locus-tag	class	description
TthAA11_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthAA11_00020	COG0592	DNA-directed DNA polymerase activity
TthAA11_00030	COG0148	phosphopyruvate hydratase activity
TthAA11_00040	COG0469	pyruvate kinase activity
TthAA11_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA11_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthAA11_00090	COG1842	Phage shock protein A
TthAA11_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthAA11_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA11_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthAA11_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthAA11_00180	COG1496	oxidoreductase activity
TthAA11_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA11_00200	COG1278	Cold shock
TthAA11_00230	COG1653	transport
TthAA11_00260	COG0033	Phosphoglucomutase
TthAA11_00300	COG0517	IMP dehydrogenase activity
TthAA11_00300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthAA11_00310	COG1950	PFAM Membrane protein of
TthAA11_00320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthAA11_00330	COG1047	Peptidyl-prolyl cis-trans
TthAA11_00340	COG0181	hydroxymethylbilane synthase activity
TthAA11_00360	COG0285	dihydrofolate synthase activity
TthAA11_00370	COG0436	Aminotransferase
TthAA11_00380	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthAA11_00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthAA11_00440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthAA11_00450	COG1993	acr, cog1993
TthAA11_00460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthAA11_00480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA11_00500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthAA11_00510	COG1335	isochorismatase
TthAA11_00520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthAA11_00550	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthAA11_00560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthAA11_00600	COG1660	Displays ATPase and GTPase activities
TthAA11_00610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthAA11_00720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA11_00720	COG1845	cytochrome c oxidase, subunit III
TthAA11_00730	COG2010	Cytochrome c
TthAA11_00730	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAA11_00740	COG0109	protoheme IX farnesyltransferase activity
TthAA11_00740	COG1612	heme a metabolic process
TthAA11_00770	COG0343	queuine tRNA-ribosyltransferase activity
TthAA11_00780	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthAA11_00790	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthAA11_00900	COG1940	carbohydrate kinase activity
TthAA11_00920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA11_00930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA11_00940	COG0589	response to stress
TthAA11_00950	COG1611	Belongs to the LOG family
TthAA11_00970	COG1011	Hydrolase
TthAA11_00980	COG0632	four-way junction helicase activity
TthAA11_00990	COG1024	Enoyl-CoA hydratase
TthAA11_01010	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA11_01030	COG3335	DDE superfamily endonuclease
TthAA11_01050	COG1404	Belongs to the peptidase S8 family
TthAA11_01070	COG0137	argininosuccinate synthase activity
TthAA11_01080	COG0165	Argininosuccinate lyase
TthAA11_01100	COG0505	Belongs to the CarA family
TthAA11_01110	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TthAA11_01130	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthAA11_01140	COG0166	Belongs to the GPI family
TthAA11_01170	COG0714	Associated with various cellular activities
TthAA11_01200	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA11_01210	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthAA11_01220	COG0459	protein refolding
TthAA11_01230	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthAA11_01240	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthAA11_01260	COG0778	Nitroreductase
TthAA11_01270	COG1388	LysM domain
TthAA11_01270	COG0791	NLP P60 protein
TthAA11_01290	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthAA11_01310	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthAA11_01320	COG0581	inorganic phosphate transmembrane transporter activity
TthAA11_01330	COG0573	inorganic phosphate transmembrane transporter activity
TthAA11_01350	COG0482	sulfurtransferase activity
TthAA11_01370	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthAA11_01380	COG0735	belongs to the Fur family
TthAA11_01410	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthAA11_01420	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA11_01430	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthAA11_01440	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthAA11_01450	COG0250	Participates in transcription elongation, termination and antitermination
TthAA11_01470	COG0081	regulation of translation
TthAA11_01490	COG0629	single-stranded DNA binding
TthAA11_01500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthAA11_01510	COG0359	binds to the 23S rRNA
TthAA11_01550	COG0300	oxidoreductase activity
TthAA11_01560	COG0321	lipoyl(octanoyl) transferase activity
TthAA11_01570	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthAA11_01620	COG1476	TRANSCRIPTIONal
TthAA11_01660	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthAA11_01690	COG1598	PFAM Uncharacterised protein family UPF0150
TthAA11_01700	COG0022	dehydrogenase e1 component
TthAA11_01710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthAA11_01720	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthAA11_01770	COG2226	methyltransferase
TthAA11_01780	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthAA11_01800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthAA11_01810	COG1187	pseudouridine synthase activity
TthAA11_01830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthAA11_01840	COG0686	Belongs to the AlaDH PNT family
TthAA11_01860	COG1461	Dihydroxyacetone kinase
TthAA11_01890	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthAA11_01900	COG0222	ribosome binding
TthAA11_01910	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthAA11_01930	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthAA11_01960	COG0697	spore germination
TthAA11_02000	COG3177	Filamentation induced by cAMP protein fic
TthAA11_02020	COG0243	molybdopterin cofactor binding
TthAA11_02040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthAA11_02060	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA11_02090	COG0477	Major facilitator Superfamily
TthAA11_02120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthAA11_02140	COG0105	UTP biosynthetic process
TthAA11_02150	COG0631	protein serine/threonine phosphatase activity
TthAA11_02160	COG0583	DNA-binding transcription factor activity
TthAA11_02180	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA11_02240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA11_02260	COG1278	Cold shock
TthAA11_02270	COG0484	heat shock protein binding
TthAA11_02280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthAA11_02290	COG1968	undecaprenyl-diphosphatase activity
TthAA11_02300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthAA11_02310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthAA11_02340	COG1309	transcriptional regulator
TthAA11_02350	COG4242	Belongs to the peptidase S51 family
TthAA11_02380	COG0802	atpase or kinase
TthAA11_02390	COG0539	negative regulation of cytoplasmic translation
TthAA11_02400	COG0495	leucyl-tRNA aminoacylation
TthAA11_02440	COG1902	pentaerythritol trinitrate reductase activity
TthAA11_02490	COG2414	aldehyde ferredoxin oxidoreductase
TthAA11_02510	COG2165	general secretion pathway protein
TthAA11_02530	COG2165	general secretion pathway protein
TthAA11_02590	COG1459	type II secretion system
TthAA11_02610	COG1187	pseudouridine synthase activity
TthAA11_02630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA11_02640	COG0745	RESPONSE REGULATOR receiver
TthAA11_02650	COG4191	Histidine kinase
TthAA11_02660	COG0704	Plays a role in the regulation of phosphate uptake
TthAA11_02670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthAA11_02690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthAA11_02710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthAA11_02710	COG0515	serine threonine protein kinase
TthAA11_02770	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthAA11_02780	COG4221	oxidoreductase activity
TthAA11_02810	COG0717	Belongs to the dCTP deaminase family
TthAA11_02820	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthAA11_02830	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthAA11_02840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA11_02880	COG0583	DNA-binding transcription factor activity
TthAA11_02890	COG3546	catalase activity
TthAA11_02900	COG0758	DNA mediated transformation
TthAA11_02900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA11_02910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthAA11_02930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA11_02950	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthAA11_02970	COG0442	prolyl-tRNA aminoacylation
TthAA11_02980	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthAA11_03020	COG0303	'Molybdopterin
TthAA11_03030	COG0513	Belongs to the DEAD box helicase family
TthAA11_03040	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthAA11_03060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthAA11_03100	COG2070	2-Nitropropane dioxygenase
TthAA11_03130	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthAA11_03150	COG0018	arginyl-trna synthetase
TthAA11_03160	COG1007	ATP synthesis coupled electron transport
TthAA11_03170	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA11_03180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthAA11_03190	COG0713	ATP synthesis coupled electron transport
TthAA11_03200	COG0839	Belongs to the complex I subunit 6 family
TthAA11_03210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA11_03220	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthAA11_03230	COG1034	ATP synthesis coupled electron transport
TthAA11_03240	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthAA11_03250	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthAA11_03260	COG0649	NAD binding
TthAA11_03270	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA11_03280	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA11_03290	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA11_03300	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthAA11_03320	COG4712	double-strand break repair protein
TthAA11_03400	COG0135	phosphoribosylanthranilate isomerase activity
TthAA11_03420	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthAA11_03440	COG2720	vancomycin resistance protein
TthAA11_03450	COG1126	abc transporter atp-binding protein
TthAA11_03510	COG0277	FAD linked oxidase domain protein
TthAA11_03550	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthAA11_03560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthAA11_03590	COG0314	molybdopterin synthase activity
TthAA11_03600	COG1420	regulation of RNA biosynthetic process
TthAA11_03610	COG0347	Belongs to the P(II) protein family
TthAA11_03620	COG0004	ammonium transporteR
TthAA11_03640	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthAA11_03660	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA11_03690	COG1597	lipid kinase activity
TthAA11_03700	COG0436	Aminotransferase
TthAA11_03720	COG0569	domain protein
TthAA11_03720	COG0475	glutathione-regulated potassium exporter activity
TthAA11_03740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthAA11_03760	COG0277	FAD linked oxidase domain protein
TthAA11_03810	COG0667	Aldo Keto reductase
TthAA11_03870	COG1067	ATP-dependent peptidase activity
TthAA11_03880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthAA11_03900	COG0745	RESPONSE REGULATOR receiver
TthAA11_03910	COG2105	PFAM AIG2 family protein
TthAA11_03920	COG0297	glycogen (starch) synthase activity
TthAA11_03940	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthAA11_03950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthAA11_03980	COG0142	geranyltranstransferase activity
TthAA11_04000	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthAA11_04010	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA11_04020	COG0492	ferredoxin-NADP+ reductase activity
TthAA11_04040	COG0792	nuclease activity
TthAA11_04050	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthAA11_04080	COG1175	transmembrane transport
TthAA11_04090	COG0395	ABC-type sugar transport system, permease component
TthAA11_04150	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthAA11_04160	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthAA11_04170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthAA11_04180	COG0805	protein transport
TthAA11_04190	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA11_04190	COG1605	Chorismate mutase
TthAA11_04310	COG1063	alcohol dehydrogenase
TthAA11_04370	COG2255	four-way junction helicase activity
TthAA11_04380	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthAA11_04390	COG0564	pseudouridine synthase activity
TthAA11_04420	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthAA11_04430	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthAA11_04440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthAA11_04450	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthAA11_04470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthAA11_04480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthAA11_04490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthAA11_04560	COG0778	Nitroreductase
TthAA11_04600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthAA11_04610	COG0131	Imidazoleglycerol-phosphate dehydratase
TthAA11_04620	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthAA11_04630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAA11_04640	COG0516	GMP reductase activity
TthAA11_04640	COG0517	IMP dehydrogenase activity
TthAA11_04670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthAA11_04680	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA11_04710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA11_04750	COG0706	membrane insertase activity
TthAA11_04760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthAA11_04770	COG0594	ribonuclease P activity
TthAA11_04790	COG1022	Amp-dependent synthetase and ligase
TthAA11_04840	COG1121	(ABC) transporter
TthAA11_04850	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthAA11_04860	COG1959	2 iron, 2 sulfur cluster binding
TthAA11_04870	COG1104	cysteine desulfurase activity
TthAA11_04880	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthAA11_04890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthAA11_04920	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA11_04960	COG0492	ferredoxin-NADP+ reductase activity
TthAA11_04970	COG0604	alcohol dehydrogenase
TthAA11_04970	COG3321	synthase
TthAA11_04970	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA11_04980	COG0747	negative chemotaxis
TthAA11_04990	COG0601	transmembrane transport
TthAA11_05000	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA11_05030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA11_05030	COG0617	tRNA 3'-terminal CCA addition
TthAA11_05030	COG0517	IMP dehydrogenase activity
TthAA11_05040	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA11_05050	COG2104	thiamine diphosphate biosynthetic process
TthAA11_05060	COG0037	tRNA processing
TthAA11_05090	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthAA11_05140	COG4176	ABC-type proline glycine betaine transport system permease component
TthAA11_05150	COG3448	diguanylate cyclase activity
TthAA11_05150	COG4175	Glycine betaine
TthAA11_05160	COG0366	Alpha amylase catalytic
TthAA11_05170	COG2226	methyltransferase
TthAA11_05180	COG2226	methyltransferase
TthAA11_05190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthAA11_05210	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthAA11_05220	COG0460	homoserine dehydrogenase
TthAA11_05240	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthAA11_05310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthAA11_05350	COG0247	lactate metabolic process
TthAA11_05360	COG0277	FAD linked oxidase domain protein
TthAA11_05370	COG0277	FAD linked oxidase domain protein
TthAA11_05380	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthAA11_05390	COG1414	Transcriptional regulator
TthAA11_05400	COG0789	Transcriptional regulator
TthAA11_05420	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA11_05430	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA11_05500	COG0861	Integral membrane protein TerC family
TthAA11_05510	COG2151	metal-sulfur cluster biosynthetic enzyme
TthAA11_05520	COG0281	malic enzyme
TthAA11_05550	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthAA11_05560	COG0509	glycine decarboxylation via glycine cleavage system
TthAA11_05570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA11_05580	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA11_05590	COG0196	riboflavin kinase activity
TthAA11_05600	COG0494	nUDIX hydrolase
TthAA11_05640	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthAA11_05650	COG2813	Specifically methylates the guanine in position
TthAA11_05660	COG0527	aspartate kinase activity
TthAA11_05720	COG4956	integral membrane protein (PIN domain superfamily)
TthAA11_05730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthAA11_05740	COG0542	response to heat
TthAA11_05750	COG0423	glycine-tRNA ligase activity
TthAA11_05770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthAA11_05810	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA11_05810	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA11_05830	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthAA11_05850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthAA11_05870	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA11_05880	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA11_05890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthAA11_05900	COG0114	fumarate hydratase activity
TthAA11_05910	COG0183	Belongs to the thiolase family
TthAA11_05940	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthAA11_05950	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthAA11_05980	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthAA11_05990	COG1254	Belongs to the acylphosphatase family
TthAA11_06020	COG1063	alcohol dehydrogenase
TthAA11_06040	COG2133	pyrroloquinoline quinone binding
TthAA11_06060	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthAA11_06070	COG0154	amidase activity
TthAA11_06120	COG0572	uridine kinase
TthAA11_06130	COG3842	ATPase activity
TthAA11_06160	COG4475	Protein of unknown function (DUF436)
TthAA11_06200	COG1595	DNA-templated transcription, initiation
TthAA11_06320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA11_06330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthAA11_06340	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthAA11_06370	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthAA11_06380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthAA11_06390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthAA11_06420	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA11_06430	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA11_06440	COG2030	dehydratase
TthAA11_06440	COG1012	belongs to the aldehyde dehydrogenase family
TthAA11_06450	COG1960	acyl-CoA dehydrogenase activity
TthAA11_06480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthAA11_06490	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthAA11_06500	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthAA11_06520	COG3870	Protein conserved in bacteria
TthAA11_06530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthAA11_06550	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthAA11_06560	COG0740	serine-type endopeptidase activity
TthAA11_06570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthAA11_06580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthAA11_06590	COG0646	methionine synthase
TthAA11_06590	COG1410	methionine synthase
TthAA11_06600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA11_06660	COG1692	metallophosphoesterase
TthAA11_06670	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthAA11_06760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA11_06800	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthAA11_06820	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthAA11_06830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthAA11_06960	COG0438	transferase activity, transferring glycosyl groups
TthAA11_06990	COG0438	transferase activity, transferring glycosyl groups
TthAA11_07000	COG1215	transferase activity, transferring glycosyl groups
TthAA11_07030	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA11_07070	COG0489	protein tyrosine kinase activity
TthAA11_07090	COG2264	protein methyltransferase activity
TthAA11_07100	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthAA11_07160	COG0574	Belongs to the PEP-utilizing enzyme family
TthAA11_07160	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAA11_07180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthAA11_07190	COG2046	Belongs to the sulfate adenylyltransferase family
TthAA11_07200	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA11_07200	COG1648	precorrin-2 dehydrogenase activity
TthAA11_07210	COG0730	response to heat
TthAA11_07220	COG0175	sulfate reduction
TthAA11_07230	COG1648	precorrin-2 dehydrogenase activity
TthAA11_07230	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA11_07240	COG1587	Uroporphyrinogen-III synthase
TthAA11_07250	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthAA11_07300	COG0352	thiamine-phosphate diphosphorylase activity
TthAA11_07310	COG2104	thiamine diphosphate biosynthetic process
TthAA11_07320	COG2022	thiamine diphosphate biosynthetic process
TthAA11_07330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA11_07330	COG2022	thiamine diphosphate biosynthetic process
TthAA11_07340	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthAA11_07350	COG0477	Major facilitator Superfamily
TthAA11_07360	COG0351	phosphomethylpyrimidine kinase
TthAA11_07420	COG1175	transmembrane transport
TthAA11_07440	COG1940	carbohydrate kinase activity
TthAA11_07450	COG0183	Belongs to the thiolase family
TthAA11_07480	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA11_07550	COG1012	belongs to the aldehyde dehydrogenase family
TthAA11_07560	COG3835	regulator
TthAA11_07600	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA11_07620	COG2030	dehydratase
TthAA11_07640	COG0596	Alpha beta hydrolase
TthAA11_07650	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA11_07680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA11_07680	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA11_07700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthAA11_07720	COG0195	Participates in both transcription termination and antitermination
TthAA11_07730	COG0779	Required for maturation of 30S ribosomal subunits
TthAA11_07740	COG0739	heme binding
TthAA11_07750	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthAA11_07760	COG0640	Transcriptional regulator
TthAA11_07770	COG2217	Heavy metal translocating P-type atpase
TthAA11_07800	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthAA11_07810	COG0017	Asparaginyl-tRNA synthetase
TthAA11_07820	COG0561	phosphatase activity
TthAA11_07830	COG0384	phenazine biosynthesis protein PhzF
TthAA11_07850	COG0124	histidyl-tRNA synthetase
TthAA11_07870	COG3842	ATPase activity
TthAA11_07910	COG1573	uracil-dna glycosylase
TthAA11_07950	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthAA11_07960	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAA11_07960	COG0519	Catalyzes the synthesis of GMP from XMP
TthAA11_07980	COG1316	TRANSCRIPTIONal
TthAA11_07990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthAA11_08080	COG0295	cytidine deaminase activity
TthAA11_08120	COG1760	l-serine dehydratase
TthAA11_08140	COG0481	GTPase activity
TthAA11_08160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthAA11_08170	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthAA11_08190	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA11_08240	COG0405	Gamma-glutamyltransferase
TthAA11_08260	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthAA11_08270	COG2873	o-acetylhomoserine
TthAA11_08300	COG1063	alcohol dehydrogenase
TthAA11_08320	COG3191	aminopeptidase activity
TthAA11_08330	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA11_08350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA11_08360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA11_08370	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA11_08380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAA11_08400	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthAA11_08420	COG0167	dihydroorotate dehydrogenase activity
TthAA11_08500	COG0730	response to heat
TthAA11_08510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthAA11_08550	COG1960	acyl-CoA dehydrogenase activity
TthAA11_08560	COG0456	acetyltransferase
TthAA11_08580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthAA11_08590	COG0009	L-threonylcarbamoyladenylate synthase
TthAA11_08600	COG1459	type II secretion system
TthAA11_08630	COG0277	FAD linked oxidase domain protein
TthAA11_08650	COG0287	Prephenate dehydrogenase
TthAA11_08660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA11_08670	COG2514	catechol 2,3-dioxygenase activity
TthAA11_08680	COG2353	YceI-like domain
TthAA11_08690	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA11_08700	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA11_08740	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA11_08750	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthAA11_08770	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthAA11_08780	COG0151	Belongs to the GarS family
TthAA11_08790	COG5002	protein histidine kinase activity
TthAA11_08790	COG2176	DNA-directed DNA polymerase activity
TthAA11_08850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthAA11_08870	COG0217	transcriptional regulatory protein
TthAA11_08880	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthAA11_08880	COG4651	solute:proton antiporter activity
TthAA11_08890	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthAA11_08900	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthAA11_08910	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA11_08920	COG1674	ftsk spoiiie
TthAA11_08950	COG0517	IMP dehydrogenase activity
TthAA11_08990	COG0617	tRNA 3'-terminal CCA addition
TthAA11_08990	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA11_08990	COG3620	sequence-specific DNA binding
TthAA11_09010	COG1994	Peptidase M50
TthAA11_09020	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthAA11_09040	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA11_09070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA11_09080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA11_09090	COG2719	SpoVR family
TthAA11_09100	COG2718	Belongs to the UPF0229 family
TthAA11_09110	COG2766	serine protein kinase
TthAA11_09180	COG2137	regulation of response to DNA damage stimulus
TthAA11_09200	COG2359	stage V sporulation protein S
TthAA11_09210	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA11_09220	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthAA11_09240	COG0463	Glycosyl transferase, family 2
TthAA11_09250	COG0750	zinc metalloprotease
TthAA11_09260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthAA11_09270	COG0575	Belongs to the CDS family
TthAA11_09280	COG0233	cytoplasmic translational termination
TthAA11_09290	COG0528	UMP kinase activity
TthAA11_09300	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthAA11_09310	COG0052	Belongs to the universal ribosomal protein uS2 family
TthAA11_09320	COG0582	viral genome integration into host DNA
TthAA11_09410	COG1598	PFAM Uncharacterised protein family UPF0150
TthAA11_09490	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthAA11_09500	COG0494	nUDIX hydrolase
TthAA11_09560	COG0402	S-adenosylhomocysteine deaminase activity
TthAA11_09580	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA11_09590	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthAA11_09600	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA11_09610	COG1811	Na channel or pump
TthAA11_09620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA11_09620	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthAA11_09650	COG1215	transferase activity, transferring glycosyl groups
TthAA11_09670	COG1215	transferase activity, transferring glycosyl groups
TthAA11_09690	COG0438	transferase activity, transferring glycosyl groups
TthAA11_09700	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthAA11_09740	COG1024	Enoyl-CoA hydratase
TthAA11_09740	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA11_09750	COG0183	Belongs to the thiolase family
TthAA11_09760	COG1960	acyl-CoA dehydrogenase activity
TthAA11_09770	COG0215	cysteine-tRNA ligase activity
TthAA11_09780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthAA11_09840	COG1196	nuclear chromosome segregation
TthAA11_09870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthAA11_09880	COG3153	acetyltransferase
TthAA11_09880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA11_09890	COG1268	BioY protein
TthAA11_09910	COG0126	phosphoglycerate kinase activity
TthAA11_09920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthAA11_09930	COG0824	Thioesterase
TthAA11_09950	COG0557	exoribonuclease II activity
TthAA11_09960	COG1355	regulation of microtubule-based process
TthAA11_09970	COG0617	tRNA 3'-terminal CCA addition
TthAA11_09970	COG1353	crispr-associated protein
TthAA11_09980	COG0237	dephospho-CoA kinase activity
TthAA11_10000	COG0742	ribosomal rna small subunit methyltransferase
TthAA11_10010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthAA11_10020	COG0138	bifunctional purine biosynthesis protein purh
TthAA11_10030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthAA11_10050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthAA11_10220	COG0149	triose-phosphate isomerase activity
TthAA11_10230	COG3239	Fatty acid desaturase
TthAA11_10260	COG1490	D-aminoacyl-tRNA deacylase activity
TthAA11_10270	COG1307	EDD domain protein, DegV family
TthAA11_10280	COG1307	EDD domain protein, DegV family
TthAA11_10290	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthAA11_10300	COG1510	regulation of RNA biosynthetic process
TthAA11_10340	COG1136	(ABC) transporter
TthAA11_10370	COG3769	mannosylglycerate metabolic process
TthAA11_10390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthAA11_10410	COG1012	belongs to the aldehyde dehydrogenase family
TthAA11_10420	COG2368	4-hydroxyphenylacetate
TthAA11_10430	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthAA11_10490	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA11_10500	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA11_10520	COG1012	belongs to the aldehyde dehydrogenase family
TthAA11_10520	COG2030	dehydratase
TthAA11_10560	COG3396	Phenylacetate-CoA oxygenase
TthAA11_10580	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthAA11_10600	COG0395	ABC-type sugar transport system, permease component
TthAA11_10640	COG1980	fructose-bisphosphate aldolase activity
TthAA11_10650	COG1733	regulation of RNA biosynthetic process
TthAA11_10660	COG2193	ferroxidase activity
TthAA11_10670	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthAA11_10680	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthAA11_10700	COG1331	Highly conserved protein containing a thioredoxin domain
TthAA11_10710	COG0183	Belongs to the thiolase family
TthAA11_10720	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthAA11_10730	COG0477	Major facilitator Superfamily
TthAA11_10740	COG1846	Transcriptional regulator
TthAA11_10810	COG1012	belongs to the aldehyde dehydrogenase family
TthAA11_10830	COG0248	Ppx GppA phosphatase
TthAA11_10840	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthAA11_10850	COG0210	DNA helicase
TthAA11_10880	COG1309	transcriptional regulator
TthAA11_10890	COG1131	(ABC) transporter
TthAA11_10910	COG3335	DDE superfamily endonuclease
TthAA11_10950	COG0842	Transport permease protein
TthAA11_11020	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA11_11070	COG0582	viral genome integration into host DNA
TthAA11_11100	COG2897	thiosulfate sulfurtransferase activity
TthAA11_11110	COG1760	l-serine dehydratase
TthAA11_11130	COG0335	large ribosomal subunit rRNA binding
TthAA11_11140	COG0336	Belongs to the RNA methyltransferase TrmD family
TthAA11_11150	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthAA11_11160	COG1837	Belongs to the UPF0109 family
TthAA11_11170	COG0228	four-way junction DNA binding
TthAA11_11200	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA11_11210	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA11_11210	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA11_11220	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthAA11_11240	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthAA11_11260	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthAA11_11270	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthAA11_11280	COG1702	phosphate starvation-inducible protein PhoH
TthAA11_11300	COG4864	UPF0365 protein
TthAA11_11320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthAA11_11340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA11_11340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA11_11350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA11_11370	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthAA11_11380	COG1397	ADP-ribosylglycohydrolase
TthAA11_11390	COG2239	Acts as a magnesium transporter
TthAA11_11400	COG2304	oxidoreductase activity
TthAA11_11410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA11_11410	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA11_11430	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA11_11430	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA11_11440	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthAA11_11450	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthAA11_11460	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthAA11_11470	COG0006	proline dipeptidase activity
TthAA11_11490	COG0739	heme binding
TthAA11_11510	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthAA11_11520	COG0254	rRNA binding
TthAA11_11540	COG2001	Belongs to the MraZ family
TthAA11_11550	COG0275	rRNA processing
TthAA11_11580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthAA11_11600	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA11_11610	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthAA11_11620	COG0772	Belongs to the SEDS family
TthAA11_11630	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthAA11_11640	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthAA11_11650	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthAA11_11690	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthAA11_11720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA11_11740	COG0159	tryptophan synthase activity
TthAA11_11750	COG0133	tryptophan synthase activity
TthAA11_11760	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthAA11_11770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA11_11780	COG1744	ABC transporter substrate-binding protein PnrA-like
TthAA11_11790	COG3845	ABC transporter
TthAA11_11890	COG0438	transferase activity, transferring glycosyl groups
TthAA11_11900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA11_11920	COG0039	L-malate dehydrogenase activity
TthAA11_11930	COG2819	hydrolase of the alpha beta superfamily
TthAA11_11940	COG0861	Integral membrane protein TerC family
TthAA11_11960	COG0247	lactate metabolic process
TthAA11_11960	COG2181	nitrate reductase activity
TthAA11_11980	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthAA11_11990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthAA11_12000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthAA11_12020	COG0439	Biotin carboxylase
TthAA11_12030	COG0511	ligase activity, forming carbon-carbon bonds
TthAA11_12040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthAA11_12080	COG0010	Belongs to the arginase family
TthAA11_12110	COG1100	Small GTP-binding protein
TthAA11_12130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAA11_12140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA11_12160	COG2814	Major facilitator Superfamily
TthAA11_12170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthAA11_12180	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA11_12190	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthAA11_12200	COG0589	response to stress
TthAA11_12230	COG3335	DDE superfamily endonuclease
TthAA11_12250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA11_12250	COG0617	tRNA 3'-terminal CCA addition
TthAA11_12250	COG0517	IMP dehydrogenase activity
TthAA11_12260	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthAA11_12270	COG0745	RESPONSE REGULATOR receiver
TthAA11_12280	COG5002	protein histidine kinase activity
TthAA11_12290	COG1960	acyl-CoA dehydrogenase activity
TthAA11_12300	COG2086	electron transfer activity
TthAA11_12310	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthAA11_12330	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA11_12340	COG1573	uracil-dna glycosylase
TthAA11_12350	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA11_12350	COG1796	DNA polymerase
TthAA11_12380	COG2309	aminopeptidase activity
TthAA11_12400	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA11_12420	COG1011	Hydrolase
TthAA11_12460	COG2873	o-acetylhomoserine
TthAA11_12470	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA11_12490	COG1126	abc transporter atp-binding protein
TthAA11_12520	COG0134	indole-3-glycerol-phosphate synthase activity
TthAA11_12530	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthAA11_12550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthAA11_12580	COG0765	amino acid transport
TthAA11_12590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthAA11_12610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthAA11_12620	COG0569	domain protein
TthAA11_12630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA11_12640	COG1426	Protein conserved in bacteria
TthAA11_12650	COG2313	pseudouridylate synthase activity
TthAA11_12670	COG3001	Fructosamine kinase
TthAA11_12680	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA11_12700	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthAA11_12740	COG0012	GTP binding
TthAA11_12750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthAA11_12770	COG0424	maF-like protein
TthAA11_12800	COG0768	penicillin binding
TthAA11_12820	COG0850	regulation of cytokinetic process
TthAA11_12830	COG2322	membrane
TthAA11_12870	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthAA11_12880	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA11_12900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthAA11_12940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA11_12960	COG1131	(ABC) transporter
TthAA11_12990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAA11_13020	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthAA11_13030	COG0440	acetolactate synthase activity
TthAA11_13040	COG0028	Belongs to the TPP enzyme family
TthAA11_13070	COG4970	Tfp pilus assembly protein FimT
TthAA11_13080	COG4970	Tfp pilus assembly protein FimT
TthAA11_13090	COG2165	general secretion pathway protein
TthAA11_13100	COG4966	pilus assembly protein PilW
TthAA11_13120	COG2165	general secretion pathway protein
TthAA11_13140	COG4636	protein conserved in cyanobacteria
TthAA11_13190	COG0180	Tryptophanyl-tRNA synthetase
TthAA11_13200	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA11_13210	COG0066	3-isopropylmalate dehydratase activity
TthAA11_13220	COG0473	3-isopropylmalate dehydrogenase activity
TthAA11_13250	COG0300	oxidoreductase activity
TthAA11_13260	COG0129	dihydroxy-acid dehydratase activity
TthAA11_13280	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthAA11_13290	COG1177	transmembrane transport
TthAA11_13300	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthAA11_13310	COG3842	ATPase activity
TthAA11_13320	COG0772	Belongs to the SEDS family
TthAA11_13330	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthAA11_13340	COG2894	cell division
TthAA11_13350	COG1733	regulation of RNA biosynthetic process
TthAA11_13370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA11_13370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA11_13390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA11_13400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA11_13410	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA11_13420	COG0653	protein targeting
TthAA11_13430	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthAA11_13470	COG0393	Putative heavy-metal-binding
TthAA11_13480	COG1111	helicase
TthAA11_13480	COG1205	dead DEAH box helicase
TthAA11_13510	COG0358	DNA primase activity
TthAA11_13540	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA11_13550	COG0697	spore germination
TthAA11_13560	COG0612	Peptidase, M16
TthAA11_13570	COG0612	Peptidase, M16
TthAA11_13580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthAA11_13610	COG1394	ATPase activity, coupled to movement of substances
TthAA11_13620	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthAA11_13630	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthAA11_13640	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA11_13650	COG1527	subunit (C
TthAA11_13660	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA11_13680	COG1269	ATP hydrolysis coupled proton transport
TthAA11_13730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA11_13750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA11_13780	COG0419	ATPase involved in DNA repair
TthAA11_13790	COG0420	3'-5' exonuclease activity
TthAA11_13830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthAA11_13840	COG2884	Cell division ATP-binding protein ftsE
TthAA11_13850	COG0793	Belongs to the peptidase S41A family
TthAA11_13860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA11_13860	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA11_13870	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthAA11_13880	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAA11_13900	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAA11_13910	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAA11_13920	COG1129	ABC transporter
TthAA11_13930	COG0746	molybdenum cofactor guanylyltransferase activity
TthAA11_13950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA11_13990	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthAA11_14000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA11_14010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthAA11_14040	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA11_14060	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA11_14090	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA11_14100	COG0788	formyltetrahydrofolate deformylase activity
TthAA11_14110	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthAA11_14120	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthAA11_14130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthAA11_14170	COG0737	Belongs to the 5'-nucleotidase family
TthAA11_14180	COG0174	glutamine synthetase
TthAA11_14200	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA11_14240	COG0747	negative chemotaxis
TthAA11_14250	COG0601	transmembrane transport
TthAA11_14260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA11_14280	COG0285	dihydrofolate synthase activity
TthAA11_14290	COG1132	(ABC) transporter
TthAA11_14300	COG1132	(ABC) transporter
TthAA11_14310	COG0372	Belongs to the citrate synthase family
TthAA11_14320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthAA11_14330	COG1482	cell wall glycoprotein biosynthetic process
TthAA11_14350	COG1515	deoxyribonuclease V activity
TthAA11_14370	COG0776	regulation of translation
TthAA11_14400	COG2197	response regulator
TthAA11_14410	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthAA11_14420	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthAA11_14430	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthAA11_14440	COG1324	tolerance protein
TthAA11_14450	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA11_14490	COG2205	protein histidine kinase activity
TthAA11_14510	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthAA11_14520	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthAA11_14570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TthAA11_14580	COG0247	lactate metabolic process
TthAA11_14590	COG1139	Iron-sulfur cluster binding protein
TthAA11_14600	COG1556	Lactate utilization protein
TthAA11_14620	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthAA11_14630	COG0515	serine threonine protein kinase
TthAA11_14630	COG2815	serine threonine protein kinase
TthAA11_14640	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthAA11_14660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthAA11_14730	COG0473	3-isopropylmalate dehydrogenase activity
TthAA11_14780	COG1450	Type ii and iii secretion system protein
TthAA11_14790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthAA11_14800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthAA11_14810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthAA11_14820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA11_14820	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthAA11_14830	COG0736	holo-[acyl-carrier-protein] synthase activity
TthAA11_14860	COG1160	GTP binding
TthAA11_14870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthAA11_14880	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthAA11_14880	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthAA11_14890	COG2814	Major facilitator Superfamily
TthAA11_14900	COG0083	homoserine kinase activity
TthAA11_14920	COG0268	Binds directly to 16S ribosomal RNA
TthAA11_14940	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthAA11_14950	COG3335	DDE superfamily endonuclease
TthAA11_14970	COG0723	plastoquinol--plastocyanin reductase activity
TthAA11_14990	COG3088	subunit of a heme lyase
TthAA11_14990	COG4235	cytochrome complex assembly
TthAA11_15000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA11_15010	COG1138	Cytochrome C-type biogenesis protein
TthAA11_15020	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthAA11_15030	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA11_15040	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA11_15050	COG4133	protoheme IX ABC transporter activity
TthAA11_15060	COG0785	Cytochrome C biogenesis protein
TthAA11_15130	COG3258	Cytochrome c
TthAA11_15150	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA11_15180	COG3258	Cytochrome c
TthAA11_15190	COG2010	Cytochrome c
TthAA11_15200	COG0737	Belongs to the 5'-nucleotidase family
TthAA11_15210	COG2010	Cytochrome c
TthAA11_15220	COG3258	Cytochrome c
TthAA11_15260	COG2010	Cytochrome c
TthAA11_15270	COG3842	ATPase activity
TthAA11_15330	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA11_15340	COG3360	Dodecin
TthAA11_15380	COG1024	Enoyl-CoA hydratase
TthAA11_15390	COG0813	purine-nucleoside phosphorylase activity
TthAA11_15400	COG1136	(ABC) transporter
TthAA11_15410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA11_15420	COG2045	Belongs to the ComB family
TthAA11_15440	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthAA11_15460	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthAA11_15480	COG0107	imidazoleglycerol-phosphate synthase activity
TthAA11_15490	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthAA11_15490	COG0140	phosphoribosyl-ATP diphosphatase activity
TthAA11_15500	COG1494	fructose-1,6-bisphosphatase
TthAA11_15510	COG0686	Belongs to the AlaDH PNT family
TthAA11_15520	COG0427	acetyl-CoA hydrolase
TthAA11_15530	COG0084	hydrolase, TatD family'
TthAA11_15540	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthAA11_15560	COG0017	Asparaginyl-tRNA synthetase
TthAA11_15580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA11_15610	COG2009	succinate dehydrogenase
TthAA11_15620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA11_15680	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA11_15690	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthAA11_15700	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthAA11_15710	COG0504	CTP synthase activity
TthAA11_15730	COG0069	glutamate synthase activity
TthAA11_15730	COG0067	glutamate synthase
TthAA11_15730	COG0070	glutamate synthase
TthAA11_15850	COG0840	transmembrane signaling receptor activity
TthAA11_15860	COG0305	Participates in initiation and elongation during chromosome replication
TthAA11_15880	COG0475	glutathione-regulated potassium exporter activity
TthAA11_15890	COG0517	IMP dehydrogenase activity
TthAA11_15890	COG0617	tRNA 3'-terminal CCA addition
TthAA11_15890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA11_15920	COG0475	glutathione-regulated potassium exporter activity
TthAA11_15930	COG0490	domain, Protein
TthAA11_15970	COG3118	belongs to the thioredoxin family
TthAA11_16050	COG0542	response to heat
TthAA11_16070	COG0789	Transcriptional regulator
TthAA11_16080	COG0484	heat shock protein binding
TthAA11_16090	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthAA11_16100	COG0443	Heat shock 70 kDa protein
TthAA11_16110	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthAA11_16120	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthAA11_16130	COG0616	signal peptide processing
TthAA11_16160	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthAA11_16170	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA11_16180	COG0714	Associated with various cellular activities
TthAA11_16190	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAA11_16190	COG0574	Belongs to the PEP-utilizing enzyme family
TthAA11_16200	COG1272	protein, Hemolysin III
TthAA11_16220	COG5002	protein histidine kinase activity
TthAA11_16220	COG3850	Histidine kinase
TthAA11_16270	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthAA11_16300	COG1011	Hydrolase
TthAA11_16330	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthAA11_16360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthAA11_16380	COG0047	phosphoribosylformylglycinamidine synthase activity
TthAA11_16400	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthAA11_16410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthAA11_16420	COG0116	Belongs to the methyltransferase superfamily
TthAA11_16450	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthAA11_16460	COG0497	DNA recombination
TthAA11_16480	COG0604	alcohol dehydrogenase
TthAA11_16520	COG0585	pseudouridine synthase activity
TthAA11_16570	COG1595	DNA-templated transcription, initiation
TthAA11_16580	COG0557	exoribonuclease II activity
TthAA11_16590	COG0538	isocitrate dehydrogenase activity
TthAA11_16600	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA11_16600	COG2022	thiamine diphosphate biosynthetic process
TthAA11_16610	COG0590	tRNA wobble adenosine to inosine editing
TthAA11_16610	COG0037	tRNA processing
TthAA11_16650	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA11_16670	COG0322	excinuclease ABC activity
TthAA11_16680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA11_16690	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA11_16700	COG1854	S-ribosylhomocysteine lyase activity
TthAA11_16730	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAA11_16730	COG0519	Catalyzes the synthesis of GMP from XMP
TthAA11_16740	COG4636	protein conserved in cyanobacteria
TthAA11_16750	COG4274	PFAM GYD family protein
TthAA11_16760	COG0346	lactoylglutathione lyase activity
TthAA11_16770	COG0328	RNA-DNA hybrid ribonuclease activity
TthAA11_16780	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA11_16790	COG2095	MarC family integral membrane protein
TthAA11_16800	COG1438	arginine binding
TthAA11_16810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthAA11_16820	COG1758	RNA polymerase activity
TthAA11_16830	COG0194	GDP metabolic process
TthAA11_16850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthAA11_16860	COG2385	sporulation resulting in formation of a cellular spore
TthAA11_16870	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthAA11_16890	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA11_16970	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA11_16980	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA11_16990	COG1012	belongs to the aldehyde dehydrogenase family
TthAA11_17000	COG0506	proline dehydrogenase activity
TthAA11_17030	COG0156	8-amino-7-oxononanoate synthase activity
TthAA11_17040	COG0732	type I restriction modification DNA specificity domain
TthAA11_17040	COG0827	DNA restriction-modification system
TthAA11_17060	COG0187	DNA topoisomerase II activity
TthAA11_17070	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthAA11_17080	COG0193	aminoacyl-tRNA hydrolase activity
TthAA11_17090	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthAA11_17140	COG2815	serine threonine protein kinase
TthAA11_17140	COG0515	serine threonine protein kinase
TthAA11_17150	COG0631	protein serine/threonine phosphatase activity
TthAA11_17170	COG2814	Major facilitator Superfamily
TthAA11_17180	COG0113	porphobilinogen synthase activity
TthAA11_17190	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthAA11_17200	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthAA11_17250	COG0823	Involved in the tonB-independent uptake of proteins
TthAA11_17250	COG1506	peptidase
TthAA11_17250	COG4946	Tricorn protease homolog
TthAA11_17260	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthAA11_17270	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthAA11_17310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthAA11_17320	COG1011	Hydrolase
TthAA11_17370	COG0537	adenosine 5'-monophosphoramidase activity
TthAA11_17380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA11_17390	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthAA11_17400	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthAA11_17410	COG0071	Belongs to the small heat shock protein (HSP20) family
TthAA11_17420	COG2897	thiosulfate sulfurtransferase activity
TthAA11_17430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA11_17450	COG1764	response to oxidative stress
TthAA11_17500	COG3842	ATPase activity
TthAA11_17510	COG0101	tRNA pseudouridine synthase activity
TthAA11_17520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA11_17530	COG0601	transmembrane transport
TthAA11_17590	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA11_17620	COG1166	arginine decarboxylase activity
TthAA11_17640	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthAA11_17650	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthAA11_17660	COG1611	Belongs to the LOG family
TthAA11_17670	COG1193	negative regulation of DNA recombination
TthAA11_17680	COG0366	Alpha amylase catalytic
TthAA11_17750	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthAA11_17760	COG0142	geranyltranstransferase activity
TthAA11_17780	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthAA11_17840	COG0203	ribosomal protein L17
TthAA11_17850	COG0202	RNA polymerase activity
TthAA11_17860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthAA11_17870	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthAA11_17880	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthAA11_17890	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthAA11_17910	COG0563	adenylate kinase activity
TthAA11_17920	COG0201	protein transport
TthAA11_17970	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthAA11_17980	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthAA11_17990	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthAA11_18040	COG0255	Belongs to the universal ribosomal protein uL29 family
TthAA11_18050	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthAA11_18060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthAA11_18080	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthAA11_18090	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthAA11_18100	COG0089	rRNA binding
TthAA11_18110	COG0088	Forms part of the polypeptide exit tunnel
TthAA11_18130	COG0051	transcription antitermination factor activity, RNA binding
TthAA11_18140	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA11_18150	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA11_18160	COG0049	tRNA binding
TthAA11_18190	COG0442	prolyl-tRNA aminoacylation
TthAA11_18210	COG1115	amino acid carrier protein
TthAA11_18250	COG1489	DNA binding
TthAA11_18280	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthAA11_18320	COG0432	Pfam Uncharacterised protein family UPF0047
TthAA11_18330	COG3253	May function as heme-dependent peroxidase
TthAA11_18340	COG0668	transmembrane transport
TthAA11_18360	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthAA11_18370	COG2217	Heavy metal translocating P-type atpase
TthAA11_18410	COG0745	RESPONSE REGULATOR receiver
TthAA11_18420	COG2205	protein histidine kinase activity
TthAA11_18450	COG2226	methyltransferase
TthAA11_18490	COG2132	Multicopper oxidase
TthAA11_18510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthAA11_18520	COG0822	iron-sulfur transferase activity
TthAA11_18560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthAA11_18580	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthAA11_18590	COG0284	orotidine-5'-phosphate decarboxylase activity
TthAA11_18610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA11_18630	COG0416	fatty acid biosynthetic process
TthAA11_18640	COG3118	belongs to the thioredoxin family
TthAA11_18650	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA11_18660	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthAA11_18680	COG0438	transferase activity, transferring glycosyl groups
TthAA11_18710	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthAA11_18720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA11_18730	COG3706	GGDEF domain
TthAA11_18800	COG0437	4 iron, 4 sulfur cluster binding
TthAA11_18830	COG0825	malonyl-CoA metabolic process
TthAA11_18840	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthAA11_18910	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthAA11_18960	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthAA11_18970	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthAA11_18980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthAA11_18990	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthAA11_19010	COG4974	Belongs to the 'phage' integrase family
TthAA11_19190	COG0315	cyclic pyranopterin monophosphate synthase activity
TthAA11_19200	COG2860	membrane
TthAA11_19220	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthAA11_19250	COG0477	Major facilitator Superfamily
TthAA11_19260	COG1694	Mazg nucleotide pyrophosphohydrolase
TthAA11_19270	COG1803	Methylglyoxal synthase
TthAA11_19290	COG0301	tRNA thio-modification
TthAA11_19300	COG0154	amidase activity
TthAA11_19310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthAA11_19340	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthAA11_19350	COG1607	acyl-coa hydrolase
TthAA11_19370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthAA11_19380	COG4149	molybdate abc transporter
TthAA11_19390	COG1840	ABC-type Fe3 transport system, periplasmic component
TthAA11_19420	COG0235	Class ii aldolase
TthAA11_19430	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthAA11_19440	COG0085	RNA polymerase activity
TthAA11_19460	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthAA11_19470	COG1077	Cell shape determining protein MreB Mrl
TthAA11_19480	COG1418	mRNA catabolic process
TthAA11_19480	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthAA11_19490	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthAA11_19500	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthAA11_19510	COG1546	Belongs to the CinA family
TthAA11_19510	COG1058	Belongs to the CinA family
TthAA11_19520	COG0354	folic acid binding
TthAA11_19550	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA11_19580	COG1175	transmembrane transport
TthAA11_19600	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthAA11_19620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA11_19640	COG1136	(ABC) transporter
TthAA11_19640	COG0577	efflux transmembrane transporter activity
TthAA11_19650	COG4181	ATPase activity
TthAA11_19660	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA11_19690	COG0396	ATPase activity
TthAA11_19700	COG0719	Fe-S assembly protein
TthAA11_19710	COG0719	Fe-S assembly protein
TthAA11_19720	COG2146	nitrite reductase [NAD(P)H] activity
TthAA11_19740	COG0512	Glutamine amidotransferase of anthranilate synthase
TthAA11_19750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA11_19820	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA11_19830	COG2226	methyltransferase
TthAA11_19840	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAA11_19850	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAA11_19880	COG1774	PSP1 C-terminal conserved region
TthAA11_19890	COG0470	DNA polymerase III
TthAA11_19960	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthAA11_19970	COG0302	gtp cyclohydrolase
TthAA11_20020	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthAA11_20040	COG0395	ABC-type sugar transport system, permease component
TthAA11_20050	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthAA11_20060	COG1131	(ABC) transporter
TthAA11_20100	COG0556	nucleotide-excision repair
TthAA11_20110	COG0497	DNA recombination
TthAA11_20120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthAA11_20130	COG0445	tRNA wobble uridine modification
TthAA11_20170	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA11_20170	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthAA11_20180	COG1543	Belongs to the glycosyl hydrolase 57 family
TthAA11_20190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA11_20200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA11_20210	COG0189	ligase activity
TthAA11_20240	COG0066	3-isopropylmalate dehydratase activity
TthAA11_20250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA11_20280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAA11_20290	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthAA11_20300	COG1960	acyl-CoA dehydrogenase activity
TthAA11_20310	COG0163	prenyltransferase activity
TthAA11_20380	COG2096	Adenosyltransferase
TthAA11_20410	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthAA11_20420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthAA11_20440	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthAA11_20450	COG0723	plastoquinol--plastocyanin reductase activity
TthAA11_20500	COG1653	transport
TthAA11_20510	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthAA11_20520	COG1960	acyl-CoA dehydrogenase activity
TthAA11_20540	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthAA11_20610	COG1131	(ABC) transporter
TthAA11_20660	COG3956	TIGRFAM MazG family protein
TthAA11_20680	COG0693	protein deglycase activity
TthAA11_20690	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA11_20710	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthAA11_20720	COG1937	Protein conserved in bacteria
TthAA11_20740	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthAA11_20740	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthAA11_20750	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthAA11_20760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA11_20800	COG0205	6-phosphofructokinase activity
TthAA11_20810	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthAA11_20830	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthAA11_20860	COG0658	competence protein
TthAA11_20860	COG2333	competence protein COMEC
TthAA11_20870	COG1475	DNA binding
TthAA11_20880	COG1192	Involved in chromosome partitioning
TthAA11_20890	COG0357	Ribosomal RNA small subunit methyltransferase G
TthAA11_20900	COG0445	tRNA wobble uridine modification
TthAA11_20910	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TthAA11_20920	COG1785	Belongs to the alkaline phosphatase family
TthAA11_20930	COG1492	cobalamin metabolic process
TthAA11_21000	COG0778	Nitroreductase
TthAA11_21010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA11_21010	COG1648	precorrin-2 dehydrogenase activity
TthAA11_21100	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthAA11_21110	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthAA11_21120	COG0588	phosphoglycerate mutase activity
TthAA11_21150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthAA11_21170	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TthAA11_21180	COG1797	cobyrinic acid a,c-diamide synthase activity
TthAA11_21450	COG1063	alcohol dehydrogenase
TthAA11_21480	COG3181	Tripartite tricarboxylate transporter family receptor
TthAA11_21580	COG2084	Dehydrogenase
TthAA11_21600	COG1942	4-Oxalocrotonate Tautomerase
TthAA11_21740	COG3850	Histidine kinase
TthAA11_21740	COG5002	protein histidine kinase activity
TthAA11_21750	COG0745	RESPONSE REGULATOR receiver
TthAA11_21850	COG0863	Belongs to the N(4) N(6)-methyltransferase family
TthAA11_21920	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthAA11_22060	COG2329	Antibiotic biosynthesis monooxygenase
TthAA11_22100	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA11_22120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA11_22130	COG0642	Histidine kinase
TthAA11_22140	COG0745	RESPONSE REGULATOR receiver
TthAA11_22150	COG0745	RESPONSE REGULATOR receiver
TthAA11_22160	COG0671	phosphoesterase, PA-phosphatase related
TthAA11_22220	COG0730	response to heat
TthAA11_22250	COG0363	glucosamine-6-phosphate deaminase activity
TthAA11_22260	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TthAA11_22270	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TthAA11_22360	COG2010	Cytochrome c
TthAA11_22370	COG0745	RESPONSE REGULATOR receiver
TthAA11_22380	COG2205	protein histidine kinase activity
TthAA11_22440	COG3335	DDE superfamily endonuclease
TthAA11_22450	COG0513	Belongs to the DEAD box helicase family
TthAA11_22480	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthAA11_22490	COG1475	DNA binding
TthAA11_22520	COG0514	ATP-dependent DNA helicase (RecQ)
TthAA11_22530	COG1475	DNA binding
TthAA11_22570	COG1402	creatininase
TthAA11_22580	COG1802	Transcriptional regulator
TthAA11_22590	COG1063	alcohol dehydrogenase
TthAA11_22630	COG2181	nitrate reductase activity
TthAA11_22650	COG1140	nitrate reductase beta subunit
TthAA11_22660	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TthAA11_22670	COG2010	Cytochrome c
TthAA11_22690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA11_22710	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TthAA11_22760	COG1252	NADH dehydrogenase
TthAA11_22770	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA11_22790	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA11_22910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthAA11_22950	COG2010	Cytochrome c
TthAA11_22960	COG0535	radical SAM domain protein
TthAA11_22990	COG3256	nitric oxide reductase
TthAA11_23090	COG1192	Involved in chromosome partitioning
TthAA11_23100	COG1475	DNA binding
TthAA11_23120	COG1475	DNA binding
TthAA11_23180	COG3345	alpha-galactosidase
TthAA11_23190	COG1085	galactose-1-phosphate uridylyltransferase
TthAA11_23250	COG1304	FMN binding
TthAA11_23270	COG1487	ribonuclease activity
TthAA11_23320	COG2124	cytochrome p450
TthAA11_23340	COG1562	ergosterol biosynthetic process
TthAA11_23360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA11_23390	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA11_23420	COG1175	transmembrane transport
TthAA11_23450	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA11_23460	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA11_23480	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthAA11_23490	COG0800	Aldolase
TthAA11_23580	COG4974	Belongs to the 'phage' integrase family
TthAA11_t00340	COG0544	peptidyl-prolyl cis-trans isomerase activity