locus-tag	class	description
MI302_00005	COG4974	Belongs to the 'phage' integrase family
MI302_00030	COG1192	Involved in chromosome partitioning
MI302_00260	COG3854	ATPases associated with a variety of cellular activities
MI302_00265	COG0497	DNA recombination
MI302_00315	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MI302_00380	COG4712	double-strand break repair protein
MI302_00460	COG1404	Belongs to the peptidase S8 family
MI302_00465	COG1475	DNA binding
MI302_00470	COG1192	Involved in chromosome partitioning
MI302_00500	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MI302_00505	COG0445	tRNA wobble uridine modification
MI302_00510	COG0357	Ribosomal RNA small subunit methyltransferase G
MI302_00515	COG1192	Involved in chromosome partitioning
MI302_00520	COG1475	DNA binding
MI302_00545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
MI302_00555	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MI302_00560	COG0205	6-phosphofructokinase activity
MI302_00570	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MI302_00570	COG0072	phenylalanine-tRNA ligase activity
MI302_00590	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MI302_00595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MI302_00610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MI302_00615	COG1660	Displays ATPase and GTPase activities
MI302_00640	COG1668	transmembrane transport
MI302_00645	COG4555	ABC transporter
MI302_00655	COG2096	Adenosyltransferase
MI302_00670	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MI302_00675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MI302_00685	COG0495	leucyl-tRNA aminoacylation
MI302_00695	COG1960	acyl-CoA dehydrogenase activity
MI302_00700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MI302_00715	COG0314	molybdopterin synthase activity
MI302_00720	COG1420	regulation of RNA biosynthetic process
MI302_00725	COG0347	Belongs to the P(II) protein family
MI302_00730	COG0004	ammonium transporteR
MI302_00740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MI302_00750	COG0123	including yeast histone deacetylase and acetoin utilization protein
MI302_00765	COG1597	lipid kinase activity
MI302_00775	COG0436	Aminotransferase
MI302_00785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MI302_00790	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MI302_00800	COG0628	permease
MI302_00805	COG0343	queuine tRNA-ribosyltransferase activity
MI302_00810	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MI302_00815	COG0346	lactoylglutathione lyase activity
MI302_00820	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MI302_00855	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MI302_00860	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MI302_00915	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
MI302_00915	COG2199	diguanylate cyclase activity
MI302_00920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MI302_00935	COG0497	DNA recombination
MI302_00940	COG0556	nucleotide-excision repair
MI302_00960	COG1131	(ABC) transporter
MI302_00975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MI302_00985	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
MI302_00990	COG0395	ABC-type sugar transport system, permease component
MI302_00995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MI302_01020	COG1217	gtp-binding protein TYPA
MI302_01040	COG0302	gtp cyclohydrolase
MI302_01095	COG1940	carbohydrate kinase activity
MI302_01105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MI302_01110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MI302_01115	COG0589	response to stress
MI302_01130	COG1011	Hydrolase
MI302_01170	COG1489	DNA binding
MI302_01190	COG1115	amino acid carrier protein
MI302_01210	COG0539	negative regulation of cytoplasmic translation
MI302_01215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MI302_01220	COG0723	plastoquinol--plastocyanin reductase activity
MI302_01250	COG1653	transport
MI302_01265	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MI302_01285	COG1404	Belongs to the peptidase S8 family
MI302_01290	COG0497	DNA recombination
MI302_01325	COG0470	DNA polymerase III
MI302_01330	COG1774	PSP1 C-terminal conserved region
MI302_01340	COG1079	Belongs to the binding-protein-dependent transport system permease family
MI302_01345	COG4603	Belongs to the binding-protein-dependent transport system permease family
MI302_01350	COG2226	methyltransferase
MI302_01370	COG1193	negative regulation of DNA recombination
MI302_01380	COG0366	Alpha amylase catalytic
MI302_01390	COG1175	transmembrane transport
MI302_01405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MI302_01410	COG1611	Belongs to the LOG family
MI302_01415	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MI302_01420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MI302_01430	COG1166	arginine decarboxylase activity
MI302_01445	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MI302_01455	COG0316	Belongs to the HesB IscA family
MI302_01465	COG0601	transmembrane transport
MI302_01470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MI302_01475	COG0101	tRNA pseudouridine synthase activity
MI302_01480	COG3842	ATPase activity
MI302_01495	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MI302_01505	COG1764	response to oxidative stress
MI302_01515	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MI302_01525	COG0071	Belongs to the small heat shock protein (HSP20) family
MI302_01530	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MI302_01535	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MI302_01550	COG0686	Belongs to the AlaDH PNT family
MI302_01555	COG0427	acetyl-CoA hydrolase
MI302_01560	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MI302_01570	COG2720	vancomycin resistance protein
MI302_01590	COG1187	pseudouridine synthase activity
MI302_01605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MI302_01610	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_01615	COG0492	ferredoxin-NADP+ reductase activity
MI302_01630	COG0792	nuclease activity
MI302_01635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MI302_01650	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MI302_01655	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MI302_01660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MI302_01665	COG0805	protein transport
MI302_01670	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MI302_01670	COG1605	Chorismate mutase
MI302_01715	COG0187	DNA topoisomerase II activity
MI302_01730	COG0156	8-amino-7-oxononanoate synthase activity
MI302_01780	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MI302_01810	COG1802	Transcriptional regulator
MI302_01815	COG0506	proline dehydrogenase activity
MI302_01820	COG1012	belongs to the aldehyde dehydrogenase family
MI302_01825	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MI302_01830	COG0512	Glutamine amidotransferase of anthranilate synthase
MI302_01840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
MI302_01850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MI302_01855	COG1187	pseudouridine synthase activity
MI302_01860	COG1024	Enoyl-CoA hydratase
MI302_01865	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MI302_01870	COG0686	Belongs to the AlaDH PNT family
MI302_01880	COG1461	Dihydroxyacetone kinase
MI302_01910	COG0049	tRNA binding
MI302_01925	COG0051	transcription antitermination factor activity, RNA binding
MI302_01935	COG0088	Forms part of the polypeptide exit tunnel
MI302_01940	COG0089	rRNA binding
MI302_01945	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MI302_01950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
MI302_01960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MI302_01965	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MI302_01970	COG0255	Belongs to the universal ribosomal protein uL29 family
MI302_02030	COG0201	protein transport
MI302_02035	COG0563	adenylate kinase activity
MI302_02045	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
MI302_02055	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MI302_02060	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MI302_02065	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MI302_02075	COG0203	ribosomal protein L17
MI302_02110	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MI302_02115	COG0142	geranyltranstransferase activity
MI302_02120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MI302_02125	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MI302_02155	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MI302_02165	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MI302_02170	COG2385	sporulation resulting in formation of a cellular spore
MI302_02175	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MI302_02185	COG0194	GDP metabolic process
MI302_02195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MI302_02200	COG1438	arginine binding
MI302_02205	COG2095	MarC family integral membrane protein
MI302_02215	COG0497	DNA recombination
MI302_02225	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MI302_02235	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MI302_02240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MI302_02250	COG0047	phosphoribosylformylglycinamidine synthase activity
MI302_02260	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MI302_02265	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MI302_02270	COG0546	phosphoglycolate phosphatase activity
MI302_02285	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MI302_02315	COG5002	protein histidine kinase activity
MI302_02325	COG1272	protein, Hemolysin III
MI302_02330	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MI302_02330	COG0574	Belongs to the PEP-utilizing enzyme family
MI302_02335	COG0714	Associated with various cellular activities
MI302_02340	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MI302_02345	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
MI302_02355	COG0483	inositol monophosphate 1-phosphatase activity
MI302_02360	COG0135	phosphoribosylanthranilate isomerase activity
MI302_02370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MI302_02375	COG0537	adenosine 5'-monophosphoramidase activity
MI302_02390	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MI302_02400	COG1011	Hydrolase
MI302_02405	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MI302_02425	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MI302_02430	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MI302_02460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MI302_02465	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MI302_02470	COG0113	porphobilinogen synthase activity
MI302_02485	COG0631	protein serine/threonine phosphatase activity
MI302_02490	COG2815	serine threonine protein kinase
MI302_02490	COG0515	serine threonine protein kinase
MI302_02500	COG2205	protein histidine kinase activity
MI302_02525	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MI302_02530	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MI302_02535	COG0504	CTP synthase activity
MI302_02555	COG0277	FAD linked oxidase domain protein
MI302_02585	COG2002	toxin-antitoxin pair type II binding
MI302_02595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MI302_02610	COG4555	ABC transporter
MI302_02615	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MI302_02625	COG0667	Aldo Keto reductase
MI302_02645	COG1067	ATP-dependent peptidase activity
MI302_02650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MI302_02660	COG0745	RESPONSE REGULATOR receiver
MI302_02665	COG2105	PFAM AIG2 family protein
MI302_02680	COG0297	glycogen (starch) synthase activity
MI302_02690	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MI302_02695	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MI302_02710	COG0142	geranyltranstransferase activity
MI302_02720	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MI302_02945	COG0517	IMP dehydrogenase activity
MI302_02945	COG0516	GMP reductase activity
MI302_02965	COG2205	protein histidine kinase activity
MI302_02985	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MI302_03000	COG1324	tolerance protein
MI302_03005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MI302_03010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MI302_03015	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MI302_03020	COG2197	response regulator
MI302_03060	COG1132	(ABC) transporter
MI302_03065	COG1132	(ABC) transporter
MI302_03070	COG0285	dihydrofolate synthase activity
MI302_03080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MI302_03085	COG0601	transmembrane transport
MI302_03090	COG0747	negative chemotaxis
MI302_03120	COG0174	glutamine synthetase
MI302_03125	COG0737	Belongs to the 5'-nucleotidase family
MI302_03135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MI302_03140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MI302_03145	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
MI302_03150	COG0788	formyltetrahydrofolate deformylase activity
MI302_03165	COG2358	TRAP transporter, solute receptor (TAXI family
MI302_03185	COG2814	Major facilitator Superfamily
MI302_03190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MI302_03195	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MI302_03200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MI302_03210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MI302_03220	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MI302_03240	COG0247	lactate metabolic process
MI302_03245	COG0277	FAD linked oxidase domain protein
MI302_03250	COG0277	FAD linked oxidase domain protein
MI302_03255	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
MI302_03260	COG1414	Transcriptional regulator
MI302_03265	COG0789	Transcriptional regulator
MI302_03275	COG2045	Belongs to the ComB family
MI302_03280	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MI302_03285	COG1136	(ABC) transporter
MI302_03290	COG0813	purine-nucleoside phosphorylase activity
MI302_03295	COG1024	Enoyl-CoA hydratase
MI302_03305	COG0318	PFAM AMP-dependent synthetase and ligase
MI302_03330	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MI302_03380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MI302_03395	COG2890	protein-(glutamine-N5) methyltransferase activity
MI302_03400	COG1837	Belongs to the UPF0109 family
MI302_03405	COG0706	membrane insertase activity
MI302_03410	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MI302_03430	COG0318	PFAM AMP-dependent synthetase and ligase
MI302_03470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MI302_03475	COG0232	Belongs to the dGTPase family. Type 2 subfamily
MI302_03480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MI302_03485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MI302_03490	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_03495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MI302_03500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MI302_03505	COG0333	Belongs to the bacterial ribosomal protein bL32 family
MI302_03530	COG1007	ATP synthesis coupled electron transport
MI302_03535	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MI302_03540	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MI302_03545	COG0713	ATP synthesis coupled electron transport
MI302_03550	COG0839	Belongs to the complex I subunit 6 family
MI302_03555	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MI302_03560	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
MI302_03565	COG1034	ATP synthesis coupled electron transport
MI302_03570	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MI302_03575	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
MI302_03580	COG0649	NAD binding
MI302_03585	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MI302_03590	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MI302_03595	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MI302_03600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MI302_03610	COG4712	double-strand break repair protein
MI302_03625	COG0582	viral genome integration into host DNA
MI302_03635	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MI302_03710	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
MI302_03890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MI302_03895	COG0131	Imidazoleglycerol-phosphate dehydratase
MI302_03900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MI302_03905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MI302_03910	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MI302_03935	COG0586	Pfam SNARE associated Golgi protein
MI302_03940	COG0861	Integral membrane protein TerC family
MI302_03945	COG2151	metal-sulfur cluster biosynthetic enzyme
MI302_03950	COG1714	RDD family
MI302_03955	COG0616	signal peptide processing
MI302_03960	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MI302_03965	COG0372	Belongs to the citrate synthase family
MI302_03970	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MI302_03980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MI302_03985	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MI302_03985	COG0758	DNA mediated transformation
MI302_03990	COG3546	catalase activity
MI302_03995	COG0583	DNA-binding transcription factor activity
MI302_04005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MI302_04010	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MI302_04015	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MI302_04025	COG0717	Belongs to the dCTP deaminase family
MI302_04040	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_04045	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MI302_04070	COG0515	serine threonine protein kinase
MI302_04070	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MI302_04080	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MI302_04100	COG0704	Plays a role in the regulation of phosphate uptake
MI302_04105	COG2205	protein histidine kinase activity
MI302_04110	COG0745	RESPONSE REGULATOR receiver
MI302_04125	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MI302_04130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
MI302_04135	COG0248	Ppx GppA phosphatase
MI302_04160	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MI302_04165	COG0509	glycine decarboxylation via glycine cleavage system
MI302_04170	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MI302_04175	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MI302_04180	COG0196	riboflavin kinase activity
MI302_04200	COG2813	Specifically methylates the guanine in position
MI302_04210	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
MI302_04220	COG0358	DNA primase activity
MI302_04235	COG1111	helicase
MI302_04235	COG1205	dead DEAH box helicase
MI302_04260	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MI302_04265	COG0009	L-threonylcarbamoyladenylate synthase
MI302_04270	COG1459	type II secretion system
MI302_04280	COG0277	FAD linked oxidase domain protein
MI302_04290	COG0287	Prephenate dehydrogenase
MI302_04295	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MI302_04300	COG2514	catechol 2,3-dioxygenase activity
MI302_04310	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
MI302_04315	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MI302_04335	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MI302_04340	COG0179	Fumarylacetoacetate (FAA) hydrolase
MI302_04350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MI302_04355	COG0151	Belongs to the GarS family
MI302_04380	COG2205	protein histidine kinase activity
MI302_04390	COG0517	IMP dehydrogenase activity
MI302_04390	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MI302_04390	COG0617	tRNA 3'-terminal CCA addition
MI302_04420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MI302_04430	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MI302_04435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MI302_04440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MI302_04450	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MI302_04450	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MI302_04460	COG1733	regulation of RNA biosynthetic process
MI302_04465	COG2894	cell division
MI302_04470	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
MI302_04475	COG0772	Belongs to the SEDS family
MI302_04480	COG3842	ATPase activity
MI302_04485	COG1176	ABC-type spermidine putrescine transport system, permease component I
MI302_04490	COG1177	transmembrane transport
MI302_04495	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
MI302_04500	COG2010	Cytochrome c
MI302_04505	COG0129	dihydroxy-acid dehydratase activity
MI302_04510	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_04525	COG0066	3-isopropylmalate dehydratase activity
MI302_04530	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MI302_04545	COG0180	Tryptophanyl-tRNA synthetase
MI302_04565	COG3335	DDE superfamily endonuclease
MI302_04575	COG2165	general secretion pathway protein
MI302_04595	COG4966	pilus assembly protein PilW
MI302_04600	COG2165	general secretion pathway protein
MI302_04605	COG4970	Tfp pilus assembly protein FimT
MI302_04610	COG4970	Tfp pilus assembly protein FimT
MI302_04615	COG0183	Belongs to the thiolase family
MI302_04625	COG2361	Protein of unknown function DUF86
MI302_04640	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MI302_04645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MI302_04660	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MI302_04665	COG1254	Belongs to the acylphosphatase family
MI302_04675	COG1063	alcohol dehydrogenase
MI302_04680	COG2133	pyrroloquinoline quinone binding
MI302_04685	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MI302_04715	COG0419	ATPase involved in DNA repair
MI302_04730	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MI302_04735	COG0612	Peptidase, M16
MI302_04740	COG0612	Peptidase, M16
MI302_04765	COG1250	3-hydroxyacyl-CoA dehydrogenase
MI302_04785	COG4956	integral membrane protein (PIN domain superfamily)
MI302_04790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MI302_04795	COG0542	response to heat
MI302_04800	COG0423	glycine-tRNA ligase activity
MI302_04810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MI302_04815	COG1609	Transcriptional regulator
MI302_04835	COG3842	ATPase activity
MI302_04860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MI302_04860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MI302_04865	COG1024	Enoyl-CoA hydratase
MI302_04870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MI302_04880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MI302_04890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MI302_04895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MI302_04900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MI302_04925	COG0861	Integral membrane protein TerC family
MI302_04930	COG0492	ferredoxin-NADP+ reductase activity
MI302_04935	COG0028	Belongs to the TPP enzyme family
MI302_04940	COG0440	acetolactate synthase activity
MI302_04945	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MI302_04955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MI302_04970	COG4555	ABC transporter
MI302_05000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MI302_05010	COG1573	uracil-dna glycosylase
MI302_05030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MI302_05050	COG1316	TRANSCRIPTIONal
MI302_05085	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MI302_05100	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MI302_05110	COG1269	ATP hydrolysis coupled proton transport
MI302_05120	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
MI302_05125	COG1527	subunit (C
MI302_05130	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
MI302_05135	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
MI302_05140	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
MI302_05145	COG1394	ATPase activity, coupled to movement of substances
MI302_05150	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MI302_05200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MI302_05210	COG1760	l-serine dehydratase
MI302_05220	COG0481	GTPase activity
MI302_05230	COG1960	acyl-CoA dehydrogenase activity
MI302_05235	COG0183	Belongs to the thiolase family
MI302_05245	COG1804	L-carnitine dehydratase bile acid-inducible protein F
MI302_05255	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_05270	COG0559	Belongs to the binding-protein-dependent transport system permease family
MI302_05275	COG0559	Belongs to the binding-protein-dependent transport system permease family
MI302_05285	COG2030	dehydratase
MI302_05295	COG0596	Alpha beta hydrolase
MI302_05305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MI302_05310	COG2909	trisaccharide binding
MI302_05315	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MI302_05315	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MI302_05325	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MI302_05335	COG0195	Participates in both transcription termination and antitermination
MI302_05340	COG0779	Required for maturation of 30S ribosomal subunits
MI302_05350	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MI302_05350	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MI302_05360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MI302_05360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MI302_05380	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MI302_05380	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MI302_05385	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MI302_05385	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
MI302_05390	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MI302_05410	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MI302_05415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MI302_05420	COG1702	phosphate starvation-inducible protein PhoH
MI302_05430	COG4864	UPF0365 protein
MI302_05440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MI302_05455	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MI302_05460	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MI302_05465	COG0824	Thioesterase
MI302_05475	COG0557	exoribonuclease II activity
MI302_05480	COG1355	regulation of microtubule-based process
MI302_05485	COG0617	tRNA 3'-terminal CCA addition
MI302_05485	COG1353	crispr-associated protein
MI302_05490	COG0237	dephospho-CoA kinase activity
MI302_05495	COG4221	oxidoreductase activity
MI302_05505	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MI302_05540	COG0165	Argininosuccinate lyase
MI302_05545	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MI302_05570	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MI302_05575	COG1185	polyribonucleotide nucleotidyltransferase activity
MI302_05580	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MI302_05595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MI302_05600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MI302_05610	COG1100	Small GTP-binding protein
MI302_05625	COG0010	Belongs to the arginase family
MI302_05645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MI302_05650	COG0511	ligase activity, forming carbon-carbon bonds
MI302_05655	COG0439	Biotin carboxylase
MI302_05665	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MI302_05670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MI302_05675	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MI302_05685	COG0247	lactate metabolic process
MI302_05685	COG2181	nitrate reductase activity
MI302_05700	COG2819	hydrolase of the alpha beta superfamily
MI302_05710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MI302_05715	COG0438	transferase activity, transferring glycosyl groups
MI302_05750	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MI302_05755	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MI302_05765	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MI302_05790	COG0582	viral genome integration into host DNA
MI302_05800	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MI302_05875	COG3845	ABC transporter
MI302_05880	COG4603	Belongs to the binding-protein-dependent transport system permease family
MI302_05885	COG1079	Belongs to the binding-protein-dependent transport system permease family
MI302_05895	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MI302_05900	COG0494	nUDIX hydrolase
MI302_05910	COG0138	bifunctional purine biosynthesis protein purh
MI302_05920	COG2337	Toxic component of a toxin-antitoxin (TA) module
MI302_05925	COG3239	Fatty acid desaturase
MI302_05930	COG1490	D-aminoacyl-tRNA deacylase activity
MI302_05935	COG1307	EDD domain protein, DegV family
MI302_05940	COG1307	EDD domain protein, DegV family
MI302_05945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MI302_05960	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MI302_05970	COG1012	belongs to the aldehyde dehydrogenase family
MI302_05975	COG2368	4-hydroxyphenylacetate
MI302_05980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MI302_06010	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
MI302_06025	COG1492	cobalamin metabolic process
MI302_06055	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MI302_06060	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MI302_06070	COG0628	permease
MI302_06080	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
MI302_06085	COG0588	phosphoglycerate mutase activity
MI302_06100	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
MI302_06105	COG1492	cobalamin metabolic process
MI302_06110	COG1116	anion transmembrane transporter activity
MI302_06115	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MI302_06120	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MI302_06135	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MI302_06140	COG1648	precorrin-2 dehydrogenase activity
MI302_06140	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MI302_06145	COG1648	precorrin-2 dehydrogenase activity
MI302_06145	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MI302_06150	COG0243	molybdopterin cofactor binding
MI302_06155	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MI302_06175	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MI302_06180	COG1607	acyl-coa hydrolase
MI302_06185	COG1785	Belongs to the alkaline phosphatase family
MI302_06205	COG1797	cobyrinic acid a,c-diamide synthase activity
MI302_06210	COG2046	Belongs to the sulfate adenylyltransferase family
MI302_06215	COG1648	precorrin-2 dehydrogenase activity
MI302_06215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MI302_06220	COG0730	response to heat
MI302_06225	COG0175	sulfate reduction
MI302_06230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MI302_06230	COG1648	precorrin-2 dehydrogenase activity
MI302_06235	COG1587	Uroporphyrinogen-III synthase
MI302_06240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MI302_06245	COG0352	thiamine-phosphate diphosphorylase activity
MI302_06250	COG2104	thiamine diphosphate biosynthetic process
MI302_06255	COG2022	thiamine diphosphate biosynthetic process
MI302_06260	COG2022	thiamine diphosphate biosynthetic process
MI302_06260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MI302_06265	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MI302_06270	COG0477	Major facilitator Superfamily
MI302_06275	COG0351	phosphomethylpyrimidine kinase
MI302_06275	COG0352	thiamine-phosphate diphosphorylase activity
MI302_06280	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_06285	COG0318	PFAM AMP-dependent synthetase and ligase
MI302_06295	COG2030	dehydratase
MI302_06295	COG1012	belongs to the aldehyde dehydrogenase family
MI302_06300	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_06315	COG0411	ABC transporter
MI302_06335	COG1960	acyl-CoA dehydrogenase activity
MI302_06340	COG1309	transcriptional regulator
MI302_06350	COG1980	fructose-bisphosphate aldolase activity
MI302_06355	COG0405	Gamma-glutamyltransferase
MI302_06370	COG4974	Belongs to the 'phage' integrase family
MI302_06380	COG3396	Phenylacetate-CoA oxygenase
MI302_06390	COG3396	Phenylacetate-CoA oxygenase
MI302_06400	COG1012	belongs to the aldehyde dehydrogenase family
MI302_06400	COG2030	dehydratase
MI302_06405	COG1733	regulation of RNA biosynthetic process
MI302_06410	COG2193	ferroxidase activity
MI302_06420	COG1331	Highly conserved protein containing a thioredoxin domain
MI302_06425	COG0183	Belongs to the thiolase family
MI302_06430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MI302_06440	COG2414	aldehyde ferredoxin oxidoreductase
MI302_06450	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MI302_06455	COG0803	Belongs to the bacterial solute-binding protein 9 family
MI302_06460	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MI302_06465	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
MI302_06480	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MI302_06495	COG1960	acyl-CoA dehydrogenase activity
MI302_06500	COG2086	electron transfer activity
MI302_06505	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MI302_06515	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MI302_06520	COG1573	uracil-dna glycosylase
MI302_06525	COG1796	DNA polymerase
MI302_06525	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MI302_06540	COG0674	pyruvate-flavodoxin oxidoreductase activity
MI302_06540	COG1013	pyruvate-flavodoxin oxidoreductase activity
MI302_06540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MI302_06540	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MI302_06555	COG2873	o-acetylhomoserine
MI302_06570	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MI302_06575	COG0215	cysteine-tRNA ligase activity
MI302_06580	COG1960	acyl-CoA dehydrogenase activity
MI302_06585	COG0183	Belongs to the thiolase family
MI302_06590	COG1250	3-hydroxyacyl-CoA dehydrogenase
MI302_06590	COG1024	Enoyl-CoA hydratase
MI302_06595	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MI302_06605	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MI302_06610	COG0438	transferase activity, transferring glycosyl groups
MI302_06615	COG0438	transferase activity, transferring glycosyl groups
MI302_06625	COG1215	transferase activity, transferring glycosyl groups
MI302_06630	COG2814	Major facilitator Superfamily
MI302_06640	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MI302_06640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MI302_06645	COG1811	Na channel or pump
MI302_06650	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MI302_06655	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MI302_06660	COG4948	Mandelate Racemase Muconate Lactonizing
MI302_06670	COG0402	S-adenosylhomocysteine deaminase activity
MI302_06695	COG2319	Wd-40 repeat
MI302_06705	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MI302_06710	COG0742	ribosomal rna small subunit methyltransferase
MI302_06725	COG2873	o-acetylhomoserine
MI302_06730	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
MI302_06735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MI302_06740	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MI302_06800	COG0149	triose-phosphate isomerase activity
MI302_06805	COG0126	phosphoglycerate kinase activity
MI302_06815	COG1268	BioY protein
MI302_06825	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MI302_06840	COG1196	nuclear chromosome segregation
MI302_06855	COG2738	Putative neutral zinc metallopeptidase
MI302_06860	COG2897	thiosulfate sulfurtransferase activity
MI302_06865	COG1760	l-serine dehydratase
MI302_06870	COG2197	response regulator
MI302_06875	COG0335	large ribosomal subunit rRNA binding
MI302_06880	COG0336	Belongs to the RNA methyltransferase TrmD family
MI302_06885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MI302_06895	COG0228	four-way junction DNA binding
MI302_06905	COG2239	Acts as a magnesium transporter
MI302_06915	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MI302_06930	COG1692	metallophosphoesterase
MI302_06955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MI302_06960	COG1410	methionine synthase
MI302_06960	COG0646	methionine synthase
MI302_06965	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MI302_06970	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MI302_06975	COG0740	serine-type endopeptidase activity
MI302_06980	COG0544	peptidyl-prolyl cis-trans isomerase activity
MI302_07015	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MI302_07020	COG3870	Protein conserved in bacteria
MI302_07025	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MI302_07035	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MI302_07045	COG4475	Protein of unknown function (DUF436)
MI302_07055	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
MI302_07065	COG1970	mechanosensitive ion channel activity
MI302_07070	COG3842	ATPase activity
MI302_07075	COG0572	uridine kinase
MI302_07095	COG2176	DNA-directed DNA polymerase activity
MI302_07100	COG0154	amidase activity
MI302_07105	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MI302_07115	COG1435	thymidine kinase activity
MI302_07125	COG0254	rRNA binding
MI302_07140	COG2001	Belongs to the MraZ family
MI302_07145	COG0275	rRNA processing
MI302_07155	COG0768	penicillin binding
MI302_07160	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MI302_07170	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MI302_07175	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MI302_07180	COG0772	Belongs to the SEDS family
MI302_07185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MI302_07190	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MI302_07195	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MI302_07215	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
MI302_07225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MI302_07235	COG1562	ergosterol biosynthetic process
MI302_07240	COG0415	Belongs to the DNA photolyase family
MI302_07270	COG1304	FMN binding
MI302_07305	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_07320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MI302_07355	COG1175	transmembrane transport
MI302_07385	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MI302_07390	COG2264	protein methyltransferase activity
MI302_07400	COG0489	protein tyrosine kinase activity
MI302_07415	COG0525	valine-tRNA ligase activity
MI302_07425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MI302_07435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MI302_07440	COG0134	indole-3-glycerol-phosphate synthase activity
MI302_07445	COG1752	Esterase of the alpha-beta hydrolase superfamily
MI302_07455	COG1126	abc transporter atp-binding protein
MI302_07465	COG2358	TRAP transporter, solute receptor (TAXI family
MI302_07470	COG0765	amino acid transport
MI302_07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MI302_07485	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MI302_07490	COG0569	domain protein
MI302_07495	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MI302_07505	COG2313	pseudouridylate synthase activity
MI302_07515	COG3001	Fructosamine kinase
MI302_07520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MI302_07525	COG4585	Histidine kinase
MI302_07555	COG0012	GTP binding
MI302_07560	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MI302_07570	COG0424	maF-like protein
MI302_07585	COG0768	penicillin binding
MI302_07595	COG2322	membrane
MI302_07615	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MI302_07620	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MI302_07630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MI302_07645	COG3842	ATPase activity
MI302_07655	COG0124	histidyl-tRNA synthetase
MI302_07665	COG0384	phenazine biosynthesis protein PhzF
MI302_07670	COG0561	phosphatase activity
MI302_07685	COG0017	Asparaginyl-tRNA synthetase
MI302_07690	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MI302_07695	COG2217	Heavy metal translocating P-type atpase
MI302_07700	COG0640	Transcriptional regulator
MI302_07705	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MI302_07710	COG0739	heme binding
MI302_07715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MI302_07720	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MI302_07725	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MI302_07730	COG0006	proline dipeptidase activity
MI302_07735	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MI302_07740	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MI302_07750	COG1994	Peptidase M50
MI302_07760	COG0517	IMP dehydrogenase activity
MI302_07760	COG0617	tRNA 3'-terminal CCA addition
MI302_07760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MI302_07785	COG0052	Belongs to the universal ribosomal protein uS2 family
MI302_07790	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MI302_07795	COG0528	UMP kinase activity
MI302_07800	COG0233	cytoplasmic translational termination
MI302_07805	COG4589	Belongs to the CDS family
MI302_07810	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MI302_07815	COG0750	zinc metalloprotease
MI302_07830	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MI302_07835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MI302_07840	COG2359	stage V sporulation protein S
MI302_07850	COG2137	regulation of response to DNA damage stimulus
MI302_07880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MI302_07885	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MI302_07900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MI302_07915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MI302_07920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MI302_07925	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MI302_07930	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MI302_07950	COG2151	metal-sulfur cluster biosynthetic enzyme
MI302_08000	COG2181	nitrate reductase activity
MI302_08015	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MI302_08030	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MI302_08035	COG2010	Cytochrome c
MI302_08040	COG0535	radical SAM domain protein
MI302_08080	COG1252	NADH dehydrogenase
MI302_08085	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MI302_08095	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MI302_08110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MI302_08115	COG3191	aminopeptidase activity
MI302_08125	COG1063	alcohol dehydrogenase
MI302_08150	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MI302_08155	COG2884	Cell division ATP-binding protein ftsE
MI302_08160	COG0793	Belongs to the peptidase S41A family
MI302_08165	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MI302_08165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MI302_08170	COG2361	Protein of unknown function DUF86
MI302_08180	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
MI302_08185	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MI302_08195	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
MI302_08205	COG0159	tryptophan synthase activity
MI302_08210	COG0133	tryptophan synthase activity
MI302_08215	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
MI302_08225	COG1744	ABC transporter substrate-binding protein PnrA-like
MI302_08230	COG3845	ABC transporter
MI302_08260	COG1605	Chorismate mutase
MI302_08260	COG0077	Prephenate dehydratase
MI302_08265	COG0517	IMP dehydrogenase activity
MI302_08280	COG1674	ftsk spoiiie
MI302_08285	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MI302_08290	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MI302_08295	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MI302_08305	COG0217	transcriptional regulatory protein
MI302_08310	COG0653	protein targeting
MI302_08315	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MI302_08355	COG0312	modulator of DNA gyrase
MI302_08360	COG0312	modulator of DNA gyrase
MI302_08375	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MI302_08380	COG0730	response to heat
MI302_08410	COG0167	dihydroorotate dehydrogenase activity
MI302_08420	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MI302_08425	COG0746	molybdenum cofactor guanylyltransferase activity
MI302_08430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MI302_08430	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
MI302_08440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MI302_08535	COG2189	Belongs to the N(4) N(6)-methyltransferase family
MI302_08550	COG0582	viral genome integration into host DNA
MI302_08570	COG0538	isocitrate dehydrogenase activity
MI302_08575	COG0557	exoribonuclease II activity
MI302_08585	COG0585	pseudouridine synthase activity
MI302_08605	COG2050	protein possibly involved in aromatic compounds catabolism
MI302_08615	COG0322	excinuclease ABC activity
MI302_08620	COG0018	arginyl-trna synthetase
MI302_08625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MI302_08630	COG1428	Deoxynucleoside kinase
MI302_08635	COG1428	Deoxynucleoside kinase
MI302_08640	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MI302_08645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MI302_08655	COG0107	imidazoleglycerol-phosphate synthase activity
MI302_08660	COG0140	phosphoribosyl-ATP diphosphatase activity
MI302_08660	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MI302_08670	COG1494	fructose-1,6-bisphosphatase
MI302_08695	COG0395	ABC-type sugar transport system, permease component
MI302_08700	COG1175	transmembrane transport
MI302_08725	COG0084	hydrolase, TatD family'
MI302_08730	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MI302_08740	COG0017	Asparaginyl-tRNA synthetase
MI302_08745	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MI302_08760	COG2009	succinate dehydrogenase
MI302_08765	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MI302_08795	COG0318	PFAM AMP-dependent synthetase and ligase
MI302_08800	COG1104	cysteine desulfurase activity
MI302_08810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MI302_08820	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MI302_08825	COG2255	four-way junction helicase activity
MI302_08845	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MI302_08850	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MI302_08875	COG1085	galactose-1-phosphate uridylyltransferase
MI302_08880	COG3345	alpha-galactosidase
MI302_08895	COG1175	transmembrane transport
MI302_08900	COG1653	transport
MI302_08905	COG1349	DNA-binding transcription factor activity
MI302_08920	COG2211	Major facilitator Superfamily
MI302_08930	COG1181	Belongs to the D-alanine--D-alanine ligase family
MI302_08935	COG3335	DDE superfamily endonuclease
MI302_08945	COG0193	aminoacyl-tRNA hydrolase activity
MI302_08950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MI302_08955	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MI302_08960	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MI302_08965	COG1854	S-ribosylhomocysteine lyase activity
MI302_08980	COG0519	Catalyzes the synthesis of GMP from XMP
MI302_08980	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MI302_08985	COG4636	protein conserved in cyanobacteria
MI302_08990	COG4274	PFAM GYD family protein
MI302_09005	COG0328	RNA-DNA hybrid ribonuclease activity
MI302_09010	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MI302_09045	COG0037	tRNA processing
MI302_09045	COG0590	tRNA wobble adenosine to inosine editing
MI302_09065	COG0366	Alpha amylase catalytic
MI302_09080	COG0815	Transfers the fatty acyl group on membrane lipoproteins
MI302_09090	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MI302_09095	COG0460	homoserine dehydrogenase
MI302_09100	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MI302_09135	COG0037	tRNA processing
MI302_09140	COG2104	thiamine diphosphate biosynthetic process
MI302_09145	COG0123	including yeast histone deacetylase and acetoin utilization protein
MI302_09150	COG0517	IMP dehydrogenase activity
MI302_09160	COG0444	Belongs to the ABC transporter superfamily
MI302_09165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MI302_09170	COG0601	transmembrane transport
MI302_09175	COG0747	negative chemotaxis
MI302_09205	COG0604	alcohol dehydrogenase
MI302_09210	COG0492	ferredoxin-NADP+ reductase activity
MI302_09240	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MI302_09245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MI302_09250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MI302_09270	COG2070	2-Nitropropane dioxygenase
MI302_09300	COG0745	RESPONSE REGULATOR receiver
MI302_09305	COG5002	protein histidine kinase activity
MI302_09325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MI302_09335	COG2045	Belongs to the ComB family
MI302_09340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MI302_09355	COG0513	Belongs to the DEAD box helicase family
MI302_09360	COG0303	'Molybdopterin
MI302_09380	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MI302_09430	COG0442	prolyl-tRNA aminoacylation
MI302_09435	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
MI302_09440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MI302_09475	COG1028	Short-chain dehydrogenase reductase Sdr
MI302_09480	COG2816	NAD+ diphosphatase activity
MI302_09485	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MI302_09485	COG1213	nucleotidyl transferase
MI302_09490	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MI302_09495	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MI302_09500	COG1482	cell wall glycoprotein biosynthetic process
MI302_09510	COG1515	deoxyribonuclease V activity
MI302_09520	COG0776	regulation of translation
MI302_09525	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MI302_09530	COG0443	Heat shock 70 kDa protein
MI302_09535	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MI302_09540	COG0484	heat shock protein binding
MI302_09545	COG0789	Transcriptional regulator
MI302_09550	COG0542	response to heat
MI302_09575	COG2193	ferroxidase activity
MI302_09580	COG0450	alkyl hydroperoxide reductase
MI302_09590	COG3118	belongs to the thioredoxin family
MI302_09610	COG0490	domain, Protein
MI302_09615	COG0475	glutathione-regulated potassium exporter activity
MI302_09630	COG1320	monovalent cation:proton antiporter activity
MI302_09635	COG2212	antiporter activity
MI302_09640	COG1863	multisubunit Na H antiporter MnhE subunit
MI302_09645	COG0651	ATP synthesis coupled electron transport
MI302_09650	COG1006	Multisubunit Na H antiporter MnhC subunit
MI302_09655	COG2111	Na H antiporter
MI302_09660	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MI302_09660	COG2111	Na H antiporter
MI302_09680	COG0070	glutamate synthase
MI302_09680	COG0069	glutamate synthase activity
MI302_09680	COG0067	glutamate synthase
MI302_09685	COG0247	lactate metabolic process
MI302_09690	COG1139	Iron-sulfur cluster binding protein
MI302_09695	COG1139	Iron-sulfur cluster binding protein
MI302_09705	COG1752	Esterase of the alpha-beta hydrolase superfamily
MI302_09710	COG0515	serine threonine protein kinase
MI302_09710	COG2815	serine threonine protein kinase
MI302_09715	COG0860	N-Acetylmuramoyl-L-alanine amidase
MI302_09725	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MI302_09765	COG0473	3-isopropylmalate dehydrogenase activity
MI302_09790	COG1450	Type ii and iii secretion system protein
MI302_09795	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MI302_09800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MI302_09805	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MI302_09810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
MI302_09810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MI302_09815	COG0736	holo-[acyl-carrier-protein] synthase activity
MI302_09835	COG1160	GTP binding
MI302_09850	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MI302_09855	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MI302_09855	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
MI302_09865	COG0083	homoserine kinase activity
MI302_09880	COG0268	Binds directly to 16S ribosomal RNA
MI302_09890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MI302_09895	COG0723	plastoquinol--plastocyanin reductase activity
MI302_09905	COG3088	subunit of a heme lyase
MI302_09905	COG4235	cytochrome complex assembly
MI302_09910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MI302_09920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
MI302_09925	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MI302_09935	COG4133	protoheme IX ABC transporter activity
MI302_09940	COG0785	Cytochrome C biogenesis protein
MI302_09950	COG3842	ATPase activity
MI302_09970	COG2154	pterin-4-alpha-carbinolamine dehydratase
MI302_09975	COG1607	acyl-coa hydrolase
MI302_09980	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MI302_09985	COG1177	transmembrane transport
MI302_10005	COG0235	Class ii aldolase
MI302_10045	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MI302_10050	COG1077	Cell shape determining protein MreB Mrl
MI302_10055	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MI302_10055	COG1418	mRNA catabolic process
MI302_10065	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MI302_10070	COG1546	Belongs to the CinA family
MI302_10070	COG1058	Belongs to the CinA family
MI302_10075	COG0354	folic acid binding
MI302_10090	COG4948	Mandelate Racemase Muconate Lactonizing
MI302_10115	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MI302_10125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MI302_10155	COG1136	(ABC) transporter
MI302_10155	COG0577	efflux transmembrane transporter activity
MI302_10160	COG1136	(ABC) transporter
MI302_10165	COG0446	pyridine nucleotide-disulphide oxidoreductase
MI302_10185	COG0719	Fe-S assembly protein
MI302_10190	COG0719	Fe-S assembly protein
MI302_10220	COG2217	Heavy metal translocating P-type atpase
MI302_10230	COG0745	RESPONSE REGULATOR receiver
MI302_10235	COG5002	protein histidine kinase activity
MI302_10250	COG2226	methyltransferase
MI302_10275	COG2132	Multicopper oxidase
MI302_10285	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MI302_10290	COG0822	iron-sulfur transferase activity
MI302_10305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MI302_10315	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MI302_10320	COG0284	orotidine-5'-phosphate decarboxylase activity
MI302_10335	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MI302_10345	COG0416	fatty acid biosynthetic process
MI302_10350	COG3118	belongs to the thioredoxin family
MI302_10355	COG1185	polyribonucleotide nucleotidyltransferase activity
MI302_10360	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MI302_10365	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MI302_10380	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MI302_10395	COG1252	NADH dehydrogenase
MI302_10420	COG0437	4 iron, 4 sulfur cluster binding
MI302_10455	COG1309	transcriptional regulator
MI302_10475	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MI302_10480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MI302_10485	COG1968	undecaprenyl-diphosphatase activity
MI302_10490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MI302_10495	COG0484	heat shock protein binding
MI302_10500	COG1278	Cold shock
MI302_10510	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
MI302_10535	COG0825	malonyl-CoA metabolic process
MI302_10540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MI302_10550	COG0739	heme binding
MI302_10595	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MI302_10605	COG4636	protein conserved in cyanobacteria
MI302_10610	COG0799	negative regulation of ribosome biogenesis
MI302_10625	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MI302_10630	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MI302_10635	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MI302_10640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MI302_10665	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MI302_10690	COG0438	transferase activity, transferring glycosyl groups
MI302_10765	COG2759	Belongs to the formate--tetrahydrofolate ligase family
MI302_10770	COG0505	Belongs to the CarA family
MI302_10785	COG0165	Argininosuccinate lyase
MI302_10790	COG0137	argininosuccinate synthase activity
MI302_10805	COG1404	Belongs to the peptidase S8 family
MI302_10815	COG0508	dehydrogenase complex catalyzes the overall conversion of
MI302_10835	COG1024	Enoyl-CoA hydratase
MI302_10840	COG0632	four-way junction helicase activity
MI302_10850	COG3253	May function as heme-dependent peroxidase
MI302_10855	COG0668	transmembrane transport
MI302_10865	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MI302_10870	COG0432	Pfam Uncharacterised protein family UPF0047
MI302_10875	COG2226	methyltransferase
MI302_10905	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MI302_10910	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MI302_10915	COG0022	dehydrogenase e1 component
MI302_10920	COG1598	PFAM Uncharacterised protein family UPF0150
MI302_10935	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MI302_10965	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MI302_10970	COG0321	lipoyl(octanoyl) transferase activity
MI302_10980	COG0300	oxidoreductase activity
MI302_10985	COG0359	binds to the 23S rRNA
MI302_10990	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MI302_11020	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
MI302_11040	COG2271	Major facilitator Superfamily
MI302_11045	COG3177	Filamentation induced by cAMP protein fic
MI302_11055	COG0606	chelatase, subunit chli
MI302_11060	COG1803	Methylglyoxal synthase
MI302_11065	COG1694	Mazg nucleotide pyrophosphohydrolase
MI302_11080	COG0477	Major facilitator Superfamily
MI302_11085	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MI302_11090	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MI302_11095	COG0778	Nitroreductase
MI302_11100	COG0791	NLP P60 protein
MI302_11100	COG1388	LysM domain
MI302_11115	COG0445	tRNA wobble uridine modification
MI302_11130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MI302_11135	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MI302_11135	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MI302_11140	COG1543	Belongs to the glycosyl hydrolase 57 family
MI302_11145	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MI302_11150	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MI302_11155	COG0189	ligase activity
MI302_11170	COG0066	3-isopropylmalate dehydratase activity
MI302_11175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MI302_11190	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MI302_11195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MI302_11200	COG1960	acyl-CoA dehydrogenase activity
MI302_11205	COG0163	prenyltransferase activity
MI302_11210	COG0222	ribosome binding
MI302_11215	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MI302_11220	COG0081	regulation of translation
MI302_11230	COG0250	Participates in transcription elongation, termination and antitermination
MI302_11235	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MI302_11240	COG0267	Belongs to the bacterial ribosomal protein bL33 family
MI302_11270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
MI302_11275	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MI302_11280	COG1335	isochorismatase
MI302_11300	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MI302_11310	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MI302_11315	COG1993	acr, cog1993
MI302_11320	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MI302_11330	COG1496	oxidoreductase activity
MI302_11335	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MI302_11360	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MI302_11365	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MI302_11370	COG0406	alpha-ribazole phosphatase activity
MI302_11390	COG1950	PFAM Membrane protein of
MI302_11395	COG0516	GMP reductase activity
MI302_11395	COG0517	IMP dehydrogenase activity
MI302_11405	COG2814	Major facilitator Superfamily
MI302_11420	COG0033	Phosphoglucomutase
MI302_11435	COG1653	transport
MI302_11450	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
MI302_11465	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MI302_11475	COG0243	molybdopterin cofactor binding
MI302_11485	COG0301	tRNA thio-modification
MI302_11490	COG0154	amidase activity
MI302_11495	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MI302_11510	COG0521	Mo-molybdopterin cofactor biosynthetic process
MI302_11515	COG0436	Aminotransferase
MI302_11520	COG0285	dihydrofolate synthase activity
MI302_11530	COG0181	hydroxymethylbilane synthase activity
MI302_11535	COG0508	dehydrogenase complex catalyzes the overall conversion of
MI302_11540	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
MI302_11565	COG0735	belongs to the Fur family
MI302_11570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MI302_11580	COG0482	sulfurtransferase activity
MI302_11590	COG0573	inorganic phosphate transmembrane transporter activity
MI302_11595	COG0581	inorganic phosphate transmembrane transporter activity
MI302_11600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MI302_11605	COG2814	Major facilitator Superfamily
MI302_11610	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MI302_11640	COG1845	cytochrome c oxidase, subunit III
MI302_11640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MI302_11645	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MI302_11650	COG0109	protoheme IX farnesyltransferase activity
MI302_11650	COG1612	heme a metabolic process
MI302_11655	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MI302_11660	COG0166	Belongs to the GPI family
MI302_11670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MI302_11675	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
MI302_11680	COG0459	protein refolding
MI302_11700	COG1013	pyruvate-flavodoxin oxidoreductase activity
MI302_11705	COG0674	pyruvate-flavodoxin oxidoreductase activity
MI302_11705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
MI302_11715	COG1937	Protein conserved in bacteria
MI302_11720	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MI302_11730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
MI302_11735	COG0693	protein deglycase activity
MI302_11745	COG3956	TIGRFAM MazG family protein
MI302_11785	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MI302_11800	COG1902	pentaerythritol trinitrate reductase activity
MI302_11815	COG0604	alcohol dehydrogenase
MI302_11825	COG2414	aldehyde ferredoxin oxidoreductase
MI302_11870	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MI302_11875	COG2860	membrane
MI302_11895	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
MI302_11905	COG1278	Cold shock
MI302_11915	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MI302_11940	COG1842	Phage shock protein A
MI302_11955	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MI302_11975	COG2010	Cytochrome c
MI302_11995	COG0315	cyclic pyranopterin monophosphate synthase activity
MI302_12025	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MI302_12035	COG0105	UTP biosynthetic process
MI302_12040	COG0631	protein serine/threonine phosphatase activity
MI302_12060	COG0148	phosphopyruvate hydratase activity