locus-tag	class	description
Theos_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Theos_0002	COG0592	DNA-directed DNA polymerase activity
Theos_0003	COG0148	phosphopyruvate hydratase activity
Theos_0004	COG0469	pyruvate kinase activity
Theos_0006	COG0284	orotidine-5'-phosphate decarboxylase activity
Theos_0007	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Theos_0009	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Theos_0010	COG1013	pyruvate-flavodoxin oxidoreductase activity
Theos_0011	COG0674	pyruvate-flavodoxin oxidoreductase activity
Theos_0011	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Theos_0013	COG1937	Protein conserved in bacteria
Theos_0014	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Theos_0016	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Theos_0017	COG0693	protein deglycase activity
Theos_0018	COG0494	nUDIX hydrolase
Theos_0019	COG3956	TIGRFAM MazG family protein
Theos_0021	COG2847	Copper chaperone PCu(A)C
Theos_0022	COG1999	signal sequence binding
Theos_0024	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Theos_0026	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Theos_0027	COG0459	protein refolding
Theos_0028	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Theos_0029	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Theos_0032	COG0166	Belongs to the GPI family
Theos_0033	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Theos_0034	COG0109	protoheme IX farnesyltransferase activity
Theos_0034	COG1612	heme a metabolic process
Theos_0036	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Theos_0036	COG1845	cytochrome c oxidase, subunit III
Theos_0041	COG0582	viral genome integration into host DNA
Theos_0052	COG1304	FMN binding
Theos_0054	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Theos_0056	COG0668	transmembrane transport
Theos_0062	COG0745	RESPONSE REGULATOR receiver
Theos_0063	COG2205	protein histidine kinase activity
Theos_0065	COG1355	regulation of microtubule-based process
Theos_0072	COG1489	DNA binding
Theos_0075	COG1115	amino acid carrier protein
Theos_0080	COG0442	prolyl-tRNA aminoacylation
Theos_0082	COG0277	FAD linked oxidase domain protein
Theos_0085	COG0822	iron-sulfur transferase activity
Theos_0086	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Theos_0088	COG2132	Multicopper oxidase
Theos_0092	COG2226	methyltransferase
Theos_0094	COG5002	protein histidine kinase activity
Theos_0095	COG0745	RESPONSE REGULATOR receiver
Theos_0101	COG0577	efflux transmembrane transporter activity
Theos_0101	COG1136	(ABC) transporter
Theos_0102	COG4181	ATPase activity
Theos_0105	COG1082	Xylose isomerase domain protein TIM barrel
Theos_0106	COG2010	Cytochrome c
Theos_0108	COG0723	plastoquinol--plastocyanin reductase activity
Theos_0109	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Theos_0111	COG0719	Fe-S assembly protein
Theos_0112	COG0719	Fe-S assembly protein
Theos_0113	COG0396	ATPase activity
Theos_0116	COG0446	pyridine nucleotide-disulphide oxidoreductase
Theos_0118	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Theos_0120	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Theos_0125	COG0505	Belongs to the CarA family
Theos_0128	COG0165	Argininosuccinate lyase
Theos_0128	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Theos_0129	COG0165	Argininosuccinate lyase
Theos_0130	COG0137	argininosuccinate synthase activity
Theos_0132	COG0508	dehydrogenase complex catalyzes the overall conversion of
Theos_0134	COG1024	Enoyl-CoA hydratase
Theos_0135	COG0632	four-way junction helicase activity
Theos_0136	COG1011	Hydrolase
Theos_0138	COG1611	Belongs to the LOG family
Theos_0139	COG0589	response to stress
Theos_0141	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Theos_0143	COG1940	carbohydrate kinase activity
Theos_0152	COG0302	gtp cyclohydrolase
Theos_0157	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Theos_0159	COG0395	ABC-type sugar transport system, permease component
Theos_0160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Theos_0160	COG0574	Belongs to the PEP-utilizing enzyme family
Theos_0162	COG3005	denitrification pathway
Theos_0165	COG1131	(ABC) transporter
Theos_0169	COG0556	nucleotide-excision repair
Theos_0170	COG0497	DNA recombination
Theos_0171	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Theos_0172	COG0745	RESPONSE REGULATOR receiver
Theos_0173	COG2205	protein histidine kinase activity
Theos_0174	COG0704	Plays a role in the regulation of phosphate uptake
Theos_0178	COG1546	Belongs to the CinA family
Theos_0178	COG1058	Belongs to the CinA family
Theos_0179	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Theos_0181	COG1418	mRNA catabolic process
Theos_0181	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Theos_0182	COG1077	Cell shape determining protein MreB Mrl
Theos_0183	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Theos_0185	COG0085	RNA polymerase activity
Theos_0187	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Theos_0187	COG0235	Class ii aldolase
Theos_0190	COG4143	(ABC) transporter
Theos_0191	COG1177	transmembrane transport
Theos_0192	COG1660	Displays ATPase and GTPase activities
Theos_0193	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Theos_0198	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Theos_0200	COG0628	permease
Theos_0202	COG0343	queuine tRNA-ribosyltransferase activity
Theos_0205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Theos_0206	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Theos_0209	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Theos_0211	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Theos_0212	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Theos_0214	COG0242	peptide deformylase activity
Theos_0215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Theos_0225	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Theos_0227	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Theos_0227	COG0515	serine threonine protein kinase
Theos_0228	COG0251	oxidation-reduction process
Theos_0232	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Theos_0233	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_0236	COG0717	Belongs to the dCTP deaminase family
Theos_0238	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Theos_0239	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Theos_0240	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Theos_0242	COG0583	DNA-binding transcription factor activity
Theos_0243	COG3546	catalase activity
Theos_0244	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Theos_0244	COG0758	DNA mediated transformation
Theos_0245	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Theos_0248	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Theos_0251	COG0301	tRNA thio-modification
Theos_0254	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Theos_0255	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Theos_0256	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Theos_0257	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Theos_0260	COG0799	negative regulation of ribosome biogenesis
Theos_0262	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Theos_0269	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Theos_0270	COG0825	malonyl-CoA metabolic process
Theos_0272	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Theos_0273	COG0049	tRNA binding
Theos_0274	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Theos_0276	COG0051	transcription antitermination factor activity, RNA binding
Theos_0277	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Theos_0278	COG0088	Forms part of the polypeptide exit tunnel
Theos_0279	COG0089	rRNA binding
Theos_0280	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Theos_0281	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Theos_0282	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Theos_0283	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Theos_0284	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Theos_0285	COG0255	Belongs to the universal ribosomal protein uL29 family
Theos_0289	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Theos_0293	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Theos_0294	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Theos_0295	COG1841	ribosomal large subunit assembly
Theos_0296	COG0200	Binds to the 23S rRNA
Theos_0297	COG0201	protein transport
Theos_0298	COG0563	adenylate kinase activity
Theos_0300	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Theos_0301	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Theos_0302	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Theos_0303	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Theos_0304	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Theos_0305	COG0202	RNA polymerase activity
Theos_0306	COG0203	ribosomal protein L17
Theos_0314	COG0142	geranyltranstransferase activity
Theos_0315	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Theos_0318	COG1175	transmembrane transport
Theos_0319	COG3833	ABC-type maltose transport systems, permease component
Theos_0320	COG0366	Alpha amylase catalytic
Theos_0322	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Theos_0325	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Theos_0327	COG0047	phosphoribosylformylglycinamidine synthase activity
Theos_0329	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Theos_0330	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Theos_0332	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Theos_0335	COG0497	DNA recombination
Theos_0344	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Theos_0345	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Theos_0346	COG0113	porphobilinogen synthase activity
Theos_0349	COG0631	protein serine/threonine phosphatase activity
Theos_0350	COG0515	serine threonine protein kinase
Theos_0350	COG2815	serine threonine protein kinase
Theos_0356	COG0210	DNA helicase
Theos_0357	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Theos_0363	COG0537	adenosine 5'-monophosphoramidase activity
Theos_0364	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theos_0366	COG0135	phosphoribosylanthranilate isomerase activity
Theos_0368	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
Theos_0369	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Theos_0370	COG0714	Associated with various cellular activities
Theos_0371	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Theos_0371	COG0574	Belongs to the PEP-utilizing enzyme family
Theos_0372	COG1272	protein, Hemolysin III
Theos_0374	COG5002	protein histidine kinase activity
Theos_0374	COG3850	Histidine kinase
Theos_0380	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Theos_0386	COG0745	RESPONSE REGULATOR receiver
Theos_0386	COG3706	GGDEF domain
Theos_0387	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Theos_0388	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Theos_0389	COG1611	Belongs to the LOG family
Theos_0391	COG1193	negative regulation of DNA recombination
Theos_0392	COG1166	arginine decarboxylase activity
Theos_0395	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Theos_0398	COG0747	negative chemotaxis
Theos_0399	COG0601	transmembrane transport
Theos_0400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Theos_0401	COG0101	tRNA pseudouridine synthase activity
Theos_0402	COG3842	ATPase activity
Theos_0407	COG1764	response to oxidative stress
Theos_0409	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theos_0412	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Theos_0413	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Theos_0416	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Theos_0418	COG2720	vancomycin resistance protein
Theos_0419	COG1187	pseudouridine synthase activity
Theos_0421	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_0422	COG0492	ferredoxin-NADP+ reductase activity
Theos_0424	COG0792	nuclease activity
Theos_0425	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Theos_0426	COG1160	GTP binding
Theos_0430	COG0736	holo-[acyl-carrier-protein] synthase activity
Theos_0431	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Theos_0431	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Theos_0432	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Theos_0433	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Theos_0434	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Theos_0435	COG1450	Type ii and iii secretion system protein
Theos_0440	COG0473	3-isopropylmalate dehydrogenase activity
Theos_0447	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Theos_0449	COG0860	N-Acetylmuramoyl-L-alanine amidase
Theos_0450	COG0515	serine threonine protein kinase
Theos_0450	COG2815	serine threonine protein kinase
Theos_0451	COG1752	Esterase of the alpha-beta hydrolase superfamily
Theos_0454	COG1139	Iron-sulfur cluster binding protein
Theos_0455	COG0247	lactate metabolic process
Theos_0461	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Theos_0467	COG2244	polysaccharide biosynthetic process
Theos_0469	COG1216	Glycosyl transferase, family 2
Theos_0473	COG0438	transferase activity, transferring glycosyl groups
Theos_0481	COG2205	protein histidine kinase activity
Theos_0485	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Theos_0487	COG1324	tolerance protein
Theos_0488	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Theos_0490	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Theos_0491	COG0739	heme binding
Theos_0492	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Theos_0493	COG2197	response regulator
Theos_0496	COG0776	regulation of translation
Theos_0498	COG1515	deoxyribonuclease V activity
Theos_0500	COG1482	cell wall glycoprotein biosynthetic process
Theos_0501	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Theos_0502	COG0372	Belongs to the citrate synthase family
Theos_0503	COG1132	(ABC) transporter
Theos_0504	COG1132	(ABC) transporter
Theos_0507	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Theos_0508	COG0601	transmembrane transport
Theos_0509	COG0747	negative chemotaxis
Theos_0513	COG0559	Belongs to the binding-protein-dependent transport system permease family
Theos_0515	COG0174	glutamine synthetase
Theos_0516	COG0737	Belongs to the 5'-nucleotidase family
Theos_0518	COG2010	Cytochrome c
Theos_0520	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Theos_0521	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Theos_0522	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Theos_0523	COG0788	formyltetrahydrofolate deformylase activity
Theos_0524	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theos_0527	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Theos_0530	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Theos_0531	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Theos_0532	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Theos_0536	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theos_0539	COG0746	molybdenum cofactor guanylyltransferase activity
Theos_0547	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Theos_0549	COG0167	dihydroorotate dehydrogenase activity
Theos_0551	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Theos_0554	COG0540	Belongs to the ATCase OTCase family
Theos_0555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Theos_0557	COG0730	response to heat
Theos_0558	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Theos_0561	COG0312	modulator of DNA gyrase
Theos_0564	COG1960	acyl-CoA dehydrogenase activity
Theos_0565	COG0456	acetyltransferase
Theos_0567	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Theos_0568	COG0009	L-threonylcarbamoyladenylate synthase
Theos_0573	COG0277	FAD linked oxidase domain protein
Theos_0574	COG3706	GGDEF domain
Theos_0575	COG0287	Prephenate dehydrogenase
Theos_0576	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Theos_0579	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Theos_0580	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Theos_0583	COG1609	Transcriptional regulator
Theos_0584	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Theos_0585	COG0179	Fumarylacetoacetate (FAA) hydrolase
Theos_0587	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Theos_0588	COG0151	Belongs to the GarS family
Theos_0589	COG2176	DNA-directed DNA polymerase activity
Theos_0589	COG5002	protein histidine kinase activity
Theos_0590	COG0745	RESPONSE REGULATOR receiver
Theos_0591	COG5002	protein histidine kinase activity
Theos_0595	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Theos_0597	COG0217	transcriptional regulatory protein
Theos_0598	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Theos_0598	COG4651	solute:proton antiporter activity
Theos_0599	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Theos_0600	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Theos_0602	COG1674	ftsk spoiiie
Theos_0605	COG0517	IMP dehydrogenase activity
Theos_0606	COG1605	Chorismate mutase
Theos_0606	COG0077	Prephenate dehydratase
Theos_0614	COG1744	ABC transporter substrate-binding protein PnrA-like
Theos_0616	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Theos_0617	COG0133	tryptophan synthase activity
Theos_0618	COG0159	tryptophan synthase activity
Theos_0619	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Theos_0626	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Theos_0627	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Theos_0633	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Theos_0635	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Theos_0636	COG2385	sporulation resulting in formation of a cellular spore
Theos_0637	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Theos_0639	COG0194	GDP metabolic process
Theos_0640	COG1758	RNA polymerase activity
Theos_0641	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Theos_0642	COG1438	arginine binding
Theos_0643	COG2095	MarC family integral membrane protein
Theos_0644	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Theos_0645	COG0328	RNA-DNA hybrid ribonuclease activity
Theos_0651	COG4274	PFAM GYD family protein
Theos_0652	COG0519	Catalyzes the synthesis of GMP from XMP
Theos_0652	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Theos_0653	COG1854	S-ribosylhomocysteine lyase activity
Theos_0654	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Theos_0655	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Theos_0656	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Theos_0657	COG0193	aminoacyl-tRNA hydrolase activity
Theos_0658	COG1181	Belongs to the D-alanine--D-alanine ligase family
Theos_0662	COG2255	four-way junction helicase activity
Theos_0663	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Theos_0667	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Theos_0668	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Theos_0669	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Theos_0670	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Theos_0672	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Theos_0673	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Theos_0674	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Theos_0678	COG1714	RDD family
Theos_0679	COG0616	signal peptide processing
Theos_0680	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Theos_0681	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Theos_0682	COG0443	Heat shock 70 kDa protein
Theos_0683	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Theos_0684	COG0484	heat shock protein binding
Theos_0685	COG0789	Transcriptional regulator
Theos_0686	COG0542	response to heat
Theos_0695	COG0490	domain, Protein
Theos_0696	COG0475	glutathione-regulated potassium exporter activity
Theos_0699	COG0516	GMP reductase activity
Theos_0699	COG0517	IMP dehydrogenase activity
Theos_0700	COG0475	glutathione-regulated potassium exporter activity
Theos_0702	COG0305	Participates in initiation and elongation during chromosome replication
Theos_0703	COG1007	ATP synthesis coupled electron transport
Theos_0704	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theos_0705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Theos_0706	COG0713	ATP synthesis coupled electron transport
Theos_0707	COG0839	Belongs to the complex I subunit 6 family
Theos_0708	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theos_0709	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Theos_0710	COG1034	ATP synthesis coupled electron transport
Theos_0711	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Theos_0712	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Theos_0713	COG0649	NAD binding
Theos_0714	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theos_0715	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theos_0716	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Theos_0717	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Theos_0719	COG4712	double-strand break repair protein
Theos_0728	COG0778	Nitroreductase
Theos_0729	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Theos_0730	COG0131	Imidazoleglycerol-phosphate dehydratase
Theos_0731	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Theos_0732	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Theos_0733	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Theos_0739	COG0861	Integral membrane protein TerC family
Theos_0740	COG2151	metal-sulfur cluster biosynthetic enzyme
Theos_0741	COG0281	malic enzyme
Theos_0744	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Theos_0745	COG0509	glycine decarboxylation via glycine cleavage system
Theos_0746	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Theos_0747	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Theos_0748	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theos_0750	COG0437	4 iron, 4 sulfur cluster binding
Theos_0751	COG0243	molybdopterin cofactor binding
Theos_0753	COG2197	response regulator
Theos_0754	COG3851	Histidine kinase
Theos_0755	COG0196	riboflavin kinase activity
Theos_0756	COG1051	belongs to the nudix hydrolase family
Theos_0758	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Theos_0761	COG2813	Specifically methylates the guanine in position
Theos_0762	COG0527	aspartate kinase activity
Theos_0763	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Theos_0764	COG0039	L-malate dehydrogenase activity
Theos_0767	COG4956	integral membrane protein (PIN domain superfamily)
Theos_0768	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Theos_0769	COG0542	response to heat
Theos_0770	COG0423	glycine-tRNA ligase activity
Theos_0771	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Theos_0775	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Theos_0775	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Theos_0776	COG1024	Enoyl-CoA hydratase
Theos_0777	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Theos_0778	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Theos_0779	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Theos_0781	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Theos_0782	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Theos_0783	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Theos_0785	COG0183	Belongs to the thiolase family
Theos_0788	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Theos_0789	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Theos_0793	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Theos_0794	COG1254	Belongs to the acylphosphatase family
Theos_0796	COG1063	alcohol dehydrogenase
Theos_0797	COG2133	pyrroloquinoline quinone binding
Theos_0799	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Theos_0800	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Theos_0805	COG0420	3'-5' exonuclease activity
Theos_0806	COG0419	ATPase involved in DNA repair
Theos_0808	COG0728	peptidoglycan biosynthetic process
Theos_0809	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Theos_0811	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Theos_0814	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Theos_0816	COG1269	ATP hydrolysis coupled proton transport
Theos_0818	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Theos_0819	COG1527	subunit (C
Theos_0820	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Theos_0821	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Theos_0822	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Theos_0823	COG1394	ATPase activity, coupled to movement of substances
Theos_0830	COG1337	RAMP superfamily
Theos_0834	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Theos_0837	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Theos_0838	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Theos_0839	COG1085	galactose-1-phosphate uridylyltransferase
Theos_0842	COG1126	abc transporter atp-binding protein
Theos_0851	COG1129	ABC transporter
Theos_0856	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Theos_0857	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Theos_0858	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theos_0858	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theos_0860	COG0793	Belongs to the peptidase S41A family
Theos_0861	COG2884	Cell division ATP-binding protein ftsE
