locus-tag	class	description
TthAA37_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthAA37_00020	COG0592	DNA-directed DNA polymerase activity
TthAA37_00030	COG0148	phosphopyruvate hydratase activity
TthAA37_00040	COG0469	pyruvate kinase activity
TthAA37_00070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA37_00080	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthAA37_00100	COG1842	Phage shock protein A
TthAA37_00140	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthAA37_00150	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA37_00170	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthAA37_00180	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthAA37_00190	COG1496	oxidoreductase activity
TthAA37_00200	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA37_00210	COG1278	Cold shock
TthAA37_00240	COG1653	transport
TthAA37_00270	COG0033	Phosphoglucomutase
TthAA37_00290	COG2814	Major facilitator Superfamily
TthAA37_00310	COG0517	IMP dehydrogenase activity
TthAA37_00310	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthAA37_00320	COG1950	PFAM Membrane protein of
TthAA37_00330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthAA37_00350	COG0181	hydroxymethylbilane synthase activity
TthAA37_00370	COG0285	dihydrofolate synthase activity
TthAA37_00380	COG0436	Aminotransferase
TthAA37_00390	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthAA37_00440	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthAA37_00450	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthAA37_00460	COG1993	acr, cog1993
TthAA37_00470	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthAA37_00490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA37_00510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthAA37_00520	COG1335	isochorismatase
TthAA37_00530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthAA37_00560	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthAA37_00570	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthAA37_00610	COG1660	Displays ATPase and GTPase activities
TthAA37_00620	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthAA37_00710	COG3335	DDE superfamily endonuclease
TthAA37_00730	COG1845	cytochrome c oxidase, subunit III
TthAA37_00730	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA37_00740	COG2010	Cytochrome c
TthAA37_00740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAA37_00750	COG1612	heme a metabolic process
TthAA37_00750	COG0109	protoheme IX farnesyltransferase activity
TthAA37_00780	COG0343	queuine tRNA-ribosyltransferase activity
TthAA37_00790	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthAA37_00800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthAA37_00940	COG1940	carbohydrate kinase activity
TthAA37_00960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA37_00970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA37_00980	COG0589	response to stress
TthAA37_00990	COG1611	Belongs to the LOG family
TthAA37_01010	COG1011	Hydrolase
TthAA37_01020	COG0632	four-way junction helicase activity
TthAA37_01030	COG1024	Enoyl-CoA hydratase
TthAA37_01050	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA37_01120	COG0137	argininosuccinate synthase activity
TthAA37_01130	COG0165	Argininosuccinate lyase
TthAA37_01150	COG0505	Belongs to the CarA family
TthAA37_01170	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthAA37_01180	COG0166	Belongs to the GPI family
TthAA37_01200	COG0714	Associated with various cellular activities
TthAA37_01230	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA37_01240	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthAA37_01250	COG0459	protein refolding
TthAA37_01260	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthAA37_01270	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthAA37_01290	COG0778	Nitroreductase
TthAA37_01300	COG1388	LysM domain
TthAA37_01300	COG0791	NLP P60 protein
TthAA37_01320	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthAA37_01340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthAA37_01350	COG0581	inorganic phosphate transmembrane transporter activity
TthAA37_01360	COG0573	inorganic phosphate transmembrane transporter activity
TthAA37_01380	COG0482	sulfurtransferase activity
TthAA37_01400	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthAA37_01410	COG0735	belongs to the Fur family
TthAA37_01440	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthAA37_01450	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA37_01460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthAA37_01470	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthAA37_01480	COG0250	Participates in transcription elongation, termination and antitermination
TthAA37_01500	COG0081	regulation of translation
TthAA37_01520	COG0629	single-stranded DNA binding
TthAA37_01530	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthAA37_01540	COG0359	binds to the 23S rRNA
TthAA37_01580	COG0300	oxidoreductase activity
TthAA37_01590	COG0321	lipoyl(octanoyl) transferase activity
TthAA37_01600	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthAA37_01650	COG1476	TRANSCRIPTIONal
TthAA37_01690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthAA37_01720	COG1598	PFAM Uncharacterised protein family UPF0150
TthAA37_01730	COG0022	dehydrogenase e1 component
TthAA37_01740	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthAA37_01750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthAA37_01800	COG2226	methyltransferase
TthAA37_01810	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthAA37_01830	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthAA37_01840	COG1187	pseudouridine synthase activity
TthAA37_01860	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthAA37_01870	COG0686	Belongs to the AlaDH PNT family
TthAA37_01890	COG1461	Dihydroxyacetone kinase
TthAA37_01930	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthAA37_01940	COG0222	ribosome binding
TthAA37_01950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthAA37_01970	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthAA37_02000	COG0697	spore germination
TthAA37_02020	COG3177	Filamentation induced by cAMP protein fic
TthAA37_02040	COG0243	molybdopterin cofactor binding
TthAA37_02050	COG2272	Belongs to the type-B carboxylesterase lipase family
TthAA37_02060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthAA37_02080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA37_02110	COG0477	Major facilitator Superfamily
TthAA37_02140	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthAA37_02160	COG0105	UTP biosynthetic process
TthAA37_02170	COG0631	protein serine/threonine phosphatase activity
TthAA37_02180	COG0583	DNA-binding transcription factor activity
TthAA37_02200	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAA37_02260	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA37_02290	COG3335	DDE superfamily endonuclease
TthAA37_02330	COG3335	DDE superfamily endonuclease
TthAA37_02340	COG1278	Cold shock
TthAA37_02350	COG0484	heat shock protein binding
TthAA37_02360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthAA37_02370	COG1968	undecaprenyl-diphosphatase activity
TthAA37_02380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthAA37_02390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthAA37_02420	COG1309	transcriptional regulator
TthAA37_02430	COG4242	Belongs to the peptidase S51 family
TthAA37_02460	COG0802	atpase or kinase
TthAA37_02470	COG0539	negative regulation of cytoplasmic translation
TthAA37_02480	COG0495	leucyl-tRNA aminoacylation
TthAA37_02510	COG3335	DDE superfamily endonuclease
TthAA37_02570	COG1902	pentaerythritol trinitrate reductase activity
TthAA37_02600	COG3335	DDE superfamily endonuclease
TthAA37_02670	COG2414	aldehyde ferredoxin oxidoreductase
TthAA37_02690	COG2165	general secretion pathway protein
TthAA37_02710	COG2165	general secretion pathway protein
TthAA37_02770	COG1459	type II secretion system
TthAA37_02790	COG1187	pseudouridine synthase activity
TthAA37_02810	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA37_02820	COG0745	RESPONSE REGULATOR receiver
TthAA37_02830	COG4191	Histidine kinase
TthAA37_02840	COG0704	Plays a role in the regulation of phosphate uptake
TthAA37_02850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthAA37_02870	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthAA37_02890	COG0515	serine threonine protein kinase
TthAA37_02890	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthAA37_02930	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthAA37_02940	COG0300	oxidoreductase activity
TthAA37_02970	COG0717	Belongs to the dCTP deaminase family
TthAA37_02980	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthAA37_02990	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthAA37_03000	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAA37_03060	COG3546	catalase activity
TthAA37_03070	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA37_03070	COG0758	DNA mediated transformation
TthAA37_03080	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthAA37_03100	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA37_03120	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthAA37_03140	COG0442	prolyl-tRNA aminoacylation
TthAA37_03200	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthAA37_03240	COG0303	'Molybdopterin
TthAA37_03250	COG0513	Belongs to the DEAD box helicase family
TthAA37_03270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthAA37_03290	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthAA37_03350	COG2070	2-Nitropropane dioxygenase
TthAA37_03380	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthAA37_03390	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA37_03400	COG0018	arginyl-trna synthetase
TthAA37_03410	COG1007	ATP synthesis coupled electron transport
TthAA37_03420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA37_03430	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthAA37_03440	COG0713	ATP synthesis coupled electron transport
TthAA37_03450	COG0839	Belongs to the complex I subunit 6 family
TthAA37_03460	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA37_03470	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthAA37_03480	COG1034	ATP synthesis coupled electron transport
TthAA37_03490	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthAA37_03500	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthAA37_03510	COG0649	NAD binding
TthAA37_03520	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA37_03530	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA37_03540	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAA37_03550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthAA37_03570	COG4712	double-strand break repair protein
TthAA37_03650	COG0135	phosphoribosylanthranilate isomerase activity
TthAA37_03670	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthAA37_03690	COG2720	vancomycin resistance protein
TthAA37_03710	COG3335	DDE superfamily endonuclease
TthAA37_03720	COG1126	abc transporter atp-binding protein
TthAA37_03790	COG0277	FAD linked oxidase domain protein
TthAA37_03820	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthAA37_03830	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthAA37_03860	COG0314	molybdopterin synthase activity
TthAA37_03870	COG1420	regulation of RNA biosynthetic process
TthAA37_03880	COG0347	Belongs to the P(II) protein family
TthAA37_03890	COG0004	ammonium transporteR
TthAA37_03910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthAA37_03930	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA37_03970	COG1597	lipid kinase activity
TthAA37_03980	COG0436	Aminotransferase
TthAA37_04000	COG0475	glutathione-regulated potassium exporter activity
TthAA37_04000	COG0569	domain protein
TthAA37_04020	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthAA37_04040	COG0277	FAD linked oxidase domain protein
TthAA37_04090	COG0667	Aldo Keto reductase
TthAA37_04150	COG1067	ATP-dependent peptidase activity
TthAA37_04160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthAA37_04180	COG0745	RESPONSE REGULATOR receiver
TthAA37_04190	COG2105	PFAM AIG2 family protein
TthAA37_04200	COG0297	glycogen (starch) synthase activity
TthAA37_04220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthAA37_04230	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthAA37_04260	COG0142	geranyltranstransferase activity
TthAA37_04280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthAA37_04290	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_04300	COG0492	ferredoxin-NADP+ reductase activity
TthAA37_04320	COG0792	nuclease activity
TthAA37_04330	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthAA37_04360	COG1175	transmembrane transport
TthAA37_04370	COG0395	ABC-type sugar transport system, permease component
TthAA37_04430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthAA37_04440	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthAA37_04450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthAA37_04460	COG0805	protein transport
TthAA37_04470	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA37_04470	COG1605	Chorismate mutase
TthAA37_04600	COG1063	alcohol dehydrogenase
TthAA37_04660	COG2255	four-way junction helicase activity
TthAA37_04670	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthAA37_04680	COG0564	pseudouridine synthase activity
TthAA37_04710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthAA37_04730	COG3335	DDE superfamily endonuclease
TthAA37_04740	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthAA37_04750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthAA37_04760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthAA37_04780	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthAA37_04790	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthAA37_04800	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthAA37_04870	COG0778	Nitroreductase
TthAA37_04900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthAA37_04910	COG0131	Imidazoleglycerol-phosphate dehydratase
TthAA37_04920	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthAA37_04930	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAA37_04940	COG0517	IMP dehydrogenase activity
TthAA37_04940	COG0516	GMP reductase activity
TthAA37_04970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthAA37_04980	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA37_05010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA37_05050	COG0706	membrane insertase activity
TthAA37_05060	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthAA37_05070	COG0594	ribonuclease P activity
TthAA37_05090	COG1022	Amp-dependent synthetase and ligase
TthAA37_05140	COG1121	(ABC) transporter
TthAA37_05150	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthAA37_05160	COG1959	2 iron, 2 sulfur cluster binding
TthAA37_05170	COG1104	cysteine desulfurase activity
TthAA37_05180	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthAA37_05190	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthAA37_05220	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_05260	COG0492	ferredoxin-NADP+ reductase activity
TthAA37_05270	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_05270	COG3321	synthase
TthAA37_05270	COG0604	alcohol dehydrogenase
TthAA37_05300	COG0747	negative chemotaxis
TthAA37_05310	COG0601	transmembrane transport
TthAA37_05320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA37_05350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA37_05350	COG0617	tRNA 3'-terminal CCA addition
TthAA37_05350	COG0517	IMP dehydrogenase activity
TthAA37_05360	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAA37_05370	COG2104	thiamine diphosphate biosynthetic process
TthAA37_05380	COG0037	tRNA processing
TthAA37_05410	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthAA37_05430	COG4176	ABC-type proline glycine betaine transport system permease component
TthAA37_05440	COG3448	diguanylate cyclase activity
TthAA37_05440	COG4175	Glycine betaine
TthAA37_05460	COG0366	Alpha amylase catalytic
TthAA37_05470	COG2226	methyltransferase
TthAA37_05480	COG2226	methyltransferase
TthAA37_05490	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthAA37_05510	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthAA37_05520	COG0460	homoserine dehydrogenase
TthAA37_05540	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthAA37_05610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthAA37_05650	COG0247	lactate metabolic process
TthAA37_05660	COG0277	FAD linked oxidase domain protein
TthAA37_05670	COG0277	FAD linked oxidase domain protein
TthAA37_05680	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthAA37_05690	COG1414	Transcriptional regulator
TthAA37_05700	COG0789	Transcriptional regulator
TthAA37_05720	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA37_05730	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA37_05800	COG0861	Integral membrane protein TerC family
TthAA37_05810	COG2151	metal-sulfur cluster biosynthetic enzyme
TthAA37_05820	COG0281	malic enzyme
TthAA37_05850	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthAA37_05860	COG0509	glycine decarboxylation via glycine cleavage system
TthAA37_05870	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA37_05880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAA37_05890	COG0196	riboflavin kinase activity
TthAA37_05940	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthAA37_05950	COG2813	Specifically methylates the guanine in position
TthAA37_05960	COG0527	aspartate kinase activity
TthAA37_06020	COG4956	integral membrane protein (PIN domain superfamily)
TthAA37_06030	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthAA37_06040	COG0542	response to heat
TthAA37_06050	COG0423	glycine-tRNA ligase activity
TthAA37_06070	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthAA37_06110	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA37_06110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAA37_06130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthAA37_06150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthAA37_06170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA37_06180	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA37_06190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthAA37_06200	COG0114	fumarate hydratase activity
TthAA37_06210	COG0183	Belongs to the thiolase family
TthAA37_06240	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthAA37_06250	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthAA37_06280	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthAA37_06290	COG1254	Belongs to the acylphosphatase family
TthAA37_06320	COG1063	alcohol dehydrogenase
TthAA37_06330	COG2133	pyrroloquinoline quinone binding
TthAA37_06350	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthAA37_06360	COG0154	amidase activity
TthAA37_06410	COG0572	uridine kinase
TthAA37_06420	COG3842	ATPase activity
TthAA37_06450	COG4475	Protein of unknown function (DUF436)
TthAA37_06500	COG1595	DNA-templated transcription, initiation
TthAA37_06640	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAA37_06650	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthAA37_06660	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthAA37_06690	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthAA37_06700	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthAA37_06710	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthAA37_06740	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_06750	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA37_06760	COG1012	belongs to the aldehyde dehydrogenase family
TthAA37_06760	COG2030	dehydratase
TthAA37_06770	COG1960	acyl-CoA dehydrogenase activity
TthAA37_06800	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthAA37_06810	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthAA37_06820	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthAA37_06840	COG3870	Protein conserved in bacteria
TthAA37_06850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthAA37_06870	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthAA37_06880	COG0740	serine-type endopeptidase activity
TthAA37_06890	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthAA37_06900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthAA37_06910	COG0646	methionine synthase
TthAA37_06910	COG1410	methionine synthase
TthAA37_06920	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA37_06970	COG1692	metallophosphoesterase
TthAA37_06980	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthAA37_07010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthAA37_07020	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthAA37_07200	COG0438	transferase activity, transferring glycosyl groups
TthAA37_07250	COG0529	Catalyzes the synthesis of activated sulfate
TthAA37_07270	COG2046	Belongs to the sulfate adenylyltransferase family
TthAA37_07300	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA37_07340	COG0489	protein tyrosine kinase activity
TthAA37_07360	COG2264	protein methyltransferase activity
TthAA37_07370	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthAA37_07440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthAA37_07450	COG2046	Belongs to the sulfate adenylyltransferase family
TthAA37_07460	COG1648	precorrin-2 dehydrogenase activity
TthAA37_07460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA37_07470	COG0730	response to heat
TthAA37_07480	COG0175	sulfate reduction
TthAA37_07490	COG1648	precorrin-2 dehydrogenase activity
TthAA37_07490	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA37_07500	COG1587	Uroporphyrinogen-III synthase
TthAA37_07510	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthAA37_07590	COG0352	thiamine-phosphate diphosphorylase activity
TthAA37_07600	COG2104	thiamine diphosphate biosynthetic process
TthAA37_07610	COG2022	thiamine diphosphate biosynthetic process
TthAA37_07620	COG2022	thiamine diphosphate biosynthetic process
TthAA37_07620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA37_07630	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthAA37_07640	COG0477	Major facilitator Superfamily
TthAA37_07650	COG0351	phosphomethylpyrimidine kinase
TthAA37_07710	COG1175	transmembrane transport
TthAA37_07730	COG1940	carbohydrate kinase activity
TthAA37_07740	COG0183	Belongs to the thiolase family
TthAA37_07770	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_07810	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA37_07830	COG2030	dehydratase
TthAA37_07850	COG0596	Alpha beta hydrolase
TthAA37_07860	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA37_07890	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA37_07890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAA37_07910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthAA37_07930	COG0195	Participates in both transcription termination and antitermination
TthAA37_07940	COG0779	Required for maturation of 30S ribosomal subunits
TthAA37_07950	COG0739	heme binding
TthAA37_07960	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthAA37_07970	COG0640	Transcriptional regulator
TthAA37_07980	COG2217	Heavy metal translocating P-type atpase
TthAA37_07990	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthAA37_08000	COG0017	Asparaginyl-tRNA synthetase
TthAA37_08010	COG0561	phosphatase activity
TthAA37_08020	COG0384	phenazine biosynthesis protein PhzF
TthAA37_08040	COG0124	histidyl-tRNA synthetase
TthAA37_08060	COG3842	ATPase activity
TthAA37_08110	COG1573	uracil-dna glycosylase
TthAA37_08160	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthAA37_08200	COG1316	TRANSCRIPTIONal
TthAA37_08210	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthAA37_08300	COG0295	cytidine deaminase activity
TthAA37_08320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthAA37_08340	COG1760	l-serine dehydratase
TthAA37_08360	COG0481	GTPase activity
TthAA37_08380	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthAA37_08390	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthAA37_08410	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_08460	COG0405	Gamma-glutamyltransferase
TthAA37_08480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthAA37_08490	COG2873	o-acetylhomoserine
TthAA37_08520	COG1063	alcohol dehydrogenase
TthAA37_08560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA37_08570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA37_08580	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAA37_08600	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthAA37_08620	COG0167	dihydroorotate dehydrogenase activity
TthAA37_08700	COG0730	response to heat
TthAA37_08710	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthAA37_08750	COG1960	acyl-CoA dehydrogenase activity
TthAA37_08760	COG0456	acetyltransferase
TthAA37_08780	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthAA37_08790	COG0009	L-threonylcarbamoyladenylate synthase
TthAA37_08800	COG1459	type II secretion system
TthAA37_08830	COG0277	FAD linked oxidase domain protein
TthAA37_08850	COG0287	Prephenate dehydrogenase
TthAA37_08860	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAA37_08870	COG2514	catechol 2,3-dioxygenase activity
TthAA37_08880	COG2353	YceI-like domain
TthAA37_08890	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA37_08900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA37_08940	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA37_08950	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthAA37_08970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthAA37_08980	COG0151	Belongs to the GarS family
TthAA37_08990	COG5002	protein histidine kinase activity
TthAA37_08990	COG2176	DNA-directed DNA polymerase activity
TthAA37_09050	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthAA37_09070	COG0217	transcriptional regulatory protein
TthAA37_09080	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthAA37_09080	COG4651	solute:proton antiporter activity
TthAA37_09090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthAA37_09100	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthAA37_09110	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA37_09120	COG1674	ftsk spoiiie
TthAA37_09150	COG0517	IMP dehydrogenase activity
TthAA37_09170	COG0617	tRNA 3'-terminal CCA addition
TthAA37_09170	COG3620	sequence-specific DNA binding
TthAA37_09170	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA37_09190	COG1994	Peptidase M50
TthAA37_09200	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthAA37_09220	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA37_09250	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAA37_09260	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA37_09270	COG2719	SpoVR family
TthAA37_09280	COG2718	Belongs to the UPF0229 family
TthAA37_09290	COG2766	serine protein kinase
TthAA37_09340	COG2137	regulation of response to DNA damage stimulus
TthAA37_09360	COG2359	stage V sporulation protein S
TthAA37_09370	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA37_09380	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthAA37_09400	COG0463	Glycosyl transferase, family 2
TthAA37_09410	COG0750	zinc metalloprotease
TthAA37_09420	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthAA37_09430	COG0575	Belongs to the CDS family
TthAA37_09440	COG0233	cytoplasmic translational termination
TthAA37_09450	COG0528	UMP kinase activity
TthAA37_09460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthAA37_09470	COG0052	Belongs to the universal ribosomal protein uS2 family
TthAA37_09480	COG0582	viral genome integration into host DNA
TthAA37_09570	COG1598	PFAM Uncharacterised protein family UPF0150
TthAA37_09650	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthAA37_09660	COG0494	nUDIX hydrolase
TthAA37_09720	COG0402	S-adenosylhomocysteine deaminase activity
TthAA37_09740	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA37_09750	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthAA37_09760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAA37_09770	COG1811	Na channel or pump
TthAA37_09780	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthAA37_09780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA37_09810	COG1215	transferase activity, transferring glycosyl groups
TthAA37_09830	COG1215	transferase activity, transferring glycosyl groups
TthAA37_09850	COG0438	transferase activity, transferring glycosyl groups
TthAA37_09860	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthAA37_09900	COG1024	Enoyl-CoA hydratase
TthAA37_09900	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA37_09910	COG0183	Belongs to the thiolase family
TthAA37_09920	COG1960	acyl-CoA dehydrogenase activity
TthAA37_09930	COG0215	cysteine-tRNA ligase activity
TthAA37_09940	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthAA37_10000	COG1196	nuclear chromosome segregation
TthAA37_10030	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthAA37_10040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA37_10040	COG3153	acetyltransferase
TthAA37_10050	COG1268	BioY protein
TthAA37_10070	COG0126	phosphoglycerate kinase activity
TthAA37_10080	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthAA37_10090	COG0824	Thioesterase
TthAA37_10110	COG0557	exoribonuclease II activity
TthAA37_10120	COG1355	regulation of microtubule-based process
TthAA37_10130	COG1353	crispr-associated protein
TthAA37_10130	COG0617	tRNA 3'-terminal CCA addition
TthAA37_10140	COG0237	dephospho-CoA kinase activity
TthAA37_10160	COG0742	ribosomal rna small subunit methyltransferase
TthAA37_10170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthAA37_10180	COG0138	bifunctional purine biosynthesis protein purh
TthAA37_10190	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthAA37_10210	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthAA37_10380	COG0149	triose-phosphate isomerase activity
TthAA37_10390	COG3239	Fatty acid desaturase
TthAA37_10430	COG1490	D-aminoacyl-tRNA deacylase activity
TthAA37_10440	COG1307	EDD domain protein, DegV family
TthAA37_10450	COG1307	EDD domain protein, DegV family
TthAA37_10460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthAA37_10470	COG1510	regulation of RNA biosynthetic process
TthAA37_10510	COG1136	(ABC) transporter
TthAA37_10540	COG3769	mannosylglycerate metabolic process
TthAA37_10560	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthAA37_10580	COG1012	belongs to the aldehyde dehydrogenase family
TthAA37_10590	COG2368	4-hydroxyphenylacetate
TthAA37_10600	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthAA37_10660	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA37_10670	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAA37_10690	COG1012	belongs to the aldehyde dehydrogenase family
TthAA37_10690	COG2030	dehydratase
TthAA37_10730	COG3396	Phenylacetate-CoA oxygenase
TthAA37_10750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthAA37_10770	COG0395	ABC-type sugar transport system, permease component
TthAA37_10810	COG1980	fructose-bisphosphate aldolase activity
TthAA37_10820	COG1733	regulation of RNA biosynthetic process
TthAA37_10830	COG2193	ferroxidase activity
TthAA37_10840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthAA37_10850	COG1331	Highly conserved protein containing a thioredoxin domain
TthAA37_10860	COG0183	Belongs to the thiolase family
TthAA37_10870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthAA37_10880	COG0477	Major facilitator Superfamily
TthAA37_10900	COG1846	Transcriptional regulator
TthAA37_10930	COG0784	Response regulator, receiver
TthAA37_10930	COG3437	response regulator, receiver
TthAA37_10940	COG3335	DDE superfamily endonuclease
TthAA37_10990	COG1012	belongs to the aldehyde dehydrogenase family
TthAA37_11000	COG0248	Ppx GppA phosphatase
TthAA37_11030	COG0210	DNA helicase
TthAA37_11080	COG1309	transcriptional regulator
TthAA37_11090	COG1131	(ABC) transporter
TthAA37_11100	COG0842	Transport permease protein
TthAA37_11180	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA37_11230	COG0582	viral genome integration into host DNA
TthAA37_11260	COG2897	thiosulfate sulfurtransferase activity
TthAA37_11270	COG1760	l-serine dehydratase
TthAA37_11280	COG2197	response regulator
TthAA37_11290	COG0335	large ribosomal subunit rRNA binding
TthAA37_11300	COG0336	Belongs to the RNA methyltransferase TrmD family
TthAA37_11310	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthAA37_11320	COG1837	Belongs to the UPF0109 family
TthAA37_11330	COG0228	four-way junction DNA binding
TthAA37_11360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA37_11370	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA37_11370	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA37_11380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthAA37_11400	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthAA37_11420	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthAA37_11430	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthAA37_11440	COG1702	phosphate starvation-inducible protein PhoH
TthAA37_11460	COG4864	UPF0365 protein
TthAA37_11480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthAA37_11500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA37_11500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAA37_11510	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAA37_11530	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthAA37_11570	COG2239	Acts as a magnesium transporter
TthAA37_11580	COG2304	oxidoreductase activity
TthAA37_11590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA37_11590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAA37_11610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA37_11610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAA37_11620	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthAA37_11630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthAA37_11640	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthAA37_11650	COG0006	proline dipeptidase activity
TthAA37_11670	COG0739	heme binding
TthAA37_11690	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthAA37_11700	COG0254	rRNA binding
TthAA37_11720	COG2001	Belongs to the MraZ family
TthAA37_11730	COG0275	rRNA processing
TthAA37_11760	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthAA37_11780	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA37_11790	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthAA37_11800	COG0772	Belongs to the SEDS family
TthAA37_11810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthAA37_11820	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthAA37_11830	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthAA37_11870	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthAA37_11900	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAA37_11940	COG3335	DDE superfamily endonuclease
TthAA37_11980	COG0159	tryptophan synthase activity
TthAA37_11990	COG0133	tryptophan synthase activity
TthAA37_12000	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthAA37_12010	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAA37_12020	COG1744	ABC transporter substrate-binding protein PnrA-like
TthAA37_12030	COG3845	ABC transporter
TthAA37_12130	COG0438	transferase activity, transferring glycosyl groups
TthAA37_12140	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAA37_12160	COG0039	L-malate dehydrogenase activity
TthAA37_12170	COG2819	hydrolase of the alpha beta superfamily
TthAA37_12180	COG0861	Integral membrane protein TerC family
TthAA37_12200	COG0247	lactate metabolic process
TthAA37_12200	COG2181	nitrate reductase activity
TthAA37_12220	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthAA37_12230	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthAA37_12240	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthAA37_12260	COG0439	Biotin carboxylase
TthAA37_12270	COG0511	ligase activity, forming carbon-carbon bonds
TthAA37_12280	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthAA37_12320	COG0010	Belongs to the arginase family
TthAA37_12350	COG1100	Small GTP-binding protein
TthAA37_12370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAA37_12380	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAA37_12400	COG2814	Major facilitator Superfamily
TthAA37_12410	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthAA37_12420	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA37_12430	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthAA37_12440	COG0589	response to stress
TthAA37_12470	COG3335	DDE superfamily endonuclease
TthAA37_12490	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA37_12490	COG0617	tRNA 3'-terminal CCA addition
TthAA37_12490	COG0517	IMP dehydrogenase activity
TthAA37_12520	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthAA37_12530	COG0745	RESPONSE REGULATOR receiver
TthAA37_12540	COG3335	DDE superfamily endonuclease
TthAA37_12560	COG5002	protein histidine kinase activity
TthAA37_12570	COG1960	acyl-CoA dehydrogenase activity
TthAA37_12580	COG2086	electron transfer activity
TthAA37_12590	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthAA37_12610	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA37_12620	COG1573	uracil-dna glycosylase
TthAA37_12630	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAA37_12630	COG1796	DNA polymerase
TthAA37_12660	COG2309	aminopeptidase activity
TthAA37_12680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA37_12700	COG1011	Hydrolase
TthAA37_12740	COG2873	o-acetylhomoserine
TthAA37_12750	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA37_12770	COG1126	abc transporter atp-binding protein
TthAA37_12800	COG0134	indole-3-glycerol-phosphate synthase activity
TthAA37_12810	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthAA37_12830	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthAA37_12860	COG0765	amino acid transport
TthAA37_12870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthAA37_12890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthAA37_12900	COG0569	domain protein
TthAA37_12910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA37_12920	COG1426	Protein conserved in bacteria
TthAA37_12930	COG2313	pseudouridylate synthase activity
TthAA37_12950	COG3001	Fructosamine kinase
TthAA37_12960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA37_12980	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthAA37_13040	COG0012	GTP binding
TthAA37_13050	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthAA37_13070	COG0424	maF-like protein
TthAA37_13100	COG0768	penicillin binding
TthAA37_13160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthAA37_13170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA37_13190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthAA37_13230	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAA37_13250	COG1131	(ABC) transporter
TthAA37_13280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAA37_13310	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthAA37_13320	COG0440	acetolactate synthase activity
TthAA37_13330	COG0028	Belongs to the TPP enzyme family
TthAA37_13340	COG0492	ferredoxin-NADP+ reductase activity
TthAA37_13350	COG4970	Tfp pilus assembly protein FimT
TthAA37_13360	COG4970	Tfp pilus assembly protein FimT
TthAA37_13370	COG2165	general secretion pathway protein
TthAA37_13380	COG4966	pilus assembly protein PilW
TthAA37_13400	COG2165	general secretion pathway protein
TthAA37_13420	COG4636	protein conserved in cyanobacteria
TthAA37_13470	COG0180	Tryptophanyl-tRNA synthetase
TthAA37_13480	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA37_13490	COG0066	3-isopropylmalate dehydratase activity
TthAA37_13500	COG0473	3-isopropylmalate dehydrogenase activity
TthAA37_13530	COG0300	oxidoreductase activity
TthAA37_13540	COG0129	dihydroxy-acid dehydratase activity
TthAA37_13560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthAA37_13570	COG1177	transmembrane transport
TthAA37_13580	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthAA37_13590	COG3842	ATPase activity
TthAA37_13600	COG0772	Belongs to the SEDS family
TthAA37_13610	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthAA37_13620	COG2894	cell division
TthAA37_13630	COG1733	regulation of RNA biosynthetic process
TthAA37_13650	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA37_13650	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAA37_13670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA37_13680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA37_13690	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA37_13700	COG0653	protein targeting
TthAA37_13710	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthAA37_13750	COG0393	Putative heavy-metal-binding
TthAA37_13760	COG1111	helicase
TthAA37_13760	COG1205	dead DEAH box helicase
TthAA37_13800	COG0358	DNA primase activity
TthAA37_13830	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAA37_13840	COG0697	spore germination
TthAA37_13850	COG0612	Peptidase, M16
TthAA37_13860	COG0612	Peptidase, M16
TthAA37_13870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthAA37_13900	COG1394	ATPase activity, coupled to movement of substances
TthAA37_13910	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthAA37_13920	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthAA37_13930	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA37_13940	COG1527	subunit (C
TthAA37_13950	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAA37_13970	COG1269	ATP hydrolysis coupled proton transport
TthAA37_14020	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA37_14040	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAA37_14070	COG0419	ATPase involved in DNA repair
TthAA37_14080	COG0420	3'-5' exonuclease activity
TthAA37_14120	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthAA37_14130	COG2884	Cell division ATP-binding protein ftsE
TthAA37_14140	COG0793	Belongs to the peptidase S41A family
TthAA37_14150	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA37_14150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAA37_14160	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthAA37_14170	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAA37_14190	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAA37_14200	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAA37_14210	COG1129	ABC transporter
TthAA37_14220	COG0746	molybdenum cofactor guanylyltransferase activity
TthAA37_14240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA37_14280	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthAA37_14290	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAA37_14300	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthAA37_14330	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA37_14350	COG2358	TRAP transporter, solute receptor (TAXI family
TthAA37_14380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAA37_14390	COG0788	formyltetrahydrofolate deformylase activity
TthAA37_14400	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthAA37_14410	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthAA37_14420	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthAA37_14460	COG0737	Belongs to the 5'-nucleotidase family
TthAA37_14470	COG0174	glutamine synthetase
TthAA37_14490	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAA37_14530	COG0747	negative chemotaxis
TthAA37_14540	COG0601	transmembrane transport
TthAA37_14550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA37_14570	COG0285	dihydrofolate synthase activity
TthAA37_14580	COG1132	(ABC) transporter
TthAA37_14590	COG1132	(ABC) transporter
TthAA37_14600	COG0372	Belongs to the citrate synthase family
TthAA37_14610	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthAA37_14620	COG1482	cell wall glycoprotein biosynthetic process
TthAA37_14640	COG1515	deoxyribonuclease V activity
TthAA37_14660	COG0776	regulation of translation
TthAA37_14690	COG2197	response regulator
TthAA37_14700	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthAA37_14710	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthAA37_14720	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthAA37_14730	COG1324	tolerance protein
TthAA37_14740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA37_14780	COG2205	protein histidine kinase activity
TthAA37_14800	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthAA37_14870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TthAA37_14880	COG0247	lactate metabolic process
TthAA37_14890	COG1139	Iron-sulfur cluster binding protein
TthAA37_14900	COG1556	Lactate utilization protein
TthAA37_14920	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthAA37_14930	COG2815	serine threonine protein kinase
TthAA37_14930	COG0515	serine threonine protein kinase
TthAA37_14950	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthAA37_14970	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthAA37_15010	COG0473	3-isopropylmalate dehydrogenase activity
TthAA37_15060	COG1450	Type ii and iii secretion system protein
TthAA37_15070	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthAA37_15080	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthAA37_15090	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthAA37_15100	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthAA37_15100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAA37_15110	COG0736	holo-[acyl-carrier-protein] synthase activity
TthAA37_15150	COG1160	GTP binding
TthAA37_15160	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthAA37_15170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthAA37_15170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthAA37_15180	COG2814	Major facilitator Superfamily
TthAA37_15190	COG0083	homoserine kinase activity
TthAA37_15210	COG0268	Binds directly to 16S ribosomal RNA
TthAA37_15230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthAA37_15240	COG0723	plastoquinol--plastocyanin reductase activity
TthAA37_15260	COG4235	cytochrome complex assembly
TthAA37_15260	COG3088	subunit of a heme lyase
TthAA37_15270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAA37_15280	COG1138	Cytochrome C-type biogenesis protein
TthAA37_15290	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthAA37_15300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA37_15310	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAA37_15320	COG4133	protoheme IX ABC transporter activity
TthAA37_15330	COG0785	Cytochrome C biogenesis protein
TthAA37_15340	COG3258	Cytochrome c
TthAA37_15360	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA37_15390	COG3258	Cytochrome c
TthAA37_15400	COG2010	Cytochrome c
TthAA37_15410	COG0737	Belongs to the 5'-nucleotidase family
TthAA37_15420	COG2010	Cytochrome c
TthAA37_15430	COG3258	Cytochrome c
TthAA37_15470	COG2010	Cytochrome c
TthAA37_15480	COG3842	ATPase activity
TthAA37_15540	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA37_15550	COG3360	Dodecin
TthAA37_15580	COG1024	Enoyl-CoA hydratase
TthAA37_15590	COG0813	purine-nucleoside phosphorylase activity
TthAA37_15600	COG1136	(ABC) transporter
TthAA37_15610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA37_15620	COG2045	Belongs to the ComB family
TthAA37_15640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthAA37_15660	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthAA37_15680	COG0107	imidazoleglycerol-phosphate synthase activity
TthAA37_15690	COG0140	phosphoribosyl-ATP diphosphatase activity
TthAA37_15690	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthAA37_15700	COG1494	fructose-1,6-bisphosphatase
TthAA37_15710	COG0686	Belongs to the AlaDH PNT family
TthAA37_15720	COG0427	acetyl-CoA hydrolase
TthAA37_15730	COG0084	hydrolase, TatD family'
TthAA37_15740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthAA37_15760	COG0017	Asparaginyl-tRNA synthetase
TthAA37_15780	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA37_15810	COG2009	succinate dehydrogenase
TthAA37_15820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAA37_15880	COG0318	PFAM AMP-dependent synthetase and ligase
TthAA37_15890	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthAA37_15900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthAA37_15910	COG0504	CTP synthase activity
TthAA37_15950	COG0067	glutamate synthase
TthAA37_15950	COG0070	glutamate synthase
TthAA37_15950	COG0069	glutamate synthase activity
TthAA37_16000	COG3335	DDE superfamily endonuclease
TthAA37_16100	COG0840	transmembrane signaling receptor activity
TthAA37_16110	COG0305	Participates in initiation and elongation during chromosome replication
TthAA37_16130	COG0475	glutathione-regulated potassium exporter activity
TthAA37_16140	COG0517	IMP dehydrogenase activity
TthAA37_16140	COG0617	tRNA 3'-terminal CCA addition
TthAA37_16140	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAA37_16170	COG0475	glutathione-regulated potassium exporter activity
TthAA37_16180	COG0490	domain, Protein
TthAA37_16220	COG3118	belongs to the thioredoxin family
TthAA37_16300	COG0542	response to heat
TthAA37_16310	COG0789	Transcriptional regulator
TthAA37_16320	COG0484	heat shock protein binding
TthAA37_16330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthAA37_16340	COG0443	Heat shock 70 kDa protein
TthAA37_16350	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthAA37_16360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthAA37_16370	COG0616	signal peptide processing
TthAA37_16400	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthAA37_16410	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA37_16420	COG0714	Associated with various cellular activities
TthAA37_16430	COG0574	Belongs to the PEP-utilizing enzyme family
TthAA37_16430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAA37_16450	COG3850	Histidine kinase
TthAA37_16450	COG5002	protein histidine kinase activity
TthAA37_16500	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthAA37_16530	COG1011	Hydrolase
TthAA37_16550	COG3335	DDE superfamily endonuclease
TthAA37_16620	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthAA37_16650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthAA37_16670	COG0047	phosphoribosylformylglycinamidine synthase activity
TthAA37_16690	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthAA37_16700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthAA37_16710	COG0116	Belongs to the methyltransferase superfamily
TthAA37_16740	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthAA37_16750	COG0497	DNA recombination
TthAA37_16770	COG0604	alcohol dehydrogenase
TthAA37_16810	COG0585	pseudouridine synthase activity
TthAA37_16860	COG1595	DNA-templated transcription, initiation
TthAA37_16870	COG0557	exoribonuclease II activity
TthAA37_16880	COG0538	isocitrate dehydrogenase activity
TthAA37_16890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAA37_16890	COG2022	thiamine diphosphate biosynthetic process
TthAA37_16920	COG0037	tRNA processing
TthAA37_16920	COG0590	tRNA wobble adenosine to inosine editing
TthAA37_16960	COG2050	protein possibly involved in aromatic compounds catabolism
TthAA37_16980	COG0322	excinuclease ABC activity
TthAA37_16990	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA37_17000	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAA37_17010	COG1854	S-ribosylhomocysteine lyase activity
TthAA37_17040	COG0519	Catalyzes the synthesis of GMP from XMP
TthAA37_17040	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAA37_17050	COG4636	protein conserved in cyanobacteria
TthAA37_17060	COG4274	PFAM GYD family protein
TthAA37_17070	COG0346	lactoylglutathione lyase activity
TthAA37_17080	COG0328	RNA-DNA hybrid ribonuclease activity
TthAA37_17090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAA37_17100	COG2095	MarC family integral membrane protein
TthAA37_17110	COG1438	arginine binding
TthAA37_17120	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthAA37_17130	COG1758	RNA polymerase activity
TthAA37_17140	COG0194	GDP metabolic process
TthAA37_17180	COG3335	DDE superfamily endonuclease
TthAA37_17200	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthAA37_17210	COG2385	sporulation resulting in formation of a cellular spore
TthAA37_17220	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthAA37_17240	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAA37_17320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA37_17330	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAA37_17340	COG1012	belongs to the aldehyde dehydrogenase family
TthAA37_17350	COG0506	proline dehydrogenase activity
TthAA37_17380	COG0156	8-amino-7-oxononanoate synthase activity
TthAA37_17390	COG0732	type I restriction modification DNA specificity domain
TthAA37_17390	COG0827	DNA restriction-modification system
TthAA37_17410	COG0187	DNA topoisomerase II activity
TthAA37_17420	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthAA37_17430	COG0193	aminoacyl-tRNA hydrolase activity
TthAA37_17440	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthAA37_17490	COG2815	serine threonine protein kinase
TthAA37_17490	COG0515	serine threonine protein kinase
TthAA37_17500	COG0631	protein serine/threonine phosphatase activity
TthAA37_17520	COG2814	Major facilitator Superfamily
TthAA37_17530	COG0113	porphobilinogen synthase activity
TthAA37_17540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthAA37_17550	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthAA37_17600	COG4946	Tricorn protease homolog
TthAA37_17600	COG0823	Involved in the tonB-independent uptake of proteins
TthAA37_17600	COG1506	peptidase
TthAA37_17610	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthAA37_17620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthAA37_17660	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthAA37_17670	COG1011	Hydrolase
TthAA37_17720	COG0537	adenosine 5'-monophosphoramidase activity
TthAA37_17730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAA37_17740	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthAA37_17750	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthAA37_17760	COG0071	Belongs to the small heat shock protein (HSP20) family
TthAA37_17770	COG2897	thiosulfate sulfurtransferase activity
TthAA37_17780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAA37_17800	COG1764	response to oxidative stress
TthAA37_17830	COG1840	ABC-type Fe3 transport system, periplasmic component
TthAA37_17850	COG3842	ATPase activity
TthAA37_17860	COG0101	tRNA pseudouridine synthase activity
TthAA37_17870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAA37_17880	COG0601	transmembrane transport
TthAA37_17920	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAA37_17950	COG1166	arginine decarboxylase activity
TthAA37_17970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthAA37_17980	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthAA37_17990	COG1611	Belongs to the LOG family
TthAA37_18000	COG1193	negative regulation of DNA recombination
TthAA37_18020	COG0366	Alpha amylase catalytic
TthAA37_18110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthAA37_18120	COG0142	geranyltranstransferase activity
TthAA37_18140	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthAA37_18200	COG0203	ribosomal protein L17
TthAA37_18210	COG0202	RNA polymerase activity
TthAA37_18220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthAA37_18230	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthAA37_18240	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthAA37_18250	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthAA37_18270	COG0563	adenylate kinase activity
TthAA37_18280	COG0201	protein transport
TthAA37_18330	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthAA37_18340	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthAA37_18350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthAA37_18400	COG0255	Belongs to the universal ribosomal protein uL29 family
TthAA37_18410	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthAA37_18420	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthAA37_18440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthAA37_18450	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthAA37_18460	COG0089	rRNA binding
TthAA37_18470	COG0088	Forms part of the polypeptide exit tunnel
TthAA37_18490	COG0051	transcription antitermination factor activity, RNA binding
TthAA37_18500	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAA37_18510	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAA37_18520	COG0049	tRNA binding
TthAA37_18550	COG0442	prolyl-tRNA aminoacylation
TthAA37_18570	COG1115	amino acid carrier protein
TthAA37_18610	COG1489	DNA binding
TthAA37_18660	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthAA37_18700	COG0432	Pfam Uncharacterised protein family UPF0047
TthAA37_18710	COG3253	May function as heme-dependent peroxidase
TthAA37_18720	COG0668	transmembrane transport
TthAA37_18740	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthAA37_18750	COG2217	Heavy metal translocating P-type atpase
TthAA37_18790	COG0745	RESPONSE REGULATOR receiver
TthAA37_18800	COG2205	protein histidine kinase activity
TthAA37_18840	COG2226	methyltransferase
TthAA37_18880	COG2132	Multicopper oxidase
TthAA37_18900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthAA37_18910	COG0822	iron-sulfur transferase activity
TthAA37_18950	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthAA37_18970	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthAA37_18980	COG0284	orotidine-5'-phosphate decarboxylase activity
TthAA37_19000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA37_19020	COG0416	fatty acid biosynthetic process
TthAA37_19030	COG3118	belongs to the thioredoxin family
TthAA37_19040	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAA37_19050	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthAA37_19070	COG0438	transferase activity, transferring glycosyl groups
TthAA37_19100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthAA37_19110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAA37_19120	COG3706	GGDEF domain
TthAA37_19190	COG0437	4 iron, 4 sulfur cluster binding
TthAA37_19220	COG0825	malonyl-CoA metabolic process
TthAA37_19230	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthAA37_19300	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthAA37_19350	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthAA37_19360	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthAA37_19370	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthAA37_19380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthAA37_19400	COG4974	Belongs to the 'phage' integrase family
TthAA37_19580	COG0315	cyclic pyranopterin monophosphate synthase activity
TthAA37_19590	COG2860	membrane
TthAA37_19610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthAA37_19640	COG0477	Major facilitator Superfamily
TthAA37_19650	COG1694	Mazg nucleotide pyrophosphohydrolase
TthAA37_19660	COG1803	Methylglyoxal synthase
TthAA37_19680	COG0301	tRNA thio-modification
TthAA37_19690	COG0154	amidase activity
TthAA37_19700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthAA37_19750	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthAA37_19760	COG1607	acyl-coa hydrolase
TthAA37_19780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthAA37_19790	COG4149	molybdate abc transporter
TthAA37_19800	COG1840	ABC-type Fe3 transport system, periplasmic component
TthAA37_19830	COG0235	Class ii aldolase
TthAA37_19840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthAA37_19850	COG0085	RNA polymerase activity
TthAA37_19870	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthAA37_19880	COG1077	Cell shape determining protein MreB Mrl
TthAA37_19890	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthAA37_19890	COG1418	mRNA catabolic process
TthAA37_19900	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthAA37_19910	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthAA37_19920	COG1058	Belongs to the CinA family
TthAA37_19920	COG1546	Belongs to the CinA family
TthAA37_19930	COG0354	folic acid binding
TthAA37_19960	COG4948	Mandelate Racemase Muconate Lactonizing
TthAA37_19990	COG1175	transmembrane transport
TthAA37_20010	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthAA37_20030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAA37_20050	COG0577	efflux transmembrane transporter activity
TthAA37_20050	COG1136	(ABC) transporter
TthAA37_20060	COG4181	ATPase activity
TthAA37_20070	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAA37_20100	COG0396	ATPase activity
TthAA37_20110	COG0719	Fe-S assembly protein
TthAA37_20120	COG0719	Fe-S assembly protein
TthAA37_20130	COG2146	nitrite reductase [NAD(P)H] activity
TthAA37_20150	COG0512	Glutamine amidotransferase of anthranilate synthase
TthAA37_20160	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAA37_20230	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAA37_20240	COG2226	methyltransferase
TthAA37_20250	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAA37_20260	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAA37_20290	COG1774	PSP1 C-terminal conserved region
TthAA37_20310	COG0470	DNA polymerase III
TthAA37_20400	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthAA37_20430	COG0302	gtp cyclohydrolase
TthAA37_20480	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthAA37_20500	COG0395	ABC-type sugar transport system, permease component
TthAA37_20510	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthAA37_20520	COG1131	(ABC) transporter
TthAA37_20560	COG0556	nucleotide-excision repair
TthAA37_20570	COG0497	DNA recombination
TthAA37_20580	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthAA37_20590	COG0445	tRNA wobble uridine modification
TthAA37_20630	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthAA37_20630	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAA37_20640	COG1543	Belongs to the glycosyl hydrolase 57 family
TthAA37_20650	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA37_20660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAA37_20670	COG0189	ligase activity
TthAA37_20700	COG0066	3-isopropylmalate dehydratase activity
TthAA37_20710	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAA37_20740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAA37_20750	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthAA37_20760	COG1960	acyl-CoA dehydrogenase activity
TthAA37_20770	COG0163	prenyltransferase activity
TthAA37_20860	COG3335	DDE superfamily endonuclease
TthAA37_20880	COG2096	Adenosyltransferase
TthAA37_20910	COG2801	Transposase and inactivated derivatives
TthAA37_20950	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthAA37_20960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthAA37_20980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthAA37_20990	COG0723	plastoquinol--plastocyanin reductase activity
TthAA37_21040	COG1653	transport
TthAA37_21050	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthAA37_21060	COG1960	acyl-CoA dehydrogenase activity
TthAA37_21080	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthAA37_21120	COG0393	Putative heavy-metal-binding
TthAA37_21140	COG3956	TIGRFAM MazG family protein
TthAA37_21160	COG0693	protein deglycase activity
TthAA37_21170	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAA37_21190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthAA37_21200	COG1937	Protein conserved in bacteria
TthAA37_21220	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthAA37_21220	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthAA37_21230	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthAA37_21260	COG3335	DDE superfamily endonuclease
TthAA37_21300	COG0205	6-phosphofructokinase activity
TthAA37_21310	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthAA37_21330	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthAA37_21360	COG0658	competence protein
TthAA37_21360	COG2333	competence protein COMEC
TthAA37_21370	COG1475	DNA binding
TthAA37_21380	COG1192	Involved in chromosome partitioning
TthAA37_21390	COG0357	Ribosomal RNA small subunit methyltransferase G
TthAA37_21410	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthAA37_21420	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthAA37_21430	COG0588	phosphoglycerate mutase activity
TthAA37_21460	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthAA37_21480	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TthAA37_21490	COG1797	cobyrinic acid a,c-diamide synthase activity
TthAA37_21500	COG2211	Major facilitator Superfamily
TthAA37_21540	COG2211	Major facilitator Superfamily
TthAA37_21560	COG0739	heme binding
TthAA37_21840	COG5002	protein histidine kinase activity
TthAA37_21840	COG3850	Histidine kinase
TthAA37_21850	COG0745	RESPONSE REGULATOR receiver
TthAA37_21990	COG2329	Antibiotic biosynthesis monooxygenase
TthAA37_22030	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAA37_22050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAA37_22060	COG0642	Histidine kinase
TthAA37_22070	COG0745	RESPONSE REGULATOR receiver
TthAA37_22080	COG0745	RESPONSE REGULATOR receiver
TthAA37_22090	COG0671	phosphoesterase, PA-phosphatase related
TthAA37_22150	COG0730	response to heat
TthAA37_22180	COG0363	glucosamine-6-phosphate deaminase activity
TthAA37_22190	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TthAA37_22200	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TthAA37_22290	COG2010	Cytochrome c
TthAA37_22300	COG0745	RESPONSE REGULATOR receiver
TthAA37_22310	COG2205	protein histidine kinase activity
TthAA37_22450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthAA37_22460	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TthAA37_22520	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthAA37_22530	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TthAA37_22570	COG1857	crispr-associated protein
TthAA37_22650	COG2814	Major facilitator Superfamily
TthAA37_22670	COG2151	metal-sulfur cluster biosynthetic enzyme
TthAA37_22740	COG2181	nitrate reductase activity
TthAA37_22770	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TthAA37_22780	COG2010	Cytochrome c
TthAA37_22800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA37_22820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TthAA37_22870	COG1252	NADH dehydrogenase
TthAA37_22880	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAA37_22900	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAA37_22950	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthAA37_23000	COG2010	Cytochrome c
TthAA37_23010	COG0535	radical SAM domain protein
TthAA37_23040	COG3256	nitric oxide reductase
TthAA37_23140	COG1192	Involved in chromosome partitioning
TthAA37_23150	COG1475	DNA binding
TthAA37_23190	COG4966	pilus assembly protein PilW
TthAA37_23240	COG3345	alpha-galactosidase
TthAA37_23250	COG1085	galactose-1-phosphate uridylyltransferase
TthAA37_23310	COG1304	FMN binding
TthAA37_23330	COG1487	ribonuclease activity
TthAA37_23380	COG2124	cytochrome p450
TthAA37_23410	COG1562	ergosterol biosynthetic process
TthAA37_23430	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAA37_23460	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAA37_23490	COG1175	transmembrane transport
TthAA37_23520	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_23550	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_23560	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAA37_23580	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthAA37_23590	COG1414	Transcriptional regulator
TthAA37_23620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA37_23660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TthAA37_23670	COG1785	Belongs to the alkaline phosphatase family
TthAA37_23680	COG1492	cobalamin metabolic process
TthAA37_23740	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TthAA37_23750	COG0778	Nitroreductase
TthAA37_23760	COG1648	precorrin-2 dehydrogenase activity
TthAA37_23760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAA37_23830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthAA37_23920	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthAA37_23970	COG0482	sulfurtransferase activity
TthAA37_24000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthAA37_24030	COG1607	acyl-coa hydrolase
TthAA37_24050	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthAA37_24310	COG0497	DNA recombination
TthAA37_24320	COG3854	ATPases associated with a variety of cellular activities
TthAA37_24470	COG2002	toxin-antitoxin pair type II binding
TthAA37_24550	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthAA37_24650	COG1349	DNA-binding transcription factor activity
TthAA37_24660	COG3718	enzyme involved in inositol metabolism
TthAA37_24670	COG0673	inositol 2-dehydrogenase activity
TthAA37_24690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAA37_24710	COG3962	Belongs to the TPP enzyme family
TthAA37_24720	COG1129	ABC transporter
TthAA37_24730	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthAA37_24740	COG1012	belongs to the aldehyde dehydrogenase family
TthAA37_24800	COG1192	Involved in chromosome partitioning
TthAA37_24810	COG1475	DNA binding
TthAA37_24820	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthAA37_24910	COG1175	transmembrane transport
TthAA37_24920	COG2801	Transposase and inactivated derivatives
TthAA37_25170	COG3328	transposase activity
TthAA37_25190	COG1175	transmembrane transport
TthAA37_25200	COG0395	ABC-type sugar transport system, permease component
TthAA37_25240	COG3842	ATPase activity
TthAA37_25270	COG1653	transport
TthAA37_25280	COG1175	transmembrane transport
TthAA37_25290	COG0395	ABC-type sugar transport system, permease component
TthAA37_25300	COG1692	metallophosphoesterase
TthAA37_25330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAA37_25360	COG1012	belongs to the aldehyde dehydrogenase family
TthAA37_25360	COG2030	dehydratase
TthAA37_25380	COG1028	Short-chain dehydrogenase reductase Sdr
TthAA37_t00330	COG0544	peptidyl-prolyl cis-trans isomerase activity