locus-tag	class	description
TthAK1_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthAK1_00020	COG0592	DNA-directed DNA polymerase activity
TthAK1_00030	COG0148	phosphopyruvate hydratase activity
TthAK1_00040	COG0469	pyruvate kinase activity
TthAK1_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAK1_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthAK1_00090	COG1842	Phage shock protein A
TthAK1_00150	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthAK1_00160	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAK1_00180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthAK1_00190	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthAK1_00200	COG1496	oxidoreductase activity
TthAK1_00210	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAK1_00220	COG1278	Cold shock
TthAK1_00250	COG1653	transport
TthAK1_00280	COG0033	Phosphoglucomutase
TthAK1_00300	COG2814	Major facilitator Superfamily
TthAK1_00320	COG0517	IMP dehydrogenase activity
TthAK1_00320	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthAK1_00330	COG1950	PFAM Membrane protein of
TthAK1_00340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthAK1_00360	COG0181	hydroxymethylbilane synthase activity
TthAK1_00380	COG0285	dihydrofolate synthase activity
TthAK1_00390	COG0436	Aminotransferase
TthAK1_00400	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthAK1_00450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthAK1_00460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthAK1_00470	COG1993	acr, cog1993
TthAK1_00480	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthAK1_00500	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAK1_00520	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthAK1_00530	COG1335	isochorismatase
TthAK1_00540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthAK1_00570	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthAK1_00580	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthAK1_00620	COG1660	Displays ATPase and GTPase activities
TthAK1_00630	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthAK1_00720	COG3335	DDE superfamily endonuclease
TthAK1_00740	COG1845	cytochrome c oxidase, subunit III
TthAK1_00740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAK1_00750	COG2010	Cytochrome c
TthAK1_00750	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAK1_00760	COG0109	protoheme IX farnesyltransferase activity
TthAK1_00760	COG1612	heme a metabolic process
TthAK1_00790	COG0343	queuine tRNA-ribosyltransferase activity
TthAK1_00800	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthAK1_00810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthAK1_00920	COG1940	carbohydrate kinase activity
TthAK1_00940	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAK1_00950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAK1_00960	COG0589	response to stress
TthAK1_00970	COG1611	Belongs to the LOG family
TthAK1_00990	COG1011	Hydrolase
TthAK1_01000	COG0632	four-way junction helicase activity
TthAK1_01010	COG1024	Enoyl-CoA hydratase
TthAK1_01030	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAK1_01100	COG0137	argininosuccinate synthase activity
TthAK1_01110	COG0165	Argininosuccinate lyase
TthAK1_01130	COG0505	Belongs to the CarA family
TthAK1_01150	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthAK1_01160	COG0166	Belongs to the GPI family
TthAK1_01190	COG0714	Associated with various cellular activities
TthAK1_01220	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAK1_01230	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthAK1_01240	COG0459	protein refolding
TthAK1_01250	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthAK1_01260	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthAK1_01280	COG0778	Nitroreductase
TthAK1_01290	COG1388	LysM domain
TthAK1_01290	COG0791	NLP P60 protein
TthAK1_01310	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthAK1_01330	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthAK1_01340	COG0581	inorganic phosphate transmembrane transporter activity
TthAK1_01350	COG0573	inorganic phosphate transmembrane transporter activity
TthAK1_01370	COG0482	sulfurtransferase activity
TthAK1_01390	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthAK1_01400	COG0735	belongs to the Fur family
TthAK1_01430	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthAK1_01440	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAK1_01450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthAK1_01460	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthAK1_01470	COG0250	Participates in transcription elongation, termination and antitermination
TthAK1_01490	COG0081	regulation of translation
TthAK1_01510	COG0629	single-stranded DNA binding
TthAK1_01520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthAK1_01530	COG0359	binds to the 23S rRNA
TthAK1_01570	COG0300	oxidoreductase activity
TthAK1_01580	COG0321	lipoyl(octanoyl) transferase activity
TthAK1_01590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthAK1_01640	COG1476	TRANSCRIPTIONal
TthAK1_01680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthAK1_01710	COG1598	PFAM Uncharacterised protein family UPF0150
TthAK1_01720	COG0022	dehydrogenase e1 component
TthAK1_01730	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthAK1_01740	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthAK1_01790	COG2226	methyltransferase
TthAK1_01800	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthAK1_01820	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthAK1_01830	COG1187	pseudouridine synthase activity
TthAK1_01850	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthAK1_01860	COG0686	Belongs to the AlaDH PNT family
TthAK1_01880	COG1461	Dihydroxyacetone kinase
TthAK1_01910	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthAK1_01920	COG0222	ribosome binding
TthAK1_01930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthAK1_01950	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthAK1_01980	COG0697	spore germination
TthAK1_02000	COG3177	Filamentation induced by cAMP protein fic
TthAK1_02020	COG0243	molybdopterin cofactor binding
TthAK1_02040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthAK1_02060	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAK1_02090	COG0477	Major facilitator Superfamily
TthAK1_02120	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthAK1_02140	COG0105	UTP biosynthetic process
TthAK1_02150	COG0631	protein serine/threonine phosphatase activity
TthAK1_02160	COG0583	DNA-binding transcription factor activity
TthAK1_02180	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthAK1_02240	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthAK1_02260	COG1278	Cold shock
TthAK1_02270	COG0484	heat shock protein binding
TthAK1_02280	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthAK1_02290	COG1968	undecaprenyl-diphosphatase activity
TthAK1_02300	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthAK1_02310	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthAK1_02340	COG1309	transcriptional regulator
TthAK1_02350	COG4242	Belongs to the peptidase S51 family
TthAK1_02380	COG0802	atpase or kinase
TthAK1_02390	COG0539	negative regulation of cytoplasmic translation
TthAK1_02400	COG0495	leucyl-tRNA aminoacylation
TthAK1_02440	COG1902	pentaerythritol trinitrate reductase activity
TthAK1_02490	COG2414	aldehyde ferredoxin oxidoreductase
TthAK1_02510	COG2165	general secretion pathway protein
TthAK1_02530	COG2165	general secretion pathway protein
TthAK1_02590	COG1459	type II secretion system
TthAK1_02610	COG1187	pseudouridine synthase activity
TthAK1_02630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAK1_02640	COG0745	RESPONSE REGULATOR receiver
TthAK1_02650	COG4191	Histidine kinase
TthAK1_02660	COG0704	Plays a role in the regulation of phosphate uptake
TthAK1_02670	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthAK1_02690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthAK1_02710	COG0515	serine threonine protein kinase
TthAK1_02710	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthAK1_02750	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthAK1_02760	COG0300	oxidoreductase activity
TthAK1_02790	COG0717	Belongs to the dCTP deaminase family
TthAK1_02800	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthAK1_02810	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthAK1_02820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthAK1_02840	COG0583	DNA-binding transcription factor activity
TthAK1_02850	COG3546	catalase activity
TthAK1_02860	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAK1_02860	COG0758	DNA mediated transformation
TthAK1_02870	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthAK1_02890	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAK1_02910	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthAK1_02940	COG0442	prolyl-tRNA aminoacylation
TthAK1_02950	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthAK1_02990	COG0303	'Molybdopterin
TthAK1_03000	COG0513	Belongs to the DEAD box helicase family
TthAK1_03010	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthAK1_03030	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthAK1_03070	COG2070	2-Nitropropane dioxygenase
TthAK1_03100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthAK1_03110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAK1_03120	COG0018	arginyl-trna synthetase
TthAK1_03130	COG1007	ATP synthesis coupled electron transport
TthAK1_03140	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAK1_03150	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthAK1_03160	COG0713	ATP synthesis coupled electron transport
TthAK1_03170	COG0839	Belongs to the complex I subunit 6 family
TthAK1_03180	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAK1_03190	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthAK1_03200	COG1034	ATP synthesis coupled electron transport
TthAK1_03210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthAK1_03220	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthAK1_03230	COG0649	NAD binding
TthAK1_03240	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAK1_03250	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAK1_03260	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthAK1_03270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthAK1_03290	COG4712	double-strand break repair protein
TthAK1_03320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthAK1_03350	COG0135	phosphoribosylanthranilate isomerase activity
TthAK1_03370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthAK1_03390	COG2720	vancomycin resistance protein
TthAK1_03400	COG1126	abc transporter atp-binding protein
TthAK1_03460	COG0277	FAD linked oxidase domain protein
TthAK1_03490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthAK1_03500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthAK1_03530	COG0314	molybdopterin synthase activity
TthAK1_03540	COG1420	regulation of RNA biosynthetic process
TthAK1_03550	COG0347	Belongs to the P(II) protein family
TthAK1_03560	COG0004	ammonium transporteR
TthAK1_03580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthAK1_03600	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAK1_03610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
TthAK1_03610	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAK1_03630	COG1597	lipid kinase activity
TthAK1_03640	COG0436	Aminotransferase
TthAK1_03660	COG0475	glutathione-regulated potassium exporter activity
TthAK1_03660	COG0569	domain protein
TthAK1_03680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthAK1_03700	COG0277	FAD linked oxidase domain protein
TthAK1_03750	COG0667	Aldo Keto reductase
TthAK1_03810	COG1067	ATP-dependent peptidase activity
TthAK1_03820	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthAK1_03840	COG0745	RESPONSE REGULATOR receiver
TthAK1_03860	COG3335	DDE superfamily endonuclease
TthAK1_03870	COG2105	PFAM AIG2 family protein
TthAK1_03880	COG0297	glycogen (starch) synthase activity
TthAK1_03900	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthAK1_03910	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthAK1_03940	COG0142	geranyltranstransferase activity
TthAK1_03960	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthAK1_03970	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_03980	COG0492	ferredoxin-NADP+ reductase activity
TthAK1_04000	COG0792	nuclease activity
TthAK1_04010	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthAK1_04040	COG1175	transmembrane transport
TthAK1_04050	COG0395	ABC-type sugar transport system, permease component
TthAK1_04110	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthAK1_04120	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthAK1_04130	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthAK1_04140	COG0805	protein transport
TthAK1_04150	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAK1_04150	COG1605	Chorismate mutase
TthAK1_04260	COG1063	alcohol dehydrogenase
TthAK1_04320	COG2255	four-way junction helicase activity
TthAK1_04330	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthAK1_04340	COG0564	pseudouridine synthase activity
TthAK1_04370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthAK1_04380	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthAK1_04390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthAK1_04400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthAK1_04420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthAK1_04430	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthAK1_04440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthAK1_04510	COG0778	Nitroreductase
TthAK1_04530	COG0778	Nitroreductase
TthAK1_04560	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthAK1_04570	COG0131	Imidazoleglycerol-phosphate dehydratase
TthAK1_04580	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthAK1_04590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthAK1_04600	COG0517	IMP dehydrogenase activity
TthAK1_04600	COG0516	GMP reductase activity
TthAK1_04630	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthAK1_04640	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAK1_04670	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAK1_04710	COG0706	membrane insertase activity
TthAK1_04720	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthAK1_04730	COG0594	ribonuclease P activity
TthAK1_04750	COG1022	Amp-dependent synthetase and ligase
TthAK1_04800	COG1121	(ABC) transporter
TthAK1_04810	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthAK1_04820	COG1959	2 iron, 2 sulfur cluster binding
TthAK1_04830	COG1104	cysteine desulfurase activity
TthAK1_04840	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthAK1_04850	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthAK1_04880	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_04920	COG0492	ferredoxin-NADP+ reductase activity
TthAK1_04930	COG0604	alcohol dehydrogenase
TthAK1_04930	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_04930	COG3321	synthase
TthAK1_04960	COG0747	negative chemotaxis
TthAK1_04970	COG0601	transmembrane transport
TthAK1_04980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAK1_05020	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAK1_05020	COG0617	tRNA 3'-terminal CCA addition
TthAK1_05020	COG0517	IMP dehydrogenase activity
TthAK1_05030	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthAK1_05040	COG2104	thiamine diphosphate biosynthetic process
TthAK1_05050	COG0037	tRNA processing
TthAK1_05080	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthAK1_05100	COG4176	ABC-type proline glycine betaine transport system permease component
TthAK1_05110	COG4175	Glycine betaine
TthAK1_05110	COG3448	diguanylate cyclase activity
TthAK1_05120	COG0366	Alpha amylase catalytic
TthAK1_05130	COG2226	methyltransferase
TthAK1_05140	COG2226	methyltransferase
TthAK1_05150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthAK1_05170	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthAK1_05180	COG0460	homoserine dehydrogenase
TthAK1_05200	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthAK1_05270	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthAK1_05310	COG0247	lactate metabolic process
TthAK1_05320	COG0277	FAD linked oxidase domain protein
TthAK1_05330	COG0277	FAD linked oxidase domain protein
TthAK1_05340	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthAK1_05350	COG1414	Transcriptional regulator
TthAK1_05360	COG0789	Transcriptional regulator
TthAK1_05380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAK1_05390	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAK1_05460	COG0861	Integral membrane protein TerC family
TthAK1_05480	COG2151	metal-sulfur cluster biosynthetic enzyme
TthAK1_05490	COG0281	malic enzyme
TthAK1_05520	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthAK1_05530	COG0509	glycine decarboxylation via glycine cleavage system
TthAK1_05540	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAK1_05550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthAK1_05560	COG0196	riboflavin kinase activity
TthAK1_05610	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthAK1_05620	COG2813	Specifically methylates the guanine in position
TthAK1_05630	COG0527	aspartate kinase activity
TthAK1_05690	COG4956	integral membrane protein (PIN domain superfamily)
TthAK1_05700	COG4956	integral membrane protein (PIN domain superfamily)
TthAK1_05710	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthAK1_05720	COG0542	response to heat
TthAK1_05730	COG0423	glycine-tRNA ligase activity
TthAK1_05750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthAK1_05800	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthAK1_05800	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAK1_05820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthAK1_05840	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthAK1_05860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAK1_05870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAK1_05880	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthAK1_05890	COG0114	fumarate hydratase activity
TthAK1_05900	COG0183	Belongs to the thiolase family
TthAK1_05930	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthAK1_05940	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthAK1_05970	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthAK1_05980	COG1254	Belongs to the acylphosphatase family
TthAK1_06010	COG1063	alcohol dehydrogenase
TthAK1_06020	COG2133	pyrroloquinoline quinone binding
TthAK1_06040	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthAK1_06050	COG0154	amidase activity
TthAK1_06100	COG0572	uridine kinase
TthAK1_06110	COG3842	ATPase activity
TthAK1_06140	COG4475	Protein of unknown function (DUF436)
TthAK1_06180	COG1595	DNA-templated transcription, initiation
TthAK1_06320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAK1_06330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthAK1_06340	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthAK1_06370	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthAK1_06380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthAK1_06390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthAK1_06420	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_06430	COG0318	PFAM AMP-dependent synthetase and ligase
TthAK1_06440	COG1012	belongs to the aldehyde dehydrogenase family
TthAK1_06440	COG2030	dehydratase
TthAK1_06450	COG1960	acyl-CoA dehydrogenase activity
TthAK1_06480	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthAK1_06490	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthAK1_06500	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthAK1_06520	COG3870	Protein conserved in bacteria
TthAK1_06530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthAK1_06550	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthAK1_06560	COG0740	serine-type endopeptidase activity
TthAK1_06570	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthAK1_06580	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthAK1_06590	COG1410	methionine synthase
TthAK1_06590	COG0646	methionine synthase
TthAK1_06600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAK1_06650	COG1692	metallophosphoesterase
TthAK1_06660	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthAK1_06670	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthAK1_06700	COG0437	4 iron, 4 sulfur cluster binding
TthAK1_06710	COG0243	molybdopterin cofactor binding
TthAK1_06710	COG3383	formate dehydrogenase (NAD+) activity
TthAK1_06730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthAK1_06740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthAK1_06890	COG0438	transferase activity, transferring glycosyl groups
TthAK1_06940	COG0529	Catalyzes the synthesis of activated sulfate
TthAK1_06960	COG2046	Belongs to the sulfate adenylyltransferase family
TthAK1_06990	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAK1_07030	COG0489	protein tyrosine kinase activity
TthAK1_07050	COG2264	protein methyltransferase activity
TthAK1_07060	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthAK1_07130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthAK1_07140	COG2046	Belongs to the sulfate adenylyltransferase family
TthAK1_07150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAK1_07150	COG1648	precorrin-2 dehydrogenase activity
TthAK1_07160	COG0730	response to heat
TthAK1_07170	COG0175	sulfate reduction
TthAK1_07180	COG1648	precorrin-2 dehydrogenase activity
TthAK1_07180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAK1_07190	COG1587	Uroporphyrinogen-III synthase
TthAK1_07200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthAK1_07290	COG0352	thiamine-phosphate diphosphorylase activity
TthAK1_07300	COG2104	thiamine diphosphate biosynthetic process
TthAK1_07310	COG2022	thiamine diphosphate biosynthetic process
TthAK1_07320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAK1_07320	COG2022	thiamine diphosphate biosynthetic process
TthAK1_07330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthAK1_07340	COG0477	Major facilitator Superfamily
TthAK1_07350	COG0351	phosphomethylpyrimidine kinase
TthAK1_07410	COG1175	transmembrane transport
TthAK1_07430	COG1940	carbohydrate kinase activity
TthAK1_07440	COG0183	Belongs to the thiolase family
TthAK1_07470	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_07510	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAK1_07540	COG2030	dehydratase
TthAK1_07560	COG0596	Alpha beta hydrolase
TthAK1_07570	COG0318	PFAM AMP-dependent synthetase and ligase
TthAK1_07600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAK1_07600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthAK1_07620	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthAK1_07640	COG0195	Participates in both transcription termination and antitermination
TthAK1_07650	COG0779	Required for maturation of 30S ribosomal subunits
TthAK1_07660	COG0739	heme binding
TthAK1_07670	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthAK1_07680	COG0640	Transcriptional regulator
TthAK1_07690	COG2217	Heavy metal translocating P-type atpase
TthAK1_07700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TthAK1_07710	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthAK1_07720	COG0017	Asparaginyl-tRNA synthetase
TthAK1_07730	COG0561	phosphatase activity
TthAK1_07740	COG0384	phenazine biosynthesis protein PhzF
TthAK1_07760	COG0124	histidyl-tRNA synthetase
TthAK1_07780	COG3842	ATPase activity
TthAK1_07820	COG1573	uracil-dna glycosylase
TthAK1_07860	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthAK1_07870	COG0519	Catalyzes the synthesis of GMP from XMP
TthAK1_07870	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAK1_07890	COG1316	TRANSCRIPTIONal
TthAK1_07900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthAK1_07990	COG0295	cytidine deaminase activity
TthAK1_08010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthAK1_08030	COG1760	l-serine dehydratase
TthAK1_08050	COG0481	GTPase activity
TthAK1_08070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthAK1_08080	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthAK1_08100	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_08150	COG0405	Gamma-glutamyltransferase
TthAK1_08170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthAK1_08180	COG2873	o-acetylhomoserine
TthAK1_08210	COG1063	alcohol dehydrogenase
TthAK1_08230	COG3191	aminopeptidase activity
TthAK1_08240	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthAK1_08260	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAK1_08270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAK1_08280	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAK1_08290	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthAK1_08310	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthAK1_08330	COG0167	dihydroorotate dehydrogenase activity
TthAK1_08410	COG0730	response to heat
TthAK1_08420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthAK1_08440	COG0312	modulator of DNA gyrase
TthAK1_08460	COG1960	acyl-CoA dehydrogenase activity
TthAK1_08470	COG0456	acetyltransferase
TthAK1_08490	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthAK1_08500	COG0009	L-threonylcarbamoyladenylate synthase
TthAK1_08510	COG1459	type II secretion system
TthAK1_08540	COG0277	FAD linked oxidase domain protein
TthAK1_08560	COG0287	Prephenate dehydrogenase
TthAK1_08570	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthAK1_08580	COG2514	catechol 2,3-dioxygenase activity
TthAK1_08590	COG2353	YceI-like domain
TthAK1_08600	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAK1_08610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAK1_08650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAK1_08660	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthAK1_08680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthAK1_08690	COG0151	Belongs to the GarS family
TthAK1_08700	COG5002	protein histidine kinase activity
TthAK1_08700	COG2176	DNA-directed DNA polymerase activity
TthAK1_08760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthAK1_08780	COG0217	transcriptional regulatory protein
TthAK1_08790	COG4651	solute:proton antiporter activity
TthAK1_08790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthAK1_08800	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthAK1_08810	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthAK1_08820	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAK1_08830	COG1674	ftsk spoiiie
TthAK1_08860	COG0517	IMP dehydrogenase activity
TthAK1_08880	COG0617	tRNA 3'-terminal CCA addition
TthAK1_08880	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAK1_08880	COG3620	sequence-specific DNA binding
TthAK1_08900	COG1994	Peptidase M50
TthAK1_08910	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthAK1_08930	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAK1_08960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthAK1_08970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAK1_08980	COG2719	SpoVR family
TthAK1_08990	COG2718	Belongs to the UPF0229 family
TthAK1_09000	COG2766	serine protein kinase
TthAK1_09050	COG2137	regulation of response to DNA damage stimulus
TthAK1_09070	COG2359	stage V sporulation protein S
TthAK1_09080	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAK1_09090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthAK1_09110	COG0463	Glycosyl transferase, family 2
TthAK1_09120	COG0750	zinc metalloprotease
TthAK1_09130	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthAK1_09140	COG0575	Belongs to the CDS family
TthAK1_09150	COG0233	cytoplasmic translational termination
TthAK1_09160	COG0528	UMP kinase activity
TthAK1_09170	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthAK1_09180	COG0052	Belongs to the universal ribosomal protein uS2 family
TthAK1_09190	COG0582	viral genome integration into host DNA
TthAK1_09280	COG1598	PFAM Uncharacterised protein family UPF0150
TthAK1_09360	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthAK1_09370	COG0494	nUDIX hydrolase
TthAK1_09450	COG0402	S-adenosylhomocysteine deaminase activity
TthAK1_09470	COG4948	Mandelate Racemase Muconate Lactonizing
TthAK1_09480	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthAK1_09490	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthAK1_09500	COG1811	Na channel or pump
TthAK1_09510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAK1_09510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthAK1_09540	COG1215	transferase activity, transferring glycosyl groups
TthAK1_09560	COG1216	Glycosyl transferase, family 2
TthAK1_09580	COG0438	transferase activity, transferring glycosyl groups
TthAK1_09590	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthAK1_09630	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAK1_09630	COG1024	Enoyl-CoA hydratase
TthAK1_09640	COG0183	Belongs to the thiolase family
TthAK1_09650	COG1960	acyl-CoA dehydrogenase activity
TthAK1_09660	COG0215	cysteine-tRNA ligase activity
TthAK1_09670	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthAK1_09730	COG1196	nuclear chromosome segregation
TthAK1_09760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthAK1_09770	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAK1_09770	COG3153	acetyltransferase
TthAK1_09780	COG1268	BioY protein
TthAK1_09800	COG0126	phosphoglycerate kinase activity
TthAK1_09810	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthAK1_09820	COG0824	Thioesterase
TthAK1_09840	COG0557	exoribonuclease II activity
TthAK1_09850	COG1355	regulation of microtubule-based process
TthAK1_09860	COG0617	tRNA 3'-terminal CCA addition
TthAK1_09860	COG1353	crispr-associated protein
TthAK1_09870	COG0237	dephospho-CoA kinase activity
TthAK1_09890	COG0742	ribosomal rna small subunit methyltransferase
TthAK1_09900	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthAK1_09910	COG0138	bifunctional purine biosynthesis protein purh
TthAK1_09920	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthAK1_09940	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthAK1_10070	COG0149	triose-phosphate isomerase activity
TthAK1_10080	COG3239	Fatty acid desaturase
TthAK1_10110	COG1490	D-aminoacyl-tRNA deacylase activity
TthAK1_10120	COG1307	EDD domain protein, DegV family
TthAK1_10130	COG1307	EDD domain protein, DegV family
TthAK1_10140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthAK1_10150	COG1510	regulation of RNA biosynthetic process
TthAK1_10190	COG1136	(ABC) transporter
TthAK1_10220	COG3769	mannosylglycerate metabolic process
TthAK1_10240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthAK1_10260	COG1012	belongs to the aldehyde dehydrogenase family
TthAK1_10270	COG2368	4-hydroxyphenylacetate
TthAK1_10280	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthAK1_10340	COG2050	protein possibly involved in aromatic compounds catabolism
TthAK1_10350	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthAK1_10370	COG1012	belongs to the aldehyde dehydrogenase family
TthAK1_10370	COG2030	dehydratase
TthAK1_10410	COG3396	Phenylacetate-CoA oxygenase
TthAK1_10430	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthAK1_10450	COG0395	ABC-type sugar transport system, permease component
TthAK1_10490	COG1980	fructose-bisphosphate aldolase activity
TthAK1_10500	COG1733	regulation of RNA biosynthetic process
TthAK1_10510	COG2193	ferroxidase activity
TthAK1_10520	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthAK1_10530	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthAK1_10550	COG1331	Highly conserved protein containing a thioredoxin domain
TthAK1_10560	COG0183	Belongs to the thiolase family
TthAK1_10570	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthAK1_10580	COG0477	Major facilitator Superfamily
TthAK1_10590	COG1846	Transcriptional regulator
TthAK1_10680	COG1012	belongs to the aldehyde dehydrogenase family
TthAK1_10690	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthAK1_10700	COG0210	DNA helicase
TthAK1_10750	COG0745	RESPONSE REGULATOR receiver
TthAK1_10760	COG2205	protein histidine kinase activity
TthAK1_10790	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TthAK1_10800	COG1136	(ABC) transporter
TthAK1_10810	COG0577	efflux transmembrane transporter activity
TthAK1_10810	COG1136	(ABC) transporter
TthAK1_10890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAK1_10940	COG0582	viral genome integration into host DNA
TthAK1_10970	COG2897	thiosulfate sulfurtransferase activity
TthAK1_10980	COG1760	l-serine dehydratase
TthAK1_11000	COG0335	large ribosomal subunit rRNA binding
TthAK1_11010	COG0336	Belongs to the RNA methyltransferase TrmD family
TthAK1_11020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthAK1_11030	COG1837	Belongs to the UPF0109 family
TthAK1_11040	COG0228	four-way junction DNA binding
TthAK1_11070	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAK1_11080	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAK1_11080	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAK1_11090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthAK1_11110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthAK1_11130	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthAK1_11140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthAK1_11150	COG1702	phosphate starvation-inducible protein PhoH
TthAK1_11170	COG4864	UPF0365 protein
TthAK1_11190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthAK1_11230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAK1_11230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthAK1_11240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthAK1_11260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthAK1_11270	COG1397	ADP-ribosylglycohydrolase
TthAK1_11280	COG2239	Acts as a magnesium transporter
TthAK1_11290	COG2304	oxidoreductase activity
TthAK1_11300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAK1_11300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthAK1_11320	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAK1_11320	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthAK1_11330	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthAK1_11340	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthAK1_11350	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthAK1_11360	COG0006	proline dipeptidase activity
TthAK1_11380	COG0739	heme binding
TthAK1_11400	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthAK1_11410	COG0254	rRNA binding
TthAK1_11430	COG2001	Belongs to the MraZ family
TthAK1_11440	COG0275	rRNA processing
TthAK1_11470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthAK1_11490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAK1_11500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthAK1_11510	COG0772	Belongs to the SEDS family
TthAK1_11520	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthAK1_11530	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthAK1_11540	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthAK1_11580	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthAK1_11610	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthAK1_11630	COG0159	tryptophan synthase activity
TthAK1_11640	COG0133	tryptophan synthase activity
TthAK1_11650	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthAK1_11660	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthAK1_11670	COG1744	ABC transporter substrate-binding protein PnrA-like
TthAK1_11680	COG3845	ABC transporter
TthAK1_11780	COG0438	transferase activity, transferring glycosyl groups
TthAK1_11790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthAK1_11810	COG0039	L-malate dehydrogenase activity
TthAK1_11830	COG2819	hydrolase of the alpha beta superfamily
TthAK1_11840	COG0861	Integral membrane protein TerC family
TthAK1_11860	COG0247	lactate metabolic process
TthAK1_11860	COG2181	nitrate reductase activity
TthAK1_11880	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthAK1_11890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthAK1_11900	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthAK1_11920	COG0439	Biotin carboxylase
TthAK1_11930	COG0511	ligase activity, forming carbon-carbon bonds
TthAK1_11940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthAK1_11980	COG0010	Belongs to the arginase family
TthAK1_12010	COG1100	Small GTP-binding protein
TthAK1_12030	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthAK1_12040	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthAK1_12060	COG2814	Major facilitator Superfamily
TthAK1_12070	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthAK1_12080	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAK1_12090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthAK1_12100	COG0589	response to stress
TthAK1_12130	COG3335	DDE superfamily endonuclease
TthAK1_12150	COG0517	IMP dehydrogenase activity
TthAK1_12150	COG0617	tRNA 3'-terminal CCA addition
TthAK1_12150	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAK1_12160	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthAK1_12170	COG0745	RESPONSE REGULATOR receiver
TthAK1_12180	COG5002	protein histidine kinase activity
TthAK1_12190	COG1960	acyl-CoA dehydrogenase activity
TthAK1_12200	COG2086	electron transfer activity
TthAK1_12210	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthAK1_12230	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAK1_12240	COG1573	uracil-dna glycosylase
TthAK1_12250	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthAK1_12250	COG1796	DNA polymerase
TthAK1_12280	COG2309	aminopeptidase activity
TthAK1_12300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAK1_12320	COG1011	Hydrolase
TthAK1_12360	COG2873	o-acetylhomoserine
TthAK1_12370	COG2358	TRAP transporter, solute receptor (TAXI family
TthAK1_12390	COG1126	abc transporter atp-binding protein
TthAK1_12420	COG0134	indole-3-glycerol-phosphate synthase activity
TthAK1_12430	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthAK1_12450	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthAK1_12480	COG0765	amino acid transport
TthAK1_12490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthAK1_12510	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthAK1_12520	COG0569	domain protein
TthAK1_12530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAK1_12540	COG1426	Protein conserved in bacteria
TthAK1_12550	COG2313	pseudouridylate synthase activity
TthAK1_12570	COG3001	Fructosamine kinase
TthAK1_12580	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAK1_12600	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthAK1_12640	COG0012	GTP binding
TthAK1_12650	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthAK1_12670	COG0424	maF-like protein
TthAK1_12700	COG0768	penicillin binding
TthAK1_12710	COG0850	regulation of cytokinetic process
TthAK1_12720	COG2322	membrane
TthAK1_12760	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthAK1_12770	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAK1_12790	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthAK1_12830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthAK1_12850	COG1131	(ABC) transporter
TthAK1_12880	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAK1_12910	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthAK1_12920	COG0440	acetolactate synthase activity
TthAK1_12930	COG0028	Belongs to the TPP enzyme family
TthAK1_12940	COG0492	ferredoxin-NADP+ reductase activity
TthAK1_12950	COG4970	Tfp pilus assembly protein FimT
TthAK1_12960	COG4970	Tfp pilus assembly protein FimT
TthAK1_12970	COG2165	general secretion pathway protein
TthAK1_12980	COG4966	pilus assembly protein PilW
TthAK1_13000	COG2165	general secretion pathway protein
TthAK1_13020	COG4636	protein conserved in cyanobacteria
TthAK1_13060	COG0180	Tryptophanyl-tRNA synthetase
TthAK1_13070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAK1_13080	COG0066	3-isopropylmalate dehydratase activity
TthAK1_13090	COG0473	3-isopropylmalate dehydrogenase activity
TthAK1_13120	COG0300	oxidoreductase activity
TthAK1_13130	COG0129	dihydroxy-acid dehydratase activity
TthAK1_13150	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthAK1_13160	COG1177	transmembrane transport
TthAK1_13170	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthAK1_13180	COG3842	ATPase activity
TthAK1_13190	COG0772	Belongs to the SEDS family
TthAK1_13200	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthAK1_13210	COG2894	cell division
TthAK1_13220	COG1733	regulation of RNA biosynthetic process
TthAK1_13240	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAK1_13240	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthAK1_13260	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAK1_13270	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAK1_13280	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAK1_13290	COG0653	protein targeting
TthAK1_13300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthAK1_13340	COG0393	Putative heavy-metal-binding
TthAK1_13350	COG1111	helicase
TthAK1_13350	COG1205	dead DEAH box helicase
TthAK1_13380	COG0358	DNA primase activity
TthAK1_13410	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthAK1_13420	COG0697	spore germination
TthAK1_13430	COG0612	Peptidase, M16
TthAK1_13440	COG0612	Peptidase, M16
TthAK1_13450	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthAK1_13490	COG3335	DDE superfamily endonuclease
TthAK1_13510	COG3335	DDE superfamily endonuclease
TthAK1_13520	COG1394	ATPase activity, coupled to movement of substances
TthAK1_13530	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthAK1_13540	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthAK1_13550	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAK1_13560	COG1527	subunit (C
TthAK1_13570	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthAK1_13590	COG1269	ATP hydrolysis coupled proton transport
TthAK1_13640	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAK1_13660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthAK1_13690	COG0419	ATPase involved in DNA repair
TthAK1_13700	COG0420	3'-5' exonuclease activity
TthAK1_13740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthAK1_13750	COG2884	Cell division ATP-binding protein ftsE
TthAK1_13760	COG0793	Belongs to the peptidase S41A family
TthAK1_13770	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAK1_13770	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthAK1_13780	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthAK1_13790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthAK1_13810	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAK1_13820	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAK1_13830	COG1129	ABC transporter
TthAK1_13840	COG0746	molybdenum cofactor guanylyltransferase activity
TthAK1_13860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAK1_13900	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthAK1_13910	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthAK1_13920	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthAK1_13940	COG1994	Peptidase M50
TthAK1_13940	COG0517	IMP dehydrogenase activity
TthAK1_13950	COG2358	TRAP transporter, solute receptor (TAXI family
TthAK1_13970	COG2358	TRAP transporter, solute receptor (TAXI family
TthAK1_14000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthAK1_14010	COG0788	formyltetrahydrofolate deformylase activity
TthAK1_14020	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthAK1_14030	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthAK1_14040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthAK1_14080	COG0737	Belongs to the 5'-nucleotidase family
TthAK1_14090	COG0174	glutamine synthetase
TthAK1_14110	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthAK1_14150	COG0747	negative chemotaxis
TthAK1_14160	COG0601	transmembrane transport
TthAK1_14170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAK1_14190	COG0285	dihydrofolate synthase activity
TthAK1_14200	COG1132	(ABC) transporter
TthAK1_14210	COG1132	(ABC) transporter
TthAK1_14220	COG0372	Belongs to the citrate synthase family
TthAK1_14230	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthAK1_14240	COG1482	cell wall glycoprotein biosynthetic process
TthAK1_14260	COG1515	deoxyribonuclease V activity
TthAK1_14280	COG0776	regulation of translation
TthAK1_14310	COG2197	response regulator
TthAK1_14320	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthAK1_14330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthAK1_14340	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthAK1_14350	COG1324	tolerance protein
TthAK1_14360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAK1_14400	COG2205	protein histidine kinase activity
TthAK1_14420	COG3335	DDE superfamily endonuclease
TthAK1_14440	COG3335	DDE superfamily endonuclease
TthAK1_14470	COG0247	lactate metabolic process
TthAK1_14480	COG1139	Iron-sulfur cluster binding protein
TthAK1_14490	COG1556	Lactate utilization protein
TthAK1_14510	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthAK1_14520	COG2815	serine threonine protein kinase
TthAK1_14520	COG0515	serine threonine protein kinase
TthAK1_14540	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthAK1_14560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthAK1_14610	COG0473	3-isopropylmalate dehydrogenase activity
TthAK1_14660	COG1450	Type ii and iii secretion system protein
TthAK1_14670	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthAK1_14680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthAK1_14690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthAK1_14700	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthAK1_14700	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthAK1_14710	COG0736	holo-[acyl-carrier-protein] synthase activity
TthAK1_14740	COG1160	GTP binding
TthAK1_14750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthAK1_14760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthAK1_14760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthAK1_14770	COG2814	Major facilitator Superfamily
TthAK1_14780	COG0083	homoserine kinase activity
TthAK1_14800	COG0268	Binds directly to 16S ribosomal RNA
TthAK1_14820	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthAK1_14830	COG0723	plastoquinol--plastocyanin reductase activity
TthAK1_14850	COG3088	subunit of a heme lyase
TthAK1_14850	COG4235	cytochrome complex assembly
TthAK1_14860	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthAK1_14870	COG1138	Cytochrome C-type biogenesis protein
TthAK1_14880	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthAK1_14890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAK1_14900	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthAK1_14910	COG4133	protoheme IX ABC transporter activity
TthAK1_14920	COG0785	Cytochrome C biogenesis protein
TthAK1_14930	COG3258	Cytochrome c
TthAK1_14950	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAK1_14980	COG3258	Cytochrome c
TthAK1_14990	COG2010	Cytochrome c
TthAK1_15000	COG0737	Belongs to the 5'-nucleotidase family
TthAK1_15010	COG2010	Cytochrome c
TthAK1_15020	COG3258	Cytochrome c
TthAK1_15060	COG2010	Cytochrome c
TthAK1_15070	COG3842	ATPase activity
TthAK1_15130	COG0318	PFAM AMP-dependent synthetase and ligase
TthAK1_15150	COG0318	PFAM AMP-dependent synthetase and ligase
TthAK1_15160	COG3360	Dodecin
TthAK1_15190	COG1024	Enoyl-CoA hydratase
TthAK1_15200	COG0813	purine-nucleoside phosphorylase activity
TthAK1_15210	COG1136	(ABC) transporter
TthAK1_15220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAK1_15230	COG2045	Belongs to the ComB family
TthAK1_15250	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthAK1_15270	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthAK1_15290	COG0107	imidazoleglycerol-phosphate synthase activity
TthAK1_15300	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthAK1_15300	COG0140	phosphoribosyl-ATP diphosphatase activity
TthAK1_15310	COG1494	fructose-1,6-bisphosphatase
TthAK1_15320	COG0686	Belongs to the AlaDH PNT family
TthAK1_15330	COG0427	acetyl-CoA hydrolase
TthAK1_15340	COG0084	hydrolase, TatD family'
TthAK1_15350	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthAK1_15370	COG0017	Asparaginyl-tRNA synthetase
TthAK1_15390	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthAK1_15420	COG2009	succinate dehydrogenase
TthAK1_15440	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthAK1_15500	COG0318	PFAM AMP-dependent synthetase and ligase
TthAK1_15510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthAK1_15520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthAK1_15530	COG0504	CTP synthase activity
TthAK1_15570	COG0070	glutamate synthase
TthAK1_15570	COG0069	glutamate synthase activity
TthAK1_15570	COG0067	glutamate synthase
TthAK1_15620	COG2197	response regulator
TthAK1_15710	COG0840	transmembrane signaling receptor activity
TthAK1_15720	COG0305	Participates in initiation and elongation during chromosome replication
TthAK1_15740	COG0475	glutathione-regulated potassium exporter activity
TthAK1_15750	COG0517	IMP dehydrogenase activity
TthAK1_15750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthAK1_15750	COG0617	tRNA 3'-terminal CCA addition
TthAK1_15780	COG0475	glutathione-regulated potassium exporter activity
TthAK1_15790	COG0490	domain, Protein
TthAK1_15830	COG3118	belongs to the thioredoxin family
TthAK1_15910	COG0542	response to heat
TthAK1_15920	COG0789	Transcriptional regulator
TthAK1_15930	COG0484	heat shock protein binding
TthAK1_15940	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthAK1_15950	COG0443	Heat shock 70 kDa protein
TthAK1_15960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthAK1_15970	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthAK1_15980	COG0616	signal peptide processing
TthAK1_16010	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthAK1_16020	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAK1_16030	COG0714	Associated with various cellular activities
TthAK1_16040	COG0574	Belongs to the PEP-utilizing enzyme family
TthAK1_16040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthAK1_16070	COG5002	protein histidine kinase activity
TthAK1_16070	COG3850	Histidine kinase
TthAK1_16120	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthAK1_16150	COG1011	Hydrolase
TthAK1_16200	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthAK1_16230	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthAK1_16250	COG0047	phosphoribosylformylglycinamidine synthase activity
TthAK1_16270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthAK1_16280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthAK1_16290	COG0116	Belongs to the methyltransferase superfamily
TthAK1_16320	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthAK1_16330	COG0497	DNA recombination
TthAK1_16350	COG0604	alcohol dehydrogenase
TthAK1_16390	COG0585	pseudouridine synthase activity
TthAK1_16440	COG1595	DNA-templated transcription, initiation
TthAK1_16450	COG0557	exoribonuclease II activity
TthAK1_16460	COG0538	isocitrate dehydrogenase activity
TthAK1_16480	COG0582	viral genome integration into host DNA
TthAK1_16560	COG0037	tRNA processing
TthAK1_16560	COG0590	tRNA wobble adenosine to inosine editing
TthAK1_16600	COG2050	protein possibly involved in aromatic compounds catabolism
TthAK1_16620	COG3335	DDE superfamily endonuclease
TthAK1_16650	COG0322	excinuclease ABC activity
TthAK1_16660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAK1_16670	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthAK1_16680	COG1854	S-ribosylhomocysteine lyase activity
TthAK1_16710	COG0519	Catalyzes the synthesis of GMP from XMP
TthAK1_16710	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthAK1_16720	COG4636	protein conserved in cyanobacteria
TthAK1_16730	COG4274	PFAM GYD family protein
TthAK1_16740	COG0346	lactoylglutathione lyase activity
TthAK1_16750	COG0328	RNA-DNA hybrid ribonuclease activity
TthAK1_16760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthAK1_16770	COG2095	MarC family integral membrane protein
TthAK1_16780	COG1438	arginine binding
TthAK1_16790	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthAK1_16800	COG1758	RNA polymerase activity
TthAK1_16810	COG0194	GDP metabolic process
TthAK1_16830	COG3335	DDE superfamily endonuclease
TthAK1_16880	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthAK1_16890	COG2385	sporulation resulting in formation of a cellular spore
TthAK1_16900	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthAK1_16920	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthAK1_17000	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAK1_17010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthAK1_17020	COG1012	belongs to the aldehyde dehydrogenase family
TthAK1_17030	COG0506	proline dehydrogenase activity
TthAK1_17060	COG0156	8-amino-7-oxononanoate synthase activity
TthAK1_17070	COG0827	DNA restriction-modification system
TthAK1_17070	COG0732	type I restriction modification DNA specificity domain
TthAK1_17090	COG0187	DNA topoisomerase II activity
TthAK1_17100	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthAK1_17110	COG0193	aminoacyl-tRNA hydrolase activity
TthAK1_17120	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthAK1_17170	COG2815	serine threonine protein kinase
TthAK1_17170	COG0515	serine threonine protein kinase
TthAK1_17180	COG0631	protein serine/threonine phosphatase activity
TthAK1_17200	COG2814	Major facilitator Superfamily
TthAK1_17210	COG0113	porphobilinogen synthase activity
TthAK1_17220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthAK1_17230	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthAK1_17280	COG1506	peptidase
TthAK1_17280	COG0823	Involved in the tonB-independent uptake of proteins
TthAK1_17280	COG4946	Tricorn protease homolog
TthAK1_17290	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthAK1_17300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthAK1_17340	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthAK1_17350	COG1011	Hydrolase
TthAK1_17400	COG0537	adenosine 5'-monophosphoramidase activity
TthAK1_17410	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthAK1_17420	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthAK1_17430	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthAK1_17440	COG0071	Belongs to the small heat shock protein (HSP20) family
TthAK1_17450	COG2897	thiosulfate sulfurtransferase activity
TthAK1_17460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthAK1_17480	COG1764	response to oxidative stress
TthAK1_17530	COG3842	ATPase activity
TthAK1_17540	COG0101	tRNA pseudouridine synthase activity
TthAK1_17550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthAK1_17560	COG0601	transmembrane transport
TthAK1_17600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthAK1_17630	COG1166	arginine decarboxylase activity
TthAK1_17640	COG3706	GGDEF domain
TthAK1_17650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthAK1_17660	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthAK1_17670	COG1611	Belongs to the LOG family
TthAK1_17680	COG1193	negative regulation of DNA recombination
TthAK1_17700	COG0366	Alpha amylase catalytic
TthAK1_17770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthAK1_17780	COG0142	geranyltranstransferase activity
TthAK1_17810	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthAK1_17870	COG0203	ribosomal protein L17
TthAK1_17880	COG0202	RNA polymerase activity
TthAK1_17890	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthAK1_17900	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthAK1_17910	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthAK1_17920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthAK1_17940	COG0563	adenylate kinase activity
TthAK1_17950	COG0201	protein transport
TthAK1_18000	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthAK1_18010	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthAK1_18020	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthAK1_18070	COG0255	Belongs to the universal ribosomal protein uL29 family
TthAK1_18080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthAK1_18090	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthAK1_18110	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthAK1_18120	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthAK1_18130	COG0089	rRNA binding
TthAK1_18140	COG0088	Forms part of the polypeptide exit tunnel
TthAK1_18160	COG0051	transcription antitermination factor activity, RNA binding
TthAK1_18170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthAK1_18180	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthAK1_18190	COG0049	tRNA binding
TthAK1_18220	COG0442	prolyl-tRNA aminoacylation
TthAK1_18240	COG1115	amino acid carrier protein
TthAK1_18280	COG1489	DNA binding
TthAK1_18310	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthAK1_18350	COG0432	Pfam Uncharacterised protein family UPF0047
TthAK1_18360	COG3253	May function as heme-dependent peroxidase
TthAK1_18370	COG0668	transmembrane transport
TthAK1_18390	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthAK1_18400	COG2217	Heavy metal translocating P-type atpase
TthAK1_18440	COG0745	RESPONSE REGULATOR receiver
TthAK1_18450	COG2205	protein histidine kinase activity
TthAK1_18510	COG2226	methyltransferase
TthAK1_18550	COG2132	Multicopper oxidase
TthAK1_18570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthAK1_18580	COG0822	iron-sulfur transferase activity
TthAK1_18620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthAK1_18640	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthAK1_18650	COG0284	orotidine-5'-phosphate decarboxylase activity
TthAK1_18670	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAK1_18690	COG0416	fatty acid biosynthetic process
TthAK1_18700	COG3118	belongs to the thioredoxin family
TthAK1_18710	COG1185	polyribonucleotide nucleotidyltransferase activity
TthAK1_18720	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthAK1_18740	COG0438	transferase activity, transferring glycosyl groups
TthAK1_18770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthAK1_18780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthAK1_18900	COG0437	4 iron, 4 sulfur cluster binding
TthAK1_18930	COG0825	malonyl-CoA metabolic process
TthAK1_18940	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthAK1_19010	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthAK1_19060	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthAK1_19070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthAK1_19080	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthAK1_19090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthAK1_19110	COG4974	Belongs to the 'phage' integrase family
TthAK1_19270	COG0315	cyclic pyranopterin monophosphate synthase activity
TthAK1_19280	COG2860	membrane
TthAK1_19300	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthAK1_19330	COG0477	Major facilitator Superfamily
TthAK1_19340	COG1694	Mazg nucleotide pyrophosphohydrolase
TthAK1_19350	COG1803	Methylglyoxal synthase
TthAK1_19370	COG0301	tRNA thio-modification
TthAK1_19380	COG0154	amidase activity
TthAK1_19390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthAK1_19440	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthAK1_19450	COG1607	acyl-coa hydrolase
TthAK1_19470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthAK1_19480	COG4149	molybdate abc transporter
TthAK1_19490	COG1840	ABC-type Fe3 transport system, periplasmic component
TthAK1_19520	COG0235	Class ii aldolase
TthAK1_19530	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthAK1_19540	COG0085	RNA polymerase activity
TthAK1_19560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthAK1_19570	COG1077	Cell shape determining protein MreB Mrl
TthAK1_19580	COG1418	mRNA catabolic process
TthAK1_19580	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthAK1_19590	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthAK1_19600	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthAK1_19610	COG1546	Belongs to the CinA family
TthAK1_19610	COG1058	Belongs to the CinA family
TthAK1_19620	COG0354	folic acid binding
TthAK1_19650	COG4948	Mandelate Racemase Muconate Lactonizing
TthAK1_19680	COG1175	transmembrane transport
TthAK1_19700	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthAK1_19720	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthAK1_19740	COG0577	efflux transmembrane transporter activity
TthAK1_19740	COG1136	(ABC) transporter
TthAK1_19750	COG4181	ATPase activity
TthAK1_19760	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthAK1_19790	COG0396	ATPase activity
TthAK1_19800	COG0719	Fe-S assembly protein
TthAK1_19810	COG0719	Fe-S assembly protein
TthAK1_19820	COG2146	nitrite reductase [NAD(P)H] activity
TthAK1_19840	COG0512	Glutamine amidotransferase of anthranilate synthase
TthAK1_19850	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthAK1_19920	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthAK1_19930	COG2226	methyltransferase
TthAK1_19940	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthAK1_19950	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthAK1_19980	COG1774	PSP1 C-terminal conserved region
TthAK1_19990	COG0470	DNA polymerase III
TthAK1_20060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthAK1_20070	COG0302	gtp cyclohydrolase
TthAK1_20110	COG1217	gtp-binding protein TYPA
TthAK1_20130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthAK1_20150	COG0395	ABC-type sugar transport system, permease component
TthAK1_20160	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthAK1_20170	COG1131	(ABC) transporter
TthAK1_20210	COG0556	nucleotide-excision repair
TthAK1_20220	COG0497	DNA recombination
TthAK1_20230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthAK1_20240	COG0445	tRNA wobble uridine modification
TthAK1_20280	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthAK1_20280	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthAK1_20290	COG1543	Belongs to the glycosyl hydrolase 57 family
TthAK1_20300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAK1_20310	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthAK1_20340	COG0189	ligase activity
TthAK1_20370	COG0066	3-isopropylmalate dehydratase activity
TthAK1_20380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthAK1_20410	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthAK1_20420	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthAK1_20430	COG1960	acyl-CoA dehydrogenase activity
TthAK1_20440	COG0163	prenyltransferase activity
TthAK1_20510	COG2096	Adenosyltransferase
TthAK1_20540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthAK1_20550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthAK1_20570	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthAK1_20580	COG0723	plastoquinol--plastocyanin reductase activity
TthAK1_20630	COG1653	transport
TthAK1_20640	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthAK1_20650	COG1960	acyl-CoA dehydrogenase activity
TthAK1_20670	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthAK1_20710	COG0393	Putative heavy-metal-binding
TthAK1_20730	COG3956	TIGRFAM MazG family protein
TthAK1_20750	COG0693	protein deglycase activity
TthAK1_20760	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthAK1_20780	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthAK1_20790	COG1937	Protein conserved in bacteria
TthAK1_20810	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthAK1_20810	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthAK1_20820	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthAK1_20830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthAK1_20870	COG0205	6-phosphofructokinase activity
TthAK1_20880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthAK1_20900	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthAK1_20930	COG2333	competence protein COMEC
TthAK1_20930	COG0658	competence protein
TthAK1_20940	COG1475	DNA binding
TthAK1_20950	COG1192	Involved in chromosome partitioning
TthAK1_20960	COG0357	Ribosomal RNA small subunit methyltransferase G
TthAK1_20980	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthAK1_21010	COG0588	phosphoglycerate mutase activity
TthAK1_21020	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthAK1_21030	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthAK1_21120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthAK1_21120	COG1648	precorrin-2 dehydrogenase activity
TthAK1_21130	COG0778	Nitroreductase
TthAK1_21200	COG1492	cobalamin metabolic process
TthAK1_21210	COG1785	Belongs to the alkaline phosphatase family
TthAK1_21220	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TthAK1_21240	COG3335	DDE superfamily endonuclease
TthAK1_21290	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthAK1_21320	COG1414	Transcriptional regulator
TthAK1_21330	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthAK1_21350	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthAK1_21360	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_21390	COG1028	Short-chain dehydrogenase reductase Sdr
TthAK1_21420	COG1175	transmembrane transport
TthAK1_21450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthAK1_21480	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthAK1_21500	COG1562	ergosterol biosynthetic process
TthAK1_21580	COG1487	ribonuclease activity
TthAK1_21600	COG1304	FMN binding
TthAK1_21680	COG1085	galactose-1-phosphate uridylyltransferase
TthAK1_21690	COG3345	alpha-galactosidase
TthAK1_21740	COG4966	pilus assembly protein PilW
TthAK1_21800	COG1475	DNA binding
TthAK1_21810	COG1192	Involved in chromosome partitioning
TthAK1_21910	COG3256	nitric oxide reductase
TthAK1_21930	COG2010	Cytochrome c
TthAK1_21960	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthAK1_22010	COG4974	Belongs to the 'phage' integrase family
TthAK1_22220	COG0739	heme binding
TthAK1_22240	COG2211	Major facilitator Superfamily
TthAK1_22280	COG2211	Major facilitator Superfamily
TthAK1_22300	COG1797	cobyrinic acid a,c-diamide synthase activity
TthAK1_22310	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TthAK1_22370	COG2084	Dehydrogenase
TthAK1_22390	COG1942	4-Oxalocrotonate Tautomerase
TthAK1_22520	COG3850	Histidine kinase
TthAK1_22520	COG5002	protein histidine kinase activity
TthAK1_22530	COG0745	RESPONSE REGULATOR receiver
TthAK1_22620	COG2801	Transposase and inactivated derivatives
TthAK1_22720	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthAK1_22850	COG2329	Antibiotic biosynthesis monooxygenase
TthAK1_22890	COG1914	H( )-stimulated, divalent metal cation uptake system
TthAK1_22910	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthAK1_22920	COG0642	Histidine kinase
TthAK1_22930	COG0745	RESPONSE REGULATOR receiver
TthAK1_22940	COG0745	RESPONSE REGULATOR receiver
TthAK1_22950	COG0671	phosphoesterase, PA-phosphatase related
TthAK1_23010	COG0730	response to heat
TthAK1_23040	COG0363	glucosamine-6-phosphate deaminase activity
TthAK1_23050	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
TthAK1_23060	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
TthAK1_23150	COG2010	Cytochrome c
TthAK1_23160	COG0745	RESPONSE REGULATOR receiver
TthAK1_23170	COG2205	protein histidine kinase activity
TthAK1_23250	COG4974	Belongs to the 'phage' integrase family
TthAK1_23300	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthAK1_23410	COG3335	DDE superfamily endonuclease
TthAK1_23490	COG1129	ABC transporter
TthAK1_t00340	COG0544	peptidyl-prolyl cis-trans isomerase activity