Theos_0862	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Theos_0866	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theos_0869	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Theos_0870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Theos_0871	COG2719	SpoVR family
Theos_0873	COG2766	serine protein kinase
Theos_0875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Theos_0877	COG2137	regulation of response to DNA damage stimulus
Theos_0882	COG1692	metallophosphoesterase
Theos_0883	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Theos_0884	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Theos_0888	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Theos_0888	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Theos_0894	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Theos_0896	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Theos_0897	COG1397	ADP-ribosylglycohydrolase
Theos_0898	COG2239	Acts as a magnesium transporter
Theos_0900	COG0228	four-way junction DNA binding
Theos_0902	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Theos_0903	COG0336	Belongs to the RNA methyltransferase TrmD family
Theos_0904	COG0335	large ribosomal subunit rRNA binding
Theos_0905	COG2197	response regulator
Theos_0906	COG1760	l-serine dehydratase
Theos_0907	COG2897	thiosulfate sulfurtransferase activity
Theos_0908	COG2738	Putative neutral zinc metallopeptidase
Theos_0910	COG0450	alkyl hydroperoxide reductase
Theos_0912	COG1196	nuclear chromosome segregation
Theos_0915	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Theos_0917	COG1268	BioY protein
Theos_0920	COG0126	phosphoglycerate kinase activity
Theos_0921	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Theos_0922	COG0824	Thioesterase
Theos_0924	COG0557	exoribonuclease II activity
Theos_0925	COG1355	regulation of microtubule-based process
Theos_0926	COG0617	tRNA 3'-terminal CCA addition
Theos_0927	COG0237	dephospho-CoA kinase activity
Theos_0933	COG1857	crispr-associated protein
Theos_0937	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Theos_0940	COG0742	ribosomal rna small subunit methyltransferase
Theos_0941	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Theos_0942	COG0138	bifunctional purine biosynthesis protein purh
Theos_0943	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Theos_0944	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Theos_0953	COG0149	triose-phosphate isomerase activity
Theos_0954	COG3239	Fatty acid desaturase
Theos_0955	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Theos_0956	COG1490	D-aminoacyl-tRNA deacylase activity
Theos_0957	COG1307	EDD domain protein, DegV family
Theos_0958	COG1307	EDD domain protein, DegV family
Theos_0959	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Theos_0966	COG1136	(ABC) transporter
Theos_0969	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Theos_0971	COG1012	belongs to the aldehyde dehydrogenase family
Theos_0972	COG2368	4-hydroxyphenylacetate
Theos_0973	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Theos_0977	COG0411	ABC transporter
Theos_0979	COG2050	protein possibly involved in aromatic compounds catabolism
Theos_0980	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Theos_0983	COG0477	Major facilitator Superfamily
Theos_0984	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Theos_0990	COG3396	Phenylacetate-CoA oxygenase
Theos_0994	COG2030	dehydratase
Theos_0994	COG1012	belongs to the aldehyde dehydrogenase family
Theos_0995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Theos_1000	COG1404	Belongs to the peptidase S8 family
Theos_1004	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
Theos_1005	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Theos_1007	COG0183	Belongs to the thiolase family
Theos_1008	COG1331	Highly conserved protein containing a thioredoxin domain
Theos_1011	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Theos_1013	COG2193	ferroxidase activity
Theos_1014	COG1733	regulation of RNA biosynthetic process
Theos_1016	COG1980	fructose-bisphosphate aldolase activity
Theos_1017	COG4974	Belongs to the 'phage' integrase family
Theos_1018	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Theos_1020	COG1111	helicase
Theos_1020	COG1205	dead DEAH box helicase
Theos_1021	COG0497	DNA recombination
Theos_1024	COG1960	acyl-CoA dehydrogenase activity
Theos_1025	COG2199	diguanylate cyclase activity
Theos_1028	COG2151	metal-sulfur cluster biosynthetic enzyme
Theos_1032	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Theos_1038	COG2181	nitrate reductase activity
Theos_1041	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Theos_1044	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Theos_1046	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Theos_1050	COG1252	NADH dehydrogenase
Theos_1052	COG2010	Cytochrome c
Theos_1054	COG2832	Protein of unknown function (DUF454)
Theos_1057	COG2010	Cytochrome c
Theos_1063	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Theos_1064	COG3191	aminopeptidase activity
Theos_1067	COG0714	Associated with various cellular activities
Theos_1069	COG2304	oxidoreductase activity
Theos_1070	COG2304	oxidoreductase activity
Theos_1072	COG4221	oxidoreductase activity
Theos_1074	COG2873	o-acetylhomoserine
Theos_1075	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Theos_1078	COG0405	Gamma-glutamyltransferase
Theos_1082	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_1085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theos_1087	COG1940	carbohydrate kinase activity
Theos_1097	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Theos_1098	COG2264	protein methyltransferase activity
Theos_1100	COG0489	protein tyrosine kinase activity
Theos_1108	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Theos_1109	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Theos_1111	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Theos_1112	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Theos_1118	COG2001	Belongs to the MraZ family
Theos_1119	COG0275	rRNA processing
Theos_1122	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Theos_1124	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Theos_1125	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Theos_1126	COG0772	Belongs to the SEDS family
Theos_1127	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Theos_1128	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Theos_1129	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Theos_1133	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Theos_1140	COG2391	methyltransferase activity
Theos_1143	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Theos_1145	COG1562	ergosterol biosynthetic process
Theos_1146	COG0415	Belongs to the DNA photolyase family
Theos_1151	COG0463	Glycosyl transferase, family 2
Theos_1152	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Theos_1153	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Theos_1155	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Theos_1156	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Theos_1157	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Theos_1159	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Theos_1162	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Theos_1163	COG2304	oxidoreductase activity
Theos_1164	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Theos_1164	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Theos_1167	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Theos_1167	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Theos_1168	COG0779	Required for maturation of 30S ribosomal subunits
Theos_1169	COG0195	Participates in both transcription termination and antitermination
Theos_1170	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Theos_1172	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Theos_1172	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Theos_1173	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Theos_1175	COG0183	Belongs to the thiolase family
Theos_1176	COG1960	acyl-CoA dehydrogenase activity
Theos_1178	COG1752	Esterase of the alpha-beta hydrolase superfamily
Theos_1179	COG3311	Transcriptional regulator
Theos_1181	COG0134	indole-3-glycerol-phosphate synthase activity
Theos_1182	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Theos_1184	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Theos_1186	COG0525	valine-tRNA ligase activity
Theos_1187	COG0765	amino acid transport
Theos_1188	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Theos_1190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Theos_1191	COG0569	domain protein
Theos_1192	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Theos_1194	COG2313	pseudouridylate synthase activity
Theos_1197	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Theos_1198	COG4585	Histidine kinase
Theos_1199	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Theos_1200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Theos_1200	COG4499	WXG100 protein secretion system (Wss), protein YukC
Theos_1203	COG0012	GTP binding
Theos_1204	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Theos_1206	COG0424	maF-like protein
Theos_1209	COG0768	penicillin binding
Theos_1217	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Theos_1218	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Theos_1220	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Theos_1222	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Theos_1224	COG4555	ABC transporter
Theos_1227	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Theos_1229	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Theos_1230	COG0440	acetolactate synthase activity
Theos_1231	COG0028	Belongs to the TPP enzyme family
Theos_1232	COG0492	ferredoxin-NADP+ reductase activity
Theos_1233	COG0861	Integral membrane protein TerC family
Theos_1240	COG2165	general secretion pathway protein
Theos_1244	COG4636	protein conserved in cyanobacteria
Theos_1247	COG0180	Tryptophanyl-tRNA synthetase
Theos_1249	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Theos_1250	COG0066	3-isopropylmalate dehydratase activity
Theos_1251	COG0473	3-isopropylmalate dehydrogenase activity
Theos_1254	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_1255	COG0129	dihydroxy-acid dehydratase activity
Theos_1256	COG2010	Cytochrome c
Theos_1257	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Theos_1258	COG1177	transmembrane transport
Theos_1259	COG1176	ABC-type spermidine putrescine transport system, permease component I
Theos_1260	COG3842	ATPase activity
Theos_1261	COG0772	Belongs to the SEDS family
Theos_1262	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Theos_1263	COG2894	cell division
Theos_1264	COG1733	regulation of RNA biosynthetic process
Theos_1268	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Theos_1269	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Theos_1270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Theos_1271	COG0653	protein targeting
Theos_1272	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Theos_1276	COG1111	helicase
Theos_1276	COG1205	dead DEAH box helicase
Theos_1279	COG0358	DNA primase activity
Theos_1281	COG1250	3-hydroxyacyl-CoA dehydrogenase
Theos_1282	COG0697	spore germination
Theos_1283	COG0612	Peptidase, M16
Theos_1284	COG0612	Peptidase, M16
Theos_1285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Theos_1289	COG0300	oxidoreductase activity
Theos_1290	COG0673	inositol 2-dehydrogenase activity
Theos_1292	COG1070	Carbohydrate kinase
Theos_1295	COG1129	ABC transporter
Theos_1296	COG4214	carbohydrate transport
Theos_1297	COG4213	ABC transporter substrate-binding protein
Theos_1302	COG0582	viral genome integration into host DNA
Theos_1312	COG0582	viral genome integration into host DNA
Theos_1322	COG2189	Belongs to the N(4) N(6)-methyltransferase family
Theos_1326	COG0582	viral genome integration into host DNA
Theos_1328	COG0052	Belongs to the universal ribosomal protein uS2 family
Theos_1329	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Theos_1330	COG0528	UMP kinase activity
Theos_1331	COG0233	cytoplasmic translational termination
Theos_1332	COG4589	Belongs to the CDS family
Theos_1333	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Theos_1337	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Theos_1338	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Theos_1339	COG2359	stage V sporulation protein S
Theos_1340	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Theos_1342	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Theos_1344	COG0646	methionine synthase
Theos_1344	COG1410	methionine synthase
Theos_1345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Theos_1346	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Theos_1347	COG0740	serine-type endopeptidase activity
Theos_1348	COG0544	peptidyl-prolyl cis-trans isomerase activity
Theos_1352	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Theos_1353	COG3870	Protein conserved in bacteria
Theos_1354	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Theos_1356	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Theos_1360	COG1309	transcriptional regulator
Theos_1361	COG1960	acyl-CoA dehydrogenase activity
Theos_1362	COG2030	dehydratase
Theos_1362	COG1012	belongs to the aldehyde dehydrogenase family
Theos_1364	COG0318	PFAM AMP-dependent synthetase and ligase
Theos_1365	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_1367	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Theos_1368	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Theos_1369	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Theos_1372	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Theos_1374	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Theos_1375	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Theos_1377	COG3383	formate dehydrogenase (NAD+) activity
Theos_1378	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Theos_1381	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Theos_1383	COG0165	Argininosuccinate lyase
Theos_1386	COG0410	ABC transporter
Theos_1388	COG1022	Amp-dependent synthetase and ligase
Theos_1390	COG4475	Protein of unknown function (DUF436)
Theos_1393	COG1970	mechanosensitive ion channel activity
Theos_1394	COG3842	ATPase activity
Theos_1395	COG0572	uridine kinase
Theos_1399	COG2176	DNA-directed DNA polymerase activity
Theos_1400	COG0154	amidase activity
Theos_1401	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Theos_1403	COG1435	thymidine kinase activity
Theos_1404	COG0254	rRNA binding
Theos_1406	COG4864	UPF0365 protein
Theos_1408	COG1702	phosphate starvation-inducible protein PhoH
Theos_1409	COG0481	GTPase activity
Theos_1411	COG1760	l-serine dehydratase
Theos_1413	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Theos_1421	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Theos_1424	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Theos_1427	COG1316	TRANSCRIPTIONal
Theos_1430	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Theos_1434	COG1573	uracil-dna glycosylase
Theos_1437	COG3842	ATPase activity
Theos_1440	COG0124	histidyl-tRNA synthetase
Theos_1441	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Theos_1442	COG0384	phenazine biosynthesis protein PhzF
Theos_1443	COG0561	phosphatase activity
Theos_1444	COG0017	Asparaginyl-tRNA synthetase
Theos_1445	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Theos_1453	COG0702	epimerase
Theos_1461	COG0640	Transcriptional regulator
Theos_1462	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Theos_1464	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Theos_1465	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Theos_1466	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Theos_1467	COG0006	proline dipeptidase activity
Theos_1468	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Theos_1469	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Theos_1470	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Theos_1471	COG1994	Peptidase M50
Theos_1473	COG0617	tRNA 3'-terminal CCA addition
Theos_1475	COG0438	transferase activity, transferring glycosyl groups
Theos_1476	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Theos_1478	COG2819	hydrolase of the alpha beta superfamily
Theos_1479	COG0861	Integral membrane protein TerC family
Theos_1481	COG2181	nitrate reductase activity
Theos_1481	COG0247	lactate metabolic process
Theos_1483	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Theos_1484	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Theos_1485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Theos_1487	COG0439	Biotin carboxylase
Theos_1488	COG0511	ligase activity, forming carbon-carbon bonds
Theos_1489	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Theos_1493	COG0010	Belongs to the arginase family
Theos_1496	COG1100	Small GTP-binding protein
Theos_1498	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Theos_1499	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Theos_1501	COG2814	Major facilitator Superfamily
Theos_1502	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Theos_1503	COG1185	polyribonucleotide nucleotidyltransferase activity
Theos_1504	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Theos_1506	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Theos_1507	COG0745	RESPONSE REGULATOR receiver
Theos_1508	COG5002	protein histidine kinase activity
Theos_1509	COG1960	acyl-CoA dehydrogenase activity
Theos_1510	COG2086	electron transfer activity
Theos_1511	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Theos_1513	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Theos_1514	COG1573	uracil-dna glycosylase
Theos_1515	COG1796	DNA polymerase
Theos_1515	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Theos_1518	COG1013	pyruvate-flavodoxin oxidoreductase activity
Theos_1518	COG0674	pyruvate-flavodoxin oxidoreductase activity
Theos_1518	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Theos_1518	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Theos_1523	COG2873	o-acetylhomoserine
Theos_1525	COG0300	oxidoreductase activity
Theos_1527	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Theos_1528	COG0215	cysteine-tRNA ligase activity
Theos_1529	COG1960	acyl-CoA dehydrogenase activity
Theos_1530	COG0183	Belongs to the thiolase family
Theos_1531	COG1024	Enoyl-CoA hydratase
Theos_1531	COG1250	3-hydroxyacyl-CoA dehydrogenase
Theos_1536	COG0318	PFAM AMP-dependent synthetase and ligase
Theos_1539	COG1063	alcohol dehydrogenase
Theos_1540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Theos_1541	COG1012	belongs to the aldehyde dehydrogenase family
Theos_1542	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Theos_1545	COG0438	transferase activity, transferring glycosyl groups
Theos_1547	COG1216	Glycosyl transferase, family 2
Theos_1549	COG1216	Glycosyl transferase, family 2
Theos_1552	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Theos_1552	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Theos_1553	COG1811	Na channel or pump
Theos_1554	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Theos_1555	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Theos_1556	COG4948	Mandelate Racemase Muconate Lactonizing
Theos_1558	COG0402	S-adenosylhomocysteine deaminase activity
Theos_1562	COG1012	belongs to the aldehyde dehydrogenase family
Theos_1563	COG0506	proline dehydrogenase activity
Theos_1564	COG1802	Transcriptional regulator
Theos_1568	COG0156	8-amino-7-oxononanoate synthase activity
Theos_1571	COG0187	DNA topoisomerase II activity
Theos_1572	COG1643	Atp-dependent helicase
Theos_1575	COG1063	alcohol dehydrogenase
Theos_1581	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_1586	COG1605	Chorismate mutase
Theos_1586	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Theos_1587	COG0805	protein transport
Theos_1588	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Theos_1589	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Theos_1590	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Theos_1593	COG0686	Belongs to the AlaDH PNT family
Theos_1594	COG0427	acetyl-CoA hydrolase
Theos_1595	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Theos_1596	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Theos_1596	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Theos_1597	COG0083	homoserine kinase activity
Theos_1600	COG0268	Binds directly to 16S ribosomal RNA
Theos_1602	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Theos_1606	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Theos_1607	COG1138	Cytochrome C-type biogenesis protein
Theos_1608	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Theos_1610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Theos_1611	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Theos_1612	COG1131	(ABC) transporter
Theos_1613	COG0785	Cytochrome C biogenesis protein
Theos_1615	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Theos_1616	COG0446	pyridine nucleotide-disulphide oxidoreductase
Theos_1619	COG3258	Cytochrome c
Theos_1620	COG2010	Cytochrome c
Theos_1621	COG0737	Belongs to the 5'-nucleotidase family
Theos_1622	COG2010	Cytochrome c
Theos_1623	COG3258	Cytochrome c
Theos_1627	COG2010	Cytochrome c
Theos_1628	COG3842	ATPase activity
Theos_1632	COG0517	IMP dehydrogenase activity
Theos_1632	COG0516	GMP reductase activity
Theos_1633	COG2814	Major facilitator Superfamily
Theos_1634	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theos_1637	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Theos_1640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Theos_1641	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Theos_1642	COG0107	imidazoleglycerol-phosphate synthase activity
Theos_1643	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Theos_1643	COG0140	phosphoribosyl-ATP diphosphatase activity
Theos_1644	COG1494	fructose-1,6-bisphosphatase
Theos_1649	COG0395	ABC-type sugar transport system, permease component
Theos_1650	COG1175	transmembrane transport
Theos_1654	COG0084	hydrolase, TatD family'
Theos_1657	COG0017	Asparaginyl-tRNA synthetase
Theos_1658	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Theos_1661	COG2009	succinate dehydrogenase
Theos_1662	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Theos_1668	COG0318	PFAM AMP-dependent synthetase and ligase
Theos_1669	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Theos_1670	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Theos_1671	COG0504	CTP synthase activity
Theos_1674	COG0070	glutamate synthase
Theos_1674	COG0069	glutamate synthase activity
Theos_1674	COG0067	glutamate synthase
Theos_1680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Theos_1681	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Theos_1682	COG0823	Involved in the tonB-independent uptake of proteins
Theos_1682	COG1506	peptidase
Theos_1682	COG4946	Tricorn protease homolog
Theos_1684	COG0037	tRNA processing
Theos_1684	COG0590	tRNA wobble adenosine to inosine editing
Theos_1703	COG0538	isocitrate dehydrogenase activity
Theos_1704	COG0557	exoribonuclease II activity
Theos_1706	COG0585	pseudouridine synthase activity
Theos_1710	COG2050	protein possibly involved in aromatic compounds catabolism
Theos_1711	COG0322	excinuclease ABC activity
Theos_1713	COG0018	arginyl-trna synthetase
Theos_1715	COG1428	Deoxynucleoside kinase
Theos_1717	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Theos_1720	COG2081	HI0933 family
Theos_1723	COG0463	Glycosyl transferase, family 2
Theos_1725	COG0745	RESPONSE REGULATOR receiver
Theos_1726	COG5002	protein histidine kinase activity
Theos_1729	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Theos_1731	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Theos_1732	COG0572	uridine kinase
Theos_1737	COG0583	DNA-binding transcription factor activity
Theos_1743	COG0191	fructose-bisphosphate aldolase activity
Theos_1744	COG2045	Belongs to the ComB family
Theos_1747	COG0513	Belongs to the DEAD box helicase family
Theos_1748	COG0303	'Molybdopterin
Theos_1752	COG1116	anion transmembrane transporter activity
Theos_1753	COG0442	prolyl-tRNA aminoacylation
Theos_1756	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Theos_1757	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Theos_1759	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_1761	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Theos_1761	COG1213	nucleotidyl transferase
Theos_1762	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Theos_1763	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Theos_1764	COG1104	cysteine desulfurase activity
Theos_1765	COG1959	2 iron, 2 sulfur cluster binding
Theos_1766	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Theos_1767	COG1121	(ABC) transporter
Theos_1768	COG0410	ABC transporter
Theos_1772	COG0318	PFAM AMP-dependent synthetase and ligase
Theos_1776	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Theos_1777	COG0706	membrane insertase activity
Theos_1778	COG1837	Belongs to the UPF0109 family
Theos_1779	COG2890	protein-(glutamine-N5) methyltransferase activity
Theos_1782	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Theos_1785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Theos_1789	COG0318	PFAM AMP-dependent synthetase and ligase
Theos_1790	COG3360	Dodecin
Theos_1793	COG1024	Enoyl-CoA hydratase
Theos_1794	COG0813	purine-nucleoside phosphorylase activity
Theos_1795	COG1136	(ABC) transporter
Theos_1796	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Theos_1797	COG2045	Belongs to the ComB family
Theos_1798	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Theos_1799	COG0789	Transcriptional regulator
Theos_1800	COG1414	Transcriptional regulator
Theos_1803	COG0277	FAD linked oxidase domain protein
Theos_1804	COG0277	FAD linked oxidase domain protein
Theos_1805	COG0247	lactate metabolic process
Theos_1809	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Theos_1818	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Theos_1819	COG0460	homoserine dehydrogenase
Theos_1820	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Theos_1822	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Theos_1824	COG2226	methyltransferase
Theos_1825	COG2226	methyltransferase
Theos_1826	COG0366	Alpha amylase catalytic
Theos_1828	COG0037	tRNA processing
Theos_1829	COG2104	thiamine diphosphate biosynthetic process
Theos_1830	COG0123	including yeast histone deacetylase and acetoin utilization protein
Theos_1831	COG0517	IMP dehydrogenase activity
Theos_1833	COG0444	Belongs to the ABC transporter superfamily
Theos_1834	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Theos_1835	COG0601	transmembrane transport
Theos_1836	COG0747	negative chemotaxis
Theos_1838	COG0492	ferredoxin-NADP+ reductase activity
Theos_1849	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Theos_1851	COG2414	aldehyde ferredoxin oxidoreductase
Theos_1858	COG1902	pentaerythritol trinitrate reductase activity
Theos_1861	COG0495	leucyl-tRNA aminoacylation
Theos_1862	COG0539	negative regulation of cytoplasmic translation
Theos_1862	COG2183	response to ionizing radiation
Theos_1865	COG1694	Mazg nucleotide pyrophosphohydrolase
Theos_1866	COG1803	Methylglyoxal synthase
Theos_1867	COG0154	amidase activity
Theos_1872	COG0667	Aldo Keto reductase
Theos_1875	COG1067	ATP-dependent peptidase activity
Theos_1876	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Theos_1878	COG0745	RESPONSE REGULATOR receiver
Theos_1880	COG0297	glycogen (starch) synthase activity
Theos_1882	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Theos_1883	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Theos_1888	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Theos_1898	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Theos_1899	COG2860	membrane
Theos_1900	COG0315	cyclic pyranopterin monophosphate synthase activity
Theos_1907	COG0735	belongs to the Fur family
Theos_1908	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Theos_1909	COG3872	metal-dependent enzyme
Theos_1910	COG0482	sulfurtransferase activity
Theos_1911	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Theos_1912	COG0573	inorganic phosphate transmembrane transporter activity
Theos_1914	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Theos_1915	COG2814	Major facilitator Superfamily
Theos_1916	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Theos_1918	COG0791	NLP P60 protein
Theos_1918	COG1388	LysM domain
Theos_1919	COG0778	Nitroreductase
Theos_1920	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Theos_1921	COG1960	acyl-CoA dehydrogenase activity
Theos_1922	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Theos_1924	COG0445	tRNA wobble uridine modification
Theos_1928	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Theos_1929	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Theos_1929	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Theos_1930	COG1543	Belongs to the glycosyl hydrolase 57 family
Theos_1931	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Theos_1932	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Theos_1933	COG0189	ligase activity
Theos_1936	COG0066	3-isopropylmalate dehydratase activity
Theos_1937	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Theos_1941	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Theos_1942	COG1960	acyl-CoA dehydrogenase activity
Theos_1943	COG0163	prenyltransferase activity
Theos_1944	COG0222	ribosome binding
Theos_1945	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Theos_1946	COG0081	regulation of translation
Theos_1947	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Theos_1948	COG0250	Participates in transcription elongation, termination and antitermination
Theos_1949	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Theos_1950	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Theos_1956	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Theos_1957	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Theos_1959	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Theos_1961	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Theos_1963	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Theos_1964	COG1993	acr, cog1993
Theos_1965	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Theos_1966	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Theos_1969	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Theos_1972	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Theos_1978	COG1842	Phage shock protein A
Theos_1982	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Theos_1983	COG1774	PSP1 C-terminal conserved region
Theos_1987	COG2226	methyltransferase
Theos_1988	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Theos_1991	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Theos_1992	COG0512	Glutamine amidotransferase of anthranilate synthase
Theos_1993	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Theos_1994	COG2010	Cytochrome c
Theos_1998	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Theos_2002	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Theos_2007	COG1597	lipid kinase activity
Theos_2008	COG0406	alpha-ribazole phosphatase activity
Theos_2010	COG0123	including yeast histone deacetylase and acetoin utilization protein
Theos_2012	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Theos_2014	COG0004	ammonium transporteR
Theos_2015	COG0347	Belongs to the P(II) protein family
Theos_2016	COG1420	regulation of RNA biosynthetic process
Theos_2017	COG0314	molybdopterin synthase activity
Theos_2020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Theos_2021	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Theos_2023	COG2154	pterin-4-alpha-carbinolamine dehydratase
Theos_2024	COG1607	acyl-coa hydrolase
Theos_2026	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Theos_2027	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Theos_2028	COG1185	polyribonucleotide nucleotidyltransferase activity
Theos_2030	COG0416	fatty acid biosynthetic process
Theos_2031	COG1371	PFAM Archease protein family (DUF101 UPF0211)
Theos_2032	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Theos_2036	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Theos_2037	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Theos_2041	COG2096	Adenosyltransferase
Theos_2043	COG4555	ABC transporter
Theos_2048	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Theos_2051	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Theos_2052	COG3706	GGDEF domain
Theos_2054	COG1252	NADH dehydrogenase
Theos_2059	COG0437	4 iron, 4 sulfur cluster binding
Theos_2062	COG0802	atpase or kinase
Theos_2063	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Theos_2064	COG2389	metal-binding protein
Theos_2065	COG4242	Belongs to the peptidase S51 family
Theos_2066	COG1309	transcriptional regulator
Theos_2069	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Theos_2070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Theos_2071	COG1968	undecaprenyl-diphosphatase activity
Theos_2072	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Theos_2073	COG0484	heat shock protein binding
Theos_2074	COG1278	Cold shock
Theos_2076	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Theos_2083	COG0358	DNA primase activity
Theos_2091	COG0321	lipoyl(octanoyl) transferase activity
Theos_2092	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Theos_2095	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Theos_2098	COG1598	PFAM Uncharacterised protein family UPF0150
Theos_2099	COG0022	dehydrogenase e1 component
Theos_2100	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Theos_2101	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Theos_2108	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Theos_2110	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Theos_2112	COG1187	pseudouridine synthase activity
Theos_2113	COG1024	Enoyl-CoA hydratase
Theos_2114	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Theos_2115	COG0686	Belongs to the AlaDH PNT family
Theos_2116	COG1302	Protein conserved in bacteria
Theos_2117	COG1461	Dihydroxyacetone kinase
Theos_2121	COG0359	binds to the 23S rRNA
Theos_2122	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Theos_2124	COG0360	Binds together with S18 to 16S ribosomal RNA
Theos_2126	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Theos_2127	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Theos_2128	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Theos_2133	COG0243	molybdopterin cofactor binding
Theos_2135	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Theos_2137	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Theos_2140	COG0477	Major facilitator Superfamily
Theos_2143	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Theos_2151	COG0535	radical SAM domain protein
Theos_2156	COG0105	UTP biosynthetic process
Theos_2157	COG0631	protein serine/threonine phosphatase activity
Theos_2158	COG0583	DNA-binding transcription factor activity
Theos_2159	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Theos_2160	COG0508	dehydrogenase complex catalyzes the overall conversion of
Theos_2161	COG1653	transport
Theos_2167	COG2223	nitrite transmembrane transporter activity
Theos_2169	COG0517	IMP dehydrogenase activity
Theos_2169	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Theos_2170	COG1950	PFAM Membrane protein of
Theos_2171	COG1309	transcriptional regulator
Theos_2172	COG1131	(ABC) transporter
Theos_2173	COG0842	Transport permease protein
Theos_2176	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Theos_2178	COG1278	Cold shock
Theos_2179	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Theos_2183	COG0521	Mo-molybdopterin cofactor biosynthetic process
Theos_2184	COG0436	Aminotransferase
Theos_2185	COG0285	dihydrofolate synthase activity
Theos_2186	COG0735	belongs to the Fur family
Theos_2187	COG0181	hydroxymethylbilane synthase activity
Theos_2192	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Theos_2193	COG0072	phenylalanine-tRNA ligase activity
Theos_2193	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Theos_2195	COG0205	6-phosphofructokinase activity
Theos_2196	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Theos_2198	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Theos_2202	COG0658	competence protein
Theos_2202	COG2333	competence protein COMEC
Theos_2203	COG1475	DNA binding
Theos_2204	COG1192	Involved in chromosome partitioning
Theos_2205	COG0357	Ribosomal RNA small subunit methyltransferase G
Theos_2206	COG0445	tRNA wobble uridine modification
Theos_2218	COG1129	ABC transporter
Theos_2219	COG4638	Rieske (2fe-2S)
Theos_2220	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
Theos_2226	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Theos_2227	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Theos_2229	COG2186	Transcriptional regulator
Theos_2231	COG1012	belongs to the aldehyde dehydrogenase family
Theos_2233	COG0559	Belongs to the binding-protein-dependent transport system permease family
Theos_2234	COG0411	ABC transporter
Theos_2257	COG3335	DDE superfamily endonuclease
Theos_2265	COG4974	Belongs to the 'phage' integrase family
Theos_2270	COG2255	four-way junction helicase activity
Theos_2285	COG2723	6-phospho-beta-galactosidase activity
Theos_2287	COG1175	transmembrane transport
Theos_2289	COG1609	Transcriptional regulator
Theos_2290	COG0352	thiamine-phosphate diphosphorylase activity
Theos_2290	COG0351	phosphomethylpyrimidine kinase
Theos_2292	COG0477	Major facilitator Superfamily
Theos_2293	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Theos_2295	COG2022	thiamine diphosphate biosynthetic process
Theos_2296	COG2104	thiamine diphosphate biosynthetic process
Theos_2297	COG0352	thiamine-phosphate diphosphorylase activity
Theos_2298	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Theos_2299	COG1587	Uroporphyrinogen-III synthase
Theos_2300	COG1648	precorrin-2 dehydrogenase activity
Theos_2300	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Theos_2301	COG0175	sulfate reduction
Theos_2302	COG0730	response to heat
Theos_2303	COG1648	precorrin-2 dehydrogenase activity
Theos_2303	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Theos_2304	COG2046	Belongs to the sulfate adenylyltransferase family
Theos_2305	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Theos_2306	COG1797	cobyrinic acid a,c-diamide synthase activity
Theos_2311	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Theos_2312	COG0393	Putative heavy-metal-binding
Theos_2314	COG0588	phosphoglycerate mutase activity
Theos_2315	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Theos_2316	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Theos_2325	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Theos_2325	COG1648	precorrin-2 dehydrogenase activity
Theos_2326	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Theos_2331	COG1492	cobalamin metabolic process
Theos_2332	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_2333	COG0410	ABC transporter
Theos_2341	COG1785	Belongs to the alkaline phosphatase family
Theos_2346	COG0395	ABC-type sugar transport system, permease component
Theos_2347	COG1175	transmembrane transport
Theos_2349	COG1607	acyl-coa hydrolase
Theos_2358	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Theos_2360	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Theos_2361	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Theos_2362	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Theos_2365	COG2205	protein histidine kinase activity
Theos_2366	COG0745	RESPONSE REGULATOR receiver
Theos_2372	COG1595	DNA-templated transcription, initiation
Theos_2379	COG0803	Belongs to the bacterial solute-binding protein 9 family
Theos_2381	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Theos_2382	COG0248	Ppx GppA phosphatase
Theos_2386	COG2062	phosphohistidine phosphatase, SixA
Theos_2390	COG1653	transport
Theos_2391	COG1175	transmembrane transport
Theos_2392	COG0395	ABC-type sugar transport system, permease component
Theos_2393	COG1692	metallophosphoesterase
Theos_2396	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Theos_2399	COG0800	Aldolase
Theos_2400	COG1414	Transcriptional regulator
Theos_2402	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_2404	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Theos_2405	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_2408	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Theos_2412	COG1192	Involved in chromosome partitioning
Theos_2413	COG1475	DNA binding
Theos_2414	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Theos_2426	COG5001	Diguanylate cyclase
Theos_2428	COG0747	negative chemotaxis
Theos_2429	COG0601	transmembrane transport
Theos_2431	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
Theos_2432	COG0019	diaminopimelate decarboxylase activity
Theos_2433	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Theos_2435	COG1486	melibiose metabolic process
Theos_2440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Theos_2441	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Theos_2443	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Theos_2448	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Theos_2450	COG1012	belongs to the aldehyde dehydrogenase family
Theos_2456	COG0789	Transcriptional regulator
Theos_2457	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Theos_2458	COG1028	Short-chain dehydrogenase reductase Sdr
Theos_2460	COG0559	Belongs to the binding-protein-dependent transport system permease family
Theos_2464	COG2182	Extracellular solute-binding protein
Theos_2466	COG0395	ABC-type sugar transport system, permease component
Theos_2472	COG1942	4-Oxalocrotonate Tautomerase
Theos_2477	COG1525	nuclease
Theos_2545	COG1404	Belongs to the peptidase S8 family
Theos_2546	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Theos_2547	COG1192	Involved in chromosome partitioning
Theos_2548	COG1475	DNA binding
Theos_2551	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Theos_2551	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair