4105C8N	cysteinyl-tRNA synthetase
Tlie_0898	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Tlie_0899	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Tlie_0900	ENOG4108R6K	riboflavin synthase, subunit alpha
Tlie_0901	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Tlie_0902	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Tlie_0903	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Tlie_0905	ENOG41080XP	Cbs domain
Tlie_0912	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Tlie_0913	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Tlie_0916	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Tlie_0917	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Tlie_0918	ENOG4105CTP	PilT protein domain protein
Tlie_0919	ENOG4108EM8	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) (By similarity)
Tlie_0920	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tlie_0921	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
Tlie_0922	ENOG4105CHV	Transcription elongation factor NusA
Tlie_0923	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
Tlie_0924	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Tlie_0927	ENOG4105SFS	phosphoesterase RecJ domain protein
Tlie_0928	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Tlie_0929	ENOG4105DTN	riboflavin biosynthesis protein ribF
Tlie_0930	ENOG4108KE4	O-methyltransferase
Tlie_0933	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Tlie_0935	ENOG4105C34	Pseudouridine synthase
Tlie_0936	ENOG4105F23	Fibronectin-binding protein
Tlie_0941	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Tlie_0942	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Tlie_0943	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Tlie_0946	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Tlie_0947	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Tlie_0948	ENOG4105K8N	protein family UPF0079, ATPase
Tlie_0949	ENOG41072GX	Peptidase M22 Glycoprotease
Tlie_0953	ENOG4107KMQ	bfd domain protein (2fe-2s)-binding domain protein
Tlie_0956	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Tlie_0957	ENOG4105DQU	oxidoreductase, subunit beta
Tlie_0959	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Tlie_0963	ENOG4105QD4	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tlie_0966	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Tlie_0968	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tlie_0969	ENOG4108V6E	Cell division protein mraZ
Tlie_0970	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Tlie_0972	ENOG4105CJN	penicillin-binding protein
Tlie_0973	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Tlie_0974	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
Tlie_0975	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Tlie_0976	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Tlie_0977	ENOG4105CNI	cell division protein FtsW
Tlie_0978	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Tlie_0979	ENOG4105DFU	Cell wall formation (By similarity)
Tlie_0980	ENOG4105D4A	Cell wall formation (By similarity)
Tlie_0982	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Tlie_0983	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
Tlie_0984	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tlie_0986	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Tlie_0987	ENOG4105HD0	Transcriptional regulator of molybdate metabolism, LysR family
Tlie_0988	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tlie_0989	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tlie_0990	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Tlie_0992	ENOG4105CHW	UPF0052 protein
Tlie_0993	ENOG4105CIE	May be required for sporulation (By similarity)
Tlie_0996	ENOG4105BZA	Phosphoglycerate kinase
Tlie_0997	ENOG4105CP7	Triose-phosphate isomerase
Tlie_0998	ENOG4105HDK	L-asparaginase
Tlie_1001	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Tlie_1002	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Tlie_1003	ENOG4105K46	50S ribosomal protein l27
Tlie_1007	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Tlie_1008	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
Tlie_1009	ENOG4105DX0	Hemolysin A
Tlie_1010	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Tlie_1011	ENOG4105CTB	Polyprenyl synthetase
Tlie_1012	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
Tlie_1013	ENOG4105VB9	50S ribosomal protein l28
Tlie_1015	ENOG4105CNU	cell division protein FtsK
Tlie_1016	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Tlie_1017	ENOG4105HHA	aminodeoxychorismate lyase
Tlie_1019	ENOG4108IV0	ABC, transporter
Tlie_1020	ENOG4105C0Z	ABC transporter
Tlie_1022	ENOG4105C32	Amino acid ABC transporter (Permease)
Tlie_1023	ENOG4105C84	Histidine ammonia-lyase
Tlie_1025	ENOG4105NBF	ammecr1 domain protein
Tlie_1026	ENOG4105NBF	ammecr1 domain protein
Tlie_1028	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Tlie_1029	ENOG4105JFG	SpoIID LytB domain protein
Tlie_1030	ENOG41061AI	Protein of unknown function (DUF2905)
Tlie_1031	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Tlie_1032	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Tlie_1033	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Tlie_1034	ENOG4105CDY	transcriptional regulatory protein
Tlie_1035	ENOG4107RA1	nh(3)-dependent nad( ) synthetase
Tlie_1039	ENOG4105MRR	Transcriptional regulator (By similarity)
Tlie_1041	ENOG4105DBV	ornithine carbamoyltransferase
Tlie_1042	ENOG4105CEU	Arginine dihydrolase
Tlie_1043	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Tlie_1044	ENOG4105CYW	agmatinase
Tlie_1045	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Tlie_1047	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Tlie_1048	ENOG4105DZP	Membrane-associated zinc metalloprotease
Tlie_1049	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Tlie_1050	ENOG4105KNE	Phosphatidate cytidylyltransferase
Tlie_1051	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Tlie_1052	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Tlie_1054	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tlie_1055	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Tlie_1057	ENOG4105ESV	Glycosyl transferase, family 4
Tlie_1058	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Tlie_1063	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Tlie_1064	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Tlie_1065	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
Tlie_1066	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Tlie_1067	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Tlie_1068	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Tlie_1069	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Tlie_1070	ENOG4105KGF	protein, YerC YecD
Tlie_1072	ENOG4105CSM	endonuclease III
Tlie_1073	ENOG4105DAN	ATP-dependent protease
Tlie_1074	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Tlie_1075	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Tlie_1078	ENOG4105C83	adenylosuccinate lyase
Tlie_1080	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Tlie_1081	ENOG4105MA4	psp1 domain protein
Tlie_1083	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Tlie_1085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tlie_1086	ENOG4105CY3	ABC transporter, permease
Tlie_1089	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Tlie_1091	ENOG4107XPQ	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Tlie_1093	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
Tlie_1094	ENOG4105DF0	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity)
Tlie_1095	ENOG4105CD3	dihydroorotase
Tlie_1096	ENOG4105CXT	aspartate transcarbamylase
Tlie_1097	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
Tlie_1098	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
Tlie_1100	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Tlie_1101	ENOG4105CHR	reductase
Tlie_1102	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Tlie_1103	ENOG4105EA8	2-Nitropropane dioxygenase
Tlie_1104	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Tlie_1105	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Tlie_1106	ENOG4108VVV	Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity)
Tlie_1107	ENOG41067VY	50S ribosomal protein L32
Tlie_1109	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
Tlie_1110	ENOG4105CDE	UPF0348 protein
Tlie_1111	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Tlie_1112	ENOG4106H78	methyltransferase
Tlie_1113	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Tlie_1114	ENOG4105EJ5	oxidoreductase gamma subunit
Tlie_1115	ENOG4105WGB	oxidoreductase, delta subunit
Tlie_1116	ENOG4105D95	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity)
Tlie_1117	ENOG4105DDK	oxidoreductase, beta subunit
Tlie_1118	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Tlie_1120	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Tlie_1122	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Tlie_1124	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Tlie_1125	ENOG4105KC4	UPF0296 protein
Tlie_1126	ENOG4105DSJ	YicC domain protein
Tlie_1127	ENOG4107RIS	Acyl-transferase
Tlie_1128	ENOG4105CAT	Cytidine monophosphate kinase
Tlie_1129	ENOG4105FE9	pseudouridine synthase
Tlie_1130	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Tlie_1132	ENOG4105C31	Tryptophanyl-tRNA synthetase
Tlie_1133	ENOG4105EGD	dinuclear metal center protein, YbgI family
Tlie_1134	ENOG41084T3	4fe-4S ferredoxin iron-sulfur binding domain-containing protein
Tlie_1135	ENOG4105DFT	pur operon repressor
Tlie_1136	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Tlie_1138	ENOG4105EM7	Selenocysteine-specific translation elongation factor
Tlie_1139	ENOG4105C1Y	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)
Tlie_1142	ENOG4105CSA	Coproporphyrinogen iii oxidase
Tlie_1143	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Tlie_1144	ENOG4105C8V	SAICAR synthetase
Tlie_1146	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Tlie_1147	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Tlie_1149	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Tlie_1150	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Tlie_1151	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Tlie_1152	ENOG4107QNG	Phosphoribosylglycinamide synthetase
Tlie_1159	ENOG4105D6E	homoserine dehydrogenase
Tlie_1160	ENOG4105C9B	Cysteine desulfurase
Tlie_1163	ENOG4105C5I	Dehydrogenase
Tlie_1164	ENOG4105C28	cystathionine
Tlie_1166	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Tlie_1167	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Tlie_1168	ENOG4105CDH	Citrulline--aspartate ligase
Tlie_1170	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Tlie_1171	ENOG4108Z4T	Peptidase M50
Tlie_1172	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Tlie_1173	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Tlie_1177	ENOG4108J2R	molybdopterin oxidoreductase
Tlie_1178	ENOG4105MS2	ribosomal subunit Interface protein
Tlie_1179	ENOG4105CHM	Aminotransferase
Tlie_1180	ENOG4105C5B	carbamate kinase
Tlie_1181	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Tlie_1182	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Tlie_1183	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Tlie_1184	ENOG4105CE9	30S ribosomal protein S2
Tlie_1185	ENOG4105VPX	protein, conserved in bacteria
Tlie_1187	ENOG4108Z6B	deaminase
Tlie_1192	ENOG4105CYT	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
Tlie_1194	ENOG4108IXP	Carbohydrate diacid transcriptional activator CdaR
Tlie_1197	ENOG4105C2M	dna polymerase I
Tlie_1198	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Tlie_1200	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Tlie_1201	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tlie_1202	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Tlie_1203	ENOG4105C47	NADH ubiquinone oxidoreductase 20 kda subunit
Tlie_1205	ENOG4108JPZ	Monovalent cation H antiporter subunit D
Tlie_1206	ENOG4108ZE9	Monovalent cation H antiporter subunit C
Tlie_1208	ENOG4105D65	subunit l
Tlie_1212	ENOG4105SC1	monovalent cation H antiporter subunit E
Tlie_1216	ENOG4105CH2	amidohydrolase
Tlie_1217	ENOG4105E1V	na solute symporter
Tlie_1219	ENOG4105D7N	magnesium and cobalt transport protein CorA
Tlie_1222	ENOG4105CPF	Cell wall formation (By similarity)
Tlie_1225	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Tlie_1226	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tlie_1231	ENOG4105C6K	Malic enzyme
Tlie_1232	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Tlie_1235	ENOG4108ZI0	d,d-heptose 1,7-bisphosphate phosphatase
Tlie_1236	ENOG4105C1B	dTDP-glucose 4-6-dehydratase
Tlie_1238	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Tlie_1240	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Tlie_1241	ENOG4105DIW	FeS assembly protein SUFB
Tlie_1242	ENOG4108IUZ	ABC transporter
Tlie_1243	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Tlie_1244	ENOG4108IAA	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Tlie_1245	ENOG4107QYV	phosphohexose isomerase
Tlie_1248	ENOG4107QIZ	NADH dehydrogenase
Tlie_1249	ENOG4108JB9	formate dehydrogenase
Tlie_1250	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Tlie_1251	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tlie_1252	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Tlie_1253	ENOG41081AP	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Tlie_1254	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Tlie_1255	ENOG4105CRK	lysyL-tRNA synthetase
Tlie_1256	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Tlie_1257	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Tlie_1260	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tlie_1262	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Tlie_1267	ENOG4107QMH	DNA methylase
Tlie_1269	ENOG4105C0D	helicase
Tlie_1271	ENOG4105CMR	udp-glucose 4-epimerase
Tlie_1272	ENOG4105DC7	peptidase M24
Tlie_1274	ENOG4105WPN	DNA integration recombination invertion protein
Tlie_1276	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tlie_1277	ENOG41067XB	TonB family
Tlie_1278	ENOG4105M8F	Biopolymer transport protein exbD tolR
Tlie_1279	ENOG4105JKQ	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity)
Tlie_1282	ENOG4105DCF	alanine dehydrogenase
Tlie_1283	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
Tlie_1284	ENOG4105BZG	amino acid carrier protein
Tlie_1288	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
Tlie_1289	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
Tlie_1290	ENOG4105EZ5	reductase
Tlie_1294	ENOG4105C8J	)-transporter
Tlie_1295	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Tlie_1297	ENOG4105CQS	hydrogenase expression formation protein HypD
Tlie_1298	ENOG4105C45	hydrogenase expression formation protein (HypE)
Tlie_1299	ENOG4105D48	metallophosphoesterase
Tlie_1300	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Tlie_1302	ENOG4105CB5	ATP-dependent DNA helicase recG
Tlie_1303	ENOG4105MMF	Cell division protein DIVIVA
Tlie_1304	ENOG4105DFA	alanine racemase domain protein
Tlie_1307	ENOG4105DZA	Converts GTP to 7,8-dihydroneopterin triphosphate (By similarity)
Tlie_1308	ENOG4107ZIF	6-carboxy-5,6,7,8-tetrahydropterin synthase
Tlie_1310	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Tlie_1313	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tlie_1314	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Tlie_1316	ENOG4105H9W	Short-chain dehydrogenase reductase Sdr
Tlie_1320	ENOG4105CDU	Replicative dna helicase
Tlie_1321	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Tlie_1323	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Tlie_1324	ENOG4108UUM	single-stranded DNA-binding protein
Tlie_1325	ENOG410829C	Binds together with S18 to 16S ribosomal RNA (By similarity)
Tlie_1327	ENOG4105C75	arginyL-tRNA synthetase
Tlie_1329	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Tlie_1330	ENOG4105C0F	tryptophanase EC 4.1.99.1
Tlie_1331	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Tlie_1332	ENOG4108IV0	ABC, transporter
Tlie_1333	ENOG4105C0Z	ABC transporter
Tlie_1334	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Tlie_1335	ENOG4105C32	Amino acid ABC transporter (Permease)
Tlie_1338	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Tlie_1341	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Tlie_1342	ENOG4105KTH	gatB Yqey
Tlie_1343	ENOG4105VCC	30S ribosomal protein S21
Tlie_1344	ENOG4107YU2	histidine triad (hIT) protein
Tlie_1345	ENOG4108JVH	Protein of unknown function DUF43
Tlie_1346	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Tlie_1348	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Tlie_1349	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Tlie_1350	ENOG4105CFG	Acts as a chaperone (By similarity)
Tlie_1351	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Tlie_1352	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Tlie_1357	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Tlie_1360	ENOG4105C59	p-type ATPase
Tlie_1364	ENOG4105D22	carbon starvation protein
Tlie_1366	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Tlie_1367	ENOG4105PXI	polysaccharide deacetylase
Tlie_1368	ENOG4105CN1	protease
Tlie_1369	ENOG41063SB	peptidase
Tlie_1370	ENOG4105CRP	Part of the ABC transporter FtsEX involved in
Tlie_1371	ENOG4105CAK	Cell division ATP-binding protein ftsE
Tlie_1372	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Tlie_1376	ENOG4108Z03	MAF-like protein
Tlie_1378	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Tlie_1383	ENOG4105E0Y	RtcB Protein
Tlie_1384	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Tlie_1389	ENOG4105DFD	Na H antiporter
Tlie_1394	ENOG4108Z3G	3H domain protein
Tlie_1396	ENOG4108IA2	Sodium pantothenate symporter
Tlie_1397	ENOG4107W7X	Aldolase
Tlie_1398	ENOG4105JAB	phenazine biosynthesis protein, phzf family
Tlie_1399	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Tlie_1401	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tlie_1402	ENOG41066A3	ATP guanido phosphotransferase
Tlie_1403	ENOG4108Z0C	Uvrb UvrC protein
Tlie_1404	ENOG4105KEX	transcriptional regulator, ctsr
Tlie_1405	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Tlie_1406	ENOG4105CD5	CoA-binding domain protein
Tlie_1407	ENOG4105C0A	alcohol dehydrogenase
Tlie_1408	ENOG4108PXI	ErfK YbiS YcfS YnhG
Tlie_1410	ENOG4105DPN	Oligoendopeptidase f
Tlie_1417	ENOG4105DR9	pseudouridine synthase
Tlie_1420	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Tlie_1421	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Tlie_1422	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Tlie_1423	ENOG4105VB6	UPF0109 protein
Tlie_1424	ENOG4105K5M	30s ribosomal protein S16
Tlie_1429	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Tlie_1430	ENOG4105C1A	potassium transporter peripheral membrane
Tlie_1432	ENOG4105EJ9	Membrane
Tlie_1436	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
Tlie_1437	ENOG41067QW	Transcriptional regulator
Tlie_1441	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Tlie_1443	ENOG4105C9M	aspartyl-trna synthetase
Tlie_1444	ENOG4105CUT	histidyl-tRNA synthetase
Tlie_1445	ENOG4105MCT	stage V sporulation protein S
Tlie_1446	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tlie_1447	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Tlie_1449	ENOG41081QJ	UBA THIF-type NAD FAD binding
Tlie_1451	ENOG4105CX6	glutaminyL-tRNA synthetase
Tlie_1454	ENOG4105II7	pyrroline-5-carboxylate reductase
Tlie_1456	ENOG4105C94	Transporter
Tlie_1460	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
Tlie_1461	ENOG4105Q1T	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination
Tlie_1462	ENOG4105WH1	Two component transcriptional regulator luxr family
Tlie_1464	ENOG4108JB9	formate dehydrogenase
Tlie_1465	ENOG4107QIZ	NADH dehydrogenase
Tlie_1469	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Tlie_1470	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Tlie_1471	ENOG4105CAS	nag kinase
Tlie_1472	ENOG4105C8Y	Acetylornithine aminotransferase
Tlie_1473	ENOG4108KB0	deacetylase
Tlie_1477	ENOG4108IUS	Transketolase
Tlie_1478	ENOG4108HHA	Transketolase
Tlie_1479	ENOG4105D9Q	decarboxylase (Beta subunit)
Tlie_1480	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Tlie_1482	ENOG4108R96	Methyltransferase, YaeB family
Tlie_1483	ENOG4105WMR	Protein CrcB homolog
Tlie_1484	ENOG4105KJJ	Uncharacterized ACR, COG1993
Tlie_1485	ENOG4105E0F	Histidine kinase
Tlie_1486	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
Tlie_1489	ENOG4105C1J	atp-dependent rna helicase
Tlie_1491	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Tlie_1492	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Tlie_1499	ENOG4106C6A	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Tlie_1500	ENOG4107YCY	Transcriptional regulator
Tlie_1505	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
Tlie_1506	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Tlie_1507	ENOG4105C28	cystathionine
Tlie_1509	ENOG4108V1J	Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity)
Tlie_1510	ENOG410841Q	phosphoesterase PA-phosphatase related protein
Tlie_1512	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Tlie_1515	ENOG4108WBT	adenosyltransferase
Tlie_1516	ENOG41073TP	transcriptional regulator
Tlie_1525	ENOG4105EHH	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)
Tlie_1528	ENOG4108JYZ	YitT family
Tlie_1531	ENOG4105C3G	gtp-binding protein
Tlie_1534	ENOG4105I3K	Ferric uptake regulator, Fur family
Tlie_1538	ENOG4107QMS	site-determining protein
Tlie_1540	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_1541	ENOG4108K1J	Transporter DctQ
Tlie_1542	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
Tlie_1546	ENOG4105CE1	Ferrous iron transport protein b
Tlie_1547	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Tlie_1548	ENOG4105EHG	Permease protein
Tlie_1549	ENOG4105CVJ	phosphoglycerate mutase
Tlie_1551	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Tlie_1552	ENOG4105D6E	homoserine dehydrogenase
Tlie_1553	ENOG4105ETE	Transcriptional regulator (LacI family
Tlie_1555	ENOG4105KHC	sulfurtransferase
Tlie_1556	ENOG4107U14	binding-protein-dependent transport systems inner membrane Component
Tlie_1557	ENOG4108IJ7	Glycine betaine
Tlie_1560	ENOG41073TP	transcriptional regulator
Tlie_1562	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_1563	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_1564	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_1565	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_1566	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Tlie_1569	ENOG4105CHY	citrate lyase, alpha
Tlie_1570	ENOG4108I5C	dEAD DEAH box helicase
Tlie_1571	ENOG4107X2U	Inherit from COG: Exonuclease-like protein
Tlie_1573	ENOG4108IAJ	Nad-dependent epimerase dehydratase
Tlie_1574	ENOG4105C6N	Formate acetyltransferase
Tlie_1575	ENOG4105F1A	Pyruvate formate-lyase
Tlie_1577	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_1579	ENOG4108ERU	trap dicarboxylate transporter subunit DctP
Tlie_1580	ENOG4105EJQ	L-serine dehydratase
Tlie_1583	ENOG4105CTU	Proline racemase
Tlie_1590	ENOG4105CQB	FAD linked oxidase domain protein
Tlie_1591	ENOG4105C10	Electron transfer flavoprotein
Tlie_1592	ENOG4105BZJ	Electron transfer flavoprotein
Tlie_1593	ENOG4105CI3	gtp-binding protein typa
Tlie_1594	ENOG4105FSR	swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria
Tlie_1599	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Tlie_1601	ENOG4105CFG	Acts as a chaperone (By similarity)
Tlie_1603	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
Tlie_1606	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
Tlie_1607	ENOG4105CRW	Short chain fatty acid transporter
Tlie_1610	ENOG41084UG	Pfam:DUF1458
Tlie_1612	ENOG41066UG	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity)
Tlie_1617	ENOG4108HIZ	formate dehydrogenase alpha subunit
Tlie_1618	ENOG4107QIZ	NADH dehydrogenase
Tlie_1622	ENOG4105C6R	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Tlie_1623	ENOG4105TMB	Formate nitrite transporter
Tlie_1624	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
Tlie_1631	ENOG4108ZJ4	polysaccharide deacetylase
Tlie_1632	ENOG4105D78	K07001 NTE family protein
Tlie_1634	ENOG4105EJ7	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity)
Tlie_1635	ENOG410847I	Transcriptional regulator, BadM Rrf2 family
Tlie_1636	ENOG4105DFG	type I secretion outer membrane protein
Tlie_1637	ENOG4105DJY	efflux transporter, rnd family, mfp subunit
Tlie_1638	ENOG4108EE5	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tlie_1639	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Tlie_1643	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
Tlie_1644	ENOG4108JJB	ABC transporter
Tlie_1646	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tlie_1649	ENOG4108N5B	2-phosphosulfolactate phosphatase
Tlie_1654	ENOG4107QRT	dEAD DEAH box helicase
Tlie_1655	ENOG4105EXW	epimerase dehydratase
Tlie_1656	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Tlie_1659	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
Tlie_1660	ENOG4105CHM	Aminotransferase
Tlie_1661	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Tlie_1663	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Tlie_1666	ENOG4108V1U	phospholipid-binding protein
Tlie_1667	ENOG4105EPD	Oligopeptide transporter, Opt family
Tlie_1669	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tlie_1670	ENOG4105K70	DNA-binding protein
Tlie_1671	ENOG4105C6T	cysteine synthase
Tlie_1672	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
Tlie_1673	ENOG4105DRR	Transcriptional regulator, GntR family
Tlie_1677	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_1678	ENOG4108HMX	isocitrate dehydrogenase (NADP)
Tlie_1679	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
Tlie_1681	ENOG4105CHY	citrate lyase, alpha
Tlie_1682	ENOG4105VEQ	Cold shock protein
Tlie_1684	ENOG4105DHT	Metal Dependent Phosphohydrolase
Tlie_1685	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Tlie_1686	ENOG4105KME	endoribonuclease L-psp
Tlie_1693	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Tlie_1694	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_1697	ENOG4105Z5Q	
Tlie_1699	ENOG4108JPW	Aminotransferase
Tlie_1700	ENOG4108S3I	UPF0259 membrane protein
Tlie_1701	ENOG4105CKM	Branched-chain carboxylic acid kinase
Tlie_1702	ENOG4107RE7	phosphate butyryltransferase
Tlie_1703	ENOG4107RE7	phosphate butyryltransferase
Tlie_1704	ENOG4105CKM	Branched-chain carboxylic acid kinase
Tlie_1705	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Tlie_1712	ENOG4105CIF	Ornithine Cyclodeaminase
Tlie_1714	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
Tlie_1715	ENOG4108MRH	transcriptional regulatory protein
Tlie_1718	ENOG4105C7K	acetolactate synthase
Tlie_1721	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Tlie_1725	ENOG4108JQ9	ABC transporter
Tlie_1726	ENOG4107TFB	basic membrane
Tlie_1727	ENOG4105DBV	ornithine carbamoyltransferase
Tlie_1728	ENOG4107S4Y	M20 DapE family protein YgeY
Tlie_1729	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Tlie_1731	ENOG4105DR6	Trap dicarboxylate transporter, dctp subunit
Tlie_1733	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Tlie_1734	ENOG4107R5I	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
Tlie_1735	ENOG4107S4Y	M20 DapE family protein YgeY
Tlie_1736	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Tlie_1738	ENOG4105C8W	ABC transporter
Tlie_1739	ENOG4107A5B	Binding-protein-dependent transport systems, inner membrane component
Tlie_1740	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Tlie_1741	ENOG4105CH2	amidohydrolase
Tlie_1742	ENOG4105CH2	amidohydrolase
Tlie_1743	ENOG4105CFC	Transporter
Tlie_1748	ENOG4105K95	(LipO)protein
Tlie_1750	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
Tlie_1751	ENOG4105EHG	Permease protein
Tlie_1753	ENOG4105BZU	Histidine kinase
Tlie_1755	ENOG4105DQU	oxidoreductase, subunit beta
Tlie_1756	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Tlie_1762	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Tlie_1767	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Tlie_1776	ENOG4108UXE	Protein tyrosine phosphatase
Tlie_1778	ENOG41068KF	Universal stress protein
Tlie_1782	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
Tlie_1792	ENOG4105C7K	acetolactate synthase
Tlie_1793	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Tlie_1794	ENOG4108IJ8	ABC transporter
Tlie_1798	ENOG4107QKW	extracellular solute-binding protein family 1
Tlie_1799	ENOG4107QVT	Binding-protein-dependent transport systems, inner membrane component
Tlie_1801	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Tlie_1802	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Tlie_1809	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
Tlie_1811	ENOG4105D3Q	Sugar transferase
Tlie_1813	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Tlie_1821	ENOG4108UW5	maltose o-acetyltransferase
Tlie_1825	ENOG4105J5G	Transferase hexapeptide repeat containing protein
Tlie_1826	ENOG4107QQG	Dehydrogenase
Tlie_1828	ENOG4105CJR	Integral membrane protein (MviN
Tlie_1833	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_1834	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Tlie_1835	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
Tlie_1838	ENOG4105CQC	Prephenate dehydratase
Tlie_1839	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Tlie_1840	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Tlie_1841	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Tlie_1842	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Tlie_1844	ENOG4105DDQ	anthranilate synthase
Tlie_1845	ENOG4105CRQ	synthase (Component I)
Tlie_1846	ENOG4107WTJ	Methyl-accepting chemotaxis sensory transducer
Tlie_1849	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Tlie_1850	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Tlie_1851	ENOG4105IQJ	Involved in biosynthesis of the thiamine precursor thiazole (By similarity)
Tlie_1852	ENOG4105DFD	Na H antiporter
Tlie_1854	ENOG4105BZU	Histidine kinase
Tlie_1855	ENOG4105BZU	Histidine kinase
Tlie_1859	ENOG4105C6K	Malic enzyme
Tlie_1860	ENOG4105C8M	UPF0272 protein
Tlie_1861	ENOG4105DTC	1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (air) carboxylase
Tlie_1863	ENOG4105QUH	Domain of unknown function (DUF2088)
Tlie_1865	ENOG4105C6F	GntR Family Transcriptional Regulator
Tlie_1868	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Tlie_1869	ENOG4105FDR	Membrane
Tlie_1871	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
Tlie_1872	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
Tlie_1875	ENOG4105FA0	parb-like partition protein
Tlie_1876	ENOG4107QJE	Chromosome Partitioning Protein
Tlie_1877	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Tlie_1881	ENOG4105C7B	Threonine dehydratase
Tlie_1882	ENOG410667J	hydrolase
Tlie_1883	ENOG4105C9B	Cysteine desulfurase
Tlie_1884	ENOG4105HEE	Binding Domain protein
Tlie_1889	ENOG4105C26	Dehydrogenase
Tlie_1890	ENOG4105D0C	transport protein
Tlie_1893	ENOG4105CYC	Transferase
Tlie_1894	ENOG4105D49	3-dehydroquinate synthase
Tlie_1895	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Tlie_1896	ENOG4105E2X	shikimate dehydrogenase
Tlie_1899	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
Tlie_1902	ENOG4108RAC	Rubrerythrin
Tlie_1905	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Tlie_1910	ENOG4105C8Y	Acetylornithine aminotransferase
Tlie_1911	ENOG4108KK1	membrane protein AbrB duplication
Tlie_1914	ENOG4105WE2	aldehyde ferredoxin oxidoreductase