locus-tag	class	description
TO73_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
TO73_0003	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TO73_0005	ENOG41067HZ	cytochrome C, class I
TO73_0007	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TO73_0008	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
TO73_0011	ENOG41087YS	Phage shock protein A
TO73_0013	ENOG4105C6T	cysteine synthase
TO73_0014	ENOG4108YZY	peptidylprolyl cis-trans isomerase
TO73_0015	ENOG4105VEQ	Cold shock protein
TO73_0016	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TO73_0022	ENOG4107ZT3	family UPF0126
TO73_0023	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
TO73_0028	ENOG4105C0B	DNA polymerase III (alpha subunit)
TO73_0029	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TO73_0030	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
TO73_0031	ENOG4108RWN	rrna methyltransferase
TO73_0035	ENOG4107T3P	ABC, transporter
TO73_0040	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
TO73_0044	ENOG4105CSH	Transporter
TO73_0046	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TO73_0047	ENOG41082T9	Membrane
TO73_0055	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TO73_0056	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TO73_0057	ENOG4105CZX	twitching motility protein
TO73_0058	ENOG4107QHF	type ii secretion system protein e
TO73_0059	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
TO73_0060	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
TO73_0062	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
TO73_0063	ENOG4105WMR	Protein CrcB homolog
TO73_0064	ENOG4105KJJ	Uncharacterized ACR, COG1993
TO73_0067	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
TO73_0069	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
TO73_0070	ENOG4105SYT	Methylenetetrahydrofolate reductase
TO73_0071	ENOG4105CY0	Metallo-Beta-Lactamase
TO73_0071	ENOG4105CY0	Metallo-Beta-Lactamase
TO73_0080	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TO73_0081	ENOG4105WDJ	50S ribosomal protein L33
TO73_0082	ENOG410683Z	Preprotein translocase SecE subunit
TO73_0083	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
TO73_0084	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TO73_0085	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TO73_0086	ENOG4108VZM	50s ribosomal protein L10
TO73_0087	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
TO73_0088	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TO73_0089	ENOG4105C1G	acyl-Coa dehydrogenase
TO73_0090	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TO73_0091	ENOG4108JZA	Homocitrate synthase
TO73_0094	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TO73_0095	ENOG4108S93	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TO73_0097	ENOG4106928	lysine biosynthesis protein LysW
TO73_0098	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
TO73_0099	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TO73_0100	ENOG4107U4Q	acetylglutamate kinase
TO73_0101	ENOG4107RFW	hydrolase family 57
TO73_0103	ENOG4105C4K	Nad synthetase
TO73_0104	ENOG4105K4P	CoA-binding domain protein
TO73_0105	ENOG4105CEN	a g-specific adenine glycosylase
TO73_0111	ENOG41068JE	domain protein
TO73_0114	ENOG4105CTD	carboxy-peptidase
TO73_0115	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
TO73_0116	ENOG4105CN9	Peptidase m42 family protein
TO73_0117	ENOG4108Z5K	methylglyoxal synthase
TO73_0118	ENOG4105C0P	Mg chelatase subunit ChlI
TO73_0122	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
TO73_0123	ENOG4105W8H	transhydrogenase (subunit alpha
TO73_0124	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
TO73_0126	ENOG41082AW	Binds together with S18 to 16S ribosomal RNA (By similarity)
TO73_0127	ENOG4105Z8H	single-stranded DNA-binding protein
TO73_0128	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
TO73_0129	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
TO73_0130	ENOG4105DMF	Dehydrogenase
TO73_0131	ENOG4105E1F	short-chain dehydrogenase reductase
TO73_0132	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
TO73_0133	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
TO73_0136	ENOG4107QN2	dihydrolipoyl dehydrogenase
TO73_0139	ENOG4105CPP	Dehydrogenase, E1 component
TO73_0140	ENOG4107SUU	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
TO73_0141	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
TO73_0143	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
TO73_0146	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
TO73_0147	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
TO73_0149	ENOG4105D8X	mechanosensitive ion channel
TO73_0150	ENOG4107T9V	chlorite dismutase
TO73_0152	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
TO73_0153	ENOG4108UKI	Enoyl-CoA hydratase
TO73_0154	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
TO73_0155	ENOG4105C7S	Dehydrogenase
TO73_0156	ENOG4107QN2	dihydrolipoyl dehydrogenase
TO73_0157	ENOG4108QT4	peptidase S8 and S53, subtilisin, kexin, sedolisin
TO73_0159	ENOG4105CDH	Citrulline--aspartate ligase
TO73_0160	ENOG4105CH7	arginosuccinase
TO73_0164	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
TO73_0165	ENOG4105CKU	formyltetrahydrofolate synthetase
TO73_0170	ENOG4107R08	Integrase
TO73_0172	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
TO73_0178	ENOG4105ENA	helicase
TO73_0214	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
TO73_0215	ENOG4105K46	50S ribosomal protein l27
TO73_0216	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TO73_0217	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
TO73_0220	ENOG4105KEM	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)
TO73_0222	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
TO73_0223	ENOG4105CZX	twitching motility protein
TO73_0227	ENOG4105DR5	peptidase
TO73_0229	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
TO73_0230	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
TO73_0235	ENOG4108Z4U	Ferredoxin
TO73_0238	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TO73_0239	ENOG4105C5R	Aminotransferase
TO73_0240	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
TO73_0241	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
TO73_0242	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
TO73_0245	ENOG4107Z3H	Transcriptional regulator, TetR family
TO73_0247	ENOG4105HYT	Uncharacterized metal-binding protein (DUF2227)
TO73_0253	ENOG4107SFQ	iron-sulfur binding
TO73_0258	ENOG4105BZU	Histidine kinase
TO73_0259	ENOG4108KB0	deacetylase
TO73_0260	ENOG4105C8Y	Acetylornithine aminotransferase
TO73_0263	ENOG4105CPK	Glycosyl transferase (Group 1
TO73_0265	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TO73_0266	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TO73_0268	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
TO73_0269	ENOG4106FU4	Archease protein family (MTH1598/TM1083)
TO73_0270	ENOG4107YEI	lmbE family
TO73_0274	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
TO73_0275	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TO73_0277	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
TO73_0279	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
TO73_0281	ENOG4108UNV	SUF system FeS assembly protein, NifU family
TO73_0282	ENOG4105C9B	Cysteine desulfurase
TO73_0292	ENOG4105DIW	FeS assembly protein SUFB
TO73_0293	ENOG4105C3K	feS assembly ATPase SufC
TO73_0296	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TO73_0298	ENOG4108I0Y	(ABC) transporter
TO73_0299	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TO73_0301	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TO73_0303	ENOG4106B0N	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
TO73_0305	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
