locus-tag	class	description
TO73_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TO73_0003	COG0148	phosphopyruvate hydratase activity
TO73_0004	COG0469	pyruvate kinase activity
TO73_0005	COG2010	Cytochrome c
TO73_0007	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_0008	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TO73_0011	COG1842	Phage shock protein A
TO73_0013	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TO73_0015	COG1278	Cold shock
TO73_0016	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TO73_0022	COG2860	membrane
TO73_0023	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TO73_0029	COG0459	protein refolding
TO73_0030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TO73_0031	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TO73_0035	COG1653	transport
TO73_0040	COG0033	Phosphoglucomutase
TO73_0044	COG0477	Major facilitator Superfamily
TO73_0046	COG0517	IMP dehydrogenase activity
TO73_0046	COG0516	GMP reductase activity
TO73_0047	COG1950	PFAM Membrane protein of
TO73_0055	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TO73_0056	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TO73_0058	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TO73_0059	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TO73_0062	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TO73_0063	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TO73_0064	COG1993	acr, cog1993
TO73_0065	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TO73_0067	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TO73_0069	COG1335	isochorismatase
TO73_0070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TO73_0071	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TO73_0071	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TO73_0081	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TO73_0082	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TO73_0083	COG0250	Participates in transcription elongation, termination and antitermination
TO73_0084	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TO73_0085	COG0081	regulation of translation
TO73_0086	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TO73_0087	COG0222	ribosome binding
TO73_0088	COG0163	prenyltransferase activity
TO73_0089	COG1960	acyl-CoA dehydrogenase activity
TO73_0090	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TO73_0093	COG1598	PFAM Uncharacterised protein family UPF0150
TO73_0094	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TO73_0095	COG0066	3-isopropylmalate dehydratase activity
TO73_0098	COG0189	ligase activity
TO73_0099	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TO73_0100	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TO73_0101	COG1543	Belongs to the glycosyl hydrolase 57 family
TO73_0102	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TO73_0102	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TO73_0103	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TO73_0104	COG1832	CoA-binding protein
TO73_0108	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TO73_0111	COG1388	LysM domain
TO73_0111	COG3942	CHAP domain
TO73_0113	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TO73_0115	COG1694	Mazg nucleotide pyrophosphohydrolase
TO73_0116	COG1363	Peptidase, m42
TO73_0117	COG1803	Methylglyoxal synthase
TO73_0119	COG2271	Major facilitator Superfamily
TO73_0122	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TO73_0123	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TO73_0124	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TO73_0126	COG0360	Binds together with S18 to 16S ribosomal RNA
TO73_0128	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TO73_0129	COG0359	binds to the 23S rRNA
TO73_0131	COG0300	oxidoreductase activity
TO73_0132	COG0321	lipoyl(octanoyl) transferase activity
TO73_0133	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TO73_0136	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TO73_0138	COG1598	PFAM Uncharacterised protein family UPF0150
TO73_0139	COG0022	dehydrogenase e1 component
TO73_0140	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TO73_0141	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TO73_0146	COG0432	Pfam Uncharacterised protein family UPF0047
TO73_0147	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TO73_0149	COG0668	transmembrane transport
TO73_0152	COG0632	four-way junction helicase activity
TO73_0153	COG1024	Enoyl-CoA hydratase
TO73_0155	COG0508	dehydrogenase complex catalyzes the overall conversion of
TO73_0156	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TO73_0157	COG1404	Belongs to the peptidase S8 family
TO73_0159	COG0137	argininosuccinate synthase activity
TO73_0160	COG0165	Argininosuccinate lyase
TO73_0164	COG0505	Belongs to the CarA family
TO73_0165	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TO73_0170	COG0582	viral genome integration into host DNA
TO73_0172	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TO73_0178	COG0210	DNA helicase
TO73_0214	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TO73_0215	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TO73_0216	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TO73_0217	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TO73_0220	COG0799	negative regulation of ribosome biogenesis
TO73_0222	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TO73_0227	COG0739	heme binding
TO73_0229	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TO73_0230	COG0825	malonyl-CoA metabolic process
TO73_0235	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TO73_0237	COG1278	Cold shock
TO73_0238	COG0484	heat shock protein binding
TO73_0239	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TO73_0240	COG1968	undecaprenyl-diphosphatase activity
TO73_0241	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TO73_0242	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TO73_0245	COG1309	transcriptional regulator
TO73_0246	COG4242	Belongs to the peptidase S51 family
TO73_0247	COG2389	metal-binding protein
TO73_0253	COG0437	4 iron, 4 sulfur cluster binding
TO73_0258	COG3706	GGDEF domain
TO73_0259	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TO73_0260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TO73_0263	COG0438	transferase activity, transferring glycosyl groups
TO73_0266	COG1185	polyribonucleotide nucleotidyltransferase activity
TO73_0268	COG0416	fatty acid biosynthetic process
TO73_0269	COG1371	PFAM Archease protein family (DUF101 UPF0211)
TO73_0270	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TO73_0274	COG0284	orotidine-5'-phosphate decarboxylase activity
TO73_0275	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TO73_0277	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TO73_0281	COG0822	iron-sulfur transferase activity
TO73_0282	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TO73_0291	COG0719	Fe-S assembly protein
TO73_0292	COG0719	Fe-S assembly protein
TO73_0293	COG0396	ATPase activity
TO73_0296	COG0446	pyridine nucleotide-disulphide oxidoreductase
TO73_0298	COG4181	ATPase activity
TO73_0299	COG1136	(ABC) transporter
TO73_0299	COG0577	efflux transmembrane transporter activity
TO73_0301	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TO73_0303	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TO73_0305	COG1175	transmembrane transport
TO73_0316	COG1058	Belongs to the CinA family
TO73_0316	COG1546	Belongs to the CinA family
TO73_0317	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TO73_0319	COG1418	mRNA catabolic process
TO73_0319	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TO73_0320	COG1077	Cell shape determining protein MreB Mrl
TO73_0321	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TO73_0325	COG0235	Class ii aldolase
TO73_0330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TO73_0332	COG1607	acyl-coa hydrolase
TO73_0333	COG2154	pterin-4-alpha-carbinolamine dehydratase
TO73_0336	COG0277	FAD linked oxidase domain protein
TO73_0343	COG0535	radical SAM domain protein
TO73_0347	COG0667	Aldo Keto reductase
TO73_0351	COG1067	ATP-dependent peptidase activity
TO73_0352	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TO73_0354	COG0745	RESPONSE REGULATOR receiver
TO73_0356	COG0297	glycogen (starch) synthase activity
TO73_0357	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TO73_0358	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TO73_0361	COG0142	geranyltranstransferase activity
TO73_0363	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TO73_0371	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TO73_0372	COG0049	tRNA binding
TO73_0373	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TO73_0375	COG0051	transcription antitermination factor activity, RNA binding
TO73_0376	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TO73_0377	COG0088	Forms part of the polypeptide exit tunnel
TO73_0378	COG0089	rRNA binding
TO73_0379	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TO73_0380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TO73_0381	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TO73_0382	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TO73_0383	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TO73_0384	COG0255	Belongs to the universal ribosomal protein uL29 family
TO73_0392	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TO73_0393	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TO73_0394	COG1841	ribosomal large subunit assembly
TO73_0395	COG0200	Binds to the 23S rRNA
TO73_0396	COG0201	protein transport
TO73_0397	COG0563	adenylate kinase activity
TO73_0399	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TO73_0400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TO73_0401	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TO73_0402	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TO73_0403	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TO73_0405	COG0203	ribosomal protein L17
TO73_0407	COG0697	spore germination
TO73_0415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TO73_0416	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TO73_0422	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TO73_0424	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TO73_0425	COG2385	sporulation resulting in formation of a cellular spore
TO73_0426	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TO73_0428	COG0194	GDP metabolic process
TO73_0430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TO73_0431	COG1438	arginine binding
TO73_0432	COG2095	MarC family integral membrane protein
TO73_0434	COG0497	DNA recombination
TO73_0437	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TO73_0440	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TO73_0442	COG0047	phosphoribosylformylglycinamidine synthase activity
TO73_0444	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TO73_0447	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TO73_0452	COG0546	phosphoglycolate phosphatase activity
TO73_0455	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TO73_0462	COG5002	protein histidine kinase activity
TO73_0462	COG3850	Histidine kinase
TO73_0465	COG0574	Belongs to the PEP-utilizing enzyme family
TO73_0465	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TO73_0466	COG0714	Associated with various cellular activities
TO73_0467	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TO73_0468	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TO73_0470	COG0483	inositol monophosphate 1-phosphatase activity
TO73_0471	COG0135	phosphoribosylanthranilate isomerase activity
TO73_0472	COG1372	Participates in initiation and elongation during chromosome replication
TO73_0472	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TO73_0473	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TO73_0474	COG0537	adenosine 5'-monophosphoramidase activity
TO73_0476	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TO73_0479	COG0546	phosphoglycolate phosphatase activity
TO73_0480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TO73_0484	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TO73_0485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TO73_0486	COG0823	Involved in the tonB-independent uptake of proteins
TO73_0486	COG1506	peptidase
TO73_0486	COG4946	Tricorn protease homolog
TO73_0491	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TO73_0492	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TO73_0493	COG0113	porphobilinogen synthase activity
TO73_0496	COG0631	protein serine/threonine phosphatase activity
TO73_0497	COG0515	serine threonine protein kinase
TO73_0497	COG2815	serine threonine protein kinase
TO73_0503	COG0210	DNA helicase
TO73_0504	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TO73_0505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TO73_0506	COG0504	CTP synthase activity
TO73_0511	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TO73_0512	COG2010	Cytochrome c
TO73_0516	COG2010	Cytochrome c
TO73_0517	COG3258	Cytochrome c
TO73_0520	COG0446	pyridine nucleotide-disulphide oxidoreductase
TO73_0521	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TO73_0523	COG0785	Cytochrome C biogenesis protein
TO73_0524	COG4133	protoheme IX ABC transporter activity
TO73_0526	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TO73_0527	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TO73_0528	COG1138	Cytochrome C-type biogenesis protein
TO73_0529	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TO73_0530	COG3088	subunit of a heme lyase
TO73_0532	COG0723	plastoquinol--plastocyanin reductase activity
TO73_0534	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TO73_0536	COG0268	Binds directly to 16S ribosomal RNA
TO73_0538	COG0083	homoserine kinase activity
TO73_0541	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TO73_0541	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TO73_0542	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TO73_0546	COG1160	GTP binding
TO73_0549	COG0736	holo-[acyl-carrier-protein] synthase activity
TO73_0550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TO73_0550	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TO73_0551	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TO73_0552	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TO73_0553	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TO73_0559	COG0473	3-isopropylmalate dehydrogenase activity
TO73_0567	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TO73_0569	COG0860	N-Acetylmuramoyl-L-alanine amidase
TO73_0571	COG1752	Esterase of the alpha-beta hydrolase superfamily
TO73_0573	COG1556	Lactate utilization protein
TO73_0575	COG0247	lactate metabolic process
TO73_0577	COG2205	protein histidine kinase activity
TO73_0581	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TO73_0584	COG1324	tolerance protein
TO73_0585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TO73_0586	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TO73_0587	COG0741	lytic transglycosylase activity
TO73_0587	COG0739	heme binding
TO73_0587	COG1196	nuclear chromosome segregation
TO73_0588	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TO73_0589	COG2197	response regulator
TO73_0592	COG1132	(ABC) transporter
TO73_0593	COG1132	(ABC) transporter
TO73_0594	COG0285	dihydrofolate synthase activity
TO73_0596	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TO73_0597	COG0601	transmembrane transport
TO73_0598	COG0747	negative chemotaxis
TO73_0599	COG0410	ABC transporter
TO73_0602	COG0559	Belongs to the binding-protein-dependent transport system permease family
TO73_0604	COG0174	glutamine synthetase
TO73_0605	COG0737	Belongs to the 5'-nucleotidase family
TO73_0607	COG2010	Cytochrome c
TO73_0611	COG0788	formyltetrahydrofolate deformylase activity
TO73_0615	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TO73_0619	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TO73_0621	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TO73_0622	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TO73_0628	COG1414	Transcriptional regulator
TO73_0629	COG0789	Transcriptional regulator
TO73_0630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TO73_0631	COG2045	Belongs to the ComB family
TO73_0632	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TO73_0633	COG1136	(ABC) transporter
TO73_0634	COG0813	purine-nucleoside phosphorylase activity
TO73_0635	COG1024	Enoyl-CoA hydratase
TO73_0640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_0641	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_0644	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TO73_0648	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TO73_0651	COG2890	protein-(glutamine-N5) methyltransferase activity
TO73_0652	COG1837	Belongs to the UPF0109 family
TO73_0653	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TO73_0657	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_0663	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TO73_0664	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TO73_0665	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TO73_0680	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TO73_0682	COG1760	l-serine dehydratase
TO73_0684	COG0481	GTPase activity
TO73_0685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TO73_0685	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TO73_0687	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TO73_0689	COG0195	Participates in both transcription termination and antitermination
TO73_0690	COG0779	Required for maturation of 30S ribosomal subunits
TO73_0693	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TO73_0693	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TO73_0695	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TO73_0695	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TO73_0699	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_0699	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TO73_0701	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TO73_0702	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TO73_0705	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TO73_0706	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TO73_0707	COG1702	phosphate starvation-inducible protein PhoH
TO73_0707	COG1702	phosphate starvation-inducible protein PhoH
TO73_0709	COG4864	UPF0365 protein
TO73_0711	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TO73_0714	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_0715	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TO73_0716	COG0824	Thioesterase
TO73_0718	COG0557	exoribonuclease II activity
TO73_0719	COG1355	regulation of microtubule-based process
TO73_0721	COG0237	dephospho-CoA kinase activity
TO73_0724	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_0725	COG0165	Argininosuccinate lyase
TO73_0729	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TO73_0730	COG2239	Acts as a magnesium transporter
TO73_0732	COG0589	response to stress
TO73_0733	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TO73_0734	COG1185	polyribonucleotide nucleotidyltransferase activity
TO73_0735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TO73_0738	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TO73_0739	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TO73_0741	COG1100	Small GTP-binding protein
TO73_0744	COG0010	Belongs to the arginase family
TO73_0748	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TO73_0749	COG0511	ligase activity, forming carbon-carbon bonds
TO73_0750	COG0439	Biotin carboxylase
TO73_0752	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TO73_0753	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TO73_0754	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TO73_0756	COG2181	nitrate reductase activity
TO73_0756	COG0247	lactate metabolic process
TO73_0758	COG2819	hydrolase of the alpha beta superfamily
TO73_0762	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TO73_0773	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TO73_0775	COG0438	transferase activity, transferring glycosyl groups
TO73_0779	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TO73_0780	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TO73_0782	COG1482	cell wall glycoprotein biosynthetic process
TO73_0783	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_0784	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TO73_0784	COG0662	Cupin 2, conserved barrel domain protein
TO73_0788	COG0438	transferase activity, transferring glycosyl groups
TO73_0792	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TO73_0794	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TO73_0795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TO73_0804	COG0582	viral genome integration into host DNA
TO73_0807	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TO73_0831	COG0183	Belongs to the thiolase family
TO73_0837	COG1129	ABC transporter
TO73_0842	COG0494	nUDIX hydrolase
TO73_0844	COG0138	bifunctional purine biosynthesis protein purh
TO73_0845	COG3239	Fatty acid desaturase
TO73_0846	COG1490	D-aminoacyl-tRNA deacylase activity
TO73_0847	COG1307	EDD domain protein, DegV family
TO73_0848	COG1307	EDD domain protein, DegV family
TO73_0851	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TO73_0853	COG0019	diaminopimelate decarboxylase activity
TO73_0854	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TO73_0857	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TO73_0858	COG1492	cobalamin metabolic process
TO73_0861	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TO73_0862	COG1980	fructose-bisphosphate aldolase activity
TO73_0864	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TO73_0865	COG0588	phosphoglycerate mutase activity
TO73_0867	COG0393	Putative heavy-metal-binding
TO73_0868	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TO73_0871	COG1797	cobyrinic acid a,c-diamide synthase activity
TO73_0872	COG2046	Belongs to the sulfate adenylyltransferase family
TO73_0873	COG1648	precorrin-2 dehydrogenase activity
TO73_0873	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TO73_0874	COG0730	response to heat
TO73_0875	COG0175	sulfate reduction
TO73_0876	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TO73_0876	COG1648	precorrin-2 dehydrogenase activity
TO73_0877	COG1587	Uroporphyrinogen-III synthase
TO73_0878	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TO73_0881	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TO73_0882	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TO73_0883	COG4558	Periplasmic binding protein
TO73_0884	COG0352	thiamine-phosphate diphosphorylase activity
TO73_0885	COG2104	thiamine diphosphate biosynthetic process
TO73_0886	COG2022	thiamine diphosphate biosynthetic process
TO73_0887	COG2022	thiamine diphosphate biosynthetic process
TO73_0887	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TO73_0888	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TO73_0889	COG0351	phosphomethylpyrimidine kinase
TO73_0891	COG0395	ABC-type sugar transport system, permease component
TO73_0898	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TO73_0900	COG3328	transposase activity
TO73_0907	COG0588	phosphoglycerate mutase activity
TO73_0909	COG0411	ABC transporter
TO73_0910	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_0912	COG0559	Belongs to the binding-protein-dependent transport system permease family
TO73_0921	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_0923	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_0924	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_0928	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TO73_0929	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_0930	COG2267	carboxylic ester hydrolase activity
TO73_0932	COG2030	dehydratase
TO73_0934	COG0559	Belongs to the binding-protein-dependent transport system permease family
TO73_0937	COG0410	ABC transporter
TO73_0938	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_0939	COG2062	phosphohistidine phosphatase, SixA
TO73_0945	COG0395	ABC-type sugar transport system, permease component
TO73_0946	COG1175	transmembrane transport
TO73_0950	COG1785	Belongs to the alkaline phosphatase family
TO73_0951	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TO73_0953	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TO73_0956	COG0683	leucine binding
TO73_0968	COG1309	transcriptional regulator
TO73_0969	COG1960	acyl-CoA dehydrogenase activity
TO73_0970	COG2030	dehydratase
TO73_0970	COG1012	belongs to the aldehyde dehydrogenase family
TO73_0971	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_0972	COG2193	ferroxidase activity
TO73_0973	COG1733	regulation of RNA biosynthetic process
TO73_0974	COG4974	Belongs to the 'phage' integrase family
TO73_0978	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TO73_0985	COG1518	maintenance of DNA repeat elements
TO73_0987	COG3396	Phenylacetate-CoA oxygenase
TO73_0991	COG1012	belongs to the aldehyde dehydrogenase family
TO73_0991	COG2030	dehydratase
TO73_0994	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TO73_0995	COG2050	protein possibly involved in aromatic compounds catabolism
TO73_0996	COG0410	ABC transporter
TO73_0997	COG0411	ABC transporter
TO73_1001	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TO73_1002	COG2368	4-hydroxyphenylacetate
TO73_1003	COG1012	belongs to the aldehyde dehydrogenase family
TO73_1005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TO73_1007	COG1648	precorrin-2 dehydrogenase activity
TO73_1007	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TO73_1016	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TO73_1017	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TO73_1018	COG0183	Belongs to the thiolase family
TO73_1019	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TO73_1020	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TO73_1024	COG1331	Highly conserved protein containing a thioredoxin domain
TO73_1025	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TO73_1026	COG1960	acyl-CoA dehydrogenase activity
TO73_1027	COG2414	aldehyde ferredoxin oxidoreductase
TO73_1031	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TO73_1036	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TO73_1039	COG3383	formate dehydrogenase (NAD+) activity
TO73_1040	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TO73_1041	COG0745	RESPONSE REGULATOR receiver
TO73_1042	COG5002	protein histidine kinase activity
TO73_1043	COG1960	acyl-CoA dehydrogenase activity
TO73_1044	COG2086	electron transfer activity
TO73_1045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TO73_1047	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TO73_1048	COG1573	uracil-dna glycosylase
TO73_1049	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TO73_1049	COG1796	DNA polymerase
TO73_1053	COG2873	o-acetylhomoserine
TO73_1055	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TO73_1056	COG1116	anion transmembrane transporter activity
TO73_1056	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TO73_1057	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TO73_1058	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TO73_1059	COG0215	cysteine-tRNA ligase activity
TO73_1060	COG1960	acyl-CoA dehydrogenase activity
TO73_1061	COG0183	Belongs to the thiolase family
TO73_1062	COG1250	3-hydroxyacyl-CoA dehydrogenase
TO73_1062	COG1024	Enoyl-CoA hydratase
TO73_1064	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TO73_1066	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TO73_1069	COG1216	Glycosyl transferase, family 2
TO73_107	COG0445	tRNA wobble uridine modification
TO73_1071	COG0726	polysaccharide deacetylase
TO73_1072	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TO73_1072	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TO73_1073	COG1811	Na channel or pump
TO73_1074	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TO73_1075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TO73_1076	COG4948	Mandelate Racemase Muconate Lactonizing
TO73_1078	COG0402	S-adenosylhomocysteine deaminase activity
TO73_1084	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TO73_1085	COG0742	ribosomal rna small subunit methyltransferase
TO73_1090	COG2873	o-acetylhomoserine
TO73_1091	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TO73_1092	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TO73_1094	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TO73_1098	COG0149	triose-phosphate isomerase activity
TO73_1100	COG0126	phosphoglycerate kinase activity
TO73_1102	COG1268	BioY protein
TO73_1105	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TO73_1108	COG1196	nuclear chromosome segregation
TO73_1111	COG2738	Putative neutral zinc metallopeptidase
TO73_1113	COG2897	thiosulfate sulfurtransferase activity
TO73_1114	COG1760	l-serine dehydratase
TO73_1115	COG2197	response regulator
TO73_1116	COG0335	large ribosomal subunit rRNA binding
TO73_1117	COG0336	Belongs to the RNA methyltransferase TrmD family
TO73_1118	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TO73_1122	COG2239	Acts as a magnesium transporter
TO73_1124	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TO73_1127	COG1692	metallophosphoesterase
TO73_1130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TO73_1132	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TO73_1134	COG1410	methionine synthase
TO73_1134	COG0646	methionine synthase
TO73_1135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TO73_1136	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TO73_1137	COG0740	serine-type endopeptidase activity
TO73_1138	COG0544	peptidyl-prolyl cis-trans isomerase activity
TO73_1144	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TO73_1145	COG3870	Protein conserved in bacteria
TO73_1147	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TO73_1149	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TO73_1151	COG4475	Protein of unknown function (DUF436)
TO73_1154	COG1970	mechanosensitive ion channel activity
TO73_1155	COG3842	ATPase activity
TO73_1159	COG2176	DNA-directed DNA polymerase activity
TO73_1160	COG0154	amidase activity
TO73_1161	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TO73_1163	COG1435	thymidine kinase activity
TO73_1164	COG0254	rRNA binding
TO73_1212	COG5005	Phage virion morphogenesis
TO73_1220	COG2001	Belongs to the MraZ family
TO73_1221	COG0275	rRNA processing
TO73_1226	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TO73_1227	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TO73_1228	COG0772	Belongs to the SEDS family
TO73_1229	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TO73_1230	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TO73_1231	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TO73_1235	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TO73_1236	COG2197	response regulator
TO73_1244	COG2391	methyltransferase activity
TO73_1245	COG1090	epimerase
TO73_1246	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TO73_1248	COG1562	ergosterol biosynthetic process
TO73_1249	COG0415	Belongs to the DNA photolyase family
TO73_1256	COG1304	FMN binding
TO73_1264	COG1321	iron dependent repressor
TO73_1268	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TO73_1269	COG1120	ATPase activity
TO73_1280	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TO73_1282	COG0489	protein tyrosine kinase activity
TO73_1285	COG0525	valine-tRNA ligase activity
TO73_1287	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TO73_1289	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TO73_1290	COG0134	indole-3-glycerol-phosphate synthase activity
TO73_1291	COG1752	Esterase of the alpha-beta hydrolase superfamily
TO73_1295	COG0765	amino acid transport
TO73_1296	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TO73_1298	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TO73_1299	COG0569	domain protein
TO73_1300	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TO73_1302	COG2313	pseudouridylate synthase activity
TO73_1305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TO73_1307	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TO73_1308	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TO73_1312	COG0012	GTP binding
TO73_1313	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TO73_1315	COG0424	maF-like protein
TO73_1318	COG0768	penicillin binding
TO73_1320	COG2322	membrane
TO73_1324	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TO73_1325	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TO73_1327	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TO73_1329	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_1335	COG1131	(ABC) transporter
TO73_1338	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TO73_1341	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TO73_1342	COG0440	acetolactate synthase activity
TO73_1343	COG0028	Belongs to the TPP enzyme family
TO73_1344	COG0492	ferredoxin-NADP+ reductase activity
TO73_1345	COG0861	Integral membrane protein TerC family
TO73_1348	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TO73_1349	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_1351	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TO73_1352	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TO73_1353	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TO73_1354	COG1024	Enoyl-CoA hydratase
TO73_1355	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TO73_1355	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TO73_1359	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TO73_1362	COG0423	glycine-tRNA ligase activity
TO73_1363	COG0542	response to heat
TO73_1364	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TO73_1365	COG4956	integral membrane protein (PIN domain superfamily)
TO73_1370	COG1250	3-hydroxyacyl-CoA dehydrogenase
TO73_1371	COG0697	spore germination
TO73_1372	COG0612	Peptidase, M16
TO73_1373	COG0612	Peptidase, M16
TO73_1374	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TO73_1379	COG1337	RAMP superfamily
TO73_1388	COG0419	ATPase involved in DNA repair
TO73_1389	COG0420	3'-5' exonuclease activity
TO73_1395	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TO73_1396	COG2133	pyrroloquinoline quinone binding
TO73_1398	COG1063	alcohol dehydrogenase
TO73_1400	COG1254	Belongs to the acylphosphatase family
TO73_1401	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TO73_1404	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TO73_1405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TO73_1410	COG0183	Belongs to the thiolase family
TO73_1412	COG4968	Prepilin-type N-terminal cleavage methylation domain
TO73_1419	COG4636	protein conserved in cyanobacteria
TO73_1424	COG0180	Tryptophanyl-tRNA synthetase
TO73_1427	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TO73_1428	COG0066	3-isopropylmalate dehydratase activity
TO73_1433	COG0129	dihydroxy-acid dehydratase activity
TO73_1434	COG2010	Cytochrome c
TO73_1436	COG1177	transmembrane transport
TO73_1437	COG1176	ABC-type spermidine putrescine transport system, permease component I
TO73_1438	COG3842	ATPase activity
TO73_1439	COG0772	Belongs to the SEDS family
TO73_1440	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TO73_1441	COG2894	cell division
TO73_1442	COG1733	regulation of RNA biosynthetic process
TO73_1446	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_1447	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_1448	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_1450	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TO73_1454	COG2205	protein histidine kinase activity
TO73_1455	COG0745	RESPONSE REGULATOR receiver
TO73_1456	COG2176	DNA-directed DNA polymerase activity
TO73_1456	COG5002	protein histidine kinase activity
TO73_1457	COG0151	Belongs to the GarS family
TO73_1458	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TO73_1459	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_1460	COG0179	Fumarylacetoacetate (FAA) hydrolase
TO73_1461	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TO73_1465	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TO73_1466	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TO73_1469	COG2514	catechol 2,3-dioxygenase activity
TO73_1470	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TO73_1471	COG0287	Prephenate dehydrogenase
TO73_1472	COG3706	GGDEF domain
TO73_1472	COG0745	RESPONSE REGULATOR receiver
TO73_1473	COG0277	FAD linked oxidase domain protein
TO73_1479	COG0009	L-threonylcarbamoyladenylate synthase
TO73_1480	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TO73_1482	COG0456	acetyltransferase
TO73_1482	COG0454	-acetyltransferase
TO73_1483	COG1960	acyl-CoA dehydrogenase activity
TO73_1485	COG0312	modulator of DNA gyrase
TO73_1486	COG0312	modulator of DNA gyrase
TO73_1488	COG0730	response to heat
TO73_1491	COG0540	Belongs to the ATCase OTCase family
TO73_1492	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TO73_1494	COG0167	dihydroorotate dehydrogenase activity
TO73_1496	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TO73_1497	COG0746	molybdenum cofactor guanylyltransferase activity
TO73_1500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TO73_1505	COG0473	3-isopropylmalate dehydrogenase activity
TO73_1506	COG0557	exoribonuclease II activity
TO73_1509	COG0585	pseudouridine synthase activity
TO73_1511	COG2050	protein possibly involved in aromatic compounds catabolism
TO73_1512	COG0322	excinuclease ABC activity
TO73_1514	COG0018	arginyl-trna synthetase
TO73_1515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TO73_1516	COG1428	Deoxynucleoside kinase
TO73_1517	COG1428	Deoxynucleoside kinase
TO73_1518	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TO73_1519	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TO73_1521	COG0107	imidazoleglycerol-phosphate synthase activity
TO73_1522	COG0140	phosphoribosyl-ATP diphosphatase activity
TO73_1522	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TO73_1524	COG1494	fructose-1,6-bisphosphatase
TO73_1531	COG0084	hydrolase, TatD family'
TO73_1534	COG0017	Asparaginyl-tRNA synthetase
TO73_1535	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TO73_1536	COG1053	succinate dehydrogenase
TO73_1538	COG2009	succinate dehydrogenase
TO73_1539	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TO73_1545	COG0318	PFAM AMP-dependent synthetase and ligase
TO73_1546	COG1104	cysteine desulfurase activity
TO73_1547	COG1959	2 iron, 2 sulfur cluster binding
TO73_1548	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TO73_1549	COG1121	(ABC) transporter
TO73_1550	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TO73_1551	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TO73_1552	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TO73_1553	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TO73_1554	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TO73_1555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TO73_1556	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TO73_1557	COG0131	Imidazoleglycerol-phosphate dehydratase
TO73_1558	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TO73_1573	COG4712	double-strand break repair protein
TO73_1575	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TO73_1576	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_1577	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_1578	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_1579	COG0649	NAD binding
TO73_1580	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TO73_1581	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TO73_1582	COG1034	ATP synthesis coupled electron transport
TO73_1583	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TO73_1584	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_1585	COG0839	Belongs to the complex I subunit 6 family
TO73_1586	COG0713	ATP synthesis coupled electron transport
TO73_1587	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TO73_1588	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TO73_1589	COG1007	ATP synthesis coupled electron transport
TO73_1591	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TO73_1592	COG1394	ATPase activity, coupled to movement of substances
TO73_1593	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TO73_1594	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TO73_1595	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TO73_1596	COG1527	subunit (C
TO73_1597	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TO73_1599	COG1269	ATP hydrolysis coupled proton transport
TO73_1607	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TO73_1611	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TO73_1612	COG0515	serine threonine protein kinase
TO73_1612	COG2815	serine threonine protein kinase
TO73_1613	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TO73_1615	COG0728	peptidoglycan biosynthetic process
TO73_1619	COG1316	TRANSCRIPTIONal
TO73_1622	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TO73_1628	COG3842	ATPase activity
TO73_1630	COG0124	histidyl-tRNA synthetase
TO73_1631	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TO73_1632	COG0384	phenazine biosynthesis protein PhzF
TO73_1633	COG0561	phosphatase activity
TO73_1634	COG0017	Asparaginyl-tRNA synthetase
TO73_1635	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TO73_1642	COG0702	epimerase
TO73_1643	COG1233	COG1233 Phytoene dehydrogenase and related
TO73_1647	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TO73_1649	COG0640	Transcriptional regulator
TO73_1650	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TO73_1652	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TO73_1653	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TO73_1654	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TO73_1655	COG4636	protein conserved in cyanobacteria
TO73_1656	COG0006	proline dipeptidase activity
TO73_1657	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TO73_1658	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TO73_1660	COG1994	Peptidase M50
TO73_1662	COG0617	tRNA 3'-terminal CCA addition
TO73_1673	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TO73_1680	COG0052	Belongs to the universal ribosomal protein uS2 family
TO73_1681	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TO73_1682	COG0528	UMP kinase activity
TO73_1683	COG0233	cytoplasmic translational termination
TO73_1684	COG4589	Belongs to the CDS family
TO73_1685	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TO73_1686	COG0750	zinc metalloprotease
TO73_1689	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TO73_1690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TO73_1691	COG2359	stage V sporulation protein S
TO73_1693	COG2137	regulation of response to DNA damage stimulus
TO73_1695	COG1266	CAAX protease self-immunity
TO73_1696	COG2766	serine protein kinase
TO73_1698	COG2719	SpoVR family
TO73_1699	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TO73_1700	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TO73_1704	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TO73_1708	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TO73_1709	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TO73_1711	COG3706	GGDEF domain
TO73_1715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TO73_1717	COG3191	aminopeptidase activity
TO73_1719	COG1063	alcohol dehydrogenase
TO73_1720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TO73_1723	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TO73_1724	COG2884	Cell division ATP-binding protein ftsE
TO73_1725	COG0793	Belongs to the peptidase S41A family
TO73_1727	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TO73_1727	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TO73_1732	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TO73_1733	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TO73_1735	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TO73_1736	COG0159	tryptophan synthase activity
TO73_1737	COG0133	tryptophan synthase activity
TO73_1738	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TO73_1741	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TO73_1742	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TO73_1744	COG1674	ftsk spoiiie
TO73_1747	COG0517	IMP dehydrogenase activity
TO73_1748	COG0077	Prephenate dehydratase
TO73_1748	COG1605	Chorismate mutase
TO73_1749	COG0745	RESPONSE REGULATOR receiver
TO73_1755	COG1744	ABC transporter substrate-binding protein PnrA-like
TO73_1757	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TO73_1757	COG4651	solute:proton antiporter activity
TO73_1758	COG0217	transcriptional regulatory protein
TO73_1759	COG0653	protein targeting
TO73_1760	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TO73_1764	COG1111	helicase
TO73_1764	COG1205	dead DEAH box helicase
TO73_1767	COG0358	DNA primase activity
TO73_1768	COG0039	L-malate dehydrogenase activity
TO73_1770	COG2813	Specifically methylates the guanine in position
TO73_1774	COG0494	nUDIX hydrolase
TO73_1775	COG0196	riboflavin kinase activity
TO73_1776	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TO73_1777	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TO73_1778	COG0509	glycine decarboxylation via glycine cleavage system
TO73_1779	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TO73_1782	COG0281	malic enzyme
TO73_1783	COG2151	metal-sulfur cluster biosynthetic enzyme
TO73_1784	COG0861	Integral membrane protein TerC family
TO73_1790	COG0564	pseudouridine synthase activity
TO73_1791	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TO73_1792	COG2255	four-way junction helicase activity
TO73_1796	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TO73_1798	COG1085	galactose-1-phosphate uridylyltransferase
TO73_1801	COG1181	Belongs to the D-alanine--D-alanine ligase family
TO73_1802	COG0193	aminoacyl-tRNA hydrolase activity
TO73_1803	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TO73_1804	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TO73_1805	COG1854	S-ribosylhomocysteine lyase activity
TO73_1806	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TO73_1806	COG0519	Catalyzes the synthesis of GMP from XMP
TO73_1807	COG4636	protein conserved in cyanobacteria
TO73_1808	COG4274	PFAM GYD family protein
TO73_1809	COG0346	lactoylglutathione lyase activity
TO73_1814	COG1131	(ABC) transporter
TO73_1815	COG0328	RNA-DNA hybrid ribonuclease activity
TO73_1816	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TO73_1822	COG2832	Protein of unknown function (DUF454)
TO73_1825	COG0037	tRNA processing
TO73_1825	COG0590	tRNA wobble adenosine to inosine editing
TO73_1827	COG0277	FAD linked oxidase domain protein
TO73_1828	COG0277	FAD linked oxidase domain protein
TO73_1829	COG0247	lactate metabolic process
TO73_1835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TO73_1845	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TO73_1847	COG0460	homoserine dehydrogenase
TO73_1848	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TO73_1850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TO73_1853	COG2226	methyltransferase
TO73_1854	COG2226	methyltransferase
TO73_1855	COG0366	Alpha amylase catalytic
TO73_1857	COG0037	tRNA processing
TO73_1858	COG2104	thiamine diphosphate biosynthetic process
TO73_1859	COG0123	including yeast histone deacetylase and acetoin utilization protein
TO73_1860	COG0517	IMP dehydrogenase activity
TO73_1862	COG0444	Belongs to the ABC transporter superfamily
TO73_1863	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TO73_1864	COG0601	transmembrane transport
TO73_1865	COG0747	negative chemotaxis
TO73_1867	COG0492	ferredoxin-NADP+ reductase activity
TO73_1874	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TO73_1875	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TO73_1878	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TO73_1882	COG2070	2-Nitropropane dioxygenase
TO73_1884	COG0463	Glycosyl transferase, family 2
TO73_1886	COG0745	RESPONSE REGULATOR receiver
TO73_1887	COG5002	protein histidine kinase activity
TO73_1891	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TO73_1893	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TO73_1897	COG0513	Belongs to the DEAD box helicase family
TO73_1898	COG0303	'Molybdopterin
TO73_1902	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TO73_1904	COG0442	prolyl-tRNA aminoacylation
TO73_1905	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TO73_1907	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TO73_1920	COG0789	Transcriptional regulator
TO73_1921	COG0484	heat shock protein binding
TO73_1922	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TO73_1923	COG0443	Heat shock 70 kDa protein
TO73_1924	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TO73_1925	COG0776	regulation of translation
TO73_1927	COG1515	deoxyribonuclease V activity
TO73_1929	COG1482	cell wall glycoprotein biosynthetic process
TO73_1930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TO73_1931	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TO73_1933	COG1051	belongs to the nudix hydrolase family
TO73_1934	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_1940	COG0542	response to heat
TO73_1945	COG3118	belongs to the thioredoxin family
TO73_1949	COG0490	domain, Protein
TO73_1950	COG0475	glutathione-regulated potassium exporter activity
TO73_1953	COG4109	DRTGG domain
TO73_1954	COG0475	glutathione-regulated potassium exporter activity
TO73_1956	COG0305	Participates in initiation and elongation during chromosome replication
TO73_1958	COG0070	glutamate synthase
TO73_1958	COG0067	glutamate synthase
TO73_1958	COG0069	glutamate synthase activity
TO73_1961	COG0517	IMP dehydrogenase activity
TO73_1961	COG0516	GMP reductase activity
TO73_1965	COG2205	protein histidine kinase activity
TO73_1966	COG0704	Plays a role in the regulation of phosphate uptake
TO73_1968	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TO73_1972	COG3335	DDE superfamily endonuclease
TO73_1975	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TO73_1977	COG0515	serine threonine protein kinase
TO73_1977	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TO73_1983	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TO73_1984	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_1985	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TO73_1985	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TO73_1988	COG0717	Belongs to the dCTP deaminase family
TO73_1990	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TO73_1991	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TO73_1992	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TO73_1996	COG0583	DNA-binding transcription factor activity
TO73_1997	COG3546	catalase activity
TO73_1998	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TO73_1998	COG0758	DNA mediated transformation
TO73_1999	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TO73_2001	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TO73_2002	COG0372	Belongs to the citrate synthase family
TO73_2003	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TO73_2004	COG0616	signal peptide processing
TO73_2016	COG1461	Dihydroxyacetone kinase
TO73_2018	COG0686	Belongs to the AlaDH PNT family
TO73_2019	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TO73_2020	COG1024	Enoyl-CoA hydratase
TO73_2021	COG1187	pseudouridine synthase activity
TO73_2025	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TO73_2026	COG4636	protein conserved in cyanobacteria
TO73_2027	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TO73_2028	COG0512	Glutamine amidotransferase of anthranilate synthase
TO73_2029	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TO73_2030	COG1012	belongs to the aldehyde dehydrogenase family
TO73_2031	COG0506	proline dehydrogenase activity
TO73_2035	COG0156	8-amino-7-oxononanoate synthase activity
TO73_2038	COG0187	DNA topoisomerase II activity
TO73_2039	COG1643	Atp-dependent helicase
TO73_2042	COG1063	alcohol dehydrogenase
TO73_2053	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TO73_2053	COG1605	Chorismate mutase
TO73_2054	COG0805	protein transport
TO73_2055	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TO73_2056	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TO73_2057	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TO73_2060	COG0686	Belongs to the AlaDH PNT family
TO73_2061	COG0427	acetyl-CoA hydrolase
TO73_2062	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TO73_2063	COG2720	vancomycin resistance protein
TO73_2064	COG1187	pseudouridine synthase activity
TO73_2067	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TO73_2068	COG1028	Short-chain dehydrogenase reductase Sdr
TO73_2071	COG0792	nuclease activity
TO73_2072	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TO73_2075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TO73_2076	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TO73_2079	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TO73_2081	COG1764	response to oxidative stress
TO73_2082	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TO73_2085	COG3842	ATPase activity
TO73_2086	COG0101	tRNA pseudouridine synthase activity
TO73_2087	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TO73_2088	COG0601	transmembrane transport
TO73_2089	COG0747	negative chemotaxis
TO73_2090	COG0316	Belongs to the HesB IscA family
TO73_2092	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TO73_2095	COG1166	arginine decarboxylase activity
TO73_2097	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TO73_2098	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TO73_2099	COG1611	Belongs to the LOG family
TO73_2100	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TO73_2103	COG1175	transmembrane transport
TO73_2104	COG3833	ABC-type maltose transport systems, permease component
TO73_2105	COG0366	Alpha amylase catalytic
TO73_2107	COG1193	negative regulation of DNA recombination
TO73_2112	COG2226	methyltransferase
TO73_2132	COG2414	aldehyde ferredoxin oxidoreductase
TO73_2134	COG0604	alcohol dehydrogenase
TO73_2138	COG1902	pentaerythritol trinitrate reductase activity
TO73_2142	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TO73_2148	COG1131	(ABC) transporter
TO73_2154	COG3956	TIGRFAM MazG family protein
TO73_2157	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TO73_2159	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TO73_2160	COG1937	Protein conserved in bacteria
TO73_2162	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TO73_2162	COG0674	pyruvate-flavodoxin oxidoreductase activity
TO73_2163	COG1013	pyruvate-flavodoxin oxidoreductase activity
TO73_2164	COG0315	cyclic pyranopterin monophosphate synthase activity
TO73_2169	COG0631	protein serine/threonine phosphatase activity
TO73_2170	COG0105	UTP biosynthetic process
TO73_2173	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TO73_2179	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TO73_2181	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TO73_2183	COG0243	molybdopterin cofactor binding
TO73_2185	COG0301	tRNA thio-modification
TO73_2186	COG0154	amidase activity
TO73_2187	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TO73_2190	COG0521	Mo-molybdopterin cofactor biosynthetic process
TO73_2191	COG0436	Aminotransferase
TO73_2192	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TO73_2195	COG1404	Belongs to the peptidase S8 family
TO73_2197	COG0285	dihydrofolate synthase activity
TO73_2199	COG0181	hydroxymethylbilane synthase activity
TO73_2200	COG0508	dehydrogenase complex catalyzes the overall conversion of
TO73_2202	COG0583	DNA-binding transcription factor activity
TO73_2205	COG0735	belongs to the Fur family
TO73_2206	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TO73_2207	COG0482	sulfurtransferase activity
TO73_2208	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TO73_2209	COG0573	inorganic phosphate transmembrane transporter activity
TO73_2211	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TO73_2212	COG2814	Major facilitator Superfamily
TO73_2213	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TO73_2236	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TO73_2236	COG1845	cytochrome c oxidase, subunit III
TO73_2238	COG0109	protoheme IX farnesyltransferase activity
TO73_2238	COG1612	heme a metabolic process
TO73_2239	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TO73_2240	COG0166	Belongs to the GPI family
TO73_2249	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TO73_2256	COG0723	plastoquinol--plastocyanin reductase activity
TO73_2257	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TO73_2258	COG0539	negative regulation of cytoplasmic translation
TO73_2264	COG1115	amino acid carrier protein
TO73_2268	COG1489	DNA binding
TO73_2276	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TO73_2277	COG1355	regulation of microtubule-based process
TO73_2282	COG0589	response to stress
TO73_2283	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TO73_2284	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TO73_2288	COG0302	gtp cyclohydrolase
TO73_2294	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TO73_2295	COG0395	ABC-type sugar transport system, permease component
TO73_2296	COG2361	Protein of unknown function DUF86
TO73_2298	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TO73_2302	COG0556	nucleotide-excision repair
TO73_2303	COG0497	DNA recombination
TO73_2304	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TO73_2316	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TO73_2317	COG0242	peptide deformylase activity
TO73_2319	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TO73_2320	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TO73_2327	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TO73_2330	COG0346	lactoylglutathione lyase activity
TO73_2331	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TO73_2332	COG0343	queuine tRNA-ribosyltransferase activity
TO73_2334	COG0628	permease
TO73_2336	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TO73_2339	COG1597	lipid kinase activity
TO73_2341	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TO73_2341	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TO73_2342	COG0123	including yeast histone deacetylase and acetoin utilization protein
TO73_2345	COG0004	ammonium transporteR
TO73_2346	COG0347	Belongs to the P(II) protein family
TO73_2348	COG0314	molybdopterin synthase activity
TO73_2350	COG4636	protein conserved in cyanobacteria
TO73_2351	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TO73_2352	COG1960	acyl-CoA dehydrogenase activity
TO73_2354	COG0495	leucyl-tRNA aminoacylation
TO73_2357	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TO73_2358	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TO73_2362	COG2096	Adenosyltransferase
TO73_2364	COG4555	ABC transporter
TO73_2370	COG1660	Displays ATPase and GTPase activities
TO73_2371	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TO73_2374	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TO73_2375	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TO73_2378	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TO73_2379	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TO73_2379	COG0072	phenylalanine-tRNA ligase activity
TO73_2381	COG0205	6-phosphofructokinase activity
TO73_2382	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TO73_2384	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TO73_2388	COG0658	competence protein
TO73_2388	COG2333	competence protein COMEC
TO73_2389	COG1475	DNA binding
TO73_2390	COG1192	Involved in chromosome partitioning
TO73_2391	COG0357	Ribosomal RNA small subunit methyltransferase G
TO73_2392	COG0445	tRNA wobble uridine modification
TO73_2402	COG0706	membrane insertase activity
TO73_2403	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TO73_2403	COG0574	Belongs to the PEP-utilizing enzyme family
TO73_2407	COG2264	protein methyltransferase activity
TO73_2410	COG1573	uracil-dna glycosylase
TO73_2411	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TO73_2418	COG1131	(ABC) transporter
TO73_2604	COG2197	response regulator
TO73_2710	COG0497	DNA recombination
TO73_2711	COG3854	ATPases associated with a variety of cellular activities
TO73_2741	COG1525	nuclease
TO73_2743	COG1475	DNA binding
TO73_2744	COG1192	Involved in chromosome partitioning
TO73_2745	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TO73_2791	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TO73_2809	COG3328	transposase activity
TO73_2815	COG1487	ribonuclease activity
TO73_2827	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TO73_2828	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TO73_2829	COG4558	Periplasmic binding protein
TO73_2833	COG1607	acyl-coa hydrolase
TO73_2874	COG1192	Involved in chromosome partitioning
TO73_2875	COG1475	DNA binding
TO73_2876	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair