locus-tag	class	description
TT_C0002	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TT_C0003	ENOG4105C3M	thioredoxin reductase
TT_C0005	ENOG410850P	UPF0102 protein
TT_C0006	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
TT_C0009	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
TT_C0010	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
TT_C0016	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
TT_C0017	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
TT_C0018	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
TT_C0019	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
TT_C0020	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
TT_C0026	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
TT_C0032	ENOG4105E2A	Dehydrogenase
TT_C0038	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
TT_C0039	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
TT_C0040	ENOG4105C34	Pseudouridine synthase
TT_C0043	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
TT_C0044	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
TT_C0045	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
TT_C0046	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
TT_C0047	ENOG4105CHR	reductase
TT_C0048	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
TT_C0049	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TT_C0050	ENOG41067VY	50S ribosomal protein L32
TT_C0057	ENOG4108TVJ	Nitroreductase
TT_C0060	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TT_C0061	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
TT_C0062	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
TT_C0063	ENOG4107Y7Q	pfkb domain protein
TT_C0064	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TT_C0068	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
TT_C0070	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
TT_C0071	ENOG4108IUZ	ABC transporter
TT_C0073	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
TT_C0075	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
TT_C0076	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
TT_C0077	ENOG4107K5T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
TT_C0078	ENOG4105C0Z	ABC transporter
TT_C0079	ENOG4108IQE	Amp-dependent synthetase and ligase
TT_C0080	ENOG4105C32	Amino acid ABC transporter (Permease)
TT_C0081	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TT_C0083	ENOG4108IV0	ABC, transporter
TT_C0084	ENOG4105DIK	(ABC) transporter
TT_C0085	ENOG4105CC5	ABC transporter
TT_C0087	ENOG4107QI6	Cysteine desulfurase
TT_C0088	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
TT_C0089	ENOG4105CAT	Cytidine monophosphate kinase
TT_C0092	ENOG4105CHR	reductase
TT_C0096	ENOG4105CAY	ferredoxin--nadp reductase
TT_C0098	ENOG4107QRA	Extracellular solute-binding protein, family 5
TT_C0100	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TT_C0103	ENOG41080XP	Cbs domain
TT_C0104	ENOG4105DGU	Histone deacetylase
TT_C0105	ENOG4106C07	ThiamineS Protein
TT_C0106	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
TT_C0107	ENOG4105CG3	alpha amylase, catalytic region
TT_C0108	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TT_C0109	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TT_C0110	ENOG4105CE8	Transfers the fatty acyl group on membrane lipoproteins (By similarity)
TT_C0112	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
TT_C0115	ENOG4105D6E	homoserine dehydrogenase
TT_C0122	ENOG4106YGA	NADH dehydrogenase (quinone)
TT_C0123	ENOG4105CSA	Coproporphyrinogen iii oxidase
TT_C0127	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
TT_C0129	ENOG4105CQB	FAD linked oxidase domain protein
TT_C0130	ENOG4107R9S	Malate synthase
TT_C0131	ENOG4107HP6	Transcriptional regulator
TT_C0132	ENOG4105KNI	merR family transcriptional Regulator
TT_C0133	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TT_C0134	ENOG4108Z7R	Chaperone CsaA
TT_C0135	ENOG4105DZS	Phenylacetate-CoA ligase
TT_C0137	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
TT_C0138	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
TT_C0142	ENOG4107TS3	membrane protein, TerC
TT_C0143	ENOG4105VG1	fes assembly suf system protein
TT_C0144	ENOG4107R1I	NAD-dependent malic enzyme
TT_C0148	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
TT_C0149	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
TT_C0150	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT_C0151	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT_C0152	ENOG4105K8Z	Phage shock protein
TT_C0154	ENOG4105QA4	4Fe-4S Ferredoxin, iron-sulfur binding domain protein
TT_C0155	ENOG4107QY8	reductase
TT_C0157	ENOG4105WH1	Two component transcriptional regulator luxr family
TT_C0159	ENOG4105DTN	riboflavin biosynthesis protein ribF
TT_C0160	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
TT_C0164	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
TT_C0165	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
TT_C0166	ENOG4105CFH	Aspartokinase
TT_C0167	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
TT_C0168	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TT_C0169	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
TT_C0170	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
TT_C0171	ENOG4108JVH	Protein of unknown function DUF43
TT_C0172	ENOG4105CTP	PilT protein domain protein
TT_C0173	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
TT_C0175	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
TT_C0181	ENOG4105CX6	glutaminyL-tRNA synthetase
TT_C0183	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
TT_C0184	ENOG410868C	50s ribosomal protein l35
TT_C0185	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
TT_C0187	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TT_C0188	ENOG41080X4	futalosine nucleosidase
TT_C0189	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
TT_C0190	ENOG4105C9Q	fumarate hydratase class II
TT_C0194	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
TT_C0195	ENOG4105DFA	alanine racemase domain protein
TT_C0198	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
TT_C0199	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
TT_C0201	ENOG4105CPQ	Dehydrogenase
TT_C0204	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
TT_C0205	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TT_C0206	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
TT_C0210	ENOG4105DBI	uridine monophosphokinase
TT_C0211	ENOG4108IJ9	(ABC) transporter
TT_C0214	ENOG4108UIC	UPF0340 protein
TT_C0216	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TT_C0218	ENOG4105C0Z	ABC transporter
TT_C0219	ENOG4108IV0	ABC, transporter
TT_C0221	ENOG4105CP9	extracellular ligand-binding receptor
TT_C0225	ENOG4105CH5	extracellular solute-binding protein, family 7
TT_C0226	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
TT_C0227	ENOG4105DSE	periplasmic solute binding protein
TT_C0230	ENOG4105C1Q	protoporphyrinogen oxidase
TT_C0231	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
TT_C0232	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
TT_C0233	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
TT_C0236	ENOG4105CEY	Amp-dependent synthetase and ligase
TT_C0237	ENOG4105DXM	phenylacetic acid degradation protein
TT_C0238	ENOG4105C1G	acyl-Coa dehydrogenase
TT_C0241	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
TT_C0242	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
TT_C0244	ENOG41066UU	tRNA (Adenine-N1-)-methyltransferase
TT_C0246	ENOG4105X0R	protein from nitrogen regulatory protein P-II
TT_C0247	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
TT_C0249	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
TT_C0250	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
TT_C0251	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
TT_C0252	ENOG4105DAP	Nicotinate phosphoribosyltransferase
TT_C0253	ENOG4105C3R	Methionine synthase
TT_C0255	ENOG4105CRQ	synthase (Component I)
TT_C0257	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
TT_C0259	ENOG4105D48	metallophosphoesterase
TT_C0260	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
TT_C0261	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
TT_C0264	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
TT_C0265	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
TT_C0279	ENOG4105K64	Glycosyl transferase, family 2
TT_C0285	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
TT_C0286	ENOG4105J5G	Transferase hexapeptide repeat containing protein
TT_C0287	ENOG4107R5Z	Oxidoreductase domain protein
TT_C0288	ENOG4107QQG	Dehydrogenase
TT_C0295	ENOG4105D1F	ATP-binding protein
TT_C0297	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
TT_C0304	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TT_C0307	ENOG4107RIQ	Sulfate adenylate transferase
TT_C0308	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TT_C0309	ENOG4107TSN	permease
TT_C0310	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
TT_C0311	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TT_C0312	ENOG4105EXQ	uroporphyrinogen iii synthase hem4
TT_C0313	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
TT_C0315	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
TT_C0316	ENOG4108G2S	Thiamine biosynthesis protein thiS
TT_C0317	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
TT_C0319	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
TT_C0320	ENOG41079KZ	Major Facilitator Superfamily
TT_C0321	ENOG4105DWF	phosphomethylpyrimidine kinase
TT_C0329	ENOG4105E2R	ROK family
TT_C0330	ENOG4105CHU	acetyl-coa acetyltransferase
TT_C0334	ENOG4108IV0	ABC, transporter
TT_C0335	ENOG4105C0Z	ABC transporter
TT_C0337	ENOG4105C32	Amino acid ABC transporter (Permease)
TT_C0339	ENOG4108Z7G	MaoC domain protein dehydratase
TT_C0341	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
TT_C0342	ENOG4105CEY	Amp-dependent synthetase and ligase
TT_C0343	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
TT_C0345	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
TT_C0347	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
TT_C0349	ENOG4105CHV	Transcription elongation factor NusA
TT_C0350	ENOG410836C	Required for maturation of 30S ribosomal subunits (By similarity)
TT_C0351	ENOG4105DR5	peptidase
TT_C0352	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
TT_C0353	ENOG4107YCR	Transcriptional regulator, ARSR family
TT_C0354	ENOG4105C59	p-type ATPase
TT_C0355	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
TT_C0356	ENOG4105C5S	asparaginyl-tRNA synthetase
TT_C0358	ENOG4107ZY0	Phenazine biosynthesis-like protein
TT_C0359	ENOG4105C9M	aspartyl-trna synthetase
TT_C0360	ENOG4105CUT	histidyl-tRNA synthetase
TT_C0364	ENOG4105E0C	molybdate abc transporter
TT_C0365	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
TT_C0366	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
TT_C0370	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
TT_C0371	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TT_C0373	ENOG4108KGH	TRANSCRIPTIONal
TT_C0374	ENOG4107QM5	aconitate hydratase
TT_C0377	ENOG4105BZS	acriflavin resistance protein
TT_C0383	ENOG4105KG3	cytidine deaminase
TT_C0385	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TT_C0389	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
TT_C0391	ENOG4105EHG	Permease protein
TT_C0392	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
TT_C0394	ENOG4105CHR	reductase
TT_C0396	ENOG4107S1E	Beta-lactamase
TT_C0402	ENOG4105BZU	Histidine kinase
TT_C0403	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
TT_C0404	ENOG4105F6J	Alpha beta hydrolase fold
TT_C0407	ENOG4105DWV	Homoserine O-trans-acetylase
TT_C0408	ENOG4108IQK	o-acetylhomoserine
TT_C0411	ENOG4107WTH	Galactitol-1-phosphate dehydrogenase
TT_C0414	ENOG4105CH5	extracellular solute-binding protein, family 7
TT_C0416	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TT_C0418	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TT_C0419	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
TT_C0420	ENOG4108IY8	ABC, transporter
TT_C0421	ENOG4105D2X	ABC transporter substrate-binding protein
TT_C0422	ENOG4105BZU	Histidine kinase
TT_C0424	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
TT_C0426	ENOG4105CD3	dihydroorotase
TT_C0427	ENOG4105CXT	aspartate transcarbamylase
TT_C0428	ENOG4108UK1	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)
TT_C0431	ENOG4105C5I	Dehydrogenase
TT_C0433	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
TT_C0435	ENOG4105C1G	acyl-Coa dehydrogenase
TT_C0436	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
TT_C0438	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
TT_C0439	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TT_C0443	ENOG4105CQB	FAD linked oxidase domain protein
TT_C0446	ENOG4105BZU	Histidine kinase
TT_C0447	ENOG4105EVN	Prephenate dehydrogenase
TT_C0448	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
TT_C0449	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
TT_C0450	ENOG4108YYC	ycei family
TT_C0451	ENOG4108XHF	Pfam:DUF178
TT_C0452	ENOG4105DVY	radical SAM domain protein
TT_C0455	ENOG4105ETE	Transcriptional regulator (LacI family
TT_C0456	ENOG41071YG	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TT_C0457	ENOG4105ERH	Fumarylacetoacetate hydrolase
TT_C0459	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
TT_C0460	ENOG4107QNG	Phosphoribosylglycinamide synthetase
TT_C0461	ENOG4108IRC	dna polymerase iii
TT_C0463	ENOG4105BZU	Histidine kinase
TT_C0467	ENOG4107QN1	sodium solute
TT_C0469	ENOG4105CDY	transcriptional regulatory protein
TT_C0470	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
TT_C0471	ENOG4107ZQN	disulfide bond
TT_C0472	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
TT_C0473	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TT_C0474	ENOG4105CNU	cell division protein FtsK
TT_C0477	ENOG4105W87	Cbs domain
TT_C0481	ENOG4108Z4T	Peptidase M50
TT_C0482	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
TT_C0484	ENOG41082J7	Rhodanese domain protein
TT_C0487	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
TT_C0489	ENOG4105ED1	spovr family
TT_C0490	ENOG4106AKX	UPF0229 protein
TT_C0491	ENOG4105CYN	Serine protein kinase
TT_C0498	ENOG4105MCT	stage V sporulation protein S
TT_C0499	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TT_C0500	ENOG4105II7	pyrroline-5-carboxylate reductase
TT_C0502	ENOG4105C3Q	Glycosyl transferase, family 2
TT_C0503	ENOG4105DZP	Membrane-associated zinc metalloprotease
TT_C0504	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
TT_C0505	ENOG4105KNE	Phosphatidate cytidylyltransferase
TT_C0506	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
TT_C0507	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
TT_C0508	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
TT_C0509	ENOG4105CE9	30S ribosomal protein S2
TT_C0510	ENOG4108JPW	Aminotransferase
TT_C0511	ENOG4108YZ4	nudix hydrolase
TT_C0514	ENOG4105KHN	chorismate mutase
TT_C0517	ENOG4107Y3Y	amidohydrolase
TT_C0519	ENOG4105DTQ	mandelate racemase muconate lactonizing
TT_C0520	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
TT_C0522	ENOG4108UQV	Membrane
TT_C0523	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
TT_C0526	ENOG4108SHN	Glycosyl transferase, family 2
TT_C0527	ENOG4107V8I	Glycosyl transferases group 1
TT_C0530	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
TT_C0535	ENOG4105CHU	acetyl-coa acetyltransferase
TT_C0536	ENOG4105C1G	acyl-Coa dehydrogenase
TT_C0537	ENOG4105C8N	cysteinyl-tRNA synthetase
TT_C0538	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
TT_C0539	ENOG41068KF	Universal stress protein
TT_C0543	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
TT_C0545	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
TT_C0546	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
TT_C0547	ENOG4105DGM	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
TT_C0548	ENOG4107ZYJ	bioY protein
TT_C0549	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
TT_C0550	ENOG4105BZA	Phosphoglycerate kinase
TT_C0553	ENOG4105C8Y	Acetylornithine aminotransferase
TT_C0554	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
TT_C0555	ENOG41081CK	Memo-like protein
TT_C0556	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
TT_C0557	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
TT_C0559	ENOG4106H78	methyltransferase
TT_C0560	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
TT_C0561	ENOG4105DC1	bifunctional purine biosynthesis protein purh
TT_C0562	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
TT_C0564	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
TT_C0570	ENOG4105CHM	Aminotransferase
TT_C0573	ENOG4105CIG	ABC transporter
TT_C0581	ENOG4105CP7	Triose-phosphate isomerase
TT_C0582	ENOG4105ECK	Fatty Acid Desaturase
TT_C0583	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
TT_C0584	ENOG4105EPR	degv family
TT_C0585	ENOG4105EPR	degv family
TT_C0587	ENOG410600Z	Regulatory protein MarR
TT_C0589	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
TT_C0591	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
TT_C0593	ENOG4105C26	Dehydrogenase
TT_C0594	ENOG4105EFA	4-hydroxyphenylacetate
TT_C0595	ENOG4105MXW	flavin reductase domain protein, FMN-binding
TT_C0598	ENOG4105C32	Amino acid ABC transporter (Permease)
TT_C0599	ENOG4105C0Z	ABC transporter
TT_C0600	ENOG4108IV0	ABC, transporter
TT_C0601	ENOG4107YAU	phenylacetic acid degradation protein
TT_C0602	ENOG4105DZS	Phenylacetate-CoA ligase
TT_C0604	ENOG4105DXM	phenylacetic acid degradation protein
TT_C0608	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
TT_C0610	ENOG4108IYS	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
TT_C0616	ENOG4107NFR	Fructose-1,6-bisphosphatase
TT_C0618	ENOG4108UQY	Iron-storage protein
TT_C0619	ENOG4108IYU	L-aspartate oxidase
TT_C0620	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
TT_C0621	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
TT_C0622	ENOG4105C7Z	Conserved Protein
TT_C0623	ENOG4105CHU	acetyl-coa acetyltransferase
TT_C0624	ENOG4105P4J	Allophanate hydrolase, subunit 1
TT_C0625	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
TT_C0627	ENOG4105BZU	Histidine kinase
TT_C0628	ENOG4105BZU	Histidine kinase
TT_C0629	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TT_C0633	ENOG4105ETX	regulatoR
TT_C0634	ENOG4105C26	Dehydrogenase
TT_C0636	ENOG4105C9X	ppx gppa phosphatase
TT_C0637	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
TT_C0643	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
TT_C0644	ENOG4106F60	Histidine kinase
TT_C0648	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TT_C0649	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TT_C0665	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
TT_C0666	ENOG4105KHC	sulfurtransferase
TT_C0667	ENOG4105EJQ	L-serine dehydratase
TT_C0668	ENOG4105WH1	Two component transcriptional regulator luxr family
TT_C0669	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
TT_C0670	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
TT_C0671	ENOG4106GF2	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
TT_C0672	ENOG4105VB6	UPF0109 protein
TT_C0673	ENOG4105K5M	30s ribosomal protein S16
TT_C0674	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TT_C0679	ENOG4105CRK	lysyL-tRNA synthetase
TT_C0680	ENOG4105RTX	GreA GreB family elongation factor
TT_C0682	ENOG41080IJ	Diacylglycerol kinase
TT_C0683	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
TT_C0684	ENOG4105C9A	Phoh family
TT_C0686	ENOG4105DI5	UPF0365 protein
TT_C0688	ENOG4105E2X	shikimate dehydrogenase
TT_C0690	ENOG4105C2M	dna polymerase I
TT_C0691	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
TT_C0693	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
TT_C0694	ENOG41065RQ	ADP-ribosylation crystallin J1
TT_C0695	ENOG4105CJW	magnesium transporter
TT_C0697	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
TT_C0699	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
TT_C0700	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
TT_C0701	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
TT_C0702	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
TT_C0703	ENOG4105DC7	peptidase M24
TT_C0705	ENOG4105FRN	stage II sporulation protein
TT_C0707	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
TT_C0708	ENOG41082DI	50s ribosomal protein l31
TT_C0710	ENOG4108V6E	Cell division protein mraZ
TT_C0711	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
TT_C0713	ENOG4105CJN	penicillin-binding protein
TT_C0714	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
TT_C0716	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
TT_C0717	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
TT_C0718	ENOG4105CNI	cell division protein FtsW
TT_C0719	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
TT_C0720	ENOG4105DFU	Cell wall formation (By similarity)
TT_C0721	ENOG4107QWW	Cell wall formation (By similarity)
TT_C0723	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
TT_C0725	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
TT_C0727	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
TT_C0729	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
TT_C0730	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
TT_C0731	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
TT_C0732	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
TT_C0733	ENOG4105DIH	basic membrane
TT_C0734	ENOG4108JQ9	ABC transporter
TT_C0745	ENOG4105CPK	Glycosyl transferase (Group 1
TT_C0746	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
TT_C0748	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
TT_C0749	ENOG4108SA1	esterase
TT_C0750	ENOG4107TS3	membrane protein, TerC
TT_C0752	ENOG4105DF6	Fe-S oxidoreductase
TT_C0755	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
TT_C0756	ENOG41082MB	Involved in the transcription termination process (By similarity)
TT_C0758	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
TT_C0759	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
TT_C0760	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
TT_C0764	ENOG4105CYW	agmatinase
TT_C0767	ENOG4105CXV	gliding motility protein
TT_C0769	ENOG4105NAA	Cytochrome C oxidase, subunit II
TT_C0770	ENOG4107RQ2	Cytochrome c oxidase, subunit I
TT_C0772	ENOG4107RGD	Major Facilitator superfamily
TT_C0773	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
TT_C0774	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TT_C0775	ENOG4105CN5	Metallo-Beta-Lactamase
TT_C0777	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
TT_C0778	ENOG4105BZU	Histidine kinase
TT_C0779	ENOG4105C1G	acyl-Coa dehydrogenase
TT_C0780	ENOG4105BZJ	Electron transfer flavoprotein
TT_C0781	ENOG4105C10	Electron transfer flavoprotein
TT_C0783	ENOG4108HNZ	carboxyl transferase
TT_C0784	ENOG4105E50	uracil-dna glycosylase
TT_C0785	ENOG4105DCG	PHP domain protein
TT_C0788	ENOG4105C88	aminopeptidase
TT_C0792	ENOG4108FXY	Cys/Met metabolism PLP-dependent enzyme
TT_C0795	ENOG4105CDA	abc transporter atp-binding protein
TT_C0797	ENOG4105D78	K07001 NTE family protein
TT_C0798	ENOG4105VT3	DNA binding domain protein, excisionase family
TT_C0800	ENOG4105DK0	Indole-3-glycerol phosphate synthase
TT_C0801	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
TT_C0803	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
TT_C0805	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
TT_C0806	ENOG4105E5Q	amino acid AbC transporter
TT_C0807	ENOG4105EAB	amino acid AbC transporter
TT_C0809	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
