locus-tag	class	description
TthAA22_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthAA22_00020	COG0592	DNA-directed DNA polymerase activity
TthAA22_00030	COG0148	phosphopyruvate hydratase activity
TthAA22_00040	COG0469	pyruvate kinase activity
TthAA22_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA22_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthAA22_00090	COG1842	Phage shock protein A
TthAA22_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthAA22_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA22_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthAA22_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthAA22_00180	COG1496	oxidoreductase activity
TthAA22_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA22_00200	COG1278	Cold shock
TthAA22_00230	COG1653	transport
TthAA22_00260	COG0033	Phosphoglucomutase
TthAA22_00300	COG0517	IMP dehydrogenase activity
TthAA22_00300	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthAA22_00310	COG1950	PFAM Membrane protein of
TthAA22_00320	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthAA22_00330	COG1047	Peptidyl-prolyl cis-trans
TthAA22_00340	COG0181	hydroxymethylbilane synthase activity
TthAA22_00360	COG0285	dihydrofolate synthase activity
TthAA22_00370	COG0436	Aminotransferase
TthAA22_00380	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthAA22_00430	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthAA22_00440	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthAA22_00450	COG1993	acr, cog1993
TthAA22_00460	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthAA22_00480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA22_00500	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthAA22_00510	COG1335	isochorismatase
TthAA22_00520	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthAA22_00550	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthAA22_00560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthAA22_00600	COG1660	Displays ATPase and GTPase activities
TthAA22_00610	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthAA22_00720	COG3335	DDE superfamily endonuclease
TthAA22_00740	COG1845	cytochrome c oxidase, subunit III
TthAA22_00740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA22_00750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAA22_00750	COG2010	Cytochrome c
TthAA22_00760	COG0109	protoheme IX farnesyltransferase activity
TthAA22_00760	COG1612	heme a metabolic process
TthAA22_00790	COG0343	queuine tRNA-ribosyltransferase activity
TthAA22_00800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthAA22_00810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthAA22_00920	COG1940	carbohydrate kinase activity
TthAA22_00940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA22_00950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA22_00960	COG0589	response to stress
TthAA22_00970	COG1611	Belongs to the LOG family
TthAA22_00990	COG1011	Hydrolase
TthAA22_01000	COG0632	four-way junction helicase activity
TthAA22_01010	COG1024	Enoyl-CoA hydratase
TthAA22_01030	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA22_01050	COG0137	argininosuccinate synthase activity
TthAA22_01060	COG0165	Argininosuccinate lyase
TthAA22_01100	COG0505	Belongs to the CarA family
TthAA22_01120	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthAA22_01130	COG0166	Belongs to the GPI family
TthAA22_01160	COG0714	Associated with various cellular activities
TthAA22_01190	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA22_01200	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthAA22_01210	COG0459	protein refolding
TthAA22_01220	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthAA22_01230	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthAA22_01250	COG0778	Nitroreductase
TthAA22_01260	COG0791	NLP P60 protein
TthAA22_01260	COG1388	LysM domain
TthAA22_01280	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthAA22_01300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthAA22_01310	COG0581	inorganic phosphate transmembrane transporter activity
TthAA22_01320	COG0573	inorganic phosphate transmembrane transporter activity
TthAA22_01340	COG0482	sulfurtransferase activity
TthAA22_01360	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthAA22_01370	COG0735	belongs to the Fur family
TthAA22_01400	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthAA22_01410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA22_01420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthAA22_01430	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthAA22_01440	COG0250	Participates in transcription elongation, termination and antitermination
TthAA22_01460	COG0081	regulation of translation
TthAA22_01480	COG0629	single-stranded DNA binding
TthAA22_01490	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthAA22_01500	COG0359	binds to the 23S rRNA
TthAA22_01540	COG0300	oxidoreductase activity
TthAA22_01550	COG0321	lipoyl(octanoyl) transferase activity
TthAA22_01560	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthAA22_01610	COG1476	TRANSCRIPTIONal
TthAA22_01650	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthAA22_01680	COG1598	PFAM Uncharacterised protein family UPF0150
TthAA22_01690	COG0022	dehydrogenase e1 component
TthAA22_01700	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthAA22_01710	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthAA22_01760	COG2226	methyltransferase
TthAA22_01770	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthAA22_01800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthAA22_01810	COG1187	pseudouridine synthase activity
TthAA22_01830	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthAA22_01840	COG0686	Belongs to the AlaDH PNT family
TthAA22_01860	COG1461	Dihydroxyacetone kinase
TthAA22_01900	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthAA22_01910	COG0222	ribosome binding
TthAA22_01920	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthAA22_01940	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthAA22_01970	COG0697	spore germination
TthAA22_01990	COG3177	Filamentation induced by cAMP protein fic
TthAA22_02010	COG0243	molybdopterin cofactor binding
TthAA22_02020	COG2272	Belongs to the type-B carboxylesterase lipase family
TthAA22_02030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthAA22_02050	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA22_02080	COG0477	Major facilitator Superfamily
TthAA22_02110	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthAA22_02130	COG0105	UTP biosynthetic process
TthAA22_02140	COG0631	protein serine/threonine phosphatase activity
TthAA22_02150	COG0583	DNA-binding transcription factor activity
TthAA22_02170	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA22_02230	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA22_02250	COG1278	Cold shock
TthAA22_02260	COG0484	heat shock protein binding
TthAA22_02270	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthAA22_02280	COG1968	undecaprenyl-diphosphatase activity
TthAA22_02290	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthAA22_02300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthAA22_02330	COG1309	transcriptional regulator
TthAA22_02370	COG0802	atpase or kinase
TthAA22_02380	COG0539	negative regulation of cytoplasmic translation
TthAA22_02390	COG0495	leucyl-tRNA aminoacylation
TthAA22_02430	COG1902	pentaerythritol trinitrate reductase activity
TthAA22_02480	COG2414	aldehyde ferredoxin oxidoreductase
TthAA22_02500	COG2165	general secretion pathway protein
TthAA22_02520	COG2165	general secretion pathway protein
TthAA22_02580	COG1459	type II secretion system
TthAA22_02600	COG1187	pseudouridine synthase activity
TthAA22_02620	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA22_02630	COG0745	RESPONSE REGULATOR receiver
TthAA22_02640	COG4191	Histidine kinase
TthAA22_02650	COG0704	Plays a role in the regulation of phosphate uptake
TthAA22_02660	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthAA22_02680	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthAA22_02700	COG0515	serine threonine protein kinase
TthAA22_02700	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthAA22_02790	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthAA22_02800	COG4221	oxidoreductase activity
TthAA22_02830	COG0717	Belongs to the dCTP deaminase family
TthAA22_02840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthAA22_02850	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthAA22_02860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA22_02900	COG0583	DNA-binding transcription factor activity
TthAA22_02910	COG3546	catalase activity
TthAA22_02920	COG0758	DNA mediated transformation
TthAA22_02920	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA22_02930	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthAA22_02950	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA22_02970	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthAA22_02990	COG0442	prolyl-tRNA aminoacylation
TthAA22_03000	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthAA22_03040	COG0303	'Molybdopterin
TthAA22_03050	COG0513	Belongs to the DEAD box helicase family
TthAA22_03100	COG4983	Phage plasmid primase, P4 family domain protein
TthAA22_03190	COG0582	viral genome integration into host DNA
TthAA22_03200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthAA22_03220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthAA22_03280	COG2070	2-Nitropropane dioxygenase
TthAA22_03310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthAA22_03320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA22_03330	COG0018	arginyl-trna synthetase
TthAA22_03340	COG1007	ATP synthesis coupled electron transport
TthAA22_03350	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA22_03360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthAA22_03370	COG0713	ATP synthesis coupled electron transport
TthAA22_03380	COG0839	Belongs to the complex I subunit 6 family
TthAA22_03390	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA22_03400	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthAA22_03410	COG1034	ATP synthesis coupled electron transport
TthAA22_03420	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthAA22_03430	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthAA22_03440	COG0649	NAD binding
TthAA22_03450	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA22_03460	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA22_03470	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA22_03480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthAA22_03500	COG4712	double-strand break repair protein
TthAA22_03580	COG0135	phosphoribosylanthranilate isomerase activity
TthAA22_03600	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthAA22_03620	COG2720	vancomycin resistance protein
TthAA22_03640	COG1126	abc transporter atp-binding protein
TthAA22_03700	COG0277	FAD linked oxidase domain protein
TthAA22_03730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthAA22_03740	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthAA22_03770	COG0314	molybdopterin synthase activity
TthAA22_03780	COG1420	regulation of RNA biosynthetic process
TthAA22_03790	COG0347	Belongs to the P(II) protein family
TthAA22_03800	COG0004	ammonium transporteR
TthAA22_03820	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthAA22_03840	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA22_03870	COG1597	lipid kinase activity
TthAA22_03880	COG0436	Aminotransferase
TthAA22_03900	COG0475	glutathione-regulated potassium exporter activity
TthAA22_03900	COG0569	domain protein
TthAA22_03920	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthAA22_03940	COG0277	FAD linked oxidase domain protein
TthAA22_03990	COG0667	Aldo Keto reductase
TthAA22_04050	COG1067	ATP-dependent peptidase activity
TthAA22_04060	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthAA22_04080	COG0745	RESPONSE REGULATOR receiver
TthAA22_04090	COG2105	PFAM AIG2 family protein
TthAA22_04100	COG0297	glycogen (starch) synthase activity
TthAA22_04120	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthAA22_04130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthAA22_04160	COG0142	geranyltranstransferase activity
TthAA22_04180	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthAA22_04190	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_04200	COG0492	ferredoxin-NADP+ reductase activity
TthAA22_04220	COG0792	nuclease activity
TthAA22_04230	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthAA22_04260	COG1175	transmembrane transport
TthAA22_04270	COG0395	ABC-type sugar transport system, permease component
TthAA22_04330	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthAA22_04340	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthAA22_04350	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthAA22_04360	COG0805	protein transport
TthAA22_04370	COG1605	Chorismate mutase
TthAA22_04370	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA22_04490	COG1063	alcohol dehydrogenase
TthAA22_04550	COG2255	four-way junction helicase activity
TthAA22_04560	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthAA22_04570	COG0564	pseudouridine synthase activity
TthAA22_04600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthAA22_04610	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthAA22_04620	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthAA22_04630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthAA22_04650	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthAA22_04660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthAA22_04670	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthAA22_04740	COG0778	Nitroreductase
TthAA22_04770	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthAA22_04780	COG0131	Imidazoleglycerol-phosphate dehydratase
TthAA22_04790	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthAA22_04800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAA22_04810	COG0517	IMP dehydrogenase activity
TthAA22_04810	COG0516	GMP reductase activity
TthAA22_04840	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthAA22_04850	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA22_04880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA22_04920	COG0706	membrane insertase activity
TthAA22_04930	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthAA22_04940	COG0594	ribonuclease P activity
TthAA22_04960	COG1022	Amp-dependent synthetase and ligase
TthAA22_05010	COG1121	(ABC) transporter
TthAA22_05020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthAA22_05030	COG1959	2 iron, 2 sulfur cluster binding
TthAA22_05040	COG1104	cysteine desulfurase activity
TthAA22_05050	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthAA22_05060	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthAA22_05090	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_05130	COG0492	ferredoxin-NADP+ reductase activity
TthAA22_05150	COG3321	synthase
TthAA22_05150	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_05150	COG0604	alcohol dehydrogenase
TthAA22_05160	COG0747	negative chemotaxis
TthAA22_05170	COG0601	transmembrane transport
TthAA22_05180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA22_05210	COG0617	tRNA 3'-terminal CCA addition
TthAA22_05210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA22_05210	COG0517	IMP dehydrogenase activity
TthAA22_05220	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA22_05230	COG2104	thiamine diphosphate biosynthetic process
TthAA22_05240	COG0037	tRNA processing
TthAA22_05270	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthAA22_05320	COG4176	ABC-type proline glycine betaine transport system permease component
TthAA22_05330	COG4175	Glycine betaine
TthAA22_05330	COG3448	diguanylate cyclase activity
TthAA22_05340	COG0366	Alpha amylase catalytic
TthAA22_05350	COG2226	methyltransferase
TthAA22_05360	COG2226	methyltransferase
TthAA22_05370	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthAA22_05390	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthAA22_05400	COG0460	homoserine dehydrogenase
TthAA22_05420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthAA22_05490	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthAA22_05530	COG0247	lactate metabolic process
TthAA22_05540	COG0277	FAD linked oxidase domain protein
TthAA22_05550	COG0277	FAD linked oxidase domain protein
TthAA22_05560	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthAA22_05570	COG1414	Transcriptional regulator
TthAA22_05580	COG0789	Transcriptional regulator
TthAA22_05600	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA22_05610	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA22_05680	COG0861	Integral membrane protein TerC family
TthAA22_05700	COG2151	metal-sulfur cluster biosynthetic enzyme
TthAA22_05710	COG0281	malic enzyme
TthAA22_05740	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthAA22_05750	COG0509	glycine decarboxylation via glycine cleavage system
TthAA22_05760	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA22_05770	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA22_05780	COG0196	riboflavin kinase activity
TthAA22_05790	COG0494	nUDIX hydrolase
TthAA22_05830	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthAA22_05840	COG2813	Specifically methylates the guanine in position
TthAA22_05850	COG0527	aspartate kinase activity
TthAA22_05910	COG4956	integral membrane protein (PIN domain superfamily)
TthAA22_05920	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthAA22_05930	COG0542	response to heat
TthAA22_05940	COG0423	glycine-tRNA ligase activity
TthAA22_05960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthAA22_06000	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA22_06000	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA22_06020	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthAA22_06040	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthAA22_06060	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA22_06070	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA22_06080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthAA22_06090	COG0114	fumarate hydratase activity
TthAA22_06100	COG0183	Belongs to the thiolase family
TthAA22_06130	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthAA22_06140	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthAA22_06170	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthAA22_06180	COG1254	Belongs to the acylphosphatase family
TthAA22_06210	COG1063	alcohol dehydrogenase
TthAA22_06230	COG2133	pyrroloquinoline quinone binding
TthAA22_06250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthAA22_06260	COG0154	amidase activity
TthAA22_06320	COG0572	uridine kinase
TthAA22_06330	COG3842	ATPase activity
TthAA22_06360	COG4475	Protein of unknown function (DUF436)
TthAA22_06400	COG1595	DNA-templated transcription, initiation
TthAA22_06520	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA22_06530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthAA22_06540	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthAA22_06570	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthAA22_06580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthAA22_06590	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthAA22_06600	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthAA22_06620	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_06630	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA22_06640	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_06640	COG2030	dehydratase
TthAA22_06650	COG1960	acyl-CoA dehydrogenase activity
TthAA22_06680	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthAA22_06690	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthAA22_06700	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthAA22_06720	COG3870	Protein conserved in bacteria
TthAA22_06730	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthAA22_06750	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthAA22_06760	COG0740	serine-type endopeptidase activity
TthAA22_06770	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthAA22_06780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthAA22_06790	COG0646	methionine synthase
TthAA22_06790	COG1410	methionine synthase
TthAA22_06800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA22_06860	COG1692	metallophosphoesterase
TthAA22_06870	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthAA22_06910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthAA22_06920	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthAA22_07050	COG0438	transferase activity, transferring glycosyl groups
TthAA22_07110	COG0438	transferase activity, transferring glycosyl groups
TthAA22_07120	COG1215	transferase activity, transferring glycosyl groups
TthAA22_07150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA22_07190	COG0489	protein tyrosine kinase activity
TthAA22_07210	COG2264	protein methyltransferase activity
TthAA22_07220	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthAA22_07280	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAA22_07280	COG0574	Belongs to the PEP-utilizing enzyme family
TthAA22_07300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthAA22_07310	COG2046	Belongs to the sulfate adenylyltransferase family
TthAA22_07320	COG1648	precorrin-2 dehydrogenase activity
TthAA22_07320	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA22_07330	COG0730	response to heat
TthAA22_07340	COG0175	sulfate reduction
TthAA22_07350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA22_07350	COG1648	precorrin-2 dehydrogenase activity
TthAA22_07360	COG1587	Uroporphyrinogen-III synthase
TthAA22_07370	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthAA22_07390	COG0352	thiamine-phosphate diphosphorylase activity
TthAA22_07400	COG2104	thiamine diphosphate biosynthetic process
TthAA22_07410	COG2022	thiamine diphosphate biosynthetic process
TthAA22_07420	COG2022	thiamine diphosphate biosynthetic process
TthAA22_07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA22_07430	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthAA22_07440	COG0477	Major facilitator Superfamily
TthAA22_07450	COG0351	phosphomethylpyrimidine kinase
TthAA22_07450	COG0352	thiamine-phosphate diphosphorylase activity
TthAA22_07510	COG1175	transmembrane transport
TthAA22_07530	COG1940	carbohydrate kinase activity
TthAA22_07540	COG0183	Belongs to the thiolase family
TthAA22_07570	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_07610	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA22_07640	COG2030	dehydratase
TthAA22_07660	COG0596	Alpha beta hydrolase
TthAA22_07670	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA22_07700	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA22_07700	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA22_07720	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthAA22_07740	COG0195	Participates in both transcription termination and antitermination
TthAA22_07750	COG0779	Required for maturation of 30S ribosomal subunits
TthAA22_07760	COG0739	heme binding
TthAA22_07770	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthAA22_07780	COG0640	Transcriptional regulator
TthAA22_07790	COG2217	Heavy metal translocating P-type atpase
TthAA22_07820	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthAA22_07830	COG0017	Asparaginyl-tRNA synthetase
TthAA22_07840	COG0561	phosphatase activity
TthAA22_07850	COG0384	phenazine biosynthesis protein PhzF
TthAA22_07870	COG0124	histidyl-tRNA synthetase
TthAA22_07890	COG3842	ATPase activity
TthAA22_07930	COG2801	Transposase and inactivated derivatives
TthAA22_07950	COG1573	uracil-dna glycosylase
TthAA22_07990	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthAA22_08000	COG0519	Catalyzes the synthesis of GMP from XMP
TthAA22_08000	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAA22_08020	COG1316	TRANSCRIPTIONal
TthAA22_08030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthAA22_08120	COG0295	cytidine deaminase activity
TthAA22_08160	COG1760	l-serine dehydratase
TthAA22_08180	COG0481	GTPase activity
TthAA22_08200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthAA22_08210	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthAA22_08230	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_08280	COG0405	Gamma-glutamyltransferase
TthAA22_08300	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthAA22_08310	COG2873	o-acetylhomoserine
TthAA22_08340	COG1063	alcohol dehydrogenase
TthAA22_08360	COG3191	aminopeptidase activity
TthAA22_08370	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA22_08390	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA22_08400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA22_08410	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA22_08420	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAA22_08440	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthAA22_08450	COG3300	MHYT domain
TthAA22_08450	COG5001	Diguanylate cyclase
TthAA22_08470	COG0167	dihydroorotate dehydrogenase activity
TthAA22_08550	COG0730	response to heat
TthAA22_08560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthAA22_08600	COG1960	acyl-CoA dehydrogenase activity
TthAA22_08610	COG0456	acetyltransferase
TthAA22_08630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthAA22_08640	COG0009	L-threonylcarbamoyladenylate synthase
TthAA22_08650	COG1459	type II secretion system
TthAA22_08680	COG0277	FAD linked oxidase domain protein
TthAA22_08700	COG0287	Prephenate dehydrogenase
TthAA22_08710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA22_08720	COG2514	catechol 2,3-dioxygenase activity
TthAA22_08730	COG2353	YceI-like domain
TthAA22_08740	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA22_08750	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA22_08790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA22_08800	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthAA22_08820	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthAA22_08830	COG0151	Belongs to the GarS family
TthAA22_08840	COG2176	DNA-directed DNA polymerase activity
TthAA22_08840	COG5002	protein histidine kinase activity
TthAA22_08900	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthAA22_08920	COG0217	transcriptional regulatory protein
TthAA22_08930	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthAA22_08930	COG4651	solute:proton antiporter activity
TthAA22_08940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthAA22_08950	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthAA22_08960	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA22_08970	COG1674	ftsk spoiiie
TthAA22_09000	COG0517	IMP dehydrogenase activity
TthAA22_09020	COG0617	tRNA 3'-terminal CCA addition
TthAA22_09020	COG3620	sequence-specific DNA binding
TthAA22_09020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA22_09040	COG1994	Peptidase M50
TthAA22_09050	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthAA22_09070	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA22_09100	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA22_09110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA22_09120	COG2719	SpoVR family
TthAA22_09130	COG2718	Belongs to the UPF0229 family
TthAA22_09140	COG2766	serine protein kinase
TthAA22_09190	COG2137	regulation of response to DNA damage stimulus
TthAA22_09210	COG2359	stage V sporulation protein S
TthAA22_09220	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA22_09230	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthAA22_09250	COG0463	Glycosyl transferase, family 2
TthAA22_09260	COG0750	zinc metalloprotease
TthAA22_09270	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthAA22_09280	COG0575	Belongs to the CDS family
TthAA22_09290	COG0233	cytoplasmic translational termination
TthAA22_09300	COG0528	UMP kinase activity
TthAA22_09310	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthAA22_09320	COG0052	Belongs to the universal ribosomal protein uS2 family
TthAA22_09330	COG0582	viral genome integration into host DNA
TthAA22_09420	COG1598	PFAM Uncharacterised protein family UPF0150
TthAA22_09500	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthAA22_09510	COG0494	nUDIX hydrolase
TthAA22_09570	COG0402	S-adenosylhomocysteine deaminase activity
TthAA22_09590	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA22_09600	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthAA22_09610	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA22_09620	COG1811	Na channel or pump
TthAA22_09630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA22_09630	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthAA22_09660	COG1215	transferase activity, transferring glycosyl groups
TthAA22_09680	COG1215	transferase activity, transferring glycosyl groups
TthAA22_09700	COG0438	transferase activity, transferring glycosyl groups
TthAA22_09710	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthAA22_09740	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA22_09740	COG1024	Enoyl-CoA hydratase
TthAA22_09750	COG0183	Belongs to the thiolase family
TthAA22_09760	COG1960	acyl-CoA dehydrogenase activity
TthAA22_09770	COG0215	cysteine-tRNA ligase activity
TthAA22_09780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthAA22_09840	COG1196	nuclear chromosome segregation
TthAA22_09870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthAA22_09880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA22_09880	COG3153	acetyltransferase
TthAA22_09890	COG1268	BioY protein
TthAA22_09910	COG0126	phosphoglycerate kinase activity
TthAA22_09920	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthAA22_09930	COG0824	Thioesterase
TthAA22_09950	COG0557	exoribonuclease II activity
TthAA22_09960	COG1355	regulation of microtubule-based process
TthAA22_09970	COG0617	tRNA 3'-terminal CCA addition
TthAA22_09970	COG1353	crispr-associated protein
TthAA22_09980	COG0237	dephospho-CoA kinase activity
TthAA22_10000	COG0742	ribosomal rna small subunit methyltransferase
TthAA22_10010	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthAA22_10020	COG0138	bifunctional purine biosynthesis protein purh
TthAA22_10030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthAA22_10050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthAA22_10180	COG0149	triose-phosphate isomerase activity
TthAA22_10190	COG3239	Fatty acid desaturase
TthAA22_10220	COG1490	D-aminoacyl-tRNA deacylase activity
TthAA22_10230	COG1307	EDD domain protein, DegV family
TthAA22_10240	COG1307	EDD domain protein, DegV family
TthAA22_10250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthAA22_10260	COG1510	regulation of RNA biosynthetic process
TthAA22_10300	COG1136	(ABC) transporter
TthAA22_10330	COG3769	mannosylglycerate metabolic process
TthAA22_10350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthAA22_10370	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_10380	COG2368	4-hydroxyphenylacetate
TthAA22_10390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthAA22_10450	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA22_10460	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA22_10480	COG2030	dehydratase
TthAA22_10480	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_10520	COG3396	Phenylacetate-CoA oxygenase
TthAA22_10540	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthAA22_10560	COG0395	ABC-type sugar transport system, permease component
TthAA22_10600	COG1980	fructose-bisphosphate aldolase activity
TthAA22_10610	COG1733	regulation of RNA biosynthetic process
TthAA22_10620	COG2193	ferroxidase activity
TthAA22_10630	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthAA22_10640	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthAA22_10660	COG1331	Highly conserved protein containing a thioredoxin domain
TthAA22_10670	COG0183	Belongs to the thiolase family
TthAA22_10680	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthAA22_10690	COG0477	Major facilitator Superfamily
TthAA22_10700	COG1846	Transcriptional regulator
TthAA22_10780	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_10790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthAA22_10800	COG0210	DNA helicase
TthAA22_10850	COG0745	RESPONSE REGULATOR receiver
TthAA22_10860	COG2205	protein histidine kinase activity
TthAA22_10890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TthAA22_10900	COG1136	(ABC) transporter
TthAA22_10910	COG0577	efflux transmembrane transporter activity
TthAA22_10910	COG1136	(ABC) transporter
TthAA22_10990	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA22_11040	COG0582	viral genome integration into host DNA
TthAA22_11050	COG2897	thiosulfate sulfurtransferase activity
TthAA22_11060	COG1760	l-serine dehydratase
TthAA22_11070	COG2197	response regulator
TthAA22_11080	COG0335	large ribosomal subunit rRNA binding
TthAA22_11090	COG0336	Belongs to the RNA methyltransferase TrmD family
TthAA22_11100	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthAA22_11110	COG1837	Belongs to the UPF0109 family
TthAA22_11120	COG0228	four-way junction DNA binding
TthAA22_11150	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA22_11160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA22_11160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA22_11170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthAA22_11190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthAA22_11210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthAA22_11220	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthAA22_11230	COG1702	phosphate starvation-inducible protein PhoH
TthAA22_11250	COG4864	UPF0365 protein
TthAA22_11270	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthAA22_11290	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA22_11290	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA22_11300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA22_11320	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthAA22_11330	COG1397	ADP-ribosylglycohydrolase
TthAA22_11340	COG2239	Acts as a magnesium transporter
TthAA22_11350	COG2304	oxidoreductase activity
TthAA22_11360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA22_11360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA22_11380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA22_11380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA22_11390	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthAA22_11400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthAA22_11410	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthAA22_11420	COG0006	proline dipeptidase activity
TthAA22_11440	COG0739	heme binding
TthAA22_11460	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthAA22_11470	COG0254	rRNA binding
TthAA22_11530	COG2001	Belongs to the MraZ family
TthAA22_11540	COG0275	rRNA processing
TthAA22_11570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthAA22_11590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA22_11600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthAA22_11610	COG0772	Belongs to the SEDS family
TthAA22_11620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthAA22_11630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthAA22_11640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthAA22_11680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthAA22_11710	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA22_11730	COG0159	tryptophan synthase activity
TthAA22_11740	COG0133	tryptophan synthase activity
TthAA22_11750	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthAA22_11760	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA22_11770	COG1744	ABC transporter substrate-binding protein PnrA-like
TthAA22_11780	COG3845	ABC transporter
TthAA22_11880	COG0438	transferase activity, transferring glycosyl groups
TthAA22_11890	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA22_11910	COG0039	L-malate dehydrogenase activity
TthAA22_11920	COG2819	hydrolase of the alpha beta superfamily
TthAA22_11930	COG0861	Integral membrane protein TerC family
TthAA22_11950	COG2181	nitrate reductase activity
TthAA22_11950	COG0247	lactate metabolic process
TthAA22_11970	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthAA22_11980	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthAA22_11990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthAA22_12010	COG0439	Biotin carboxylase
TthAA22_12020	COG0511	ligase activity, forming carbon-carbon bonds
TthAA22_12030	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthAA22_12070	COG0010	Belongs to the arginase family
TthAA22_12100	COG1100	Small GTP-binding protein
TthAA22_12120	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAA22_12130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA22_12150	COG2814	Major facilitator Superfamily
TthAA22_12160	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthAA22_12170	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA22_12180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthAA22_12190	COG0589	response to stress
TthAA22_12210	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA22_12210	COG0617	tRNA 3'-terminal CCA addition
TthAA22_12210	COG0517	IMP dehydrogenase activity
TthAA22_12220	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthAA22_12230	COG0745	RESPONSE REGULATOR receiver
TthAA22_12240	COG5002	protein histidine kinase activity
TthAA22_12250	COG1960	acyl-CoA dehydrogenase activity
TthAA22_12260	COG2086	electron transfer activity
TthAA22_12270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthAA22_12290	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA22_12300	COG1573	uracil-dna glycosylase
TthAA22_12310	COG1796	DNA polymerase
TthAA22_12310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA22_12340	COG2309	aminopeptidase activity
TthAA22_12360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA22_12380	COG1011	Hydrolase
TthAA22_12420	COG2873	o-acetylhomoserine
TthAA22_12430	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA22_12450	COG1126	abc transporter atp-binding protein
TthAA22_12480	COG0134	indole-3-glycerol-phosphate synthase activity
TthAA22_12490	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthAA22_12510	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthAA22_12540	COG0765	amino acid transport
TthAA22_12550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthAA22_12570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthAA22_12580	COG0569	domain protein
TthAA22_12590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA22_12600	COG1426	Protein conserved in bacteria
TthAA22_12620	COG2313	pseudouridylate synthase activity
TthAA22_12640	COG3001	Fructosamine kinase
TthAA22_12650	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA22_12670	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthAA22_12710	COG0012	GTP binding
TthAA22_12720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthAA22_12740	COG0424	maF-like protein
TthAA22_12770	COG0768	penicillin binding
TthAA22_12830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthAA22_12840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA22_12860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthAA22_12900	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA22_12920	COG1131	(ABC) transporter
TthAA22_12950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAA22_12980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthAA22_12990	COG0440	acetolactate synthase activity
TthAA22_13000	COG0028	Belongs to the TPP enzyme family
TthAA22_13010	COG0492	ferredoxin-NADP+ reductase activity
TthAA22_13020	COG4970	Tfp pilus assembly protein FimT
TthAA22_13030	COG2165	general secretion pathway protein
TthAA22_13040	COG4966	pilus assembly protein PilW
TthAA22_13080	COG2165	general secretion pathway protein
TthAA22_13100	COG4636	protein conserved in cyanobacteria
TthAA22_13150	COG0180	Tryptophanyl-tRNA synthetase
TthAA22_13160	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA22_13170	COG0066	3-isopropylmalate dehydratase activity
TthAA22_13180	COG0473	3-isopropylmalate dehydrogenase activity
TthAA22_13210	COG0300	oxidoreductase activity
TthAA22_13220	COG0129	dihydroxy-acid dehydratase activity
TthAA22_13240	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthAA22_13250	COG1177	transmembrane transport
TthAA22_13260	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthAA22_13270	COG3842	ATPase activity
TthAA22_13280	COG0772	Belongs to the SEDS family
TthAA22_13290	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthAA22_13300	COG2894	cell division
TthAA22_13310	COG1733	regulation of RNA biosynthetic process
TthAA22_13330	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA22_13330	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA22_13350	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA22_13360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA22_13370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA22_13380	COG0653	protein targeting
TthAA22_13390	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthAA22_13430	COG0393	Putative heavy-metal-binding
TthAA22_13440	COG1111	helicase
TthAA22_13440	COG1205	dead DEAH box helicase
TthAA22_13480	COG0358	DNA primase activity
TthAA22_13510	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA22_13520	COG0697	spore germination
TthAA22_13530	COG0612	Peptidase, M16
TthAA22_13540	COG0612	Peptidase, M16
TthAA22_13550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthAA22_13580	COG1394	ATPase activity, coupled to movement of substances
TthAA22_13590	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthAA22_13600	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthAA22_13610	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA22_13620	COG1527	subunit (C
TthAA22_13630	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA22_13650	COG1269	ATP hydrolysis coupled proton transport
TthAA22_13700	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA22_13720	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA22_13750	COG0419	ATPase involved in DNA repair
TthAA22_13760	COG0420	3'-5' exonuclease activity
TthAA22_13800	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthAA22_13810	COG2884	Cell division ATP-binding protein ftsE
TthAA22_13820	COG0793	Belongs to the peptidase S41A family
TthAA22_13830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA22_13830	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA22_13840	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthAA22_13850	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAA22_13870	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAA22_13880	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAA22_13890	COG1129	ABC transporter
TthAA22_13900	COG0746	molybdenum cofactor guanylyltransferase activity
TthAA22_13920	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA22_13960	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthAA22_13970	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA22_13980	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthAA22_14010	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA22_14030	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA22_14060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA22_14070	COG0788	formyltetrahydrofolate deformylase activity
TthAA22_14080	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthAA22_14090	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthAA22_14100	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthAA22_14150	COG0737	Belongs to the 5'-nucleotidase family
TthAA22_14160	COG0174	glutamine synthetase
TthAA22_14180	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA22_14220	COG0747	negative chemotaxis
TthAA22_14230	COG0601	transmembrane transport
TthAA22_14240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA22_14260	COG0285	dihydrofolate synthase activity
TthAA22_14270	COG1132	(ABC) transporter
TthAA22_14280	COG1132	(ABC) transporter
TthAA22_14290	COG0372	Belongs to the citrate synthase family
TthAA22_14300	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthAA22_14310	COG1482	cell wall glycoprotein biosynthetic process
TthAA22_14330	COG1515	deoxyribonuclease V activity
TthAA22_14350	COG0776	regulation of translation
TthAA22_14380	COG2197	response regulator
TthAA22_14390	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthAA22_14400	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthAA22_14410	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthAA22_14420	COG1324	tolerance protein
TthAA22_14430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA22_14470	COG2205	protein histidine kinase activity
TthAA22_14490	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthAA22_14520	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TthAA22_14530	COG0247	lactate metabolic process
TthAA22_14540	COG1139	Iron-sulfur cluster binding protein
TthAA22_14550	COG1556	Lactate utilization protein
TthAA22_14570	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthAA22_14580	COG0515	serine threonine protein kinase
TthAA22_14580	COG2815	serine threonine protein kinase
TthAA22_14590	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthAA22_14610	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthAA22_14650	COG0473	3-isopropylmalate dehydrogenase activity
TthAA22_14700	COG1450	Type ii and iii secretion system protein
TthAA22_14710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthAA22_14720	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthAA22_14730	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthAA22_14740	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthAA22_14740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA22_14750	COG0736	holo-[acyl-carrier-protein] synthase activity
TthAA22_14780	COG1160	GTP binding
TthAA22_14790	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthAA22_14800	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthAA22_14800	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthAA22_14810	COG2814	Major facilitator Superfamily
TthAA22_14820	COG0083	homoserine kinase activity
TthAA22_14840	COG0268	Binds directly to 16S ribosomal RNA
TthAA22_14860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthAA22_14870	COG0723	plastoquinol--plastocyanin reductase activity
TthAA22_14890	COG3088	subunit of a heme lyase
TthAA22_14890	COG4235	cytochrome complex assembly
TthAA22_14900	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA22_14910	COG1138	Cytochrome C-type biogenesis protein
TthAA22_14920	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthAA22_14930	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA22_14940	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA22_14950	COG4133	protoheme IX ABC transporter activity
TthAA22_14960	COG0785	Cytochrome C biogenesis protein
TthAA22_14970	COG3258	Cytochrome c
TthAA22_14990	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA22_15020	COG3258	Cytochrome c
TthAA22_15030	COG2010	Cytochrome c
TthAA22_15040	COG0737	Belongs to the 5'-nucleotidase family
TthAA22_15050	COG2010	Cytochrome c
TthAA22_15060	COG3258	Cytochrome c
TthAA22_15100	COG2010	Cytochrome c
TthAA22_15110	COG3842	ATPase activity
TthAA22_15180	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA22_15190	COG3360	Dodecin
TthAA22_15220	COG1024	Enoyl-CoA hydratase
TthAA22_15230	COG0813	purine-nucleoside phosphorylase activity
TthAA22_15240	COG1136	(ABC) transporter
TthAA22_15250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA22_15260	COG2045	Belongs to the ComB family
TthAA22_15280	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthAA22_15300	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthAA22_15320	COG0107	imidazoleglycerol-phosphate synthase activity
TthAA22_15330	COG0140	phosphoribosyl-ATP diphosphatase activity
TthAA22_15330	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthAA22_15340	COG1494	fructose-1,6-bisphosphatase
TthAA22_15350	COG0686	Belongs to the AlaDH PNT family
TthAA22_15360	COG0427	acetyl-CoA hydrolase
TthAA22_15370	COG0084	hydrolase, TatD family'
TthAA22_15380	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthAA22_15400	COG0017	Asparaginyl-tRNA synthetase
TthAA22_15420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA22_15450	COG2009	succinate dehydrogenase
TthAA22_15460	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA22_15520	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA22_15530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthAA22_15540	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthAA22_15550	COG0504	CTP synthase activity
TthAA22_15570	COG0069	glutamate synthase activity
TthAA22_15570	COG0067	glutamate synthase
TthAA22_15570	COG0070	glutamate synthase
TthAA22_15660	COG0840	transmembrane signaling receptor activity
TthAA22_15670	COG0305	Participates in initiation and elongation during chromosome replication
TthAA22_15690	COG0475	glutathione-regulated potassium exporter activity
TthAA22_15700	COG0517	IMP dehydrogenase activity
TthAA22_15700	COG0617	tRNA 3'-terminal CCA addition
TthAA22_15700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA22_15730	COG0475	glutathione-regulated potassium exporter activity
TthAA22_15740	COG0490	domain, Protein
TthAA22_15780	COG3118	belongs to the thioredoxin family
TthAA22_15860	COG0542	response to heat
TthAA22_15870	COG0789	Transcriptional regulator
TthAA22_15880	COG0484	heat shock protein binding
TthAA22_15890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthAA22_15900	COG0443	Heat shock 70 kDa protein
TthAA22_15910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthAA22_15920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthAA22_15930	COG0616	signal peptide processing
TthAA22_15960	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthAA22_15970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA22_15980	COG0714	Associated with various cellular activities
TthAA22_15990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAA22_15990	COG0574	Belongs to the PEP-utilizing enzyme family
TthAA22_16020	COG5002	protein histidine kinase activity
TthAA22_16020	COG3850	Histidine kinase
TthAA22_16070	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthAA22_16100	COG1011	Hydrolase
TthAA22_16130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthAA22_16160	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthAA22_16180	COG0047	phosphoribosylformylglycinamidine synthase activity
TthAA22_16200	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthAA22_16210	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthAA22_16220	COG0116	Belongs to the methyltransferase superfamily
TthAA22_16250	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthAA22_16260	COG0497	DNA recombination
TthAA22_16280	COG0604	alcohol dehydrogenase
TthAA22_16320	COG0585	pseudouridine synthase activity
TthAA22_16370	COG1595	DNA-templated transcription, initiation
TthAA22_16380	COG0557	exoribonuclease II activity
TthAA22_16390	COG0538	isocitrate dehydrogenase activity
TthAA22_16400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA22_16400	COG2022	thiamine diphosphate biosynthetic process
TthAA22_16410	COG0037	tRNA processing
TthAA22_16410	COG0590	tRNA wobble adenosine to inosine editing
TthAA22_16450	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA22_16470	COG0322	excinuclease ABC activity
TthAA22_16480	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA22_16490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA22_16500	COG1854	S-ribosylhomocysteine lyase activity
TthAA22_16530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAA22_16530	COG0519	Catalyzes the synthesis of GMP from XMP
TthAA22_16540	COG4636	protein conserved in cyanobacteria
TthAA22_16550	COG4274	PFAM GYD family protein
TthAA22_16560	COG0346	lactoylglutathione lyase activity
TthAA22_16570	COG0328	RNA-DNA hybrid ribonuclease activity
TthAA22_16580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA22_16590	COG2095	MarC family integral membrane protein
TthAA22_16600	COG1438	arginine binding
TthAA22_16610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthAA22_16620	COG1758	RNA polymerase activity
TthAA22_16630	COG0194	GDP metabolic process
TthAA22_16650	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthAA22_16660	COG2385	sporulation resulting in formation of a cellular spore
TthAA22_16670	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthAA22_16690	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA22_16770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA22_16780	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA22_16790	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_16800	COG0506	proline dehydrogenase activity
TthAA22_16830	COG0156	8-amino-7-oxononanoate synthase activity
TthAA22_16840	COG0732	type I restriction modification DNA specificity domain
TthAA22_16840	COG0827	DNA restriction-modification system
TthAA22_16860	COG0187	DNA topoisomerase II activity
TthAA22_16870	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthAA22_16880	COG0193	aminoacyl-tRNA hydrolase activity
TthAA22_16890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthAA22_16940	COG2815	serine threonine protein kinase
TthAA22_16940	COG0515	serine threonine protein kinase
TthAA22_16950	COG0631	protein serine/threonine phosphatase activity
TthAA22_16970	COG2814	Major facilitator Superfamily
TthAA22_16980	COG0113	porphobilinogen synthase activity
TthAA22_16990	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthAA22_17000	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthAA22_17050	COG4946	Tricorn protease homolog
TthAA22_17050	COG0823	Involved in the tonB-independent uptake of proteins
TthAA22_17050	COG1506	peptidase
TthAA22_17060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthAA22_17070	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthAA22_17110	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthAA22_17120	COG1011	Hydrolase
TthAA22_17170	COG0537	adenosine 5'-monophosphoramidase activity
TthAA22_17180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA22_17190	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthAA22_17200	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthAA22_17210	COG0071	Belongs to the small heat shock protein (HSP20) family
TthAA22_17220	COG2897	thiosulfate sulfurtransferase activity
TthAA22_17230	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA22_17250	COG1764	response to oxidative stress
TthAA22_17300	COG3842	ATPase activity
TthAA22_17310	COG0101	tRNA pseudouridine synthase activity
TthAA22_17320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA22_17330	COG0601	transmembrane transport
TthAA22_17370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA22_17400	COG1166	arginine decarboxylase activity
TthAA22_17410	COG3706	GGDEF domain
TthAA22_17420	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthAA22_17430	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthAA22_17440	COG1611	Belongs to the LOG family
TthAA22_17450	COG1193	negative regulation of DNA recombination
TthAA22_17460	COG0366	Alpha amylase catalytic
TthAA22_17520	COG3335	DDE superfamily endonuclease
TthAA22_17540	COG1175	transmembrane transport
TthAA22_17570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthAA22_17580	COG0142	geranyltranstransferase activity
TthAA22_17600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthAA22_17660	COG0203	ribosomal protein L17
TthAA22_17670	COG0202	RNA polymerase activity
TthAA22_17680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthAA22_17690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthAA22_17700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthAA22_17710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthAA22_17730	COG0563	adenylate kinase activity
TthAA22_17740	COG0201	protein transport
TthAA22_17790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthAA22_17800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthAA22_17810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthAA22_17860	COG0255	Belongs to the universal ribosomal protein uL29 family
TthAA22_17870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthAA22_17880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthAA22_17900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthAA22_17910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthAA22_17920	COG0089	rRNA binding
TthAA22_17930	COG0088	Forms part of the polypeptide exit tunnel
TthAA22_17950	COG0051	transcription antitermination factor activity, RNA binding
TthAA22_17960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA22_17970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA22_17980	COG0049	tRNA binding
TthAA22_18010	COG0442	prolyl-tRNA aminoacylation
TthAA22_18030	COG1115	amino acid carrier protein
TthAA22_18070	COG1489	DNA binding
TthAA22_18100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthAA22_18150	COG3253	May function as heme-dependent peroxidase
TthAA22_18160	COG0668	transmembrane transport
TthAA22_18180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthAA22_18190	COG2217	Heavy metal translocating P-type atpase
TthAA22_18230	COG0745	RESPONSE REGULATOR receiver
TthAA22_18240	COG2205	protein histidine kinase activity
TthAA22_18290	COG2226	methyltransferase
TthAA22_18330	COG2132	Multicopper oxidase
TthAA22_18350	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthAA22_18360	COG0822	iron-sulfur transferase activity
TthAA22_18400	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthAA22_18420	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthAA22_18430	COG0284	orotidine-5'-phosphate decarboxylase activity
TthAA22_18450	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA22_18470	COG0416	fatty acid biosynthetic process
TthAA22_18480	COG3118	belongs to the thioredoxin family
TthAA22_18490	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA22_18500	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthAA22_18520	COG0438	transferase activity, transferring glycosyl groups
TthAA22_18550	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthAA22_18560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA22_18570	COG3706	GGDEF domain
TthAA22_18640	COG0437	4 iron, 4 sulfur cluster binding
TthAA22_18670	COG0825	malonyl-CoA metabolic process
TthAA22_18680	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthAA22_18750	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthAA22_18800	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthAA22_18810	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthAA22_18820	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthAA22_18830	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthAA22_18850	COG4974	Belongs to the 'phage' integrase family
TthAA22_19010	COG0315	cyclic pyranopterin monophosphate synthase activity
TthAA22_19020	COG2860	membrane
TthAA22_19040	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthAA22_19070	COG0477	Major facilitator Superfamily
TthAA22_19080	COG1694	Mazg nucleotide pyrophosphohydrolase
TthAA22_19090	COG1803	Methylglyoxal synthase
TthAA22_19110	COG0301	tRNA thio-modification
TthAA22_19120	COG0154	amidase activity
TthAA22_19130	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthAA22_19180	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthAA22_19190	COG1607	acyl-coa hydrolase
TthAA22_19210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthAA22_19220	COG4149	molybdate abc transporter
TthAA22_19230	COG1840	ABC-type Fe3 transport system, periplasmic component
TthAA22_19260	COG0235	Class ii aldolase
TthAA22_19270	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthAA22_19280	COG0085	RNA polymerase activity
TthAA22_19300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthAA22_19310	COG1077	Cell shape determining protein MreB Mrl
TthAA22_19320	COG1418	mRNA catabolic process
TthAA22_19320	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthAA22_19330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthAA22_19340	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthAA22_19350	COG1546	Belongs to the CinA family
TthAA22_19350	COG1058	Belongs to the CinA family
TthAA22_19360	COG0354	folic acid binding
TthAA22_19390	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA22_19420	COG1175	transmembrane transport
TthAA22_19440	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthAA22_19460	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA22_19480	COG1136	(ABC) transporter
TthAA22_19480	COG0577	efflux transmembrane transporter activity
TthAA22_19490	COG4181	ATPase activity
TthAA22_19500	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA22_19530	COG0396	ATPase activity
TthAA22_19540	COG0719	Fe-S assembly protein
TthAA22_19550	COG0719	Fe-S assembly protein
TthAA22_19560	COG2146	nitrite reductase [NAD(P)H] activity
TthAA22_19580	COG0512	Glutamine amidotransferase of anthranilate synthase
TthAA22_19590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA22_19660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA22_19670	COG2226	methyltransferase
TthAA22_19680	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAA22_19690	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAA22_19720	COG1774	PSP1 C-terminal conserved region
TthAA22_19730	COG0470	DNA polymerase III
TthAA22_19810	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthAA22_19820	COG0302	gtp cyclohydrolase
TthAA22_19870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthAA22_19890	COG0395	ABC-type sugar transport system, permease component
TthAA22_19900	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthAA22_19910	COG1131	(ABC) transporter
TthAA22_19950	COG0556	nucleotide-excision repair
TthAA22_19960	COG0497	DNA recombination
TthAA22_19970	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthAA22_19980	COG0445	tRNA wobble uridine modification
TthAA22_20020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA22_20020	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthAA22_20030	COG1543	Belongs to the glycosyl hydrolase 57 family
TthAA22_20040	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA22_20050	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA22_20080	COG0189	ligase activity
TthAA22_20110	COG0066	3-isopropylmalate dehydratase activity
TthAA22_20120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA22_20150	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAA22_20160	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthAA22_20170	COG1960	acyl-CoA dehydrogenase activity
TthAA22_20180	COG0163	prenyltransferase activity
TthAA22_20250	COG2096	Adenosyltransferase
TthAA22_20280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthAA22_20290	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthAA22_20310	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthAA22_20320	COG0723	plastoquinol--plastocyanin reductase activity
TthAA22_20370	COG1653	transport
TthAA22_20380	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthAA22_20390	COG1960	acyl-CoA dehydrogenase activity
TthAA22_20410	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthAA22_20470	COG1131	(ABC) transporter
TthAA22_20520	COG3956	TIGRFAM MazG family protein
TthAA22_20560	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA22_20580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthAA22_20590	COG1937	Protein conserved in bacteria
TthAA22_20610	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthAA22_20610	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthAA22_20620	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthAA22_20630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA22_20670	COG0205	6-phosphofructokinase activity
TthAA22_20680	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthAA22_20700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthAA22_20730	COG2333	competence protein COMEC
TthAA22_20730	COG0658	competence protein
TthAA22_20740	COG1475	DNA binding
TthAA22_20750	COG1192	Involved in chromosome partitioning
TthAA22_20760	COG0357	Ribosomal RNA small subunit methyltransferase G
TthAA22_20780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA22_20800	COG0747	negative chemotaxis
TthAA22_20810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA22_20830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TthAA22_20840	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_20870	COG0395	ABC-type sugar transport system, permease component
TthAA22_20880	COG1175	transmembrane transport
TthAA22_20900	COG1609	Transcriptional regulator
TthAA22_20930	COG0863	Belongs to the N(4) N(6)-methyltransferase family
TthAA22_20980	COG1857	crispr-associated protein
TthAA22_21020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TthAA22_21030	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthAA22_21080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthAA22_21090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAA22_21120	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TthAA22_21130	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthAA22_21180	COG2801	Transposase and inactivated derivatives
TthAA22_21330	COG2205	protein histidine kinase activity
TthAA22_21340	COG0745	RESPONSE REGULATOR receiver
TthAA22_21350	COG2010	Cytochrome c
TthAA22_21440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TthAA22_21450	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TthAA22_21460	COG0363	glucosamine-6-phosphate deaminase activity
TthAA22_21490	COG0730	response to heat
TthAA22_21550	COG0671	phosphoesterase, PA-phosphatase related
TthAA22_21560	COG0745	RESPONSE REGULATOR receiver
TthAA22_21570	COG0745	RESPONSE REGULATOR receiver
TthAA22_21580	COG0642	Histidine kinase
TthAA22_21590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA22_21610	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA22_21650	COG2329	Antibiotic biosynthesis monooxygenase
TthAA22_21720	COG2801	Transposase and inactivated derivatives
TthAA22_21810	COG0745	RESPONSE REGULATOR receiver
TthAA22_21820	COG5002	protein histidine kinase activity
TthAA22_21820	COG3850	Histidine kinase
TthAA22_21950	COG1942	4-Oxalocrotonate Tautomerase
TthAA22_21970	COG2084	Dehydrogenase
TthAA22_22290	COG1797	cobyrinic acid a,c-diamide synthase activity
TthAA22_22320	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthAA22_22360	COG0588	phosphoglycerate mutase activity
TthAA22_22370	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthAA22_22380	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthAA22_22470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA22_22470	COG1648	precorrin-2 dehydrogenase activity
TthAA22_22480	COG0778	Nitroreductase
TthAA22_22490	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TthAA22_22520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthAA22_22550	COG1492	cobalamin metabolic process
TthAA22_22560	COG1785	Belongs to the alkaline phosphatase family
TthAA22_22570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TthAA22_22600	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA22_22630	COG1414	Transcriptional regulator
TthAA22_22640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthAA22_22660	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA22_22670	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_22700	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_22730	COG1175	transmembrane transport
TthAA22_22760	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA22_22780	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA22_22800	COG1562	ergosterol biosynthetic process
TthAA22_22820	COG2124	cytochrome p450
TthAA22_22870	COG1487	ribonuclease activity
TthAA22_22890	COG1304	FMN binding
TthAA22_22940	COG2801	Transposase and inactivated derivatives
TthAA22_22980	COG1085	galactose-1-phosphate uridylyltransferase
TthAA22_22990	COG3345	alpha-galactosidase
TthAA22_23040	COG4966	pilus assembly protein PilW
TthAA22_23080	COG1475	DNA binding
TthAA22_23090	COG1192	Involved in chromosome partitioning
TthAA22_23190	COG3256	nitric oxide reductase
TthAA22_23220	COG0535	radical SAM domain protein
TthAA22_23230	COG2010	Cytochrome c
TthAA22_23270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthAA22_23390	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA22_23410	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA22_23420	COG1252	NADH dehydrogenase
TthAA22_23440	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA22_23460	COG2010	Cytochrome c
TthAA22_23470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TthAA22_23480	COG1140	nitrate reductase beta subunit
TthAA22_23500	COG2181	nitrate reductase activity
TthAA22_23540	COG1063	alcohol dehydrogenase
TthAA22_23550	COG1802	Transcriptional regulator
TthAA22_23560	COG1402	creatininase
TthAA22_23580	COG0235	Class ii aldolase
TthAA22_23590	COG3181	Tripartite tricarboxylate transporter family receptor
TthAA22_23670	COG2151	metal-sulfur cluster biosynthetic enzyme
TthAA22_23680	COG1609	Transcriptional regulator
TthAA22_23720	COG1063	alcohol dehydrogenase
TthAA22_23730	COG2814	Major facilitator Superfamily
TthAA22_23750	COG0584	glycerophosphoryl diester phosphodiesterase
TthAA22_23770	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TthAA22_23800	COG2414	aldehyde ferredoxin oxidoreductase
TthAA22_23820	COG1110	DNA topoisomerase II activity
TthAA22_23830	COG4565	transcriptional regulatory protein
TthAA22_23850	COG3842	ATPase activity
TthAA22_23880	COG1378	Sugar-specific transcriptional regulator TrmB
TthAA22_23890	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthAA22_23900	COG0022	dehydrogenase e1 component
TthAA22_23920	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthAA22_23940	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
TthAA22_23940	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA22_23950	COG2271	Major facilitator Superfamily
TthAA22_24370	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA22_24400	COG1692	metallophosphoesterase
TthAA22_24410	COG0395	ABC-type sugar transport system, permease component
TthAA22_24420	COG1175	transmembrane transport
TthAA22_24430	COG1653	transport
TthAA22_24440	COG3842	ATPase activity
TthAA22_24480	COG0395	ABC-type sugar transport system, permease component
TthAA22_24490	COG1175	transmembrane transport
TthAA22_24640	COG1404	Belongs to the peptidase S8 family
TthAA22_24650	COG1879	ABC-type sugar transport system periplasmic component
TthAA22_24660	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthAA22_24670	COG1129	ABC transporter
TthAA22_24680	COG1869	D-ribose catabolic process
TthAA22_24690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAA22_24700	COG1609	Transcriptional regulator
TthAA22_24740	COG2801	Transposase and inactivated derivatives
TthAA22_24810	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA22_24860	COG1137	ATPase activity
TthAA22_24870	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
TthAA22_24880	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_24930	COG2188	Transcriptional regulator
TthAA22_24940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
TthAA22_24960	COG1960	acyl-CoA dehydrogenase activity
TthAA22_24970	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthAA22_24980	COG2030	dehydratase
TthAA22_25060	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA22_25070	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA22_25120	COG0588	phosphoglycerate mutase activity
TthAA22_25200	COG1525	nuclease
TthAA22_25340	COG2801	Transposase and inactivated derivatives
TthAA22_25350	COG1175	transmembrane transport
TthAA22_25370	COG3335	DDE superfamily endonuclease
TthAA22_25460	COG1475	DNA binding
TthAA22_25470	COG1192	Involved in chromosome partitioning
TthAA22_25530	COG1012	belongs to the aldehyde dehydrogenase family
TthAA22_25540	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthAA22_25550	COG1129	ABC transporter
TthAA22_25560	COG3962	Belongs to the TPP enzyme family
TthAA22_25580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAA22_25600	COG0673	inositol 2-dehydrogenase activity
TthAA22_25610	COG3718	enzyme involved in inositol metabolism
TthAA22_25620	COG1349	DNA-binding transcription factor activity
TthAA22_25720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthAA22_25800	COG2002	toxin-antitoxin pair type II binding
TthAA22_25950	COG3854	ATPases associated with a variety of cellular activities
TthAA22_25960	COG0497	DNA recombination
TthAA22_26140	COG1131	(ABC) transporter
TthAA22_t00340	COG0544	peptidyl-prolyl cis-trans isomerase activity