locus-tag	class	description
TbrSNM41_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TbrSNM41_00030	COG0148	phosphopyruvate hydratase activity
TbrSNM41_00040	COG0469	pyruvate kinase activity
TbrSNM41_00050	COG2010	Cytochrome c
TbrSNM41_00060	COG0535	radical SAM domain protein
TbrSNM41_00080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TbrSNM41_00090	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TbrSNM41_00110	COG1842	Phage shock protein A
TbrSNM41_00130	COG1131	(ABC) transporter
TbrSNM41_00140	COG0842	Transport permease protein
TbrSNM41_00170	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TbrSNM41_00180	COG1047	Peptidyl-prolyl cis-trans
TbrSNM41_00190	COG1278	Cold shock
TbrSNM41_00200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TbrSNM41_00240	COG2860	membrane
TbrSNM41_00250	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TbrSNM41_00300	COG0459	protein refolding
TbrSNM41_00310	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TbrSNM41_00320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TbrSNM41_00340	COG0166	Belongs to the GPI family
TbrSNM41_00350	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TbrSNM41_00360	COG1612	heme a metabolic process
TbrSNM41_00360	COG0109	protoheme IX farnesyltransferase activity
TbrSNM41_00370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TbrSNM41_00370	COG2010	Cytochrome c
TbrSNM41_00380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TbrSNM41_00380	COG1845	cytochrome c oxidase, subunit III
TbrSNM41_00420	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TbrSNM41_00430	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TbrSNM41_00460	COG0495	leucyl-tRNA aminoacylation
TbrSNM41_00480	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_00490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TbrSNM41_00530	COG0314	molybdopterin synthase activity
TbrSNM41_00540	COG1420	regulation of RNA biosynthetic process
TbrSNM41_00550	COG0347	Belongs to the P(II) protein family
TbrSNM41_00560	COG0004	ammonium transporteR
TbrSNM41_00580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TbrSNM41_00590	COG1126	abc transporter atp-binding protein
TbrSNM41_00640	COG1653	transport
TbrSNM41_00680	COG0033	Phosphoglucomutase
TbrSNM41_00690	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TbrSNM41_00720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TbrSNM41_00720	COG0517	IMP dehydrogenase activity
TbrSNM41_00730	COG1950	PFAM Membrane protein of
TbrSNM41_00740	COG0539	negative regulation of cytoplasmic translation
TbrSNM41_00750	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TbrSNM41_00760	COG0723	plastoquinol--plastocyanin reductase activity
TbrSNM41_00840	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TbrSNM41_00910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TbrSNM41_00950	COG1079	Belongs to the binding-protein-dependent transport system permease family
TbrSNM41_00960	COG4603	Belongs to the binding-protein-dependent transport system permease family
TbrSNM41_00970	COG2226	methyltransferase
TbrSNM41_00980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TbrSNM41_01020	COG1193	negative regulation of DNA recombination
TbrSNM41_01040	COG0366	Alpha amylase catalytic
TbrSNM41_01090	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TbrSNM41_01100	COG1611	Belongs to the LOG family
TbrSNM41_01110	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TbrSNM41_01120	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TbrSNM41_01130	COG3706	GGDEF domain
TbrSNM41_01140	COG1166	arginine decarboxylase activity
TbrSNM41_01170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TbrSNM41_01200	COG1067	ATP-dependent peptidase activity
TbrSNM41_01210	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TbrSNM41_01230	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_01250	COG0297	glycogen (starch) synthase activity
TbrSNM41_01270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TbrSNM41_01280	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TbrSNM41_01310	COG0142	geranyltranstransferase activity
TbrSNM41_01320	COG0697	spore germination
TbrSNM41_01330	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TbrSNM41_01380	COG0315	cyclic pyranopterin monophosphate synthase activity
TbrSNM41_01410	COG0674	pyruvate-flavodoxin oxidoreductase activity
TbrSNM41_01410	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TbrSNM41_01430	COG1937	Protein conserved in bacteria
TbrSNM41_01440	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TbrSNM41_01460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TbrSNM41_01470	COG0693	protein deglycase activity
TbrSNM41_01480	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TbrSNM41_01490	COG3956	TIGRFAM MazG family protein
TbrSNM41_01550	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TbrSNM41_01580	COG1902	pentaerythritol trinitrate reductase activity
TbrSNM41_01620	COG2414	aldehyde ferredoxin oxidoreductase
TbrSNM41_01650	COG0123	including yeast histone deacetylase and acetoin utilization protein
TbrSNM41_01700	COG3547	Transposase (IS116 IS110 IS902 family)
TbrSNM41_01770	COG1597	lipid kinase activity
TbrSNM41_01780	COG0436	Aminotransferase
TbrSNM41_01790	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TbrSNM41_01800	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TbrSNM41_01820	COG0628	permease
TbrSNM41_01840	COG0343	queuine tRNA-ribosyltransferase activity
TbrSNM41_01850	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TbrSNM41_01860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TbrSNM41_01910	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TbrSNM41_01920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TbrSNM41_01950	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TbrSNM41_02000	COG2199	diguanylate cyclase activity
TbrSNM41_02000	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TbrSNM41_02010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TbrSNM41_02020	COG0497	DNA recombination
TbrSNM41_02030	COG0556	nucleotide-excision repair
TbrSNM41_02060	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TbrSNM41_02070	COG0359	binds to the 23S rRNA
TbrSNM41_02090	COG0300	oxidoreductase activity
TbrSNM41_02100	COG0321	lipoyl(octanoyl) transferase activity
TbrSNM41_02110	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TbrSNM41_02140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TbrSNM41_02160	COG0022	dehydrogenase e1 component
TbrSNM41_02170	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TbrSNM41_02180	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TbrSNM41_02230	COG2226	methyltransferase
TbrSNM41_02250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TbrSNM41_02270	COG0668	transmembrane transport
TbrSNM41_02280	COG0316	Belongs to the HesB IscA family
TbrSNM41_02300	COG0601	transmembrane transport
TbrSNM41_02310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TbrSNM41_02320	COG0101	tRNA pseudouridine synthase activity
TbrSNM41_02330	COG3842	ATPase activity
TbrSNM41_02360	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TbrSNM41_02370	COG1764	response to oxidative stress
TbrSNM41_02390	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TbrSNM41_02410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TbrSNM41_02430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TbrSNM41_02440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TbrSNM41_02470	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TbrSNM41_02480	COG0792	nuclease activity
TbrSNM41_02500	COG0492	ferredoxin-NADP+ reductase activity
TbrSNM41_02510	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TbrSNM41_02520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TbrSNM41_02550	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TbrSNM41_02560	COG0066	3-isopropylmalate dehydratase activity
TbrSNM41_02590	COG0189	ligase activity
TbrSNM41_02600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TbrSNM41_02610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TbrSNM41_02620	COG1543	Belongs to the glycosyl hydrolase 57 family
TbrSNM41_02630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TbrSNM41_02630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TbrSNM41_02640	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TbrSNM41_02680	COG0445	tRNA wobble uridine modification
TbrSNM41_02690	COG1388	LysM domain
TbrSNM41_02690	COG0791	NLP P60 protein
TbrSNM41_02720	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TbrSNM41_02730	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TbrSNM41_02740	COG0477	Major facilitator Superfamily
TbrSNM41_02760	COG1131	(ABC) transporter
TbrSNM41_02780	COG1694	Mazg nucleotide pyrophosphohydrolase
TbrSNM41_02790	COG1803	Methylglyoxal synthase
TbrSNM41_02800	COG0606	chelatase, subunit chli
TbrSNM41_02860	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TbrSNM41_02910	COG1131	(ABC) transporter
TbrSNM41_02920	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TbrSNM41_02930	COG0395	ABC-type sugar transport system, permease component
TbrSNM41_02940	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TbrSNM41_02990	COG1217	gtp-binding protein TYPA
TbrSNM41_03030	COG0302	gtp cyclohydrolase
TbrSNM41_03070	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TbrSNM41_03080	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TbrSNM41_03090	COG0589	response to stress
TbrSNM41_03100	COG1611	Belongs to the LOG family
TbrSNM41_03120	COG1011	Hydrolase
TbrSNM41_03130	COG1355	regulation of microtubule-based process
TbrSNM41_03140	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TbrSNM41_03180	COG1489	DNA binding
TbrSNM41_03220	COG1115	amino acid carrier protein
TbrSNM41_03300	COG0546	phosphoglycolate phosphatase activity
TbrSNM41_03330	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TbrSNM41_03400	COG3850	Histidine kinase
TbrSNM41_03400	COG5002	protein histidine kinase activity
TbrSNM41_03420	COG1272	protein, Hemolysin III
TbrSNM41_03430	COG0574	Belongs to the PEP-utilizing enzyme family
TbrSNM41_03430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TbrSNM41_03440	COG0714	Associated with various cellular activities
TbrSNM41_03450	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TbrSNM41_03460	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TbrSNM41_03470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TbrSNM41_03490	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TbrSNM41_03510	COG1175	transmembrane transport
TbrSNM41_03580	COG1546	Belongs to the CinA family
TbrSNM41_03580	COG1058	Belongs to the CinA family
TbrSNM41_03590	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TbrSNM41_03610	COG1418	mRNA catabolic process
TbrSNM41_03610	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TbrSNM41_03620	COG1077	Cell shape determining protein MreB Mrl
TbrSNM41_03630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TbrSNM41_03660	COG0135	phosphoribosylanthranilate isomerase activity
TbrSNM41_03670	COG0483	inositol monophosphate 1-phosphatase activity
TbrSNM41_03690	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TbrSNM41_03710	COG1607	acyl-coa hydrolase
TbrSNM41_03720	COG2154	pterin-4-alpha-carbinolamine dehydratase
TbrSNM41_03730	COG3706	GGDEF domain
TbrSNM41_03740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TbrSNM41_03750	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TbrSNM41_03770	COG1185	polyribonucleotide nucleotidyltransferase activity
TbrSNM41_03780	COG3118	belongs to the thioredoxin family
TbrSNM41_03790	COG0416	fatty acid biosynthetic process
TbrSNM41_03810	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TbrSNM41_03820	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TbrSNM41_03860	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TbrSNM41_03880	COG0047	phosphoribosylformylglycinamidine synthase activity
TbrSNM41_03900	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TbrSNM41_03910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TbrSNM41_03920	COG0406	alpha-ribazole phosphatase activity
TbrSNM41_03930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TbrSNM41_03940	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TbrSNM41_03960	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TbrSNM41_03970	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TbrSNM41_03980	COG1496	oxidoreductase activity
TbrSNM41_04000	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TbrSNM41_04010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TbrSNM41_04020	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TbrSNM41_04030	COG1196	nuclear chromosome segregation
TbrSNM41_04030	COG0741	lytic transglycosylase activity
TbrSNM41_04030	COG0739	heme binding
TbrSNM41_04040	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TbrSNM41_04050	COG2197	response regulator
TbrSNM41_04080	COG1132	(ABC) transporter
TbrSNM41_04090	COG1132	(ABC) transporter
TbrSNM41_04100	COG0285	dihydrofolate synthase activity
TbrSNM41_04120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TbrSNM41_04130	COG0601	transmembrane transport
TbrSNM41_04140	COG0747	negative chemotaxis
TbrSNM41_04180	COG0559	Belongs to the binding-protein-dependent transport system permease family
TbrSNM41_04200	COG0174	glutamine synthetase
TbrSNM41_04210	COG0737	Belongs to the 5'-nucleotidase family
TbrSNM41_04250	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TbrSNM41_04260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TbrSNM41_04270	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TbrSNM41_04280	COG0788	formyltetrahydrofolate deformylase activity
TbrSNM41_04310	COG2358	TRAP transporter, solute receptor (TAXI family
TbrSNM41_04350	COG2814	Major facilitator Superfamily
TbrSNM41_04360	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TbrSNM41_04370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TbrSNM41_04380	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TbrSNM41_04430	COG0037	tRNA processing
TbrSNM41_04430	COG0590	tRNA wobble adenosine to inosine editing
TbrSNM41_04470	COG4966	pilus assembly protein PilW
TbrSNM41_04530	COG0604	alcohol dehydrogenase
TbrSNM41_04550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TbrSNM41_04560	COG0328	RNA-DNA hybrid ribonuclease activity
TbrSNM41_04590	COG0631	protein serine/threonine phosphatase activity
TbrSNM41_04600	COG0515	serine threonine protein kinase
TbrSNM41_04600	COG2815	serine threonine protein kinase
TbrSNM41_04620	COG2205	protein histidine kinase activity
TbrSNM41_04670	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TbrSNM41_04680	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TbrSNM41_04690	COG0504	CTP synthase activity
TbrSNM41_04760	COG3842	ATPase activity
TbrSNM41_04770	COG2010	Cytochrome c
TbrSNM41_04810	COG3258	Cytochrome c
TbrSNM41_04820	COG2010	Cytochrome c
TbrSNM41_04830	COG0737	Belongs to the 5'-nucleotidase family
TbrSNM41_04840	COG2010	Cytochrome c
TbrSNM41_04850	COG3258	Cytochrome c
TbrSNM41_04880	COG0446	pyridine nucleotide-disulphide oxidoreductase
TbrSNM41_04910	COG0785	Cytochrome C biogenesis protein
TbrSNM41_04930	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TbrSNM41_04940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TbrSNM41_04950	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TbrSNM41_04960	COG1138	Cytochrome C-type biogenesis protein
TbrSNM41_04970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TbrSNM41_04980	COG4235	cytochrome complex assembly
TbrSNM41_04980	COG3088	subunit of a heme lyase
TbrSNM41_04990	COG2010	Cytochrome c
TbrSNM41_05090	COG3547	Transposase (IS116 IS110 IS902 family)
TbrSNM41_05110	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TbrSNM41_05130	COG0268	Binds directly to 16S ribosomal RNA
TbrSNM41_05150	COG0083	homoserine kinase activity
TbrSNM41_05160	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TbrSNM41_05160	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TbrSNM41_05170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TbrSNM41_05190	COG4149	molybdate abc transporter
TbrSNM41_05230	COG0235	Class ii aldolase
TbrSNM41_05670	COG3335	DDE superfamily endonuclease
TbrSNM41_05680	COG1714	RDD family
TbrSNM41_05690	COG0616	signal peptide processing
TbrSNM41_05700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TbrSNM41_05710	COG0372	Belongs to the citrate synthase family
TbrSNM41_05720	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TbrSNM41_05740	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TbrSNM41_05750	COG0758	DNA mediated transformation
TbrSNM41_05750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TbrSNM41_05760	COG3546	catalase activity
TbrSNM41_05770	COG0583	DNA-binding transcription factor activity
TbrSNM41_05800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TbrSNM41_05810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TbrSNM41_05820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TbrSNM41_05840	COG0717	Belongs to the dCTP deaminase family
TbrSNM41_05880	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_05890	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TbrSNM41_05950	COG0515	serine threonine protein kinase
TbrSNM41_05950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TbrSNM41_05970	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TbrSNM41_05990	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TbrSNM41_06010	COG0704	Plays a role in the regulation of phosphate uptake
TbrSNM41_06020	COG2205	protein histidine kinase activity
TbrSNM41_06030	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_06060	COG0516	GMP reductase activity
TbrSNM41_06060	COG0517	IMP dehydrogenase activity
TbrSNM41_06090	COG0069	glutamate synthase activity
TbrSNM41_06090	COG0070	glutamate synthase
TbrSNM41_06090	COG0067	glutamate synthase
TbrSNM41_06100	COG0840	transmembrane signaling receptor activity
TbrSNM41_06110	COG0305	Participates in initiation and elongation during chromosome replication
TbrSNM41_06130	COG0475	glutathione-regulated potassium exporter activity
TbrSNM41_06140	COG0517	IMP dehydrogenase activity
TbrSNM41_06170	COG0475	glutathione-regulated potassium exporter activity
TbrSNM41_06180	COG0490	domain, Protein
TbrSNM41_06220	COG3118	belongs to the thioredoxin family
TbrSNM41_06270	COG0542	response to heat
TbrSNM41_06280	COG0789	Transcriptional regulator
TbrSNM41_06290	COG0484	heat shock protein binding
TbrSNM41_06300	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TbrSNM41_06310	COG0443	Heat shock 70 kDa protein
TbrSNM41_06320	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TbrSNM41_06330	COG0776	regulation of translation
TbrSNM41_06350	COG1515	deoxyribonuclease V activity
TbrSNM41_06370	COG1482	cell wall glycoprotein biosynthetic process
TbrSNM41_06390	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TbrSNM41_06400	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TbrSNM41_06410	COG1213	nucleotidyl transferase
TbrSNM41_06410	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TbrSNM41_06430	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_06440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TbrSNM41_06450	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TbrSNM41_06470	COG1494	fructose-1,6-bisphosphatase
TbrSNM41_06480	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TbrSNM41_06480	COG0140	phosphoribosyl-ATP diphosphatase activity
TbrSNM41_06490	COG0107	imidazoleglycerol-phosphate synthase activity
TbrSNM41_06500	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TbrSNM41_06510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TbrSNM41_06530	COG1428	Deoxynucleoside kinase
TbrSNM41_06550	COG0018	arginyl-trna synthetase
TbrSNM41_06570	COG0322	excinuclease ABC activity
TbrSNM41_06590	COG2050	protein possibly involved in aromatic compounds catabolism
TbrSNM41_06630	COG0585	pseudouridine synthase activity
TbrSNM41_06650	COG0557	exoribonuclease II activity
TbrSNM41_06660	COG0538	isocitrate dehydrogenase activity
TbrSNM41_06710	COG2165	general secretion pathway protein
TbrSNM41_06740	COG4970	Tfp pilus assembly protein FimT
TbrSNM41_06760	COG0183	Belongs to the thiolase family
TbrSNM41_06790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TbrSNM41_06800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TbrSNM41_06830	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TbrSNM41_06840	COG1254	Belongs to the acylphosphatase family
TbrSNM41_06880	COG1063	alcohol dehydrogenase
TbrSNM41_06890	COG2133	pyrroloquinoline quinone binding
TbrSNM41_06900	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TbrSNM41_06950	COG0517	IMP dehydrogenase activity
TbrSNM41_06960	COG0077	Prephenate dehydratase
TbrSNM41_06960	COG1605	Chorismate mutase
TbrSNM41_06970	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_07020	COG3845	ABC transporter
TbrSNM41_07030	COG1744	ABC transporter substrate-binding protein PnrA-like
TbrSNM41_07050	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TbrSNM41_07060	COG0133	tryptophan synthase activity
TbrSNM41_07070	COG0159	tryptophan synthase activity
TbrSNM41_07100	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TbrSNM41_07120	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TbrSNM41_07130	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TbrSNM41_07140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TbrSNM41_07140	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TbrSNM41_07160	COG0793	Belongs to the peptidase S41A family
TbrSNM41_07170	COG2884	Cell division ATP-binding protein ftsE
TbrSNM41_07180	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TbrSNM41_07210	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TbrSNM41_07260	COG0714	Associated with various cellular activities
TbrSNM41_07290	COG3191	aminopeptidase activity
TbrSNM41_07300	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TbrSNM41_07370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TbrSNM41_07400	COG2832	Protein of unknown function (DUF454)
TbrSNM41_07410	COG2132	Multicopper oxidase
TbrSNM41_07420	COG0535	radical SAM domain protein
TbrSNM41_07450	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TbrSNM41_07470	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TbrSNM41_07490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TbrSNM41_07520	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TbrSNM41_07550	COG2181	nitrate reductase activity
TbrSNM41_07630	COG2151	metal-sulfur cluster biosynthetic enzyme
TbrSNM41_07680	COG2199	diguanylate cyclase activity
TbrSNM41_07690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TbrSNM41_07700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TbrSNM41_07710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TbrSNM41_07750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TbrSNM41_07760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TbrSNM41_07780	COG1054	Belongs to the UPF0176 family
TbrSNM41_07790	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TbrSNM41_07800	COG2719	SpoVR family
TbrSNM41_07820	COG2766	serine protein kinase
TbrSNM41_07850	COG2137	regulation of response to DNA damage stimulus
TbrSNM41_07900	COG2359	stage V sporulation protein S
TbrSNM41_07910	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TbrSNM41_07920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TbrSNM41_07940	COG1216	Glycosyl transferase, family 2
TbrSNM41_07950	COG0750	zinc metalloprotease
TbrSNM41_07960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TbrSNM41_07970	COG4589	Belongs to the CDS family
TbrSNM41_07980	COG0233	cytoplasmic translational termination
TbrSNM41_07990	COG0528	UMP kinase activity
TbrSNM41_08000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TbrSNM41_08010	COG0052	Belongs to the universal ribosomal protein uS2 family
TbrSNM41_08030	COG3620	sequence-specific DNA binding
TbrSNM41_08030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TbrSNM41_08030	COG0617	tRNA 3'-terminal CCA addition
TbrSNM41_08050	COG1994	Peptidase M50
TbrSNM41_08070	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TbrSNM41_08080	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TbrSNM41_08090	COG0006	proline dipeptidase activity
TbrSNM41_08100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TbrSNM41_08110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TbrSNM41_08120	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TbrSNM41_08140	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TbrSNM41_08150	COG0640	Transcriptional regulator
TbrSNM41_08160	COG2217	Heavy metal translocating P-type atpase
TbrSNM41_08170	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TbrSNM41_08180	COG0017	Asparaginyl-tRNA synthetase
TbrSNM41_08190	COG0561	phosphatase activity
TbrSNM41_08200	COG0384	phenazine biosynthesis protein PhzF
TbrSNM41_08220	COG0124	histidyl-tRNA synthetase
TbrSNM41_08240	COG3842	ATPase activity
TbrSNM41_08270	COG1573	uracil-dna glycosylase
TbrSNM41_08310	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TbrSNM41_08360	COG0728	peptidoglycan biosynthetic process
TbrSNM41_08380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TbrSNM41_08400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TbrSNM41_08430	COG2414	aldehyde ferredoxin oxidoreductase
TbrSNM41_08450	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TbrSNM41_08470	COG1269	ATP hydrolysis coupled proton transport
TbrSNM41_08490	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TbrSNM41_08500	COG1527	subunit (C
TbrSNM41_08510	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TbrSNM41_08520	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TbrSNM41_08530	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TbrSNM41_08540	COG1394	ATPase activity, coupled to movement of substances
TbrSNM41_08550	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TbrSNM41_08580	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TbrSNM41_08660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TbrSNM41_08680	COG1760	l-serine dehydratase
TbrSNM41_08700	COG0481	GTPase activity
TbrSNM41_08750	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_08760	COG0183	Belongs to the thiolase family
TbrSNM41_08780	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TbrSNM41_08800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TbrSNM41_08860	COG1692	metallophosphoesterase
TbrSNM41_08890	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TbrSNM41_08910	COG2239	Acts as a magnesium transporter
TbrSNM41_08930	COG0228	four-way junction DNA binding
TbrSNM41_08950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TbrSNM41_08960	COG0336	Belongs to the RNA methyltransferase TrmD family
TbrSNM41_08970	COG0335	large ribosomal subunit rRNA binding
TbrSNM41_08980	COG2197	response regulator
TbrSNM41_08990	COG1760	l-serine dehydratase
TbrSNM41_09000	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_09010	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TbrSNM41_09010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TbrSNM41_09030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TbrSNM41_09050	COG0195	Participates in both transcription termination and antitermination
TbrSNM41_09060	COG0779	Required for maturation of 30S ribosomal subunits
TbrSNM41_09070	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TbrSNM41_09070	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TbrSNM41_09090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TbrSNM41_09090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TbrSNM41_09100	COG2304	oxidoreductase activity
TbrSNM41_09140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TbrSNM41_09140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TbrSNM41_09150	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TbrSNM41_09150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TbrSNM41_09160	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TbrSNM41_09200	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TbrSNM41_09210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TbrSNM41_09220	COG1702	phosphate starvation-inducible protein PhoH
TbrSNM41_09240	COG4864	UPF0365 protein
TbrSNM41_09260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TbrSNM41_09310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TbrSNM41_09340	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TbrSNM41_09350	COG0824	Thioesterase
TbrSNM41_09370	COG0557	exoribonuclease II activity
TbrSNM41_09380	COG1355	regulation of microtubule-based process
TbrSNM41_09390	COG0617	tRNA 3'-terminal CCA addition
TbrSNM41_09390	COG1353	crispr-associated protein
TbrSNM41_09400	COG0237	dephospho-CoA kinase activity
TbrSNM41_09410	COG4221	oxidoreductase activity
TbrSNM41_09430	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TbrSNM41_09500	COG0165	Argininosuccinate lyase
TbrSNM41_09530	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TbrSNM41_09540	COG2239	Acts as a magnesium transporter
TbrSNM41_09560	COG0589	response to stress
TbrSNM41_09570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TbrSNM41_09580	COG1185	polyribonucleotide nucleotidyltransferase activity
TbrSNM41_09590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TbrSNM41_09620	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TbrSNM41_09630	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TbrSNM41_09650	COG1100	Small GTP-binding protein
TbrSNM41_09680	COG0010	Belongs to the arginase family
TbrSNM41_09720	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TbrSNM41_09730	COG0511	ligase activity, forming carbon-carbon bonds
TbrSNM41_09740	COG0439	Biotin carboxylase
TbrSNM41_09760	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TbrSNM41_09770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TbrSNM41_09780	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TbrSNM41_09800	COG0247	lactate metabolic process
TbrSNM41_09800	COG2181	nitrate reductase activity
TbrSNM41_09820	COG0861	Integral membrane protein TerC family
TbrSNM41_09830	COG2819	hydrolase of the alpha beta superfamily
TbrSNM41_09850	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TbrSNM41_09860	COG0438	transferase activity, transferring glycosyl groups
TbrSNM41_09940	COG2244	polysaccharide biosynthetic process
TbrSNM41_09970	COG0438	transferase activity, transferring glycosyl groups
TbrSNM41_09990	COG0438	transferase activity, transferring glycosyl groups
TbrSNM41_10000	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TbrSNM41_10080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TbrSNM41_10090	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TbrSNM41_10110	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TbrSNM41_10120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TbrSNM41_10160	COG3845	ABC transporter
TbrSNM41_10170	COG4603	Belongs to the binding-protein-dependent transport system permease family
TbrSNM41_10180	COG1079	Belongs to the binding-protein-dependent transport system permease family
TbrSNM41_10200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TbrSNM41_10210	COG0494	nUDIX hydrolase
TbrSNM41_10230	COG0138	bifunctional purine biosynthesis protein purh
TbrSNM41_10240	COG3239	Fatty acid desaturase
TbrSNM41_10250	COG1490	D-aminoacyl-tRNA deacylase activity
TbrSNM41_10260	COG1307	EDD domain protein, DegV family
TbrSNM41_10270	COG1307	EDD domain protein, DegV family
TbrSNM41_10280	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TbrSNM41_10320	COG1136	(ABC) transporter
TbrSNM41_10360	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TbrSNM41_10380	COG1012	belongs to the aldehyde dehydrogenase family
TbrSNM41_10390	COG2368	4-hydroxyphenylacetate
TbrSNM41_10400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TbrSNM41_10470	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TbrSNM41_10520	COG0574	Belongs to the PEP-utilizing enzyme family
TbrSNM41_10520	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TbrSNM41_10540	COG1063	alcohol dehydrogenase
TbrSNM41_10570	COG3181	Tripartite tricarboxylate transporter family receptor
TbrSNM41_10600	COG3335	DDE superfamily endonuclease
TbrSNM41_10750	COG0411	ABC transporter
TbrSNM41_10770	COG0683	leucine binding
TbrSNM41_10810	COG1802	Transcriptional regulator
TbrSNM41_10830	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TbrSNM41_10840	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TbrSNM41_10860	COG4974	Belongs to the 'phage' integrase family
TbrSNM41_10870	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_10900	COG0318	PFAM AMP-dependent synthetase and ligase
TbrSNM41_10920	COG1012	belongs to the aldehyde dehydrogenase family
TbrSNM41_10920	COG2030	dehydratase
TbrSNM41_10930	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_10950	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_10960	COG1309	transcriptional regulator
TbrSNM41_11000	COG0318	PFAM AMP-dependent synthetase and ligase
TbrSNM41_11060	COG1309	transcriptional regulator
TbrSNM41_11070	COG3396	Phenylacetate-CoA oxygenase
TbrSNM41_11090	COG3396	Phenylacetate-CoA oxygenase
TbrSNM41_11110	COG1012	belongs to the aldehyde dehydrogenase family
TbrSNM41_11110	COG2030	dehydratase
TbrSNM41_11120	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_11150	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_11160	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TbrSNM41_11180	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TbrSNM41_11190	COG1414	Transcriptional regulator
TbrSNM41_11200	COG0800	Aldolase
TbrSNM41_11210	COG1980	fructose-bisphosphate aldolase activity
TbrSNM41_11220	COG1733	regulation of RNA biosynthetic process
TbrSNM41_11230	COG2193	ferroxidase activity
TbrSNM41_11240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TbrSNM41_11250	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TbrSNM41_11270	COG1331	Highly conserved protein containing a thioredoxin domain
TbrSNM41_11280	COG0183	Belongs to the thiolase family
TbrSNM41_11290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TbrSNM41_11300	COG0477	Major facilitator Superfamily
TbrSNM41_11320	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_11340	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TbrSNM41_11350	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
TbrSNM41_11360	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TbrSNM41_11370	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TbrSNM41_11390	COG3383	formate dehydrogenase (NAD+) activity
TbrSNM41_11400	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TbrSNM41_11410	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_11420	COG5002	protein histidine kinase activity
TbrSNM41_11430	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_11440	COG2086	electron transfer activity
TbrSNM41_11450	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TbrSNM41_11470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TbrSNM41_11480	COG2197	response regulator
TbrSNM41_11490	COG1573	uracil-dna glycosylase
TbrSNM41_11500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TbrSNM41_11500	COG1796	DNA polymerase
TbrSNM41_11530	COG0674	pyruvate-flavodoxin oxidoreductase activity
TbrSNM41_11530	COG1013	pyruvate-flavodoxin oxidoreductase activity
TbrSNM41_11530	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TbrSNM41_11530	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TbrSNM41_11550	COG2309	aminopeptidase activity
TbrSNM41_11560	COG2873	o-acetylhomoserine
TbrSNM41_11590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TbrSNM41_11600	COG0215	cysteine-tRNA ligase activity
TbrSNM41_11610	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_11620	COG0183	Belongs to the thiolase family
TbrSNM41_11640	COG1250	3-hydroxyacyl-CoA dehydrogenase
TbrSNM41_11640	COG1024	Enoyl-CoA hydratase
TbrSNM41_11660	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TbrSNM41_11700	COG1063	alcohol dehydrogenase
TbrSNM41_11720	COG1012	belongs to the aldehyde dehydrogenase family
TbrSNM41_11730	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TbrSNM41_11760	COG0438	transferase activity, transferring glycosyl groups
TbrSNM41_11770	COG0438	transferase activity, transferring glycosyl groups
TbrSNM41_11790	COG1215	transferase activity, transferring glycosyl groups
TbrSNM41_11820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TbrSNM41_11820	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TbrSNM41_11830	COG1811	Na channel or pump
