locus-tag	class	description
TSC_c00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TSC_c00020	COG0592	DNA-directed DNA polymerase activity
TSC_c00030	COG0148	phosphopyruvate hydratase activity
TSC_c00090	COG0631	protein serine/threonine phosphatase activity
TSC_c00100	COG0105	UTP biosynthetic process
TSC_c00120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TSC_c00180	COG0315	cyclic pyranopterin monophosphate synthase activity
TSC_c00210	COG2010	Cytochrome c
TSC_c00240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSC_c00250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TSC_c00270	COG1842	Phage shock protein A
TSC_c00290	COG1131	(ABC) transporter
TSC_c00300	COG0842	Transport permease protein
TSC_c00330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TSC_c00360	COG1278	Cold shock
TSC_c00370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TSC_c00400	COG2860	membrane
TSC_c00410	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TSC_c00500	COG2414	aldehyde ferredoxin oxidoreductase
TSC_c00590	COG1131	(ABC) transporter
TSC_c00640	COG3956	TIGRFAM MazG family protein
TSC_c00660	COG0693	protein deglycase activity
TSC_c00670	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TSC_c00690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TSC_c00720	COG1937	Protein conserved in bacteria
TSC_c00740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSC_c00740	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSC_c00750	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSC_c00810	COG0459	protein refolding
TSC_c00820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TSC_c00840	COG0714	Associated with various cellular activities
TSC_c00870	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSC_c00890	COG0166	Belongs to the GPI family
TSC_c00900	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TSC_c00910	COG1612	heme a metabolic process
TSC_c00910	COG0109	protoheme IX farnesyltransferase activity
TSC_c00930	COG1845	cytochrome c oxidase, subunit III
TSC_c00930	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSC_c00970	COG1845	cytochrome c oxidase, subunit III
TSC_c00990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSC_c01000	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSC_c01050	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TSC_c01060	COG2814	Major facilitator Superfamily
TSC_c01070	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TSC_c01080	COG0581	inorganic phosphate transmembrane transporter activity
TSC_c01090	COG0573	inorganic phosphate transmembrane transporter activity
TSC_c01110	COG0482	sulfurtransferase activity
TSC_c01150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TSC_c01160	COG0735	belongs to the Fur family
TSC_c01190	COG0583	DNA-binding transcription factor activity
TSC_c01200	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TSC_c01210	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSC_c01220	COG0181	hydroxymethylbilane synthase activity
TSC_c01240	COG0285	dihydrofolate synthase activity
TSC_c01250	COG0436	Aminotransferase
TSC_c01260	COG0521	Mo-molybdopterin cofactor biosynthetic process
TSC_c01290	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TSC_c01300	COG0154	amidase activity
TSC_c01310	COG0301	tRNA thio-modification
TSC_c01330	COG0243	molybdopterin cofactor binding
TSC_c01350	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TSC_c01370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSC_c01380	COG1653	transport
TSC_c01410	COG0033	Phosphoglucomutase
TSC_c01420	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSC_c01440	COG2814	Major facilitator Superfamily
TSC_c01460	COG0516	GMP reductase activity
TSC_c01460	COG0517	IMP dehydrogenase activity
TSC_c01470	COG1950	PFAM Membrane protein of
TSC_c01510	COG0406	alpha-ribazole phosphatase activity
TSC_c01520	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TSC_c01530	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSC_c01550	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TSC_c01560	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TSC_c01590	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TSC_c01600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TSC_c01610	COG1993	acr, cog1993
TSC_c01620	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSC_c01640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TSC_c01660	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TSC_c01670	COG1335	isochorismatase
TSC_c01680	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TSC_c01690	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TSC_c01750	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TSC_c01760	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TSC_c01770	COG0250	Participates in transcription elongation, termination and antitermination
TSC_c01780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TSC_c01790	COG0081	regulation of translation
TSC_c01800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TSC_c01810	COG0222	ribosome binding
TSC_c01820	COG0163	prenyltransferase activity
TSC_c01830	COG1960	acyl-CoA dehydrogenase activity
TSC_c01840	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TSC_c01880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSC_c01890	COG0066	3-isopropylmalate dehydratase activity
TSC_c01920	COG0189	ligase activity
TSC_c01930	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TSC_c01940	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TSC_c01950	COG1543	Belongs to the glycosyl hydrolase 57 family
TSC_c01960	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSC_c01960	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSC_c01970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TSC_c02000	COG0445	tRNA wobble uridine modification
TSC_c02020	COG1388	LysM domain
TSC_c02020	COG0791	NLP P60 protein
TSC_c02030	COG0778	Nitroreductase
TSC_c02040	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TSC_c02060	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TSC_c02070	COG0477	Major facilitator Superfamily
TSC_c02100	COG1694	Mazg nucleotide pyrophosphohydrolase
TSC_c02130	COG1803	Methylglyoxal synthase
TSC_c02150	COG2271	Major facilitator Superfamily
TSC_c02180	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TSC_c02190	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TSC_c02200	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TSC_c02220	COG0360	Binds together with S18 to 16S ribosomal RNA
TSC_c02240	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TSC_c02250	COG0359	binds to the 23S rRNA
TSC_c02260	COG0300	oxidoreductase activity
TSC_c02280	COG0321	lipoyl(octanoyl) transferase activity
TSC_c02290	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TSC_c02350	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TSC_c02380	COG1598	PFAM Uncharacterised protein family UPF0150
TSC_c02390	COG0022	dehydrogenase e1 component
TSC_c02400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TSC_c02410	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TSC_c02450	COG2226	methyltransferase
TSC_c02460	COG0432	Pfam Uncharacterised protein family UPF0047
TSC_c02480	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TSC_c02500	COG0668	transmembrane transport
TSC_c02570	COG0642	Histidine kinase
TSC_c02600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TSC_c02610	COG1136	(ABC) transporter
TSC_c02620	COG1136	(ABC) transporter
TSC_c02620	COG0577	efflux transmembrane transporter activity
TSC_c02640	COG0632	four-way junction helicase activity
TSC_c02650	COG1024	Enoyl-CoA hydratase
TSC_c02690	COG0508	dehydrogenase complex catalyzes the overall conversion of
TSC_c02720	COG1404	Belongs to the peptidase S8 family
TSC_c02740	COG0137	argininosuccinate synthase activity
TSC_c02750	COG0165	Argininosuccinate lyase
TSC_c02760	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TSC_c02760	COG0165	Argininosuccinate lyase
TSC_c02790	COG0505	Belongs to the CarA family
TSC_c02800	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TSC_c02910	COG2244	polysaccharide biosynthetic process
TSC_c02930	COG1216	Glycosyl transferase, family 2
TSC_c02960	COG0438	transferase activity, transferring glycosyl groups
TSC_c02980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TSC_c03000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