TT_C0810	ENOG4105C1A	potassium transporter peripheral membrane
TT_C0811	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
TT_C0812	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
TT_C0813	ENOG4105D53	Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity)
TT_C0816	ENOG4105KJF	protein tyrosine phosphatase
TT_C0818	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
TT_C0822	ENOG4105C3G	gtp-binding protein
TT_C0823	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
TT_C0825	ENOG4108Z03	MAF-like protein
TT_C0828	ENOG4105CJN	penicillin-binding protein
TT_C0831	ENOG4108SJC	Membrane
TT_C0835	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
TT_C0836	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TT_C0838	ENOG4105DBV	ornithine carbamoyltransferase
TT_C0841	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
TT_C0843	ENOG4105CJ1	ABC, transporter
TT_C0847	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TT_C0849	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
TT_C0850	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
TT_C0852	ENOG4105C7K	acetolactate synthase
TT_C0853	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
TT_C0858	ENOG4108VAU	general secretion pathway protein G
TT_C0864	ENOG4105C31	Tryptophanyl-tRNA synthetase
TT_C0865	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TT_C0866	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TT_C0867	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TT_C0871	ENOG4105C01	Dihydroxy-acid dehydratase
TT_C0873	ENOG4107RUE	extracellular solute-binding protein family 1
TT_C0874	ENOG4105D38	putrescine abc transporter
TT_C0875	ENOG4105F38	ABC transporter, permease
TT_C0876	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TT_C0877	ENOG4105CNI	cell division protein FtsW
TT_C0878	ENOG4108CHF	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
TT_C0879	ENOG4107QMS	site-determining protein
TT_C0884	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TT_C0885	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TT_C0886	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TT_C0887	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
TT_C0888	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
TT_C0892	ENOG4105K8R	UPF0145 protein
TT_C0893	ENOG4108I5C	dEAD DEAH box helicase
TT_C0896	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
TT_C0897	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
TT_C0898	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
TT_C0899	ENOG4107Y9U	Membrane
TT_C0900	ENOG4105C1V	Peptidase, M16
TT_C0905	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TT_C0906	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
TT_C0907	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
TT_C0908	ENOG410704R	Produces ATP from ADP in the presence of a proton gradient across the membrane
TT_C0909	ENOG41089ID	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
TT_C0912	ENOG4105EBX	v-type atpase
TT_C0917	ENOG4105E8R	UPF0173 metal-dependent hydrolase
TT_C0918	ENOG4108V5V	Serine Threonine protein kinase
TT_C0919	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
TT_C0920	ENOG4105CJR	Integral membrane protein (MviN
TT_C0922	ENOG4105EYH	Exonuclease
TT_C0927	ENOG4105MS2	ribosomal subunit Interface protein
TT_C0928	ENOG4105CAK	Cell division ATP-binding protein ftsE
TT_C0929	ENOG4105CN1	protease
TT_C0931	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
TT_C0932	ENOG4105E66	phosphoriboisomerase A
TT_C0933	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TT_C0938	ENOG4105C2J	ABC transporter
TT_C0939	ENOG41080QG	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
TT_C0942	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TT_C0946	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
TT_C0947	ENOG4105ESV	Glycosyl transferase, family 4
TT_C0948	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
TT_C0956	ENOG4105C0H	protease
TT_C0957	ENOG4105CIY	formyltetrahydrofolate deformylase
TT_C0958	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
TT_C0959	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
TT_C0960	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
TT_C0962	ENOG41067HZ	cytochrome C, class I
TT_C0964	ENOG4105CGH	5'-nucleotidase
TT_C0965	ENOG4105C5F	glutamine synthetase
TT_C0967	ENOG4105C32	Amino acid ABC transporter (Permease)
TT_C0968	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
TT_C0969	ENOG4105C0Z	ABC transporter
TT_C0970	ENOG4108IV0	ABC, transporter
TT_C0971	ENOG4105DEF	Extracellular solute-binding protein, family 5
TT_C0972	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
TT_C0973	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TT_C0975	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TT_C0976	ENOG4105BZ1	(ABC) transporter
TT_C0977	ENOG4105BZ1	(ABC) transporter
TT_C0978	ENOG4105BZN	citrate synthase
TT_C0979	ENOG4105D06	uba thif-type nad fad binding protein
TT_C0980	ENOG4105DG6	mannose-6-phosphate isomerase
TT_C0982	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
TT_C0984	ENOG4105K70	DNA-binding protein
TT_C0987	ENOG4105WH1	Two component transcriptional regulator luxr family
TT_C0988	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
TT_C0989	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
TT_C0990	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TT_C0991	ENOG4105VF7	tolerance protein
TT_C0994	ENOG4108W63	CRP FNR family transcriptional regulator
TT_C0998	ENOG4105BZU	Histidine kinase
TT_C1000	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
TT_C1001	ENOG4107QR9	Iron-sulfur cluster binding protein
TT_C1002	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
TT_C1003	ENOG4105C3F	Signal peptidase i
TT_C1004	ENOG4105D78	K07001 NTE family protein
TT_C1005	ENOG4105D9P	serine threonine protein kinase
TT_C1006	ENOG4108KNB	n-acetylmuramoyl-l-alanine amidase
TT_C1008	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
TT_C1010	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TT_C1012	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TT_C1018	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
TT_C1019	ENOG4107ZC0	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
TT_C1020	ENOG4105D49	3-dehydroquinate synthase
TT_C1021	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
TT_C1022	ENOG41084ZW	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
TT_C1025	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
TT_C1026	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
TT_C1027	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
TT_C1028	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
TT_C1031	ENOG4108AH5	Binds directly to 16S ribosomal RNA (By similarity)
TT_C1033	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
TT_C1036	ENOG4105KWW	Biogenesis protein
TT_C1037	ENOG4107QX9	Thiol disulfide interChange protein
TT_C1038	ENOG4105DA4	cytochrome c-type biogenesis protein
TT_C1039	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
TT_C1041	ENOG41060IM	Heme exporter protein
TT_C1042	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
TT_C1043	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
TT_C1044	ENOG4107QIV	Cytochrome c biogenesis protein
TT_C1045	ENOG4105NQN	cytochrome C
TT_C1047	ENOG4107S7U	Sulfide dehydrogenase
TT_C1050	ENOG4105QN4	diheme cytochrome
TT_C1051	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
TT_C1052	ENOG4105CGH	5'-nucleotidase
TT_C1053	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
TT_C1054	ENOG4105QN4	diheme cytochrome
TT_C1058	ENOG41067HZ	cytochrome C, class I
TT_C1059	ENOG4108UCS	ABC, transporter
TT_C1063	ENOG4107QKV	phosphomannomutase
TT_C1065	ENOG4105CEY	Amp-dependent synthetase and ligase
TT_C1066	ENOG4105WKW	Pfam:DUF1458
TT_C1069	ENOG4105E39	Enoyl-CoA hydratase
TT_C1070	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
TT_C1071	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
TT_C1072	ENOG4105IJJ	transcriptional regulator, crp fnr family
TT_C1073	ENOG4108N5B	2-phosphosulfolactate phosphatase
TT_C1075	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
TT_C1077	ENOG4108JIF	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
TT_C1079	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
TT_C1080	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
TT_C1081	ENOG4105CBT	Fructose-1,6-bisphosphatase
TT_C1082	ENOG4105DCF	alanine dehydrogenase
TT_C1083	ENOG4105CYC	Transferase
TT_C1084	ENOG4105F8V	Hydrolase, tatD family
TT_C1085	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
TT_C1087	ENOG4105C5S	asparaginyl-tRNA synthetase
TT_C1089	ENOG4105E33	succinate dehydrogenase
TT_C1093	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
TT_C1095	ENOG4105CIG	ABC transporter
TT_C1099	ENOG4105CEY	Amp-dependent synthetase and ligase
TT_C1100	ENOG4108UJD	30S ribosomal protein S9
TT_C1101	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
TT_C1102	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
TT_C1104	ENOG4105CBC	glutamate synthase
TT_C1105	ENOG4106YBV	Methyl-accepting chemotaxis
TT_C1106	ENOG4105CDU	Replicative dna helicase
TT_C1109	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
TT_C1112	ENOG4107S91	Sodium hydrogen exchanger
TT_C1113	ENOG4105NCW	Trka-c domain protein
TT_C1115	ENOG4108ZVP	Domain of unknown function (DUF1931)
TT_C1117	ENOG4105K63	Thioredoxin
TT_C1123	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
TT_C1124	ENOG4108FYC	transcriptional regulator MERR family
TT_C1125	ENOG4105DVC	DnaJ domain protein
TT_C1126	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TT_C1127	ENOG4105CFG	Acts as a chaperone (By similarity)
TT_C1128	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
TT_C1129	ENOG4105DR4	Methyltransferase
TT_C1130	ENOG4105D07	Signal peptide peptidase, SppA
TT_C1133	ENOG4108UKM	mov34 mpn pad-1 family protein
TT_C1134	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TT_C1135	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
TT_C1136	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
TT_C1137	ENOG4108UT2	hemolysin iii
TT_C1139	ENOG41062D9	Histidine kinase
TT_C1142	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
TT_C1144	ENOG4108Z8I	decarboxylase
TT_C1149	ENOG4105C83	adenylosuccinate lyase
TT_C1151	ENOG4105C8V	SAICAR synthetase
TT_C1153	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
TT_C1155	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
TT_C1156	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
TT_C1157	ENOG4108T9W	RNA methylase
TT_C1160	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
TT_C1161	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
TT_C1162	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
TT_C1163	ENOG4105CIS	alcohol dehydrogenase
TT_C1167	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
TT_C1172	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
TT_C1173	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
TT_C1176	ENOG4108FWV	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
TT_C1180	ENOG4105KA0	thioesterase Superfamily protein
TT_C1182	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
TT_C1184	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TT_C1185	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
TT_C1186	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
TT_C1187	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
TT_C1189	ENOG41067KJ	GYD family
TT_C1191	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TT_C1192	ENOG4107QX3	carboxylase
TT_C1193	ENOG41081FY	multiple antibiotic resistance (MarC)-related
TT_C1194	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
TT_C1195	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
TT_C1196	ENOG41079SJ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
TT_C1197	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
TT_C1199	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
TT_C1200	ENOG4105JFG	SpoIID LytB domain protein
TT_C1201	ENOG41074B2	UPF0747 protein
TT_C1203	ENOG4105E63	Pfam:DUF178
TT_C1211	ENOG4105D82	Glutamate dehydrogenase
TT_C1212	ENOG4105D82	Glutamate dehydrogenase
TT_C1213	ENOG4105C26	Dehydrogenase
TT_C1214	ENOG41062BK	proline dehydrogenase
TT_C1219	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
TT_C1220	ENOG4105XEZ	This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the
TT_C1222	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
TT_C1223	ENOG4105CPF	Cell wall formation (By similarity)
TT_C1224	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
TT_C1225	ENOG4107UH2	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
TT_C1228	ENOG4105BZU	Histidine kinase
TT_C1229	ENOG4105ETX	regulatoR
TT_C1230	ENOG4105D9P	serine threonine protein kinase
TT_C1231	ENOG4108ZF3	Phosphatase
TT_C1234	ENOG4105D52	delta-aminolevulinic acid dehydratase
TT_C1235	ENOG41080DW	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
TT_C1236	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
TT_C1241	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
TT_C1242	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
TT_C1243	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
TT_C1247	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
TT_C1248	ENOG4105EJU	HAD-superfamily hydrolase subfamily IA variant 3
TT_C1253	ENOG4107YU2	histidine triad (hIT) protein
TT_C1254	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
TT_C1255	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
TT_C1256	ENOG4105C87	Aminotransferase class I and II
TT_C1257	ENOG4105VN1	Heat shock protein
TT_C1258	ENOG4105KHC	sulfurtransferase
TT_C1259	ENOG4105C5X	domain protein
TT_C1261	ENOG4108Z9K	Osmotically inducible protein
TT_C1264	ENOG4107QKW	extracellular solute-binding protein family 1
TT_C1266	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
TT_C1267	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
TT_C1268	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
TT_C1271	ENOG4107RNA	Nickel ABC transporter, periplasmic nickel-binding protein
TT_C1273	ENOG4105DC7	peptidase M24
TT_C1274	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
TT_C1277	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
TT_C1278	ENOG4105BZU	Histidine kinase
TT_C1279	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
TT_C1280	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
TT_C1281	ENOG4108URH	decarboxylase
TT_C1282	ENOG4105C98	muts2 protein
TT_C1283	ENOG4107R28	alpha amylase, catalytic region
TT_C1286	ENOG4105EG2	ABC transporter, permease
TT_C1287	ENOG4105D56	permease protein
TT_C1290	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
TT_C1291	ENOG4105EAH	synthase
TT_C1299	ENOG4108ZT0	50S ribosomal protein l17
TT_C1300	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TT_C1301	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
TT_C1302	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
TT_C1303	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TT_C1304	ENOG41067V7	50S ribosomal protein L36
TT_C1305	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
TT_C1307	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
TT_C1308	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
TT_C1309	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
TT_C1310	ENOG410856V	50S ribosomal protein L30
TT_C1311	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
TT_C1312	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
TT_C1313	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
TT_C1314	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
TT_C1315	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
TT_C1316	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TT_C1317	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
TT_C1318	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
TT_C1319	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
TT_C1320	ENOG4108CHD	50s ribosomal protein l29
TT_C1321	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
TT_C1322	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
TT_C1323	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
TT_C1324	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
TT_C1325	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TT_C1326	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
TT_C1327	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
TT_C1328	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
TT_C1329	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
TT_C1330	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TT_C1331	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
TT_C1332	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
TT_C1333	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
TT_C1343	ENOG4105PW4	Sugar fermentation stimulation protein homolog
TT_C1351	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
TT_C1352	ENOG4107T9V	chlorite dismutase
TT_C1353	ENOG4105D8X	mechanosensitive ion channel
TT_C1355	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
TT_C1356	ENOG4105C59	p-type ATPase
TT_C1360	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TT_C1361	ENOG4105EB3	Histidine kinase
TT_C1366	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TT_C1370	ENOG4107STQ	Multicopper oxidase
TT_C1373	ENOG4105C9B	Cysteine desulfurase
TT_C1374	ENOG4108UNV	SUF system FeS assembly protein, NifU family
TT_C1376	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
TT_C1378	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
TT_C1380	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
TT_C1381	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
TT_C1382	ENOG4107YEI	lmbE family
TT_C1384	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
TT_C1385	ENOG4105K63	Thioredoxin
TT_C1386	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
TT_C1387	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TT_C1389	ENOG4105CPK	Glycosyl transferase (Group 1
TT_C1393	ENOG4105C8Y	Acetylornithine aminotransferase
TT_C1396	ENOG4108KB0	deacetylase
TT_C1397	ENOG4105BZU	Histidine kinase
TT_C1399	ENOG4105CEP	NADH dehydrogenase
TT_C1404	ENOG4107SFQ	iron-sulfur binding
TT_C1408	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
TT_C1409	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
TT_C1415	ENOG4105CZX	twitching motility protein
TT_C1416	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
TT_C1421	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
TT_C1422	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TT_C1423	ENOG4105K46	50S ribosomal protein l27
TT_C1424	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
TT_C1432	ENOG4105D5G	Transposase
TT_C1436	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TT_C1437	ENOG4107ZT3	family UPF0126
TT_C1438	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
TT_C1441	ENOG4105CBP	Major Facilitator
TT_C1442	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
TT_C1443	ENOG4108Z5K	methylglyoxal synthase
TT_C1445	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
TT_C1446	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
TT_C1447	ENOG4105F4P	)-transporter
TT_C1451	ENOG41090A4	Pterin carbinolamine dehydratase
TT_C1454	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
TT_C1455	ENOG4105E0C	molybdate abc transporter
TT_C1456	ENOG4105C4Y	ABC transporter
TT_C1459	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
TT_C1460	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TT_C1461	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
TT_C1463	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
TT_C1464	ENOG4105DFF	Rod shape-determining protein mreb
TT_C1465	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
TT_C1466	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
TT_C1467	ENOG4108784	2'-5' rna ligase
TT_C1468	ENOG4105CEV	competence damage-inducible protein
TT_C1469	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
TT_C1473	ENOG4105DTQ	mandelate racemase muconate lactonizing
TT_C1476	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
TT_C1478	ENOG4106B0N	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
TT_C1480	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TT_C1482	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
TT_C1483	ENOG4108I0Y	(ABC) transporter
TT_C1484	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
TT_C1487	ENOG4105C3K	feS assembly ATPase SufC
TT_C1488	ENOG4105DIW	FeS assembly protein SUFB
TT_C1490	ENOG4105VQD	rieske 2fe-2S domain-containing protein
TT_C1491	ENOG4107QYG	anthranilate phosphoribosyltransferase
TT_C1492	ENOG4105DDQ	anthranilate synthase
TT_C1493	ENOG4105CRQ	synthase (Component I)
TT_C1502	ENOG4108UXE	Protein tyrosine phosphatase
TT_C1503	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TT_C1504	ENOG4105UIB	(ABC) transporter
TT_C1508	ENOG4105MA4	psp1 domain protein
TT_C1509	ENOG4107QRG	dna polymerase iii
TT_C1516	ENOG4105C22	threonyL-tRNA synthetase
TT_C1517	ENOG4105EUJ	GTP cyclohydrolase i
TT_C1518	ENOG4108Z0R	Transferase
TT_C1519	ENOG41062IR	nudix hydrolase
TT_C1521	ENOG4105CI3	gtp-binding protein typa
TT_C1523	ENOG4105D1H	recombination factor protein RarA
TT_C1525	ENOG4105DRS	transport system, permease
TT_C1526	ENOG4105C04	l-carnitine dehydratase bile acid-inducible protein F
TT_C1527	ENOG4105CJ1	ABC, transporter
TT_C1530	ENOG4105C7S	Dehydrogenase
TT_C1531	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
TT_C1532	ENOG4105ZU5	s-layer protein
TT_C1533	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
TT_C1534	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TT_C1538	ENOG4105C4K	Nad synthetase
TT_C1540	ENOG4107RFW	hydrolase family 57
TT_C1541	ENOG4107U4Q	acetylglutamate kinase
TT_C1542	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
TT_C1543	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
TT_C1544	ENOG4106928	lysine biosynthesis protein LysW
TT_C1546	ENOG4108S93	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TT_C1547	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
TT_C1550	ENOG4108JZA	Homocitrate synthase
TT_C1551	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
TT_C1552	ENOG4105C1G	acyl-Coa dehydrogenase
TT_C1553	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
TT_C1555	ENOG4105C3M	thioredoxin reductase
TT_C1558	ENOG4108SDH	ABC, transporter
TT_C1559	ENOG4108IUW	ABC transporter
TT_C1560	ENOG4108WBT	adenosyltransferase
TT_C1563	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
TT_C1564	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
TT_C1567	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
TT_C1568	ENOG4107EUI	c reductase, iron-sulfur
TT_C1570	ENOG4105D6P	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex (By similarity)
TT_C1573	ENOG4105BZ7	extracellular solute-binding protein family 1
TT_C1574	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
TT_C1575	ENOG4105C1G	acyl-Coa dehydrogenase
TT_C1577	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
TT_C1581	ENOG4105K8R	UPF0145 protein
TT_C1583	ENOG4105DXN	mazG family
TT_C1585	ENOG4107R7Y	intracellular protease Pfpi family
TT_C1586	ENOG4107RRU	Involved in both the arginine and lysine biosynthetic pathways (By similarity)
TT_C1588	ENOG4105C6E	dna polymerase iii
TT_C1589	ENOG4105VPX	protein, conserved in bacteria
TT_C1591	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
TT_C1592	ENOG4105DQU	oxidoreductase, subunit beta
TT_C1593	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
TT_C1594	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
TT_C1595	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
TT_C1597	ENOG4105CTQ	phosphohexokinase
TT_C1600	ENOG4105F0N	pyrophosphate phospho-hydrolase
TT_C1603	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
TT_C1604	ENOG4105FA0	parb-like partition protein
TT_C1605	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
TT_C1606	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
TT_C1607	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
TT_C1608	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
TT_C1609	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
TT_C1610	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
TT_C1611	ENOG4105CA9	Pyruvate kinase
TT_C1613	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
TT_C1614	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
TT_C1616	ENOG41087YS	Phage shock protein A
TT_C1619	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
TT_C1620	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
TT_C1621	ENOG4105CZX	twitching motility protein
TT_C1622	ENOG4107QHF	type ii secretion system protein e
TT_C1623	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
TT_C1624	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
TT_C1625	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TT_C1627	ENOG4107T3P	ABC, transporter
TT_C1630	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
TT_C1632	ENOG4105CSH	Transporter
TT_C1634	ENOG4105C2X	Arabinose 5-phosphate isomerase
TT_C1635	ENOG41082T9	Membrane
TT_C1636	ENOG4105C6T	cysteine synthase
TT_C1637	ENOG4108YZY	peptidylprolyl cis-trans isomerase
TT_C1638	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
TT_C1640	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
TT_C1641	ENOG4105CHM	Aminotransferase
TT_C1642	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
TT_C1647	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
TT_C1648	ENOG4105WMR	Protein CrcB homolog
TT_C1649	ENOG4105KJJ	Uncharacterized ACR, COG1993
TT_C1652	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
TT_C1655	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
TT_C1656	ENOG4105SYT	Methylenetetrahydrofolate reductase
TT_C1659	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
TT_C1660	ENOG4105C8B	TIGR00159 family
TT_C1662	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
TT_C1663	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
TT_C1664	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
TT_C1665	ENOG4105CHW	UPF0052 protein
TT_C1671	ENOG4105BZ9	Cytochrome C oxidase, subunit I
TT_C1672	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
TT_C1673	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
TT_C1676	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
TT_C1677	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
TT_C1678	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
TT_C1688	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
TT_C1690	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
TT_C1692	ENOG41080TK	Universal stress protein
TT_C1695	ENOG4105PAD	Hydrolase
TT_C1696	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
TT_C1697	ENOG4108UKI	Enoyl-CoA hydratase
TT_C1698	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
TT_C1699	ENOG4105C7S	Dehydrogenase
TT_C1701	ENOG4105CDH	Citrulline--aspartate ligase
TT_C1702	ENOG4105CH7	arginosuccinase
TT_C1706	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
TT_C1707	ENOG4105CKU	formyltetrahydrofolate synthetase
TT_C1709	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
TT_C1710	ENOG4105C89	phosphohexose isomerase
TT_C1712	ENOG4108RWN	rrna methyltransferase
TT_C1713	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
TT_C1714	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
TT_C1715	ENOG4105CTD	carboxy-peptidase
TT_C1718	ENOG4108DBC	nitroreductase
TT_C1719	ENOG4105K4H	Nlp p60 protein
TT_C1721	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
TT_C1723	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
TT_C1724	ENOG4105E2Z	phosphate ABC transporter (Permease
TT_C1725	ENOG4105C8U	phosphate abc transporter
TT_C1727	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
TT_C1729	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
TT_C1730	ENOG4105G5W	regulator Fur family
TT_C1733	ENOG4105CY0	Metallo-Beta-Lactamase
TT_C1734	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
TT_C1735	ENOG4105WDJ	50S ribosomal protein L33
TT_C1736	ENOG410683Z	Preprotein translocase SecE subunit
TT_C1737	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
TT_C1738	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
TT_C1739	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
TT_C1740	ENOG41082AW	Binds together with S18 to 16S ribosomal RNA (By similarity)
TT_C1741	ENOG4105Z8H	single-stranded DNA-binding protein
TT_C1742	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
TT_C1743	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
TT_C1744	ENOG4105DMF	Dehydrogenase
TT_C1745	ENOG4105E1F	short-chain dehydrogenase reductase
TT_C1746	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
TT_C1747	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
TT_C1753	ENOG4107QN2	dihydrolipoyl dehydrogenase
TT_C1755	ENOG4105ZVY	2-oxoisovalerate dehydrogenase, E1 component beta subunit
TT_C1756	ENOG4105CPP	Dehydrogenase, E1 component
TT_C1757	ENOG4107SUU	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
TT_C1758	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
TT_C1761	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
TT_C1762	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
TT_C1763	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
TT_C1764	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
TT_C1766	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
TT_C1767	ENOG4105FE9	pseudouridine synthase
TT_C1769	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
TT_C1770	ENOG4105DCF	alanine dehydrogenase
TT_C1772	ENOG4105DP4	dak2 domain fusion protein ylov
TT_C1774	ENOG41069ER	domain protein
TT_C1775	ENOG4105D60	lipoprotein releasing system transmembrane protein
TT_C1776	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
TT_C1777	ENOG4108VZM	50s ribosomal protein L10
TT_C1778	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
TT_C1779	ENOG4105W8H	transhydrogenase (subunit alpha
TT_C1780	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
TT_C1782	ENOG4108594	Permease of the drug metabolite transporter
TT_C1785	ENOG4105C0P	Mg chelatase subunit ChlI
TT_C1786	ENOG4108J2R	molybdopterin oxidoreductase
TT_C1787	ENOG4105EBR	Carboxylesterase
TT_C1788	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
TT_C1790	ENOG4105CH5	extracellular solute-binding protein, family 7
TT_C1791	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TT_C1793	ENOG4105C57	major facilitator superfamily
TT_C1795	ENOG4105EEI	dihydropteroate synthase
TT_C1796	ENOG4105KRF	dihydroneopterin aldolase
TT_C1798	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
TT_C1799	ENOG4108ZF3	Phosphatase
TT_C1800	ENOG4107RSM	transcriptional regulator
TT_C1801	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
TT_C1802	ENOG4107QSN	dihydrolipoamide acetyltransferase
TT_C1806	ENOG4105C0B	DNA polymerase III (alpha subunit)
TT_C1809	ENOG4108Z4U	Ferredoxin
TT_C1812	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
TT_C1813	ENOG4105C5R	Aminotransferase
TT_C1814	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
TT_C1815	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
TT_C1816	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
TT_C1819	ENOG4107Z3H	Transcriptional regulator, TetR family
TT_C1823	ENOG4105K8N	protein family UPF0079, ATPase
TT_C1824	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
TT_C1825	ENOG4105C8T	Leucyl-tRNA synthetase
TT_C1829	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
TT_C1833	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
TT_C1834	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TT_C1838	ENOG4108VAU	general secretion pathway protein G
TT_C1844	ENOG4107QHF	type ii secretion system protein e
TT_C1845	ENOG4105D7Q	type ii secretion system
TT_C1847	ENOG4105I08	Pseudouridine synthase
TT_C1848	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
TT_C1849	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TT_C1850	ENOG4105BZU	Histidine kinase
TT_C1851	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
TT_C1852	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
TT_C1854	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
TT_C1856	ENOG4107QPV	Serine Threonine protein kinase
TT_C1857	ENOG4105KME	endoribonuclease L-psp
TT_C1860	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
TT_C1861	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
TT_C1864	ENOG4105DHP	deoxycytidine triphosphate deaminase
TT_C1865	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
TT_C1866	ENOG4107ZZY	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
TT_C1867	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
TT_C1870	ENOG4105CM2	brancheD-chain amino acid aminotransferase
TT_C1871	ENOG4105DND	Transcriptional regulator
TT_C1872	ENOG4105WEF	catalase
TT_C1874	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
TT_C1875	ENOG4108UW5	maltose o-acetyltransferase
TT_C1876	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
TT_C1886	ENOG4105SFS	phosphoesterase RecJ domain protein
TT_C1888	ENOG4105E3H	phosphoglycerate mutase
TT_C1889	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
TT_C1894	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
TT_C1895	ENOG4105C1J	atp-dependent rna helicase
TT_C1904	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
TT_C1905	ENOG4105C0H	protease
TT_C1906	ENOG4105C75	arginyL-tRNA synthetase
TT_C1907	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TT_C1908	ENOG4107WFQ	NADH-quinone oxidoreductase, chain M
TT_C1909	ENOG4105D65	subunit l
TT_C1910	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TT_C1911	ENOG41087XN	oxidoreductase
TT_C1912	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TT_C1913	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
TT_C1914	ENOG4108IEH	NADH dehydrogenase subunit g
TT_C1915	ENOG4107EEP	NADH dehydrogenase (quinone) (EC 1.6.99.5)
TT_C1916	ENOG4105GKE	subunit e
TT_C1917	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TT_C1918	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TT_C1919	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
TT_C1920	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TT_C1921	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
TT_C1923	ENOG4105VIZ	double-strand break repair protein
TT_C1928	ENOG4105ECY	inositol monophosphatase
TT_C1929	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
TT_C1931	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
TT_C1933	ENOG41073R8	VanW family
TT_C1934	ENOG4105CDA	abc transporter atp-binding protein
TT_C1940	ENOG4105EU8	FAD linked oxidase domain protein
TT_C1942	ENOG4105C25	Primosomal protein n'
TT_C1947	ENOG4108ZAF	Molybdopterin
TT_C1948	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
TT_C1950	ENOG4105BZU	Histidine kinase
TT_C1951	ENOG4105CB5	ATP-dependent DNA helicase recG
TT_C1952	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
TT_C1954	ENOG4105DGU	Histone deacetylase
TT_C1957	ENOG4105CBD	Diacylglycerol kinase
TT_C1960	ENOG4105CHM	Aminotransferase
TT_C1963	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
TT_C1964	ENOG4106633	50S ribosomal protein l28
TT_C1966	ENOG4105CQB	FAD linked oxidase domain protein
TT_C1969	ENOG4105CPC	Aldo Keto reductase
TT_C1973	ENOG41064RH	membrane protein YliF
TT_C1975	ENOG4105DAN	ATP-dependent protease
TT_C1976	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
TT_C1978	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
TT_C1979	ENOG4108ZHD	aig2 family
TT_C1980	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
TT_C1982	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
TT_C1983	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
TT_C1986	ENOG4105EAH	synthase
TT_C1988	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
TT_P0001	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TT_P0002	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
TT_P0004	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
TT_P0006	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
TT_P0007	ENOG4105D9G	High-affinity
TT_P0008	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
TT_P0009	ENOG41081F0	Precorrin-8x methylmutase
TT_P0010	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
TT_P0011	ENOG4105DVK	Precorrin-2 c20-methyltransferase
TT_P0012	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
TT_P0013	ENOG4105E4R	Precorrin-3B C17-methyltransferase
TT_P0014	ENOG4108P62	biosynthesis protein (CbiG)
TT_P0015	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
TT_P0017	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
TT_P0018	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
TT_P0019	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
TT_P0022	ENOG4105CIH	Imidazole acetol-phosphate transaminase
TT_P0023	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
TT_P0024	ENOG4105G6Z	alkaline phosphatase
TT_P0025	ENOG4105CE4	GlcNAc 6-P deacetylase
TT_P0028	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
TT_P0030	ENOG4108UHU	Aldolase
TT_P0031	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
TT_P0033	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
TT_P0034	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
TT_P0037	ENOG4105CHR	reductase
TT_P0040	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
TT_P0043	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
TT_P0047	ENOG4105EWK	phytoene
TT_P0048	ENOG4105CGD	Nad-dependent epimerase dehydratase
TT_P0055	ENOG41090K0	Transcriptional regulator, Crp Fnr family
TT_P0057	ENOG4105FE1	phytoene synthase
TT_P0058	ENOG4105CVP	deoxyribo-dipyrimidine photolyase
TT_P0066	ENOG4105EWK	phytoene
TT_P0067	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
TT_P0071	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
TT_P0072	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
TT_P0079	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TT_P0083	ENOG4105FA0	parb-like partition protein
TT_P0084	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
TT_P0095	ENOG4107V8H	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)
TT_P0104	ENOG4108W8W	CRISPR-associated RAMP protein, Csm3 family
TT_P0122	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
TT_P0124	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
TT_P0128	ENOG4105C9U	ATP-dependent DNA helicase RecQ
TT_P0133	ENOG4105FB9	CRISPR-associated protein
TT_P0137	ENOG4105E7W	lamb ycsf family protein
TT_P0138	ENOG4107H9G	Necessary for formate dehydrogenase activity (By similarity)
TT_P0150	ENOG4106EQQ	Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity)
TT_P0160	ENOG4105NAU	thioesterase Superfamily protein
TT_P0162	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
TT_P0165	ENOG4105RSG	Anti-sigma-K factor RskA
TT_P0167	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
TT_P0175	ENOG4108HUF	Transporter
TT_P0177	ENOG4108IPX	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)
TT_P0178	ENOG4105EHG	Permease protein
TT_P0179	ENOG4107R4I	Periplasmic binding protein
TT_P0182	ENOG4105D5G	Transposase
TT_P0184	ENOG4106FRU	abrb family transcriptional regulator
TT_P0187	ENOG4105DQ6	Transposase
TT_P0194	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
TT_P0195	ENOG41066GP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
TT_P0216	ENOG4105DR5	peptidase
TT_P0223	ENOG4105CT4	transporter