TO73_0315	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
TO73_0317	ENOG4108784	2'-5' rna ligase
TO73_0318	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TO73_0319	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
TO73_0320	ENOG4105DFF	Rod shape-determining protein mreb
TO73_0321	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
TO73_0323	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TO73_0324	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TO73_0325	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
TO73_0330	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
TO73_0333	ENOG41090A4	Pterin carbinolamine dehydratase
TO73_0336	ENOG4105CQB	FAD linked oxidase domain protein
TO73_0343	ENOG4105EZY	Pyrroloquinoline quinone biosynthesis protein E
TO73_0347	ENOG4105CPC	Aldo Keto reductase
TO73_0350	ENOG4105CUJ	penicillin amidase
TO73_0351	ENOG4105DAN	ATP-dependent protease
TO73_0352	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
TO73_0354	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TO73_0356	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
TO73_0357	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
TO73_0358	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
TO73_0361	ENOG4105EAH	synthase
TO73_0363	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TO73_0371	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
TO73_0372	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TO73_0373	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TO73_0374	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TO73_0375	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TO73_0376	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TO73_0377	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
TO73_0378	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TO73_0379	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TO73_0380	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TO73_0381	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
TO73_0382	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
TO73_0383	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
TO73_0384	ENOG4108CHD	50s ribosomal protein l29
TO73_0386	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TO73_0387	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TO73_0388	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TO73_0392	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TO73_0393	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TO73_0394	ENOG410856V	50S ribosomal protein L30
TO73_0395	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TO73_0396	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
TO73_0397	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TO73_0399	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
TO73_0400	ENOG41067V7	50S ribosomal protein L36
TO73_0401	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TO73_0402	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TO73_0403	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TO73_0404	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TO73_0405	ENOG4108ZT0	50S ribosomal protein l17
TO73_0407	ENOG4108Q5Y	Membrane
TO73_0415	ENOG4105D82	Glutamate dehydrogenase
TO73_0416	ENOG4105D82	Glutamate dehydrogenase
TO73_0422	ENOG4105E63	Pfam:DUF178
TO73_0424	ENOG41074B2	UPF0747 protein
TO73_0425	ENOG4105JFG	SpoIID LytB domain protein
TO73_0426	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
TO73_0428	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
TO73_0429	ENOG41079SJ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
TO73_0430	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TO73_0431	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
TO73_0432	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
TO73_0434	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
TO73_0437	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
TO73_0440	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
TO73_0442	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
TO73_0444	ENOG4105C8V	SAICAR synthetase
TO73_0447	ENOG4105C83	adenylosuccinate lyase
TO73_0453	ENOG4108Z8I	decarboxylase
TO73_0455	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
TO73_0462	ENOG41062D9	Histidine kinase
TO73_0466	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TO73_0467	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TO73_0468	ENOG4108UKM	mov34 mpn pad-1 family protein
TO73_0470	ENOG4105ECY	inositol monophosphatase
TO73_0471	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
TO73_0472	ENOG4107S45	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TO73_0473	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TO73_0474	ENOG4107YU2	histidine triad (hIT) protein
TO73_0476	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TO73_0478	ENOG4107GBW	cellulosome anchoring protein cohesin
TO73_0479	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
TO73_0480	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
TO73_0484	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TO73_0485	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
TO73_0486	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TO73_0491	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
TO73_0492	ENOG41080DW	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
TO73_0493	ENOG4105D52	delta-aminolevulinic acid dehydratase
TO73_0496	ENOG4108ZF3	Phosphatase
TO73_0497	ENOG4105D9P	serine threonine protein kinase
TO73_0498	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TO73_0503	ENOG4105C4R	Atp-dependent dna helicase
TO73_0504	ENOG4108UJD	30S ribosomal protein S9
TO73_0505	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TO73_0506	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TO73_0511	ENOG4108IJ6	ABC transporter
TO73_0512	ENOG41067HZ	cytochrome C, class I
TO73_0516	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
TO73_0517	ENOG4105QN4	diheme cytochrome
TO73_0520	ENOG4107S7U	Sulfide dehydrogenase
TO73_0521	ENOG4105CCD	The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)
TO73_0523	ENOG4107QIV	Cytochrome c biogenesis protein
TO73_0524	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
TO73_0525	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
TO73_0526	ENOG41060IM	Heme exporter protein
TO73_0527	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
TO73_0528	ENOG4105DA4	cytochrome c-type biogenesis protein
TO73_0529	ENOG4107QX9	Thiol disulfide interChange protein
TO73_0530	ENOG4105KWW	Biogenesis protein
TO73_0534	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
TO73_0536	ENOG4108AH5	Binds directly to 16S ribosomal RNA (By similarity)
TO73_0538	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
TO73_0541	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TO73_0542	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TO73_0546	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TO73_0549	ENOG41084ZW	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
TO73_0550	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TO73_0551	ENOG4105D49	3-dehydroquinate synthase
TO73_0552	ENOG4107ZC0	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
TO73_0553	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
TO73_0554	ENOG4105K44	type iii secretion
TO73_0559	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TO73_0561	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TO73_0567	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
TO73_0569	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
TO73_0570	ENOG4105D9P	serine threonine protein kinase
TO73_0571	ENOG4105D78	K07001 NTE family protein
TO73_0572	ENOG4105C3F	Signal peptidase i
TO73_0573	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
TO73_0574	ENOG4107QR9	Iron-sulfur cluster binding protein
TO73_0575	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
TO73_0577	ENOG41065SU	Two-component system sensor kinase
TO73_0581	ENOG4108W63	CRP FNR family transcriptional regulator
TO73_0584	ENOG4105VF7	tolerance protein
TO73_0585	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TO73_0586	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
TO73_0587	ENOG4105E4C	Lytic transglycosylase catalytic
TO73_0588	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TO73_0589	ENOG4105WH1	Two component transcriptional regulator luxr family
TO73_0592	ENOG4105BZ1	(ABC) transporter
TO73_0593	ENOG4105BZ1	(ABC) transporter
TO73_0594	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TO73_0596	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TO73_0597	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TO73_0598	ENOG4105DEF	Extracellular solute-binding protein, family 5
TO73_0599	ENOG4108IV0	ABC, transporter
TO73_0600	ENOG4105C0Z	ABC transporter
TO73_0601	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TO73_0602	ENOG4105C32	Amino acid ABC transporter (Permease)
TO73_0604	ENOG4105C5F	glutamine synthetase
TO73_0605	ENOG4105CGH	5'-nucleotidase
TO73_0607	ENOG41067HZ	cytochrome C, class I
TO73_0609	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TO73_0610	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
TO73_0611	ENOG4105CIY	formyltetrahydrofolate deformylase
TO73_0612	ENOG4105C0H	protease
TO73_0615	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TO73_0619	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
TO73_0621	ENOG4105ESV	Glycosyl transferase, family 4
TO73_0622	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
TO73_0627	ENOG4107R9S	Malate synthase
TO73_0628	ENOG4107HP6	Transcriptional regulator
TO73_0629	ENOG4105KNI	merR family transcriptional Regulator
TO73_0630	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TO73_0631	ENOG4108N5B	2-phosphosulfolactate phosphatase
TO73_0632	ENOG4105IJJ	transcriptional regulator, crp fnr family
TO73_0633	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
TO73_0634	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
TO73_0635	ENOG4105E39	Enoyl-CoA hydratase
TO73_0640	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TO73_0641	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TO73_0646	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TO73_0648	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
TO73_0649	ENOG4108IUZ	ABC transporter
TO73_0651	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
TO73_0652	ENOG4105VB6	UPF0109 protein
TO73_0653	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
TO73_0655	ENOG4105VG0	50S ribosomal protein l34
TO73_0656	ENOG4105C0Z	ABC transporter
TO73_0657	ENOG4105CEY	Amp-dependent synthetase and ligase
TO73_0658	ENOG4105C32	Amino acid ABC transporter (Permease)
TO73_0659	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TO73_0661	ENOG4108IV0	ABC, transporter
TO73_0662	ENOG4105CHR	reductase
TO73_0663	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
TO73_0664	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TO73_0665	ENOG41067VY	50S ribosomal protein L32
TO73_0680	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TO73_0684	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
TO73_0685	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TO73_0687	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
TO73_0689	ENOG4105CHV	Transcription elongation factor NusA
TO73_0690	ENOG410836C	Required for maturation of 30S ribosomal subunits (By similarity)
TO73_0693	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
TO73_0694	ENOG4108R6K	riboflavin synthase, subunit alpha
TO73_0695	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
TO73_0699	ENOG4105D5P	Methylmalonyl-coA mutase
TO73_0702	ENOG4105CRK	lysyL-tRNA synthetase
TO73_0703	ENOG4105RTX	GreA GreB family elongation factor
TO73_0705	ENOG41080IJ	Diacylglycerol kinase
TO73_0706	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
TO73_0707	ENOG4105C9A	Phoh family
TO73_0707	ENOG4105C9A	Phoh family
TO73_0709	ENOG4105DI5	UPF0365 protein
TO73_0711	ENOG4105E2X	shikimate dehydrogenase
TO73_0712	ENOG4105C2M	dna polymerase I
TO73_0714	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TO73_0717	ENOG4105C8Y	Acetylornithine aminotransferase
TO73_0718	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
TO73_0719	ENOG41081CK	Memo-like protein
TO73_0721	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
TO73_0724	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TO73_0725	ENOG4106IQC	argininosuccinate lyase
TO73_0730	ENOG4105CJW	magnesium transporter
TO73_0732	ENOG41081QV	Universal stress protein
TO73_0733	ENOG4105CN5	Metallo-Beta-Lactamase
TO73_0734	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TO73_0735	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TO73_0738	ENOG4107RQ2	Cytochrome c oxidase, subunit I
TO73_0739	ENOG4105NAA	Cytochrome C oxidase, subunit II
TO73_0741	ENOG4105CXV	gliding motility protein
TO73_0744	ENOG4105CYW	agmatinase
TO73_0748	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
TO73_0749	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
TO73_0750	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
TO73_0752	ENOG41082MB	Involved in the transcription termination process (By similarity)
TO73_0753	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
TO73_0756	ENOG4105DF6	Fe-S oxidoreductase
TO73_0758	ENOG4108SA1	esterase
TO73_0762	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TO73_0773	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
TO73_0775	ENOG4107TAE	Glycosyl transferase (Group 1
TO73_0779	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
TO73_0782	ENOG4105DG6	mannose-6-phosphate isomerase
TO73_0784	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
TO73_0785	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
TO73_0786	ENOG4105D3Q	Sugar transferase
TO73_0788	ENOG4105CPK	Glycosyl transferase (Group 1
TO73_0792	ENOG41060A7	DNA polymerase beta domain protein region
TO73_0794	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
TO73_0795	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
TO73_0804	ENOG4107R08	Integrase
TO73_0807	ENOG4105CEC	DNA methylase N-4 N-6
TO73_0831	ENOG4105F2C	Acetyl-CoA acetyltransferase
TO73_0837	ENOG4105C2J	ABC transporter
TO73_0838	ENOG4105UIB	(ABC) transporter
TO73_0841	ENOG4108JPW	Aminotransferase
TO73_0842	ENOG4108YZ4	nudix hydrolase
TO73_0844	ENOG4105DC1	bifunctional purine biosynthesis protein purh
TO73_0845	ENOG4105ECK	Fatty Acid Desaturase
TO73_0846	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
TO73_0847	ENOG4105EPR	degv family
TO73_0848	ENOG4105EPR	degv family
TO73_0851	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TO73_0853	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
TO73_0854	ENOG4105CE4	GlcNAc 6-P deacetylase
TO73_0857	ENOG4105E7W	lamb ycsf family protein
TO73_0858	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TO73_0861	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TO73_0862	ENOG4107NFR	Fructose-1,6-bisphosphatase
TO73_0864	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
TO73_0865	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TO73_0867	ENOG4105K8R	UPF0145 protein
TO73_0868	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
TO73_0869	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
TO73_0871	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TO73_0872	ENOG4107RIQ	Sulfate adenylate transferase
TO73_0873	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TO73_0874	ENOG4107TSN	permease
TO73_0875	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
TO73_0876	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TO73_0877	ENOG4105EXQ	uroporphyrinogen iii synthase hem4
TO73_0878	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
TO73_0881	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
TO73_0882	ENOG4105EHG	Permease protein
TO73_0883	ENOG4107R4I	Periplasmic binding protein
TO73_0884	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
TO73_0885	ENOG4108G2S	Thiamine biosynthesis protein thiS
TO73_0886	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
TO73_0887	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
TO73_0888	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
TO73_0889	ENOG4105DWF	phosphomethylpyrimidine kinase
TO73_0891	ENOG4105DRS	transport system, permease
TO73_0900	ENOG4105D5G	Transposase
TO73_0907	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TO73_0908	ENOG4108IV0	ABC, transporter
TO73_0909	ENOG4105C0Z	ABC transporter
TO73_0910	ENOG4105CEY	Amp-dependent synthetase and ligase
TO73_0912	ENOG4105C32	Amino acid ABC transporter (Permease)
TO73_0921	ENOG4105CHR	reductase
TO73_0923	ENOG4105CEY	Amp-dependent synthetase and ligase
TO73_0929	ENOG4105CEY	Amp-dependent synthetase and ligase
TO73_0930	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
TO73_0932	ENOG4108Z7G	MaoC domain protein dehydratase
TO73_0934	ENOG4105C32	Amino acid ABC transporter (Permease)
TO73_0936	ENOG4105C2J	ABC transporter
TO73_0937	ENOG4108IV0	ABC, transporter
TO73_0945	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
TO73_0946	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
TO73_0949	ENOG4107RGC	Glycosyl transferase, family 2
TO73_0950	ENOG4105G6Z	alkaline phosphatase
TO73_0951	ENOG4105D8C	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)
TO73_0956	ENOG4105CP9	extracellular ligand-binding receptor
TO73_0958	ENOG4108IV0	ABC, transporter
TO73_0959	ENOG4105C0Z	ABC transporter
TO73_0961	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TO73_0968	ENOG4108RZE	Tetr family transcriptional regulator
TO73_0969	ENOG4105C1G	acyl-Coa dehydrogenase
TO73_0970	ENOG4105DXM	phenylacetic acid degradation protein
TO73_0971	ENOG4105CHR	reductase
TO73_0972	ENOG4108UQY	Iron-storage protein
TO73_0973	ENOG4105KVH	Transcriptional regulator
TO73_0974	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TO73_0978	ENOG4105ZHF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
TO73_0985	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
TO73_0987	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
TO73_0991	ENOG4105DXM	phenylacetic acid degradation protein
TO73_0994	ENOG4105DZS	Phenylacetate-CoA ligase
TO73_0995	ENOG4107YAU	phenylacetic acid degradation protein
TO73_0996	ENOG4108IV0	ABC, transporter
TO73_0997	ENOG4105C0Z	ABC transporter
TO73_1001	ENOG4105MXW	flavin reductase domain protein, FMN-binding
TO73_1002	ENOG4105EFA	4-hydroxyphenylacetate
TO73_1003	ENOG4105C26	Dehydrogenase
TO73_1005	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TO73_1007	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TO73_1009	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
TO73_1010	ENOG4108P62	biosynthesis protein (CbiG)
TO73_1011	ENOG4105E4R	Precorrin-3B C17-methyltransferase
TO73_1012	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
TO73_1013	ENOG4105DVK	Precorrin-2 c20-methyltransferase
TO73_1014	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
TO73_1015	ENOG41081F0	Precorrin-8x methylmutase
TO73_1016	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
TO73_1017	ENOG4105D9G	High-affinity
TO73_1018	ENOG4105CHU	acetyl-coa acetyltransferase
TO73_1019	ENOG4108IYU	L-aspartate oxidase
TO73_1020	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TO73_1023	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
TO73_1024	ENOG4105C7Z	Conserved Protein
TO73_1025	ENOG4105P4J	Allophanate hydrolase, subunit 1
TO73_1026	ENOG4105CSU	acyl-Coa dehydrogenase
TO73_1027	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TO73_1031	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
TO73_1036	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TO73_1039	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
TO73_1040	ENOG4105CH5	extracellular solute-binding protein, family 7
TO73_1041	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
TO73_1042	ENOG4105BZU	Histidine kinase
TO73_1043	ENOG4105C1G	acyl-Coa dehydrogenase
TO73_1044	ENOG4105BZJ	Electron transfer flavoprotein
TO73_1045	ENOG4105C10	Electron transfer flavoprotein
TO73_1047	ENOG4108HNZ	carboxyl transferase
TO73_1048	ENOG4105E50	uracil-dna glycosylase
TO73_1049	ENOG4105DCG	PHP domain protein
TO73_1052	ENOG4105C88	aminopeptidase
TO73_1053	ENOG4108FXY	Cys/Met metabolism PLP-dependent enzyme
TO73_1054	ENOG41068KF	Universal stress protein
TO73_1056	ENOG4105D7T	ABC transporter
TO73_1057	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
TO73_1058	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
TO73_1059	ENOG4105C8N	cysteinyl-tRNA synthetase
TO73_1060	ENOG4105C1G	acyl-Coa dehydrogenase
TO73_1061	ENOG4105CHU	acetyl-coa acetyltransferase
TO73_1064	ENOG4108JA2	transcriptioN-repair coupling factor
TO73_1068	ENOG4107V8I	Glycosyl transferases group 1
TO73_1069	ENOG4105K64	Glycosyl transferase, family 2
TO73_107	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TO73_1072	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
TO73_1073	ENOG4108UQV	Membrane
TO73_1075	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TO73_1076	ENOG4105DTQ	mandelate racemase muconate lactonizing
TO73_1078	ENOG4107Y3Y	amidohydrolase
TO73_1081	ENOG4105KHN	chorismate mutase
TO73_1084	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
TO73_1085	ENOG4106H78	methyltransferase
TO73_1090	ENOG4108IQK	o-acetylhomoserine
TO73_1091	ENOG4105DWV	Homoserine O-trans-acetylase
TO73_1092	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
TO73_1094	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
TO73_1096	ENOG4107RUY	(E1 component), alpha subunit
TO73_1098	ENOG4105CP7	Triose-phosphate isomerase
TO73_1100	ENOG4105BZA	Phosphoglycerate kinase
TO73_1101	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
TO73_1102	ENOG4107ZYJ	bioY protein
TO73_1105	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
TO73_1106	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
TO73_1108	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TO73_1113	ENOG4105KHC	sulfurtransferase
TO73_1114	ENOG4105EJQ	L-serine dehydratase
TO73_1115	ENOG4105WH1	Two component transcriptional regulator luxr family
TO73_1116	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
TO73_1117	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
TO73_1118	ENOG4106GF2	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
TO73_1120	ENOG4105K5M	30s ribosomal protein S16
TO73_1121	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TO73_1122	ENOG4105CJW	magnesium transporter
TO73_1124	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
TO73_1127	ENOG4105D48	metallophosphoesterase
TO73_1130	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
TO73_1132	ENOG4105CRQ	synthase (Component I)
TO73_1134	ENOG4105C3R	Methionine synthase
TO73_1135	ENOG4105DAP	Nicotinate phosphoribosyltransferase
TO73_1136	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
TO73_1137	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TO73_1138	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
TO73_1144	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
TO73_1145	ENOG4105X0R	protein from nitrogen regulatory protein P-II
TO73_1147	ENOG41066UU	tRNA (Adenine-N1-)-methyltransferase
TO73_1149	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
TO73_1151	ENOG4108UIC	UPF0340 protein
TO73_1154	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
TO73_1159	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
TO73_1160	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TO73_1161	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TO73_1163	ENOG4107104	thymidine kinase
TO73_1164	ENOG41082DI	50s ribosomal protein l31
TO73_1212	ENOG4107XYH	virion morphogenesis protein
TO73_1220	ENOG4108V6E	Cell division protein mraZ
TO73_1221	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
TO73_1223	ENOG4105CJN	penicillin-binding protein
TO73_1226	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
TO73_1227	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
TO73_1228	ENOG4105CNI	cell division protein FtsW
TO73_1229	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
TO73_1230	ENOG4105DFU	Cell wall formation (By similarity)
TO73_1231	ENOG4107QWW	Cell wall formation (By similarity)
TO73_1233	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
TO73_1235	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
TO73_1236	ENOG4105WH1	Two component transcriptional regulator luxr family
TO73_1239	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TO73_1240	ENOG4105DB1	molybdopterin oxidoreductase
TO73_1244	ENOG4105CUC	YeeE YedE family protein
TO73_1245	ENOG4105ECP	epimerase
TO73_1246	ENOG41090K0	Transcriptional regulator, Crp Fnr family
TO73_1248	ENOG4105FE1	phytoene synthase
TO73_1249	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
TO73_1256	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
TO73_1263	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
TO73_1264	ENOG4107R5H	iron (metal) dependent repressor, dtxr family
TO73_1268	ENOG4105EHG	Permease protein
TO73_1269	ENOG4105E0A	ABC, transporter
TO73_1272	ENOG4107S1E	Beta-lactamase
TO73_1282	ENOG4105D1F	ATP-binding protein
TO73_1285	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TO73_1287	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
TO73_1289	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
TO73_1290	ENOG4105DK0	Indole-3-glycerol phosphate synthase
TO73_1291	ENOG4105D78	K07001 NTE family protein
TO73_1295	ENOG4105E5Q	amino acid AbC transporter
TO73_1296	ENOG4105EAB	amino acid AbC transporter
TO73_1298	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
TO73_1299	ENOG4105C1A	potassium transporter peripheral membrane
TO73_1300	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TO73_1302	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
TO73_1305	ENOG4105KJF	protein tyrosine phosphatase
TO73_1307	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
TO73_1308	ENOG4108JQC	penicillin-binding protein 1A
TO73_1312	ENOG4105C3G	gtp-binding protein
TO73_1313	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TO73_1315	ENOG4108Z03	MAF-like protein
TO73_1318	ENOG4105CJN	penicillin-binding protein
TO73_1320	ENOG4108SJC	Membrane
TO73_1324	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
TO73_1325	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TO73_1327	ENOG4105DBV	ornithine carbamoyltransferase
TO73_1329	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TO73_1335	ENOG4105CJ1	ABC, transporter
TO73_1338	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TO73_1340	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TO73_1341	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
TO73_1343	ENOG4105C7K	acetolactate synthase
TO73_1344	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
TO73_1345	ENOG4105EE5	Membrane protein terC
TO73_1346	ENOG4105C9Q	fumarate hydratase class II
TO73_1347	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
TO73_1348	ENOG41080X4	futalosine nucleosidase
TO73_1349	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TO73_1351	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
TO73_1352	ENOG410868C	50s ribosomal protein l35
TO73_1353	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
TO73_1354	ENOG4108D7R	p-hydroxycinnamoyl CoA hydratase lyase
TO73_1355	ENOG4105CX6	glutaminyL-tRNA synthetase
TO73_1362	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TO73_1364	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TO73_1365	ENOG4105CTP	PilT protein domain protein
TO73_1367	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
TO73_1368	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
TO73_1369	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
TO73_1370	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
TO73_1371	ENOG4107Y9U	Membrane
TO73_1372	ENOG4105C1V	Peptidase, M16
TO73_1373	ENOG4105C1V	Peptidase, M16
TO73_1379	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
TO73_1388	ENOG4105EYH	Exonuclease
TO73_1395	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TO73_1398	ENOG4105CPQ	Dehydrogenase
TO73_1400	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TO73_1401	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TO73_1404	ENOG4105DFA	alanine racemase domain protein
TO73_1405	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TO73_1412	ENOG4106855	Competence protein
TO73_1424	ENOG4105C31	Tryptophanyl-tRNA synthetase
TO73_1427	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TO73_1428	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TO73_1429	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TO73_1432	ENOG4105CHR	reductase
TO73_1433	ENOG4105C01	Dihydroxy-acid dehydratase
TO73_1434	ENOG41067HZ	cytochrome C, class I
TO73_1436	ENOG4105D38	putrescine abc transporter
TO73_1437	ENOG4105F38	ABC transporter, permease
TO73_1438	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TO73_1439	ENOG4105CNI	cell division protein FtsW
TO73_1440	ENOG4108CHF	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
TO73_1442	ENOG4105KVH	Transcriptional regulator
TO73_1446	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TO73_1447	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TO73_1448	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TO73_1450	ENOG4107QN1	sodium solute
TO73_1454	ENOG4105BZU	Histidine kinase
TO73_1455	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
TO73_1456	ENOG4108IRC	dna polymerase iii
TO73_1457	ENOG4107QNG	Phosphoribosylglycinamide synthetase
TO73_1458	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
TO73_1460	ENOG4105ERH	Fumarylacetoacetate hydrolase
TO73_1461	ENOG41071YG	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TO73_1465	ENOG4105DVY	radical SAM domain protein
TO73_1466	ENOG4108XHF	Pfam:DUF178
TO73_1469	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
TO73_1470	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TO73_1472	ENOG4105BZU	Histidine kinase
TO73_1473	ENOG4105CQB	FAD linked oxidase domain protein
TO73_1479	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TO73_1480	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
TO73_1482	ENOG4108RTV	Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity)
TO73_1483	ENOG4105C1G	acyl-Coa dehydrogenase
TO73_1485	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TO73_1486	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
TO73_1491	ENOG4105CXT	aspartate transcarbamylase
TO73_1492	ENOG4105CD3	dihydroorotase
TO73_1494	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
TO73_1496	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TO73_1497	ENOG41080QG	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
TO73_1500	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TO73_1504	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
TO73_1505	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TO73_1509	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
TO73_1511	ENOG4105KA0	thioesterase Superfamily protein
TO73_1512	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
TO73_1514	ENOG4105C75	arginyL-tRNA synthetase
TO73_1515	ENOG4105C0H	protease
TO73_1518	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
TO73_1519	ENOG4108JIF	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
TO73_1521	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
TO73_1522	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
TO73_1524	ENOG4105CBT	Fructose-1,6-bisphosphatase
TO73_1531	ENOG4105F8V	Hydrolase, tatD family
TO73_1534	ENOG4105C5S	asparaginyl-tRNA synthetase
TO73_1535	ENOG4105E33	succinate dehydrogenase
TO73_1539	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TO73_1541	ENOG4105CIG	ABC transporter
TO73_1545	ENOG4105CEY	Amp-dependent synthetase and ligase
TO73_1546	ENOG4107QI6	Cysteine desulfurase
TO73_1547	ENOG410847I	Transcriptional regulator, BadM Rrf2 family
TO73_1548	ENOG4105CC5	ABC transporter
TO73_1549	ENOG4105DIK	(ABC) transporter
TO73_1550	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
TO73_1551	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TO73_1552	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
TO73_1553	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
TO73_1554	ENOG4105DZS	Phenylacetate-CoA ligase
TO73_1555	ENOG4107Y7Q	pfkb domain protein
TO73_1556	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
TO73_1557	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
TO73_1558	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TO73_1575	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TO73_1576	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TO73_1577	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TO73_1578	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TO73_1579	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TO73_1580	ENOG4105GKE	subunit e
TO73_1581	ENOG4107EEP	NADH dehydrogenase (quinone) (EC 1.6.99.5)
TO73_1582	ENOG4108IEH	NADH dehydrogenase subunit g
TO73_1583	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
TO73_1584	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TO73_1585	ENOG41087XN	oxidoreductase
TO73_1586	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TO73_1587	ENOG4105D65	subunit l
TO73_1588	ENOG4107WFQ	NADH-quinone oxidoreductase, chain M
TO73_1589	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TO73_1591	ENOG4107QM5	aconitate hydratase
TO73_1592	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TO73_1593	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
TO73_1594	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TO73_1595	ENOG410704R	Produces ATP from ADP in the presence of a proton gradient across the membrane
TO73_1596	ENOG41089ID	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TO73_1599	ENOG4105EBX	v-type atpase
TO73_1607	ENOG4105DR4	Methyltransferase
TO73_1611	ENOG4105E8R	UPF0173 metal-dependent hydrolase
TO73_1612	ENOG4105D9P	serine threonine protein kinase
TO73_1613	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TO73_1615	ENOG4105CJR	Integral membrane protein (MviN
TO73_1619	ENOG4108KGH	TRANSCRIPTIONal
TO73_1622	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
TO73_1626	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
TO73_1627	ENOG4105E0C	molybdate abc transporter
TO73_1628	ENOG4108UCS	ABC, transporter
TO73_1630	ENOG4105CUT	histidyl-tRNA synthetase
TO73_1631	ENOG4105C9M	aspartyl-trna synthetase
TO73_1632	ENOG4107ZY0	Phenazine biosynthesis-like protein
TO73_1633	ENOG410667J	hydrolase
TO73_1634	ENOG4105C5S	asparaginyl-tRNA synthetase
TO73_1635	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
TO73_1642	ENOG4105CGD	Nad-dependent epimerase dehydratase
TO73_1643	ENOG4105EWK	phytoene
TO73_1647	ENOG4105DRC	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity)
TO73_1649	ENOG4107YCR	Transcriptional regulator, ARSR family
TO73_1650	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
TO73_1652	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
TO73_1653	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
TO73_1654	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TO73_1656	ENOG4105DC7	peptidase M24
TO73_1658	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
TO73_1660	ENOG4108Z4T	Peptidase M50
TO73_1662	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
TO73_1673	ENOG4105CEC	DNA methylase N-4 N-6
TO73_1676	ENOG4107T65	Integrase
TO73_1680	ENOG4105CE9	30S ribosomal protein S2
TO73_1681	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
TO73_1682	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TO73_1683	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
TO73_1684	ENOG4105KNE	Phosphatidate cytidylyltransferase
TO73_1685	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
TO73_1686	ENOG4105DZP	Membrane-associated zinc metalloprotease
TO73_1689	ENOG4105II7	pyrroline-5-carboxylate reductase
TO73_1690	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TO73_1691	ENOG4105MCT	stage V sporulation protein S
TO73_1695	ENOG4105I7S	Abortive infection protein
TO73_1696	ENOG4105CYN	Serine protein kinase
TO73_1698	ENOG4105ED1	spovr family
TO73_1699	ENOG4107QXG	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TO73_1700	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
TO73_1704	ENOG41082J7	Rhodanese domain protein
TO73_1708	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
TO73_1709	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
TO73_1710	ENOG4105C1Q	protoporphyrinogen oxidase
TO73_1711	ENOG4106TD9	Diguanylate cyclase
TO73_1713	ENOG4105BZU	Histidine kinase
TO73_1714	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TO73_1716	ENOG4107QR7	peptidase S8 and S53, subtilisin, kexin, sedolisin
TO73_1717	ENOG4105KXX	peptidase s58 dmpa
TO73_1719	ENOG4107WTH	Galactitol-1-phosphate dehydrogenase
TO73_1720	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TO73_1723	ENOG4105MS2	ribosomal subunit Interface protein
TO73_1724	ENOG4105CAK	Cell division ATP-binding protein ftsE
TO73_1725	ENOG4105CN1	protease
TO73_1727	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TO73_1732	ENOG4105E66	phosphoriboisomerase A
TO73_1733	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TO73_1735	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
TO73_1736	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
TO73_1737	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TO73_1738	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
TO73_1741	ENOG4107ZQN	disulfide bond
TO73_1742	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
TO73_1744	ENOG4105CNU	cell division protein FtsK
TO73_1747	ENOG4105W87	Cbs domain
TO73_1748	ENOG4105CQC	Prephenate dehydratase
TO73_1749	ENOG4108KXV	response regulator
TO73_1754	ENOG4108JQ9	ABC transporter
TO73_1755	ENOG4105DIH	basic membrane
TO73_1757	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
TO73_1758	ENOG4105CDY	transcriptional regulatory protein
TO73_1759	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
TO73_1760	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TO73_1764	ENOG4108I5C	dEAD DEAH box helicase
TO73_1766	ENOG4105F8J	Adenylate Guanylate cyclase
TO73_1767	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
TO73_1768	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TO73_1769	ENOG4105CFH	Aspartokinase
TO73_1770	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
TO73_1771	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TO73_1774	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
TO73_1775	ENOG4105DTN	riboflavin biosynthesis protein ribF
TO73_1776	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TO73_1777	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TO73_1778	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
TO73_1779	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
TO73_1782	ENOG4107R1I	NAD-dependent malic enzyme
TO73_1783	ENOG4105VG1	fes assembly suf system protein
TO73_1784	ENOG4107TS3	membrane protein, TerC
TO73_1787	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TO73_1788	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
TO73_1790	ENOG4105C34	Pseudouridine synthase
TO73_1791	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
TO73_1792	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TO73_1796	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
TO73_1798	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
TO73_1801	ENOG4105CPF	Cell wall formation (By similarity)
TO73_1802	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
TO73_1803	ENOG4107UH2	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
TO73_1804	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TO73_1805	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
TO73_1806	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TO73_1808	ENOG41067KJ	GYD family
TO73_1809	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
TO73_1814	ENOG4105CJ1	ABC, transporter
TO73_1815	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TO73_1816	ENOG4107QX3	carboxylase
TO73_1822	ENOG4105WD1	Membrane
TO73_1825	ENOG4108FWV	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
TO73_1827	ENOG4105CQB	FAD linked oxidase domain protein
TO73_1828	ENOG4105CQB	FAD linked oxidase domain protein
TO73_1829	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
TO73_1835	ENOG4105CSA	Coproporphyrinogen iii oxidase
TO73_1836	ENOG4106YGA	NADH dehydrogenase (quinone)
TO73_1847	ENOG4105D6E	homoserine dehydrogenase
TO73_1848	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
TO73_1850	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
TO73_1853	ENOG41089UC	methyltransferase, type 11
TO73_1854	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TO73_1855	ENOG4105CG3	alpha amylase, catalytic region
TO73_1857	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TO73_1858	ENOG4106C07	ThiamineS Protein
TO73_1859	ENOG4105DGU	Histone deacetylase
TO73_1860	ENOG41080XP	Cbs domain
TO73_1862	ENOG4105C3U	ABC transporter
TO73_1863	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TO73_1865	ENOG4107QRA	Extracellular solute-binding protein, family 5
TO73_1867	ENOG4105CAY	ferredoxin--nadp reductase
TO73_1874	ENOG4108Z7R	Chaperone CsaA
TO73_1878	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
TO73_1884	ENOG4105CKK	Glycosyl transferase, family 2
TO73_1886	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TO73_1887	ENOG4105BZU	Histidine kinase
TO73_1893	ENOG4105CV1	Transketolase (EC 2.2.1.1)
TO73_1897	ENOG4105C1J	atp-dependent rna helicase
TO73_1898	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TO73_1902	ENOG4108JEI	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)
TO73_1904	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
TO73_1905	ENOG4105E3H	phosphoglycerate mutase
TO73_1907	ENOG4105SFS	phosphoesterase RecJ domain protein
TO73_1920	ENOG4108FYC	transcriptional regulator MERR family
TO73_1921	ENOG4105DVC	DnaJ domain protein
TO73_1922	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TO73_1923	ENOG4105CFG	Acts as a chaperone (By similarity)
TO73_1924	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TO73_1925	ENOG4105K70	DNA-binding protein
TO73_1927	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
TO73_1929	ENOG4105DG6	mannose-6-phosphate isomerase
TO73_1930	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
TO73_1931	ENOG4105CAT	Cytidine monophosphate kinase
TO73_1933	ENOG4108RJ7	Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity)
TO73_1934	ENOG4105CHR	reductase
TO73_1940	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TO73_1945	ENOG4105K63	Thioredoxin
TO73_1949	ENOG4105NCW	Trka-c domain protein
TO73_1950	ENOG4107S91	Sodium hydrogen exchanger
TO73_1956	ENOG4105CDU	Replicative dna helicase
TO73_1958	ENOG4105CBC	glutamate synthase
TO73_1961	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TO73_1964	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TO73_1965	ENOG4105BZU	Histidine kinase
TO73_1966	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
TO73_1968	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
TO73_1975	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
TO73_1977	ENOG4107QPV	Serine Threonine protein kinase
TO73_1978	ENOG4105KME	endoribonuclease L-psp
TO73_1983	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
TO73_1984	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TO73_1985	ENOG4105D1H	recombination factor protein RarA
TO73_1988	ENOG4105DHP	deoxycytidine triphosphate deaminase
TO73_1990	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
TO73_1991	ENOG4107ZZY	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
TO73_1992	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
TO73_1995	ENOG4105CM2	brancheD-chain amino acid aminotransferase
TO73_1996	ENOG4105DND	Transcriptional regulator
TO73_1997	ENOG4105WEF	catalase
TO73_1999	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
TO73_2000	ENOG4108UW5	maltose o-acetyltransferase
TO73_2001	ENOG4105D06	uba thif-type nad fad binding protein
TO73_2002	ENOG4105BZN	citrate synthase
TO73_2003	ENOG4105DR4	Methyltransferase
TO73_2004	ENOG4105D07	Signal peptide peptidase, SppA
TO73_2016	ENOG4105DP4	dak2 domain fusion protein ylov
TO73_2018	ENOG4105DCF	alanine dehydrogenase
TO73_2019	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TO73_2020	ENOG41060WC	Enoyl-CoA hydratase
TO73_2021	ENOG4105FE9	pseudouridine synthase
TO73_2022	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
TO73_2025	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TO73_2027	ENOG4107QYG	anthranilate phosphoribosyltransferase
TO73_2028	ENOG4105DDQ	anthranilate synthase
TO73_2029	ENOG4105CRQ	synthase (Component I)
TO73_2030	ENOG4105C26	Dehydrogenase
TO73_2031	ENOG41062BK	proline dehydrogenase
TO73_2035	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TO73_2036	ENOG4105XEZ	This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the
TO73_2038	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TO73_2039	ENOG4105CQ7	ATP-dependent helicase
TO73_2042	ENOG4105E2A	Dehydrogenase
TO73_2053	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
TO73_2054	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TO73_2055	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
TO73_2056	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
TO73_2057	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TO73_2060	ENOG4105DCF	alanine dehydrogenase
TO73_2061	ENOG4105CYC	Transferase
TO73_2062	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TO73_2063	ENOG41073R8	VanW family
TO73_2064	ENOG4105I08	Pseudouridine synthase
TO73_2067	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TO73_2068	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TO73_2071	ENOG410850P	UPF0102 protein
TO73_2072	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TO73_2073	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TO73_2075	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
TO73_2076	ENOG4105C87	Aminotransferase class I and II
TO73_2079	ENOG4105C5X	domain protein
TO73_2081	ENOG4108Z9K	Osmotically inducible protein
TO73_2082	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TO73_2083	ENOG4107QKW	extracellular solute-binding protein family 1
TO73_2085	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TO73_2086	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TO73_2087	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TO73_2089	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
TO73_2090	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
TO73_2092	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TO73_2095	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
TO73_2097	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
TO73_2098	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
TO73_2099	ENOG4108URH	decarboxylase
TO73_2100	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TO73_2103	ENOG4105D56	permease protein
TO73_2104	ENOG4105EG2	ABC transporter, permease
TO73_2105	ENOG4107R28	alpha amylase, catalytic region
TO73_2107	ENOG4105C98	muts2 protein
TO73_2112	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TO73_2113	ENOG4105UIB	(ABC) transporter
TO73_2132	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TO73_2134	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
TO73_2138	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
TO73_2142	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
TO73_2148	ENOG4105CJ1	ABC, transporter
TO73_2154	ENOG4105DXN	mazG family
TO73_2157	ENOG4107RRU	Involved in both the arginine and lysine biosynthetic pathways (By similarity)
TO73_2159	ENOG4105C6E	dna polymerase iii
TO73_2160	ENOG4105VPX	protein, conserved in bacteria
TO73_2162	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TO73_2163	ENOG4105DQU	oxidoreductase, subunit beta
TO73_2164	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TO73_2169	ENOG4108ZF3	Phosphatase
TO73_2170	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TO73_2173	ENOG4105KRF	dihydroneopterin aldolase
TO73_2174	ENOG4105EEI	dihydropteroate synthase
TO73_2178	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TO73_2179	ENOG4105CH5	extracellular solute-binding protein, family 7
TO73_2181	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TO73_2183	ENOG4108J2R	molybdopterin oxidoreductase
TO73_2185	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TO73_2186	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TO73_2187	ENOG4105F4P	)-transporter
TO73_2190	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
TO73_2191	ENOG4105CHM	Aminotransferase
TO73_2192	ENOG4105CPN	adenine deaminase
TO73_2195	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
TO73_2197	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TO73_2199	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
TO73_2200	ENOG4107QSN	dihydrolipoamide acetyltransferase
TO73_2201	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
TO73_2202	ENOG4108KB2	LysR family Transcriptional regulator
TO73_2205	ENOG4105G5W	regulator Fur family
TO73_2206	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
TO73_2207	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TO73_2209	ENOG4105C8U	phosphate abc transporter
TO73_2211	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
TO73_2213	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TO73_2228	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TO73_2236	ENOG4105BZ9	Cytochrome C oxidase, subunit I
TO73_2237	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
TO73_2238	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
TO73_2239	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
TO73_2240	ENOG4105C89	phosphohexose isomerase
TO73_2243	ENOG4108XAN	ABC transporter
TO73_2249	ENOG4105C22	threonyL-tRNA synthetase
TO73_2254	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
TO73_2256	ENOG4107EUI	c reductase, iron-sulfur
TO73_2257	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
TO73_2258	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
TO73_2268	ENOG4105PW4	Sugar fermentation stimulation protein homolog
TO73_2276	ENOG4105EVD	ribosomal RNA large subunit methyltransferase N
TO73_2277	ENOG41074MP	UPF0103 Mediator of ErbB2-driven cell motility-containing protein
TO73_2279	ENOG4105U0R	haloacid dehalogenase-like hydrolase
TO73_2282	ENOG41081QV	Universal stress protein
TO73_2284	ENOG4108KB0	deacetylase
TO73_2286	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
TO73_2288	ENOG4105EUJ	GTP cyclohydrolase i
TO73_2290	ENOG41062IR	nudix hydrolase
TO73_2294	ENOG4105D1H	recombination factor protein RarA
TO73_2295	ENOG4105DRS	transport system, permease
TO73_2296	ENOG4105VXP	Protein of unknown function DUF86
TO73_2298	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
TO73_2301	ENOG4105C7S	Dehydrogenase
TO73_2302	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TO73_2303	ENOG4105ZU5	s-layer protein
TO73_2304	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TO73_2305	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TO73_2316	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
TO73_2317	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
TO73_2319	ENOG4105C8B	TIGR00159 family
TO73_2320	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
TO73_2327	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
TO73_2330	ENOG4105DA2	glyoxalase bleomycin resistance protein dioxygenase
TO73_2331	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
TO73_2332	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TO73_2334	ENOG4105C02	permease
TO73_2336	ENOG4106633	50S ribosomal protein l28
TO73_2337	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
TO73_2338	ENOG4105CHM	Aminotransferase
TO73_2339	ENOG4105CBD	Diacylglycerol kinase
TO73_2341	ENOG4108DQ3	n-acetylglutamate synthase
TO73_2342	ENOG4105DGU	Histone deacetylase
TO73_2344	ENOG4105CB5	ATP-dependent DNA helicase recG
TO73_2345	ENOG4105BZU	Histidine kinase
TO73_2348	ENOG4108ZAF	Molybdopterin
TO73_2351	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
TO73_2352	ENOG4105C1G	acyl-Coa dehydrogenase
TO73_2354	ENOG4105C8T	Leucyl-tRNA synthetase
TO73_2357	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
TO73_2358	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TO73_2362	ENOG4108WBT	adenosyltransferase
TO73_2364	ENOG4108IUW	ABC transporter
TO73_2370	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
TO73_2371	ENOG4105CHW	UPF0052 protein
TO73_2374	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
TO73_2375	ENOG4105C25	Primosomal protein n'
TO73_2378	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
TO73_2379	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
TO73_2381	ENOG4105CTQ	phosphohexokinase
TO73_2384	ENOG4105F0N	pyrophosphate phospho-hydrolase
TO73_2388	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
TO73_2389	ENOG4105FA0	parb-like partition protein
TO73_2390	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
TO73_2391	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
TO73_2392	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TO73_2402	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TO73_2403	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TO73_2407	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TO73_2410	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TO73_2411	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
TO73_2418	ENOG4105CJ1	ABC, transporter
TO73_2604	ENOG4105WH1	Two component transcriptional regulator luxr family
TO73_2710	ENOG4105ZU5	s-layer protein
TO73_2711	ENOG4105CD2	stage iii sporulation protein aa
TO73_2743	ENOG4105FA0	parb-like partition protein
TO73_2744	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
TO73_2745	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TO73_2770	ENOG4108UUM	single-stranded DNA-binding protein
TO73_2791	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TO73_2809	ENOG4105D5G	Transposase
TO73_2817	ENOG4105C9U	ATP-dependent DNA helicase RecQ
TO73_2827	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
TO73_2828	ENOG4105EHG	Permease protein
TO73_2829	ENOG4107R4I	Periplasmic binding protein
TO73_2835	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TO73_2874	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
TO73_2875	ENOG4105FA0	parb-like partition protein
TO73_2876	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)