TbrSNM41_11840	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TbrSNM41_11850	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TbrSNM41_11860	COG4948	Mandelate Racemase Muconate Lactonizing
TbrSNM41_11880	COG0402	S-adenosylhomocysteine deaminase activity
TbrSNM41_11890	COG0038	chloride channel
TbrSNM41_11940	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TbrSNM41_11950	COG0742	ribosomal rna small subunit methyltransferase
TbrSNM41_11970	COG2873	o-acetylhomoserine
TbrSNM41_11980	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TbrSNM41_11990	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TbrSNM41_12000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TbrSNM41_12040	COG0436	Aminotransferase
TbrSNM41_12050	COG0149	triose-phosphate isomerase activity
TbrSNM41_12060	COG0126	phosphoglycerate kinase activity
TbrSNM41_12080	COG1268	BioY protein
TbrSNM41_12100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TbrSNM41_12130	COG1196	nuclear chromosome segregation
TbrSNM41_12160	COG2738	Putative neutral zinc metallopeptidase
TbrSNM41_12170	COG2897	thiosulfate sulfurtransferase activity
TbrSNM41_12180	COG1410	methionine synthase
TbrSNM41_12180	COG0646	methionine synthase
TbrSNM41_12190	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TbrSNM41_12200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TbrSNM41_12210	COG0740	serine-type endopeptidase activity
TbrSNM41_12220	COG0544	peptidyl-prolyl cis-trans isomerase activity
TbrSNM41_12240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TbrSNM41_12250	COG3870	Protein conserved in bacteria
TbrSNM41_12260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TbrSNM41_12260	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TbrSNM41_12270	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TbrSNM41_12290	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TbrSNM41_12310	COG4475	Protein of unknown function (DUF436)
TbrSNM41_12350	COG3842	ATPase activity
TbrSNM41_12360	COG0572	uridine kinase
TbrSNM41_12410	COG0154	amidase activity
TbrSNM41_12420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TbrSNM41_12440	COG1435	thymidine kinase activity
TbrSNM41_12450	COG0254	rRNA binding
TbrSNM41_12470	COG2001	Belongs to the MraZ family
TbrSNM41_12480	COG0275	rRNA processing
TbrSNM41_12500	COG0768	penicillin binding
TbrSNM41_12510	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TbrSNM41_12530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TbrSNM41_12540	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TbrSNM41_12550	COG0772	Belongs to the SEDS family
TbrSNM41_12560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TbrSNM41_12570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TbrSNM41_12580	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TbrSNM41_12620	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TbrSNM41_12630	COG2197	response regulator
TbrSNM41_12730	COG2391	methyltransferase activity
TbrSNM41_12770	COG1321	iron dependent repressor
TbrSNM41_12790	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_12810	COG1120	ATPase activity
TbrSNM41_12820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TbrSNM41_12840	COG1940	carbohydrate kinase activity
TbrSNM41_12860	COG1175	transmembrane transport
TbrSNM41_12900	COG2423	ornithine cyclodeaminase activity
TbrSNM41_12930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TbrSNM41_12940	COG2264	protein methyltransferase activity
TbrSNM41_12960	COG0489	protein tyrosine kinase activity
TbrSNM41_12980	COG0525	valine-tRNA ligase activity
TbrSNM41_13000	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TbrSNM41_13020	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TbrSNM41_13030	COG0134	indole-3-glycerol-phosphate synthase activity
TbrSNM41_13050	COG3311	Transcriptional regulator
TbrSNM41_13080	COG1126	abc transporter atp-binding protein
TbrSNM41_13100	COG2358	TRAP transporter, solute receptor (TAXI family
TbrSNM41_13110	COG0765	amino acid transport
TbrSNM41_13120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TbrSNM41_13130	COG0058	SHG alpha-glucan phosphorylase activity
TbrSNM41_13140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TbrSNM41_13150	COG0569	domain protein
TbrSNM41_13160	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TbrSNM41_13180	COG2313	pseudouridylate synthase activity
TbrSNM41_13200	COG3001	Fructosamine kinase
TbrSNM41_13210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TbrSNM41_13260	COG0012	GTP binding
TbrSNM41_13270	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TbrSNM41_13290	COG0424	maF-like protein
TbrSNM41_13320	COG0768	penicillin binding
TbrSNM41_13340	COG2322	membrane
TbrSNM41_13380	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TbrSNM41_13390	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TbrSNM41_13400	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TbrSNM41_13420	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TbrSNM41_13440	COG4555	ABC transporter
TbrSNM41_13470	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TbrSNM41_13490	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TbrSNM41_13500	COG0440	acetolactate synthase activity
TbrSNM41_13510	COG0028	Belongs to the TPP enzyme family
TbrSNM41_13520	COG0492	ferredoxin-NADP+ reductase activity
TbrSNM41_13530	COG0861	Integral membrane protein TerC family
TbrSNM41_13550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TbrSNM41_13560	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TbrSNM41_13570	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TbrSNM41_13590	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TbrSNM41_13610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TbrSNM41_13620	COG1024	Enoyl-CoA hydratase
TbrSNM41_13630	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TbrSNM41_13630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TbrSNM41_13670	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TbrSNM41_13680	COG0423	glycine-tRNA ligase activity
TbrSNM41_13690	COG0542	response to heat
TbrSNM41_13700	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TbrSNM41_13710	COG4956	integral membrane protein (PIN domain superfamily)
TbrSNM41_13760	COG1250	3-hydroxyacyl-CoA dehydrogenase
TbrSNM41_13770	COG0697	spore germination
TbrSNM41_13780	COG0612	Peptidase, M16
TbrSNM41_13790	COG0612	Peptidase, M16
TbrSNM41_13800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TbrSNM41_13840	COG0419	ATPase involved in DNA repair
TbrSNM41_13850	COG0420	3'-5' exonuclease activity
TbrSNM41_13880	COG1674	ftsk spoiiie
TbrSNM41_13890	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TbrSNM41_13900	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TbrSNM41_13920	COG4651	solute:proton antiporter activity
TbrSNM41_13920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TbrSNM41_13930	COG0217	transcriptional regulatory protein
TbrSNM41_13940	COG0653	protein targeting
TbrSNM41_13950	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TbrSNM41_13990	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_14010	COG0312	modulator of DNA gyrase
TbrSNM41_14040	COG0730	response to heat
TbrSNM41_14060	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TbrSNM41_14080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TbrSNM41_14090	COG0167	dihydroorotate dehydrogenase activity
TbrSNM41_14110	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TbrSNM41_14120	COG0746	molybdenum cofactor guanylyltransferase activity
TbrSNM41_14150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TbrSNM41_14160	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TbrSNM41_14210	COG0318	PFAM AMP-dependent synthetase and ligase
TbrSNM41_14220	COG3360	Dodecin
TbrSNM41_14250	COG1024	Enoyl-CoA hydratase
TbrSNM41_14260	COG0813	purine-nucleoside phosphorylase activity
TbrSNM41_14270	COG1136	(ABC) transporter
TbrSNM41_14280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TbrSNM41_14290	COG2045	Belongs to the ComB family
TbrSNM41_14310	COG0789	Transcriptional regulator
TbrSNM41_14320	COG1414	Transcriptional regulator
TbrSNM41_14330	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TbrSNM41_14340	COG0277	FAD linked oxidase domain protein
TbrSNM41_14350	COG0277	FAD linked oxidase domain protein
TbrSNM41_14360	COG0247	lactate metabolic process
TbrSNM41_14380	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TbrSNM41_14390	COG2050	protein possibly involved in aromatic compounds catabolism
TbrSNM41_14450	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TbrSNM41_14460	COG0460	homoserine dehydrogenase
TbrSNM41_14470	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TbrSNM41_14500	COG2226	methyltransferase
TbrSNM41_14520	COG0366	Alpha amylase catalytic
TbrSNM41_14540	COG0037	tRNA processing
TbrSNM41_14550	COG2104	thiamine diphosphate biosynthetic process
TbrSNM41_14560	COG0123	including yeast histone deacetylase and acetoin utilization protein
TbrSNM41_14570	COG0517	IMP dehydrogenase activity
TbrSNM41_14590	COG0444	Belongs to the ABC transporter superfamily
TbrSNM41_14600	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TbrSNM41_14610	COG0601	transmembrane transport
TbrSNM41_14620	COG0747	negative chemotaxis
TbrSNM41_14640	COG1063	alcohol dehydrogenase
TbrSNM41_14650	COG0492	ferredoxin-NADP+ reductase activity
TbrSNM41_14700	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TbrSNM41_14700	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TbrSNM41_14710	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TbrSNM41_14720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TbrSNM41_14750	COG0446	pyridine nucleotide-disulphide oxidoreductase
TbrSNM41_14750	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TbrSNM41_14760	COG2070	2-Nitropropane dioxygenase
TbrSNM41_14800	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_14810	COG2205	protein histidine kinase activity
TbrSNM41_14830	COG3335	DDE superfamily endonuclease
TbrSNM41_14860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TbrSNM41_14880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TbrSNM41_14910	COG0351	phosphomethylpyrimidine kinase
TbrSNM41_14910	COG0352	thiamine-phosphate diphosphorylase activity
TbrSNM41_14920	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TbrSNM41_14930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TbrSNM41_14930	COG2022	thiamine diphosphate biosynthetic process
TbrSNM41_14940	COG2022	thiamine diphosphate biosynthetic process
TbrSNM41_14950	COG2104	thiamine diphosphate biosynthetic process
TbrSNM41_14960	COG0352	thiamine-phosphate diphosphorylase activity
TbrSNM41_14970	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TbrSNM41_14980	COG1587	Uroporphyrinogen-III synthase
TbrSNM41_14990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TbrSNM41_14990	COG1648	precorrin-2 dehydrogenase activity
TbrSNM41_15000	COG0175	sulfate reduction
TbrSNM41_15010	COG0730	response to heat
TbrSNM41_15020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TbrSNM41_15020	COG1648	precorrin-2 dehydrogenase activity
TbrSNM41_15030	COG2046	Belongs to the sulfate adenylyltransferase family
TbrSNM41_15040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TbrSNM41_15050	COG0513	Belongs to the DEAD box helicase family
TbrSNM41_15080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
TbrSNM41_15100	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TbrSNM41_15110	COG0442	prolyl-tRNA aminoacylation
TbrSNM41_15190	COG0395	ABC-type sugar transport system, permease component
TbrSNM41_15200	COG1175	transmembrane transport
TbrSNM41_15240	COG0084	hydrolase, TatD family'
TbrSNM41_15270	COG0017	Asparaginyl-tRNA synthetase
TbrSNM41_15280	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TbrSNM41_15310	COG2009	succinate dehydrogenase
TbrSNM41_15320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TbrSNM41_15380	COG0318	PFAM AMP-dependent synthetase and ligase
TbrSNM41_15390	COG1104	cysteine desulfurase activity
TbrSNM41_15400	COG1104	cysteine desulfurase activity
TbrSNM41_15420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TbrSNM41_15430	COG1121	(ABC) transporter
TbrSNM41_15480	COG0318	PFAM AMP-dependent synthetase and ligase
TbrSNM41_15520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TbrSNM41_15530	COG0706	membrane insertase activity
TbrSNM41_15540	COG1837	Belongs to the UPF0109 family
TbrSNM41_15550	COG2890	protein-(glutamine-N5) methyltransferase activity
TbrSNM41_15580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TbrSNM41_15620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TbrSNM41_15640	COG0180	Tryptophanyl-tRNA synthetase
TbrSNM41_15650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TbrSNM41_15660	COG0066	3-isopropylmalate dehydratase activity
TbrSNM41_15690	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_15700	COG0129	dihydroxy-acid dehydratase activity
TbrSNM41_15710	COG2010	Cytochrome c
TbrSNM41_15730	COG1177	transmembrane transport
TbrSNM41_15740	COG1176	ABC-type spermidine putrescine transport system, permease component I
TbrSNM41_15750	COG3842	ATPase activity
TbrSNM41_15760	COG0772	Belongs to the SEDS family
TbrSNM41_15770	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TbrSNM41_15780	COG2894	cell division
TbrSNM41_15790	COG1733	regulation of RNA biosynthetic process
TbrSNM41_15810	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TbrSNM41_15810	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TbrSNM41_15830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TbrSNM41_15840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TbrSNM41_15850	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TbrSNM41_15870	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TbrSNM41_15890	COG0516	GMP reductase activity
TbrSNM41_15890	COG0517	IMP dehydrogenase activity
TbrSNM41_15910	COG2198	Histidine kinase
TbrSNM41_15910	COG2205	protein histidine kinase activity
TbrSNM41_15910	COG0784	Response regulator, receiver
TbrSNM41_15920	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_15930	COG2176	DNA-directed DNA polymerase activity
TbrSNM41_15940	COG0151	Belongs to the GarS family
TbrSNM41_15950	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TbrSNM41_15970	COG0179	Fumarylacetoacetate (FAA) hydrolase
TbrSNM41_15980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TbrSNM41_15990	COG1609	Transcriptional regulator
TbrSNM41_16020	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TbrSNM41_16030	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TbrSNM41_16050	COG2514	catechol 2,3-dioxygenase activity
TbrSNM41_16060	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TbrSNM41_16070	COG0287	Prephenate dehydrogenase
TbrSNM41_16090	COG0277	FAD linked oxidase domain protein
TbrSNM41_16120	COG1459	type II secretion system
TbrSNM41_16130	COG0009	L-threonylcarbamoyladenylate synthase
TbrSNM41_16140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TbrSNM41_16160	COG0456	acetyltransferase
TbrSNM41_16160	COG0454	-acetyltransferase
TbrSNM41_16170	COG0393	Putative heavy-metal-binding
TbrSNM41_16180	COG1111	helicase
TbrSNM41_16180	COG1205	dead DEAH box helicase
TbrSNM41_16210	COG0358	DNA primase activity
TbrSNM41_16240	COG3335	DDE superfamily endonuclease
TbrSNM41_16250	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TbrSNM41_16270	COG2813	Specifically methylates the guanine in position
TbrSNM41_16340	COG0494	nUDIX hydrolase
TbrSNM41_16350	COG0196	riboflavin kinase activity
TbrSNM41_16370	COG2197	response regulator
TbrSNM41_16390	COG0243	molybdopterin cofactor binding
TbrSNM41_16430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TbrSNM41_16440	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TbrSNM41_16450	COG0509	glycine decarboxylation via glycine cleavage system
TbrSNM41_16460	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TbrSNM41_16490	COG0281	malic enzyme
TbrSNM41_16500	COG2151	metal-sulfur cluster biosynthetic enzyme
TbrSNM41_16510	COG0861	Integral membrane protein TerC family
TbrSNM41_16570	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TbrSNM41_16580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TbrSNM41_16590	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TbrSNM41_16600	COG0131	Imidazoleglycerol-phosphate dehydratase
TbrSNM41_16610	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TbrSNM41_16620	COG0778	Nitroreductase
TbrSNM41_16910	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TbrSNM41_17010	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
TbrSNM41_17080	COG0210	DNA helicase
TbrSNM41_17220	COG4712	double-strand break repair protein
TbrSNM41_17240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TbrSNM41_17250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TbrSNM41_17260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TbrSNM41_17270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TbrSNM41_17280	COG0649	NAD binding
TbrSNM41_17290	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TbrSNM41_17300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TbrSNM41_17310	COG1034	ATP synthesis coupled electron transport
TbrSNM41_17320	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TbrSNM41_17330	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TbrSNM41_17340	COG0839	Belongs to the complex I subunit 6 family
TbrSNM41_17350	COG0713	ATP synthesis coupled electron transport
TbrSNM41_17360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TbrSNM41_17370	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TbrSNM41_17380	COG1007	ATP synthesis coupled electron transport
TbrSNM41_17450	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TbrSNM41_17460	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TbrSNM41_17470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TbrSNM41_17490	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TbrSNM41_17500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TbrSNM41_17510	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TbrSNM41_17520	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TbrSNM41_17550	COG0564	pseudouridine synthase activity
TbrSNM41_17560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TbrSNM41_17570	COG2255	four-way junction helicase activity
TbrSNM41_17610	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TbrSNM41_17630	COG1085	galactose-1-phosphate uridylyltransferase
TbrSNM41_17640	COG3345	alpha-galactosidase
TbrSNM41_17660	COG0395	ABC-type sugar transport system, permease component
TbrSNM41_17680	COG1653	transport
TbrSNM41_17690	COG1349	DNA-binding transcription factor activity
TbrSNM41_17710	COG2211	Major facilitator Superfamily
TbrSNM41_17730	COG1181	Belongs to the D-alanine--D-alanine ligase family
TbrSNM41_17740	COG0193	aminoacyl-tRNA hydrolase activity
TbrSNM41_17750	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TbrSNM41_17760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TbrSNM41_17770	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TbrSNM41_17780	COG1854	S-ribosylhomocysteine lyase activity
TbrSNM41_17810	COG0519	Catalyzes the synthesis of GMP from XMP
TbrSNM41_17810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TbrSNM41_17820	COG4274	PFAM GYD family protein
TbrSNM41_17840	COG0113	porphobilinogen synthase activity
TbrSNM41_17850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TbrSNM41_17860	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TbrSNM41_17910	COG0823	Involved in the tonB-independent uptake of proteins
TbrSNM41_17910	COG1506	peptidase
TbrSNM41_17910	COG4946	Tricorn protease homolog
TbrSNM41_17920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TbrSNM41_17930	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TbrSNM41_17980	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TbrSNM41_17990	COG1011	Hydrolase
TbrSNM41_18000	COG1361	Conserved repeat domain
TbrSNM41_18000	COG2911	Protein conserved in bacteria
TbrSNM41_18000	COG3266	domain, Protein
TbrSNM41_18020	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TbrSNM41_18050	COG0537	adenosine 5'-monophosphoramidase activity
TbrSNM41_18060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TbrSNM41_18070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TbrSNM41_18080	COG1324	tolerance protein
TbrSNM41_18090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TbrSNM41_18130	COG2205	protein histidine kinase activity
TbrSNM41_18140	COG0822	iron-sulfur transferase activity
TbrSNM41_18170	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TbrSNM41_18190	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TbrSNM41_18200	COG0284	orotidine-5'-phosphate decarboxylase activity
TbrSNM41_18210	COG1404	Belongs to the peptidase S8 family
TbrSNM41_18280	COG0497	DNA recombination
TbrSNM41_18300	COG2095	MarC family integral membrane protein
TbrSNM41_18310	COG1438	arginine binding
TbrSNM41_18320	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TbrSNM41_18340	COG0194	GDP metabolic process
TbrSNM41_18360	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TbrSNM41_18370	COG2385	sporulation resulting in formation of a cellular spore
TbrSNM41_18380	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TbrSNM41_18400	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TbrSNM41_18460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TbrSNM41_18470	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TbrSNM41_18500	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TbrSNM41_18570	COG0203	ribosomal protein L17
TbrSNM41_18590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TbrSNM41_18600	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TbrSNM41_18610	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TbrSNM41_18620	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TbrSNM41_18640	COG0563	adenylate kinase activity
TbrSNM41_18650	COG0201	protein transport
TbrSNM41_18700	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TbrSNM41_18770	COG0255	Belongs to the universal ribosomal protein uL29 family
TbrSNM41_18780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TbrSNM41_18790	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TbrSNM41_18810	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TbrSNM41_18820	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TbrSNM41_18830	COG0089	rRNA binding
TbrSNM41_18840	COG0088	Forms part of the polypeptide exit tunnel
TbrSNM41_18860	COG0051	transcription antitermination factor activity, RNA binding
TbrSNM41_18890	COG0049	tRNA binding
TbrSNM41_18950	COG1461	Dihydroxyacetone kinase
TbrSNM41_18970	COG0686	Belongs to the AlaDH PNT family
TbrSNM41_18980	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TbrSNM41_18990	COG1024	Enoyl-CoA hydratase
TbrSNM41_19000	COG1187	pseudouridine synthase activity
TbrSNM41_19010	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TbrSNM41_19040	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TbrSNM41_19060	COG0512	Glutamine amidotransferase of anthranilate synthase
TbrSNM41_19070	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TbrSNM41_19080	COG1012	belongs to the aldehyde dehydrogenase family
TbrSNM41_19090	COG0506	proline dehydrogenase activity
TbrSNM41_19140	COG0156	8-amino-7-oxononanoate synthase activity
TbrSNM41_19170	COG0187	DNA topoisomerase II activity
TbrSNM41_19180	COG1643	Atp-dependent helicase
TbrSNM41_19210	COG1063	alcohol dehydrogenase
TbrSNM41_19320	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TbrSNM41_19320	COG1605	Chorismate mutase
TbrSNM41_19330	COG0805	protein transport
TbrSNM41_19340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TbrSNM41_19350	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TbrSNM41_19360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TbrSNM41_19390	COG0686	Belongs to the AlaDH PNT family
TbrSNM41_19400	COG0427	acetyl-CoA hydrolase
TbrSNM41_19410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TbrSNM41_19430	COG2720	vancomycin resistance protein
TbrSNM41_19440	COG1187	pseudouridine synthase activity
TbrSNM41_19470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TbrSNM41_19480	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_19490	COG1960	acyl-CoA dehydrogenase activity
TbrSNM41_19500	COG0163	prenyltransferase activity
TbrSNM41_19510	COG0222	ribosome binding
TbrSNM41_19520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TbrSNM41_19570	COG0081	regulation of translation
TbrSNM41_19590	COG0250	Participates in transcription elongation, termination and antitermination
TbrSNM41_19600	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TbrSNM41_19610	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TbrSNM41_19630	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TbrSNM41_19640	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TbrSNM41_19650	COG1335	isochorismatase
TbrSNM41_19660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TbrSNM41_19680	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TbrSNM41_19700	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TbrSNM41_19710	COG1993	acr, cog1993
TbrSNM41_19780	COG0437	4 iron, 4 sulfur cluster binding
TbrSNM41_19860	COG1309	transcriptional regulator
TbrSNM41_19890	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TbrSNM41_19900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TbrSNM41_19910	COG1968	undecaprenyl-diphosphatase activity
TbrSNM41_19920	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TbrSNM41_19930	COG0484	heat shock protein binding
TbrSNM41_19940	COG1278	Cold shock
TbrSNM41_19960	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TbrSNM41_19970	COG2217	Heavy metal translocating P-type atpase
TbrSNM41_20010	COG0825	malonyl-CoA metabolic process
TbrSNM41_20020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TbrSNM41_20040	COG0739	heme binding
TbrSNM41_20080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TbrSNM41_20100	COG0799	negative regulation of ribosome biogenesis
TbrSNM41_20120	COG1713	HD superfamily hydrolase involved in NAD metabolism
TbrSNM41_20120	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TbrSNM41_20130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TbrSNM41_20140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TbrSNM41_20150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TbrSNM41_20160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TbrSNM41_20190	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TbrSNM41_20200	COG0505	Belongs to the CarA family
TbrSNM41_20210	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TbrSNM41_20210	COG0165	Argininosuccinate lyase
TbrSNM41_20220	COG0165	Argininosuccinate lyase
TbrSNM41_20230	COG0137	argininosuccinate synthase activity
TbrSNM41_20250	COG0508	dehydrogenase complex catalyzes the overall conversion of
TbrSNM41_20270	COG1024	Enoyl-CoA hydratase
TbrSNM41_20280	COG0632	four-way junction helicase activity
TbrSNM41_20290	COG0577	efflux transmembrane transporter activity
TbrSNM41_20290	COG1136	(ABC) transporter
TbrSNM41_20300	COG1136	(ABC) transporter
TbrSNM41_20340	COG0642	Histidine kinase
TbrSNM41_20410	COG3253	May function as heme-dependent peroxidase
TbrSNM41_20430	COG0667	Aldo Keto reductase
TbrSNM41_20450	COG0277	FAD linked oxidase domain protein
TbrSNM41_20470	COG1136	(ABC) transporter
TbrSNM41_20470	COG0577	efflux transmembrane transporter activity
TbrSNM41_20480	COG4181	ATPase activity
TbrSNM41_20490	COG0446	pyridine nucleotide-disulphide oxidoreductase
TbrSNM41_20520	COG0396	ATPase activity
TbrSNM41_20530	COG0719	Fe-S assembly protein
TbrSNM41_20540	COG0719	Fe-S assembly protein
TbrSNM41_20600	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_20610	COG5002	protein histidine kinase activity
TbrSNM41_20660	COG2226	methyltransferase
TbrSNM41_20710	COG2132	Multicopper oxidase
TbrSNM41_20720	COG2217	Heavy metal translocating P-type atpase
TbrSNM41_20730	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TbrSNM41_20750	COG1139	Iron-sulfur cluster binding protein
TbrSNM41_20780	COG1752	Esterase of the alpha-beta hydrolase superfamily
TbrSNM41_20790	COG2815	serine threonine protein kinase
TbrSNM41_20790	COG0515	serine threonine protein kinase
TbrSNM41_20800	COG0860	N-Acetylmuramoyl-L-alanine amidase
TbrSNM41_20820	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TbrSNM41_20900	COG0784	Response regulator, receiver
TbrSNM41_20900	COG3437	response regulator, receiver
TbrSNM41_20920	COG0473	3-isopropylmalate dehydrogenase activity
TbrSNM41_20970	COG1450	Type ii and iii secretion system protein
TbrSNM41_20980	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TbrSNM41_20990	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TbrSNM41_21000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TbrSNM41_21010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TbrSNM41_21010	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TbrSNM41_21020	COG0736	holo-[acyl-carrier-protein] synthase activity
TbrSNM41_21050	COG1160	GTP binding
TbrSNM41_21060	COG0631	protein serine/threonine phosphatase activity
TbrSNM41_21070	COG0105	UTP biosynthetic process
TbrSNM41_21090	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TbrSNM41_21120	COG0477	Major facilitator Superfamily
TbrSNM41_21150	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TbrSNM41_21170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TbrSNM41_21190	COG0243	molybdopterin cofactor binding
TbrSNM41_21210	COG0301	tRNA thio-modification
TbrSNM41_21220	COG0154	amidase activity
TbrSNM41_21230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TbrSNM41_21300	COG0521	Mo-molybdopterin cofactor biosynthetic process
TbrSNM41_21310	COG0436	Aminotransferase
TbrSNM41_21320	COG0285	dihydrofolate synthase activity
TbrSNM41_21340	COG0181	hydroxymethylbilane synthase activity
TbrSNM41_21350	COG0508	dehydrogenase complex catalyzes the overall conversion of
TbrSNM41_21370	COG0583	DNA-binding transcription factor activity
TbrSNM41_21400	COG0735	belongs to the Fur family
TbrSNM41_21410	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TbrSNM41_21430	COG0482	sulfurtransferase activity
TbrSNM41_21450	COG0573	inorganic phosphate transmembrane transporter activity
TbrSNM41_21460	COG0581	inorganic phosphate transmembrane transporter activity
TbrSNM41_21470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TbrSNM41_21480	COG2814	Major facilitator Superfamily
TbrSNM41_21490	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TbrSNM41_21510	COG2096	Adenosyltransferase
TbrSNM41_21530	COG1131	(ABC) transporter
TbrSNM41_21540	COG1668	transmembrane transport
TbrSNM41_21590	COG1660	Displays ATPase and GTPase activities
TbrSNM41_21600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TbrSNM41_21630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TbrSNM41_21690	COG0072	phenylalanine-tRNA ligase activity
TbrSNM41_21690	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TbrSNM41_21710	COG0205	6-phosphofructokinase activity
TbrSNM41_21720	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TbrSNM41_21740	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TbrSNM41_21780	COG2333	competence protein COMEC
TbrSNM41_21780	COG0658	competence protein
TbrSNM41_21790	COG1475	DNA binding
TbrSNM41_21800	COG1192	Involved in chromosome partitioning
TbrSNM41_21810	COG0357	Ribosomal RNA small subunit methyltransferase G
TbrSNM41_21820	COG2723	6-phospho-beta-galactosidase activity
TbrSNM41_21830	COG4565	transcriptional regulatory protein
TbrSNM41_21840	COG3290	protein histidine kinase activity
TbrSNM41_21850	COG3842	ATPase activity
TbrSNM41_21890	COG0410	ABC transporter
TbrSNM41_21940	COG1028	Short-chain dehydrogenase reductase Sdr
TbrSNM41_21950	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TbrSNM41_21960	COG0789	Transcriptional regulator
TbrSNM41_22000	COG0588	phosphoglycerate mutase activity
TbrSNM41_22080	COG1857	crispr-associated protein
TbrSNM41_22170	COG1131	(ABC) transporter
TbrSNM41_22190	COG0523	cobalamin synthesis protein
TbrSNM41_22230	COG0803	Belongs to the bacterial solute-binding protein 9 family
TbrSNM41_22260	COG1785	Belongs to the alkaline phosphatase family
TbrSNM41_22270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TbrSNM41_22290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TbrSNM41_22310	COG1562	ergosterol biosynthetic process
TbrSNM41_22320	COG0415	Belongs to the DNA photolyase family
TbrSNM41_22360	COG0463	Glycosyl transferase, family 2
TbrSNM41_22380	COG1304	FMN binding
TbrSNM41_22550	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TbrSNM41_22560	COG0248	Ppx GppA phosphatase
TbrSNM41_22570	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TbrSNM41_22580	COG3177	Filamentation induced by cAMP protein fic
TbrSNM41_22640	COG1797	cobyrinic acid a,c-diamide synthase activity
TbrSNM41_22650	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TbrSNM41_22660	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TbrSNM41_22680	COG0588	phosphoglycerate mutase activity
TbrSNM41_22700	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TbrSNM41_22790	COG1648	precorrin-2 dehydrogenase activity
TbrSNM41_22790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TbrSNM41_22800	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TbrSNM41_22810	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TbrSNM41_22820	COG1492	cobalamin metabolic process
TbrSNM41_22860	COG1233	COG1233 Phytoene dehydrogenase and related
TbrSNM41_22890	COG0702	epimerase
TbrSNM41_22920	COG2353	YceI-like domain
TbrSNM41_22940	COG4294	response to UV
TbrSNM41_22950	COG1475	DNA binding
TbrSNM41_22960	COG3800	Transcriptional regulator
TbrSNM41_22960	COG1396	sequence-specific DNA binding
TbrSNM41_22990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TbrSNM41_23000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TbrSNM41_23000	COG1116	anion transmembrane transporter activity
TbrSNM41_23010	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TbrSNM41_23080	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TbrSNM41_23090	COG3335	DDE superfamily endonuclease
TbrSNM41_23120	COG1475	DNA binding
TbrSNM41_23130	COG1192	Involved in chromosome partitioning
TbrSNM41_23190	COG1337	RAMP superfamily
TbrSNM41_23230	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TbrSNM41_23390	COG1518	maintenance of DNA repeat elements
TbrSNM41_23460	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TbrSNM41_23560	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TbrSNM41_23590	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TbrSNM41_23600	COG2342	PFAM TM1410 hypothetical-related protein
TbrSNM41_23690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TbrSNM41_23700	COG0601	transmembrane transport
TbrSNM41_23710	COG0747	negative chemotaxis
TbrSNM41_23770	COG1012	belongs to the aldehyde dehydrogenase family
TbrSNM41_23790	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TbrSNM41_23830	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TbrSNM41_23870	COG4213	ABC transporter substrate-binding protein
TbrSNM41_23880	COG4214	carbohydrate transport
TbrSNM41_23890	COG1129	ABC transporter
TbrSNM41_23920	COG1070	Carbohydrate kinase
TbrSNM41_23930	COG0006	proline dipeptidase activity
TbrSNM41_23990	COG4558	Periplasmic binding protein
TbrSNM41_24000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TbrSNM41_24010	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TbrSNM41_24030	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TbrSNM41_24060	COG1607	acyl-coa hydrolase
TbrSNM41_24080	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TbrSNM41_24120	COG0395	ABC-type sugar transport system, permease component
TbrSNM41_24130	COG1175	transmembrane transport
TbrSNM41_24210	COG0210	DNA helicase
TbrSNM41_24280	COG1192	Involved in chromosome partitioning
TbrSNM41_24290	COG1475	DNA binding
TbrSNM41_24360	COG0587	DNA-directed DNA polymerase activity
TbrSNM41_24520	COG3335	DDE superfamily endonuclease
TbrSNM41_24540	COG2199	diguanylate cyclase activity
TbrSNM41_24540	COG2200	EAL domain
TbrSNM41_24650	COG2132	Multicopper oxidase
TbrSNM41_24670	COG2217	Heavy metal translocating P-type atpase
TbrSNM41_24890	COG2205	protein histidine kinase activity
TbrSNM41_24900	COG0745	RESPONSE REGULATOR receiver
TbrSNM41_24950	COG0628	permease
TbrSNM41_24980	COG1609	Transcriptional regulator
TbrSNM41_25000	COG1175	transmembrane transport
TbrSNM41_25090	COG1192	Involved in chromosome partitioning
TbrSNM41_25130	COG4974	Belongs to the 'phage' integrase family
TbrSNM41_t00390	COG0544	peptidyl-prolyl cis-trans isomerase activity