locus-tag	class	description
TT_C0002	COG1028	Short-chain dehydrogenase reductase Sdr
TT_C0003	COG0492	ferredoxin-NADP+ reductase activity
TT_C0005	COG0792	nuclease activity
TT_C0006	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TT_C0009	COG1175	transmembrane transport
TT_C0010	COG0395	ABC-type sugar transport system, permease component
TT_C0016	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TT_C0017	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TT_C0018	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TT_C0019	COG0805	protein transport
TT_C0020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TT_C0020	COG1605	Chorismate mutase
TT_C0026	COG1028	Short-chain dehydrogenase reductase Sdr
TT_C0032	COG1063	alcohol dehydrogenase
TT_C0038	COG2255	four-way junction helicase activity
TT_C0039	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TT_C0040	COG0564	pseudouridine synthase activity
TT_C0043	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TT_C0044	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TT_C0045	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TT_C0046	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TT_C0048	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TT_C0049	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TT_C0050	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TT_C0057	COG0778	Nitroreductase
TT_C0060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TT_C0061	COG0131	Imidazoleglycerol-phosphate dehydratase
TT_C0062	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TT_C0063	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TT_C0064	COG0516	GMP reductase activity
TT_C0064	COG0517	IMP dehydrogenase activity
TT_C0067	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TT_C0070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TT_C0073	COG2890	protein-(glutamine-N5) methyltransferase activity
TT_C0075	COG0706	membrane insertase activity
TT_C0076	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TT_C0077	COG0594	ribonuclease P activity
TT_C0079	COG1022	Amp-dependent synthetase and ligase
TT_C0080	COG0559	Belongs to the binding-protein-dependent transport system permease family
TT_C0084	COG1121	(ABC) transporter
TT_C0085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TT_C0086	COG1959	2 iron, 2 sulfur cluster binding
TT_C0087	COG1104	cysteine desulfurase activity
TT_C0088	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TT_C0089	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TT_C0092	COG1028	Short-chain dehydrogenase reductase Sdr
TT_C0096	COG0492	ferredoxin-NADP+ reductase activity
TT_C0098	COG0747	negative chemotaxis
TT_C0099	COG0601	transmembrane transport
TT_C0100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TT_C0103	COG0517	IMP dehydrogenase activity
TT_C0104	COG0123	including yeast histone deacetylase and acetoin utilization protein
TT_C0105	COG2104	thiamine diphosphate biosynthetic process
TT_C0106	COG0037	tRNA processing
TT_C0107	COG0366	Alpha amylase catalytic
TT_C0108	COG2226	methyltransferase
TT_C0109	COG2226	methyltransferase
TT_C0110	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TT_C0112	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TT_C0113	COG3744	PilT protein domain protein
TT_C0115	COG0460	homoserine dehydrogenase
TT_C0117	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TT_C0123	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TT_C0127	COG0247	lactate metabolic process
TT_C0129	COG0277	FAD linked oxidase domain protein
TT_C0131	COG1414	Transcriptional regulator
TT_C0132	COG0789	Transcriptional regulator
TT_C0133	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TT_C0134	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_C0135	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TT_C0142	COG0861	Integral membrane protein TerC family
TT_C0143	COG2151	metal-sulfur cluster biosynthetic enzyme
TT_C0144	COG0281	malic enzyme
TT_C0148	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TT_C0149	COG0509	glycine decarboxylation via glycine cleavage system
TT_C0150	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT_C0151	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TT_C0152	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT_C0155	COG0243	molybdopterin cofactor binding
TT_C0159	COG0196	riboflavin kinase activity
TT_C0160	COG1051	belongs to the nudix hydrolase family
TT_C0164	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TT_C0165	COG2813	Specifically methylates the guanine in position
TT_C0166	COG0527	aspartate kinase activity
TT_C0167	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TT_C0168	COG0039	L-malate dehydrogenase activity
TT_C0172	COG4956	integral membrane protein (PIN domain superfamily)
TT_C0173	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TT_C0174	COG0542	response to heat
TT_C0175	COG0423	glycine-tRNA ligase activity
TT_C0177	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TT_C0181	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TT_C0183	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TT_C0184	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TT_C0185	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TT_C0187	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TT_C0188	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TT_C0189	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TT_C0190	COG0114	fumarate hydratase activity
TT_C0191	COG0183	Belongs to the thiolase family
TT_C0194	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TT_C0195	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TT_C0198	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TT_C0199	COG1254	Belongs to the acylphosphatase family
TT_C0201	COG1063	alcohol dehydrogenase
TT_C0202	COG2133	pyrroloquinoline quinone binding
TT_C0204	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TT_C0205	COG0154	amidase activity
TT_C0210	COG0572	uridine kinase
TT_C0211	COG3842	ATPase activity
TT_C0214	COG4475	Protein of unknown function (DUF436)
TT_C0221	COG0683	leucine binding
TT_C0225	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TT_C0226	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TT_C0227	COG0803	Belongs to the bacterial solute-binding protein 9 family
TT_C0231	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TT_C0232	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TT_C0233	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TT_C0235	COG1028	Short-chain dehydrogenase reductase Sdr
TT_C0236	COG0318	PFAM AMP-dependent synthetase and ligase
TT_C0237	COG1012	belongs to the aldehyde dehydrogenase family
TT_C0237	COG2030	dehydratase
TT_C0238	COG1960	acyl-CoA dehydrogenase activity
TT_C0241	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TT_C0242	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TT_C0244	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TT_C0246	COG3870	Protein conserved in bacteria
TT_C0247	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TT_C0249	COG0544	peptidyl-prolyl cis-trans isomerase activity
TT_C0250	COG0740	serine-type endopeptidase activity
TT_C0251	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TT_C0252	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TT_C0253	COG1410	methionine synthase
TT_C0253	COG0646	methionine synthase
TT_C0255	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TT_C0257	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TT_C0259	COG1692	metallophosphoesterase
TT_C0260	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TT_C0261	COG1970	mechanosensitive ion channel activity
TT_C0264	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TT_C0265	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TT_C0275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TT_C0279	COG1215	transferase activity, transferring glycosyl groups
TT_C0291	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TT_C0295	COG0489	protein tyrosine kinase activity
TT_C0297	COG2264	protein methyltransferase activity
TT_C0298	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TT_C0304	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TT_C0304	COG0574	Belongs to the PEP-utilizing enzyme family
TT_C0306	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TT_C0307	COG2046	Belongs to the sulfate adenylyltransferase family
TT_C0308	COG1648	precorrin-2 dehydrogenase activity
TT_C0308	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TT_C0309	COG0730	response to heat
TT_C0310	COG0175	sulfate reduction
TT_C0311	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TT_C0311	COG1648	precorrin-2 dehydrogenase activity
TT_C0312	COG1587	Uroporphyrinogen-III synthase
TT_C0313	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TT_C0315	COG0352	thiamine-phosphate diphosphorylase activity
TT_C0316	COG2104	thiamine diphosphate biosynthetic process
TT_C0317	COG2022	thiamine diphosphate biosynthetic process
TT_C0318	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TT_C0318	COG2022	thiamine diphosphate biosynthetic process
TT_C0319	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TT_C0320	COG0477	Major facilitator Superfamily
TT_C0321	COG0352	thiamine-phosphate diphosphorylase activity
TT_C0321	COG0351	phosphomethylpyrimidine kinase
TT_C0329	COG1940	carbohydrate kinase activity
TT_C0330	COG0183	Belongs to the thiolase family
TT_C0333	COG1028	Short-chain dehydrogenase reductase Sdr
TT_C0334	COG0410	ABC transporter
TT_C0337	COG0559	Belongs to the binding-protein-dependent transport system permease family
TT_C0339	COG2030	dehydratase
TT_C0341	COG0596	Alpha beta hydrolase
TT_C0342	COG0318	PFAM AMP-dependent synthetase and ligase
TT_C0343	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TT_C0345	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TT_C0345	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TT_C0347	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TT_C0349	COG0195	Participates in both transcription termination and antitermination
TT_C0350	COG0779	Required for maturation of 30S ribosomal subunits
TT_C0351	COG0739	heme binding
TT_C0352	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TT_C0353	COG0640	Transcriptional regulator
TT_C0354	COG2217	Heavy metal translocating P-type atpase
TT_C0355	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TT_C0356	COG0017	Asparaginyl-tRNA synthetase
TT_C0357	COG0561	phosphatase activity
TT_C0358	COG0384	phenazine biosynthesis protein PhzF
TT_C0359	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TT_C0360	COG0124	histidyl-tRNA synthetase
TT_C0363	COG3842	ATPase activity
TT_C0366	COG1573	uracil-dna glycosylase
TT_C0370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TT_C0371	COG0519	Catalyzes the synthesis of GMP from XMP
TT_C0371	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TT_C0373	COG1316	TRANSCRIPTIONal
TT_C0374	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TT_C0383	COG0295	cytidine deaminase activity
TT_C0385	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TT_C0387	COG1760	l-serine dehydratase
TT_C0389	COG0481	GTPase activity
TT_C0391	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TT_C0392	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TT_C0394	COG1028	Short-chain dehydrogenase reductase Sdr
TT_C0402	COG3706	GGDEF domain
TT_C0403	COG0405	Gamma-glutamyltransferase
TT_C0404	COG1073	alpha beta
TT_C0407	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TT_C0408	COG2873	o-acetylhomoserine
TT_C0411	COG1063	alcohol dehydrogenase
TT_C0414	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TT_C0416	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TT_C0417	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT_C0418	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TT_C0419	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TT_C0420	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TT_C0421	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TT_C0422	COG3300	MHYT domain
TT_C0422	COG5001	Diguanylate cyclase
TT_C0424	COG0167	dihydroorotate dehydrogenase activity
TT_C0426	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TT_C0427	COG0540	Belongs to the ATCase OTCase family
TT_C0428	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TT_C0430	COG0730	response to heat
TT_C0431	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TT_C0433	COG0312	modulator of DNA gyrase
TT_C0435	COG1960	acyl-CoA dehydrogenase activity
TT_C0436	COG0456	acetyltransferase
TT_C0438	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TT_C0439	COG0009	L-threonylcarbamoyladenylate synthase
TT_C0443	COG0277	FAD linked oxidase domain protein
TT_C0447	COG0287	Prephenate dehydrogenase
TT_C0448	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TT_C0449	COG2514	catechol 2,3-dioxygenase activity
TT_C0450	COG2353	YceI-like domain
TT_C0451	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TT_C0452	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TT_C0456	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TT_C0457	COG0179	Fumarylacetoacetate (FAA) hydrolase
TT_C0459	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TT_C0460	COG0151	Belongs to the GarS family
TT_C0461	COG5002	protein histidine kinase activity
TT_C0461	COG2176	DNA-directed DNA polymerase activity
TT_C0467	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TT_C0469	COG0217	transcriptional regulatory protein
TT_C0470	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TT_C0470	COG4651	solute:proton antiporter activity
TT_C0471	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TT_C0472	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TT_C0473	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TT_C0474	COG1674	ftsk spoiiie
TT_C0477	COG0517	IMP dehydrogenase activity
TT_C0481	COG1994	Peptidase M50
TT_C0482	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TT_C0484	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT_C0487	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TT_C0489	COG2719	SpoVR family
TT_C0490	COG2718	Belongs to the UPF0229 family
TT_C0491	COG2766	serine protein kinase
TT_C0496	COG2137	regulation of response to DNA damage stimulus
TT_C0498	COG2359	stage V sporulation protein S
TT_C0499	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TT_C0500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TT_C0502	COG0463	Glycosyl transferase, family 2
TT_C0503	COG0750	zinc metalloprotease
TT_C0504	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TT_C0505	COG4589	Belongs to the CDS family
TT_C0506	COG0233	cytoplasmic translational termination
TT_C0507	COG0528	UMP kinase activity
TT_C0508	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TT_C0509	COG0052	Belongs to the universal ribosomal protein uS2 family
TT_C0511	COG0494	nUDIX hydrolase
TT_C0517	COG0402	S-adenosylhomocysteine deaminase activity
TT_C0519	COG4948	Mandelate Racemase Muconate Lactonizing
TT_C0520	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TT_C0521	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TT_C0522	COG1811	Na channel or pump
TT_C0523	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TT_C0523	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TT_C0526	COG1215	transferase activity, transferring glycosyl groups
TT_C0528	COG1215	transferase activity, transferring glycosyl groups
TT_C0530	COG0438	transferase activity, transferring glycosyl groups
TT_C0531	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TT_C0534	COG1024	Enoyl-CoA hydratase
TT_C0534	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT_C0535	COG0183	Belongs to the thiolase family
TT_C0536	COG1960	acyl-CoA dehydrogenase activity
TT_C0537	COG0215	cysteine-tRNA ligase activity
TT_C0538	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TT_C0540	COG2738	Putative neutral zinc metallopeptidase
TT_C0543	COG1196	nuclear chromosome segregation
TT_C0546	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TT_C0547	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT_C0547	COG3153	acetyltransferase
TT_C0548	COG1268	BioY protein
TT_C0550	COG0126	phosphoglycerate kinase activity
TT_C0551	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TT_C0552	COG0824	Thioesterase
TT_C0554	COG0557	exoribonuclease II activity
TT_C0555	COG1355	regulation of microtubule-based process
TT_C0556	COG0617	tRNA 3'-terminal CCA addition
TT_C0557	COG0237	dephospho-CoA kinase activity
TT_C0559	COG0742	ribosomal rna small subunit methyltransferase
TT_C0560	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TT_C0561	COG0138	bifunctional purine biosynthesis protein purh
TT_C0562	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TT_C0564	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TT_C0581	COG0149	triose-phosphate isomerase activity
TT_C0582	COG3239	Fatty acid desaturase
TT_C0583	COG1490	D-aminoacyl-tRNA deacylase activity
TT_C0584	COG1307	EDD domain protein, DegV family
TT_C0585	COG1307	EDD domain protein, DegV family
TT_C0586	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TT_C0587	COG1510	regulation of RNA biosynthetic process
TT_C0589	COG3769	mannosylglycerate metabolic process
TT_C0591	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TT_C0593	COG1012	belongs to the aldehyde dehydrogenase family
TT_C0594	COG2368	4-hydroxyphenylacetate
TT_C0595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TT_C0598	COG0559	Belongs to the binding-protein-dependent transport system permease family
TT_C0599	COG0411	ABC transporter
TT_C0600	COG0410	ABC transporter
TT_C0601	COG2050	protein possibly involved in aromatic compounds catabolism
TT_C0602	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TT_C0604	COG1012	belongs to the aldehyde dehydrogenase family
TT_C0604	COG2030	dehydratase
TT_C0608	COG3396	Phenylacetate-CoA oxygenase
TT_C0610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TT_C0616	COG1980	fructose-bisphosphate aldolase activity
TT_C0617	COG1733	regulation of RNA biosynthetic process
TT_C0618	COG2193	ferroxidase activity
TT_C0619	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TT_C0620	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TT_C0622	COG1331	Highly conserved protein containing a thioredoxin domain
TT_C0623	COG0183	Belongs to the thiolase family
TT_C0624	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TT_C0625	COG0477	Major facilitator Superfamily
TT_C0626	COG1846	Transcriptional regulator
TT_C0627	COG2199	diguanylate cyclase activity
TT_C0628	COG5002	protein histidine kinase activity
TT_C0628	COG5001	Diguanylate cyclase
TT_C0633	COG0745	RESPONSE REGULATOR receiver
TT_C0634	COG1012	belongs to the aldehyde dehydrogenase family
TT_C0636	COG0248	Ppx GppA phosphatase
TT_C0637	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TT_C0643	COG0745	RESPONSE REGULATOR receiver
TT_C0644	COG2205	protein histidine kinase activity
TT_C0648	COG1136	(ABC) transporter
TT_C0649	COG0577	efflux transmembrane transporter activity
TT_C0649	COG1136	(ABC) transporter
TT_C0665	COG0582	viral genome integration into host DNA
TT_C0666	COG2897	thiosulfate sulfurtransferase activity
TT_C0667	COG1760	l-serine dehydratase
TT_C0668	COG2197	response regulator
TT_C0669	COG0335	large ribosomal subunit rRNA binding
TT_C0670	COG0336	Belongs to the RNA methyltransferase TrmD family
TT_C0671	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TT_C0672	COG1837	Belongs to the UPF0109 family
TT_C0673	COG0228	four-way junction DNA binding
TT_C0676	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TT_C0678	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TT_C0679	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TT_C0680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TT_C0682	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TT_C0683	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TT_C0684	COG1702	phosphate starvation-inducible protein PhoH
TT_C0686	COG4864	UPF0365 protein
TT_C0688	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TT_C0690	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TT_C0690	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TT_C0691	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TT_C0693	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TT_C0694	COG1397	ADP-ribosylglycohydrolase
TT_C0695	COG2239	Acts as a magnesium transporter
TT_C0697	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TT_C0697	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TT_C0699	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TT_C0699	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TT_C0700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TT_C0701	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TT_C0702	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TT_C0703	COG0006	proline dipeptidase activity
TT_C0705	COG0739	heme binding
TT_C0707	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TT_C0708	COG0254	rRNA binding
TT_C0710	COG2001	Belongs to the MraZ family
TT_C0711	COG0275	rRNA processing
TT_C0713	COG0768	penicillin binding
TT_C0714	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TT_C0716	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TT_C0717	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TT_C0718	COG0772	Belongs to the SEDS family
TT_C0719	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TT_C0720	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TT_C0721	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TT_C0725	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TT_C0727	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TT_C0729	COG0159	tryptophan synthase activity
TT_C0730	COG0133	tryptophan synthase activity
TT_C0731	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TT_C0732	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TT_C0745	COG0438	transferase activity, transferring glycosyl groups
TT_C0746	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TT_C0748	COG0039	L-malate dehydrogenase activity
TT_C0749	COG2819	hydrolase of the alpha beta superfamily
TT_C0750	COG0861	Integral membrane protein TerC family
TT_C0752	COG2181	nitrate reductase activity
TT_C0752	COG0247	lactate metabolic process
TT_C0754	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TT_C0755	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TT_C0756	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TT_C0758	COG0439	Biotin carboxylase
TT_C0759	COG0511	ligase activity, forming carbon-carbon bonds
TT_C0760	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TT_C0764	COG0010	Belongs to the arginase family
TT_C0767	COG1100	Small GTP-binding protein
TT_C0769	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TT_C0770	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TT_C0772	COG2814	Major facilitator Superfamily
TT_C0773	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TT_C0774	COG1185	polyribonucleotide nucleotidyltransferase activity
TT_C0775	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TT_C0777	COG0745	RESPONSE REGULATOR receiver
TT_C0778	COG5002	protein histidine kinase activity
TT_C0779	COG1960	acyl-CoA dehydrogenase activity
TT_C0780	COG2086	electron transfer activity
TT_C0781	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TT_C0783	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TT_C0784	COG1573	uracil-dna glycosylase
TT_C0785	COG1796	DNA polymerase
TT_C0785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TT_C0788	COG2309	aminopeptidase activity
TT_C0792	COG2873	o-acetylhomoserine
TT_C0795	COG1126	abc transporter atp-binding protein
TT_C0797	COG1752	Esterase of the alpha-beta hydrolase superfamily
TT_C0798	COG3311	Transcriptional regulator
TT_C0800	COG0134	indole-3-glycerol-phosphate synthase activity
TT_C0801	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TT_C0803	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TT_C0805	COG0525	valine-tRNA ligase activity
TT_C0806	COG0765	amino acid transport
TT_C0807	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TT_C0809	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TT_C0810	COG0569	domain protein
TT_C0811	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TT_C0812	COG1426	Protein conserved in bacteria
TT_C0813	COG2313	pseudouridylate synthase activity
TT_C0816	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TT_C0818	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TT_C0822	COG0012	GTP binding
TT_C0823	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TT_C0825	COG0424	maF-like protein
TT_C0828	COG0768	penicillin binding
TT_C0835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TT_C0836	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TT_C0838	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TT_C0841	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TT_C0843	COG1131	(ABC) transporter
TT_C0847	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TT_C0850	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TT_C0851	COG0440	acetolactate synthase activity
TT_C0852	COG0028	Belongs to the TPP enzyme family
TT_C0853	COG0492	ferredoxin-NADP+ reductase activity
TT_C0858	COG2165	general secretion pathway protein
TT_C0860	COG4636	protein conserved in cyanobacteria
TT_C0864	COG0180	Tryptophanyl-tRNA synthetase
TT_C0865	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TT_C0866	COG0066	3-isopropylmalate dehydratase activity
TT_C0867	COG0473	3-isopropylmalate dehydrogenase activity
TT_C0870	COG0300	oxidoreductase activity
TT_C0871	COG0129	dihydroxy-acid dehydratase activity
TT_C0873	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TT_C0874	COG1177	transmembrane transport
TT_C0875	COG1176	ABC-type spermidine putrescine transport system, permease component I
TT_C0876	COG3842	ATPase activity
TT_C0877	COG0772	Belongs to the SEDS family
TT_C0878	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TT_C0879	COG2894	cell division
TT_C0880	COG1733	regulation of RNA biosynthetic process
TT_C0884	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_C0885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_C0886	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_C0887	COG0653	protein targeting
TT_C0888	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TT_C0892	COG0393	Putative heavy-metal-binding
TT_C0893	COG1111	helicase
TT_C0893	COG1205	dead DEAH box helicase
TT_C0896	COG0358	DNA primase activity
TT_C0898	COG1250	3-hydroxyacyl-CoA dehydrogenase
TT_C0899	COG0697	spore germination
TT_C0900	COG0612	Peptidase, M16
TT_C0901	COG0612	Peptidase, M16
TT_C0902	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TT_C0905	COG1394	ATPase activity, coupled to movement of substances
TT_C0906	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TT_C0907	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TT_C0908	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TT_C0909	COG1527	subunit (C
TT_C0910	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TT_C0912	COG1269	ATP hydrolysis coupled proton transport
TT_C0917	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TT_C0919	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TT_C0922	COG0419	ATPase involved in DNA repair
TT_C0923	COG0420	3'-5' exonuclease activity
TT_C0927	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TT_C0928	COG2884	Cell division ATP-binding protein ftsE
TT_C0929	COG0793	Belongs to the peptidase S41A family
TT_C0931	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_C0931	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_C0932	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TT_C0933	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TT_C0938	COG1129	ABC transporter
TT_C0939	COG0746	molybdenum cofactor guanylyltransferase activity
TT_C0942	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TT_C0946	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TT_C0947	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TT_C0948	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TT_C0950	COG1994	Peptidase M50
TT_C0950	COG0517	IMP dehydrogenase activity
TT_C0956	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT_C0957	COG0788	formyltetrahydrofolate deformylase activity
TT_C0958	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TT_C0959	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TT_C0960	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TT_C0962	COG2010	Cytochrome c
TT_C0964	COG0737	Belongs to the 5'-nucleotidase family
TT_C0965	COG0174	glutamine synthetase
TT_C0967	COG0559	Belongs to the binding-protein-dependent transport system permease family
TT_C0971	COG0747	negative chemotaxis
TT_C0975	COG0285	dihydrofolate synthase activity
TT_C0976	COG1132	(ABC) transporter
TT_C0977	COG1132	(ABC) transporter
TT_C0978	COG0372	Belongs to the citrate synthase family
TT_C0979	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TT_C0980	COG1482	cell wall glycoprotein biosynthetic process
TT_C0982	COG1515	deoxyribonuclease V activity
TT_C0984	COG0776	regulation of translation
TT_C0987	COG2197	response regulator
TT_C0988	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TT_C0989	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TT_C0990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TT_C0991	COG1324	tolerance protein
TT_C0994	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT_C0998	COG2205	protein histidine kinase activity
TT_C1000	COG0247	lactate metabolic process
TT_C1001	COG1139	Iron-sulfur cluster binding protein
TT_C1002	COG1556	Lactate utilization protein
TT_C1004	COG1752	Esterase of the alpha-beta hydrolase superfamily
TT_C1005	COG2815	serine threonine protein kinase
TT_C1005	COG0515	serine threonine protein kinase
TT_C1006	COG0860	N-Acetylmuramoyl-L-alanine amidase
TT_C1008	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TT_C1012	COG0473	3-isopropylmalate dehydrogenase activity
TT_C1017	COG1450	Type ii and iii secretion system protein
TT_C1018	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TT_C1019	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TT_C1020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TT_C1021	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TT_C1021	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TT_C1022	COG0736	holo-[acyl-carrier-protein] synthase activity
TT_C1025	COG1160	GTP binding
TT_C1026	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TT_C1027	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TT_C1027	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TT_C1028	COG0083	homoserine kinase activity
TT_C1031	COG0268	Binds directly to 16S ribosomal RNA
TT_C1033	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TT_C1034	COG0723	plastoquinol--plastocyanin reductase activity
TT_C1036	COG4235	cytochrome complex assembly
TT_C1036	COG3088	subunit of a heme lyase
TT_C1037	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TT_C1038	COG1138	Cytochrome C-type biogenesis protein
TT_C1039	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TT_C1041	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TT_C1042	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TT_C1043	COG4133	protoheme IX ABC transporter activity
TT_C1044	COG0785	Cytochrome C biogenesis protein
TT_C1045	COG3258	Cytochrome c
TT_C1047	COG0446	pyridine nucleotide-disulphide oxidoreductase
TT_C1050	COG3258	Cytochrome c
TT_C1051	COG2010	Cytochrome c
TT_C1052	COG0737	Belongs to the 5'-nucleotidase family
TT_C1053	COG2010	Cytochrome c
TT_C1054	COG3258	Cytochrome c
TT_C1058	COG2010	Cytochrome c
TT_C1059	COG3842	ATPase activity
TT_C1065	COG0318	PFAM AMP-dependent synthetase and ligase
TT_C1066	COG3360	Dodecin
TT_C1069	COG1024	Enoyl-CoA hydratase
TT_C1070	COG0813	purine-nucleoside phosphorylase activity
TT_C1071	COG1136	(ABC) transporter
TT_C1072	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT_C1073	COG2045	Belongs to the ComB family
TT_C1075	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TT_C1077	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TT_C1079	COG0107	imidazoleglycerol-phosphate synthase activity
TT_C1080	COG0140	phosphoribosyl-ATP diphosphatase activity
TT_C1080	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TT_C1081	COG1494	fructose-1,6-bisphosphatase
TT_C1082	COG0686	Belongs to the AlaDH PNT family
TT_C1083	COG0427	acetyl-CoA hydrolase
TT_C1084	COG0084	hydrolase, TatD family'
TT_C1085	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TT_C1087	COG0017	Asparaginyl-tRNA synthetase
TT_C1089	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TT_C1090	COG1053	succinate dehydrogenase
TT_C1092	COG2009	succinate dehydrogenase
TT_C1093	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TT_C1099	COG0318	PFAM AMP-dependent synthetase and ligase
TT_C1100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TT_C1101	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TT_C1102	COG0504	CTP synthase activity
TT_C1104	COG0067	glutamate synthase
TT_C1104	COG0069	glutamate synthase activity
TT_C1104	COG0070	glutamate synthase
TT_C1105	COG0840	transmembrane signaling receptor activity
TT_C1106	COG0305	Participates in initiation and elongation during chromosome replication
TT_C1108	COG0475	glutathione-regulated potassium exporter activity
TT_C1109	COG0517	IMP dehydrogenase activity
TT_C1109	COG0516	GMP reductase activity
TT_C1112	COG0475	glutathione-regulated potassium exporter activity
TT_C1113	COG0490	domain, Protein
TT_C1117	COG3118	belongs to the thioredoxin family
TT_C1123	COG0542	response to heat
TT_C1124	COG0789	Transcriptional regulator
TT_C1125	COG0484	heat shock protein binding
TT_C1126	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TT_C1127	COG0443	Heat shock 70 kDa protein
TT_C1128	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TT_C1129	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TT_C1130	COG0616	signal peptide processing
TT_C1133	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TT_C1134	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TT_C1135	COG0714	Associated with various cellular activities
TT_C1136	COG0574	Belongs to the PEP-utilizing enzyme family
TT_C1136	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TT_C1137	COG1272	protein, Hemolysin III
TT_C1139	COG5002	protein histidine kinase activity
TT_C1139	COG3850	Histidine kinase
TT_C1142	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TT_C1149	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TT_C1151	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TT_C1153	COG0047	phosphoribosylformylglycinamidine synthase activity
TT_C1155	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TT_C1156	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TT_C1157	COG0116	Belongs to the methyltransferase superfamily
TT_C1160	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TT_C1161	COG0497	DNA recombination
TT_C1163	COG0604	alcohol dehydrogenase
TT_C1167	COG0585	pseudouridine synthase activity
TT_C1171	COG0557	exoribonuclease II activity
TT_C1172	COG0473	3-isopropylmalate dehydrogenase activity
TT_C1176	COG0590	tRNA wobble adenosine to inosine editing
TT_C1176	COG0037	tRNA processing
TT_C1180	COG2050	protein possibly involved in aromatic compounds catabolism
TT_C1182	COG0322	excinuclease ABC activity
TT_C1184	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TT_C1185	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TT_C1186	COG1854	S-ribosylhomocysteine lyase activity
TT_C1187	COG0519	Catalyzes the synthesis of GMP from XMP
TT_C1187	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TT_C1189	COG4274	PFAM GYD family protein
TT_C1191	COG0328	RNA-DNA hybrid ribonuclease activity
TT_C1192	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TT_C1193	COG2095	MarC family integral membrane protein
TT_C1194	COG1438	arginine binding
TT_C1195	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TT_C1196	COG1758	RNA polymerase activity
TT_C1197	COG0194	GDP metabolic process
TT_C1199	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TT_C1200	COG2385	sporulation resulting in formation of a cellular spore
TT_C1201	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TT_C1203	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TT_C1211	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TT_C1212	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TT_C1213	COG1012	belongs to the aldehyde dehydrogenase family
TT_C1214	COG0506	proline dehydrogenase activity
TT_C1219	COG0156	8-amino-7-oxononanoate synthase activity
TT_C1220	COG0732	type I restriction modification DNA specificity domain
TT_C1220	COG0827	DNA restriction-modification system
TT_C1222	COG0187	DNA topoisomerase II activity
TT_C1223	COG1181	Belongs to the D-alanine--D-alanine ligase family
TT_C1224	COG0193	aminoacyl-tRNA hydrolase activity
TT_C1225	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TT_C1230	COG0515	serine threonine protein kinase
TT_C1230	COG2815	serine threonine protein kinase
TT_C1231	COG0631	protein serine/threonine phosphatase activity
TT_C1234	COG0113	porphobilinogen synthase activity
TT_C1235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TT_C1236	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TT_C1241	COG0823	Involved in the tonB-independent uptake of proteins
TT_C1241	COG1506	peptidase
TT_C1241	COG4946	Tricorn protease homolog
TT_C1242	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TT_C1243	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TT_C1247	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TT_C1248	COG1011	Hydrolase
TT_C1253	COG0537	adenosine 5'-monophosphoramidase activity
TT_C1254	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TT_C1255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TT_C1256	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TT_C1257	COG0071	Belongs to the small heat shock protein (HSP20) family
TT_C1258	COG2897	thiosulfate sulfurtransferase activity
TT_C1259	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TT_C1261	COG1764	response to oxidative stress
TT_C1266	COG3842	ATPase activity
TT_C1267	COG0101	tRNA pseudouridine synthase activity
TT_C1268	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TT_C1270	COG0601	transmembrane transport
TT_C1271	COG0747	negative chemotaxis
TT_C1273	COG0006	proline dipeptidase activity
TT_C1274	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TT_C1277	COG1166	arginine decarboxylase activity
TT_C1278	COG3706	GGDEF domain
TT_C1279	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TT_C1280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TT_C1281	COG1611	Belongs to the LOG family
TT_C1282	COG1193	negative regulation of DNA recombination
TT_C1283	COG0366	Alpha amylase catalytic
TT_C1286	COG3833	ABC-type maltose transport systems, permease component
TT_C1287	COG1175	transmembrane transport
TT_C1290	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TT_C1291	COG0142	geranyltranstransferase activity
TT_C1299	COG0203	ribosomal protein L17
TT_C1300	COG0202	RNA polymerase activity
TT_C1301	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TT_C1302	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TT_C1303	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TT_C1304	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TT_C1305	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TT_C1307	COG0563	adenylate kinase activity
TT_C1308	COG0201	protein transport
TT_C1309	COG0200	Binds to the 23S rRNA
TT_C1310	COG1841	ribosomal large subunit assembly
TT_C1311	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TT_C1312	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TT_C1313	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TT_C1314	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TT_C1315	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TT_C1316	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TT_C1317	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TT_C1319	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TT_C1320	COG0255	Belongs to the universal ribosomal protein uL29 family
TT_C1321	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TT_C1322	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TT_C1323	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TT_C1324	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TT_C1325	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TT_C1326	COG0089	rRNA binding
TT_C1327	COG0088	Forms part of the polypeptide exit tunnel
TT_C1328	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TT_C1329	COG0051	transcription antitermination factor activity, RNA binding
TT_C1330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TT_C1331	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TT_C1332	COG0049	tRNA binding
TT_C1333	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TT_C1335	COG0442	prolyl-tRNA aminoacylation
TT_C1339	COG1115	amino acid carrier protein
TT_C1343	COG1489	DNA binding
TT_C1351	COG0432	Pfam Uncharacterised protein family UPF0047
TT_C1353	COG0668	transmembrane transport
TT_C1355	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TT_C1356	COG2217	Heavy metal translocating P-type atpase
TT_C1360	COG0745	RESPONSE REGULATOR receiver
TT_C1361	COG2205	protein histidine kinase activity
TT_C1366	COG2226	methyltransferase
TT_C1370	COG2132	Multicopper oxidase
TT_C1373	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TT_C1374	COG0822	iron-sulfur transferase activity
TT_C1378	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TT_C1380	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TT_C1381	COG0284	orotidine-5'-phosphate decarboxylase activity
TT_C1382	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TT_C1384	COG0416	fatty acid biosynthetic process
TT_C1385	COG3118	belongs to the thioredoxin family
TT_C1386	COG1185	polyribonucleotide nucleotidyltransferase activity
TT_C1389	COG0438	transferase activity, transferring glycosyl groups
TT_C1393	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TT_C1396	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TT_C1397	COG3706	GGDEF domain
TT_C1399	COG1252	NADH dehydrogenase
TT_C1404	COG0437	4 iron, 4 sulfur cluster binding
TT_C1408	COG0825	malonyl-CoA metabolic process
TT_C1409	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TT_C1416	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TT_C1421	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TT_C1422	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TT_C1423	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TT_C1424	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TT_C1432	COG3328	transposase activity
TT_C1436	COG0315	cyclic pyranopterin monophosphate synthase activity
TT_C1437	COG2860	membrane
TT_C1438	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TT_C1441	COG0477	Major facilitator Superfamily
TT_C1442	COG1694	Mazg nucleotide pyrophosphohydrolase
TT_C1443	COG1803	Methylglyoxal synthase
TT_C1445	COG0301	tRNA thio-modification
TT_C1446	COG0154	amidase activity
TT_C1447	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TT_C1451	COG2154	pterin-4-alpha-carbinolamine dehydratase
TT_C1452	COG1607	acyl-coa hydrolase
TT_C1454	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TT_C1455	COG4149	molybdate abc transporter
TT_C1456	COG1840	ABC-type Fe3 transport system, periplasmic component
TT_C1459	COG0235	Class ii aldolase
TT_C1460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TT_C1461	COG0085	RNA polymerase activity
TT_C1463	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TT_C1464	COG1077	Cell shape determining protein MreB Mrl
TT_C1465	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TT_C1465	COG1418	mRNA catabolic process
TT_C1466	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TT_C1467	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TT_C1468	COG1546	Belongs to the CinA family
TT_C1468	COG1058	Belongs to the CinA family
TT_C1469	COG0354	folic acid binding
TT_C1473	COG4948	Mandelate Racemase Muconate Lactonizing
TT_C1476	COG1175	transmembrane transport
TT_C1478	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TT_C1480	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TT_C1482	COG0577	efflux transmembrane transporter activity
TT_C1482	COG1136	(ABC) transporter
TT_C1483	COG4181	ATPase activity
TT_C1484	COG0446	pyridine nucleotide-disulphide oxidoreductase
TT_C1487	COG0396	ATPase activity
TT_C1488	COG0719	Fe-S assembly protein
TT_C1489	COG0719	Fe-S assembly protein
TT_C1490	COG2146	nitrite reductase [NAD(P)H] activity
TT_C1491	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TT_C1492	COG0512	Glutamine amidotransferase of anthranilate synthase
TT_C1493	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TT_C1502	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TT_C1503	COG2226	methyltransferase
TT_C1508	COG1774	PSP1 C-terminal conserved region
TT_C1509	COG0470	DNA polymerase III
TT_C1516	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TT_C1517	COG0302	gtp cyclohydrolase
TT_C1523	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TT_C1525	COG0395	ABC-type sugar transport system, permease component
TT_C1526	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TT_C1527	COG1131	(ABC) transporter
TT_C1531	COG0556	nucleotide-excision repair
TT_C1532	COG0497	DNA recombination
TT_C1533	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TT_C1534	COG0445	tRNA wobble uridine modification
TT_C1539	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TT_C1539	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TT_C1540	COG1543	Belongs to the glycosyl hydrolase 57 family
TT_C1541	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TT_C1542	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TT_C1543	COG0189	ligase activity
TT_C1546	COG0066	3-isopropylmalate dehydratase activity
TT_C1547	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TT_C1551	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TT_C1552	COG1960	acyl-CoA dehydrogenase activity
TT_C1553	COG0163	prenyltransferase activity
TT_C1558	COG1668	transmembrane transport
TT_C1559	COG4555	ABC transporter
TT_C1560	COG2096	Adenosyltransferase
TT_C1563	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TT_C1564	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TT_C1567	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TT_C1568	COG0723	plastoquinol--plastocyanin reductase activity
TT_C1573	COG1653	transport
TT_C1574	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TT_C1575	COG1960	acyl-CoA dehydrogenase activity
TT_C1577	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TT_C1581	COG0393	Putative heavy-metal-binding
TT_C1583	COG3956	TIGRFAM MazG family protein
TT_C1585	COG0693	protein deglycase activity
TT_C1586	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TT_C1588	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TT_C1589	COG1937	Protein conserved in bacteria
TT_C1591	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TT_C1591	COG0674	pyruvate-flavodoxin oxidoreductase activity
TT_C1592	COG1013	pyruvate-flavodoxin oxidoreductase activity
TT_C1593	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TT_C1594	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TT_C1595	COG0072	phenylalanine-tRNA ligase activity
TT_C1595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TT_C1597	COG0205	6-phosphofructokinase activity
TT_C1598	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TT_C1600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TT_C1603	COG2333	competence protein COMEC
TT_C1603	COG0658	competence protein
TT_C1604	COG1475	DNA binding
TT_C1605	COG1192	Involved in chromosome partitioning
TT_C1606	COG0357	Ribosomal RNA small subunit methyltransferase G
TT_C1607	COG0445	tRNA wobble uridine modification
TT_C1608	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TT_C1609	COG0592	DNA-directed DNA polymerase activity
TT_C1610	COG0148	phosphopyruvate hydratase activity
TT_C1611	COG0469	pyruvate kinase activity
TT_C1613	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TT_C1614	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TT_C1616	COG1842	Phage shock protein A
TT_C1619	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TT_C1620	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TT_C1622	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TT_C1623	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TT_C1625	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TT_C1626	COG1278	Cold shock
TT_C1627	COG1653	transport
TT_C1630	COG0033	Phosphoglucomutase
TT_C1632	COG0477	Major facilitator Superfamily
TT_C1634	COG0517	IMP dehydrogenase activity
TT_C1634	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TT_C1635	COG1950	PFAM Membrane protein of
TT_C1636	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TT_C1638	COG0181	hydroxymethylbilane synthase activity
TT_C1640	COG0285	dihydrofolate synthase activity
TT_C1641	COG0436	Aminotransferase
TT_C1642	COG0521	Mo-molybdopterin cofactor biosynthetic process
TT_C1647	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TT_C1648	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TT_C1649	COG1993	acr, cog1993
TT_C1650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TT_C1652	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TT_C1654	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TT_C1655	COG1335	isochorismatase
TT_C1656	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TT_C1659	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TT_C1660	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TT_C1662	COG0242	peptide deformylase activity
TT_C1663	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TT_C1664	COG1660	Displays ATPase and GTPase activities
TT_C1665	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TT_C1671	COG1845	cytochrome c oxidase, subunit III
TT_C1671	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TT_C1673	COG0109	protoheme IX farnesyltransferase activity
TT_C1673	COG1612	heme a metabolic process
TT_C1676	COG0343	queuine tRNA-ribosyltransferase activity
TT_C1677	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TT_C1678	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TT_C1688	COG1940	carbohydrate kinase activity
TT_C1690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TT_C1691	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT_C1692	COG0589	response to stress
TT_C1693	COG1611	Belongs to the LOG family
TT_C1695	COG1011	Hydrolase
TT_C1696	COG0632	four-way junction helicase activity
TT_C1697	COG1024	Enoyl-CoA hydratase
TT_C1699	COG0508	dehydrogenase complex catalyzes the overall conversion of
TT_C1701	COG0137	argininosuccinate synthase activity
TT_C1702	COG0165	Argininosuccinate lyase
TT_C1706	COG0505	Belongs to the CarA family
TT_C1707	COG2759	Belongs to the formate--tetrahydrofolate ligase family
TT_C1709	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TT_C1710	COG0166	Belongs to the GPI family
TT_C1712	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT_C1713	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TT_C1714	COG0459	protein refolding
TT_C1715	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TT_C1716	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TT_C1718	COG0778	Nitroreductase
TT_C1719	COG0791	NLP P60 protein
TT_C1719	COG1388	LysM domain
TT_C1721	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TT_C1723	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TT_C1724	COG0581	inorganic phosphate transmembrane transporter activity
TT_C1725	COG0573	inorganic phosphate transmembrane transporter activity
TT_C1726	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TT_C1727	COG0482	sulfurtransferase activity
TT_C1729	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TT_C1730	COG0735	belongs to the Fur family
TT_C1733	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TT_C1734	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TT_C1735	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TT_C1736	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TT_C1737	COG0250	Participates in transcription elongation, termination and antitermination
TT_C1738	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TT_C1739	COG0081	regulation of translation
TT_C1740	COG0360	Binds together with S18 to 16S ribosomal RNA
TT_C1741	COG0629	single-stranded DNA binding
TT_C1742	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TT_C1743	COG0359	binds to the 23S rRNA
TT_C1745	COG0300	oxidoreductase activity
TT_C1746	COG0321	lipoyl(octanoyl) transferase activity
TT_C1747	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TT_C1753	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TT_C1755	COG1598	PFAM Uncharacterised protein family UPF0150
TT_C1756	COG0022	dehydrogenase e1 component
TT_C1757	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TT_C1758	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TT_C1763	COG2226	methyltransferase
TT_C1764	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TT_C1767	COG1187	pseudouridine synthase activity
TT_C1769	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TT_C1770	COG0686	Belongs to the AlaDH PNT family
TT_C1772	COG1461	Dihydroxyacetone kinase
TT_C1774	COG3583	domain protein
TT_C1774	COG3584	3D domain protein
TT_C1775	COG4591	ABC-type transport system involved in lipoprotein release permease component
TT_C1776	COG0222	ribosome binding
TT_C1777	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TT_C1778	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TT_C1779	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TT_C1780	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TT_C1782	COG0697	spore germination
TT_C1784	COG3177	Filamentation induced by cAMP protein fic
TT_C1786	COG0243	molybdopterin cofactor binding
TT_C1787	COG2272	Belongs to the type-B carboxylesterase lipase family
TT_C1788	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TT_C1790	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TT_C1793	COG0477	Major facilitator Superfamily
TT_C1796	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TT_C1798	COG0105	UTP biosynthetic process
TT_C1799	COG0631	protein serine/threonine phosphatase activity
TT_C1800	COG0583	DNA-binding transcription factor activity
TT_C1801	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TT_C1802	COG0508	dehydrogenase complex catalyzes the overall conversion of
TT_C1809	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TT_C1811	COG1278	Cold shock
TT_C1812	COG0484	heat shock protein binding
TT_C1813	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TT_C1814	COG1968	undecaprenyl-diphosphatase activity
TT_C1815	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TT_C1816	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TT_C1819	COG1309	transcriptional regulator
TT_C1820	COG4242	Belongs to the peptidase S51 family
TT_C1823	COG0802	atpase or kinase
TT_C1824	COG0539	negative regulation of cytoplasmic translation
TT_C1825	COG0495	leucyl-tRNA aminoacylation
TT_C1829	COG1902	pentaerythritol trinitrate reductase activity
TT_C1834	COG2414	aldehyde ferredoxin oxidoreductase
TT_C1838	COG2165	general secretion pathway protein
TT_C1845	COG1459	type II secretion system
TT_C1847	COG1187	pseudouridine synthase activity
TT_C1848	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TT_C1849	COG0745	RESPONSE REGULATOR receiver
TT_C1850	COG4191	Histidine kinase
TT_C1851	COG0704	Plays a role in the regulation of phosphate uptake
TT_C1852	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TT_C1854	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TT_C1856	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TT_C1856	COG0515	serine threonine protein kinase
TT_C1860	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TT_C1861	COG1028	Short-chain dehydrogenase reductase Sdr
TT_C1864	COG0717	Belongs to the dCTP deaminase family
TT_C1865	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TT_C1866	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TT_C1867	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TT_C1871	COG0583	DNA-binding transcription factor activity
TT_C1872	COG3546	catalase activity
TT_C1873	COG0758	DNA mediated transformation
TT_C1873	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TT_C1874	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TT_C1876	COG0582	viral genome integration into host DNA
TT_C1886	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TT_C1888	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TT_C1889	COG0442	prolyl-tRNA aminoacylation
TT_C1890	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TT_C1894	COG0303	'Molybdopterin
TT_C1895	COG0513	Belongs to the DEAD box helicase family
TT_C1898	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TT_C1901	COG2070	2-Nitropropane dioxygenase
TT_C1904	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TT_C1905	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TT_C1906	COG0018	arginyl-trna synthetase
TT_C1907	COG1007	ATP synthesis coupled electron transport
TT_C1908	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_C1909	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TT_C1910	COG0713	ATP synthesis coupled electron transport
TT_C1911	COG0839	Belongs to the complex I subunit 6 family
TT_C1912	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_C1913	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TT_C1914	COG1034	ATP synthesis coupled electron transport
TT_C1915	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TT_C1916	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TT_C1917	COG0649	NAD binding
TT_C1918	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_C1919	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_C1920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TT_C1921	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TT_C1923	COG4712	double-strand break repair protein
TT_C1926	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TT_C1929	COG0135	phosphoribosylanthranilate isomerase activity
TT_C1931	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TT_C1933	COG2720	vancomycin resistance protein
TT_C1940	COG0277	FAD linked oxidase domain protein
TT_C1942	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TT_C1944	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TT_C1947	COG0314	molybdopterin synthase activity
TT_C1948	COG1420	regulation of RNA biosynthetic process
TT_C1949	COG0347	Belongs to the P(II) protein family
TT_C1950	COG0004	ammonium transporteR
TT_C1952	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TT_C1954	COG0123	including yeast histone deacetylase and acetoin utilization protein
TT_C1957	COG1597	lipid kinase activity
TT_C1962	COG0475	glutathione-regulated potassium exporter activity
TT_C1962	COG0569	domain protein
TT_C1964	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TT_C1966	COG0277	FAD linked oxidase domain protein
TT_C1969	COG0667	Aldo Keto reductase
TT_C1973	COG2199	diguanylate cyclase activity
TT_C1975	COG1067	ATP-dependent peptidase activity
TT_C1976	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TT_C1978	COG0745	RESPONSE REGULATOR receiver
TT_C1979	COG2105	PFAM AIG2 family protein
TT_C1980	COG0297	glycogen (starch) synthase activity
TT_C1982	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TT_C1983	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TT_C1986	COG0142	geranyltranstransferase activity
TT_C1988	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TT_P0001	COG1797	cobyrinic acid a,c-diamide synthase activity
TT_P0002	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TT_P0004	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TT_P0006	COG0588	phosphoglycerate mutase activity
TT_P0007	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TT_P0008	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TT_P0017	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TT_P0017	COG1648	precorrin-2 dehydrogenase activity
TT_P0018	COG0778	Nitroreductase
TT_P0022	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TT_P0023	COG1492	cobalamin metabolic process
TT_P0024	COG1785	Belongs to the alkaline phosphatase family
TT_P0025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TT_P0028	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TT_P0030	COG0800	Aldolase
TT_P0031	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TT_P0033	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TT_P0034	COG1028	Short-chain dehydrogenase reductase Sdr
TT_P0037	COG1028	Short-chain dehydrogenase reductase Sdr
TT_P0040	COG1175	transmembrane transport
TT_P0042	COG2723	6-phospho-beta-galactosidase activity
TT_P0043	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TT_P0047	COG1233	COG1233 Phytoene dehydrogenase and related
TT_P0048	COG0702	epimerase
TT_P0055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TT_P0057	COG1562	ergosterol biosynthetic process
TT_P0058	COG0415	Belongs to the DNA photolyase family
TT_P0059	COG2124	cytochrome p450
TT_P0065	COG1487	ribonuclease activity
TT_P0067	COG1304	FMN binding
TT_P0071	COG1085	galactose-1-phosphate uridylyltransferase
TT_P0072	COG3345	alpha-galactosidase
TT_P0083	COG1475	DNA binding
TT_P0084	COG1192	Involved in chromosome partitioning
TT_P0095	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TT_P0101	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TT_P0104	COG1337	RAMP superfamily
TT_P0122	COG2414	aldehyde ferredoxin oxidoreductase
TT_P0124	COG1110	DNA topoisomerase II activity
TT_P0128	COG0514	ATP-dependent DNA helicase (RecQ)
TT_P0137	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TT_P0138	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TT_P0150	COG2329	Antibiotic biosynthesis monooxygenase
TT_P0160	COG1607	acyl-coa hydrolase
TT_P0162	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TT_P0175	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
TT_P0177	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TT_P0178	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TT_P0179	COG4558	Periplasmic binding protein
TT_P0182	COG3328	transposase activity
TT_P0184	COG2002	toxin-antitoxin pair type II binding
TT_P0187	COG2801	Transposase and inactivated derivatives
TT_P0195	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TT_P0216	COG0739	heme binding
TT_P0219	COG2211	Major facilitator Superfamily
TT_P0223	COG2211	Major facilitator Superfamily