TSC_c03060	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TSC_c03070	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TSC_c03080	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TSC_c03090	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TSC_c03120	COG0799	negative regulation of ribosome biogenesis
TSC_c03130	COG4636	protein conserved in cyanobacteria
TSC_c03140	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TSC_c03200	COG0739	heme binding
TSC_c03220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TSC_c03230	COG0825	malonyl-CoA metabolic process
TSC_c03270	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_c03290	COG1278	Cold shock
TSC_c03300	COG0484	heat shock protein binding
TSC_c03320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TSC_c03330	COG1968	undecaprenyl-diphosphatase activity
TSC_c03340	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TSC_c03350	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TSC_c03380	COG1309	transcriptional regulator
TSC_c03440	COG0437	4 iron, 4 sulfur cluster binding
TSC_c03490	COG1252	NADH dehydrogenase
TSC_c03510	COG3706	GGDEF domain
TSC_c03520	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSC_c03550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TSC_c03570	COG1185	polyribonucleotide nucleotidyltransferase activity
TSC_c03580	COG3118	belongs to the thioredoxin family
TSC_c03590	COG0416	fatty acid biosynthetic process
TSC_c03610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSC_c03640	COG0284	orotidine-5'-phosphate decarboxylase activity
TSC_c03650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSC_c03670	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TSC_c03710	COG0822	iron-sulfur transferase activity
TSC_c03720	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TSC_c03740	COG2132	Multicopper oxidase
TSC_c03790	COG2226	methyltransferase
TSC_c03820	COG5002	protein histidine kinase activity
TSC_c03830	COG0745	RESPONSE REGULATOR receiver
TSC_c03860	COG2217	Heavy metal translocating P-type atpase
TSC_c03900	COG0719	Fe-S assembly protein
TSC_c03910	COG0719	Fe-S assembly protein
TSC_c03920	COG0396	ATPase activity
TSC_c03950	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSC_c03960	COG1136	(ABC) transporter
TSC_c03970	COG1136	(ABC) transporter
TSC_c03970	COG0577	efflux transmembrane transporter activity
TSC_c04010	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSC_c04030	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TSC_c04090	COG4948	Mandelate Racemase Muconate Lactonizing
TSC_c04120	COG0354	folic acid binding
TSC_c04130	COG1058	Belongs to the CinA family
TSC_c04130	COG1546	Belongs to the CinA family
TSC_c04140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TSC_c04160	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TSC_c04160	COG1418	mRNA catabolic process
TSC_c04190	COG1077	Cell shape determining protein MreB Mrl
TSC_c04200	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TSC_c04250	COG0235	Class ii aldolase
TSC_c04290	COG1177	transmembrane transport
TSC_c04300	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TSC_c04310	COG1607	acyl-coa hydrolase
TSC_c04320	COG2154	pterin-4-alpha-carbinolamine dehydratase
TSC_c04340	COG0277	FAD linked oxidase domain protein
TSC_c04390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TSC_c04420	COG4555	ABC transporter
TSC_c04430	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
TSC_c04450	COG0667	Aldo Keto reductase
TSC_c04480	COG0517	IMP dehydrogenase activity
TSC_c04500	COG1067	ATP-dependent peptidase activity
TSC_c04510	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TSC_c04530	COG0745	RESPONSE REGULATOR receiver
TSC_c04540	COG2105	PFAM AIG2 family protein
TSC_c04550	COG0297	glycogen (starch) synthase activity
TSC_c04570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TSC_c04580	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TSC_c04610	COG0142	geranyltranstransferase activity
TSC_c04630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TSC_c04700	COG0582	viral genome integration into host DNA
TSC_c04750	COG1121	(ABC) transporter
TSC_c04780	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TSC_c04810	COG0516	GMP reductase activity
TSC_c04810	COG0517	IMP dehydrogenase activity
TSC_c04840	COG2205	protein histidine kinase activity
TSC_c04880	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSC_c04910	COG1324	tolerance protein
TSC_c04920	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TSC_c04930	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TSC_c04940	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TSC_c04950	COG2197	response regulator
TSC_c04980	COG1132	(ABC) transporter
TSC_c04990	COG1132	(ABC) transporter
TSC_c05000	COG0285	dihydrofolate synthase activity
TSC_c05030	COG0601	transmembrane transport
TSC_c05040	COG0747	negative chemotaxis
TSC_c05080	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSC_c05100	COG0174	glutamine synthetase
TSC_c05110	COG0737	Belongs to the 5'-nucleotidase family
TSC_c05130	COG2010	Cytochrome c
TSC_c05150	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TSC_c05160	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TSC_c05170	COG0788	formyltetrahydrofolate deformylase activity
TSC_c05270	COG2814	Major facilitator Superfamily
TSC_c05280	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TSC_c05290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSC_c05300	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TSC_c05340	COG2050	protein possibly involved in aromatic compounds catabolism
TSC_c05350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TSC_c05410	COG0247	lactate metabolic process
TSC_c05420	COG0277	FAD linked oxidase domain protein
TSC_c05430	COG0277	FAD linked oxidase domain protein
TSC_c05450	COG1414	Transcriptional regulator
TSC_c05460	COG0789	Transcriptional regulator
TSC_c05470	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSC_c05480	COG2045	Belongs to the ComB family
TSC_c05490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSC_c05500	COG1136	(ABC) transporter
TSC_c05520	COG1024	Enoyl-CoA hydratase
TSC_c05550	COG0318	PFAM AMP-dependent synthetase and ligase
TSC_c05560	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSC_c05570	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSC_c05600	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TSC_c05640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TSC_c05670	COG1837	Belongs to the UPF0109 family
TSC_c05680	COG0706	membrane insertase activity
TSC_c05690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TSC_c05770	COG0410	ABC transporter
TSC_c05810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TSC_c05820	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TSC_c05830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TSC_c05840	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TSC_c05850	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c05860	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TSC_c05870	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSC_c05880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TSC_c05920	COG1007	ATP synthesis coupled electron transport
TSC_c05930	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_c05940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TSC_c05950	COG0713	ATP synthesis coupled electron transport
TSC_c05960	COG0839	Belongs to the complex I subunit 6 family
TSC_c05970	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_c05980	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TSC_c05990	COG1034	ATP synthesis coupled electron transport
TSC_c06000	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TSC_c06010	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TSC_c06020	COG0649	NAD binding
TSC_c06030	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_c06040	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_c06050	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TSC_c06060	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TSC_c06080	COG4712	double-strand break repair protein
TSC_c06180	COG0131	Imidazoleglycerol-phosphate dehydratase
TSC_c06190	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TSC_c06200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TSC_c06210	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TSC_c06230	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
TSC_c06270	COG0861	Integral membrane protein TerC family
TSC_c06290	COG2151	metal-sulfur cluster biosynthetic enzyme
TSC_c06310	COG1714	RDD family
TSC_c06320	COG0616	signal peptide processing
TSC_c06330	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSC_c06340	COG0372	Belongs to the citrate synthase family
TSC_c06350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TSC_c06370	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TSC_c06380	COG0758	DNA mediated transformation
TSC_c06380	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TSC_c06390	COG3546	catalase activity
TSC_c06400	COG0583	DNA-binding transcription factor activity
TSC_c06420	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSC_c06430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TSC_c06440	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TSC_c06460	COG0717	Belongs to the dCTP deaminase family
TSC_c06480	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
TSC_c06480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSC_c06490	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c06500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TSC_c06550	COG0515	serine threonine protein kinase
TSC_c06550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSC_c06570	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TSC_c06590	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TSC_c06610	COG0704	Plays a role in the regulation of phosphate uptake
TSC_c06620	COG2205	protein histidine kinase activity
TSC_c06630	COG0745	RESPONSE REGULATOR receiver
TSC_c06650	COG0582	viral genome integration into host DNA
TSC_c06720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TSC_c06770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
TSC_c06780	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TSC_c06810	COG1063	alcohol dehydrogenase
TSC_c06840	COG3181	Tripartite tricarboxylate transporter family receptor
TSC_c06850	COG0281	malic enzyme
TSC_c06880	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TSC_c06890	COG0509	glycine decarboxylation via glycine cleavage system
TSC_c06900	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSC_c06910	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TSC_c06950	COG0243	molybdopterin cofactor binding
TSC_c06970	COG2197	response regulator
TSC_c06990	COG0196	riboflavin kinase activity
TSC_c07000	COG0494	nUDIX hydrolase
TSC_c07040	COG2813	Specifically methylates the guanine in position
TSC_c07060	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TSC_c07070	COG0039	L-malate dehydrogenase activity
TSC_c07080	COG0358	DNA primase activity
TSC_c07110	COG1111	helicase
TSC_c07110	COG1205	dead DEAH box helicase
TSC_c07120	COG0456	acetyltransferase
TSC_c07150	COG0009	L-threonylcarbamoyladenylate synthase
TSC_c07190	COG3706	GGDEF domain
TSC_c07200	COG0287	Prephenate dehydrogenase
TSC_c07210	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TSC_c07220	COG2514	catechol 2,3-dioxygenase activity
TSC_c07230	COG2353	YceI-like domain
TSC_c07240	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TSC_c07250	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TSC_c07290	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_c07300	COG0179	Fumarylacetoacetate (FAA) hydrolase
TSC_c07320	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TSC_c07330	COG0151	Belongs to the GarS family
TSC_c07340	COG5002	protein histidine kinase activity
TSC_c07340	COG2176	DNA-directed DNA polymerase activity
TSC_c07360	COG2205	protein histidine kinase activity
TSC_c07410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TSC_c07430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSC_c07440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSC_c07450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TSC_c07490	COG1733	regulation of RNA biosynthetic process
TSC_c07500	COG2894	cell division
TSC_c07510	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TSC_c07520	COG0772	Belongs to the SEDS family
TSC_c07530	COG3842	ATPase activity
TSC_c07540	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSC_c07550	COG1177	transmembrane transport
TSC_c07560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSC_c07570	COG2010	Cytochrome c
TSC_c07580	COG0129	dihydroxy-acid dehydratase activity
TSC_c07590	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c07620	COG0473	3-isopropylmalate dehydrogenase activity
TSC_c07630	COG0066	3-isopropylmalate dehydratase activity
TSC_c07650	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TSC_c07680	COG0180	Tryptophanyl-tRNA synthetase
TSC_c07740	COG0183	Belongs to the thiolase family
TSC_c07760	COG2361	Protein of unknown function DUF86
TSC_c07790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TSC_c07800	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TSC_c07820	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TSC_c07830	COG1254	Belongs to the acylphosphatase family
TSC_c07850	COG1063	alcohol dehydrogenase
TSC_c07860	COG2133	pyrroloquinoline quinone binding
TSC_c07870	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TSC_c07920	COG0420	3'-5' exonuclease activity
TSC_c07930	COG0419	ATPase involved in DNA repair
TSC_c07990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TSC_c08000	COG0612	Peptidase, M16
TSC_c08010	COG0612	Peptidase, M16
TSC_c08020	COG0697	spore germination
TSC_c08030	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSC_c08070	COG4956	integral membrane protein (PIN domain superfamily)
TSC_c08080	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TSC_c08090	COG0542	response to heat
TSC_c08100	COG0423	glycine-tRNA ligase activity
TSC_c08140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TSC_c08160	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TSC_c08220	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TSC_c08270	COG1024	Enoyl-CoA hydratase
TSC_c08280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TSC_c08290	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TSC_c08310	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TSC_c08330	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_c08340	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TSC_c08350	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TSC_c08370	COG0861	Integral membrane protein TerC family
TSC_c08380	COG0492	ferredoxin-NADP+ reductase activity
TSC_c08390	COG0028	Belongs to the TPP enzyme family
TSC_c08400	COG0440	acetolactate synthase activity
TSC_c08410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TSC_c08430	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TSC_c08460	COG4555	ABC transporter
TSC_c08520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_c08540	COG1573	uracil-dna glycosylase
TSC_c08580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TSC_c08610	COG1316	TRANSCRIPTIONal
TSC_c08680	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TSC_c08710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TSC_c08730	COG1269	ATP hydrolysis coupled proton transport
TSC_c08750	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSC_c08760	COG1527	subunit (C
TSC_c08770	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TSC_c08780	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TSC_c08790	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TSC_c08800	COG1394	ATPase activity, coupled to movement of substances
TSC_c08810	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TSC_c08910	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSC_c08930	COG1760	l-serine dehydratase
TSC_c08950	COG0481	GTPase activity
TSC_c08970	COG1960	acyl-CoA dehydrogenase activity
TSC_c08980	COG0183	Belongs to the thiolase family
TSC_c09000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSC_c09010	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c09020	COG0410	ABC transporter
TSC_c09040	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSC_c09070	COG2030	dehydratase
TSC_c09090	COG0596	Alpha beta hydrolase
TSC_c09110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TSC_c09120	COG2909	trisaccharide binding
TSC_c09130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSC_c09130	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TSC_c09150	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TSC_c09170	COG0195	Participates in both transcription termination and antitermination
TSC_c09180	COG0779	Required for maturation of 30S ribosomal subunits
TSC_c09190	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSC_c09190	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TSC_c09210	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSC_c09210	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TSC_c09250	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_c09250	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TSC_c09270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TSC_c09280	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TSC_c09310	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TSC_c09320	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TSC_c09330	COG1702	phosphate starvation-inducible protein PhoH
TSC_c09350	COG4864	UPF0365 protein
TSC_c09370	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TSC_c09400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TSC_c09410	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TSC_c09420	COG0824	Thioesterase
TSC_c09440	COG0557	exoribonuclease II activity
TSC_c09450	COG1355	regulation of microtubule-based process
TSC_c09460	COG0237	dephospho-CoA kinase activity
TSC_c09480	COG4221	oxidoreductase activity
TSC_c09500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TSC_c09550	COG0559	Belongs to the binding-protein-dependent transport system permease family
TSC_c09560	COG0683	leucine binding
TSC_c09570	COG0165	Argininosuccinate lyase
TSC_c09580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
TSC_c09630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TSC_c09640	COG1185	polyribonucleotide nucleotidyltransferase activity
TSC_c09650	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TSC_c09680	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TSC_c09690	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TSC_c09700	COG1100	Small GTP-binding protein
TSC_c09730	COG0010	Belongs to the arginase family
TSC_c09770	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TSC_c09780	COG0511	ligase activity, forming carbon-carbon bonds
TSC_c09790	COG0439	Biotin carboxylase
TSC_c09810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TSC_c09820	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TSC_c09830	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TSC_c09850	COG2181	nitrate reductase activity
TSC_c09850	COG0247	lactate metabolic process
TSC_c09870	COG0861	Integral membrane protein TerC family
TSC_c09880	COG2819	hydrolase of the alpha beta superfamily
TSC_c09900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSC_c09910	COG0438	transferase activity, transferring glycosyl groups
TSC_c10000	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TSC_c10010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TSC_c10030	COG3383	formate dehydrogenase (NAD+) activity
TSC_c10030	COG0243	molybdopterin cofactor binding
TSC_c10040	COG0437	4 iron, 4 sulfur cluster binding
TSC_c10070	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TSC_c10080	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSC_c10150	COG4983	Phage plasmid primase, P4 family domain protein
TSC_c10190	COG1129	ABC transporter
TSC_c10240	COG0494	nUDIX hydrolase
TSC_c10260	COG0138	bifunctional purine biosynthesis protein purh
TSC_c10280	COG2337	Toxic component of a toxin-antitoxin (TA) module
TSC_c10290	COG3239	Fatty acid desaturase
TSC_c10300	COG1490	D-aminoacyl-tRNA deacylase activity
TSC_c10310	COG1307	EDD domain protein, DegV family
TSC_c10320	COG1307	EDD domain protein, DegV family
TSC_c10330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TSC_c10370	COG1136	(ABC) transporter
TSC_c10370	COG0577	efflux transmembrane transporter activity
TSC_c10380	COG1136	(ABC) transporter
TSC_c10420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TSC_c10440	COG1012	belongs to the aldehyde dehydrogenase family
TSC_c10450	COG2368	4-hydroxyphenylacetate
TSC_c10460	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TSC_c10500	COG0411	ABC transporter
TSC_c10530	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TSC_c10560	COG1492	cobalamin metabolic process
TSC_c10570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TSC_c10590	COG0574	Belongs to the PEP-utilizing enzyme family
TSC_c10590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSC_c10600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TSC_c10640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TSC_c10650	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TSC_c10680	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TSC_c10700	COG0601	transmembrane transport
TSC_c10720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSC_c10740	COG2226	methyltransferase
TSC_c10760	COG0601	transmembrane transport
TSC_c10780	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TSC_c10790	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
TSC_c10810	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
TSC_c10820	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
TSC_c10830	COG1472	Belongs to the glycosyl hydrolase 3 family
TSC_c10850	COG1175	transmembrane transport
TSC_c10860	COG0395	ABC-type sugar transport system, permease component
TSC_c10870	COG0019	diaminopimelate decarboxylase activity
TSC_c10890	COG2205	protein histidine kinase activity
TSC_c10940	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
TSC_c10970	COG0589	response to stress
TSC_c11000	COG1993	acr, cog1993
TSC_c11030	COG1193	negative regulation of DNA recombination
TSC_c11070	COG0642	Histidine kinase
TSC_c11090	COG2010	Cytochrome c
TSC_c11100	COG1914	H( )-stimulated, divalent metal cation uptake system
TSC_c11140	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSC_c11150	COG2323	membrane
TSC_c11180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSC_c11200	COG3258	Cytochrome c
TSC_c11210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TSC_c11220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TSC_c11230	COG0363	glucosamine-6-phosphate deaminase activity
TSC_c11250	COG0723	plastoquinol--plastocyanin reductase activity
TSC_c11260	COG0730	response to heat
TSC_c11350	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TSC_c11350	COG1240	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
TSC_c11400	COG1802	Transcriptional regulator
TSC_c11420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSC_c11470	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
TSC_c11480	COG4638	Rieske (2fe-2S)
TSC_c11490	COG1129	ABC transporter
TSC_c11580	COG1942	4-Oxalocrotonate Tautomerase
TSC_c11630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TSC_c11670	COG0588	phosphoglycerate mutase activity
TSC_c11690	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TSC_c11700	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TSC_c11720	COG1797	cobyrinic acid a,c-diamide synthase activity
TSC_c11730	COG2046	Belongs to the sulfate adenylyltransferase family
TSC_c11740	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSC_c11740	COG1648	precorrin-2 dehydrogenase activity
TSC_c11750	COG0730	response to heat
TSC_c11760	COG0175	sulfate reduction
TSC_c11770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TSC_c11770	COG1648	precorrin-2 dehydrogenase activity
TSC_c11780	COG1587	Uroporphyrinogen-III synthase
TSC_c11790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TSC_c11800	COG0352	thiamine-phosphate diphosphorylase activity
TSC_c11810	COG2104	thiamine diphosphate biosynthetic process
TSC_c11820	COG2022	thiamine diphosphate biosynthetic process
TSC_c11830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TSC_c11830	COG2022	thiamine diphosphate biosynthetic process
TSC_c11840	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TSC_c11860	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c11870	COG0318	PFAM AMP-dependent synthetase and ligase
TSC_c11890	COG1012	belongs to the aldehyde dehydrogenase family
TSC_c11890	COG2030	dehydratase
TSC_c11900	COG1960	acyl-CoA dehydrogenase activity
TSC_c11910	COG1309	transcriptional regulator
TSC_c11920	COG1980	fructose-bisphosphate aldolase activity
TSC_c11950	COG3300	MHYT domain
TSC_c11950	COG5001	Diguanylate cyclase
TSC_c11980	COG2186	Transcriptional regulator
TSC_c11990	COG0747	negative chemotaxis
TSC_c12040	COG0395	ABC-type sugar transport system, permease component
TSC_c12050	COG1175	transmembrane transport
TSC_c12070	COG1609	Transcriptional regulator
TSC_c12090	COG1607	acyl-coa hydrolase
TSC_c12120	COG4974	Belongs to the 'phage' integrase family
TSC_c12150	COG3396	Phenylacetate-CoA oxygenase
TSC_c12170	COG3396	Phenylacetate-CoA oxygenase
TSC_c12190	COG2030	dehydratase
TSC_c12190	COG1012	belongs to the aldehyde dehydrogenase family
TSC_c12200	COG1733	regulation of RNA biosynthetic process
TSC_c12210	COG2193	ferroxidase activity
TSC_c12220	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TSC_c12230	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TSC_c12320	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TSC_c12380	COG3328	transposase activity
TSC_c12410	COG2361	Protein of unknown function DUF86
TSC_c12440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TSC_c12480	COG1857	crispr-associated protein
TSC_c12650	COG1012	belongs to the aldehyde dehydrogenase family
TSC_c12700	COG1331	Highly conserved protein containing a thioredoxin domain
TSC_c12710	COG0183	Belongs to the thiolase family
TSC_c12720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TSC_c12730	COG0477	Major facilitator Superfamily
TSC_c12750	COG1960	acyl-CoA dehydrogenase activity
TSC_c12760	COG2414	aldehyde ferredoxin oxidoreductase
TSC_c12780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TSC_c12780	COG3153	acetyltransferase
TSC_c12790	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSC_c12800	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSC_c12810	COG1177	transmembrane transport
TSC_c12820	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSC_c12840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TSC_c12850	COG1012	belongs to the aldehyde dehydrogenase family
TSC_c12860	COG1177	transmembrane transport
TSC_c12870	COG1176	ABC-type spermidine putrescine transport system, permease component I
TSC_c12880	COG3842	ATPase activity
TSC_c12890	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TSC_c12900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TSC_c12930	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TSC_c12940	COG0803	Belongs to the bacterial solute-binding protein 9 family
TSC_c12950	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TSC_c12960	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TSC_c12980	COG3383	formate dehydrogenase (NAD+) activity
TSC_c12990	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSC_c13020	COG1960	acyl-CoA dehydrogenase activity
TSC_c13030	COG2086	electron transfer activity
TSC_c13040	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TSC_c13060	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSC_c13070	COG1573	uracil-dna glycosylase
TSC_c13080	COG1796	DNA polymerase
TSC_c13080	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TSC_c13110	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TSC_c13110	COG1013	pyruvate-flavodoxin oxidoreductase activity
TSC_c13110	COG0674	pyruvate-flavodoxin oxidoreductase activity
TSC_c13110	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_c13140	COG2873	o-acetylhomoserine
TSC_c13160	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TSC_c13170	COG0215	cysteine-tRNA ligase activity
TSC_c13180	COG1960	acyl-CoA dehydrogenase activity
TSC_c13190	COG0183	Belongs to the thiolase family
TSC_c13200	COG1250	3-hydroxyacyl-CoA dehydrogenase
TSC_c13200	COG1024	Enoyl-CoA hydratase
TSC_c13230	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TSC_c13250	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TSC_c13260	COG0438	transferase activity, transferring glycosyl groups
TSC_c13270	COG0438	transferase activity, transferring glycosyl groups
TSC_c13310	COG1811	Na channel or pump
TSC_c13320	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TSC_c13330	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TSC_c13340	COG4948	Mandelate Racemase Muconate Lactonizing
TSC_c13360	COG0402	S-adenosylhomocysteine deaminase activity
TSC_c13400	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TSC_c13410	COG0742	ribosomal rna small subunit methyltransferase
TSC_c13440	COG2873	o-acetylhomoserine
TSC_c13450	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TSC_c13460	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TSC_c13470	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TSC_c13600	COG0149	triose-phosphate isomerase activity
TSC_c13610	COG0126	phosphoglycerate kinase activity
TSC_c13630	COG1268	BioY protein
TSC_c13650	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TSC_c13680	COG1196	nuclear chromosome segregation
TSC_c13710	COG2738	Putative neutral zinc metallopeptidase
TSC_c13790	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TSC_c13820	COG2897	thiosulfate sulfurtransferase activity
TSC_c13830	COG1760	l-serine dehydratase
TSC_c13840	COG2197	response regulator
TSC_c13850	COG0335	large ribosomal subunit rRNA binding
TSC_c13860	COG0336	Belongs to the RNA methyltransferase TrmD family
TSC_c13870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TSC_c13890	COG0228	four-way junction DNA binding
TSC_c13910	COG2239	Acts as a magnesium transporter
TSC_c13930	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TSC_c13950	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TSC_c13960	COG1692	metallophosphoesterase
TSC_c13990	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TSC_c14010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TSC_c14020	COG1410	methionine synthase
TSC_c14020	COG0646	methionine synthase
TSC_c14030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TSC_c14040	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TSC_c14050	COG0740	serine-type endopeptidase activity
TSC_c14060	COG0544	peptidyl-prolyl cis-trans isomerase activity
TSC_c14100	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TSC_c14110	COG3870	Protein conserved in bacteria
TSC_c14120	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TSC_c14140	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TSC_c14180	COG4475	Protein of unknown function (DUF436)
TSC_c14220	COG0651	ATP synthesis coupled electron transport
TSC_c14250	COG0651	ATP synthesis coupled electron transport
TSC_c14280	COG1970	mechanosensitive ion channel activity
TSC_c14290	COG3842	ATPase activity
TSC_c14300	COG0572	uridine kinase
TSC_c14340	COG2176	DNA-directed DNA polymerase activity
TSC_c14350	COG0154	amidase activity
TSC_c14360	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TSC_c14380	COG1435	thymidine kinase activity
TSC_c14400	COG0254	rRNA binding
TSC_c14420	COG2001	Belongs to the MraZ family
TSC_c14430	COG0275	rRNA processing
TSC_c14450	COG0768	penicillin binding
TSC_c14460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TSC_c14480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TSC_c14490	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TSC_c14500	COG0772	Belongs to the SEDS family
TSC_c14510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TSC_c14520	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TSC_c14530	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TSC_c14570	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TSC_c14580	COG2197	response regulator
TSC_c14660	COG2391	methyltransferase activity
TSC_c14680	COG0243	molybdopterin cofactor binding
TSC_c14740	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c14770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TSC_c14870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TSC_c14880	COG2264	protein methyltransferase activity
TSC_c14900	COG0489	protein tyrosine kinase activity
TSC_c14920	COG0525	valine-tRNA ligase activity
TSC_c14940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TSC_c14960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TSC_c14970	COG0134	indole-3-glycerol-phosphate synthase activity
TSC_c14980	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSC_c15000	COG1126	abc transporter atp-binding protein
TSC_c15030	COG0765	amino acid transport
TSC_c15040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TSC_c15060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TSC_c15070	COG0569	domain protein
TSC_c15080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSC_c15100	COG2313	pseudouridylate synthase activity
TSC_c15110	COG2313	pseudouridylate synthase activity
TSC_c15140	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TSC_c15150	COG4585	Histidine kinase
TSC_c15200	COG0012	GTP binding
