locus-tag	class	description
TthHB5002_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthHB5002_00020	COG0592	DNA-directed DNA polymerase activity
TthHB5002_00030	COG0148	phosphopyruvate hydratase activity
TthHB5002_00040	COG0469	pyruvate kinase activity
TthHB5002_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHB5002_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthHB5002_00090	COG1842	Phage shock protein A
TthHB5002_00100	COG0406	alpha-ribazole phosphatase activity
TthHB5002_00110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthHB5002_00120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5002_00140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthHB5002_00150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthHB5002_00160	COG1496	oxidoreductase activity
TthHB5002_00170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthHB5002_00180	COG1278	Cold shock
TthHB5002_00190	COG1653	transport
TthHB5002_00220	COG0033	Phosphoglucomutase
TthHB5002_00270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthHB5002_00270	COG0517	IMP dehydrogenase activity
TthHB5002_00280	COG1950	PFAM Membrane protein of
TthHB5002_00290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthHB5002_00310	COG0181	hydroxymethylbilane synthase activity
TthHB5002_00330	COG0285	dihydrofolate synthase activity
TthHB5002_00340	COG0436	Aminotransferase
TthHB5002_00350	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthHB5002_00400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthHB5002_00410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthHB5002_00420	COG1993	acr, cog1993
TthHB5002_00430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthHB5002_00450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHB5002_00470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthHB5002_00480	COG1335	isochorismatase
TthHB5002_00490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthHB5002_00520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthHB5002_00530	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthHB5002_00560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TthHB5002_00570	COG1660	Displays ATPase and GTPase activities
TthHB5002_00580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthHB5002_00640	COG1845	cytochrome c oxidase, subunit III
TthHB5002_00640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHB5002_00650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5002_00650	COG2010	Cytochrome c
TthHB5002_00660	COG0109	protoheme IX farnesyltransferase activity
TthHB5002_00660	COG1612	heme a metabolic process
TthHB5002_00690	COG0343	queuine tRNA-ribosyltransferase activity
TthHB5002_00700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthHB5002_00710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthHB5002_00760	COG1940	carbohydrate kinase activity
TthHB5002_00780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHB5002_00790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5002_00810	COG1611	Belongs to the LOG family
TthHB5002_00830	COG1011	Hydrolase
TthHB5002_00840	COG0632	four-way junction helicase activity
TthHB5002_00850	COG1024	Enoyl-CoA hydratase
TthHB5002_00870	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHB5002_00890	COG0137	argininosuccinate synthase activity
TthHB5002_00900	COG0165	Argininosuccinate lyase
TthHB5002_00940	COG0505	Belongs to the CarA family
TthHB5002_00960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthHB5002_00970	COG0166	Belongs to the GPI family
TthHB5002_00990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5002_01000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthHB5002_01010	COG0459	protein refolding
TthHB5002_01020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthHB5002_01030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthHB5002_01050	COG0778	Nitroreductase
TthHB5002_01060	COG0791	NLP P60 protein
TthHB5002_01060	COG1388	LysM domain
TthHB5002_01080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthHB5002_01100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthHB5002_01110	COG0581	inorganic phosphate transmembrane transporter activity
TthHB5002_01120	COG0573	inorganic phosphate transmembrane transporter activity
TthHB5002_01130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthHB5002_01140	COG0482	sulfurtransferase activity
TthHB5002_01160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthHB5002_01170	COG0735	belongs to the Fur family
TthHB5002_01200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthHB5002_01210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHB5002_01220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthHB5002_01230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthHB5002_01240	COG0250	Participates in transcription elongation, termination and antitermination
TthHB5002_01260	COG0081	regulation of translation
TthHB5002_01280	COG0629	single-stranded DNA binding
TthHB5002_01290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthHB5002_01300	COG0359	binds to the 23S rRNA
TthHB5002_01310	COG0300	oxidoreductase activity
TthHB5002_01340	COG0321	lipoyl(octanoyl) transferase activity
TthHB5002_01350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthHB5002_01410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthHB5002_01440	COG1598	PFAM Uncharacterised protein family UPF0150
TthHB5002_01450	COG0022	dehydrogenase e1 component
TthHB5002_01460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthHB5002_01470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthHB5002_01520	COG2226	methyltransferase
TthHB5002_01530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthHB5002_01550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthHB5002_01560	COG1187	pseudouridine synthase activity
TthHB5002_01600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthHB5002_01610	COG0686	Belongs to the AlaDH PNT family
TthHB5002_01630	COG1461	Dihydroxyacetone kinase
TthHB5002_01650	COG3584	3D domain protein
TthHB5002_01650	COG3583	domain protein
TthHB5002_01660	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthHB5002_01670	COG0222	ribosome binding
TthHB5002_01680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthHB5002_01710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthHB5002_01740	COG0697	spore germination
TthHB5002_01770	COG0243	molybdopterin cofactor binding
TthHB5002_01780	COG2272	Belongs to the type-B carboxylesterase lipase family
TthHB5002_01790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthHB5002_01810	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHB5002_01840	COG0477	Major facilitator Superfamily
TthHB5002_01870	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthHB5002_01890	COG0105	UTP biosynthetic process
TthHB5002_01900	COG0631	protein serine/threonine phosphatase activity
TthHB5002_01910	COG0583	DNA-binding transcription factor activity
TthHB5002_01930	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHB5002_02000	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthHB5002_02020	COG1278	Cold shock
TthHB5002_02030	COG0484	heat shock protein binding
TthHB5002_02040	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthHB5002_02050	COG1968	undecaprenyl-diphosphatase activity
TthHB5002_02060	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthHB5002_02070	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthHB5002_02100	COG1309	transcriptional regulator
TthHB5002_02110	COG4242	Belongs to the peptidase S51 family
TthHB5002_02140	COG0802	atpase or kinase
TthHB5002_02150	COG0539	negative regulation of cytoplasmic translation
TthHB5002_02160	COG0495	leucyl-tRNA aminoacylation
TthHB5002_02210	COG1902	pentaerythritol trinitrate reductase activity
TthHB5002_02260	COG2414	aldehyde ferredoxin oxidoreductase
TthHB5002_02290	COG2801	Transposase and inactivated derivatives
TthHB5002_02310	COG1187	pseudouridine synthase activity
TthHB5002_02330	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHB5002_02340	COG0745	RESPONSE REGULATOR receiver
TthHB5002_02350	COG4191	Histidine kinase
TthHB5002_02360	COG0704	Plays a role in the regulation of phosphate uptake
TthHB5002_02370	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthHB5002_02390	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthHB5002_02410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthHB5002_02410	COG0515	serine threonine protein kinase
TthHB5002_02450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthHB5002_02460	COG0300	oxidoreductase activity
TthHB5002_02490	COG0717	Belongs to the dCTP deaminase family
TthHB5002_02500	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthHB5002_02510	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthHB5002_02520	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5002_02540	COG0583	DNA-binding transcription factor activity
TthHB5002_02550	COG3546	catalase activity
TthHB5002_02560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHB5002_02560	COG0758	DNA mediated transformation
TthHB5002_02570	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthHB5002_02590	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5002_02610	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthHB5002_02620	COG0442	prolyl-tRNA aminoacylation
TthHB5002_02630	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthHB5002_02670	COG0303	'Molybdopterin
TthHB5002_02680	COG0513	Belongs to the DEAD box helicase family
TthHB5002_02690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthHB5002_02710	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthHB5002_02740	COG2070	2-Nitropropane dioxygenase
TthHB5002_02770	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthHB5002_02780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHB5002_02790	COG0018	arginyl-trna synthetase
TthHB5002_02800	COG1007	ATP synthesis coupled electron transport
TthHB5002_02810	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5002_02820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthHB5002_02830	COG0713	ATP synthesis coupled electron transport
TthHB5002_02840	COG0839	Belongs to the complex I subunit 6 family
TthHB5002_02850	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5002_02860	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthHB5002_02870	COG1034	ATP synthesis coupled electron transport
TthHB5002_02880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthHB5002_02890	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthHB5002_02900	COG0649	NAD binding
TthHB5002_02910	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5002_02920	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5002_02930	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5002_02940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthHB5002_02960	COG4712	double-strand break repair protein
TthHB5002_02990	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthHB5002_03020	COG0135	phosphoribosylanthranilate isomerase activity
TthHB5002_03030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHB5002_03030	COG1372	Participates in initiation and elongation during chromosome replication
TthHB5002_03040	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthHB5002_03060	COG2720	vancomycin resistance protein
TthHB5002_03070	COG1126	abc transporter atp-binding protein
TthHB5002_03130	COG0277	FAD linked oxidase domain protein
TthHB5002_03150	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthHB5002_03160	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthHB5002_03190	COG0314	molybdopterin synthase activity
TthHB5002_03200	COG1420	regulation of RNA biosynthetic process
TthHB5002_03210	COG0347	Belongs to the P(II) protein family
TthHB5002_03220	COG0004	ammonium transporteR
TthHB5002_03240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthHB5002_03270	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHB5002_03300	COG1597	lipid kinase activity
TthHB5002_03330	COG0436	Aminotransferase
TthHB5002_03350	COG0475	glutathione-regulated potassium exporter activity
TthHB5002_03350	COG0569	domain protein
TthHB5002_03370	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthHB5002_03390	COG0277	FAD linked oxidase domain protein
TthHB5002_03470	COG2801	Transposase and inactivated derivatives
TthHB5002_03520	COG2002	toxin-antitoxin pair type II binding
TthHB5002_03610	COG0667	Aldo Keto reductase
TthHB5002_03690	COG1067	ATP-dependent peptidase activity
TthHB5002_03700	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthHB5002_03720	COG0745	RESPONSE REGULATOR receiver
TthHB5002_03730	COG2105	PFAM AIG2 family protein
TthHB5002_03740	COG0297	glycogen (starch) synthase activity
TthHB5002_03760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthHB5002_03770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthHB5002_03800	COG0142	geranyltranstransferase activity
TthHB5002_03820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthHB5002_03830	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_03840	COG0492	ferredoxin-NADP+ reductase activity
TthHB5002_03860	COG0792	nuclease activity
TthHB5002_03870	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthHB5002_03900	COG1175	transmembrane transport
TthHB5002_03910	COG0395	ABC-type sugar transport system, permease component
TthHB5002_03980	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthHB5002_03990	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthHB5002_04000	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHB5002_04010	COG0805	protein transport
TthHB5002_04020	COG1605	Chorismate mutase
TthHB5002_04020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHB5002_04040	COG3573	Dehydrogenase
TthHB5002_04060	COG0346	lactoylglutathione lyase activity
TthHB5002_04140	COG1063	alcohol dehydrogenase
TthHB5002_04200	COG2255	four-way junction helicase activity
TthHB5002_04210	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthHB5002_04220	COG0564	pseudouridine synthase activity
TthHB5002_04250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthHB5002_04260	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthHB5002_04270	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthHB5002_04280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthHB5002_04300	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthHB5002_04310	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthHB5002_04320	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthHB5002_04390	COG0778	Nitroreductase
TthHB5002_04430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHB5002_04440	COG0131	Imidazoleglycerol-phosphate dehydratase
TthHB5002_04450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthHB5002_04460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthHB5002_04470	COG0517	IMP dehydrogenase activity
TthHB5002_04470	COG0516	GMP reductase activity
TthHB5002_04500	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthHB5002_04530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHB5002_04580	COG0706	membrane insertase activity
TthHB5002_04590	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthHB5002_04600	COG0594	ribonuclease P activity
TthHB5002_04630	COG1022	Amp-dependent synthetase and ligase
TthHB5002_04680	COG1121	(ABC) transporter
TthHB5002_04690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthHB5002_04700	COG1959	2 iron, 2 sulfur cluster binding
TthHB5002_04710	COG1104	cysteine desulfurase activity
TthHB5002_04720	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthHB5002_04730	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthHB5002_04760	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_04800	COG0492	ferredoxin-NADP+ reductase activity
TthHB5002_04810	COG3321	synthase
TthHB5002_04810	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_04810	COG0604	alcohol dehydrogenase
TthHB5002_04820	COG0747	negative chemotaxis
TthHB5002_04830	COG0601	transmembrane transport
TthHB5002_04840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5002_04870	COG0517	IMP dehydrogenase activity
TthHB5002_04880	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHB5002_04890	COG2104	thiamine diphosphate biosynthetic process
TthHB5002_04900	COG0037	tRNA processing
TthHB5002_04930	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthHB5002_04950	COG0366	Alpha amylase catalytic
TthHB5002_04960	COG2226	methyltransferase
TthHB5002_04970	COG2226	methyltransferase
TthHB5002_04980	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthHB5002_05000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthHB5002_05010	COG3744	PilT protein domain protein
TthHB5002_05030	COG0460	homoserine dehydrogenase
TthHB5002_05050	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthHB5002_05110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthHB5002_05150	COG0247	lactate metabolic process
TthHB5002_05160	COG0277	FAD linked oxidase domain protein
TthHB5002_05170	COG0277	FAD linked oxidase domain protein
TthHB5002_05180	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthHB5002_05190	COG1414	Transcriptional regulator
TthHB5002_05200	COG0789	Transcriptional regulator
TthHB5002_05220	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5002_05230	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHB5002_05300	COG0861	Integral membrane protein TerC family
TthHB5002_05310	COG2151	metal-sulfur cluster biosynthetic enzyme
TthHB5002_05320	COG0281	malic enzyme
TthHB5002_05350	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthHB5002_05360	COG0509	glycine decarboxylation via glycine cleavage system
TthHB5002_05370	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHB5002_05380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHB5002_05390	COG0196	riboflavin kinase activity
TthHB5002_05440	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthHB5002_05450	COG2813	Specifically methylates the guanine in position
TthHB5002_05460	COG0527	aspartate kinase activity
TthHB5002_05520	COG4956	integral membrane protein (PIN domain superfamily)
TthHB5002_05530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthHB5002_05540	COG0542	response to heat
TthHB5002_05550	COG0423	glycine-tRNA ligase activity
TthHB5002_05570	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthHB5002_05610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHB5002_05610	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5002_05630	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthHB5002_05650	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthHB5002_05670	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5002_05680	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHB5002_05690	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthHB5002_05700	COG0114	fumarate hydratase activity
TthHB5002_05710	COG0183	Belongs to the thiolase family
TthHB5002_05740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthHB5002_05750	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthHB5002_05780	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthHB5002_05790	COG1254	Belongs to the acylphosphatase family
TthHB5002_05820	COG1063	alcohol dehydrogenase
TthHB5002_05870	COG2133	pyrroloquinoline quinone binding
TthHB5002_05890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthHB5002_05900	COG0154	amidase activity
TthHB5002_05950	COG0572	uridine kinase
TthHB5002_05960	COG3842	ATPase activity
TthHB5002_05990	COG4475	Protein of unknown function (DUF436)
TthHB5002_06100	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHB5002_06110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthHB5002_06120	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthHB5002_06150	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthHB5002_06160	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthHB5002_06170	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthHB5002_06180	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthHB5002_06200	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5002_06230	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthHB5002_06240	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthHB5002_06250	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthHB5002_06270	COG3870	Protein conserved in bacteria
TthHB5002_06280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthHB5002_06300	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthHB5002_06310	COG0740	serine-type endopeptidase activity
TthHB5002_06320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthHB5002_06330	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthHB5002_06340	COG1410	methionine synthase
TthHB5002_06340	COG0646	methionine synthase
TthHB5002_06360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHB5002_06410	COG1692	metallophosphoesterase
TthHB5002_06420	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthHB5002_06430	COG1970	mechanosensitive ion channel activity
TthHB5002_06460	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHB5002_06480	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthHB5002_06490	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthHB5002_06650	COG0438	transferase activity, transferring glycosyl groups
TthHB5002_06690	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TthHB5002_06700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHB5002_06740	COG0489	protein tyrosine kinase activity
TthHB5002_06760	COG2264	protein methyltransferase activity
TthHB5002_06770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthHB5002_06830	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHB5002_06830	COG0574	Belongs to the PEP-utilizing enzyme family
TthHB5002_06850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthHB5002_06860	COG2046	Belongs to the sulfate adenylyltransferase family
TthHB5002_06870	COG1648	precorrin-2 dehydrogenase activity
TthHB5002_06870	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5002_06880	COG0730	response to heat
TthHB5002_06890	COG0175	sulfate reduction
TthHB5002_06900	COG1648	precorrin-2 dehydrogenase activity
TthHB5002_06900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5002_06910	COG1587	Uroporphyrinogen-III synthase
TthHB5002_06920	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthHB5002_06940	COG0352	thiamine-phosphate diphosphorylase activity
TthHB5002_06950	COG2104	thiamine diphosphate biosynthetic process
TthHB5002_06960	COG2022	thiamine diphosphate biosynthetic process
TthHB5002_06970	COG2022	thiamine diphosphate biosynthetic process
TthHB5002_06970	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5002_06980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthHB5002_06990	COG0477	Major facilitator Superfamily
TthHB5002_07000	COG0351	phosphomethylpyrimidine kinase
TthHB5002_07000	COG0352	thiamine-phosphate diphosphorylase activity
TthHB5002_07060	COG1175	transmembrane transport
TthHB5002_07080	COG1940	carbohydrate kinase activity
TthHB5002_07090	COG0183	Belongs to the thiolase family
TthHB5002_07140	COG2030	dehydratase
TthHB5002_07160	COG0596	Alpha beta hydrolase
TthHB5002_07170	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5002_07200	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHB5002_07200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHB5002_07220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthHB5002_07240	COG0195	Participates in both transcription termination and antitermination
TthHB5002_07250	COG0779	Required for maturation of 30S ribosomal subunits
TthHB5002_07260	COG0739	heme binding
TthHB5002_07270	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthHB5002_07280	COG0640	Transcriptional regulator
TthHB5002_07290	COG2217	Heavy metal translocating P-type atpase
TthHB5002_07300	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthHB5002_07310	COG0017	Asparaginyl-tRNA synthetase
TthHB5002_07320	COG0561	phosphatase activity
TthHB5002_07330	COG0384	phenazine biosynthesis protein PhzF
TthHB5002_07350	COG0124	histidyl-tRNA synthetase
TthHB5002_07370	COG3842	ATPase activity
TthHB5002_07400	COG1573	uracil-dna glycosylase
TthHB5002_07440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthHB5002_07450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHB5002_07450	COG0519	Catalyzes the synthesis of GMP from XMP
TthHB5002_07470	COG1316	TRANSCRIPTIONal
TthHB5002_07480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthHB5002_07580	COG0295	cytidine deaminase activity
TthHB5002_07600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHB5002_07620	COG1760	l-serine dehydratase
TthHB5002_07640	COG0481	GTPase activity
TthHB5002_07660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHB5002_07690	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_07740	COG0405	Gamma-glutamyltransferase
TthHB5002_07780	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthHB5002_07790	COG2873	o-acetylhomoserine
TthHB5002_07820	COG1063	alcohol dehydrogenase
TthHB5002_07840	COG3191	aminopeptidase activity
TthHB5002_07850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHB5002_07860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHB5002_07870	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthHB5002_07890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthHB5002_07910	COG0167	dihydroorotate dehydrogenase activity
TthHB5002_07940	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TthHB5002_07950	COG0540	Belongs to the ATCase OTCase family
TthHB5002_07960	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TthHB5002_07980	COG0730	response to heat
TthHB5002_07990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthHB5002_08010	COG1960	acyl-CoA dehydrogenase activity
TthHB5002_08020	COG0456	acetyltransferase
TthHB5002_08040	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthHB5002_08050	COG0009	L-threonylcarbamoyladenylate synthase
TthHB5002_08060	COG1459	type II secretion system
TthHB5002_08090	COG0277	FAD linked oxidase domain protein
TthHB5002_08130	COG0287	Prephenate dehydrogenase
TthHB5002_08140	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHB5002_08150	COG2514	catechol 2,3-dioxygenase activity
TthHB5002_08160	COG2353	YceI-like domain
TthHB5002_08170	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHB5002_08180	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHB5002_08220	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5002_08230	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthHB5002_08250	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthHB5002_08260	COG0151	Belongs to the GarS family
TthHB5002_08270	COG5002	protein histidine kinase activity
TthHB5002_08270	COG2176	DNA-directed DNA polymerase activity
TthHB5002_08330	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthHB5002_08350	COG0217	transcriptional regulatory protein
TthHB5002_08360	COG4651	solute:proton antiporter activity
TthHB5002_08360	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthHB5002_08370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthHB5002_08380	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthHB5002_08390	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHB5002_08400	COG1674	ftsk spoiiie
TthHB5002_08430	COG0517	IMP dehydrogenase activity
TthHB5002_08450	COG3620	sequence-specific DNA binding
TthHB5002_08450	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5002_08450	COG0617	tRNA 3'-terminal CCA addition
TthHB5002_08470	COG1994	Peptidase M50
TthHB5002_08480	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthHB5002_08500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHB5002_08530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHB5002_08540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHB5002_08550	COG2719	SpoVR family
TthHB5002_08560	COG2718	Belongs to the UPF0229 family
TthHB5002_08570	COG2766	serine protein kinase
TthHB5002_08620	COG2137	regulation of response to DNA damage stimulus
TthHB5002_08640	COG2359	stage V sporulation protein S
TthHB5002_08650	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHB5002_08660	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthHB5002_08680	COG0463	Glycosyl transferase, family 2
TthHB5002_08690	COG0750	zinc metalloprotease
TthHB5002_08700	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthHB5002_08710	COG4589	Belongs to the CDS family
TthHB5002_08720	COG0233	cytoplasmic translational termination
TthHB5002_08730	COG0528	UMP kinase activity
TthHB5002_08740	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthHB5002_08750	COG0052	Belongs to the universal ribosomal protein uS2 family
TthHB5002_08990	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthHB5002_09000	COG0494	nUDIX hydrolase
TthHB5002_09060	COG0402	S-adenosylhomocysteine deaminase activity
TthHB5002_09080	COG4948	Mandelate Racemase Muconate Lactonizing
TthHB5002_09090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthHB5002_09100	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5002_09110	COG1811	Na channel or pump
TthHB5002_09120	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5002_09120	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthHB5002_09150	COG1215	transferase activity, transferring glycosyl groups
TthHB5002_09170	COG1215	transferase activity, transferring glycosyl groups
TthHB5002_09190	COG0438	transferase activity, transferring glycosyl groups
TthHB5002_09200	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthHB5002_09250	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHB5002_09250	COG1024	Enoyl-CoA hydratase
TthHB5002_09260	COG0183	Belongs to the thiolase family
TthHB5002_09270	COG1960	acyl-CoA dehydrogenase activity
TthHB5002_09280	COG0215	cysteine-tRNA ligase activity
TthHB5002_09290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthHB5002_09310	COG2738	Putative neutral zinc metallopeptidase
TthHB5002_09340	COG1196	nuclear chromosome segregation
TthHB5002_09370	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthHB5002_09380	COG3153	acetyltransferase
TthHB5002_09380	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHB5002_09390	COG1268	BioY protein
TthHB5002_09410	COG0126	phosphoglycerate kinase activity
TthHB5002_09420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthHB5002_09430	COG0824	Thioesterase
TthHB5002_09450	COG0557	exoribonuclease II activity
TthHB5002_09460	COG1355	regulation of microtubule-based process
TthHB5002_09470	COG1353	crispr-associated protein
TthHB5002_09470	COG0617	tRNA 3'-terminal CCA addition
TthHB5002_09480	COG0237	dephospho-CoA kinase activity
TthHB5002_09500	COG0742	ribosomal rna small subunit methyltransferase
TthHB5002_09510	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthHB5002_09520	COG0138	bifunctional purine biosynthesis protein purh
TthHB5002_09530	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthHB5002_09560	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthHB5002_09670	COG0149	triose-phosphate isomerase activity
TthHB5002_09680	COG3239	Fatty acid desaturase
TthHB5002_09690	COG1490	D-aminoacyl-tRNA deacylase activity
TthHB5002_09700	COG1307	EDD domain protein, DegV family
TthHB5002_09710	COG1307	EDD domain protein, DegV family
TthHB5002_09720	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthHB5002_09730	COG1510	regulation of RNA biosynthetic process
TthHB5002_09750	COG3769	mannosylglycerate metabolic process
TthHB5002_09780	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5002_09790	COG2368	4-hydroxyphenylacetate
TthHB5002_09800	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthHB5002_09870	COG2050	protein possibly involved in aromatic compounds catabolism
TthHB5002_09880	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHB5002_09900	COG2030	dehydratase
TthHB5002_09900	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5002_09940	COG3396	Phenylacetate-CoA oxygenase
TthHB5002_09960	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthHB5002_10030	COG5297	Belongs to the glycosyl hydrolase family 6
TthHB5002_10030	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TthHB5002_10100	COG1192	Involved in chromosome partitioning
TthHB5002_10110	COG1475	DNA binding
TthHB5002_10130	COG1475	DNA binding
TthHB5002_10180	COG4966	pilus assembly protein PilW
TthHB5002_10230	COG3345	alpha-galactosidase
TthHB5002_10240	COG1085	galactose-1-phosphate uridylyltransferase
TthHB5002_10280	COG1304	FMN binding
TthHB5002_10300	COG1487	ribonuclease activity
TthHB5002_10350	COG2124	cytochrome p450
TthHB5002_10370	COG1562	ergosterol biosynthetic process
TthHB5002_10390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5002_10450	COG0702	epimerase
TthHB5002_10460	COG1233	COG1233 Phytoene dehydrogenase and related
TthHB5002_10500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHB5002_10510	COG2723	6-phospho-beta-galactosidase activity
TthHB5002_10530	COG1175	transmembrane transport
TthHB5002_10560	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_10590	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_10600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHB5002_10620	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthHB5002_10630	COG0800	Aldolase
TthHB5002_10650	COG1175	transmembrane transport
TthHB5002_10660	COG0395	ABC-type sugar transport system, permease component
TthHB5002_10710	COG1785	Belongs to the alkaline phosphatase family
TthHB5002_10720	COG1492	cobalamin metabolic process
TthHB5002_10740	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHB5002_10780	COG0778	Nitroreductase
TthHB5002_10790	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5002_10790	COG1648	precorrin-2 dehydrogenase activity
TthHB5002_10880	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthHB5002_10890	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthHB5002_10900	COG0588	phosphoglycerate mutase activity
TthHB5002_10930	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthHB5002_10960	COG1797	cobyrinic acid a,c-diamide synthase activity
TthHB5002_11030	COG2211	Major facilitator Superfamily
TthHB5002_11070	COG2211	Major facilitator Superfamily
TthHB5002_11130	COG2801	Transposase and inactivated derivatives
TthHB5002_11170	COG1337	RAMP superfamily
TthHB5002_11250	COG2801	Transposase and inactivated derivatives
TthHB5002_11300	COG1960	acyl-CoA dehydrogenase activity
TthHB5002_11320	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_11330	COG2030	dehydratase
TthHB5002_11330	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5002_11350	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5002_11360	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5002_11400	COG0588	phosphoglycerate mutase activity
TthHB5002_11670	COG2801	Transposase and inactivated derivatives
TthHB5002_11700	COG2329	Antibiotic biosynthesis monooxygenase
TthHB5002_11720	COG4558	Periplasmic binding protein
TthHB5002_11730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHB5002_11740	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthHB5002_11760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TthHB5002_11790	COG3706	GGDEF domain
TthHB5002_11930	COG0395	ABC-type sugar transport system, permease component
TthHB5002_11970	COG1980	fructose-bisphosphate aldolase activity
TthHB5002_11980	COG1733	regulation of RNA biosynthetic process
TthHB5002_11990	COG2193	ferroxidase activity
TthHB5002_12000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthHB5002_12010	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthHB5002_12030	COG1331	Highly conserved protein containing a thioredoxin domain
TthHB5002_12040	COG0183	Belongs to the thiolase family
TthHB5002_12050	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthHB5002_12120	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5002_12140	COG0248	Ppx GppA phosphatase
TthHB5002_12150	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthHB5002_12210	COG0745	RESPONSE REGULATOR receiver
TthHB5002_12220	COG2205	protein histidine kinase activity
TthHB5002_12260	COG1136	(ABC) transporter
TthHB5002_12270	COG1136	(ABC) transporter
TthHB5002_12270	COG0577	efflux transmembrane transporter activity
TthHB5002_12350	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5002_12400	COG0582	viral genome integration into host DNA
TthHB5002_12410	COG2897	thiosulfate sulfurtransferase activity
TthHB5002_12420	COG1760	l-serine dehydratase
TthHB5002_12430	COG2197	response regulator
TthHB5002_12440	COG0335	large ribosomal subunit rRNA binding
TthHB5002_12450	COG0336	Belongs to the RNA methyltransferase TrmD family
TthHB5002_12460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthHB5002_12470	COG1837	Belongs to the UPF0109 family
TthHB5002_12480	COG0228	four-way junction DNA binding
TthHB5002_12510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5002_12520	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5002_12520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5002_12530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthHB5002_12550	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthHB5002_12570	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthHB5002_12580	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthHB5002_12590	COG1702	phosphate starvation-inducible protein PhoH
TthHB5002_12610	COG4864	UPF0365 protein
TthHB5002_12630	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthHB5002_12670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5002_12670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5002_12690	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHB5002_12710	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthHB5002_12720	COG1397	ADP-ribosylglycohydrolase
TthHB5002_12730	COG2239	Acts as a magnesium transporter
TthHB5002_12750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHB5002_12750	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHB5002_12770	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHB5002_12770	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHB5002_12780	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthHB5002_12790	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthHB5002_12800	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthHB5002_12810	COG0006	proline dipeptidase activity
TthHB5002_12830	COG0739	heme binding
TthHB5002_12850	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthHB5002_12860	COG0254	rRNA binding
TthHB5002_12880	COG2001	Belongs to the MraZ family
TthHB5002_12890	COG0275	rRNA processing
TthHB5002_12910	COG0768	penicillin binding
TthHB5002_12920	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthHB5002_12940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHB5002_12950	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthHB5002_12960	COG0772	Belongs to the SEDS family
TthHB5002_12970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthHB5002_12980	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthHB5002_12990	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthHB5002_13030	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthHB5002_13050	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHB5002_13070	COG0159	tryptophan synthase activity
TthHB5002_13080	COG0133	tryptophan synthase activity
TthHB5002_13090	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthHB5002_13100	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHB5002_13110	COG1744	ABC transporter substrate-binding protein PnrA-like
TthHB5002_13120	COG3845	ABC transporter
TthHB5002_13220	COG0438	transferase activity, transferring glycosyl groups
TthHB5002_13230	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHB5002_13250	COG0039	L-malate dehydrogenase activity
TthHB5002_13260	COG2819	hydrolase of the alpha beta superfamily
TthHB5002_13270	COG0861	Integral membrane protein TerC family
TthHB5002_13290	COG0247	lactate metabolic process
TthHB5002_13290	COG2181	nitrate reductase activity
TthHB5002_13310	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthHB5002_13320	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthHB5002_13330	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthHB5002_13350	COG0439	Biotin carboxylase
TthHB5002_13360	COG0511	ligase activity, forming carbon-carbon bonds
TthHB5002_13370	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthHB5002_13410	COG0010	Belongs to the arginase family
TthHB5002_13440	COG1100	Small GTP-binding protein
TthHB5002_13460	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5002_13470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHB5002_13500	COG2814	Major facilitator Superfamily
TthHB5002_13520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthHB5002_13530	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHB5002_13540	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthHB5002_13560	COG0745	RESPONSE REGULATOR receiver
TthHB5002_13570	COG5002	protein histidine kinase activity
TthHB5002_13580	COG1960	acyl-CoA dehydrogenase activity
TthHB5002_13590	COG2086	electron transfer activity
TthHB5002_13600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthHB5002_13620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHB5002_13630	COG1573	uracil-dna glycosylase
TthHB5002_13640	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHB5002_13640	COG1796	DNA polymerase
TthHB5002_13670	COG2309	aminopeptidase activity
TthHB5002_13710	COG2873	o-acetylhomoserine
TthHB5002_13720	COG2358	TRAP transporter, solute receptor (TAXI family
TthHB5002_13740	COG1126	abc transporter atp-binding protein
TthHB5002_13760	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHB5002_13770	COG0134	indole-3-glycerol-phosphate synthase activity
TthHB5002_13780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthHB5002_13800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthHB5002_13830	COG0765	amino acid transport
TthHB5002_13840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthHB5002_13860	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthHB5002_13870	COG0569	domain protein
TthHB5002_13880	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5002_13900	COG2313	pseudouridylate synthase activity
TthHB5002_13920	COG3001	Fructosamine kinase
TthHB5002_13930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHB5002_13950	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthHB5002_13980	COG0012	GTP binding
TthHB5002_13990	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthHB5002_14010	COG0424	maF-like protein
TthHB5002_14040	COG0768	penicillin binding
TthHB5002_14060	COG2322	membrane
TthHB5002_14100	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthHB5002_14110	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHB5002_14130	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthHB5002_14160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5002_14180	COG2801	Transposase and inactivated derivatives
TthHB5002_14240	COG1131	(ABC) transporter
TthHB5002_14270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHB5002_14300	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthHB5002_14310	COG0440	acetolactate synthase activity
TthHB5002_14320	COG0028	Belongs to the TPP enzyme family
TthHB5002_14330	COG0492	ferredoxin-NADP+ reductase activity
TthHB5002_14340	COG4970	Tfp pilus assembly protein FimT
TthHB5002_14390	COG2165	general secretion pathway protein
TthHB5002_14450	COG0180	Tryptophanyl-tRNA synthetase
TthHB5002_14460	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHB5002_14470	COG0066	3-isopropylmalate dehydratase activity
TthHB5002_14480	COG0473	3-isopropylmalate dehydrogenase activity
TthHB5002_14510	COG0300	oxidoreductase activity
TthHB5002_14520	COG0129	dihydroxy-acid dehydratase activity
TthHB5002_14540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthHB5002_14550	COG1177	transmembrane transport
TthHB5002_14560	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthHB5002_14570	COG3842	ATPase activity
TthHB5002_14580	COG0772	Belongs to the SEDS family
TthHB5002_14590	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthHB5002_14600	COG2894	cell division
TthHB5002_14610	COG1733	regulation of RNA biosynthetic process
TthHB5002_14630	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5002_14630	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5002_14650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5002_14660	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5002_14670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5002_14680	COG0653	protein targeting
TthHB5002_14690	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthHB5002_14730	COG0393	Putative heavy-metal-binding
TthHB5002_14740	COG1111	helicase
TthHB5002_14740	COG1205	dead DEAH box helicase
TthHB5002_14770	COG0358	DNA primase activity
TthHB5002_14790	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHB5002_14800	COG0612	Peptidase, M16
TthHB5002_14810	COG0612	Peptidase, M16
TthHB5002_14820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthHB5002_14850	COG1394	ATPase activity, coupled to movement of substances
TthHB5002_14860	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthHB5002_14870	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthHB5002_14880	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHB5002_14890	COG1527	subunit (C
TthHB5002_14900	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHB5002_14920	COG1269	ATP hydrolysis coupled proton transport
TthHB5002_14970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHB5002_14990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5002_15020	COG0419	ATPase involved in DNA repair
TthHB5002_15030	COG0420	3'-5' exonuclease activity
TthHB5002_15070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthHB5002_15080	COG2884	Cell division ATP-binding protein ftsE
TthHB5002_15090	COG0793	Belongs to the peptidase S41A family
TthHB5002_15110	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5002_15110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5002_15120	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthHB5002_15130	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthHB5002_15150	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHB5002_15160	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHB5002_15170	COG1129	ABC transporter
TthHB5002_15180	COG0746	molybdenum cofactor guanylyltransferase activity
TthHB5002_15200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5002_15240	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthHB5002_15250	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHB5002_15260	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthHB5002_15280	COG1994	Peptidase M50
TthHB5002_15280	COG0517	IMP dehydrogenase activity
TthHB5002_15290	COG2358	TRAP transporter, solute receptor (TAXI family
TthHB5002_15330	COG0788	formyltetrahydrofolate deformylase activity
TthHB5002_15340	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthHB5002_15350	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthHB5002_15360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthHB5002_15400	COG0737	Belongs to the 5'-nucleotidase family
TthHB5002_15410	COG0174	glutamine synthetase
TthHB5002_15430	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHB5002_15470	COG0747	negative chemotaxis
TthHB5002_15480	COG0601	transmembrane transport
TthHB5002_15490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5002_15510	COG0285	dihydrofolate synthase activity
TthHB5002_15520	COG1132	(ABC) transporter
TthHB5002_15530	COG1132	(ABC) transporter
TthHB5002_15540	COG0372	Belongs to the citrate synthase family
TthHB5002_15550	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthHB5002_15560	COG1482	cell wall glycoprotein biosynthetic process
TthHB5002_15580	COG1515	deoxyribonuclease V activity
TthHB5002_15600	COG0776	regulation of translation
TthHB5002_15630	COG2197	response regulator
TthHB5002_15640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthHB5002_15650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthHB5002_15660	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthHB5002_15670	COG1324	tolerance protein
TthHB5002_15700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5002_15740	COG2205	protein histidine kinase activity
TthHB5002_15760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthHB5002_15780	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthHB5002_15810	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TthHB5002_15820	COG0247	lactate metabolic process
TthHB5002_15830	COG1139	Iron-sulfur cluster binding protein
TthHB5002_15840	COG1556	Lactate utilization protein
TthHB5002_15860	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHB5002_15870	COG0515	serine threonine protein kinase
TthHB5002_15870	COG2815	serine threonine protein kinase
TthHB5002_15890	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthHB5002_15910	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthHB5002_15960	COG0473	3-isopropylmalate dehydrogenase activity
TthHB5002_16010	COG1450	Type ii and iii secretion system protein
TthHB5002_16020	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthHB5002_16030	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthHB5002_16040	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthHB5002_16050	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHB5002_16050	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthHB5002_16060	COG0736	holo-[acyl-carrier-protein] synthase activity
TthHB5002_16090	COG1160	GTP binding
TthHB5002_16100	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthHB5002_16110	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthHB5002_16110	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthHB5002_16120	COG0083	homoserine kinase activity
TthHB5002_16140	COG0268	Binds directly to 16S ribosomal RNA
TthHB5002_16160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthHB5002_16170	COG0723	plastoquinol--plastocyanin reductase activity
TthHB5002_16190	COG4235	cytochrome complex assembly
TthHB5002_16190	COG3088	subunit of a heme lyase
TthHB5002_16200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHB5002_16210	COG1138	Cytochrome C-type biogenesis protein
TthHB5002_16220	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthHB5002_16230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHB5002_16240	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHB5002_16250	COG4133	protoheme IX ABC transporter activity
TthHB5002_16260	COG0785	Cytochrome C biogenesis protein
TthHB5002_16270	COG3258	Cytochrome c
TthHB5002_16290	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHB5002_16320	COG3258	Cytochrome c
TthHB5002_16330	COG2010	Cytochrome c
TthHB5002_16340	COG0737	Belongs to the 5'-nucleotidase family
TthHB5002_16350	COG2010	Cytochrome c
TthHB5002_16360	COG3258	Cytochrome c
TthHB5002_16400	COG2010	Cytochrome c
TthHB5002_16410	COG3842	ATPase activity
TthHB5002_16470	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5002_16470	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5002_16480	COG3360	Dodecin
TthHB5002_16510	COG1024	Enoyl-CoA hydratase
TthHB5002_16520	COG0813	purine-nucleoside phosphorylase activity
TthHB5002_16530	COG1136	(ABC) transporter
TthHB5002_16540	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5002_16550	COG2045	Belongs to the ComB family
TthHB5002_16570	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthHB5002_16590	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthHB5002_16610	COG0107	imidazoleglycerol-phosphate synthase activity
TthHB5002_16620	COG0140	phosphoribosyl-ATP diphosphatase activity
TthHB5002_16620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthHB5002_16640	COG1494	fructose-1,6-bisphosphatase
TthHB5002_16650	COG0686	Belongs to the AlaDH PNT family
TthHB5002_16660	COG0427	acetyl-CoA hydrolase
TthHB5002_16670	COG0084	hydrolase, TatD family'
TthHB5002_16680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthHB5002_16700	COG0017	Asparaginyl-tRNA synthetase
TthHB5002_16720	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthHB5002_16750	COG2009	succinate dehydrogenase
TthHB5002_16760	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHB5002_16820	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5002_16830	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthHB5002_16840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthHB5002_16850	COG0504	CTP synthase activity
TthHB5002_16870	COG0069	glutamate synthase activity
TthHB5002_16870	COG0067	glutamate synthase
TthHB5002_16870	COG0070	glutamate synthase
TthHB5002_16890	COG0840	transmembrane signaling receptor activity
TthHB5002_16900	COG0305	Participates in initiation and elongation during chromosome replication
TthHB5002_16920	COG0475	glutathione-regulated potassium exporter activity
TthHB5002_16930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5002_16930	COG0617	tRNA 3'-terminal CCA addition
TthHB5002_16930	COG0517	IMP dehydrogenase activity
TthHB5002_16960	COG0475	glutathione-regulated potassium exporter activity
TthHB5002_16970	COG0490	domain, Protein
TthHB5002_17010	COG3118	belongs to the thioredoxin family
TthHB5002_17070	COG0542	response to heat
TthHB5002_17100	COG0789	Transcriptional regulator
TthHB5002_17110	COG0484	heat shock protein binding
TthHB5002_17120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthHB5002_17130	COG0443	Heat shock 70 kDa protein
TthHB5002_17140	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthHB5002_17150	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthHB5002_17160	COG0616	signal peptide processing
TthHB5002_17190	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthHB5002_17200	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthHB5002_17210	COG0714	Associated with various cellular activities
TthHB5002_17220	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHB5002_17220	COG0574	Belongs to the PEP-utilizing enzyme family
TthHB5002_17230	COG1272	protein, Hemolysin III
TthHB5002_17250	COG5002	protein histidine kinase activity
TthHB5002_17250	COG3850	Histidine kinase
TthHB5002_17280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthHB5002_17310	COG1011	Hydrolase
TthHB5002_17350	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthHB5002_17370	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthHB5002_17390	COG0047	phosphoribosylformylglycinamidine synthase activity
TthHB5002_17410	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthHB5002_17420	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthHB5002_17430	COG0116	Belongs to the methyltransferase superfamily
TthHB5002_17460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthHB5002_17470	COG0497	DNA recombination
TthHB5002_17490	COG0604	alcohol dehydrogenase
TthHB5002_17530	COG0585	pseudouridine synthase activity
TthHB5002_17560	COG0557	exoribonuclease II activity
TthHB5002_17570	COG0538	isocitrate dehydrogenase activity
TthHB5002_17580	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5002_17710	COG0590	tRNA wobble adenosine to inosine editing
TthHB5002_17710	COG0037	tRNA processing
TthHB5002_17750	COG2050	protein possibly involved in aromatic compounds catabolism
TthHB5002_17770	COG0322	excinuclease ABC activity
TthHB5002_17780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHB5002_17790	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHB5002_17800	COG1854	S-ribosylhomocysteine lyase activity
TthHB5002_17810	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHB5002_17810	COG0519	Catalyzes the synthesis of GMP from XMP
TthHB5002_17830	COG4274	PFAM GYD family protein
TthHB5002_17840	COG0346	lactoylglutathione lyase activity
TthHB5002_17850	COG0328	RNA-DNA hybrid ribonuclease activity
TthHB5002_17860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHB5002_17870	COG2095	MarC family integral membrane protein
TthHB5002_17880	COG1438	arginine binding
TthHB5002_17890	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthHB5002_17900	COG1758	RNA polymerase activity
TthHB5002_17910	COG0194	GDP metabolic process
TthHB5002_17930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthHB5002_17940	COG2385	sporulation resulting in formation of a cellular spore
TthHB5002_17950	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthHB5002_17970	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHB5002_18050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHB5002_18060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHB5002_18070	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5002_18080	COG0506	proline dehydrogenase activity
TthHB5002_18110	COG0156	8-amino-7-oxononanoate synthase activity
TthHB5002_18120	COG0732	type I restriction modification DNA specificity domain
TthHB5002_18120	COG0827	DNA restriction-modification system
TthHB5002_18170	COG0187	DNA topoisomerase II activity
TthHB5002_18180	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthHB5002_18190	COG0193	aminoacyl-tRNA hydrolase activity
TthHB5002_18200	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthHB5002_18250	COG0515	serine threonine protein kinase
TthHB5002_18250	COG2815	serine threonine protein kinase
TthHB5002_18260	COG0631	protein serine/threonine phosphatase activity
TthHB5002_18280	COG2814	Major facilitator Superfamily
TthHB5002_18290	COG0113	porphobilinogen synthase activity
TthHB5002_18300	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthHB5002_18310	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthHB5002_18360	COG4946	Tricorn protease homolog
TthHB5002_18360	COG1506	peptidase
TthHB5002_18360	COG0823	Involved in the tonB-independent uptake of proteins
TthHB5002_18370	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthHB5002_18380	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthHB5002_18420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthHB5002_18430	COG1011	Hydrolase
TthHB5002_18480	COG0537	adenosine 5'-monophosphoramidase activity
TthHB5002_18490	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5002_18500	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthHB5002_18510	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthHB5002_18520	COG0071	Belongs to the small heat shock protein (HSP20) family
TthHB5002_18530	COG2897	thiosulfate sulfurtransferase activity
TthHB5002_18540	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHB5002_18560	COG1764	response to oxidative stress
TthHB5002_18610	COG3842	ATPase activity
TthHB5002_18620	COG0101	tRNA pseudouridine synthase activity
TthHB5002_18630	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5002_18650	COG0006	proline dipeptidase activity
TthHB5002_18660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHB5002_18690	COG1166	arginine decarboxylase activity
TthHB5002_18710	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthHB5002_18720	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthHB5002_18730	COG1611	Belongs to the LOG family
TthHB5002_18740	COG1193	negative regulation of DNA recombination
TthHB5002_18760	COG0366	Alpha amylase catalytic
TthHB5002_18830	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthHB5002_18840	COG0142	geranyltranstransferase activity
TthHB5002_18870	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthHB5002_18930	COG0203	ribosomal protein L17
TthHB5002_18940	COG0202	RNA polymerase activity
TthHB5002_18950	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthHB5002_18960	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthHB5002_18970	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthHB5002_18980	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthHB5002_19000	COG0563	adenylate kinase activity
TthHB5002_19010	COG0201	protein transport
TthHB5002_19060	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthHB5002_19070	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthHB5002_19080	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthHB5002_19120	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TthHB5002_19130	COG0255	Belongs to the universal ribosomal protein uL29 family
TthHB5002_19140	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthHB5002_19150	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthHB5002_19170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthHB5002_19180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthHB5002_19190	COG0089	rRNA binding
TthHB5002_19200	COG0088	Forms part of the polypeptide exit tunnel
TthHB5002_19220	COG0051	transcription antitermination factor activity, RNA binding
TthHB5002_19230	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHB5002_19250	COG0049	tRNA binding
TthHB5002_19280	COG0442	prolyl-tRNA aminoacylation
TthHB5002_19320	COG1115	amino acid carrier protein
TthHB5002_19360	COG1489	DNA binding
TthHB5002_19410	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthHB5002_19450	COG0432	Pfam Uncharacterised protein family UPF0047
TthHB5002_19460	COG3253	May function as heme-dependent peroxidase
TthHB5002_19470	COG0668	transmembrane transport
TthHB5002_19490	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthHB5002_19500	COG2217	Heavy metal translocating P-type atpase
TthHB5002_19540	COG0745	RESPONSE REGULATOR receiver
TthHB5002_19550	COG2205	protein histidine kinase activity
TthHB5002_19590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHB5002_19600	COG2226	methyltransferase
TthHB5002_19660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthHB5002_19670	COG0822	iron-sulfur transferase activity
TthHB5002_19710	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthHB5002_19730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthHB5002_19740	COG0284	orotidine-5'-phosphate decarboxylase activity
TthHB5002_19760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthHB5002_19780	COG0416	fatty acid biosynthetic process
TthHB5002_19790	COG3118	belongs to the thioredoxin family
TthHB5002_19800	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHB5002_19810	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthHB5002_19830	COG0438	transferase activity, transferring glycosyl groups
TthHB5002_19880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthHB5002_19910	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHB5002_19920	COG3706	GGDEF domain
TthHB5002_19980	COG0437	4 iron, 4 sulfur cluster binding
TthHB5002_20020	COG0825	malonyl-CoA metabolic process
TthHB5002_20030	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthHB5002_20100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthHB5002_20150	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthHB5002_20160	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthHB5002_20170	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthHB5002_20180	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthHB5002_20240	COG0315	cyclic pyranopterin monophosphate synthase activity
TthHB5002_20260	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthHB5002_20290	COG1694	Mazg nucleotide pyrophosphohydrolase
TthHB5002_20300	COG1803	Methylglyoxal synthase
TthHB5002_20320	COG0301	tRNA thio-modification
TthHB5002_20330	COG0154	amidase activity
TthHB5002_20340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthHB5002_20370	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthHB5002_20380	COG1607	acyl-coa hydrolase
TthHB5002_20400	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthHB5002_20410	COG4149	molybdate abc transporter
TthHB5002_20420	COG1840	ABC-type Fe3 transport system, periplasmic component
TthHB5002_20450	COG0235	Class ii aldolase
TthHB5002_20460	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthHB5002_20470	COG0085	RNA polymerase activity
TthHB5002_20490	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthHB5002_20500	COG1077	Cell shape determining protein MreB Mrl
TthHB5002_20510	COG1418	mRNA catabolic process
TthHB5002_20510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthHB5002_20520	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthHB5002_20530	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthHB5002_20540	COG1058	Belongs to the CinA family
TthHB5002_20540	COG1546	Belongs to the CinA family
TthHB5002_20550	COG0354	folic acid binding
TthHB5002_20580	COG4948	Mandelate Racemase Muconate Lactonizing
TthHB5002_20610	COG1175	transmembrane transport
TthHB5002_20630	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthHB5002_20650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHB5002_20670	COG1136	(ABC) transporter
TthHB5002_20670	COG0577	efflux transmembrane transporter activity
TthHB5002_20680	COG4181	ATPase activity
TthHB5002_20690	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHB5002_20720	COG0396	ATPase activity
TthHB5002_20730	COG0719	Fe-S assembly protein
TthHB5002_20740	COG0719	Fe-S assembly protein
TthHB5002_20750	COG2146	nitrite reductase [NAD(P)H] activity
TthHB5002_20770	COG0512	Glutamine amidotransferase of anthranilate synthase
TthHB5002_20780	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHB5002_20860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHB5002_20870	COG2226	methyltransferase
TthHB5002_20880	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHB5002_20890	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHB5002_20920	COG1774	PSP1 C-terminal conserved region
TthHB5002_20930	COG0470	DNA polymerase III
TthHB5002_21000	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthHB5002_21010	COG0302	gtp cyclohydrolase
TthHB5002_21050	COG1217	gtp-binding protein TYPA
TthHB5002_21070	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthHB5002_21090	COG0395	ABC-type sugar transport system, permease component
TthHB5002_21100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthHB5002_21110	COG1131	(ABC) transporter
TthHB5002_21150	COG0556	nucleotide-excision repair
TthHB5002_21160	COG0497	DNA recombination
TthHB5002_21170	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHB5002_21180	COG0445	tRNA wobble uridine modification
TthHB5002_21220	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthHB5002_21230	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthHB5002_21230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHB5002_21240	COG1543	Belongs to the glycosyl hydrolase 57 family
TthHB5002_21250	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHB5002_21260	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHB5002_21290	COG0189	ligase activity
TthHB5002_21320	COG0066	3-isopropylmalate dehydratase activity
TthHB5002_21330	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHB5002_21340	COG1598	PFAM Uncharacterised protein family UPF0150
TthHB5002_21360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHB5002_21370	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthHB5002_21380	COG1960	acyl-CoA dehydrogenase activity
TthHB5002_21390	COG0163	prenyltransferase activity
TthHB5002_21440	COG1668	transmembrane transport
TthHB5002_21450	COG4555	ABC transporter
TthHB5002_21470	COG2096	Adenosyltransferase
TthHB5002_21500	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthHB5002_21510	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthHB5002_21540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthHB5002_21550	COG0723	plastoquinol--plastocyanin reductase activity
TthHB5002_21570	COG2010	Cytochrome c
TthHB5002_21620	COG1653	transport
TthHB5002_21630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthHB5002_21640	COG1960	acyl-CoA dehydrogenase activity
TthHB5002_21660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthHB5002_21700	COG0393	Putative heavy-metal-binding
TthHB5002_21720	COG3956	TIGRFAM MazG family protein
TthHB5002_21740	COG0693	protein deglycase activity
TthHB5002_21750	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHB5002_21770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthHB5002_21780	COG1937	Protein conserved in bacteria
TthHB5002_21800	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthHB5002_21800	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthHB5002_21810	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthHB5002_21820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5002_21860	COG0205	6-phosphofructokinase activity
TthHB5002_21870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthHB5002_21890	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthHB5002_21920	COG0658	competence protein
TthHB5002_21920	COG2333	competence protein COMEC
TthHB5002_21930	COG1475	DNA binding
TthHB5002_21940	COG1192	Involved in chromosome partitioning
TthHB5002_21950	COG0357	Ribosomal RNA small subunit methyltransferase G
TthHB5002_21960	COG0445	tRNA wobble uridine modification
TthHB5002_b22010	COG1175	transmembrane transport
TthHB5002_b22050	COG3454	Phosphonate metabolism
TthHB5002_b22060	COG4778	phosphonate C-P lyase system protein PhnL
TthHB5002_b22080	COG3627	carbon phosphorus lyase activity
TthHB5002_b22120	COG3639	organic phosphonate transmembrane transporter activity
TthHB5002_b22140	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthHB5002_b22260	COG1475	DNA binding
TthHB5002_b22270	COG1192	Involved in chromosome partitioning
TthHB5002_b22320	COG4213	ABC transporter substrate-binding protein
TthHB5002_b22330	COG4214	carbohydrate transport
TthHB5002_b22340	COG1129	ABC transporter
TthHB5002_b22350	COG1940	carbohydrate kinase activity
TthHB5002_b22370	COG1070	Carbohydrate kinase
TthHB5002_b22390	COG0673	inositol 2-dehydrogenase activity
TthHB5002_b22400	COG0300	oxidoreductase activity
TthHB5002_b22440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthHB5002_b22520	COG2002	toxin-antitoxin pair type II binding
TthHB5002_b22880	COG1074	ATP-dependent DNA helicase activity
TthHB5002_b22910	COG1203	CRISPR-associated helicase, Cas3
TthHB5002_b23050	COG0395	ABC-type sugar transport system, permease component
TthHB5002_b23060	COG1175	transmembrane transport
TthHB5002_b23090	COG1692	metallophosphoesterase
TthHB5002_c23140	COG1192	Involved in chromosome partitioning
TthHB5002_d23250	COG2801	Transposase and inactivated derivatives
TthHB5002_t00360	COG0544	peptidyl-prolyl cis-trans isomerase activity