locus-tag	class	description
TthAA220_00010	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
TthAA220_00020	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
TthAA220_00030	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TthAA220_00040	ENOG4105CA9	Pyruvate kinase
TthAA220_00060	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TthAA220_00070	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
TthAA220_00090	ENOG41087YS	Phage shock protein A
TthAA220_00130	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TthAA220_00140	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TthAA220_00150	ENOG4105CZX	twitching motility protein
TthAA220_00160	ENOG4107QHF	type ii secretion system protein e
TthAA220_00170	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
TthAA220_00180	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
TthAA220_00190	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TthAA220_00200	ENOG4105VEQ	Cold shock protein
TthAA220_00210	ENOG4107T3P	ABC, transporter
TthAA220_00240	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
TthAA220_00260	ENOG4105CSH	Transporter
TthAA220_00280	ENOG4105C2X	Arabinose 5-phosphate isomerase
TthAA220_00290	ENOG41082T9	Membrane
TthAA220_00300	ENOG4105C6T	cysteine synthase
TthAA220_00310	ENOG4108YZY	peptidylprolyl cis-trans isomerase
TthAA220_00320	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
TthAA220_00340	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TthAA220_00350	ENOG4105CHM	Aminotransferase
TthAA220_00360	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
TthAA220_00410	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
TthAA220_00420	ENOG4105WMR	Protein CrcB homolog
TthAA220_00430	ENOG4105KJJ	Uncharacterized ACR, COG1993
TthAA220_00460	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
TthAA220_00490	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
TthAA220_00500	ENOG4105SYT	Methylenetetrahydrofolate reductase
TthAA220_00530	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
TthAA220_00540	ENOG4105C8B	TIGR00159 family
TthAA220_00560	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
TthAA220_00570	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
TthAA220_00580	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
TthAA220_00590	ENOG4105CHW	UPF0052 protein
TthAA220_00660	ENOG4107T65	Integrase
TthAA220_00700	ENOG4105BZ9	Cytochrome C oxidase, subunit I
TthAA220_00710	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
TthAA220_00720	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
TthAA220_00750	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TthAA220_00760	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
TthAA220_00770	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
TthAA220_00900	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
TthAA220_00920	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TthAA220_00940	ENOG41080TK	Universal stress protein
TthAA220_00970	ENOG4105PAD	Hydrolase
TthAA220_00980	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
TthAA220_00990	ENOG4108UKI	Enoyl-CoA hydratase
TthAA220_01000	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
TthAA220_01010	ENOG4105C7S	Dehydrogenase
TthAA220_01030	ENOG4105CDH	Citrulline--aspartate ligase
TthAA220_01040	ENOG4105CH7	arginosuccinase
TthAA220_01080	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
TthAA220_01100	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
TthAA220_01110	ENOG4105C89	phosphohexose isomerase
TthAA220_01130	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TthAA220_01160	ENOG4108RWN	rrna methyltransferase
TthAA220_01170	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
TthAA220_01180	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TthAA220_01190	ENOG4105CTD	carboxy-peptidase
TthAA220_01220	ENOG4108DBC	nitroreductase
TthAA220_01230	ENOG4105K4H	Nlp p60 protein
TthAA220_01250	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TthAA220_01270	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
TthAA220_01280	ENOG4105E2Z	phosphate ABC transporter (Permease
TthAA220_01290	ENOG4105C8U	phosphate abc transporter
TthAA220_01310	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TthAA220_01330	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
TthAA220_01340	ENOG4105G5W	regulator Fur family
TthAA220_01370	ENOG4105CY0	Metallo-Beta-Lactamase
TthAA220_01380	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TthAA220_01390	ENOG4105WDJ	50S ribosomal protein L33
TthAA220_01400	ENOG410683Z	Preprotein translocase SecE subunit
TthAA220_01410	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
TthAA220_01420	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TthAA220_01430	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TthAA220_01440	ENOG41082AW	Binds together with S18 to 16S ribosomal RNA (By similarity)
TthAA220_01450	ENOG4105Z8H	single-stranded DNA-binding protein
TthAA220_01460	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
TthAA220_01470	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
TthAA220_01480	ENOG4105DMF	Dehydrogenase
TthAA220_01510	ENOG4105E1F	short-chain dehydrogenase reductase
TthAA220_01520	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
TthAA220_01530	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
TthAA220_01620	ENOG4107QN2	dihydrolipoyl dehydrogenase
TthAA220_01650	ENOG4105ZVY	2-oxoisovalerate dehydrogenase, E1 component beta subunit
TthAA220_01660	ENOG4105CPP	Dehydrogenase, E1 component
TthAA220_01670	ENOG4107SUU	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
TthAA220_01680	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
TthAA220_01710	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
TthAA220_01720	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
TthAA220_01730	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TthAA220_01740	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TthAA220_01760	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
TthAA220_01770	ENOG4105FE9	pseudouridine synthase
TthAA220_01790	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TthAA220_01800	ENOG4105DCF	alanine dehydrogenase
TthAA220_01820	ENOG4105DP4	dak2 domain fusion protein ylov
TthAA220_01850	ENOG4105D60	lipoprotein releasing system transmembrane protein
TthAA220_01860	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
TthAA220_01870	ENOG4108VZM	50s ribosomal protein L10
TthAA220_01880	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
TthAA220_01890	ENOG4105W8H	transhydrogenase (subunit alpha
TthAA220_01900	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
TthAA220_01920	ENOG4108594	Permease of the drug metabolite transporter
TthAA220_01960	ENOG4105C0P	Mg chelatase subunit ChlI
TthAA220_01970	ENOG4108J2R	molybdopterin oxidoreductase
TthAA220_01990	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TthAA220_02010	ENOG4105CH5	extracellular solute-binding protein, family 7
TthAA220_02020	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TthAA220_02040	ENOG4105C57	major facilitator superfamily
TthAA220_02060	ENOG4105EEI	dihydropteroate synthase
TthAA220_02070	ENOG4105KRF	dihydroneopterin aldolase
TthAA220_02090	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TthAA220_02100	ENOG4108ZF3	Phosphatase
TthAA220_02110	ENOG4107RSM	transcriptional regulator
TthAA220_02120	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
TthAA220_02130	ENOG4107QSN	dihydrolipoamide acetyltransferase
TthAA220_02160	ENOG4105C0B	DNA polymerase III (alpha subunit)
TthAA220_02190	ENOG4108Z4U	Ferredoxin
TthAA220_02220	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TthAA220_02230	ENOG4105C5R	Aminotransferase
TthAA220_02240	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
TthAA220_02250	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
TthAA220_02260	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
TthAA220_02290	ENOG4107Z3H	Transcriptional regulator, TetR family
TthAA220_02330	ENOG4105K8N	protein family UPF0079, ATPase
TthAA220_02340	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
TthAA220_02350	ENOG4105C8T	Leucyl-tRNA synthetase
TthAA220_02390	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
TthAA220_02430	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
TthAA220_02440	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TthAA220_02460	ENOG4106855	Competence protein
TthAA220_02480	ENOG4108VAU	general secretion pathway protein G
TthAA220_02530	ENOG4107QHF	type ii secretion system protein e
TthAA220_02540	ENOG4105D7Q	type ii secretion system
TthAA220_02560	ENOG4105I08	Pseudouridine synthase
TthAA220_02580	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TthAA220_02590	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TthAA220_02600	ENOG4105BZU	Histidine kinase
TthAA220_02610	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
TthAA220_02620	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
TthAA220_02640	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
TthAA220_02660	ENOG4107QPV	Serine Threonine protein kinase
TthAA220_02670	ENOG4105KME	endoribonuclease L-psp
TthAA220_02720	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
TthAA220_02730	ENOG4108RZ4	Short-chain dehydrogenase reductase Sdr
TthAA220_02760	ENOG4105DHP	deoxycytidine triphosphate deaminase
TthAA220_02770	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
TthAA220_02780	ENOG4107ZZY	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
TthAA220_02790	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
TthAA220_02820	ENOG4105CM2	brancheD-chain amino acid aminotransferase
TthAA220_02830	ENOG4105DND	Transcriptional regulator
TthAA220_02840	ENOG4105WEF	catalase
TthAA220_02860	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
TthAA220_02870	ENOG4108UW5	maltose o-acetyltransferase
TthAA220_02880	ENOG4105SFS	phosphoesterase RecJ domain protein
TthAA220_02900	ENOG4105E3H	phosphoglycerate mutase
TthAA220_02920	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
TthAA220_02930	ENOG4105D5T	phosphonate abc transporter
TthAA220_02970	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TthAA220_02980	ENOG4105C1J	atp-dependent rna helicase
TthAA220_02990	ENOG4105CV1	Transketolase (EC 2.2.1.1)
TthAA220_03080	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
TthAA220_03090	ENOG4105C0H	protease
TthAA220_03100	ENOG4105C75	arginyL-tRNA synthetase
TthAA220_03110	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TthAA220_03120	ENOG4107WFQ	NADH-quinone oxidoreductase, chain M
TthAA220_03130	ENOG4105D65	subunit l
TthAA220_03140	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TthAA220_03150	ENOG41087XN	oxidoreductase
TthAA220_03160	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TthAA220_03170	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
TthAA220_03180	ENOG4108IEH	NADH dehydrogenase subunit g
TthAA220_03190	ENOG4107EEP	NADH dehydrogenase (quinone) (EC 1.6.99.5)
TthAA220_03200	ENOG4105GKE	subunit e
TthAA220_03210	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TthAA220_03220	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthAA220_03230	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TthAA220_03240	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthAA220_03250	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TthAA220_03270	ENOG4105VIZ	double-strand break repair protein
TthAA220_03350	ENOG4105ECY	inositol monophosphatase
TthAA220_03360	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
TthAA220_03380	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TthAA220_03400	ENOG41073R8	VanW family
TthAA220_03410	ENOG4105CDA	abc transporter atp-binding protein
TthAA220_03470	ENOG4105EU8	FAD linked oxidase domain protein
TthAA220_03500	ENOG4105C25	Primosomal protein n'
TthAA220_03540	ENOG4108ZAF	Molybdopterin
TthAA220_03550	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
TthAA220_03570	ENOG4105BZU	Histidine kinase
TthAA220_03580	ENOG4105CB5	ATP-dependent DNA helicase recG
TthAA220_03590	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
TthAA220_03610	ENOG4105DGU	Histone deacetylase
TthAA220_03640	ENOG4105CBD	Diacylglycerol kinase
TthAA220_03650	ENOG4105CHM	Aminotransferase
TthAA220_03680	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
TthAA220_03690	ENOG4106633	50S ribosomal protein l28
TthAA220_03710	ENOG4105CQB	FAD linked oxidase domain protein
TthAA220_03760	ENOG4105CPC	Aldo Keto reductase
TthAA220_03790	ENOG4105CUJ	penicillin amidase
TthAA220_03820	ENOG4105DAN	ATP-dependent protease
TthAA220_03830	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
TthAA220_03850	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TthAA220_03860	ENOG4108ZHD	aig2 family
TthAA220_03870	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
TthAA220_03890	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
TthAA220_03900	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
TthAA220_03930	ENOG4105EAH	synthase
TthAA220_03950	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TthAA220_03960	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TthAA220_03970	ENOG4105C3M	thioredoxin reductase
TthAA220_03990	ENOG410850P	UPF0102 protein
TthAA220_04000	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TthAA220_04030	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
TthAA220_04040	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
TthAA220_04100	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TthAA220_04110	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
TthAA220_04120	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
TthAA220_04130	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TthAA220_04140	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
TthAA220_04200	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
TthAA220_04260	ENOG4105E2A	Dehydrogenase
TthAA220_04320	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TthAA220_04330	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
TthAA220_04340	ENOG4105C34	Pseudouridine synthase
TthAA220_04370	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
TthAA220_04380	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
TthAA220_04390	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TthAA220_04400	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
TthAA220_04410	ENOG4105CHR	reductase
TthAA220_04420	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
TthAA220_04430	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TthAA220_04440	ENOG41067VY	50S ribosomal protein L32
TthAA220_04520	ENOG4108TVJ	Nitroreductase
TthAA220_04550	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TthAA220_04560	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
TthAA220_04570	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
TthAA220_04580	ENOG4107Y7Q	pfkb domain protein
TthAA220_04590	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TthAA220_04640	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TthAA220_04660	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
TthAA220_04670	ENOG4108IUZ	ABC transporter
TthAA220_04700	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TthAA220_04710	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
TthAA220_04720	ENOG4107K5T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
TthAA220_04730	ENOG4105C0Z	ABC transporter
TthAA220_04740	ENOG4108IQE	Amp-dependent synthetase and ligase
TthAA220_04750	ENOG4105C32	Amino acid ABC transporter (Permease)
TthAA220_04760	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TthAA220_04780	ENOG4108IV0	ABC, transporter
TthAA220_04790	ENOG4105DIK	(ABC) transporter
TthAA220_04800	ENOG4105CC5	ABC transporter
TthAA220_04820	ENOG4107QI6	Cysteine desulfurase
TthAA220_04830	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
TthAA220_04840	ENOG4105CAT	Cytidine monophosphate kinase
TthAA220_04870	ENOG4105CHR	reductase
TthAA220_04910	ENOG4105CAY	ferredoxin--nadp reductase
TthAA220_04940	ENOG4107QRA	Extracellular solute-binding protein, family 5
TthAA220_04960	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TthAA220_04990	ENOG41080XP	Cbs domain
TthAA220_05000	ENOG4105DGU	Histone deacetylase
TthAA220_05010	ENOG4106C07	ThiamineS Protein
TthAA220_05020	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TthAA220_05030	ENOG4105CG3	alpha amylase, catalytic region
TthAA220_05050	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
TthAA220_05100	ENOG4108HQS	Glycine betaine
TthAA220_05110	ENOG4108IJ7	Glycine betaine
TthAA220_05120	ENOG4105CG3	alpha amylase, catalytic region
TthAA220_05130	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TthAA220_05140	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TthAA220_05150	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
TthAA220_05170	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
TthAA220_05180	ENOG4105D6E	homoserine dehydrogenase
TthAA220_05250	ENOG4106YGA	NADH dehydrogenase (quinone)
TthAA220_05270	ENOG4105CSA	Coproporphyrinogen iii oxidase
TthAA220_05310	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
TthAA220_05320	ENOG4105CQB	FAD linked oxidase domain protein
TthAA220_05330	ENOG4105CQB	FAD linked oxidase domain protein
TthAA220_05340	ENOG4107R9S	Malate synthase
TthAA220_05350	ENOG4107HP6	Transcriptional regulator
TthAA220_05360	ENOG4105KNI	merR family transcriptional Regulator
TthAA220_05370	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TthAA220_05380	ENOG4108Z7R	Chaperone CsaA
TthAA220_05390	ENOG4105DZS	Phenylacetate-CoA ligase
TthAA220_05410	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
TthAA220_05420	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TthAA220_05460	ENOG4107TS3	membrane protein, TerC
TthAA220_05470	ENOG4105VG1	fes assembly suf system protein
TthAA220_05480	ENOG4107R1I	NAD-dependent malic enzyme
TthAA220_05510	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
TthAA220_05520	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
TthAA220_05530	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA220_05540	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA220_05550	ENOG4105DTN	riboflavin biosynthesis protein ribF
TthAA220_05560	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
TthAA220_05600	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TthAA220_05610	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
TthAA220_05620	ENOG4105CFH	Aspartokinase
TthAA220_05640	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TthAA220_05650	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
TthAA220_05660	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
TthAA220_05670	ENOG4108JVH	Protein of unknown function DUF43
TthAA220_05680	ENOG4105CTP	PilT protein domain protein
TthAA220_05690	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TthAA220_05710	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TthAA220_05770	ENOG4105CX6	glutaminyL-tRNA synthetase
TthAA220_05790	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
TthAA220_05800	ENOG410868C	50s ribosomal protein l35
TthAA220_05810	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
TthAA220_05830	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TthAA220_05840	ENOG41080X4	futalosine nucleosidase
TthAA220_05850	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
TthAA220_05860	ENOG4105C9Q	fumarate hydratase class II
TthAA220_05900	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TthAA220_05910	ENOG4105DFA	alanine racemase domain protein
TthAA220_05940	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TthAA220_05950	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TthAA220_05980	ENOG4105CPQ	Dehydrogenase
TthAA220_06020	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TthAA220_06030	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TthAA220_06040	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
TthAA220_06080	ENOG4105DBI	uridine monophosphokinase
TthAA220_06090	ENOG4108IJ9	(ABC) transporter
TthAA220_06120	ENOG4108UIC	UPF0340 protein
TthAA220_06160	ENOG4105K6V	RNA polymerase
TthAA220_06200	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TthAA220_06220	ENOG4105C0Z	ABC transporter
TthAA220_06230	ENOG4108IV0	ABC, transporter
TthAA220_06250	ENOG4105CP9	extracellular ligand-binding receptor
TthAA220_06300	ENOG4105CH5	extracellular solute-binding protein, family 7
TthAA220_06310	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TthAA220_06320	ENOG4105DSE	periplasmic solute binding protein
TthAA220_06350	ENOG4105C1Q	protoporphyrinogen oxidase
TthAA220_06360	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
TthAA220_06370	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
TthAA220_06380	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
TthAA220_06410	ENOG4105CEY	Amp-dependent synthetase and ligase
TthAA220_06420	ENOG4105DXM	phenylacetic acid degradation protein
TthAA220_06430	ENOG4105C1G	acyl-Coa dehydrogenase
TthAA220_06460	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
TthAA220_06480	ENOG41066UU	tRNA (Adenine-N1-)-methyltransferase
TthAA220_06500	ENOG4105X0R	protein from nitrogen regulatory protein P-II
TthAA220_06510	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
TthAA220_06530	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
TthAA220_06540	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TthAA220_06550	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
TthAA220_06560	ENOG4105DAP	Nicotinate phosphoribosyltransferase
TthAA220_06570	ENOG4105C3R	Methionine synthase
TthAA220_06580	ENOG4105CRQ	synthase (Component I)
TthAA220_06600	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
TthAA220_06630	ENOG4105D48	metallophosphoesterase
TthAA220_06640	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
TthAA220_06670	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
TthAA220_06680	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
TthAA220_06790	ENOG4105D3Q	Sugar transferase
TthAA220_06810	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
TthAA220_06860	ENOG4107T1U	Catalyzes the synthesis of activated sulfate (By similarity)
TthAA220_06940	ENOG4105D1F	ATP-binding protein
TthAA220_06960	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TthAA220_07030	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TthAA220_07060	ENOG4107RIQ	Sulfate adenylate transferase
TthAA220_07070	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TthAA220_07080	ENOG4107TSN	permease
TthAA220_07090	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
TthAA220_07100	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TthAA220_07110	ENOG4105EXQ	uroporphyrinogen iii synthase hem4
TthAA220_07120	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
TthAA220_07140	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
TthAA220_07150	ENOG4108G2S	Thiamine biosynthesis protein thiS
TthAA220_07160	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
TthAA220_07180	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
TthAA220_07190	ENOG41079KZ	Major Facilitator Superfamily
TthAA220_07200	ENOG4105DWF	phosphomethylpyrimidine kinase
TthAA220_07280	ENOG4105E2R	ROK family
TthAA220_07290	ENOG4105CHU	acetyl-coa acetyltransferase
TthAA220_07330	ENOG4108IV0	ABC, transporter
TthAA220_07340	ENOG4105C0Z	ABC transporter
TthAA220_07360	ENOG4105C32	Amino acid ABC transporter (Permease)
TthAA220_07390	ENOG4108Z7G	MaoC domain protein dehydratase
TthAA220_07410	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
TthAA220_07420	ENOG4105CEY	Amp-dependent synthetase and ligase
TthAA220_07450	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TthAA220_07470	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
TthAA220_07490	ENOG4105CHV	Transcription elongation factor NusA
TthAA220_07500	ENOG410836C	Required for maturation of 30S ribosomal subunits (By similarity)
TthAA220_07510	ENOG4105DR5	peptidase
TthAA220_07520	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
TthAA220_07530	ENOG4107YCR	Transcriptional regulator, ARSR family
TthAA220_07540	ENOG4105C59	p-type ATPase
TthAA220_07550	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
TthAA220_07560	ENOG4105C5S	asparaginyl-tRNA synthetase
TthAA220_07580	ENOG4107ZY0	Phenazine biosynthesis-like protein
TthAA220_07590	ENOG4105C9M	aspartyl-trna synthetase
TthAA220_07600	ENOG4105CUT	histidyl-tRNA synthetase
TthAA220_07620	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TthAA220_07630	ENOG4105E0C	molybdate abc transporter
TthAA220_07640	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
TthAA220_07660	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TthAA220_07700	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
TthAA220_07710	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TthAA220_07730	ENOG4108KGH	TRANSCRIPTIONal
TthAA220_07740	ENOG4107QM5	aconitate hydratase
TthAA220_07770	ENOG4105BZS	acriflavin resistance protein
TthAA220_07830	ENOG4105KG3	cytidine deaminase
TthAA220_07850	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TthAA220_07890	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
TthAA220_07910	ENOG4105EHG	Permease protein
TthAA220_07920	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
TthAA220_07940	ENOG4105CHR	reductase
TthAA220_07960	ENOG4107S1E	Beta-lactamase
TthAA220_07990	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
TthAA220_08010	ENOG4105DWV	Homoserine O-trans-acetylase
TthAA220_08020	ENOG4108IQK	o-acetylhomoserine
TthAA220_08050	ENOG4107WTH	Galactitol-1-phosphate dehydrogenase
TthAA220_08070	ENOG4105KXX	peptidase s58 dmpa
TthAA220_08080	ENOG4105CH5	extracellular solute-binding protein, family 7
TthAA220_08100	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TthAA220_08120	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TthAA220_08130	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
TthAA220_08140	ENOG4108IY8	ABC, transporter
TthAA220_08150	ENOG4105D2X	ABC transporter substrate-binding protein
TthAA220_08170	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
TthAA220_08260	ENOG4105C5I	Dehydrogenase
TthAA220_08280	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TthAA220_08300	ENOG4105C1G	acyl-Coa dehydrogenase
TthAA220_08310	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
TthAA220_08330	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
TthAA220_08340	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TthAA220_08380	ENOG4105CQB	FAD linked oxidase domain protein
TthAA220_08390	ENOG4105BZU	Histidine kinase
TthAA220_08410	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TthAA220_08420	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
TthAA220_08430	ENOG4108YYC	ycei family
TthAA220_08440	ENOG4108XHF	Pfam:DUF178
TthAA220_08450	ENOG4105DVY	radical SAM domain protein
TthAA220_08480	ENOG4105ETE	Transcriptional regulator (LacI family
TthAA220_08490	ENOG41071YG	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TthAA220_08500	ENOG4105ERH	Fumarylacetoacetate hydrolase
TthAA220_08520	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
TthAA220_08530	ENOG4107QNG	Phosphoribosylglycinamide synthetase
TthAA220_08540	ENOG4108IRC	dna polymerase iii
TthAA220_08560	ENOG4105BZU	Histidine kinase
TthAA220_08600	ENOG4107QN1	sodium solute
TthAA220_08620	ENOG4105CDY	transcriptional regulatory protein
TthAA220_08630	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
TthAA220_08640	ENOG4107ZQN	disulfide bond
TthAA220_08650	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
TthAA220_08660	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TthAA220_08670	ENOG4105CNU	cell division protein FtsK
TthAA220_08700	ENOG4105W87	Cbs domain
TthAA220_08740	ENOG4108Z4T	Peptidase M50
TthAA220_08750	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
TthAA220_08770	ENOG41082J7	Rhodanese domain protein
TthAA220_08800	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
TthAA220_08810	ENOG4107ZT5	Thiol disulfide interchange protein
TthAA220_08820	ENOG4105ED1	spovr family
TthAA220_08830	ENOG4106AKX	UPF0229 protein
TthAA220_08840	ENOG4105CYN	Serine protein kinase
TthAA220_08910	ENOG4105MCT	stage V sporulation protein S
TthAA220_08920	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TthAA220_08930	ENOG4105II7	pyrroline-5-carboxylate reductase
TthAA220_08950	ENOG4105C3Q	Glycosyl transferase, family 2
TthAA220_08960	ENOG4105DZP	Membrane-associated zinc metalloprotease
TthAA220_08970	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
TthAA220_08990	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
TthAA220_09000	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TthAA220_09010	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
TthAA220_09020	ENOG4105CE9	30S ribosomal protein S2
TthAA220_09030	ENOG4108JPW	Aminotransferase
TthAA220_09040	ENOG4108YZ4	nudix hydrolase
TthAA220_09070	ENOG4105KHN	chorismate mutase
TthAA220_09100	ENOG4107Y3Y	amidohydrolase
TthAA220_09120	ENOG4105DTQ	mandelate racemase muconate lactonizing
TthAA220_09130	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TthAA220_09150	ENOG4108UQV	Membrane
TthAA220_09160	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
TthAA220_09180	ENOG4105C6X	Major Facilitator
TthAA220_09190	ENOG4108SHN	Glycosyl transferase, family 2
TthAA220_09200	ENOG4107V8I	Glycosyl transferases group 1
TthAA220_09230	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
TthAA220_09280	ENOG4105CHU	acetyl-coa acetyltransferase
TthAA220_09290	ENOG4105C1G	acyl-Coa dehydrogenase
TthAA220_09300	ENOG4105C8N	cysteinyl-tRNA synthetase
TthAA220_09310	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
TthAA220_09320	ENOG41068KF	Universal stress protein
TthAA220_09370	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TthAA220_09390	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
TthAA220_09400	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
TthAA220_09410	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
TthAA220_09420	ENOG4107ZYJ	bioY protein
TthAA220_09430	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
TthAA220_09440	ENOG4105BZA	Phosphoglycerate kinase
TthAA220_09470	ENOG4105C8Y	Acetylornithine aminotransferase
TthAA220_09480	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
TthAA220_09490	ENOG41081CK	Memo-like protein
TthAA220_09500	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
TthAA220_09510	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
TthAA220_09520	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TthAA220_09530	ENOG4106H78	methyltransferase
TthAA220_09540	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
TthAA220_09550	ENOG4105DC1	bifunctional purine biosynthesis protein purh
TthAA220_09560	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
TthAA220_09590	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
TthAA220_09650	ENOG4105CIG	ABC transporter
TthAA220_09700	ENOG4105CP7	Triose-phosphate isomerase
TthAA220_09710	ENOG4105ECK	Fatty Acid Desaturase
TthAA220_09740	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
TthAA220_09750	ENOG4105EPR	degv family
TthAA220_09760	ENOG4105EPR	degv family
TthAA220_09780	ENOG410600Z	Regulatory protein MarR
TthAA220_09820	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TthAA220_09850	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
TthAA220_09870	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TthAA220_09890	ENOG4105C26	Dehydrogenase
TthAA220_09900	ENOG4105EFA	4-hydroxyphenylacetate
TthAA220_09910	ENOG4105MXW	flavin reductase domain protein, FMN-binding
TthAA220_09940	ENOG4105C32	Amino acid ABC transporter (Permease)
TthAA220_09950	ENOG4105C0Z	ABC transporter
TthAA220_09960	ENOG4108IV0	ABC, transporter
TthAA220_09970	ENOG4107YAU	phenylacetic acid degradation protein
TthAA220_09980	ENOG4105DZS	Phenylacetate-CoA ligase
TthAA220_10000	ENOG4105DXM	phenylacetic acid degradation protein
TthAA220_10040	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
TthAA220_10060	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TthAA220_10120	ENOG4107NFR	Fructose-1,6-bisphosphatase
TthAA220_10140	ENOG4108UQY	Iron-storage protein
TthAA220_10150	ENOG4108IYU	L-aspartate oxidase
TthAA220_10160	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TthAA220_10170	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
TthAA220_10180	ENOG4105C7Z	Conserved Protein
TthAA220_10190	ENOG4105CHU	acetyl-coa acetyltransferase
TthAA220_10200	ENOG4105P4J	Allophanate hydrolase, subunit 1
TthAA220_10210	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
TthAA220_10250	ENOG4105BZU	Histidine kinase
TthAA220_10260	ENOG4105CPI	Metal Dependent Phosphohydrolase
TthAA220_10290	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TthAA220_10300	ENOG4105C26	Dehydrogenase
TthAA220_10320	ENOG4105C9X	ppx gppa phosphatase
TthAA220_10330	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
TthAA220_10340	ENOG4105C4R	Atp-dependent dna helicase
TthAA220_10370	ENOG4105MKU	Transcriptional regulator
TthAA220_10380	ENOG4105CJ1	ABC, transporter
TthAA220_10390	ENOG4107QWP	ABC-2 type transporter
TthAA220_10460	ENOG4107U9H	DNA polymerase
TthAA220_10510	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
TthAA220_10520	ENOG4105KHC	sulfurtransferase
TthAA220_10530	ENOG4105EJQ	L-serine dehydratase
TthAA220_10540	ENOG4105WH1	Two component transcriptional regulator luxr family
TthAA220_10550	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
TthAA220_10560	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
TthAA220_10570	ENOG4106GF2	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
TthAA220_10580	ENOG4105VB6	UPF0109 protein
TthAA220_10590	ENOG4105K5M	30s ribosomal protein S16
TthAA220_10600	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TthAA220_10650	ENOG4105CRK	lysyL-tRNA synthetase
TthAA220_10660	ENOG4105RTX	GreA GreB family elongation factor
TthAA220_10680	ENOG41080IJ	Diacylglycerol kinase
TthAA220_10690	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
TthAA220_10700	ENOG4105C9A	Phoh family
TthAA220_10720	ENOG4105DI5	UPF0365 protein
TthAA220_10740	ENOG4105E2X	shikimate dehydrogenase
TthAA220_10760	ENOG4105C2M	dna polymerase I
TthAA220_10770	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TthAA220_10790	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
TthAA220_10800	ENOG41065RQ	ADP-ribosylation crystallin J1
TthAA220_10810	ENOG4105CJW	magnesium transporter
TthAA220_10830	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
TthAA220_10850	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
TthAA220_10860	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
TthAA220_10870	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
TthAA220_10880	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TthAA220_10890	ENOG4105DC7	peptidase M24
TthAA220_10910	ENOG4105FRN	stage II sporulation protein
TthAA220_10930	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TthAA220_10940	ENOG41082DI	50s ribosomal protein l31
TthAA220_10960	ENOG4108V6E	Cell division protein mraZ
TthAA220_10970	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
TthAA220_11000	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
TthAA220_11020	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
TthAA220_11030	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
TthAA220_11040	ENOG4105CNI	cell division protein FtsW
TthAA220_11050	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
TthAA220_11060	ENOG4105DFU	Cell wall formation (By similarity)
TthAA220_11070	ENOG4107QWW	Cell wall formation (By similarity)
TthAA220_11090	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
TthAA220_11110	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
TthAA220_11140	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
TthAA220_11160	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
TthAA220_11170	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TthAA220_11180	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
TthAA220_11190	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
TthAA220_11200	ENOG4105DIH	basic membrane
TthAA220_11210	ENOG4108JQ9	ABC transporter
TthAA220_11310	ENOG4105CPK	Glycosyl transferase (Group 1
TthAA220_11320	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TthAA220_11340	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TthAA220_11350	ENOG4108SA1	esterase
TthAA220_11360	ENOG4107TS3	membrane protein, TerC
TthAA220_11380	ENOG4105DF6	Fe-S oxidoreductase
TthAA220_11410	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
TthAA220_11420	ENOG41082MB	Involved in the transcription termination process (By similarity)
TthAA220_11440	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
TthAA220_11450	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
TthAA220_11460	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
TthAA220_11500	ENOG4105CYW	agmatinase
TthAA220_11530	ENOG4105CXV	gliding motility protein
TthAA220_11550	ENOG4105NAA	Cytochrome C oxidase, subunit II
TthAA220_11560	ENOG4107RQ2	Cytochrome c oxidase, subunit I
TthAA220_11580	ENOG4107RGD	Major Facilitator superfamily
TthAA220_11590	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TthAA220_11600	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TthAA220_11610	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TthAA220_11620	ENOG4105CN5	Metallo-Beta-Lactamase
TthAA220_11630	ENOG4108YV4	Universal stress protein
TthAA220_11680	ENOG4105CJW	magnesium transporter
TthAA220_11690	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
TthAA220_11700	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
TthAA220_11710	ENOG4105BZU	Histidine kinase
TthAA220_11720	ENOG4105C1G	acyl-Coa dehydrogenase
TthAA220_11730	ENOG4105BZJ	Electron transfer flavoprotein
TthAA220_11740	ENOG4105C10	Electron transfer flavoprotein
TthAA220_11760	ENOG4108HNZ	carboxyl transferase
TthAA220_11770	ENOG4105E50	uracil-dna glycosylase
TthAA220_11780	ENOG4105DCG	PHP domain protein
TthAA220_11810	ENOG4105C88	aminopeptidase
TthAA220_11830	ENOG4105IJJ	transcriptional regulator, crp fnr family
TthAA220_11890	ENOG4108FXY	Cys/Met metabolism PLP-dependent enzyme
TthAA220_11920	ENOG4105CDA	abc transporter atp-binding protein
TthAA220_11950	ENOG4105DK0	Indole-3-glycerol phosphate synthase
TthAA220_11960	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
TthAA220_11980	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
TthAA220_12000	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TthAA220_12010	ENOG4105E5Q	amino acid AbC transporter
TthAA220_12020	ENOG4105EAB	amino acid AbC transporter
TthAA220_12040	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
TthAA220_12050	ENOG4105C1A	potassium transporter peripheral membrane
TthAA220_12060	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TthAA220_12070	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
TthAA220_12080	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
TthAA220_12110	ENOG4105KJF	protein tyrosine phosphatase
TthAA220_12130	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
TthAA220_12170	ENOG4105C3G	gtp-binding protein
TthAA220_12180	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TthAA220_12200	ENOG4108Z03	MAF-like protein
TthAA220_12230	ENOG4105CJN	penicillin-binding protein
TthAA220_12240	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
TthAA220_12250	ENOG4108SJC	Membrane
TthAA220_12290	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
TthAA220_12300	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TthAA220_12320	ENOG4105DBV	ornithine carbamoyltransferase
TthAA220_12360	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TthAA220_12380	ENOG4105CJ1	ABC, transporter
TthAA220_12410	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TthAA220_12430	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TthAA220_12440	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
TthAA220_12460	ENOG4105C7K	acetolactate synthase
TthAA220_12470	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
TthAA220_12580	ENOG4105D5G	Transposase
TthAA220_12620	ENOG4105C31	Tryptophanyl-tRNA synthetase
TthAA220_12630	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TthAA220_12640	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TthAA220_12650	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TthAA220_12690	ENOG4105C01	Dihydroxy-acid dehydratase
TthAA220_12710	ENOG4107RUE	extracellular solute-binding protein family 1
TthAA220_12720	ENOG4105D38	putrescine abc transporter
TthAA220_12730	ENOG4105F38	ABC transporter, permease
TthAA220_12740	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TthAA220_12750	ENOG4105CNI	cell division protein FtsW
TthAA220_12760	ENOG4108CHF	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
TthAA220_12770	ENOG4107QMS	site-determining protein
TthAA220_12820	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TthAA220_12830	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TthAA220_12840	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TthAA220_12850	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
TthAA220_12860	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TthAA220_12900	ENOG4105K8R	UPF0145 protein
TthAA220_12910	ENOG4108I5C	dEAD DEAH box helicase
TthAA220_12940	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
TthAA220_12950	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
TthAA220_12970	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
TthAA220_12980	ENOG4107Y9U	Membrane
TthAA220_12990	ENOG4105C1V	Peptidase, M16
TthAA220_13040	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TthAA220_13050	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
TthAA220_13060	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TthAA220_13070	ENOG410704R	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA220_13080	ENOG41089ID	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TthAA220_13110	ENOG4105EBX	v-type atpase
TthAA220_13180	ENOG4105E8R	UPF0173 metal-dependent hydrolase
TthAA220_13190	ENOG4108V5V	Serine Threonine protein kinase
TthAA220_13200	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TthAA220_13210	ENOG4105CJR	Integral membrane protein (MviN
TthAA220_13230	ENOG4105EYH	Exonuclease
TthAA220_13280	ENOG4105MS2	ribosomal subunit Interface protein
TthAA220_13290	ENOG4105CAK	Cell division ATP-binding protein ftsE
TthAA220_13300	ENOG4105CN1	protease
TthAA220_13310	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TthAA220_13320	ENOG4105E66	phosphoriboisomerase A
TthAA220_13330	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAA220_13370	ENOG4105UIB	(ABC) transporter
TthAA220_13380	ENOG4105C2J	ABC transporter
TthAA220_13390	ENOG41080QG	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
TthAA220_13410	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TthAA220_13450	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
TthAA220_13460	ENOG4105ESV	Glycosyl transferase, family 4
TthAA220_13470	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
TthAA220_13550	ENOG4105C0H	protease
TthAA220_13560	ENOG4105CIY	formyltetrahydrofolate deformylase
TthAA220_13570	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
TthAA220_13580	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
TthAA220_13590	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TthAA220_13630	ENOG4105CGH	5'-nucleotidase
TthAA220_13640	ENOG4105C5F	glutamine synthetase
TthAA220_13660	ENOG4105C32	Amino acid ABC transporter (Permease)
TthAA220_13670	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TthAA220_13680	ENOG4105C0Z	ABC transporter
TthAA220_13690	ENOG4108IV0	ABC, transporter
TthAA220_13700	ENOG4105DEF	Extracellular solute-binding protein, family 5
TthAA220_13710	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TthAA220_13720	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TthAA220_13740	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TthAA220_13750	ENOG4105BZ1	(ABC) transporter
TthAA220_13760	ENOG4105BZ1	(ABC) transporter
TthAA220_13770	ENOG4105BZN	citrate synthase
TthAA220_13780	ENOG4105D06	uba thif-type nad fad binding protein
TthAA220_13790	ENOG4105DG6	mannose-6-phosphate isomerase
TthAA220_13810	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
TthAA220_13830	ENOG4105K70	DNA-binding protein
TthAA220_13860	ENOG4105WH1	Two component transcriptional regulator luxr family
TthAA220_13870	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TthAA220_13880	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
TthAA220_13890	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TthAA220_13900	ENOG4105VF7	tolerance protein
TthAA220_13910	ENOG4108W63	CRP FNR family transcriptional regulator
TthAA220_13950	ENOG4105BZU	Histidine kinase
TthAA220_13970	ENOG4105D5G	Transposase
TthAA220_13990	ENOG4105DZR	Type I site-specific deoxyribonuclease
TthAA220_14010	ENOG4105D5G	Transposase
TthAA220_14060	ENOG4105D5G	Transposase
TthAA220_14080	ENOG4105CVR	type I restriction-modification system
TthAA220_14090	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
TthAA220_14100	ENOG4107QR9	Iron-sulfur cluster binding protein
TthAA220_14110	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
TthAA220_14120	ENOG4105C3F	Signal peptidase i
TthAA220_14130	ENOG4105D78	K07001 NTE family protein
TthAA220_14140	ENOG4105D9P	serine threonine protein kinase
TthAA220_14150	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
TthAA220_14170	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
TthAA220_14190	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TthAA220_14210	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TthAA220_14270	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
TthAA220_14280	ENOG4107ZC0	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
TthAA220_14290	ENOG4105D49	3-dehydroquinate synthase
TthAA220_14300	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TthAA220_14310	ENOG41084ZW	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
TthAA220_14340	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TthAA220_14350	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TthAA220_14360	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TthAA220_14370	ENOG4107RDB	Major Facilitator
TthAA220_14380	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
TthAA220_14400	ENOG4108AH5	Binds directly to 16S ribosomal RNA (By similarity)
TthAA220_14420	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
TthAA220_14450	ENOG4105KWW	Biogenesis protein
TthAA220_14460	ENOG4107QX9	Thiol disulfide interChange protein
TthAA220_14470	ENOG4105DA4	cytochrome c-type biogenesis protein
TthAA220_14480	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
TthAA220_14490	ENOG41060IM	Heme exporter protein
TthAA220_14500	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
TthAA220_14510	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
TthAA220_14520	ENOG4107QIV	Cytochrome c biogenesis protein
TthAA220_14530	ENOG4105NQN	cytochrome C
TthAA220_14550	ENOG4107S7U	Sulfide dehydrogenase
TthAA220_14580	ENOG4105QN4	diheme cytochrome
TthAA220_14590	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
TthAA220_14600	ENOG4105CGH	5'-nucleotidase
TthAA220_14610	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
TthAA220_14620	ENOG4105QN4	diheme cytochrome
TthAA220_14660	ENOG41067HZ	cytochrome C, class I
TthAA220_14670	ENOG4108UCS	ABC, transporter
TthAA220_14710	ENOG4107QKV	phosphomannomutase
TthAA220_14730	ENOG4105CEY	Amp-dependent synthetase and ligase
TthAA220_14740	ENOG4105WKW	Pfam:DUF1458
TthAA220_14770	ENOG4105E39	Enoyl-CoA hydratase
TthAA220_14780	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
TthAA220_14790	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
TthAA220_14800	ENOG4105IJJ	transcriptional regulator, crp fnr family
TthAA220_14810	ENOG4108N5B	2-phosphosulfolactate phosphatase
TthAA220_14830	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
TthAA220_14850	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
TthAA220_14870	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
TthAA220_14880	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
TthAA220_14890	ENOG4105CBT	Fructose-1,6-bisphosphatase
TthAA220_14900	ENOG4105DCF	alanine dehydrogenase
TthAA220_14910	ENOG4105CYC	Transferase
TthAA220_14920	ENOG4105F8V	Hydrolase, tatD family
TthAA220_14950	ENOG4105C5S	asparaginyl-tRNA synthetase
TthAA220_14980	ENOG4105E33	succinate dehydrogenase
TthAA220_15020	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TthAA220_15040	ENOG4105CIG	ABC transporter
TthAA220_15080	ENOG4105CEY	Amp-dependent synthetase and ligase
TthAA220_15090	ENOG4108UJD	30S ribosomal protein S9
TthAA220_15100	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TthAA220_15110	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TthAA220_15150	ENOG4105CBC	glutamate synthase
TthAA220_15200	ENOG4105D5G	Transposase
TthAA220_15210	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TthAA220_15230	ENOG4105D5G	Transposase
TthAA220_15250	ENOG4105DB1	molybdopterin oxidoreductase
TthAA220_15260	ENOG4106YBV	Methyl-accepting chemotaxis
TthAA220_15270	ENOG4105CDU	Replicative dna helicase
TthAA220_15300	ENOG4105E2M	Manganese-dependent inorganic pyrophosphatase
TthAA220_15330	ENOG4107S91	Sodium hydrogen exchanger
TthAA220_15340	ENOG4105NCW	Trka-c domain protein
TthAA220_15360	ENOG4108ZVP	Domain of unknown function (DUF1931)
TthAA220_15380	ENOG4105K63	Thioredoxin
TthAA220_15400	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAA220_15460	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TthAA220_15470	ENOG4108FYC	transcriptional regulator MERR family
TthAA220_15480	ENOG4105DVC	DnaJ domain protein
TthAA220_15490	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthAA220_15500	ENOG4105CFG	Acts as a chaperone (By similarity)
TthAA220_15510	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TthAA220_15520	ENOG4105DR4	Methyltransferase
TthAA220_15530	ENOG4105D07	Signal peptide peptidase, SppA
TthAA220_15540	ENOG4105VQU	rdd domain containing protein
TthAA220_15560	ENOG4108UKM	mov34 mpn pad-1 family protein
TthAA220_15570	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TthAA220_15580	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TthAA220_15590	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TthAA220_15610	ENOG41062D9	Histidine kinase
TthAA220_15660	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
TthAA220_15680	ENOG4108Z8I	decarboxylase
TthAA220_15740	ENOG4105C83	adenylosuccinate lyase
TthAA220_15770	ENOG4105C8V	SAICAR synthetase
TthAA220_15790	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
TthAA220_15810	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
TthAA220_15830	ENOG4108T9W	RNA methylase
TthAA220_15860	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
TthAA220_15870	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
TthAA220_15880	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
TthAA220_15890	ENOG4105CIS	alcohol dehydrogenase
TthAA220_15930	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
TthAA220_15980	ENOG4105K6V	RNA polymerase
TthAA220_16000	ENOG4108HMX	isocitrate dehydrogenase (NADP)
TthAA220_16020	ENOG4107R08	Integrase
TthAA220_16100	ENOG4108FWV	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
TthAA220_16140	ENOG4105KA0	thioesterase Superfamily protein
TthAA220_16160	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
TthAA220_16170	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TthAA220_16180	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
TthAA220_16190	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
TthAA220_16220	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TthAA220_16240	ENOG41067KJ	GYD family
TthAA220_16250	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
TthAA220_16260	ENOG4105D5G	Transposase
TthAA220_16290	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TthAA220_16300	ENOG4107QX3	carboxylase
TthAA220_16310	ENOG41081FY	multiple antibiotic resistance (MarC)-related
TthAA220_16320	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
TthAA220_16330	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TthAA220_16340	ENOG41079SJ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
TthAA220_16350	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
TthAA220_16370	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
TthAA220_16380	ENOG4105JFG	SpoIID LytB domain protein
TthAA220_16390	ENOG41074B2	UPF0747 protein
TthAA220_16410	ENOG4105E63	Pfam:DUF178
TthAA220_16490	ENOG4105D82	Glutamate dehydrogenase
TthAA220_16500	ENOG4105D82	Glutamate dehydrogenase
TthAA220_16510	ENOG4105C26	Dehydrogenase
TthAA220_16520	ENOG41062BK	proline dehydrogenase
TthAA220_16550	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TthAA220_16560	ENOG4105XEZ	This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the
TthAA220_16580	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TthAA220_16590	ENOG4105CPF	Cell wall formation (By similarity)
TthAA220_16600	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
TthAA220_16610	ENOG4107UH2	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
TthAA220_16640	ENOG4105BZU	Histidine kinase
TthAA220_16650	ENOG4105ETX	regulatoR
TthAA220_16660	ENOG4105D9P	serine threonine protein kinase
TthAA220_16670	ENOG4108ZF3	Phosphatase
TthAA220_16690	ENOG4105C6X	Major Facilitator
TthAA220_16700	ENOG4105D52	delta-aminolevulinic acid dehydratase
TthAA220_16710	ENOG41080DW	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
TthAA220_16720	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
TthAA220_16770	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TthAA220_16780	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
TthAA220_16790	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TthAA220_16830	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
TthAA220_16840	ENOG4105EJU	HAD-superfamily hydrolase subfamily IA variant 3
TthAA220_16890	ENOG4107YU2	histidine triad (hIT) protein
TthAA220_16900	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TthAA220_16910	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
TthAA220_16920	ENOG4105C87	Aminotransferase class I and II
TthAA220_16930	ENOG4105VN1	Heat shock protein
TthAA220_16940	ENOG4105KHC	sulfurtransferase
TthAA220_16950	ENOG4105C5X	domain protein
TthAA220_16970	ENOG4108Z9K	Osmotically inducible protein
TthAA220_17000	ENOG4107QKW	extracellular solute-binding protein family 1
TthAA220_17020	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TthAA220_17030	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TthAA220_17040	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TthAA220_17060	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
TthAA220_17090	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TthAA220_17120	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
TthAA220_17130	ENOG4105BZU	Histidine kinase
TthAA220_17140	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
TthAA220_17150	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
TthAA220_17160	ENOG4108URH	decarboxylase
TthAA220_17170	ENOG4105C98	muts2 protein
TthAA220_17180	ENOG4107R28	alpha amylase, catalytic region
TthAA220_17210	ENOG4105EG2	ABC transporter, permease
TthAA220_17220	ENOG4105D56	permease protein
TthAA220_17250	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TthAA220_17260	ENOG4105EAH	synthase
TthAA220_17350	ENOG4108ZT0	50S ribosomal protein l17
TthAA220_17360	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TthAA220_17370	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TthAA220_17380	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TthAA220_17390	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthAA220_17400	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
TthAA220_17420	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TthAA220_17430	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
TthAA220_17440	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TthAA220_17450	ENOG410856V	50S ribosomal protein L30
TthAA220_17460	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TthAA220_17470	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TthAA220_17480	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TthAA220_17490	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TthAA220_17500	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
TthAA220_17510	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TthAA220_17520	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TthAA220_17530	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TthAA220_17540	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
TthAA220_17550	ENOG4108CHD	50s ribosomal protein l29
TthAA220_17560	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
TthAA220_17570	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
TthAA220_17580	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
TthAA220_17590	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TthAA220_17600	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthAA220_17610	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TthAA220_17620	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
TthAA220_17630	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TthAA220_17640	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TthAA220_17650	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TthAA220_17660	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TthAA220_17670	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TthAA220_17680	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
TthAA220_17760	ENOG4105PW4	Sugar fermentation stimulation protein homolog
TthAA220_17830	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
TthAA220_17840	ENOG4107T9V	chlorite dismutase
TthAA220_17850	ENOG4105D8X	mechanosensitive ion channel
TthAA220_17870	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
TthAA220_17880	ENOG4105C59	p-type ATPase
TthAA220_17940	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TthAA220_17950	ENOG4105EB3	Histidine kinase
TthAA220_18000	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TthAA220_18040	ENOG4107STQ	Multicopper oxidase
TthAA220_18060	ENOG4105C9B	Cysteine desulfurase
TthAA220_18070	ENOG4108UNV	SUF system FeS assembly protein, NifU family
TthAA220_18090	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
TthAA220_18110	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
TthAA220_18130	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TthAA220_18140	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
TthAA220_18160	ENOG4107YEI	lmbE family
TthAA220_18180	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
TthAA220_18190	ENOG4105K63	Thioredoxin
TthAA220_18200	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TthAA220_18210	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthAA220_18230	ENOG4105CPK	Glycosyl transferase (Group 1
TthAA220_18260	ENOG4105C8Y	Acetylornithine aminotransferase
TthAA220_18270	ENOG4108KB0	deacetylase
TthAA220_18280	ENOG4105BZU	Histidine kinase
TthAA220_18350	ENOG4107SFQ	iron-sulfur binding
TthAA220_18380	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
TthAA220_18390	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
TthAA220_18450	ENOG4105CZX	twitching motility protein
TthAA220_18460	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
TthAA220_18510	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
TthAA220_18520	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthAA220_18530	ENOG4105K46	50S ribosomal protein l27
TthAA220_18540	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
TthAA220_18560	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TthAA220_18620	ENOG4105D5G	Transposase
TthAA220_18730	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TthAA220_18740	ENOG4107ZT3	family UPF0126
TthAA220_18760	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
TthAA220_18790	ENOG4105CBP	Major Facilitator
TthAA220_18800	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
TthAA220_18810	ENOG4108Z5K	methylglyoxal synthase
TthAA220_18830	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TthAA220_18840	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TthAA220_18850	ENOG4105F4P	)-transporter
TthAA220_18880	ENOG41090A4	Pterin carbinolamine dehydratase
TthAA220_18910	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
TthAA220_18920	ENOG4105E0C	molybdate abc transporter
TthAA220_18930	ENOG4105C4Y	ABC transporter
TthAA220_18960	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
TthAA220_18970	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TthAA220_18980	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TthAA220_19000	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
TthAA220_19010	ENOG4105DFF	Rod shape-determining protein mreb
TthAA220_19020	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
TthAA220_19030	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TthAA220_19040	ENOG4108784	2'-5' rna ligase
TthAA220_19050	ENOG4105CEV	competence damage-inducible protein
TthAA220_19060	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
TthAA220_19090	ENOG4105DTQ	mandelate racemase muconate lactonizing
TthAA220_19120	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
TthAA220_19140	ENOG4106B0N	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
TthAA220_19160	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TthAA220_19180	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TthAA220_19190	ENOG4108I0Y	(ABC) transporter
TthAA220_19200	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TthAA220_19230	ENOG4105C3K	feS assembly ATPase SufC
TthAA220_19240	ENOG4105DIW	FeS assembly protein SUFB
TthAA220_19260	ENOG4105VQD	rieske 2fe-2S domain-containing protein
TthAA220_19270	ENOG4107QYG	anthranilate phosphoribosyltransferase
TthAA220_19280	ENOG4105DDQ	anthranilate synthase
TthAA220_19290	ENOG4105CRQ	synthase (Component I)
TthAA220_19360	ENOG4108UXE	Protein tyrosine phosphatase
TthAA220_19370	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TthAA220_19380	ENOG4105UIB	(ABC) transporter
TthAA220_19420	ENOG4105MA4	psp1 domain protein
TthAA220_19430	ENOG4107QRG	dna polymerase iii
TthAA220_19500	ENOG4105C22	threonyL-tRNA synthetase
TthAA220_19510	ENOG4105EUJ	GTP cyclohydrolase i
TthAA220_19520	ENOG4108Z0R	Transferase
TthAA220_19530	ENOG41062IR	nudix hydrolase
TthAA220_19560	ENOG4105D1H	recombination factor protein RarA
TthAA220_19580	ENOG4105DRS	transport system, permease
TthAA220_19590	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
TthAA220_19600	ENOG4105CJ1	ABC, transporter
TthAA220_19650	ENOG4105C7S	Dehydrogenase
TthAA220_19660	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TthAA220_19670	ENOG4105ZU5	s-layer protein
TthAA220_19680	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TthAA220_19690	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TthAA220_19720	ENOG4105C4K	Nad synthetase
TthAA220_19740	ENOG4107RFW	hydrolase family 57
TthAA220_19750	ENOG4107U4Q	acetylglutamate kinase
TthAA220_19760	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TthAA220_19770	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
TthAA220_19780	ENOG4106928	lysine biosynthesis protein LysW
TthAA220_19800	ENOG4108S93	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TthAA220_19810	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TthAA220_19840	ENOG4108JZA	Homocitrate synthase
TthAA220_19850	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TthAA220_19860	ENOG4105C1G	acyl-Coa dehydrogenase
TthAA220_19870	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TthAA220_19890	ENOG4105C3M	thioredoxin reductase
TthAA220_19940	ENOG4108WBT	adenosyltransferase
TthAA220_19970	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TthAA220_19980	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
TthAA220_20000	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
TthAA220_20010	ENOG4107EUI	c reductase, iron-sulfur
TthAA220_20030	ENOG41067HZ	cytochrome C, class I
TthAA220_20050	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
TthAA220_20060	ENOG4105BZ7	extracellular solute-binding protein family 1
TthAA220_20070	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
TthAA220_20080	ENOG4105C1G	acyl-Coa dehydrogenase
TthAA220_20100	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
TthAA220_20160	ENOG4105CJ1	ABC, transporter
TthAA220_20210	ENOG4105DXN	mazG family
TthAA220_20230	ENOG4107R7Y	intracellular protease Pfpi family
TthAA220_20240	ENOG4107RRU	Involved in both the arginine and lysine biosynthetic pathways (By similarity)
TthAA220_20260	ENOG4105C6E	dna polymerase iii
TthAA220_20270	ENOG4105VPX	protein, conserved in bacteria
TthAA220_20290	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TthAA220_20300	ENOG4105DQU	oxidoreductase, subunit beta
TthAA220_20310	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
TthAA220_20320	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
TthAA220_20330	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
TthAA220_20350	ENOG4105CTQ	phosphohexokinase
TthAA220_20380	ENOG4105F0N	pyrophosphate phospho-hydrolase
TthAA220_20410	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
TthAA220_20420	ENOG4105FA0	parb-like partition protein
TthAA220_20430	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
TthAA220_20440	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
TthAA220_20450	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TthAA220_20480	ENOG4105CT4	transporter
TthAA220_20550	ENOG4105DR5	peptidase
TthAA220_20670	ENOG4105KRG	Aromatic-ring-hydroxylating dioxygenase beta subunit
TthAA220_20680	ENOG4105FUY	alpha subunit
TthAA220_20700	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
TthAA220_20720	ENOG4105ETE	Transcriptional regulator (LacI family
TthAA220_20750	ENOG4107YVC	modification (methylase)
TthAA220_20800	ENOG41060M0	Crispr-associated protein, cse4 family
TthAA220_20840	ENOG4105PWE	CRISPR-associated protein cas2
TthAA220_20850	ENOG4105E7W	lamb ycsf family protein
TthAA220_20870	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TthAA220_20900	ENOG4107UWC	ABC, transporter
TthAA220_20910	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
TthAA220_20940	ENOG4106IPI	cyclase, family
TthAA220_20950	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
TthAA220_20960	ENOG4107QKC	Oxidoreductase alpha (molybdopterin) subunit
TthAA220_20990	ENOG4105D5G	Transposase
TthAA220_21020	ENOG41067HZ	cytochrome C, class I
TthAA220_21100	ENOG4105EB3	Histidine kinase
TthAA220_21110	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TthAA220_21120	ENOG41067HZ	cytochrome C, class I
TthAA220_21190	ENOG4105C0H	protease
TthAA220_21210	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
TthAA220_21220	ENOG4108J5G	6-phosphogluconate dehydrogenase
TthAA220_21230	ENOG4107XU2	6-phosphogluconolactonase (EC 3.1.1.31)
TthAA220_21320	ENOG410841Q	phosphoesterase PA-phosphatase related protein
TthAA220_21330	ENOG4105ETX	regulatoR
TthAA220_21340	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
TthAA220_21350	ENOG4105DHQ	Histidine kinase
TthAA220_21360	ENOG4107YEI	lmbE family
TthAA220_21380	ENOG4105C56	H( )-stimulated, divalent metal cation uptake system (By similarity)
TthAA220_21420	ENOG4106EQQ	Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity)
TthAA220_21580	ENOG4105ETX	regulatoR
TthAA220_21590	ENOG41062D9	Histidine kinase
TthAA220_21720	ENOG41084KP	4-oxalocrotonate tautomerase
TthAA220_21740	ENOG4106KE4	Dehydrogenase
TthAA220_21800	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TthAA220_21830	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
TthAA220_21870	ENOG41067HZ	cytochrome C, class I
TthAA220_21890	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
TthAA220_21910	ENOG4105CE1	Ferrous iron transport protein b
TthAA220_21930	ENOG4105CE1	Ferrous iron transport protein b
TthAA220_21970	ENOG4105E33	succinate dehydrogenase
TthAA220_21990	ENOG4108Z4U	Ferredoxin
TthAA220_22070	ENOG4105D5G	Transposase
TthAA220_22120	ENOG4107V8H	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
TthAA220_22160	ENOG41067HZ	cytochrome C, class I
TthAA220_22170	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TthAA220_22180	ENOG4105F64	nitrite reductase
TthAA220_22210	ENOG4108VKQ	nitriC oxide reductase
TthAA220_22280	ENOG4107QIW	Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity)
TthAA220_22300	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
TthAA220_22310	ENOG4105FA0	parb-like partition protein
TthAA220_22330	ENOG4105FA0	parb-like partition protein
TthAA220_22400	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
TthAA220_22410	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
TthAA220_22470	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
TthAA220_22560	ENOG4105FE1	phytoene synthase
TthAA220_22580	ENOG41090K0	Transcriptional regulator, Crp Fnr family
TthAA220_22600	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
TthAA220_22630	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
TthAA220_22660	ENOG4105CHR	reductase
TthAA220_22670	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TthAA220_22690	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
TthAA220_22700	ENOG4108UHU	Aldolase
TthAA220_22760	ENOG4105CE4	GlcNAc 6-P deacetylase
TthAA220_22770	ENOG4105G6Z	alkaline phosphatase
TthAA220_22780	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TthAA220_22840	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
TthAA220_22850	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
TthAA220_22860	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TthAA220_22880	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
TthAA220_22890	ENOG4108P62	biosynthesis protein (CbiG)
TthAA220_22900	ENOG4105E4R	Precorrin-3B C17-methyltransferase
TthAA220_22910	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
TthAA220_22920	ENOG4105DVK	Precorrin-2 c20-methyltransferase
TthAA220_22930	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
TthAA220_22940	ENOG41081F0	Precorrin-8x methylmutase
TthAA220_22950	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
TthAA220_22960	ENOG4105D9G	High-affinity
TthAA220_22970	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TthAA220_23000	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
TthAA220_23020	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
TthAA220_23030	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TthAA220_t00340	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation