locus-tag	class	description
KNN15_00015	COG2084	Dehydrogenase
KNN15_00030	COG0765	amino acid transport
KNN15_00035	COG4597	amino acid ABC transporter
KNN15_00040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNN15_00045	COG0675	Transposase, IS605 OrfB family
KNN15_00075	COG0582	viral genome integration into host DNA
KNN15_00085	COG0052	Belongs to the universal ribosomal protein uS2 family
KNN15_00090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
KNN15_00095	COG0528	UMP kinase activity
KNN15_00100	COG0233	cytoplasmic translational termination
KNN15_00105	COG4589	Belongs to the CDS family
KNN15_00110	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
KNN15_00115	COG0750	zinc metalloprotease
KNN15_00130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KNN15_00135	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KNN15_00140	COG2359	stage V sporulation protein S
KNN15_00150	COG2137	regulation of response to DNA damage stimulus
KNN15_00170	COG2766	serine protein kinase
KNN15_00180	COG2719	SpoVR family
KNN15_00185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNN15_00190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KNN15_00205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KNN15_00220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KNN15_00225	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
KNN15_00230	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
KNN15_00235	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
KNN15_00245	COG3706	GGDEF domain
KNN15_00265	COG2151	metal-sulfur cluster biosynthetic enzyme
KNN15_00305	COG2181	nitrate reductase activity
KNN15_00320	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KNN15_00335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNN15_00340	COG1252	NADH dehydrogenase
KNN15_00360	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KNN15_00370	COG0535	radical SAM domain protein
KNN15_00375	COG2010	Cytochrome c
KNN15_00385	COG2832	Protein of unknown function (DUF454)
KNN15_00395	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNN15_00400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN15_00430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN15_00435	COG3191	aminopeptidase activity
KNN15_00445	COG1063	alcohol dehydrogenase
KNN15_00450	COG0714	Associated with various cellular activities
KNN15_00465	COG2304	oxidoreductase activity
KNN15_00485	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KNN15_00490	COG2884	Cell division ATP-binding protein ftsE
KNN15_00495	COG0793	Belongs to the peptidase S41A family
KNN15_00500	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN15_00500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN15_00505	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
KNN15_00510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KNN15_00520	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KNN15_00525	COG0159	tryptophan synthase activity
KNN15_00530	COG0133	tryptophan synthase activity
KNN15_00535	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
KNN15_00545	COG1744	ABC transporter substrate-binding protein PnrA-like
KNN15_00550	COG3845	ABC transporter
KNN15_00580	COG0077	Prephenate dehydratase
KNN15_00580	COG1605	Chorismate mutase
KNN15_00620	COG1674	ftsk spoiiie
KNN15_00625	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KNN15_00630	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KNN15_00635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KNN15_00640	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KNN15_00640	COG4651	solute:proton antiporter activity
KNN15_00645	COG0217	transcriptional regulatory protein
KNN15_00650	COG0653	protein targeting
KNN15_00655	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KNN15_00685	COG1960	acyl-CoA dehydrogenase activity
KNN15_00695	COG0312	modulator of DNA gyrase
KNN15_00700	COG0312	modulator of DNA gyrase
KNN15_00720	COG0730	response to heat
KNN15_00745	COG0167	dihydroorotate dehydrogenase activity
KNN15_00770	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KNN15_00775	COG0746	molybdenum cofactor guanylyltransferase activity
KNN15_00780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KNN15_00780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN15_00790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN15_00810	COG0538	isocitrate dehydrogenase activity
KNN15_00815	COG0557	exoribonuclease II activity
KNN15_00825	COG0585	pseudouridine synthase activity
KNN15_00845	COG2050	protein possibly involved in aromatic compounds catabolism
KNN15_00855	COG0322	excinuclease ABC activity
KNN15_00860	COG0018	arginyl-trna synthetase
KNN15_00865	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KNN15_00870	COG1428	Deoxynucleoside kinase
KNN15_00875	COG1428	Deoxynucleoside kinase
KNN15_00880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
KNN15_00885	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
KNN15_00890	COG0107	imidazoleglycerol-phosphate synthase activity
KNN15_00895	COG0140	phosphoribosyl-ATP diphosphatase activity
KNN15_00895	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KNN15_00905	COG1494	fructose-1,6-bisphosphatase
KNN15_00930	COG0395	ABC-type sugar transport system, permease component
KNN15_00935	COG1175	transmembrane transport
KNN15_00975	COG0084	hydrolase, TatD family'
KNN15_00980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KNN15_00990	COG0017	Asparaginyl-tRNA synthetase
KNN15_00995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KNN15_01000	COG1053	succinate dehydrogenase
KNN15_01010	COG2009	succinate dehydrogenase
KNN15_01015	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
KNN15_01045	COG0318	PFAM AMP-dependent synthetase and ligase
KNN15_01050	COG1104	cysteine desulfurase activity
KNN15_01055	COG1959	2 iron, 2 sulfur cluster binding
KNN15_01060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KNN15_01065	COG1121	(ABC) transporter
KNN15_01075	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
KNN15_01080	COG2255	four-way junction helicase activity
KNN15_01100	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KNN15_01110	COG1085	galactose-1-phosphate uridylyltransferase
KNN15_01115	COG3345	alpha-galactosidase
KNN15_01125	COG1181	Belongs to the D-alanine--D-alanine ligase family
KNN15_01130	COG0193	aminoacyl-tRNA hydrolase activity
KNN15_01135	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
KNN15_01140	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KNN15_01145	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KNN15_01150	COG1854	S-ribosylhomocysteine lyase activity
KNN15_01155	COG0519	Catalyzes the synthesis of GMP from XMP
KNN15_01155	COG0518	GMP synthase (glutamine-hydrolyzing) activity
KNN15_01165	COG4274	PFAM GYD family protein
KNN15_01180	COG0328	RNA-DNA hybrid ribonuclease activity
KNN15_01185	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KNN15_01220	COG0590	tRNA wobble adenosine to inosine editing
KNN15_01220	COG0037	tRNA processing
KNN15_01245	COG1877	trehalose-phosphatase activity
KNN15_01250	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
KNN15_01255	COG0366	Alpha amylase catalytic
KNN15_01265	COG2226	methyltransferase
KNN15_01275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
KNN15_01285	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KNN15_01290	COG0460	homoserine dehydrogenase
KNN15_01295	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KNN15_01330	COG0037	tRNA processing
KNN15_01335	COG2104	thiamine diphosphate biosynthetic process
KNN15_01340	COG0123	including yeast histone deacetylase and acetoin utilization protein
KNN15_01345	COG0517	IMP dehydrogenase activity
KNN15_01355	COG0444	Belongs to the ABC transporter superfamily
KNN15_01360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN15_01365	COG0601	transmembrane transport
KNN15_01370	COG0747	negative chemotaxis
KNN15_01375	COG0604	alcohol dehydrogenase
KNN15_01380	COG0492	ferredoxin-NADP+ reductase activity
KNN15_01415	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN15_01420	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KNN15_01425	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KNN15_01445	COG2070	2-Nitropropane dioxygenase
KNN15_01465	COG0745	RESPONSE REGULATOR receiver
KNN15_01470	COG5002	protein histidine kinase activity
KNN15_01490	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KNN15_01495	COG0572	uridine kinase
KNN15_01500	COG0464	growth
KNN15_01510	COG1850	ribulose-bisphosphate carboxylase activity
KNN15_01520	COG0583	DNA-binding transcription factor activity
KNN15_01560	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KNN15_01580	COG0513	Belongs to the DEAD box helicase family
KNN15_01585	COG0303	'Molybdopterin
KNN15_01605	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
KNN15_01610	COG0442	prolyl-tRNA aminoacylation
KNN15_01615	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
KNN15_01625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KNN15_01640	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_01645	COG2816	NAD+ diphosphatase activity
KNN15_01650	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KNN15_01650	COG1213	nucleotidyl transferase
KNN15_01655	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
KNN15_01660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
KNN15_01670	COG1482	cell wall glycoprotein biosynthetic process
KNN15_01680	COG1515	deoxyribonuclease V activity
KNN15_01690	COG0776	regulation of translation
KNN15_01695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KNN15_01700	COG0443	Heat shock 70 kDa protein
KNN15_01705	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
KNN15_01710	COG0484	heat shock protein binding
KNN15_01715	COG0789	Transcriptional regulator
KNN15_01720	COG0542	response to heat
KNN15_01760	COG0490	domain, Protein
KNN15_01765	COG0475	glutathione-regulated potassium exporter activity
KNN15_01785	COG0475	glutathione-regulated potassium exporter activity
KNN15_01795	COG0305	Participates in initiation and elongation during chromosome replication
KNN15_01805	COG0070	glutamate synthase
KNN15_01805	COG0069	glutamate synthase activity
KNN15_01805	COG0067	glutamate synthase
KNN15_01810	COG0247	lactate metabolic process
KNN15_01815	COG1139	Iron-sulfur cluster binding protein
KNN15_01820	COG1139	Iron-sulfur cluster binding protein
KNN15_01825	COG0681	Belongs to the peptidase S26 family
KNN15_01830	COG1752	Esterase of the alpha-beta hydrolase superfamily
KNN15_01835	COG0515	serine threonine protein kinase
KNN15_01835	COG2815	serine threonine protein kinase
KNN15_01845	COG0860	N-Acetylmuramoyl-L-alanine amidase
KNN15_01855	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
KNN15_01875	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
KNN15_01875	COG2199	diguanylate cyclase activity
KNN15_01885	COG0473	3-isopropylmalate dehydrogenase activity
KNN15_01920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
KNN15_01925	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KNN15_01930	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
KNN15_01945	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KNN15_01945	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
KNN15_01950	COG0736	holo-[acyl-carrier-protein] synthase activity
KNN15_01965	COG1160	GTP binding
KNN15_01975	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KNN15_01980	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
KNN15_01980	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KNN15_01985	COG0083	homoserine kinase activity
KNN15_02000	COG0268	Binds directly to 16S ribosomal RNA
KNN15_02010	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
KNN15_02015	COG0723	plastoquinol--plastocyanin reductase activity
KNN15_02025	COG3088	subunit of a heme lyase
KNN15_02025	COG4235	cytochrome complex assembly
KNN15_02030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KNN15_02035	COG1138	Cytochrome C-type biogenesis protein
KNN15_02040	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
KNN15_02045	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KNN15_02055	COG4133	protoheme IX ABC transporter activity
KNN15_02060	COG0785	Cytochrome C biogenesis protein
KNN15_02075	COG0446	pyridine nucleotide-disulphide oxidoreductase
KNN15_02085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KNN15_02090	COG3258	Cytochrome c
KNN15_02095	COG2010	Cytochrome c
KNN15_02100	COG0737	Belongs to the 5'-nucleotidase family
KNN15_02105	COG2010	Cytochrome c
KNN15_02110	COG3258	Cytochrome c
KNN15_02130	COG2010	Cytochrome c
KNN15_02135	COG3842	ATPase activity
KNN15_02155	COG0504	CTP synthase activity
KNN15_02165	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
KNN15_02170	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
KNN15_02195	COG2205	protein histidine kinase activity
KNN15_02205	COG2815	serine threonine protein kinase
KNN15_02205	COG0515	serine threonine protein kinase
KNN15_02210	COG0631	protein serine/threonine phosphatase activity
KNN15_02225	COG0113	porphobilinogen synthase activity
KNN15_02230	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KNN15_02235	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
KNN15_02260	COG4946	Tricorn protease homolog
KNN15_02260	COG0823	Involved in the tonB-independent uptake of proteins
KNN15_02260	COG1506	peptidase
KNN15_02265	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KNN15_02270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
KNN15_02290	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KNN15_02295	COG1011	Hydrolase
KNN15_02300	COG2911	Protein conserved in bacteria
KNN15_02300	COG1361	Conserved repeat domain
KNN15_02300	COG3266	domain, Protein
KNN15_02310	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KNN15_02325	COG0537	adenosine 5'-monophosphoramidase activity
KNN15_02330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN15_02345	COG0135	phosphoribosylanthranilate isomerase activity
KNN15_02350	COG0483	inositol monophosphate 1-phosphatase activity
KNN15_02360	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
KNN15_02365	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
KNN15_02370	COG0714	Associated with various cellular activities
KNN15_02375	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KNN15_02375	COG0574	Belongs to the PEP-utilizing enzyme family
KNN15_02380	COG1272	protein, Hemolysin III
KNN15_02390	COG5002	protein histidine kinase activity
KNN15_02390	COG3850	Histidine kinase
KNN15_02425	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
KNN15_02440	COG0546	phosphoglycolate phosphatase activity
KNN15_02455	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KNN15_02465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KNN15_02475	COG0047	phosphoribosylformylglycinamidine synthase activity
KNN15_02485	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KNN15_02500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
KNN15_02505	COG0497	DNA recombination
KNN15_02515	COG2095	MarC family integral membrane protein
KNN15_02520	COG1438	arginine binding
KNN15_02525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KNN15_02535	COG0194	GDP metabolic process
KNN15_02545	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KNN15_02550	COG2385	sporulation resulting in formation of a cellular spore
KNN15_02555	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
KNN15_02565	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KNN15_02600	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KNN15_02605	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KNN15_02610	COG0142	geranyltranstransferase activity
KNN15_02615	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
KNN15_02645	COG0203	ribosomal protein L17
KNN15_02655	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
KNN15_02660	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
KNN15_02665	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
KNN15_02675	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KNN15_02685	COG0563	adenylate kinase activity
KNN15_02690	COG0201	protein transport
KNN15_02715	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
KNN15_02750	COG0255	Belongs to the universal ribosomal protein uL29 family
KNN15_02755	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KNN15_02760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
KNN15_02770	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KNN15_02775	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
KNN15_02780	COG0089	rRNA binding
KNN15_02785	COG0088	Forms part of the polypeptide exit tunnel
KNN15_02795	COG0051	transcription antitermination factor activity, RNA binding
KNN15_02810	COG0049	tRNA binding
KNN15_02835	COG1461	Dihydroxyacetone kinase
KNN15_02845	COG0686	Belongs to the AlaDH PNT family
KNN15_02850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
KNN15_02855	COG1024	Enoyl-CoA hydratase
KNN15_02860	COG1187	pseudouridine synthase activity
KNN15_02865	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
KNN15_02875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
KNN15_02885	COG0512	Glutamine amidotransferase of anthranilate synthase
KNN15_02890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KNN15_02895	COG1012	belongs to the aldehyde dehydrogenase family
KNN15_02900	COG0506	proline dehydrogenase activity
KNN15_02905	COG1802	Transcriptional regulator
KNN15_02915	COG0156	8-amino-7-oxononanoate synthase activity
KNN15_02930	COG0187	DNA topoisomerase II activity
KNN15_02935	COG1643	Atp-dependent helicase
KNN15_02945	COG1063	alcohol dehydrogenase
KNN15_03000	COG1605	Chorismate mutase
KNN15_03000	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KNN15_03005	COG0805	protein transport
KNN15_03010	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNN15_03015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
KNN15_03020	COG0220	tRNA (guanine-N7-)-methyltransferase activity
KNN15_03035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KNN15_03040	COG0792	nuclease activity
KNN15_03050	COG0492	ferredoxin-NADP+ reductase activity
KNN15_03055	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_03060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KNN15_03075	COG1187	pseudouridine synthase activity
KNN15_03080	COG2720	vancomycin resistance protein
KNN15_03090	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KNN15_03095	COG0427	acetyl-CoA hydrolase
KNN15_03100	COG0686	Belongs to the AlaDH PNT family
KNN15_03115	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
KNN15_03120	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KNN15_03125	COG0071	Belongs to the small heat shock protein (HSP20) family
KNN15_03135	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNN15_03145	COG1764	response to oxidative stress
KNN15_03150	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
KNN15_03165	COG3842	ATPase activity
KNN15_03170	COG0101	tRNA pseudouridine synthase activity
KNN15_03175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN15_03180	COG0601	transmembrane transport
KNN15_03190	COG0316	Belongs to the HesB IscA family
KNN15_03200	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KNN15_03215	COG1166	arginine decarboxylase activity
KNN15_03225	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
KNN15_03230	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
KNN15_03240	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KNN15_03265	COG0366	Alpha amylase catalytic
KNN15_03275	COG1193	negative regulation of DNA recombination
KNN15_03290	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KNN15_03295	COG2226	methyltransferase
KNN15_03300	COG4603	Belongs to the binding-protein-dependent transport system permease family
KNN15_03305	COG1079	Belongs to the binding-protein-dependent transport system permease family
KNN15_03315	COG1774	PSP1 C-terminal conserved region
KNN15_03320	COG0470	DNA polymerase III
KNN15_03355	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KNN15_03370	COG1653	transport
KNN15_03390	COG0723	plastoquinol--plastocyanin reductase activity
KNN15_03395	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KNN15_03400	COG0539	negative regulation of cytoplasmic translation
KNN15_03415	COG0442	prolyl-tRNA aminoacylation
KNN15_03435	COG1115	amino acid carrier protein
KNN15_03455	COG1489	DNA binding
KNN15_03500	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
KNN15_03505	COG1355	regulation of microtubule-based process
KNN15_03520	COG1011	Hydrolase
KNN15_03535	COG0589	response to stress
KNN15_03540	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNN15_03545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KNN15_03555	COG1940	carbohydrate kinase activity
KNN15_03600	COG0302	gtp cyclohydrolase
KNN15_03625	COG0675	Transposase, IS605 OrfB family
KNN15_03650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KNN15_03655	COG0395	ABC-type sugar transport system, permease component
KNN15_03660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KNN15_03670	COG1131	(ABC) transporter
KNN15_03690	COG0556	nucleotide-excision repair
KNN15_03695	COG0497	DNA recombination
KNN15_03700	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
KNN15_03755	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KNN15_03760	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KNN15_03800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KNN15_03805	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
KNN15_03810	COG0343	queuine tRNA-ribosyltransferase activity
KNN15_03815	COG0628	permease
KNN15_03825	COG0227	Belongs to the bacterial ribosomal protein bL28 family
KNN15_03830	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
KNN15_03840	COG0436	Aminotransferase
KNN15_03850	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
KNN15_03855	COG1597	lipid kinase activity
KNN15_03880	COG0123	including yeast histone deacetylase and acetoin utilization protein
KNN15_03885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KNN15_03895	COG0004	ammonium transporteR
KNN15_03900	COG0347	Belongs to the P(II) protein family
KNN15_03905	COG1420	regulation of RNA biosynthetic process
KNN15_03910	COG0314	molybdopterin synthase activity
KNN15_03920	COG4636	protein conserved in cyanobacteria
KNN15_03925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
KNN15_03930	COG1960	acyl-CoA dehydrogenase activity
KNN15_03940	COG0495	leucyl-tRNA aminoacylation
KNN15_03950	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
KNN15_03955	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KNN15_03970	COG2096	Adenosyltransferase
KNN15_03980	COG4555	ABC transporter
KNN15_03985	COG1668	transmembrane transport
KNN15_04010	COG1660	Displays ATPase and GTPase activities
KNN15_04015	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KNN15_04030	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KNN15_04035	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KNN15_04050	COG1715	Restriction endonuclease
KNN15_04060	COG0072	phenylalanine-tRNA ligase activity
KNN15_04060	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KNN15_04070	COG0205	6-phosphofructokinase activity
KNN15_04075	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KNN15_04085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
KNN15_04090	COG0584	glycerophosphoryl diester phosphodiesterase
KNN15_04105	COG0658	competence protein
KNN15_04105	COG2333	competence protein COMEC
KNN15_04110	COG1475	DNA binding
KNN15_04115	COG1192	Involved in chromosome partitioning
KNN15_04120	COG0357	Ribosomal RNA small subunit methyltransferase G
KNN15_04125	COG0445	tRNA wobble uridine modification
KNN15_04130	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
KNN15_04135	COG0592	DNA-directed DNA polymerase activity
KNN15_04140	COG0148	phosphopyruvate hydratase activity
KNN15_04145	COG0469	pyruvate kinase activity
KNN15_04165	COG0631	protein serine/threonine phosphatase activity
KNN15_04170	COG0105	UTP biosynthetic process
KNN15_04180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KNN15_04210	COG0315	cyclic pyranopterin monophosphate synthase activity
KNN15_04225	COG2010	Cytochrome c
KNN15_04230	COG0535	radical SAM domain protein
KNN15_04240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNN15_04245	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
KNN15_04255	COG1842	Phage shock protein A
KNN15_04265	COG1131	(ABC) transporter
KNN15_04270	COG0842	Transport permease protein
KNN15_04285	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KNN15_04295	COG1278	Cold shock
KNN15_04300	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
KNN15_04325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
KNN15_04345	COG1547	Domain of unknown function (DUF309)
KNN15_04370	COG2414	aldehyde ferredoxin oxidoreductase
KNN15_04380	COG0604	alcohol dehydrogenase
KNN15_04400	COG1902	pentaerythritol trinitrate reductase activity
KNN15_04415	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KNN15_04445	COG1131	(ABC) transporter
KNN15_04470	COG3956	TIGRFAM MazG family protein
KNN15_04480	COG0693	protein deglycase activity
KNN15_04485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KNN15_04495	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KNN15_04500	COG1937	Protein conserved in bacteria
KNN15_04510	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN15_04510	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN15_04515	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN15_04540	COG0459	protein refolding
KNN15_04545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KNN15_04555	COG0714	Associated with various cellular activities
KNN15_04565	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNN15_04575	COG0166	Belongs to the GPI family
KNN15_04580	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
KNN15_04585	COG1612	heme a metabolic process
KNN15_04585	COG0109	protoheme IX farnesyltransferase activity
KNN15_04595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN15_04595	COG1845	cytochrome c oxidase, subunit III
KNN15_04615	COG1845	cytochrome c oxidase, subunit III
KNN15_04625	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN15_04630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNN15_04655	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
KNN15_04660	COG2814	Major facilitator Superfamily
KNN15_04665	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KNN15_04670	COG0581	inorganic phosphate transmembrane transporter activity
KNN15_04675	COG0573	inorganic phosphate transmembrane transporter activity
KNN15_04685	COG0482	sulfurtransferase activity
KNN15_04705	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
KNN15_04710	COG0735	belongs to the Fur family
KNN15_04725	COG0583	DNA-binding transcription factor activity
KNN15_04730	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
KNN15_04735	COG0508	dehydrogenase complex catalyzes the overall conversion of
KNN15_04740	COG0181	hydroxymethylbilane synthase activity
KNN15_04750	COG0285	dihydrofolate synthase activity
KNN15_04755	COG0436	Aminotransferase
KNN15_04760	COG0521	Mo-molybdopterin cofactor biosynthetic process
KNN15_04775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KNN15_04780	COG0154	amidase activity
KNN15_04785	COG0301	tRNA thio-modification
KNN15_04795	COG0243	molybdopterin cofactor binding
KNN15_04805	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
KNN15_04815	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KNN15_04820	COG1653	transport
KNN15_04835	COG0033	Phosphoglucomutase
KNN15_04850	COG2223	nitrite transmembrane transporter activity
KNN15_04870	COG0516	GMP reductase activity
KNN15_04870	COG0517	IMP dehydrogenase activity
KNN15_04875	COG1950	PFAM Membrane protein of
KNN15_04895	COG0406	alpha-ribazole phosphatase activity
KNN15_04900	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
KNN15_04905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNN15_04915	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KNN15_04920	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KNN15_04925	COG1496	oxidoreductase activity
KNN15_04935	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
KNN15_04940	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KNN15_04945	COG1993	acr, cog1993
KNN15_04950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KNN15_04960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KNN15_04970	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KNN15_04975	COG1335	isochorismatase
KNN15_04980	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KNN15_04985	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
KNN15_05015	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
KNN15_05020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KNN15_05025	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KNN15_05030	COG0250	Participates in transcription elongation, termination and antitermination
KNN15_05040	COG0081	regulation of translation
KNN15_05045	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
KNN15_05050	COG0222	ribosome binding
KNN15_05055	COG0163	prenyltransferase activity
KNN15_05070	COG2226	methyltransferase
KNN15_05085	COG1960	acyl-CoA dehydrogenase activity
KNN15_05090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KNN15_05095	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNN15_05105	COG1598	PFAM Uncharacterised protein family UPF0150
KNN15_05110	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KNN15_05115	COG0066	3-isopropylmalate dehydratase activity
KNN15_05130	COG0189	ligase activity
KNN15_05135	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KNN15_05140	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
KNN15_05145	COG1543	Belongs to the glycosyl hydrolase 57 family
KNN15_05150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KNN15_05150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KNN15_05155	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
KNN15_05170	COG0445	tRNA wobble uridine modification
KNN15_05210	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KNN15_05235	COG0791	NLP P60 protein
KNN15_05235	COG1388	LysM domain
KNN15_05240	COG0778	Nitroreductase
KNN15_05245	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KNN15_05250	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KNN15_05255	COG0477	Major facilitator Superfamily
KNN15_05265	COG1694	Mazg nucleotide pyrophosphohydrolase
KNN15_05270	COG1803	Methylglyoxal synthase
KNN15_05280	COG2271	Major facilitator Superfamily
KNN15_05300	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
KNN15_05325	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
KNN15_05330	COG0359	binds to the 23S rRNA
KNN15_05350	COG0321	lipoyl(octanoyl) transferase activity
KNN15_05355	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
KNN15_05380	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KNN15_05395	COG1598	PFAM Uncharacterised protein family UPF0150
KNN15_05400	COG0022	dehydrogenase e1 component
KNN15_05405	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KNN15_05410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
KNN15_05435	COG2226	methyltransferase
KNN15_05450	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KNN15_05460	COG0668	transmembrane transport
KNN15_05465	COG3253	May function as heme-dependent peroxidase
KNN15_05495	COG0642	Histidine kinase
KNN15_05510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KNN15_05515	COG1136	(ABC) transporter
KNN15_05520	COG0577	efflux transmembrane transporter activity
KNN15_05520	COG1136	(ABC) transporter
KNN15_05530	COG0632	four-way junction helicase activity
KNN15_05535	COG1024	Enoyl-CoA hydratase
KNN15_05545	COG0508	dehydrogenase complex catalyzes the overall conversion of
KNN15_05560	COG1404	Belongs to the peptidase S8 family
KNN15_05570	COG0137	argininosuccinate synthase activity
KNN15_05575	COG0165	Argininosuccinate lyase
KNN15_05580	COG0165	Argininosuccinate lyase
KNN15_05580	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KNN15_05595	COG0505	Belongs to the CarA family
KNN15_05600	COG2759	Belongs to the formate--tetrahydrofolate ligase family
KNN15_05650	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KNN15_05655	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KNN15_05660	COG0662	Cupin 2, conserved barrel domain protein
KNN15_05660	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
KNN15_05680	COG0438	transferase activity, transferring glycosyl groups
KNN15_05695	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KNN15_05700	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
KNN15_05705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN15_05720	COG2244	polysaccharide biosynthetic process
KNN15_05725	COG0438	transferase activity, transferring glycosyl groups
KNN15_05740	COG0438	transferase activity, transferring glycosyl groups
KNN15_05745	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KNN15_05760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
KNN15_05765	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KNN15_05770	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
KNN15_05775	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
KNN15_05790	COG0799	negative regulation of ribosome biogenesis
KNN15_05795	COG4636	protein conserved in cyanobacteria
KNN15_05805	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
KNN15_05840	COG0739	heme binding
KNN15_05850	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
KNN15_05855	COG0825	malonyl-CoA metabolic process
KNN15_05875	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KNN15_05885	COG1278	Cold shock
KNN15_05890	COG0484	heat shock protein binding
KNN15_05895	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KNN15_05900	COG1968	undecaprenyl-diphosphatase activity
KNN15_05905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
KNN15_05910	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
KNN15_05925	COG1309	transcriptional regulator
KNN15_05930	COG4242	Belongs to the peptidase S51 family
KNN15_05945	COG0802	atpase or kinase
KNN15_05965	COG0437	4 iron, 4 sulfur cluster binding
KNN15_06000	COG3706	GGDEF domain
KNN15_06005	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KNN15_06010	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KNN15_06015	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KNN15_06020	COG1185	polyribonucleotide nucleotidyltransferase activity
KNN15_06025	COG3118	belongs to the thioredoxin family
KNN15_06030	COG0416	fatty acid biosynthetic process
KNN15_06040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KNN15_06050	COG1404	Belongs to the peptidase S8 family
KNN15_06055	COG0284	orotidine-5'-phosphate decarboxylase activity
KNN15_06060	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KNN15_06070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
KNN15_06090	COG0822	iron-sulfur transferase activity
KNN15_06095	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KNN15_06105	COG2132	Multicopper oxidase
KNN15_06130	COG2226	methyltransferase
KNN15_06145	COG5002	protein histidine kinase activity
KNN15_06150	COG0745	RESPONSE REGULATOR receiver
KNN15_06175	COG2146	nitrite reductase [NAD(P)H] activity
KNN15_06180	COG0719	Fe-S assembly protein
KNN15_06185	COG0719	Fe-S assembly protein
KNN15_06190	COG0396	ATPase activity
KNN15_06200	COG2224	Isocitrate lyase
KNN15_06205	COG0446	pyridine nucleotide-disulphide oxidoreductase
KNN15_06215	COG0577	efflux transmembrane transporter activity
KNN15_06215	COG1136	(ABC) transporter
KNN15_06235	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
KNN15_06245	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
KNN15_06270	COG4948	Mandelate Racemase Muconate Lactonizing
KNN15_06290	COG1058	Belongs to the CinA family
KNN15_06290	COG1546	Belongs to the CinA family
KNN15_06295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KNN15_06305	COG1418	mRNA catabolic process
KNN15_06305	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
KNN15_06320	COG1077	Cell shape determining protein MreB Mrl
KNN15_06325	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KNN15_06345	COG0235	Class ii aldolase
KNN15_06375	COG1177	transmembrane transport
KNN15_06380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KNN15_06385	COG1607	acyl-coa hydrolase
KNN15_06390	COG2154	pterin-4-alpha-carbinolamine dehydratase
KNN15_06400	COG0277	FAD linked oxidase domain protein
KNN15_06430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KNN15_06445	COG4555	ABC transporter
KNN15_06450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
KNN15_06460	COG0667	Aldo Keto reductase
KNN15_06475	COG0516	GMP reductase activity
KNN15_06475	COG0517	IMP dehydrogenase activity
KNN15_06485	COG1067	ATP-dependent peptidase activity
KNN15_06490	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
KNN15_06500	COG0745	RESPONSE REGULATOR receiver
KNN15_06505	COG2105	PFAM AIG2 family protein
KNN15_06520	COG0297	glycogen (starch) synthase activity
KNN15_06530	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KNN15_06535	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
KNN15_06550	COG0142	geranyltranstransferase activity
KNN15_06560	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
KNN15_06585	COG4974	Belongs to the 'phage' integrase family
KNN15_07020	COG3300	MHYT domain
KNN15_07020	COG5001	Diguanylate cyclase
KNN15_07035	COG0516	GMP reductase activity
KNN15_07035	COG0517	IMP dehydrogenase activity
KNN15_07050	COG2205	protein histidine kinase activity
KNN15_07070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNN15_07085	COG1324	tolerance protein
KNN15_07090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KNN15_07095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
KNN15_07100	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KNN15_07105	COG2197	response regulator
KNN15_07120	COG1132	(ABC) transporter
KNN15_07125	COG1132	(ABC) transporter
KNN15_07130	COG0285	dihydrofolate synthase activity
KNN15_07140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN15_07145	COG0601	transmembrane transport
KNN15_07150	COG0747	negative chemotaxis
KNN15_07180	COG0174	glutamine synthetase
KNN15_07185	COG0737	Belongs to the 5'-nucleotidase family
KNN15_07205	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
KNN15_07210	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
KNN15_07215	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
KNN15_07220	COG0788	formyltetrahydrofolate deformylase activity
KNN15_07235	COG2358	TRAP transporter, solute receptor (TAXI family
KNN15_07255	COG2814	Major facilitator Superfamily
KNN15_07260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KNN15_07265	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNN15_07270	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
KNN15_07290	COG2050	protein possibly involved in aromatic compounds catabolism
KNN15_07295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KNN15_07315	COG0247	lactate metabolic process
KNN15_07320	COG0277	FAD linked oxidase domain protein
KNN15_07325	COG0277	FAD linked oxidase domain protein
KNN15_07330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
KNN15_07335	COG1414	Transcriptional regulator
KNN15_07340	COG0789	Transcriptional regulator
KNN15_07355	COG2045	Belongs to the ComB family
KNN15_07360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KNN15_07365	COG1136	(ABC) transporter
KNN15_07375	COG1024	Enoyl-CoA hydratase
KNN15_07385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KNN15_07390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KNN15_07405	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KNN15_07425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KNN15_07440	COG2890	protein-(glutamine-N5) methyltransferase activity
KNN15_07445	COG1837	Belongs to the UPF0109 family
KNN15_07450	COG0706	membrane insertase activity
KNN15_07455	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
KNN15_07475	COG1022	Amp-dependent synthetase and ligase
KNN15_07500	COG0564	pseudouridine synthase activity
KNN15_07505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KNN15_07510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KNN15_07515	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KNN15_07520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KNN15_07525	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_07530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KNN15_07535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNN15_07540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KNN15_07560	COG1007	ATP synthesis coupled electron transport
KNN15_07565	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN15_07570	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KNN15_07575	COG0713	ATP synthesis coupled electron transport
KNN15_07580	COG0839	Belongs to the complex I subunit 6 family
KNN15_07585	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN15_07590	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
KNN15_07595	COG1034	ATP synthesis coupled electron transport
KNN15_07600	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KNN15_07605	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
KNN15_07610	COG0649	NAD binding
KNN15_07615	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN15_07620	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN15_07625	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
KNN15_07630	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KNN15_07640	COG4712	double-strand break repair protein
KNN15_07675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KNN15_07680	COG0131	Imidazoleglycerol-phosphate dehydratase
KNN15_07685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
KNN15_07690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KNN15_07695	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KNN15_07725	COG0861	Integral membrane protein TerC family
KNN15_07730	COG2151	metal-sulfur cluster biosynthetic enzyme
KNN15_07745	COG1714	RDD family
KNN15_07750	COG0616	signal peptide processing
KNN15_07755	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KNN15_07760	COG0372	Belongs to the citrate synthase family
KNN15_07765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KNN15_07775	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KNN15_07780	COG0758	DNA mediated transformation
KNN15_07780	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
KNN15_07785	COG3546	catalase activity
KNN15_07790	COG0583	DNA-binding transcription factor activity
KNN15_07800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KNN15_07805	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
KNN15_07810	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
KNN15_07820	COG0717	Belongs to the dCTP deaminase family
KNN15_07835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
KNN15_07835	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KNN15_07840	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_07845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
KNN15_07870	COG0515	serine threonine protein kinase
KNN15_07870	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KNN15_07880	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KNN15_07905	COG0675	Transposase, IS605 OrfB family
KNN15_07910	COG0704	Plays a role in the regulation of phosphate uptake
KNN15_07915	COG2205	protein histidine kinase activity
KNN15_07920	COG0745	RESPONSE REGULATOR receiver
KNN15_07930	COG0582	viral genome integration into host DNA
KNN15_08010	COG1857	crispr-associated protein
KNN15_08030	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KNN15_08085	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KNN15_08095	COG1653	transport
KNN15_08105	COG1175	transmembrane transport
KNN15_08115	COG1737	Transcriptional regulator
KNN15_08120	COG0584	glycerophosphoryl diester phosphodiesterase
KNN15_08140	COG2361	Protein of unknown function DUF86
KNN15_08165	COG1349	DNA-binding transcription factor activity
KNN15_08175	COG0434	BtpA family
KNN15_08190	COG0395	ABC-type sugar transport system, permease component
KNN15_08200	COG1175	transmembrane transport
KNN15_08205	COG3842	ATPase activity
KNN15_08210	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KNN15_08220	COG1178	ABC-type Fe3 transport system permease component
KNN15_08225	COG1177	transmembrane transport
KNN15_08230	COG3842	ATPase activity
KNN15_08250	COG0395	ABC-type sugar transport system, permease component
KNN15_08255	COG1175	transmembrane transport
KNN15_08300	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
KNN15_08305	COG1126	abc transporter atp-binding protein
KNN15_08310	COG0765	amino acid transport
KNN15_08315	COG4597	amino acid ABC transporter
KNN15_08320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNN15_08325	COG0829	nickel cation binding
KNN15_08330	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
KNN15_08335	COG0830	nickel cation binding
KNN15_08340	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
KNN15_08345	COG0804	urea catabolic process
KNN15_08350	COG0832	Belongs to the urease beta subunit family
KNN15_08350	COG0831	urea catabolic process
KNN15_08360	COG0010	Belongs to the arginase family
KNN15_08375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNN15_08385	COG0831	urea catabolic process
KNN15_08435	COG0494	nUDIX hydrolase
KNN15_08440	COG0281	malic enzyme
KNN15_08455	COG0404	The glycine cleavage system catalyzes the degradation of glycine
KNN15_08460	COG0509	glycine decarboxylation via glycine cleavage system
KNN15_08465	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KNN15_08470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
KNN15_08475	COG0196	riboflavin kinase activity
KNN15_08500	COG2813	Specifically methylates the guanine in position
KNN15_08510	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
KNN15_08520	COG0358	DNA primase activity
KNN15_08535	COG1205	dead DEAH box helicase
KNN15_08535	COG1111	helicase
KNN15_08540	COG0456	acetyltransferase
KNN15_08550	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
KNN15_08555	COG0009	L-threonylcarbamoyladenylate synthase
KNN15_08560	COG1459	type II secretion system
KNN15_08580	COG3706	GGDEF domain
KNN15_08585	COG0287	Prephenate dehydrogenase
KNN15_08590	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KNN15_08610	COG2353	YceI-like domain
KNN15_08615	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
KNN15_08620	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
KNN15_08645	COG0179	Fumarylacetoacetate (FAA) hydrolase
KNN15_08655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KNN15_08660	COG0151	Belongs to the GarS family
KNN15_08665	COG5002	protein histidine kinase activity
KNN15_08665	COG2176	DNA-directed DNA polymerase activity
KNN15_08675	COG2205	protein histidine kinase activity
KNN15_08690	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KNN15_08695	COG3162	membrane
KNN15_08700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNN15_08705	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNN15_08710	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KNN15_08720	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN15_08720	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN15_08730	COG1733	regulation of RNA biosynthetic process
KNN15_08735	COG2894	cell division
KNN15_08740	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
KNN15_08745	COG0772	Belongs to the SEDS family
KNN15_08750	COG3842	ATPase activity
KNN15_08755	COG1176	ABC-type spermidine putrescine transport system, permease component I
KNN15_08760	COG1177	transmembrane transport
KNN15_08765	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
KNN15_08770	COG2010	Cytochrome c
KNN15_08775	COG0129	dihydroxy-acid dehydratase activity
KNN15_08780	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_08800	COG0066	3-isopropylmalate dehydratase activity
KNN15_08805	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
KNN15_08825	COG0180	Tryptophanyl-tRNA synthetase
KNN15_08855	COG2165	general secretion pathway protein
KNN15_08865	COG4966	pilus assembly protein PilW
KNN15_08875	COG4970	Tfp pilus assembly protein FimT
KNN15_08885	COG0183	Belongs to the thiolase family
KNN15_08910	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KNN15_08915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KNN15_08930	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KNN15_08935	COG1254	Belongs to the acylphosphatase family
KNN15_08945	COG1063	alcohol dehydrogenase
KNN15_08955	COG2133	pyrroloquinoline quinone binding
KNN15_08960	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
KNN15_08985	COG0420	3'-5' exonuclease activity
KNN15_08990	COG0419	ATPase involved in DNA repair
KNN15_09005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KNN15_09010	COG0612	Peptidase, M16
KNN15_09015	COG0612	Peptidase, M16
KNN15_09020	COG0697	spore germination
KNN15_09025	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNN15_09045	COG4956	integral membrane protein (PIN domain superfamily)
KNN15_09050	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KNN15_09055	COG0542	response to heat
KNN15_09060	COG0423	glycine-tRNA ligase activity
KNN15_09065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KNN15_09085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
KNN15_09085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNN15_09090	COG1024	Enoyl-CoA hydratase
KNN15_09095	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KNN15_09105	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KNN15_09115	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNN15_09120	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
KNN15_09125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KNN15_09135	COG0861	Integral membrane protein TerC family
KNN15_09140	COG0492	ferredoxin-NADP+ reductase activity
KNN15_09145	COG0028	Belongs to the TPP enzyme family
KNN15_09150	COG0440	acetolactate synthase activity
KNN15_09155	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
KNN15_09165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KNN15_09180	COG4555	ABC transporter
KNN15_09200	COG2165	general secretion pathway protein
KNN15_09220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNN15_09230	COG1573	uracil-dna glycosylase
KNN15_09250	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KNN15_09265	COG1316	TRANSCRIPTIONal
KNN15_09295	COG0515	serine threonine protein kinase
KNN15_09295	COG2815	serine threonine protein kinase
KNN15_09300	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
KNN15_09320	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KNN15_09330	COG1269	ATP hydrolysis coupled proton transport
KNN15_09340	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
KNN15_09345	COG1527	subunit (C
KNN15_09350	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
KNN15_09355	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
KNN15_09360	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
KNN15_09365	COG1394	ATPase activity, coupled to movement of substances
KNN15_09370	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KNN15_09420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KNN15_09430	COG1760	l-serine dehydratase
KNN15_09440	COG0481	GTPase activity
KNN15_09445	COG1960	acyl-CoA dehydrogenase activity
KNN15_09450	COG0183	Belongs to the thiolase family
KNN15_09460	COG1804	L-carnitine dehydratase bile acid-inducible protein F
KNN15_09465	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_09500	COG1012	belongs to the aldehyde dehydrogenase family
KNN15_09535	COG2030	dehydratase
KNN15_09540	COG2267	carboxylic ester hydrolase activity
KNN15_09545	COG0596	Alpha beta hydrolase
KNN15_09555	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KNN15_09580	COG2909	trisaccharide binding
KNN15_09585	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNN15_09585	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KNN15_09590	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
KNN15_09600	COG0195	Participates in both transcription termination and antitermination
KNN15_09605	COG0779	Required for maturation of 30S ribosomal subunits
KNN15_09620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KNN15_09620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KNN15_09630	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KNN15_09630	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
KNN15_09645	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN15_09645	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN15_09650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN15_09650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
KNN15_09655	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KNN15_09680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KNN15_09685	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
KNN15_09690	COG1702	phosphate starvation-inducible protein PhoH
KNN15_09700	COG4864	UPF0365 protein
KNN15_09710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KNN15_09725	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KNN15_09730	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
KNN15_09735	COG0824	Thioesterase
KNN15_09745	COG0557	exoribonuclease II activity
KNN15_09750	COG1355	regulation of microtubule-based process
KNN15_09755	COG0617	tRNA 3'-terminal CCA addition
KNN15_09755	COG1353	crispr-associated protein
KNN15_09760	COG0237	dephospho-CoA kinase activity
KNN15_09765	COG4221	oxidoreductase activity
KNN15_09775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
KNN15_09810	COG0165	Argininosuccinate lyase
KNN15_09815	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KNN15_09835	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KNN15_09840	COG1185	polyribonucleotide nucleotidyltransferase activity
KNN15_09845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
KNN15_09860	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KNN15_09865	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KNN15_09875	COG1100	Small GTP-binding protein
KNN15_09890	COG0010	Belongs to the arginase family
KNN15_09910	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
KNN15_09915	COG0511	ligase activity, forming carbon-carbon bonds
KNN15_09920	COG0439	Biotin carboxylase
KNN15_09930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KNN15_09935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
KNN15_09940	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KNN15_09950	COG0247	lactate metabolic process
KNN15_09950	COG2181	nitrate reductase activity
KNN15_09960	COG0861	Integral membrane protein TerC family
KNN15_09965	COG2819	hydrolase of the alpha beta superfamily
KNN15_09975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KNN15_09980	COG0438	transferase activity, transferring glycosyl groups
KNN15_10025	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
KNN15_10030	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
KNN15_10040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KNN15_10045	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNN15_10065	COG0582	viral genome integration into host DNA
KNN15_10080	COG2189	Belongs to the N(4) N(6)-methyltransferase family
KNN15_10165	COG3845	ABC transporter
KNN15_10170	COG4603	Belongs to the binding-protein-dependent transport system permease family
KNN15_10175	COG1079	Belongs to the binding-protein-dependent transport system permease family
KNN15_10185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KNN15_10190	COG0494	nUDIX hydrolase
KNN15_10200	COG0138	bifunctional purine biosynthesis protein purh
KNN15_10210	COG2337	Toxic component of a toxin-antitoxin (TA) module
KNN15_10220	COG3239	Fatty acid desaturase
KNN15_10235	COG5001	Diguanylate cyclase
KNN15_10235	COG3706	GGDEF domain
KNN15_10235	COG4251	negative regulation of phosphorylation
KNN15_10235	COG2203	Gaf domain
KNN15_10240	COG1490	D-aminoacyl-tRNA deacylase activity
KNN15_10245	COG1307	EDD domain protein, DegV family
KNN15_10250	COG1307	EDD domain protein, DegV family
KNN15_10255	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KNN15_10270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KNN15_10280	COG1012	belongs to the aldehyde dehydrogenase family
KNN15_10285	COG2368	4-hydroxyphenylacetate
KNN15_10290	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KNN15_10320	COG2050	protein possibly involved in aromatic compounds catabolism
KNN15_10325	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
KNN15_10340	COG1492	cobalamin metabolic process
KNN15_10345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
KNN15_10355	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KNN15_10355	COG0574	Belongs to the PEP-utilizing enzyme family
KNN15_10360	COG2723	6-phospho-beta-galactosidase activity
KNN15_10370	COG1175	transmembrane transport
KNN15_10380	COG1609	Transcriptional regulator
KNN15_10385	COG1378	Sugar-specific transcriptional regulator TrmB
KNN15_10390	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KNN15_10395	COG0022	dehydrogenase e1 component
KNN15_10405	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KNN15_10415	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
KNN15_10415	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
KNN15_10420	COG2271	Major facilitator Superfamily
KNN15_10430	COG1175	transmembrane transport
KNN15_10435	COG3842	ATPase activity
KNN15_10440	COG3290	protein histidine kinase activity
KNN15_10445	COG4565	transcriptional regulatory protein
KNN15_10455	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
KNN15_10485	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNN15_10500	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
KNN15_10505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KNN15_10510	COG0601	transmembrane transport
KNN15_10520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KNN15_10530	COG2226	methyltransferase
KNN15_10535	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KNN15_10550	COG0589	response to stress
KNN15_10565	COG1993	acr, cog1993
KNN15_10580	COG1193	negative regulation of DNA recombination
KNN15_10585	COG1193	negative regulation of DNA recombination
KNN15_10595	COG2205	protein histidine kinase activity
KNN15_10600	COG0745	RESPONSE REGULATOR receiver
KNN15_10605	COG2010	Cytochrome c
KNN15_10610	COG1914	H( )-stimulated, divalent metal cation uptake system
KNN15_10630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNN15_10635	COG2323	membrane
KNN15_10675	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KNN15_10675	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
KNN15_10700	COG1063	alcohol dehydrogenase
KNN15_10715	COG3181	Tripartite tricarboxylate transporter family receptor
KNN15_10725	COG2186	Transcriptional regulator
KNN15_10740	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KNN15_10770	COG4638	Rieske (2fe-2S)
KNN15_10820	COG1942	4-Oxalocrotonate Tautomerase
KNN15_10845	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
KNN15_10875	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
KNN15_10880	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
KNN15_10890	COG1797	cobyrinic acid a,c-diamide synthase activity
KNN15_10895	COG2046	Belongs to the sulfate adenylyltransferase family
KNN15_10900	COG1648	precorrin-2 dehydrogenase activity
KNN15_10900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KNN15_10905	COG0730	response to heat
KNN15_10910	COG0175	sulfate reduction
KNN15_10915	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KNN15_10915	COG1648	precorrin-2 dehydrogenase activity
KNN15_10920	COG1587	Uroporphyrinogen-III synthase
KNN15_10925	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KNN15_10930	COG0352	thiamine-phosphate diphosphorylase activity
KNN15_10935	COG2104	thiamine diphosphate biosynthetic process
KNN15_10940	COG2022	thiamine diphosphate biosynthetic process
KNN15_10945	COG2022	thiamine diphosphate biosynthetic process
KNN15_10945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN15_10950	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
KNN15_10965	COG0351	phosphomethylpyrimidine kinase
KNN15_10970	COG1785	Belongs to the alkaline phosphatase family
KNN15_10975	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_11010	COG1012	belongs to the aldehyde dehydrogenase family
KNN15_11010	COG2030	dehydratase
KNN15_11015	COG1960	acyl-CoA dehydrogenase activity
KNN15_11020	COG1309	transcriptional regulator
KNN15_11025	COG1980	fructose-bisphosphate aldolase activity
KNN15_11040	COG0395	ABC-type sugar transport system, permease component
KNN15_11045	COG1175	transmembrane transport
KNN15_11065	COG1607	acyl-coa hydrolase
KNN15_11070	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KNN15_11085	COG4974	Belongs to the 'phage' integrase family
KNN15_11095	COG3396	Phenylacetate-CoA oxygenase
KNN15_11105	COG3396	Phenylacetate-CoA oxygenase
KNN15_11115	COG2030	dehydratase
KNN15_11115	COG1012	belongs to the aldehyde dehydrogenase family
KNN15_11120	COG1733	regulation of RNA biosynthetic process
KNN15_11125	COG2193	ferroxidase activity
KNN15_11130	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KNN15_11135	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
KNN15_11155	COG1331	Highly conserved protein containing a thioredoxin domain
KNN15_11160	COG0183	Belongs to the thiolase family
KNN15_11165	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KNN15_11170	COG0477	Major facilitator Superfamily
KNN15_11180	COG1960	acyl-CoA dehydrogenase activity
KNN15_11185	COG2414	aldehyde ferredoxin oxidoreductase
KNN15_11195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KNN15_11205	COG0803	Belongs to the bacterial solute-binding protein 9 family
KNN15_11210	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KNN15_11215	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
KNN15_11225	COG3383	formate dehydrogenase (NAD+) activity
KNN15_11230	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
KNN15_11240	COG5002	protein histidine kinase activity
KNN15_11245	COG1960	acyl-CoA dehydrogenase activity
KNN15_11250	COG2086	electron transfer activity
KNN15_11255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KNN15_11265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KNN15_11270	COG2197	response regulator
KNN15_11280	COG1573	uracil-dna glycosylase
KNN15_11285	COG1796	DNA polymerase
KNN15_11285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KNN15_11300	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
KNN15_11300	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
KNN15_11300	COG1013	pyruvate-flavodoxin oxidoreductase activity
KNN15_11300	COG0674	pyruvate-flavodoxin oxidoreductase activity
KNN15_11310	COG2873	o-acetylhomoserine
KNN15_11325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KNN15_11330	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
KNN15_11335	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KNN15_11345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
KNN15_11350	COG0215	cysteine-tRNA ligase activity
KNN15_11355	COG1960	acyl-CoA dehydrogenase activity
KNN15_11360	COG0183	Belongs to the thiolase family
KNN15_11365	COG1024	Enoyl-CoA hydratase
KNN15_11365	COG1250	3-hydroxyacyl-CoA dehydrogenase
KNN15_11370	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KNN15_11390	COG1215	transferase activity, transferring glycosyl groups
KNN15_11405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KNN15_11405	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
KNN15_11410	COG1811	Na channel or pump
KNN15_11415	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
KNN15_11420	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
KNN15_11425	COG4948	Mandelate Racemase Muconate Lactonizing
KNN15_11435	COG0402	S-adenosylhomocysteine deaminase activity
KNN15_11460	COG2319	Wd-40 repeat
KNN15_11470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
KNN15_11475	COG0742	ribosomal rna small subunit methyltransferase
KNN15_11490	COG2873	o-acetylhomoserine
KNN15_11495	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
KNN15_11500	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
KNN15_11505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
KNN15_11565	COG0535	radical SAM domain protein
KNN15_11585	COG0149	triose-phosphate isomerase activity
KNN15_11590	COG0126	phosphoglycerate kinase activity
KNN15_11600	COG1268	BioY protein
KNN15_11610	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
KNN15_11625	COG1196	nuclear chromosome segregation
KNN15_11640	COG2738	Putative neutral zinc metallopeptidase
KNN15_11645	COG2897	thiosulfate sulfurtransferase activity
KNN15_11650	COG1760	l-serine dehydratase
KNN15_11655	COG2197	response regulator
KNN15_11660	COG0335	large ribosomal subunit rRNA binding
KNN15_11665	COG0336	Belongs to the RNA methyltransferase TrmD family
KNN15_11670	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
KNN15_11680	COG0228	four-way junction DNA binding
KNN15_11690	COG2239	Acts as a magnesium transporter
KNN15_11700	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
KNN15_11715	COG1692	metallophosphoesterase
KNN15_11745	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KNN15_11750	COG1410	methionine synthase
KNN15_11750	COG0646	methionine synthase
KNN15_11760	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
KNN15_11765	COG0740	serine-type endopeptidase activity
KNN15_11770	COG0544	peptidyl-prolyl cis-trans isomerase activity
KNN15_11790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KNN15_11795	COG3870	Protein conserved in bacteria
KNN15_11800	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KNN15_11810	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
KNN15_11820	COG1595	DNA-templated transcription, initiation
KNN15_11840	COG4475	Protein of unknown function (DUF436)
KNN15_11860	COG0651	ATP synthesis coupled electron transport
KNN15_11875	COG0651	ATP synthesis coupled electron transport
KNN15_11890	COG3842	ATPase activity
KNN15_11915	COG2176	DNA-directed DNA polymerase activity
KNN15_11920	COG0154	amidase activity
KNN15_11925	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
KNN15_11935	COG1435	thymidine kinase activity
KNN15_11940	COG0254	rRNA binding
KNN15_12075	COG4383	Mu-like prophage protein gp29
KNN15_12215	COG5005	Phage virion morphogenesis
KNN15_12245	COG2001	Belongs to the MraZ family
KNN15_12250	COG0275	rRNA processing
KNN15_12260	COG0768	penicillin binding
KNN15_12265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KNN15_12275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KNN15_12280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KNN15_12285	COG0772	Belongs to the SEDS family
KNN15_12290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KNN15_12295	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
KNN15_12300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
KNN15_12320	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
KNN15_12340	COG2391	methyltransferase activity
KNN15_12345	COG0702	epimerase
KNN15_12350	COG0243	molybdopterin cofactor binding
KNN15_12380	COG1028	Short-chain dehydrogenase reductase Sdr
KNN15_12395	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KNN15_12415	COG1175	transmembrane transport
KNN15_12445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KNN15_12450	COG2264	protein methyltransferase activity
KNN15_12460	COG0489	protein tyrosine kinase activity
KNN15_12470	COG0525	valine-tRNA ligase activity
KNN15_12480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KNN15_12490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
KNN15_12495	COG0134	indole-3-glycerol-phosphate synthase activity
KNN15_12500	COG1752	Esterase of the alpha-beta hydrolase superfamily
KNN15_12510	COG1126	abc transporter atp-binding protein
KNN15_12520	COG2358	TRAP transporter, solute receptor (TAXI family
KNN15_12525	COG0765	amino acid transport
KNN15_12530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KNN15_12540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KNN15_12545	COG0569	domain protein
KNN15_12550	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KNN15_12560	COG2313	pseudouridylate synthase activity
KNN15_12570	COG3001	Fructosamine kinase
KNN15_12575	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KNN15_12580	COG4585	Histidine kinase
KNN15_12605	COG0012	GTP binding
KNN15_12610	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
KNN15_12620	COG0424	maF-like protein
KNN15_12625	COG0459	protein refolding
KNN15_12635	COG0768	penicillin binding
KNN15_12645	COG2322	membrane
KNN15_12665	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
KNN15_12670	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
KNN15_12680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KNN15_12695	COG3842	ATPase activity
KNN15_12705	COG0124	histidyl-tRNA synthetase
KNN15_12715	COG0384	phenazine biosynthesis protein PhzF
KNN15_12720	COG0561	phosphatase activity
KNN15_12735	COG0745	RESPONSE REGULATOR receiver
KNN15_12745	COG0017	Asparaginyl-tRNA synthetase
KNN15_12750	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
KNN15_12755	COG2217	Heavy metal translocating P-type atpase
KNN15_12760	COG0640	Transcriptional regulator
KNN15_12765	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
KNN15_12770	COG0739	heme binding
KNN15_12775	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KNN15_12780	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
KNN15_12785	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KNN15_12790	COG4636	protein conserved in cyanobacteria
KNN15_12795	COG0006	proline dipeptidase activity
KNN15_12800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KNN15_12805	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
KNN15_12815	COG1994	Peptidase M50
KNN15_12825	COG0517	IMP dehydrogenase activity
KNN15_12825	COG0617	tRNA 3'-terminal CCA addition
KNN15_12825	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KNN15_12860	COG3335	DDE superfamily endonuclease
KNN15_12905	COG1475	DNA binding
KNN15_12940	COG0671	phosphoesterase, PA-phosphatase related
KNN15_12955	COG2205	protein histidine kinase activity
KNN15_12970	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
KNN15_12985	COG2197	response regulator
KNN15_12990	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KNN15_13010	COG0515	serine threonine protein kinase
KNN15_13015	COG1116	anion transmembrane transporter activity
KNN15_13080	COG1692	metallophosphoesterase
KNN15_13130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released