TSC_c15210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TSC_c15230	COG0424	maF-like protein
TSC_c15260	COG0768	penicillin binding
TSC_c15280	COG2322	membrane
TSC_c15320	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TSC_c15330	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TSC_c15350	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TSC_c15380	COG3842	ATPase activity
TSC_c15400	COG0124	histidyl-tRNA synthetase
TSC_c15410	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TSC_c15420	COG0384	phenazine biosynthesis protein PhzF
TSC_c15430	COG0561	phosphatase activity
TSC_c15460	COG0745	RESPONSE REGULATOR receiver
TSC_c15480	COG0017	Asparaginyl-tRNA synthetase
TSC_c15490	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TSC_c15510	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TSC_c15520	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TSC_c15540	COG0640	Transcriptional regulator
TSC_c15550	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TSC_c15560	COG0739	heme binding
TSC_c15570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TSC_c15580	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TSC_c15590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TSC_c15610	COG0006	proline dipeptidase activity
TSC_c15620	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TSC_c15630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TSC_c15640	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TSC_c15670	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TSC_c15690	COG1994	Peptidase M50
TSC_c15710	COG0617	tRNA 3'-terminal CCA addition
TSC_c15830	COG0542	response to heat
TSC_c15880	COG2199	diguanylate cyclase activity
TSC_c15880	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSC_c16120	COG4712	double-strand break repair protein
TSC_c16170	COG0210	DNA helicase
TSC_c16190	COG3864	Putative metallopeptidase domain
TSC_c16200	COG0714	Associated with various cellular activities
TSC_c16570	COG1994	Peptidase M50
TSC_c16650	COG1072	(Pantothenic acid kinase))
TSC_c16710	COG1063	alcohol dehydrogenase
TSC_c16720	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TSC_c16730	COG1012	belongs to the aldehyde dehydrogenase family
TSC_c16800	COG0395	ABC-type sugar transport system, permease component
TSC_c16830	COG0463	Glycosyl transferase, family 2
TSC_c16880	COG1598	PFAM Uncharacterised protein family UPF0150
TSC_c16930	COG0582	viral genome integration into host DNA
TSC_c16950	COG0052	Belongs to the universal ribosomal protein uS2 family
TSC_c16960	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TSC_c16970	COG0528	UMP kinase activity
TSC_c16980	COG0233	cytoplasmic translational termination
TSC_c16990	COG4589	Belongs to the CDS family
TSC_c17000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TSC_c17010	COG0750	zinc metalloprotease
TSC_c17040	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TSC_c17050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSC_c17060	COG2359	stage V sporulation protein S
TSC_c17080	COG2137	regulation of response to DNA damage stimulus
TSC_c17120	COG2766	serine protein kinase
TSC_c17130	COG2718	Belongs to the UPF0229 family
TSC_c17140	COG2719	SpoVR family
TSC_c17150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSC_c17160	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TSC_c17190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TSC_c17220	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TSC_c17230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TSC_c17240	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TSC_c17260	COG3706	GGDEF domain
TSC_c17270	COG3335	DDE superfamily endonuclease
TSC_c17290	COG0730	response to heat
TSC_c17310	COG2323	membrane
TSC_c17340	COG2205	protein histidine kinase activity
TSC_c17350	COG0745	RESPONSE REGULATOR receiver
TSC_c17360	COG0671	phosphoesterase, PA-phosphatase related
TSC_c17390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TSC_c17400	COG2151	metal-sulfur cluster biosynthetic enzyme
TSC_c17480	COG2181	nitrate reductase activity
TSC_c17510	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TSC_c17540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TSC_c17550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_c17570	COG0535	radical SAM domain protein
TSC_c17580	COG2010	Cytochrome c
TSC_c17600	COG3256	nitric oxide reductase
TSC_c17610	COG2010	Cytochrome c
TSC_c17630	COG2832	Protein of unknown function (DUF454)
TSC_c17720	COG1252	NADH dehydrogenase
TSC_c17730	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TSC_c17750	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TSC_c17760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSC_c17770	COG3191	aminopeptidase activity
TSC_c17790	COG1063	alcohol dehydrogenase
TSC_c17800	COG0714	Associated with various cellular activities
TSC_c17840	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TSC_c17850	COG2884	Cell division ATP-binding protein ftsE
TSC_c17860	COG0793	Belongs to the peptidase S41A family
TSC_c17870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_c17870	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_c17880	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TSC_c17890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TSC_c17910	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TSC_c17920	COG0159	tryptophan synthase activity
TSC_c17930	COG0133	tryptophan synthase activity
TSC_c17940	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TSC_c17970	COG1744	ABC transporter substrate-binding protein PnrA-like
TSC_c18030	COG1605	Chorismate mutase
TSC_c18030	COG0077	Prephenate dehydratase
TSC_c18040	COG0745	RESPONSE REGULATOR receiver
TSC_c18050	COG0517	IMP dehydrogenase activity
TSC_c18080	COG1674	ftsk spoiiie
TSC_c18100	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TSC_c18110	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TSC_c18120	COG4651	solute:proton antiporter activity
TSC_c18120	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TSC_c18130	COG0217	transcriptional regulatory protein
TSC_c18140	COG0653	protein targeting
TSC_c18150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TSC_c18210	COG1960	acyl-CoA dehydrogenase activity
TSC_c18230	COG0312	modulator of DNA gyrase
TSC_c18240	COG0312	modulator of DNA gyrase
TSC_c18280	COG0730	response to heat
TSC_c18340	COG0167	dihydroorotate dehydrogenase activity
TSC_c18360	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TSC_c18440	COG0746	molybdenum cofactor guanylyltransferase activity
TSC_c18470	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSC_c18520	COG0538	isocitrate dehydrogenase activity
TSC_c18530	COG0557	exoribonuclease II activity
TSC_c18590	COG0585	pseudouridine synthase activity
TSC_c18630	COG2050	protein possibly involved in aromatic compounds catabolism
TSC_c18650	COG0322	excinuclease ABC activity
TSC_c18660	COG0018	arginyl-trna synthetase
TSC_c18670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TSC_c18680	COG1428	Deoxynucleoside kinase
TSC_c18690	COG1428	Deoxynucleoside kinase
TSC_c18700	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TSC_c18710	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TSC_c18720	COG0107	imidazoleglycerol-phosphate synthase activity
TSC_c18730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TSC_c18730	COG0140	phosphoribosyl-ATP diphosphatase activity
TSC_c18750	COG1494	fructose-1,6-bisphosphatase
TSC_c18800	COG0395	ABC-type sugar transport system, permease component
TSC_c18810	COG1175	transmembrane transport
TSC_c18910	COG0084	hydrolase, TatD family'
TSC_c18920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TSC_c18940	COG0017	Asparaginyl-tRNA synthetase
TSC_c18960	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TSC_c18990	COG2009	succinate dehydrogenase
TSC_c19010	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TSC_c19070	COG0318	PFAM AMP-dependent synthetase and ligase
TSC_c19080	COG1104	cysteine desulfurase activity
TSC_c19090	COG1959	2 iron, 2 sulfur cluster binding
TSC_c19100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TSC_c19110	COG1121	(ABC) transporter
TSC_c19130	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TSC_c19140	COG2255	four-way junction helicase activity
TSC_c19180	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TSC_c19200	COG1085	galactose-1-phosphate uridylyltransferase
TSC_c19210	COG3345	alpha-galactosidase
TSC_c19220	COG2211	Major facilitator Superfamily
TSC_c19260	COG2211	Major facilitator Superfamily
TSC_c19280	COG1181	Belongs to the D-alanine--D-alanine ligase family
TSC_c19290	COG0193	aminoacyl-tRNA hydrolase activity
TSC_c19300	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TSC_c19310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSC_c19320	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TSC_c19330	COG1854	S-ribosylhomocysteine lyase activity
TSC_c19340	COG0519	Catalyzes the synthesis of GMP from XMP
TSC_c19340	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TSC_c19350	COG4636	protein conserved in cyanobacteria
TSC_c19360	COG4274	PFAM GYD family protein
TSC_c19390	COG0328	RNA-DNA hybrid ribonuclease activity
TSC_c19400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TSC_c19470	COG0590	tRNA wobble adenosine to inosine editing
TSC_c19470	COG0037	tRNA processing
TSC_c19500	COG0366	Alpha amylase catalytic
TSC_c19530	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TSC_c19550	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TSC_c19560	COG0460	homoserine dehydrogenase
TSC_c19570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TSC_c19640	COG0037	tRNA processing
TSC_c19650	COG2104	thiamine diphosphate biosynthetic process
TSC_c19660	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSC_c19670	COG0517	IMP dehydrogenase activity
TSC_c19690	COG0444	Belongs to the ABC transporter superfamily
TSC_c19700	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_c19710	COG0601	transmembrane transport
TSC_c19720	COG0747	negative chemotaxis
TSC_c19730	COG0604	alcohol dehydrogenase
TSC_c19740	COG0492	ferredoxin-NADP+ reductase activity
TSC_c19820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_c19830	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSC_c19840	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TSC_c19880	COG2070	2-Nitropropane dioxygenase
TSC_c19920	COG0745	RESPONSE REGULATOR receiver
TSC_c19930	COG5002	protein histidine kinase activity
TSC_c19970	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TSC_c19990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TSC_c20030	COG0513	Belongs to the DEAD box helicase family
TSC_c20040	COG0303	'Molybdopterin
TSC_c20080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TSC_c20090	COG0442	prolyl-tRNA aminoacylation
TSC_c20110	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TSC_c20120	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TSC_c20150	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c20160	COG2816	NAD+ diphosphatase activity
TSC_c20180	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TSC_c20190	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TSC_c20210	COG1482	cell wall glycoprotein biosynthetic process
TSC_c20230	COG1515	deoxyribonuclease V activity
TSC_c20250	COG0776	regulation of translation
TSC_c20260	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TSC_c20270	COG0443	Heat shock 70 kDa protein
TSC_c20280	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TSC_c20290	COG0484	heat shock protein binding
TSC_c20300	COG0789	Transcriptional regulator
TSC_c20310	COG0542	response to heat
TSC_c20390	COG0490	domain, Protein
TSC_c20400	COG0475	glutathione-regulated potassium exporter activity
TSC_c20440	COG0475	glutathione-regulated potassium exporter activity
TSC_c20490	COG0067	glutamate synthase
TSC_c20490	COG0070	glutamate synthase
TSC_c20490	COG0069	glutamate synthase activity
TSC_c20500	COG0247	lactate metabolic process
TSC_c20510	COG1139	Iron-sulfur cluster binding protein
TSC_c20520	COG1139	Iron-sulfur cluster binding protein
TSC_c20530	COG0681	Belongs to the peptidase S26 family
TSC_c20540	COG1752	Esterase of the alpha-beta hydrolase superfamily
TSC_c20550	COG2815	serine threonine protein kinase
TSC_c20550	COG0515	serine threonine protein kinase
TSC_c20590	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TSC_c20630	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TSC_c20630	COG2199	diguanylate cyclase activity
TSC_c20650	COG0473	3-isopropylmalate dehydrogenase activity
TSC_c20700	COG1450	Type ii and iii secretion system protein
TSC_c20710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TSC_c20720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TSC_c20730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TSC_c20750	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TSC_c20750	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TSC_c20770	COG0736	holo-[acyl-carrier-protein] synthase activity
TSC_c20800	COG1160	GTP binding
TSC_c20830	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TSC_c20840	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TSC_c20840	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TSC_c20850	COG0083	homoserine kinase activity
TSC_c20870	COG0268	Binds directly to 16S ribosomal RNA
TSC_c20890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TSC_c20900	COG0723	plastoquinol--plastocyanin reductase activity
TSC_c20920	COG3088	subunit of a heme lyase
TSC_c20920	COG4235	cytochrome complex assembly
TSC_c20930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TSC_c20940	COG1138	Cytochrome C-type biogenesis protein
TSC_c20950	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TSC_c20960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TSC_c20980	COG4133	protoheme IX ABC transporter activity
TSC_c20990	COG0785	Cytochrome C biogenesis protein
TSC_c21010	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TSC_c21020	COG0446	pyridine nucleotide-disulphide oxidoreductase
TSC_c21050	COG3258	Cytochrome c
TSC_c21060	COG2010	Cytochrome c
TSC_c21070	COG0737	Belongs to the 5'-nucleotidase family
TSC_c21080	COG2010	Cytochrome c
TSC_c21090	COG3258	Cytochrome c
TSC_c21130	COG2010	Cytochrome c
TSC_c21140	COG3842	ATPase activity
TSC_c21180	COG0504	CTP synthase activity
TSC_c21190	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TSC_c21200	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TSC_c21250	COG2205	protein histidine kinase activity
TSC_c21270	COG2815	serine threonine protein kinase
TSC_c21270	COG0515	serine threonine protein kinase
TSC_c21280	COG0631	protein serine/threonine phosphatase activity
TSC_c21310	COG0113	porphobilinogen synthase activity
TSC_c21320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TSC_c21330	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TSC_c21380	COG0823	Involved in the tonB-independent uptake of proteins
TSC_c21380	COG1506	peptidase
TSC_c21380	COG4946	Tricorn protease homolog
TSC_c21390	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TSC_c21400	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TSC_c21450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TSC_c21460	COG1011	Hydrolase
TSC_c21480	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TSC_c21510	COG0537	adenosine 5'-monophosphoramidase activity
TSC_c21520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TSC_c21540	COG0135	phosphoribosylanthranilate isomerase activity
TSC_c21550	COG0483	inositol monophosphate 1-phosphatase activity
TSC_c21570	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TSC_c21580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSC_c21590	COG0714	Associated with various cellular activities
TSC_c21600	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TSC_c21600	COG0574	Belongs to the PEP-utilizing enzyme family
TSC_c21610	COG1272	protein, Hemolysin III
TSC_c21630	COG3850	Histidine kinase
TSC_c21630	COG5002	protein histidine kinase activity
TSC_c21700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TSC_c21730	COG0546	phosphoglycolate phosphatase activity
TSC_c21760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TSC_c21790	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TSC_c21810	COG0047	phosphoribosylformylglycinamidine synthase activity
TSC_c21830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TSC_c21840	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TSC_c21860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TSC_c21870	COG0497	DNA recombination
TSC_c21890	COG2095	MarC family integral membrane protein
TSC_c21900	COG1438	arginine binding
TSC_c21910	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TSC_c21930	COG0194	GDP metabolic process
TSC_c21950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TSC_c21960	COG2385	sporulation resulting in formation of a cellular spore
TSC_c21970	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TSC_c21990	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TSC_c22050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSC_c22060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TSC_c22070	COG0142	geranyltranstransferase activity
TSC_c22160	COG0203	ribosomal protein L17
TSC_c22180	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TSC_c22190	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TSC_c22200	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TSC_c22210	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TSC_c22230	COG0563	adenylate kinase activity
TSC_c22240	COG0201	protein transport
TSC_c22250	COG0200	Binds to the 23S rRNA
TSC_c22260	COG1841	ribosomal large subunit assembly
TSC_c22270	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TSC_c22280	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TSC_c22320	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TSC_c22360	COG0255	Belongs to the universal ribosomal protein uL29 family
TSC_c22370	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TSC_c22380	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TSC_c22390	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TSC_c22400	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TSC_c22410	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TSC_c22420	COG0089	rRNA binding
TSC_c22430	COG0088	Forms part of the polypeptide exit tunnel
TSC_c22440	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TSC_c22450	COG0051	transcription antitermination factor activity, RNA binding
TSC_c22470	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TSC_c22480	COG0049	tRNA binding
TSC_c22490	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TSC_c22540	COG1461	Dihydroxyacetone kinase
TSC_c22560	COG0686	Belongs to the AlaDH PNT family
TSC_c22570	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TSC_c22580	COG1024	Enoyl-CoA hydratase
TSC_c22590	COG1187	pseudouridine synthase activity
TSC_c22620	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TSC_c22630	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TSC_c22640	COG0512	Glutamine amidotransferase of anthranilate synthase
TSC_c22650	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TSC_c22660	COG1012	belongs to the aldehyde dehydrogenase family
TSC_c22670	COG0506	proline dehydrogenase activity
TSC_c22680	COG1802	Transcriptional regulator
TSC_c22710	COG0156	8-amino-7-oxononanoate synthase activity
TSC_c22740	COG0187	DNA topoisomerase II activity
TSC_c22750	COG1643	Atp-dependent helicase
TSC_c22770	COG1063	alcohol dehydrogenase
TSC_c22870	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TSC_c22870	COG1605	Chorismate mutase
TSC_c22880	COG0805	protein transport
TSC_c22890	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TSC_c22900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TSC_c22910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TSC_c22930	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TSC_c22940	COG0792	nuclease activity
TSC_c22960	COG0492	ferredoxin-NADP+ reductase activity
TSC_c22970	COG1028	Short-chain dehydrogenase reductase Sdr
TSC_c22990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TSC_c23010	COG1187	pseudouridine synthase activity
TSC_c23020	COG2720	vancomycin resistance protein
TSC_c23030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TSC_c23040	COG0427	acetyl-CoA hydrolase
TSC_c23050	COG0686	Belongs to the AlaDH PNT family
TSC_c23080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TSC_c23090	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TSC_c23100	COG0071	Belongs to the small heat shock protein (HSP20) family
TSC_c23120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TSC_c23140	COG1764	response to oxidative stress
TSC_c23160	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
TSC_c23190	COG3842	ATPase activity
TSC_c23200	COG0101	tRNA pseudouridine synthase activity
TSC_c23210	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TSC_c23220	COG0601	transmembrane transport
TSC_c23230	COG0747	negative chemotaxis
TSC_c23240	COG0316	Belongs to the HesB IscA family
TSC_c23260	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TSC_c23290	COG1166	arginine decarboxylase activity
TSC_c23300	COG0745	RESPONSE REGULATOR receiver
TSC_c23300	COG3706	GGDEF domain
TSC_c23310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TSC_c23320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TSC_c23340	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TSC_c23380	COG1175	transmembrane transport
TSC_c23390	COG3833	ABC-type maltose transport systems, permease component
TSC_c23400	COG0366	Alpha amylase catalytic
TSC_c23420	COG1193	negative regulation of DNA recombination
TSC_c23430	COG1193	negative regulation of DNA recombination
TSC_c23470	COG2226	methyltransferase
TSC_c23510	COG1774	PSP1 C-terminal conserved region
TSC_c23520	COG0470	DNA polymerase III
TSC_c23590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TSC_c23620	COG1653	transport
TSC_c23660	COG0723	plastoquinol--plastocyanin reductase activity
TSC_c23670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TSC_c23680	COG0539	negative regulation of cytoplasmic translation
TSC_c23740	COG1115	amino acid carrier protein
TSC_c23830	COG1355	regulation of microtubule-based process
TSC_c23890	COG0589	response to stress
TSC_c23900	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TSC_c23910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TSC_c23930	COG1940	carbohydrate kinase activity
TSC_c24010	COG0302	gtp cyclohydrolase
TSC_c24110	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TSC_c24140	COG0395	ABC-type sugar transport system, permease component
TSC_c24150	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TSC_c24160	COG1131	(ABC) transporter
TSC_c24200	COG0556	nucleotide-excision repair
TSC_c24230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TSC_c24320	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TSC_c24330	COG0242	peptide deformylase activity
TSC_c24350	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TSC_c24360	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TSC_c24440	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TSC_c24450	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TSC_c24460	COG0343	queuine tRNA-ribosyltransferase activity
TSC_c24470	COG0628	permease
TSC_c24490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TSC_c24500	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
TSC_c24540	COG1597	lipid kinase activity
TSC_c24570	COG0123	including yeast histone deacetylase and acetoin utilization protein
TSC_c24580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TSC_c24600	COG0004	ammonium transporteR
TSC_c24610	COG0347	Belongs to the P(II) protein family
TSC_c24630	COG0314	molybdopterin synthase activity
TSC_c24660	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TSC_c24670	COG1960	acyl-CoA dehydrogenase activity
TSC_c24690	COG0495	leucyl-tRNA aminoacylation
TSC_c24710	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TSC_c24720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TSC_c24750	COG2096	Adenosyltransferase
TSC_c24770	COG4555	ABC transporter
TSC_c24780	COG1668	transmembrane transport
TSC_c24830	COG1660	Displays ATPase and GTPase activities
TSC_c24840	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TSC_c24870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TSC_c24880	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TSC_c24910	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TSC_c24920	COG0072	phenylalanine-tRNA ligase activity
TSC_c24920	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TSC_c24940	COG0205	6-phosphofructokinase activity
TSC_c24950	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TSC_c24970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TSC_c24980	COG0584	glycerophosphoryl diester phosphodiesterase
TSC_c25030	COG1475	DNA binding
TSC_c25040	COG1192	Involved in chromosome partitioning
TSC_c25050	COG0357	Ribosomal RNA small subunit methyltransferase G
TSC_c25060	COG0445	tRNA wobble uridine modification
TSC_p800090	COG1902	pentaerythritol trinitrate reductase activity
TSC_p800120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA