locus-tag	class	description
TthAA220_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthAA220_00020	COG0592	DNA-directed DNA polymerase activity
TthAA220_00030	COG0148	phosphopyruvate hydratase activity
TthAA220_00040	COG0469	pyruvate kinase activity
TthAA220_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA220_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthAA220_00090	COG1842	Phage shock protein A
TthAA220_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthAA220_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA220_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthAA220_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthAA220_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA220_00200	COG1278	Cold shock
TthAA220_00210	COG1653	transport
TthAA220_00240	COG0033	Phosphoglucomutase
TthAA220_00260	COG0477	Major facilitator Superfamily
TthAA220_00280	COG0517	IMP dehydrogenase activity
TthAA220_00280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthAA220_00290	COG1950	PFAM Membrane protein of
TthAA220_00300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthAA220_00310	COG1047	Peptidyl-prolyl cis-trans
TthAA220_00320	COG0181	hydroxymethylbilane synthase activity
TthAA220_00340	COG0285	dihydrofolate synthase activity
TthAA220_00350	COG0436	Aminotransferase
TthAA220_00360	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthAA220_00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthAA220_00420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthAA220_00430	COG1993	acr, cog1993
TthAA220_00440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthAA220_00460	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA220_00480	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthAA220_00490	COG1335	isochorismatase
TthAA220_00500	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthAA220_00530	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthAA220_00540	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthAA220_00560	COG0242	peptide deformylase activity
TthAA220_00570	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TthAA220_00580	COG1660	Displays ATPase and GTPase activities
TthAA220_00590	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthAA220_00680	COG3335	DDE superfamily endonuclease
TthAA220_00700	COG1845	cytochrome c oxidase, subunit III
TthAA220_00700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA220_00720	COG0109	protoheme IX farnesyltransferase activity
TthAA220_00720	COG1612	heme a metabolic process
TthAA220_00750	COG0343	queuine tRNA-ribosyltransferase activity
TthAA220_00760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthAA220_00770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthAA220_00900	COG1940	carbohydrate kinase activity
TthAA220_00920	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA220_00930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA220_00940	COG0589	response to stress
TthAA220_00950	COG1611	Belongs to the LOG family
TthAA220_00970	COG1011	Hydrolase
TthAA220_00980	COG0632	four-way junction helicase activity
TthAA220_00990	COG1024	Enoyl-CoA hydratase
TthAA220_01010	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA220_01030	COG0137	argininosuccinate synthase activity
TthAA220_01040	COG0165	Argininosuccinate lyase
TthAA220_01080	COG0505	Belongs to the CarA family
TthAA220_01100	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthAA220_01110	COG0166	Belongs to the GPI family
TthAA220_01130	COG0714	Associated with various cellular activities
TthAA220_01160	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA220_01170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthAA220_01180	COG0459	protein refolding
TthAA220_01190	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthAA220_01200	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthAA220_01220	COG0778	Nitroreductase
TthAA220_01230	COG1388	LysM domain
TthAA220_01230	COG0791	NLP P60 protein
TthAA220_01250	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthAA220_01270	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthAA220_01280	COG0581	inorganic phosphate transmembrane transporter activity
TthAA220_01290	COG0573	inorganic phosphate transmembrane transporter activity
TthAA220_01310	COG0482	sulfurtransferase activity
TthAA220_01330	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthAA220_01340	COG0735	belongs to the Fur family
TthAA220_01370	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthAA220_01380	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA220_01390	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthAA220_01400	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthAA220_01410	COG0250	Participates in transcription elongation, termination and antitermination
TthAA220_01420	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TthAA220_01430	COG0081	regulation of translation
TthAA220_01440	COG0360	Binds together with S18 to 16S ribosomal RNA
TthAA220_01450	COG0629	single-stranded DNA binding
TthAA220_01460	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthAA220_01470	COG0359	binds to the 23S rRNA
TthAA220_01510	COG0300	oxidoreductase activity
TthAA220_01520	COG0321	lipoyl(octanoyl) transferase activity
TthAA220_01530	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthAA220_01580	COG1476	TRANSCRIPTIONal
TthAA220_01620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthAA220_01650	COG1598	PFAM Uncharacterised protein family UPF0150
TthAA220_01660	COG0022	dehydrogenase e1 component
TthAA220_01670	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthAA220_01680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthAA220_01730	COG2226	methyltransferase
TthAA220_01740	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthAA220_01770	COG1187	pseudouridine synthase activity
TthAA220_01790	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthAA220_01800	COG0686	Belongs to the AlaDH PNT family
TthAA220_01820	COG1461	Dihydroxyacetone kinase
TthAA220_01850	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthAA220_01860	COG0222	ribosome binding
TthAA220_01870	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthAA220_01880	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TthAA220_01890	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthAA220_01900	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthAA220_01920	COG0697	spore germination
TthAA220_01950	COG3177	Filamentation induced by cAMP protein fic
TthAA220_01970	COG0243	molybdopterin cofactor binding
TthAA220_01990	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthAA220_02010	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA220_02040	COG0477	Major facilitator Superfamily
TthAA220_02070	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthAA220_02090	COG0105	UTP biosynthetic process
TthAA220_02100	COG0631	protein serine/threonine phosphatase activity
TthAA220_02110	COG0583	DNA-binding transcription factor activity
TthAA220_02130	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA220_02190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA220_02210	COG1278	Cold shock
TthAA220_02220	COG0484	heat shock protein binding
TthAA220_02230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthAA220_02240	COG1968	undecaprenyl-diphosphatase activity
TthAA220_02250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthAA220_02260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthAA220_02290	COG1309	transcriptional regulator
TthAA220_02300	COG4242	Belongs to the peptidase S51 family
TthAA220_02330	COG0802	atpase or kinase
TthAA220_02340	COG0539	negative regulation of cytoplasmic translation
TthAA220_02350	COG0495	leucyl-tRNA aminoacylation
TthAA220_02390	COG1902	pentaerythritol trinitrate reductase activity
TthAA220_02440	COG2414	aldehyde ferredoxin oxidoreductase
TthAA220_02460	COG4968	Prepilin-type N-terminal cleavage methylation domain
TthAA220_02480	COG2165	general secretion pathway protein
TthAA220_02540	COG1459	type II secretion system
TthAA220_02560	COG1187	pseudouridine synthase activity
TthAA220_02580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA220_02590	COG0745	RESPONSE REGULATOR receiver
TthAA220_02600	COG4191	Histidine kinase
TthAA220_02610	COG0704	Plays a role in the regulation of phosphate uptake
TthAA220_02620	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthAA220_02640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthAA220_02660	COG0515	serine threonine protein kinase
TthAA220_02660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthAA220_02720	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthAA220_02730	COG4221	oxidoreductase activity
TthAA220_02760	COG0717	Belongs to the dCTP deaminase family
TthAA220_02770	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthAA220_02780	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthAA220_02790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA220_02830	COG0583	DNA-binding transcription factor activity
TthAA220_02840	COG3546	catalase activity
TthAA220_02850	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA220_02850	COG0758	DNA mediated transformation
TthAA220_02860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthAA220_02880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA220_02900	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthAA220_02920	COG0442	prolyl-tRNA aminoacylation
TthAA220_02930	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthAA220_02970	COG0303	'Molybdopterin
TthAA220_02980	COG0513	Belongs to the DEAD box helicase family
TthAA220_02990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthAA220_03010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthAA220_03050	COG2070	2-Nitropropane dioxygenase
TthAA220_03080	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthAA220_03100	COG0018	arginyl-trna synthetase
TthAA220_03110	COG1007	ATP synthesis coupled electron transport
TthAA220_03120	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA220_03130	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthAA220_03140	COG0713	ATP synthesis coupled electron transport
TthAA220_03150	COG0839	Belongs to the complex I subunit 6 family
TthAA220_03160	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA220_03170	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthAA220_03180	COG1034	ATP synthesis coupled electron transport
TthAA220_03190	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthAA220_03200	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthAA220_03210	COG0649	NAD binding
TthAA220_03220	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA220_03230	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA220_03240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA220_03250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthAA220_03270	COG4712	double-strand break repair protein
TthAA220_03360	COG0135	phosphoribosylanthranilate isomerase activity
TthAA220_03380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthAA220_03400	COG2720	vancomycin resistance protein
TthAA220_03470	COG0277	FAD linked oxidase domain protein
TthAA220_03500	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthAA220_03510	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthAA220_03540	COG0314	molybdopterin synthase activity
TthAA220_03550	COG1420	regulation of RNA biosynthetic process
TthAA220_03560	COG0347	Belongs to the P(II) protein family
TthAA220_03570	COG0004	ammonium transporteR
TthAA220_03590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthAA220_03610	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA220_03640	COG1597	lipid kinase activity
TthAA220_03670	COG0475	glutathione-regulated potassium exporter activity
TthAA220_03670	COG0569	domain protein
TthAA220_03690	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthAA220_03710	COG0277	FAD linked oxidase domain protein
TthAA220_03760	COG0667	Aldo Keto reductase
TthAA220_03820	COG1067	ATP-dependent peptidase activity
TthAA220_03830	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthAA220_03850	COG0745	RESPONSE REGULATOR receiver
TthAA220_03860	COG2105	PFAM AIG2 family protein
TthAA220_03870	COG0297	glycogen (starch) synthase activity
TthAA220_03890	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthAA220_03900	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthAA220_03930	COG0142	geranyltranstransferase activity
TthAA220_03950	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthAA220_03960	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA220_03970	COG0492	ferredoxin-NADP+ reductase activity
TthAA220_03990	COG0792	nuclease activity
TthAA220_04000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthAA220_04030	COG1175	transmembrane transport
TthAA220_04040	COG0395	ABC-type sugar transport system, permease component
TthAA220_04100	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthAA220_04110	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthAA220_04120	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthAA220_04130	COG0805	protein transport
TthAA220_04140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA220_04140	COG1605	Chorismate mutase
TthAA220_04200	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA220_04260	COG1063	alcohol dehydrogenase
TthAA220_04320	COG2255	four-way junction helicase activity
TthAA220_04330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthAA220_04340	COG0564	pseudouridine synthase activity
TthAA220_04370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthAA220_04380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthAA220_04390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthAA220_04400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthAA220_04420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthAA220_04430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthAA220_04440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthAA220_04520	COG0778	Nitroreductase
TthAA220_04550	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthAA220_04560	COG0131	Imidazoleglycerol-phosphate dehydratase
TthAA220_04570	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthAA220_04580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAA220_04590	COG0516	GMP reductase activity
TthAA220_04590	COG0517	IMP dehydrogenase activity
TthAA220_04620	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthAA220_04630	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA220_04660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA220_04700	COG0706	membrane insertase activity
TthAA220_04710	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthAA220_04720	COG0594	ribonuclease P activity
TthAA220_04740	COG1022	Amp-dependent synthetase and ligase
TthAA220_04750	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA220_04790	COG1121	(ABC) transporter
TthAA220_04800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthAA220_04810	COG1959	2 iron, 2 sulfur cluster binding
TthAA220_04820	COG1104	cysteine desulfurase activity
TthAA220_04830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthAA220_04840	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthAA220_04870	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA220_04910	COG0492	ferredoxin-NADP+ reductase activity
TthAA220_04940	COG0747	negative chemotaxis
TthAA220_04950	COG0601	transmembrane transport
TthAA220_04960	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA220_04990	COG0517	IMP dehydrogenase activity
TthAA220_05000	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA220_05010	COG2104	thiamine diphosphate biosynthetic process
TthAA220_05020	COG0037	tRNA processing
TthAA220_05050	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthAA220_05100	COG4176	ABC-type proline glycine betaine transport system permease component
TthAA220_05110	COG3448	diguanylate cyclase activity
TthAA220_05110	COG4175	Glycine betaine
TthAA220_05120	COG0366	Alpha amylase catalytic
TthAA220_05130	COG2226	methyltransferase
TthAA220_05140	COG2226	methyltransferase
TthAA220_05150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthAA220_05170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthAA220_05180	COG0460	homoserine dehydrogenase
TthAA220_05200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthAA220_05270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthAA220_05310	COG0247	lactate metabolic process
TthAA220_05320	COG0277	FAD linked oxidase domain protein
TthAA220_05330	COG0277	FAD linked oxidase domain protein
TthAA220_05350	COG1414	Transcriptional regulator
TthAA220_05360	COG0789	Transcriptional regulator
TthAA220_05370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA220_05380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA220_05390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA220_05460	COG0861	Integral membrane protein TerC family
TthAA220_05470	COG2151	metal-sulfur cluster biosynthetic enzyme
TthAA220_05480	COG0281	malic enzyme
TthAA220_05510	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthAA220_05520	COG0509	glycine decarboxylation via glycine cleavage system
TthAA220_05530	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA220_05540	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA220_05550	COG0196	riboflavin kinase activity
TthAA220_05560	COG0494	nUDIX hydrolase
TthAA220_05600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthAA220_05610	COG2813	Specifically methylates the guanine in position
TthAA220_05620	COG0527	aspartate kinase activity
TthAA220_05640	COG0039	L-malate dehydrogenase activity
TthAA220_05680	COG4956	integral membrane protein (PIN domain superfamily)
TthAA220_05690	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthAA220_05700	COG0542	response to heat
TthAA220_05710	COG0423	glycine-tRNA ligase activity
TthAA220_05730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthAA220_05770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA220_05770	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA220_05790	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthAA220_05800	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TthAA220_05810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthAA220_05830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA220_05840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA220_05850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthAA220_05860	COG0114	fumarate hydratase activity
TthAA220_05870	COG0183	Belongs to the thiolase family
TthAA220_05900	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthAA220_05910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthAA220_05940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthAA220_05950	COG1254	Belongs to the acylphosphatase family
TthAA220_05980	COG1063	alcohol dehydrogenase
TthAA220_06000	COG2133	pyrroloquinoline quinone binding
TthAA220_06020	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthAA220_06030	COG0154	amidase activity
TthAA220_06080	COG0572	uridine kinase
TthAA220_06090	COG3842	ATPase activity
TthAA220_06120	COG4475	Protein of unknown function (DUF436)
TthAA220_06160	COG1595	DNA-templated transcription, initiation
TthAA220_06230	COG0410	ABC transporter
TthAA220_06250	COG0683	leucine binding
TthAA220_06300	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA220_06310	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthAA220_06320	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthAA220_06360	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthAA220_06370	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthAA220_06380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthAA220_06400	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA220_06410	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA220_06420	COG1012	belongs to the aldehyde dehydrogenase family
TthAA220_06420	COG2030	dehydratase
TthAA220_06430	COG1960	acyl-CoA dehydrogenase activity
TthAA220_06460	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthAA220_06480	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthAA220_06500	COG3870	Protein conserved in bacteria
TthAA220_06510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthAA220_06530	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthAA220_06540	COG0740	serine-type endopeptidase activity
TthAA220_06550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthAA220_06560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthAA220_06570	COG1410	methionine synthase
TthAA220_06570	COG0646	methionine synthase
TthAA220_06580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA220_06600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthAA220_06630	COG1692	metallophosphoesterase
TthAA220_06640	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthAA220_06670	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthAA220_06680	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthAA220_06810	COG0438	transferase activity, transferring glycosyl groups
TthAA220_06860	COG0529	Catalyzes the synthesis of activated sulfate
TthAA220_06870	COG2046	Belongs to the sulfate adenylyltransferase family
TthAA220_06900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA220_06940	COG0489	protein tyrosine kinase activity
TthAA220_06960	COG2264	protein methyltransferase activity
TthAA220_06970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthAA220_07030	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAA220_07030	COG0574	Belongs to the PEP-utilizing enzyme family
TthAA220_07050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthAA220_07060	COG2046	Belongs to the sulfate adenylyltransferase family
TthAA220_07070	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA220_07070	COG1648	precorrin-2 dehydrogenase activity
TthAA220_07080	COG0730	response to heat
TthAA220_07090	COG0175	sulfate reduction
TthAA220_07100	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA220_07100	COG1648	precorrin-2 dehydrogenase activity
TthAA220_07110	COG1587	Uroporphyrinogen-III synthase
TthAA220_07120	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthAA220_07140	COG0352	thiamine-phosphate diphosphorylase activity
TthAA220_07150	COG2104	thiamine diphosphate biosynthetic process
TthAA220_07160	COG2022	thiamine diphosphate biosynthetic process
TthAA220_07170	COG2022	thiamine diphosphate biosynthetic process
TthAA220_07170	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA220_07180	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthAA220_07190	COG0477	Major facilitator Superfamily
TthAA220_07200	COG0352	thiamine-phosphate diphosphorylase activity
TthAA220_07200	COG0351	phosphomethylpyrimidine kinase
TthAA220_07280	COG1940	carbohydrate kinase activity
TthAA220_07290	COG0183	Belongs to the thiolase family
TthAA220_07320	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA220_07330	COG0410	ABC transporter
TthAA220_07360	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA220_07390	COG2030	dehydratase
TthAA220_07410	COG0596	Alpha beta hydrolase
TthAA220_07420	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA220_07450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA220_07450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA220_07470	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthAA220_07490	COG0195	Participates in both transcription termination and antitermination
TthAA220_07500	COG0779	Required for maturation of 30S ribosomal subunits
TthAA220_07510	COG0739	heme binding
TthAA220_07520	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthAA220_07530	COG0640	Transcriptional regulator
TthAA220_07540	COG2217	Heavy metal translocating P-type atpase
TthAA220_07550	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthAA220_07560	COG0017	Asparaginyl-tRNA synthetase
TthAA220_07570	COG0561	phosphatase activity
TthAA220_07580	COG0384	phenazine biosynthesis protein PhzF
TthAA220_07590	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TthAA220_07600	COG0124	histidyl-tRNA synthetase
TthAA220_07620	COG3842	ATPase activity
TthAA220_07660	COG1573	uracil-dna glycosylase
TthAA220_07700	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthAA220_07710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAA220_07710	COG0519	Catalyzes the synthesis of GMP from XMP
TthAA220_07730	COG1316	TRANSCRIPTIONal
TthAA220_07740	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthAA220_07830	COG0295	cytidine deaminase activity
TthAA220_07870	COG1760	l-serine dehydratase
TthAA220_07890	COG0481	GTPase activity
TthAA220_07910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthAA220_07920	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthAA220_07940	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA220_07990	COG0405	Gamma-glutamyltransferase
TthAA220_08010	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthAA220_08020	COG2873	o-acetylhomoserine
TthAA220_08050	COG1063	alcohol dehydrogenase
TthAA220_08070	COG3191	aminopeptidase activity
TthAA220_08080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA220_08100	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA220_08110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA220_08120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA220_08130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAA220_08140	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TthAA220_08150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthAA220_08170	COG0167	dihydroorotate dehydrogenase activity
TthAA220_08250	COG0730	response to heat
TthAA220_08260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthAA220_08300	COG1960	acyl-CoA dehydrogenase activity
TthAA220_08310	COG0456	acetyltransferase
TthAA220_08330	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthAA220_08340	COG0009	L-threonylcarbamoyladenylate synthase
TthAA220_08380	COG0277	FAD linked oxidase domain protein
TthAA220_08400	COG0287	Prephenate dehydrogenase
TthAA220_08410	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA220_08420	COG2514	catechol 2,3-dioxygenase activity
TthAA220_08430	COG2353	YceI-like domain
TthAA220_08440	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA220_08450	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA220_08490	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA220_08500	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthAA220_08520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthAA220_08530	COG0151	Belongs to the GarS family
TthAA220_08540	COG2176	DNA-directed DNA polymerase activity
TthAA220_08540	COG5002	protein histidine kinase activity
TthAA220_08600	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthAA220_08620	COG0217	transcriptional regulatory protein
TthAA220_08630	COG4651	solute:proton antiporter activity
TthAA220_08630	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthAA220_08640	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthAA220_08650	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthAA220_08660	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA220_08670	COG1674	ftsk spoiiie
TthAA220_08700	COG0517	IMP dehydrogenase activity
TthAA220_08740	COG1994	Peptidase M50
TthAA220_08750	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthAA220_08770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA220_08800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA220_08810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA220_08820	COG2719	SpoVR family
TthAA220_08830	COG2718	Belongs to the UPF0229 family
TthAA220_08840	COG2766	serine protein kinase
TthAA220_08890	COG2137	regulation of response to DNA damage stimulus
TthAA220_08910	COG2359	stage V sporulation protein S
TthAA220_08920	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA220_08930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthAA220_08950	COG0463	Glycosyl transferase, family 2
TthAA220_08960	COG0750	zinc metalloprotease
TthAA220_08970	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthAA220_08980	COG0575	Belongs to the CDS family
TthAA220_08990	COG0233	cytoplasmic translational termination
TthAA220_09000	COG0528	UMP kinase activity
TthAA220_09010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthAA220_09020	COG0052	Belongs to the universal ribosomal protein uS2 family
TthAA220_09040	COG0494	nUDIX hydrolase
TthAA220_09100	COG0402	S-adenosylhomocysteine deaminase activity
TthAA220_09120	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA220_09130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthAA220_09140	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA220_09150	COG1811	Na channel or pump
TthAA220_09160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA220_09160	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthAA220_09190	COG1215	transferase activity, transferring glycosyl groups
TthAA220_09210	COG1215	transferase activity, transferring glycosyl groups
TthAA220_09230	COG0438	transferase activity, transferring glycosyl groups
TthAA220_09240	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthAA220_09270	COG1024	Enoyl-CoA hydratase
TthAA220_09270	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA220_09280	COG0183	Belongs to the thiolase family
TthAA220_09290	COG1960	acyl-CoA dehydrogenase activity
TthAA220_09300	COG0215	cysteine-tRNA ligase activity
TthAA220_09310	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthAA220_09370	COG1196	nuclear chromosome segregation
TthAA220_09400	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthAA220_09410	COG3153	acetyltransferase
TthAA220_09410	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA220_09420	COG1268	BioY protein
TthAA220_09440	COG0126	phosphoglycerate kinase activity
TthAA220_09450	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthAA220_09460	COG0824	Thioesterase
TthAA220_09480	COG0557	exoribonuclease II activity
TthAA220_09490	COG1355	regulation of microtubule-based process
TthAA220_09500	COG0617	tRNA 3'-terminal CCA addition
TthAA220_09510	COG0237	dephospho-CoA kinase activity
TthAA220_09520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA220_09530	COG0742	ribosomal rna small subunit methyltransferase
TthAA220_09540	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthAA220_09550	COG0138	bifunctional purine biosynthesis protein purh
TthAA220_09560	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthAA220_09590	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthAA220_09700	COG0149	triose-phosphate isomerase activity
TthAA220_09710	COG3239	Fatty acid desaturase
TthAA220_09740	COG1490	D-aminoacyl-tRNA deacylase activity
TthAA220_09750	COG1307	EDD domain protein, DegV family
TthAA220_09760	COG1307	EDD domain protein, DegV family
TthAA220_09770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthAA220_09780	COG1510	regulation of RNA biosynthetic process
TthAA220_09820	COG1136	(ABC) transporter
TthAA220_09850	COG3769	mannosylglycerate metabolic process
TthAA220_09870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthAA220_09890	COG1012	belongs to the aldehyde dehydrogenase family
TthAA220_09900	COG2368	4-hydroxyphenylacetate
TthAA220_09910	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthAA220_09940	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA220_09950	COG0411	ABC transporter
TthAA220_09960	COG0410	ABC transporter
TthAA220_09970	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA220_09980	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA220_10000	COG1012	belongs to the aldehyde dehydrogenase family
TthAA220_10000	COG2030	dehydratase
TthAA220_10040	COG3396	Phenylacetate-CoA oxygenase
TthAA220_10060	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthAA220_10120	COG1980	fructose-bisphosphate aldolase activity
TthAA220_10130	COG1733	regulation of RNA biosynthetic process
TthAA220_10140	COG2193	ferroxidase activity
TthAA220_10150	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthAA220_10160	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthAA220_10180	COG1331	Highly conserved protein containing a thioredoxin domain
TthAA220_10190	COG0183	Belongs to the thiolase family
TthAA220_10200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthAA220_10210	COG0477	Major facilitator Superfamily
TthAA220_10250	COG3706	GGDEF domain
TthAA220_10300	COG1012	belongs to the aldehyde dehydrogenase family
TthAA220_10320	COG0248	Ppx GppA phosphatase
TthAA220_10330	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthAA220_10340	COG0210	DNA helicase
TthAA220_10370	COG1309	transcriptional regulator
TthAA220_10380	COG1131	(ABC) transporter
TthAA220_10390	COG0842	Transport permease protein
TthAA220_10460	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA220_10510	COG0582	viral genome integration into host DNA
TthAA220_10520	COG2897	thiosulfate sulfurtransferase activity
TthAA220_10530	COG1760	l-serine dehydratase
TthAA220_10540	COG2197	response regulator
TthAA220_10550	COG0335	large ribosomal subunit rRNA binding
TthAA220_10560	COG0336	Belongs to the RNA methyltransferase TrmD family
TthAA220_10570	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthAA220_10580	COG1837	Belongs to the UPF0109 family
TthAA220_10590	COG0228	four-way junction DNA binding
TthAA220_10620	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA220_10640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthAA220_10650	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TthAA220_10660	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthAA220_10680	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthAA220_10690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthAA220_10700	COG1702	phosphate starvation-inducible protein PhoH
TthAA220_10720	COG4864	UPF0365 protein
TthAA220_10740	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthAA220_10760	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA220_10760	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA220_10770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA220_10790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthAA220_10800	COG1397	ADP-ribosylglycohydrolase
TthAA220_10810	COG2239	Acts as a magnesium transporter
TthAA220_10820	COG2304	oxidoreductase activity
TthAA220_10830	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA220_10830	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA220_10850	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA220_10850	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA220_10860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthAA220_10870	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthAA220_10880	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthAA220_10890	COG0006	proline dipeptidase activity
TthAA220_10910	COG0739	heme binding
TthAA220_10930	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthAA220_10940	COG0254	rRNA binding
TthAA220_10960	COG2001	Belongs to the MraZ family
TthAA220_10970	COG0275	rRNA processing
TthAA220_11000	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthAA220_11020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA220_11030	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthAA220_11040	COG0772	Belongs to the SEDS family
TthAA220_11050	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthAA220_11060	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthAA220_11070	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthAA220_11110	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthAA220_11140	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA220_11160	COG0159	tryptophan synthase activity
TthAA220_11170	COG0133	tryptophan synthase activity
TthAA220_11180	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthAA220_11190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA220_11310	COG0438	transferase activity, transferring glycosyl groups
TthAA220_11320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA220_11340	COG0039	L-malate dehydrogenase activity
TthAA220_11350	COG2819	hydrolase of the alpha beta superfamily
TthAA220_11360	COG0861	Integral membrane protein TerC family
TthAA220_11380	COG2181	nitrate reductase activity
TthAA220_11380	COG0247	lactate metabolic process
TthAA220_11400	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthAA220_11410	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthAA220_11420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthAA220_11440	COG0439	Biotin carboxylase
TthAA220_11450	COG0511	ligase activity, forming carbon-carbon bonds
TthAA220_11460	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthAA220_11500	COG0010	Belongs to the arginase family
TthAA220_11530	COG1100	Small GTP-binding protein
TthAA220_11550	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAA220_11560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA220_11580	COG2814	Major facilitator Superfamily
TthAA220_11590	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthAA220_11600	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA220_11610	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA220_11620	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthAA220_11630	COG0589	response to stress
TthAA220_11660	COG3335	DDE superfamily endonuclease
TthAA220_11680	COG2239	Acts as a magnesium transporter
TthAA220_11690	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthAA220_11700	COG0745	RESPONSE REGULATOR receiver
TthAA220_11710	COG5002	protein histidine kinase activity
TthAA220_11720	COG1960	acyl-CoA dehydrogenase activity
TthAA220_11730	COG2086	electron transfer activity
TthAA220_11740	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthAA220_11760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA220_11770	COG1573	uracil-dna glycosylase
TthAA220_11780	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA220_11780	COG1796	DNA polymerase
TthAA220_11810	COG2309	aminopeptidase activity
TthAA220_11830	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA220_11890	COG2873	o-acetylhomoserine
TthAA220_11920	COG1126	abc transporter atp-binding protein
TthAA220_11950	COG0134	indole-3-glycerol-phosphate synthase activity
TthAA220_11960	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthAA220_11980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthAA220_12000	COG0525	valine-tRNA ligase activity
TthAA220_12010	COG0765	amino acid transport
TthAA220_12020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthAA220_12040	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthAA220_12050	COG0569	domain protein
TthAA220_12060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA220_12070	COG1426	Protein conserved in bacteria
TthAA220_12080	COG2313	pseudouridylate synthase activity
TthAA220_12110	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA220_12130	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthAA220_12170	COG0012	GTP binding
TthAA220_12180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthAA220_12200	COG0424	maF-like protein
TthAA220_12230	COG0768	penicillin binding
TthAA220_12290	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthAA220_12300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA220_12320	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthAA220_12360	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA220_12380	COG1131	(ABC) transporter
TthAA220_12410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAA220_12440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthAA220_12450	COG0440	acetolactate synthase activity
TthAA220_12460	COG0028	Belongs to the TPP enzyme family
TthAA220_12470	COG0492	ferredoxin-NADP+ reductase activity
TthAA220_12550	COG4636	protein conserved in cyanobacteria
TthAA220_12620	COG0180	Tryptophanyl-tRNA synthetase
TthAA220_12630	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA220_12640	COG0066	3-isopropylmalate dehydratase activity
TthAA220_12650	COG0473	3-isopropylmalate dehydrogenase activity
TthAA220_12680	COG0300	oxidoreductase activity
TthAA220_12690	COG0129	dihydroxy-acid dehydratase activity
TthAA220_12710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthAA220_12720	COG1177	transmembrane transport
TthAA220_12730	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthAA220_12740	COG3842	ATPase activity
TthAA220_12750	COG0772	Belongs to the SEDS family
TthAA220_12760	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthAA220_12770	COG2894	cell division
TthAA220_12780	COG1733	regulation of RNA biosynthetic process
TthAA220_12820	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA220_12830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA220_12840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA220_12850	COG0653	protein targeting
TthAA220_12860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthAA220_12900	COG0393	Putative heavy-metal-binding
TthAA220_12910	COG1111	helicase
TthAA220_12910	COG1205	dead DEAH box helicase
TthAA220_12940	COG0358	DNA primase activity
TthAA220_12970	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA220_12980	COG0697	spore germination
TthAA220_12990	COG0612	Peptidase, M16
TthAA220_13000	COG0612	Peptidase, M16
TthAA220_13010	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthAA220_13040	COG1394	ATPase activity, coupled to movement of substances
TthAA220_13050	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthAA220_13060	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthAA220_13070	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA220_13080	COG1527	subunit (C
TthAA220_13090	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA220_13110	COG1269	ATP hydrolysis coupled proton transport
TthAA220_13180	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA220_13200	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA220_13230	COG0419	ATPase involved in DNA repair
TthAA220_13240	COG0420	3'-5' exonuclease activity
TthAA220_13280	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthAA220_13290	COG2884	Cell division ATP-binding protein ftsE
TthAA220_13300	COG0793	Belongs to the peptidase S41A family
TthAA220_13310	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA220_13310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA220_13320	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthAA220_13330	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAA220_13380	COG1129	ABC transporter
TthAA220_13390	COG0746	molybdenum cofactor guanylyltransferase activity
TthAA220_13410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA220_13450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthAA220_13460	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA220_13470	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthAA220_13490	COG1994	Peptidase M50
TthAA220_13490	COG0517	IMP dehydrogenase activity
TthAA220_13550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA220_13560	COG0788	formyltetrahydrofolate deformylase activity
TthAA220_13570	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthAA220_13580	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthAA220_13590	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthAA220_13630	COG0737	Belongs to the 5'-nucleotidase family
TthAA220_13640	COG0174	glutamine synthetase
TthAA220_13660	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA220_13690	COG0410	ABC transporter
TthAA220_13700	COG0747	negative chemotaxis
TthAA220_13740	COG0285	dihydrofolate synthase activity
TthAA220_13750	COG1132	(ABC) transporter
TthAA220_13760	COG1132	(ABC) transporter
TthAA220_13770	COG0372	Belongs to the citrate synthase family
TthAA220_13780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthAA220_13790	COG1482	cell wall glycoprotein biosynthetic process
TthAA220_13810	COG1515	deoxyribonuclease V activity
TthAA220_13830	COG0776	regulation of translation
TthAA220_13860	COG2197	response regulator
TthAA220_13870	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthAA220_13880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthAA220_13890	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthAA220_13900	COG1324	tolerance protein
TthAA220_13910	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA220_13950	COG2205	protein histidine kinase activity
TthAA220_13990	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthAA220_14080	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TthAA220_14090	COG0247	lactate metabolic process
TthAA220_14100	COG1139	Iron-sulfur cluster binding protein
TthAA220_14110	COG1556	Lactate utilization protein
TthAA220_14130	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthAA220_14140	COG0515	serine threonine protein kinase
TthAA220_14140	COG2815	serine threonine protein kinase
TthAA220_14150	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthAA220_14170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthAA220_14210	COG0473	3-isopropylmalate dehydrogenase activity
TthAA220_14260	COG1450	Type ii and iii secretion system protein
TthAA220_14270	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthAA220_14280	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthAA220_14290	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthAA220_14300	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthAA220_14300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA220_14310	COG0736	holo-[acyl-carrier-protein] synthase activity
TthAA220_14340	COG1160	GTP binding
TthAA220_14350	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthAA220_14360	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthAA220_14360	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthAA220_14370	COG2814	Major facilitator Superfamily
TthAA220_14380	COG0083	homoserine kinase activity
TthAA220_14400	COG0268	Binds directly to 16S ribosomal RNA
TthAA220_14420	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthAA220_14430	COG0723	plastoquinol--plastocyanin reductase activity
TthAA220_14450	COG3088	subunit of a heme lyase
TthAA220_14450	COG4235	cytochrome complex assembly
TthAA220_14460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA220_14470	COG1138	Cytochrome C-type biogenesis protein
TthAA220_14480	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthAA220_14490	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA220_14500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA220_14510	COG4133	protoheme IX ABC transporter activity
TthAA220_14520	COG0785	Cytochrome C biogenesis protein
TthAA220_14530	COG3258	Cytochrome c
TthAA220_14550	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA220_14580	COG3258	Cytochrome c
TthAA220_14590	COG2010	Cytochrome c
TthAA220_14600	COG0737	Belongs to the 5'-nucleotidase family
TthAA220_14610	COG2010	Cytochrome c
TthAA220_14620	COG3258	Cytochrome c
TthAA220_14660	COG2010	Cytochrome c
TthAA220_14670	COG3842	ATPase activity
TthAA220_14730	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA220_14740	COG3360	Dodecin
TthAA220_14770	COG1024	Enoyl-CoA hydratase
TthAA220_14780	COG0813	purine-nucleoside phosphorylase activity
TthAA220_14790	COG1136	(ABC) transporter
TthAA220_14800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA220_14810	COG2045	Belongs to the ComB family
TthAA220_14830	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthAA220_14850	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthAA220_14870	COG0107	imidazoleglycerol-phosphate synthase activity
TthAA220_14880	COG0140	phosphoribosyl-ATP diphosphatase activity
TthAA220_14880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthAA220_14890	COG1494	fructose-1,6-bisphosphatase
TthAA220_14900	COG0686	Belongs to the AlaDH PNT family
TthAA220_14910	COG0427	acetyl-CoA hydrolase
TthAA220_14920	COG0084	hydrolase, TatD family'
TthAA220_14930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthAA220_14950	COG0017	Asparaginyl-tRNA synthetase
TthAA220_14980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA220_15010	COG2009	succinate dehydrogenase
TthAA220_15020	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA220_15080	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA220_15090	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthAA220_15100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthAA220_15110	COG0504	CTP synthase activity
TthAA220_15150	COG0070	glutamate synthase
TthAA220_15150	COG0067	glutamate synthase
TthAA220_15150	COG0069	glutamate synthase activity
TthAA220_15260	COG0840	transmembrane signaling receptor activity
TthAA220_15270	COG0305	Participates in initiation and elongation during chromosome replication
TthAA220_15290	COG0475	glutathione-regulated potassium exporter activity
TthAA220_15300	COG0517	IMP dehydrogenase activity
TthAA220_15300	COG1227	inorganic diphosphatase activity
TthAA220_15330	COG0475	glutathione-regulated potassium exporter activity
TthAA220_15340	COG0490	domain, Protein
TthAA220_15380	COG3118	belongs to the thioredoxin family
TthAA220_15400	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAA220_15460	COG0542	response to heat
TthAA220_15470	COG0789	Transcriptional regulator
TthAA220_15480	COG0484	heat shock protein binding
TthAA220_15490	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthAA220_15500	COG0443	Heat shock 70 kDa protein
TthAA220_15510	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthAA220_15520	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthAA220_15530	COG0616	signal peptide processing
TthAA220_15540	COG1714	RDD family
TthAA220_15560	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthAA220_15570	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA220_15580	COG0714	Associated with various cellular activities
TthAA220_15590	COG0574	Belongs to the PEP-utilizing enzyme family
TthAA220_15590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAA220_15610	COG3850	Histidine kinase
TthAA220_15610	COG5002	protein histidine kinase activity
TthAA220_15660	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthAA220_15740	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthAA220_15770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthAA220_15790	COG0047	phosphoribosylformylglycinamidine synthase activity
TthAA220_15810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthAA220_15820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthAA220_15830	COG0116	Belongs to the methyltransferase superfamily
TthAA220_15860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthAA220_15870	COG0497	DNA recombination
TthAA220_15890	COG0604	alcohol dehydrogenase
TthAA220_15930	COG0585	pseudouridine synthase activity
TthAA220_15980	COG1595	DNA-templated transcription, initiation
TthAA220_15990	COG0557	exoribonuclease II activity
TthAA220_16000	COG0538	isocitrate dehydrogenase activity
TthAA220_16010	COG2022	thiamine diphosphate biosynthetic process
TthAA220_16010	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA220_16020	COG0582	viral genome integration into host DNA
TthAA220_16100	COG0590	tRNA wobble adenosine to inosine editing
TthAA220_16100	COG0037	tRNA processing
TthAA220_16140	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA220_16160	COG0322	excinuclease ABC activity
TthAA220_16170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA220_16180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA220_16190	COG1854	S-ribosylhomocysteine lyase activity
TthAA220_16220	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAA220_16220	COG0519	Catalyzes the synthesis of GMP from XMP
TthAA220_16230	COG4636	protein conserved in cyanobacteria
TthAA220_16240	COG4274	PFAM GYD family protein
TthAA220_16250	COG0346	lactoylglutathione lyase activity
TthAA220_16290	COG0328	RNA-DNA hybrid ribonuclease activity
TthAA220_16300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA220_16310	COG2095	MarC family integral membrane protein
TthAA220_16320	COG1438	arginine binding
TthAA220_16330	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthAA220_16340	COG1758	RNA polymerase activity
TthAA220_16350	COG0194	GDP metabolic process
TthAA220_16370	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthAA220_16380	COG2385	sporulation resulting in formation of a cellular spore
TthAA220_16390	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthAA220_16410	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA220_16490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA220_16500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA220_16510	COG1012	belongs to the aldehyde dehydrogenase family
TthAA220_16520	COG0506	proline dehydrogenase activity
TthAA220_16550	COG0156	8-amino-7-oxononanoate synthase activity
TthAA220_16560	COG0732	type I restriction modification DNA specificity domain
TthAA220_16560	COG0827	DNA restriction-modification system
TthAA220_16580	COG0187	DNA topoisomerase II activity
TthAA220_16590	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthAA220_16600	COG0193	aminoacyl-tRNA hydrolase activity
TthAA220_16610	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthAA220_16660	COG0515	serine threonine protein kinase
TthAA220_16660	COG2815	serine threonine protein kinase
TthAA220_16670	COG0631	protein serine/threonine phosphatase activity
TthAA220_16690	COG2814	Major facilitator Superfamily
TthAA220_16700	COG0113	porphobilinogen synthase activity
TthAA220_16710	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthAA220_16720	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthAA220_16770	COG0823	Involved in the tonB-independent uptake of proteins
TthAA220_16770	COG1506	peptidase
TthAA220_16770	COG4946	Tricorn protease homolog
TthAA220_16780	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthAA220_16790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthAA220_16830	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthAA220_16840	COG1011	Hydrolase
TthAA220_16890	COG0537	adenosine 5'-monophosphoramidase activity
TthAA220_16900	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA220_16910	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthAA220_16920	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthAA220_16930	COG0071	Belongs to the small heat shock protein (HSP20) family
TthAA220_16940	COG2897	thiosulfate sulfurtransferase activity
TthAA220_16950	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA220_16970	COG1764	response to oxidative stress
TthAA220_17020	COG3842	ATPase activity
TthAA220_17030	COG0101	tRNA pseudouridine synthase activity
TthAA220_17040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA220_17050	COG0601	transmembrane transport
TthAA220_17060	COG0747	negative chemotaxis
TthAA220_17090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA220_17120	COG1166	arginine decarboxylase activity
TthAA220_17130	COG3706	GGDEF domain
TthAA220_17140	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthAA220_17150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthAA220_17160	COG1611	Belongs to the LOG family
TthAA220_17170	COG1193	negative regulation of DNA recombination
TthAA220_17180	COG0366	Alpha amylase catalytic
TthAA220_17210	COG3833	ABC-type maltose transport systems, permease component
TthAA220_17220	COG1175	transmembrane transport
TthAA220_17250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthAA220_17260	COG0142	geranyltranstransferase activity
TthAA220_17350	COG0203	ribosomal protein L17
TthAA220_17360	COG0202	RNA polymerase activity
TthAA220_17370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthAA220_17380	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthAA220_17390	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthAA220_17400	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthAA220_17420	COG0563	adenylate kinase activity
TthAA220_17430	COG0201	protein transport
TthAA220_17440	COG0200	Binds to the 23S rRNA
TthAA220_17450	COG1841	ribosomal large subunit assembly
TthAA220_17460	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TthAA220_17470	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TthAA220_17480	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthAA220_17490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthAA220_17500	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthAA220_17510	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TthAA220_17520	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TthAA220_17540	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TthAA220_17550	COG0255	Belongs to the universal ribosomal protein uL29 family
TthAA220_17560	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthAA220_17570	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthAA220_17580	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TthAA220_17590	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthAA220_17600	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthAA220_17610	COG0089	rRNA binding
TthAA220_17620	COG0088	Forms part of the polypeptide exit tunnel
TthAA220_17630	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TthAA220_17640	COG0051	transcription antitermination factor activity, RNA binding
TthAA220_17650	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA220_17660	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA220_17670	COG0049	tRNA binding
TthAA220_17680	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TthAA220_17700	COG0442	prolyl-tRNA aminoacylation
TthAA220_17720	COG1115	amino acid carrier protein
TthAA220_17760	COG1489	DNA binding
TthAA220_17830	COG0432	Pfam Uncharacterised protein family UPF0047
TthAA220_17850	COG0668	transmembrane transport
TthAA220_17870	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthAA220_17880	COG2217	Heavy metal translocating P-type atpase
TthAA220_17930	COG3335	DDE superfamily endonuclease
TthAA220_17940	COG0745	RESPONSE REGULATOR receiver
TthAA220_17950	COG2205	protein histidine kinase activity
TthAA220_18000	COG2226	methyltransferase
TthAA220_18040	COG2132	Multicopper oxidase
TthAA220_18060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthAA220_18070	COG0822	iron-sulfur transferase activity
TthAA220_18110	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthAA220_18130	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthAA220_18140	COG0284	orotidine-5'-phosphate decarboxylase activity
TthAA220_18160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA220_18180	COG0416	fatty acid biosynthetic process
TthAA220_18190	COG3118	belongs to the thioredoxin family
TthAA220_18200	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA220_18230	COG0438	transferase activity, transferring glycosyl groups
TthAA220_18260	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthAA220_18270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA220_18280	COG3706	GGDEF domain
TthAA220_18350	COG0437	4 iron, 4 sulfur cluster binding
TthAA220_18380	COG0825	malonyl-CoA metabolic process
TthAA220_18390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthAA220_18460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthAA220_18510	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthAA220_18520	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthAA220_18530	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthAA220_18540	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthAA220_18560	COG4974	Belongs to the 'phage' integrase family
TthAA220_18730	COG0315	cyclic pyranopterin monophosphate synthase activity
TthAA220_18740	COG2860	membrane
TthAA220_18760	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthAA220_18790	COG0477	Major facilitator Superfamily
TthAA220_18800	COG1694	Mazg nucleotide pyrophosphohydrolase
TthAA220_18810	COG1803	Methylglyoxal synthase
TthAA220_18830	COG0301	tRNA thio-modification
TthAA220_18840	COG0154	amidase activity
TthAA220_18850	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthAA220_18880	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthAA220_18890	COG1607	acyl-coa hydrolase
TthAA220_18910	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthAA220_18920	COG4149	molybdate abc transporter
TthAA220_18930	COG1840	ABC-type Fe3 transport system, periplasmic component
TthAA220_18960	COG0235	Class ii aldolase
TthAA220_18970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthAA220_18980	COG0085	RNA polymerase activity
TthAA220_19000	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthAA220_19010	COG1077	Cell shape determining protein MreB Mrl
TthAA220_19020	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthAA220_19020	COG1418	mRNA catabolic process
TthAA220_19030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthAA220_19040	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthAA220_19050	COG1546	Belongs to the CinA family
TthAA220_19050	COG1058	Belongs to the CinA family
TthAA220_19060	COG0354	folic acid binding
TthAA220_19090	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA220_19120	COG1175	transmembrane transport
TthAA220_19140	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthAA220_19160	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA220_19180	COG1136	(ABC) transporter
TthAA220_19180	COG0577	efflux transmembrane transporter activity
TthAA220_19190	COG4181	ATPase activity
TthAA220_19200	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA220_19230	COG0396	ATPase activity
TthAA220_19240	COG0719	Fe-S assembly protein
TthAA220_19250	COG0719	Fe-S assembly protein
TthAA220_19260	COG2146	nitrite reductase [NAD(P)H] activity
TthAA220_19270	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TthAA220_19280	COG0512	Glutamine amidotransferase of anthranilate synthase
TthAA220_19290	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA220_19360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA220_19370	COG2226	methyltransferase
TthAA220_19420	COG1774	PSP1 C-terminal conserved region
TthAA220_19430	COG0470	DNA polymerase III
TthAA220_19500	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthAA220_19510	COG0302	gtp cyclohydrolase
TthAA220_19560	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthAA220_19580	COG0395	ABC-type sugar transport system, permease component
TthAA220_19590	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthAA220_19600	COG1131	(ABC) transporter
TthAA220_19660	COG0556	nucleotide-excision repair
TthAA220_19670	COG0497	DNA recombination
TthAA220_19680	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthAA220_19690	COG0445	tRNA wobble uridine modification
TthAA220_19730	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA220_19730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthAA220_19740	COG1543	Belongs to the glycosyl hydrolase 57 family
TthAA220_19750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA220_19760	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA220_19770	COG0189	ligase activity
TthAA220_19800	COG0066	3-isopropylmalate dehydratase activity
TthAA220_19810	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA220_19850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthAA220_19860	COG1960	acyl-CoA dehydrogenase activity
TthAA220_19870	COG0163	prenyltransferase activity
TthAA220_19940	COG2096	Adenosyltransferase
TthAA220_19970	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthAA220_19980	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthAA220_20000	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthAA220_20010	COG0723	plastoquinol--plastocyanin reductase activity
TthAA220_20030	COG2010	Cytochrome c
TthAA220_20060	COG1653	transport
TthAA220_20070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthAA220_20080	COG1960	acyl-CoA dehydrogenase activity
TthAA220_20100	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthAA220_20160	COG1131	(ABC) transporter
TthAA220_20210	COG3956	TIGRFAM MazG family protein
TthAA220_20230	COG0693	protein deglycase activity
TthAA220_20240	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA220_20260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthAA220_20270	COG1937	Protein conserved in bacteria
TthAA220_20290	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthAA220_20290	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthAA220_20300	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthAA220_20310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA220_20320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TthAA220_20330	COG0072	phenylalanine-tRNA ligase activity
TthAA220_20330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA220_20350	COG0205	6-phosphofructokinase activity
TthAA220_20360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthAA220_20380	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthAA220_20410	COG0658	competence protein
TthAA220_20410	COG2333	competence protein COMEC
TthAA220_20420	COG1475	DNA binding
TthAA220_20430	COG1192	Involved in chromosome partitioning
TthAA220_20440	COG0357	Ribosomal RNA small subunit methyltransferase G
TthAA220_20450	COG0445	tRNA wobble uridine modification
TthAA220_20470	COG3335	DDE superfamily endonuclease
TthAA220_20480	COG2211	Major facilitator Superfamily
TthAA220_20530	COG2211	Major facilitator Superfamily
TthAA220_20550	COG0739	heme binding
TthAA220_20700	COG1175	transmembrane transport
TthAA220_20720	COG1609	Transcriptional regulator
TthAA220_20750	COG0863	Belongs to the N(4) N(6)-methyltransferase family
TthAA220_20800	COG1857	crispr-associated protein
TthAA220_20840	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TthAA220_20850	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthAA220_20900	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthAA220_20910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAA220_20940	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TthAA220_20950	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthAA220_21020	COG2010	Cytochrome c
TthAA220_21100	COG2205	protein histidine kinase activity
TthAA220_21110	COG0745	RESPONSE REGULATOR receiver
TthAA220_21120	COG2010	Cytochrome c
TthAA220_21210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TthAA220_21220	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TthAA220_21230	COG0363	glucosamine-6-phosphate deaminase activity
TthAA220_21260	COG0730	response to heat
TthAA220_21320	COG0671	phosphoesterase, PA-phosphatase related
TthAA220_21330	COG0745	RESPONSE REGULATOR receiver
TthAA220_21340	COG0745	RESPONSE REGULATOR receiver
TthAA220_21350	COG0642	Histidine kinase
TthAA220_21360	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA220_21380	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA220_21420	COG2329	Antibiotic biosynthesis monooxygenase
TthAA220_21580	COG0745	RESPONSE REGULATOR receiver
TthAA220_21590	COG3850	Histidine kinase
TthAA220_21590	COG5002	protein histidine kinase activity
TthAA220_21720	COG1942	4-Oxalocrotonate Tautomerase
TthAA220_21740	COG2084	Dehydrogenase
TthAA220_21820	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TthAA220_21830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAA220_21870	COG2010	Cytochrome c
TthAA220_21890	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA220_21910	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TthAA220_21960	COG1252	NADH dehydrogenase
TthAA220_21970	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA220_21990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA220_22120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthAA220_22160	COG2010	Cytochrome c
TthAA220_22170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthAA220_22200	COG3256	nitric oxide reductase
TthAA220_22280	COG0243	molybdopterin cofactor binding
TthAA220_22300	COG1192	Involved in chromosome partitioning
TthAA220_22310	COG1475	DNA binding
TthAA220_22330	COG1475	DNA binding
TthAA220_22400	COG3345	alpha-galactosidase
TthAA220_22410	COG1085	galactose-1-phosphate uridylyltransferase
TthAA220_22470	COG1304	FMN binding
TthAA220_22490	COG1487	ribonuclease activity
TthAA220_22540	COG2124	cytochrome p450
TthAA220_22560	COG1562	ergosterol biosynthetic process
TthAA220_22580	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA220_22600	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA220_22610	COG2723	6-phospho-beta-galactosidase activity
TthAA220_22630	COG1175	transmembrane transport
TthAA220_22660	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA220_22670	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA220_22690	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthAA220_22700	COG0800	Aldolase
TthAA220_22760	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TthAA220_22770	COG1785	Belongs to the alkaline phosphatase family
TthAA220_22780	COG1492	cobalamin metabolic process
TthAA220_22850	COG0778	Nitroreductase
TthAA220_22860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA220_22860	COG1648	precorrin-2 dehydrogenase activity
TthAA220_22950	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthAA220_22960	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthAA220_22970	COG0588	phosphoglycerate mutase activity
TthAA220_23000	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthAA220_23020	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TthAA220_23030	COG1797	cobyrinic acid a,c-diamide synthase activity
TthAA220_t00340	COG0544	peptidyl-prolyl cis-trans isomerase activity