locus-tag	class	description
TthHB5008_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthHB5008_00020	COG0592	DNA-directed DNA polymerase activity
TthHB5008_00030	COG0148	phosphopyruvate hydratase activity
TthHB5008_00040	COG0469	pyruvate kinase activity
TthHB5008_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHB5008_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthHB5008_00090	COG1842	Phage shock protein A
TthHB5008_00100	COG0406	alpha-ribazole phosphatase activity
TthHB5008_00110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthHB5008_00120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5008_00140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthHB5008_00150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthHB5008_00160	COG1496	oxidoreductase activity
TthHB5008_00170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthHB5008_00180	COG1278	Cold shock
TthHB5008_00190	COG1653	transport
TthHB5008_00220	COG0033	Phosphoglucomutase
TthHB5008_00270	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthHB5008_00270	COG0517	IMP dehydrogenase activity
TthHB5008_00280	COG1950	PFAM Membrane protein of
TthHB5008_00290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthHB5008_00310	COG0181	hydroxymethylbilane synthase activity
TthHB5008_00330	COG0285	dihydrofolate synthase activity
TthHB5008_00340	COG0436	Aminotransferase
TthHB5008_00350	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthHB5008_00400	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthHB5008_00410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthHB5008_00420	COG1993	acr, cog1993
TthHB5008_00430	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthHB5008_00450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHB5008_00470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthHB5008_00480	COG1335	isochorismatase
TthHB5008_00490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthHB5008_00520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthHB5008_00530	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthHB5008_00560	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TthHB5008_00570	COG1660	Displays ATPase and GTPase activities
TthHB5008_00580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthHB5008_00640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHB5008_00640	COG1845	cytochrome c oxidase, subunit III
TthHB5008_00650	COG2010	Cytochrome c
TthHB5008_00650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5008_00660	COG0109	protoheme IX farnesyltransferase activity
TthHB5008_00660	COG1612	heme a metabolic process
TthHB5008_00690	COG0343	queuine tRNA-ribosyltransferase activity
TthHB5008_00700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthHB5008_00710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthHB5008_00760	COG1940	carbohydrate kinase activity
TthHB5008_00780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHB5008_00790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5008_00810	COG1611	Belongs to the LOG family
TthHB5008_00830	COG1011	Hydrolase
TthHB5008_00840	COG0632	four-way junction helicase activity
TthHB5008_00850	COG1024	Enoyl-CoA hydratase
TthHB5008_00870	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHB5008_00890	COG0137	argininosuccinate synthase activity
TthHB5008_00900	COG0165	Argininosuccinate lyase
TthHB5008_00940	COG0505	Belongs to the CarA family
TthHB5008_00960	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthHB5008_00970	COG0166	Belongs to the GPI family
TthHB5008_00990	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5008_01000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthHB5008_01010	COG0459	protein refolding
TthHB5008_01020	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthHB5008_01030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthHB5008_01050	COG0778	Nitroreductase
TthHB5008_01060	COG0791	NLP P60 protein
TthHB5008_01060	COG1388	LysM domain
TthHB5008_01080	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthHB5008_01100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthHB5008_01110	COG0581	inorganic phosphate transmembrane transporter activity
TthHB5008_01120	COG0573	inorganic phosphate transmembrane transporter activity
TthHB5008_01130	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthHB5008_01140	COG0482	sulfurtransferase activity
TthHB5008_01160	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthHB5008_01170	COG0735	belongs to the Fur family
TthHB5008_01200	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthHB5008_01210	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHB5008_01220	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthHB5008_01230	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthHB5008_01240	COG0250	Participates in transcription elongation, termination and antitermination
TthHB5008_01260	COG0081	regulation of translation
TthHB5008_01280	COG0629	single-stranded DNA binding
TthHB5008_01290	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthHB5008_01300	COG0359	binds to the 23S rRNA
TthHB5008_01310	COG0300	oxidoreductase activity
TthHB5008_01340	COG0321	lipoyl(octanoyl) transferase activity
TthHB5008_01350	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthHB5008_01410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthHB5008_01440	COG1598	PFAM Uncharacterised protein family UPF0150
TthHB5008_01450	COG0022	dehydrogenase e1 component
TthHB5008_01460	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthHB5008_01470	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthHB5008_01520	COG2226	methyltransferase
TthHB5008_01530	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthHB5008_01550	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthHB5008_01560	COG1187	pseudouridine synthase activity
TthHB5008_01600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthHB5008_01610	COG0686	Belongs to the AlaDH PNT family
TthHB5008_01630	COG1461	Dihydroxyacetone kinase
TthHB5008_01650	COG3583	domain protein
TthHB5008_01650	COG3584	3D domain protein
TthHB5008_01660	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthHB5008_01670	COG0222	ribosome binding
TthHB5008_01680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthHB5008_01700	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthHB5008_01730	COG0697	spore germination
TthHB5008_01760	COG0243	molybdopterin cofactor binding
TthHB5008_01770	COG2272	Belongs to the type-B carboxylesterase lipase family
TthHB5008_01780	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthHB5008_01800	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHB5008_01830	COG0477	Major facilitator Superfamily
TthHB5008_01860	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthHB5008_01880	COG0105	UTP biosynthetic process
TthHB5008_01890	COG0631	protein serine/threonine phosphatase activity
TthHB5008_01900	COG0583	DNA-binding transcription factor activity
TthHB5008_01920	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHB5008_01990	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthHB5008_02010	COG1278	Cold shock
TthHB5008_02020	COG0484	heat shock protein binding
TthHB5008_02030	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthHB5008_02040	COG1968	undecaprenyl-diphosphatase activity
TthHB5008_02050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthHB5008_02060	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthHB5008_02090	COG1309	transcriptional regulator
TthHB5008_02100	COG4242	Belongs to the peptidase S51 family
TthHB5008_02130	COG0802	atpase or kinase
TthHB5008_02140	COG0539	negative regulation of cytoplasmic translation
TthHB5008_02150	COG0495	leucyl-tRNA aminoacylation
TthHB5008_02200	COG1902	pentaerythritol trinitrate reductase activity
TthHB5008_02250	COG2414	aldehyde ferredoxin oxidoreductase
TthHB5008_02280	COG2801	Transposase and inactivated derivatives
TthHB5008_02300	COG1187	pseudouridine synthase activity
TthHB5008_02320	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHB5008_02330	COG0745	RESPONSE REGULATOR receiver
TthHB5008_02340	COG4191	Histidine kinase
TthHB5008_02350	COG0704	Plays a role in the regulation of phosphate uptake
TthHB5008_02360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthHB5008_02380	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthHB5008_02400	COG0515	serine threonine protein kinase
TthHB5008_02400	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthHB5008_02440	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthHB5008_02450	COG0300	oxidoreductase activity
TthHB5008_02480	COG0717	Belongs to the dCTP deaminase family
TthHB5008_02490	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthHB5008_02500	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthHB5008_02510	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5008_02530	COG0583	DNA-binding transcription factor activity
TthHB5008_02540	COG3546	catalase activity
TthHB5008_02550	COG0758	DNA mediated transformation
TthHB5008_02550	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHB5008_02560	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthHB5008_02580	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5008_02600	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthHB5008_02610	COG0442	prolyl-tRNA aminoacylation
TthHB5008_02620	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthHB5008_02660	COG0303	'Molybdopterin
TthHB5008_02670	COG0513	Belongs to the DEAD box helicase family
TthHB5008_02680	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthHB5008_02700	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthHB5008_02730	COG2070	2-Nitropropane dioxygenase
TthHB5008_02760	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthHB5008_02770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHB5008_02780	COG0018	arginyl-trna synthetase
TthHB5008_02790	COG1007	ATP synthesis coupled electron transport
TthHB5008_02800	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5008_02810	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthHB5008_02820	COG0713	ATP synthesis coupled electron transport
TthHB5008_02830	COG0839	Belongs to the complex I subunit 6 family
TthHB5008_02840	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5008_02850	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthHB5008_02860	COG1034	ATP synthesis coupled electron transport
TthHB5008_02870	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthHB5008_02880	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthHB5008_02890	COG0649	NAD binding
TthHB5008_02900	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5008_02910	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5008_02920	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5008_02930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthHB5008_02950	COG4712	double-strand break repair protein
TthHB5008_02980	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthHB5008_03010	COG0135	phosphoribosylanthranilate isomerase activity
TthHB5008_03020	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHB5008_03020	COG1372	Participates in initiation and elongation during chromosome replication
TthHB5008_03030	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthHB5008_03050	COG2720	vancomycin resistance protein
TthHB5008_03060	COG1126	abc transporter atp-binding protein
TthHB5008_03120	COG0277	FAD linked oxidase domain protein
TthHB5008_03140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthHB5008_03150	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthHB5008_03180	COG0314	molybdopterin synthase activity
TthHB5008_03190	COG1420	regulation of RNA biosynthetic process
TthHB5008_03200	COG0347	Belongs to the P(II) protein family
TthHB5008_03210	COG0004	ammonium transporteR
TthHB5008_03230	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthHB5008_03260	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHB5008_03290	COG1597	lipid kinase activity
TthHB5008_03320	COG0436	Aminotransferase
TthHB5008_03340	COG0569	domain protein
TthHB5008_03340	COG0475	glutathione-regulated potassium exporter activity
TthHB5008_03360	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthHB5008_03380	COG0277	FAD linked oxidase domain protein
TthHB5008_03460	COG2801	Transposase and inactivated derivatives
TthHB5008_03500	COG2002	toxin-antitoxin pair type II binding
TthHB5008_03590	COG0667	Aldo Keto reductase
TthHB5008_03670	COG1067	ATP-dependent peptidase activity
TthHB5008_03680	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthHB5008_03700	COG0745	RESPONSE REGULATOR receiver
TthHB5008_03710	COG2105	PFAM AIG2 family protein
TthHB5008_03720	COG0297	glycogen (starch) synthase activity
TthHB5008_03740	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthHB5008_03750	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthHB5008_03780	COG0142	geranyltranstransferase activity
TthHB5008_03800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthHB5008_03810	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_03820	COG0492	ferredoxin-NADP+ reductase activity
TthHB5008_03840	COG0792	nuclease activity
TthHB5008_03850	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthHB5008_03880	COG1175	transmembrane transport
TthHB5008_03890	COG0395	ABC-type sugar transport system, permease component
TthHB5008_03950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthHB5008_03960	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthHB5008_03970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHB5008_03980	COG0805	protein transport
TthHB5008_03990	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHB5008_03990	COG1605	Chorismate mutase
TthHB5008_04010	COG3573	Dehydrogenase
TthHB5008_04030	COG0346	lactoylglutathione lyase activity
TthHB5008_04110	COG1063	alcohol dehydrogenase
TthHB5008_04170	COG2255	four-way junction helicase activity
TthHB5008_04180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthHB5008_04190	COG0564	pseudouridine synthase activity
TthHB5008_04220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthHB5008_04230	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthHB5008_04240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthHB5008_04250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthHB5008_04270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthHB5008_04280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthHB5008_04290	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthHB5008_04360	COG0778	Nitroreductase
TthHB5008_04400	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHB5008_04410	COG0131	Imidazoleglycerol-phosphate dehydratase
TthHB5008_04420	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthHB5008_04430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthHB5008_04440	COG0516	GMP reductase activity
TthHB5008_04440	COG0517	IMP dehydrogenase activity
TthHB5008_04470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthHB5008_04500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHB5008_04550	COG0706	membrane insertase activity
TthHB5008_04560	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthHB5008_04570	COG0594	ribonuclease P activity
TthHB5008_04600	COG1022	Amp-dependent synthetase and ligase
TthHB5008_04650	COG1121	(ABC) transporter
TthHB5008_04660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthHB5008_04670	COG1959	2 iron, 2 sulfur cluster binding
TthHB5008_04680	COG1104	cysteine desulfurase activity
TthHB5008_04690	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthHB5008_04700	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthHB5008_04730	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_04770	COG0492	ferredoxin-NADP+ reductase activity
TthHB5008_04780	COG3321	synthase
TthHB5008_04780	COG0604	alcohol dehydrogenase
TthHB5008_04780	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_04790	COG0747	negative chemotaxis
TthHB5008_04800	COG0601	transmembrane transport
TthHB5008_04810	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5008_04840	COG0517	IMP dehydrogenase activity
TthHB5008_04850	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHB5008_04860	COG2104	thiamine diphosphate biosynthetic process
TthHB5008_04870	COG0037	tRNA processing
TthHB5008_04900	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthHB5008_04920	COG0366	Alpha amylase catalytic
TthHB5008_04930	COG2226	methyltransferase
TthHB5008_04940	COG2226	methyltransferase
TthHB5008_04950	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthHB5008_04970	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthHB5008_04980	COG3744	PilT protein domain protein
TthHB5008_05000	COG0460	homoserine dehydrogenase
TthHB5008_05020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthHB5008_05080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthHB5008_05120	COG0247	lactate metabolic process
TthHB5008_05130	COG0277	FAD linked oxidase domain protein
TthHB5008_05140	COG0277	FAD linked oxidase domain protein
TthHB5008_05150	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthHB5008_05160	COG1414	Transcriptional regulator
TthHB5008_05170	COG0789	Transcriptional regulator
TthHB5008_05190	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5008_05200	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHB5008_05270	COG0861	Integral membrane protein TerC family
TthHB5008_05280	COG2151	metal-sulfur cluster biosynthetic enzyme
TthHB5008_05290	COG0281	malic enzyme
TthHB5008_05320	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthHB5008_05330	COG0509	glycine decarboxylation via glycine cleavage system
TthHB5008_05340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHB5008_05350	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHB5008_05360	COG0196	riboflavin kinase activity
TthHB5008_05410	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthHB5008_05420	COG2813	Specifically methylates the guanine in position
TthHB5008_05430	COG0527	aspartate kinase activity
TthHB5008_05490	COG4956	integral membrane protein (PIN domain superfamily)
TthHB5008_05500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthHB5008_05510	COG0542	response to heat
TthHB5008_05520	COG0423	glycine-tRNA ligase activity
TthHB5008_05540	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthHB5008_05580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHB5008_05580	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5008_05600	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthHB5008_05620	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthHB5008_05640	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5008_05650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHB5008_05660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthHB5008_05670	COG0114	fumarate hydratase activity
TthHB5008_05680	COG0183	Belongs to the thiolase family
TthHB5008_05710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthHB5008_05720	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthHB5008_05750	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthHB5008_05760	COG1254	Belongs to the acylphosphatase family
TthHB5008_05800	COG1063	alcohol dehydrogenase
TthHB5008_05850	COG2133	pyrroloquinoline quinone binding
TthHB5008_05870	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthHB5008_05880	COG0154	amidase activity
TthHB5008_05930	COG0572	uridine kinase
TthHB5008_05940	COG3842	ATPase activity
TthHB5008_05970	COG4475	Protein of unknown function (DUF436)
TthHB5008_06080	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHB5008_06090	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthHB5008_06100	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthHB5008_06130	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthHB5008_06140	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthHB5008_06150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthHB5008_06160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthHB5008_06180	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5008_06210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthHB5008_06220	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthHB5008_06230	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthHB5008_06250	COG3870	Protein conserved in bacteria
TthHB5008_06260	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthHB5008_06280	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthHB5008_06290	COG0740	serine-type endopeptidase activity
TthHB5008_06300	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthHB5008_06310	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthHB5008_06320	COG0646	methionine synthase
TthHB5008_06320	COG1410	methionine synthase
TthHB5008_06340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHB5008_06390	COG1692	metallophosphoesterase
TthHB5008_06400	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthHB5008_06410	COG1970	mechanosensitive ion channel activity
TthHB5008_06440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHB5008_06460	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthHB5008_06470	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthHB5008_06630	COG0438	transferase activity, transferring glycosyl groups
TthHB5008_06670	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
TthHB5008_06680	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHB5008_06720	COG0489	protein tyrosine kinase activity
TthHB5008_06740	COG2264	protein methyltransferase activity
TthHB5008_06750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthHB5008_06810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHB5008_06810	COG0574	Belongs to the PEP-utilizing enzyme family
TthHB5008_06830	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthHB5008_06840	COG2046	Belongs to the sulfate adenylyltransferase family
TthHB5008_06850	COG1648	precorrin-2 dehydrogenase activity
TthHB5008_06850	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5008_06860	COG0730	response to heat
TthHB5008_06870	COG0175	sulfate reduction
TthHB5008_06880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5008_06880	COG1648	precorrin-2 dehydrogenase activity
TthHB5008_06890	COG1587	Uroporphyrinogen-III synthase
TthHB5008_06900	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthHB5008_06920	COG0352	thiamine-phosphate diphosphorylase activity
TthHB5008_06930	COG2104	thiamine diphosphate biosynthetic process
TthHB5008_06940	COG2022	thiamine diphosphate biosynthetic process
TthHB5008_06950	COG2022	thiamine diphosphate biosynthetic process
TthHB5008_06950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5008_06960	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthHB5008_06970	COG0477	Major facilitator Superfamily
TthHB5008_06980	COG0352	thiamine-phosphate diphosphorylase activity
TthHB5008_06980	COG0351	phosphomethylpyrimidine kinase
TthHB5008_07040	COG1175	transmembrane transport
TthHB5008_07060	COG1940	carbohydrate kinase activity
TthHB5008_07070	COG0183	Belongs to the thiolase family
TthHB5008_07120	COG2030	dehydratase
TthHB5008_07140	COG0596	Alpha beta hydrolase
TthHB5008_07150	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5008_07180	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHB5008_07180	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHB5008_07200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthHB5008_07220	COG0195	Participates in both transcription termination and antitermination
TthHB5008_07230	COG0779	Required for maturation of 30S ribosomal subunits
TthHB5008_07240	COG0739	heme binding
TthHB5008_07250	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthHB5008_07260	COG0640	Transcriptional regulator
TthHB5008_07270	COG2217	Heavy metal translocating P-type atpase
TthHB5008_07280	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthHB5008_07290	COG0017	Asparaginyl-tRNA synthetase
TthHB5008_07300	COG0561	phosphatase activity
TthHB5008_07310	COG0384	phenazine biosynthesis protein PhzF
TthHB5008_07330	COG0124	histidyl-tRNA synthetase
TthHB5008_07350	COG3842	ATPase activity
TthHB5008_07380	COG1573	uracil-dna glycosylase
TthHB5008_07420	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthHB5008_07430	COG0519	Catalyzes the synthesis of GMP from XMP
TthHB5008_07430	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHB5008_07450	COG1316	TRANSCRIPTIONal
TthHB5008_07460	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthHB5008_07560	COG0295	cytidine deaminase activity
TthHB5008_07580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHB5008_07600	COG1760	l-serine dehydratase
TthHB5008_07620	COG0481	GTPase activity
TthHB5008_07640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHB5008_07670	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_07720	COG0405	Gamma-glutamyltransferase
TthHB5008_07760	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthHB5008_07770	COG2873	o-acetylhomoserine
TthHB5008_07800	COG1063	alcohol dehydrogenase
TthHB5008_07820	COG3191	aminopeptidase activity
TthHB5008_07830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHB5008_07840	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHB5008_07850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthHB5008_07870	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthHB5008_07890	COG0167	dihydroorotate dehydrogenase activity
TthHB5008_07920	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TthHB5008_07930	COG0540	Belongs to the ATCase OTCase family
TthHB5008_07940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TthHB5008_07960	COG0730	response to heat
TthHB5008_07970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthHB5008_07990	COG1960	acyl-CoA dehydrogenase activity
TthHB5008_08000	COG0456	acetyltransferase
TthHB5008_08020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthHB5008_08030	COG0009	L-threonylcarbamoyladenylate synthase
TthHB5008_08040	COG1459	type II secretion system
TthHB5008_08070	COG0277	FAD linked oxidase domain protein
TthHB5008_08110	COG0287	Prephenate dehydrogenase
TthHB5008_08120	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHB5008_08130	COG2514	catechol 2,3-dioxygenase activity
TthHB5008_08140	COG2353	YceI-like domain
TthHB5008_08150	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHB5008_08160	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHB5008_08200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5008_08210	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthHB5008_08230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthHB5008_08240	COG0151	Belongs to the GarS family
TthHB5008_08250	COG5002	protein histidine kinase activity
TthHB5008_08250	COG2176	DNA-directed DNA polymerase activity
TthHB5008_08310	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthHB5008_08330	COG0217	transcriptional regulatory protein
TthHB5008_08340	COG4651	solute:proton antiporter activity
TthHB5008_08340	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthHB5008_08350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthHB5008_08360	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthHB5008_08370	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHB5008_08380	COG1674	ftsk spoiiie
TthHB5008_08410	COG0517	IMP dehydrogenase activity
TthHB5008_08430	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5008_08430	COG0617	tRNA 3'-terminal CCA addition
TthHB5008_08430	COG3620	sequence-specific DNA binding
TthHB5008_08450	COG1994	Peptidase M50
TthHB5008_08460	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthHB5008_08480	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHB5008_08510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHB5008_08520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHB5008_08530	COG2719	SpoVR family
TthHB5008_08540	COG2718	Belongs to the UPF0229 family
TthHB5008_08550	COG2766	serine protein kinase
TthHB5008_08600	COG2137	regulation of response to DNA damage stimulus
TthHB5008_08620	COG2359	stage V sporulation protein S
TthHB5008_08630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHB5008_08640	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthHB5008_08660	COG0463	Glycosyl transferase, family 2
TthHB5008_08670	COG0750	zinc metalloprotease
TthHB5008_08680	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthHB5008_08690	COG4589	Belongs to the CDS family
TthHB5008_08700	COG0233	cytoplasmic translational termination
TthHB5008_08710	COG0528	UMP kinase activity
TthHB5008_08720	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthHB5008_08730	COG0052	Belongs to the universal ribosomal protein uS2 family
TthHB5008_08970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthHB5008_08980	COG0494	nUDIX hydrolase
TthHB5008_09040	COG0402	S-adenosylhomocysteine deaminase activity
TthHB5008_09060	COG4948	Mandelate Racemase Muconate Lactonizing
TthHB5008_09070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthHB5008_09080	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5008_09090	COG1811	Na channel or pump
TthHB5008_09100	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5008_09100	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthHB5008_09130	COG1215	transferase activity, transferring glycosyl groups
TthHB5008_09150	COG1215	transferase activity, transferring glycosyl groups
TthHB5008_09170	COG0438	transferase activity, transferring glycosyl groups
TthHB5008_09180	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthHB5008_09230	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHB5008_09230	COG1024	Enoyl-CoA hydratase
TthHB5008_09240	COG0183	Belongs to the thiolase family
TthHB5008_09250	COG1960	acyl-CoA dehydrogenase activity
TthHB5008_09260	COG0215	cysteine-tRNA ligase activity
TthHB5008_09270	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthHB5008_09290	COG2738	Putative neutral zinc metallopeptidase
TthHB5008_09320	COG1196	nuclear chromosome segregation
TthHB5008_09350	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthHB5008_09360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHB5008_09360	COG3153	acetyltransferase
TthHB5008_09370	COG1268	BioY protein
TthHB5008_09390	COG0126	phosphoglycerate kinase activity
TthHB5008_09400	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthHB5008_09410	COG0824	Thioesterase
TthHB5008_09430	COG0557	exoribonuclease II activity
TthHB5008_09440	COG1355	regulation of microtubule-based process
TthHB5008_09450	COG0617	tRNA 3'-terminal CCA addition
TthHB5008_09450	COG1353	crispr-associated protein
TthHB5008_09460	COG0237	dephospho-CoA kinase activity
TthHB5008_09480	COG0742	ribosomal rna small subunit methyltransferase
TthHB5008_09490	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthHB5008_09500	COG0138	bifunctional purine biosynthesis protein purh
TthHB5008_09510	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthHB5008_09540	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthHB5008_09650	COG0149	triose-phosphate isomerase activity
TthHB5008_09660	COG3239	Fatty acid desaturase
TthHB5008_09670	COG1490	D-aminoacyl-tRNA deacylase activity
TthHB5008_09680	COG1307	EDD domain protein, DegV family
TthHB5008_09690	COG1307	EDD domain protein, DegV family
TthHB5008_09700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthHB5008_09710	COG1510	regulation of RNA biosynthetic process
TthHB5008_09730	COG3769	mannosylglycerate metabolic process
TthHB5008_09760	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5008_09770	COG2368	4-hydroxyphenylacetate
TthHB5008_09780	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthHB5008_09840	COG2050	protein possibly involved in aromatic compounds catabolism
TthHB5008_09850	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHB5008_09870	COG2030	dehydratase
TthHB5008_09870	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5008_09910	COG3396	Phenylacetate-CoA oxygenase
TthHB5008_09930	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthHB5008_10000	COG5297	Belongs to the glycosyl hydrolase family 6
TthHB5008_10000	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
TthHB5008_10070	COG1192	Involved in chromosome partitioning
TthHB5008_10080	COG1475	DNA binding
TthHB5008_10100	COG1475	DNA binding
TthHB5008_10150	COG4966	pilus assembly protein PilW
TthHB5008_10200	COG3345	alpha-galactosidase
TthHB5008_10210	COG1085	galactose-1-phosphate uridylyltransferase
TthHB5008_10250	COG1304	FMN binding
TthHB5008_10270	COG1487	ribonuclease activity
TthHB5008_10320	COG2124	cytochrome p450
TthHB5008_10340	COG1562	ergosterol biosynthetic process
TthHB5008_10360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5008_10420	COG0702	epimerase
TthHB5008_10430	COG1233	COG1233 Phytoene dehydrogenase and related
TthHB5008_10470	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHB5008_10480	COG2723	6-phospho-beta-galactosidase activity
TthHB5008_10500	COG1175	transmembrane transport
TthHB5008_10530	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_10560	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_10570	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHB5008_10590	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthHB5008_10600	COG0800	Aldolase
TthHB5008_10620	COG1175	transmembrane transport
TthHB5008_10630	COG0395	ABC-type sugar transport system, permease component
TthHB5008_10680	COG1785	Belongs to the alkaline phosphatase family
TthHB5008_10690	COG1492	cobalamin metabolic process
TthHB5008_10710	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHB5008_10750	COG0778	Nitroreductase
TthHB5008_10760	COG1648	precorrin-2 dehydrogenase activity
TthHB5008_10760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5008_10850	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthHB5008_10860	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthHB5008_10870	COG0588	phosphoglycerate mutase activity
TthHB5008_10900	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthHB5008_10930	COG1797	cobyrinic acid a,c-diamide synthase activity
TthHB5008_11000	COG2211	Major facilitator Superfamily
TthHB5008_11040	COG2211	Major facilitator Superfamily
TthHB5008_11100	COG2801	Transposase and inactivated derivatives
TthHB5008_11140	COG1337	RAMP superfamily
TthHB5008_11220	COG2801	Transposase and inactivated derivatives
TthHB5008_11270	COG1960	acyl-CoA dehydrogenase activity
TthHB5008_11290	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_11300	COG2030	dehydratase
TthHB5008_11300	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5008_11320	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5008_11330	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5008_11370	COG0588	phosphoglycerate mutase activity
TthHB5008_11640	COG2801	Transposase and inactivated derivatives
TthHB5008_11680	COG2329	Antibiotic biosynthesis monooxygenase
TthHB5008_11700	COG4558	Periplasmic binding protein
TthHB5008_11710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHB5008_11720	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthHB5008_11740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TthHB5008_11770	COG3706	GGDEF domain
TthHB5008_11910	COG0395	ABC-type sugar transport system, permease component
TthHB5008_11950	COG1980	fructose-bisphosphate aldolase activity
TthHB5008_11960	COG1733	regulation of RNA biosynthetic process
TthHB5008_11970	COG2193	ferroxidase activity
TthHB5008_11980	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthHB5008_11990	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthHB5008_12010	COG1331	Highly conserved protein containing a thioredoxin domain
TthHB5008_12020	COG0183	Belongs to the thiolase family
TthHB5008_12030	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthHB5008_12100	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5008_12120	COG0248	Ppx GppA phosphatase
TthHB5008_12130	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthHB5008_12190	COG0745	RESPONSE REGULATOR receiver
TthHB5008_12200	COG2205	protein histidine kinase activity
TthHB5008_12240	COG1136	(ABC) transporter
TthHB5008_12250	COG0577	efflux transmembrane transporter activity
TthHB5008_12250	COG1136	(ABC) transporter
TthHB5008_12330	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5008_12380	COG0582	viral genome integration into host DNA
TthHB5008_12390	COG2897	thiosulfate sulfurtransferase activity
TthHB5008_12400	COG1760	l-serine dehydratase
TthHB5008_12410	COG2197	response regulator
TthHB5008_12420	COG0335	large ribosomal subunit rRNA binding
TthHB5008_12430	COG0336	Belongs to the RNA methyltransferase TrmD family
TthHB5008_12440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthHB5008_12450	COG1837	Belongs to the UPF0109 family
TthHB5008_12460	COG0228	four-way junction DNA binding
TthHB5008_12490	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5008_12500	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5008_12500	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5008_12510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthHB5008_12530	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthHB5008_12550	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthHB5008_12560	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthHB5008_12570	COG1702	phosphate starvation-inducible protein PhoH
TthHB5008_12590	COG4864	UPF0365 protein
TthHB5008_12610	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthHB5008_12650	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5008_12650	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5008_12670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHB5008_12690	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthHB5008_12700	COG1397	ADP-ribosylglycohydrolase
TthHB5008_12710	COG2239	Acts as a magnesium transporter
TthHB5008_12730	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHB5008_12730	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHB5008_12750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHB5008_12750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHB5008_12760	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthHB5008_12770	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthHB5008_12780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthHB5008_12790	COG0006	proline dipeptidase activity
TthHB5008_12810	COG0739	heme binding
TthHB5008_12830	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthHB5008_12840	COG0254	rRNA binding
TthHB5008_12860	COG2001	Belongs to the MraZ family
TthHB5008_12870	COG0275	rRNA processing
TthHB5008_12890	COG0768	penicillin binding
TthHB5008_12900	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthHB5008_12920	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHB5008_12930	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthHB5008_12940	COG0772	Belongs to the SEDS family
TthHB5008_12950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthHB5008_12960	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthHB5008_12970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthHB5008_13010	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthHB5008_13030	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHB5008_13050	COG0159	tryptophan synthase activity
TthHB5008_13060	COG0133	tryptophan synthase activity
TthHB5008_13070	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthHB5008_13080	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHB5008_13090	COG1744	ABC transporter substrate-binding protein PnrA-like
TthHB5008_13100	COG3845	ABC transporter
TthHB5008_13200	COG0438	transferase activity, transferring glycosyl groups
TthHB5008_13210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHB5008_13230	COG0039	L-malate dehydrogenase activity
TthHB5008_13240	COG2819	hydrolase of the alpha beta superfamily
TthHB5008_13250	COG0861	Integral membrane protein TerC family
TthHB5008_13270	COG0247	lactate metabolic process
TthHB5008_13270	COG2181	nitrate reductase activity
TthHB5008_13290	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthHB5008_13300	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthHB5008_13310	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthHB5008_13330	COG0439	Biotin carboxylase
TthHB5008_13340	COG0511	ligase activity, forming carbon-carbon bonds
TthHB5008_13350	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthHB5008_13390	COG0010	Belongs to the arginase family
TthHB5008_13420	COG1100	Small GTP-binding protein
TthHB5008_13440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5008_13450	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHB5008_13480	COG2814	Major facilitator Superfamily
TthHB5008_13500	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthHB5008_13510	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHB5008_13520	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthHB5008_13540	COG0745	RESPONSE REGULATOR receiver
TthHB5008_13550	COG5002	protein histidine kinase activity
TthHB5008_13560	COG1960	acyl-CoA dehydrogenase activity
TthHB5008_13570	COG2086	electron transfer activity
TthHB5008_13580	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthHB5008_13600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHB5008_13610	COG1573	uracil-dna glycosylase
TthHB5008_13620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHB5008_13620	COG1796	DNA polymerase
TthHB5008_13650	COG2309	aminopeptidase activity
TthHB5008_13690	COG2873	o-acetylhomoserine
TthHB5008_13700	COG2358	TRAP transporter, solute receptor (TAXI family
TthHB5008_13720	COG1126	abc transporter atp-binding protein
TthHB5008_13740	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHB5008_13750	COG0134	indole-3-glycerol-phosphate synthase activity
TthHB5008_13760	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthHB5008_13780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthHB5008_13810	COG0765	amino acid transport
TthHB5008_13820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthHB5008_13840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthHB5008_13850	COG0569	domain protein
TthHB5008_13860	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5008_13870	COG1426	Protein conserved in bacteria
TthHB5008_13880	COG2313	pseudouridylate synthase activity
TthHB5008_13900	COG3001	Fructosamine kinase
TthHB5008_13910	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHB5008_13930	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthHB5008_13960	COG0012	GTP binding
TthHB5008_13970	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthHB5008_13990	COG0424	maF-like protein
TthHB5008_14020	COG0768	penicillin binding
TthHB5008_14040	COG2322	membrane
TthHB5008_14080	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthHB5008_14090	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHB5008_14110	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthHB5008_14140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5008_14160	COG2801	Transposase and inactivated derivatives
TthHB5008_14220	COG1131	(ABC) transporter
TthHB5008_14250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHB5008_14280	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthHB5008_14290	COG0440	acetolactate synthase activity
TthHB5008_14300	COG0028	Belongs to the TPP enzyme family
TthHB5008_14310	COG0492	ferredoxin-NADP+ reductase activity
TthHB5008_14320	COG4970	Tfp pilus assembly protein FimT
TthHB5008_14370	COG2165	general secretion pathway protein
TthHB5008_14430	COG0180	Tryptophanyl-tRNA synthetase
TthHB5008_14440	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHB5008_14450	COG0066	3-isopropylmalate dehydratase activity
TthHB5008_14460	COG0473	3-isopropylmalate dehydrogenase activity
TthHB5008_14490	COG0300	oxidoreductase activity
TthHB5008_14500	COG0129	dihydroxy-acid dehydratase activity
TthHB5008_14520	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthHB5008_14530	COG1177	transmembrane transport
TthHB5008_14540	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthHB5008_14550	COG3842	ATPase activity
TthHB5008_14560	COG0772	Belongs to the SEDS family
TthHB5008_14570	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthHB5008_14580	COG2894	cell division
TthHB5008_14590	COG1733	regulation of RNA biosynthetic process
TthHB5008_14610	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5008_14610	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5008_14630	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5008_14640	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5008_14650	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5008_14660	COG0653	protein targeting
TthHB5008_14670	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthHB5008_14710	COG0393	Putative heavy-metal-binding
TthHB5008_14720	COG1111	helicase
TthHB5008_14720	COG1205	dead DEAH box helicase
TthHB5008_14750	COG0358	DNA primase activity
TthHB5008_14770	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHB5008_14780	COG0612	Peptidase, M16
TthHB5008_14790	COG0612	Peptidase, M16
TthHB5008_14800	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthHB5008_14830	COG1394	ATPase activity, coupled to movement of substances
TthHB5008_14840	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthHB5008_14850	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthHB5008_14860	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHB5008_14870	COG1527	subunit (C
TthHB5008_14880	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHB5008_14900	COG1269	ATP hydrolysis coupled proton transport
TthHB5008_14950	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHB5008_14970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5008_15000	COG0419	ATPase involved in DNA repair
TthHB5008_15010	COG0420	3'-5' exonuclease activity
TthHB5008_15050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthHB5008_15060	COG2884	Cell division ATP-binding protein ftsE
TthHB5008_15070	COG0793	Belongs to the peptidase S41A family
TthHB5008_15090	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5008_15090	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5008_15100	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthHB5008_15110	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthHB5008_15130	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHB5008_15140	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHB5008_15150	COG1129	ABC transporter
TthHB5008_15160	COG0746	molybdenum cofactor guanylyltransferase activity
TthHB5008_15180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5008_15220	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthHB5008_15230	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHB5008_15240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthHB5008_15260	COG1994	Peptidase M50
TthHB5008_15260	COG0517	IMP dehydrogenase activity
TthHB5008_15270	COG2358	TRAP transporter, solute receptor (TAXI family
TthHB5008_15310	COG0788	formyltetrahydrofolate deformylase activity
TthHB5008_15320	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthHB5008_15330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthHB5008_15340	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthHB5008_15380	COG0737	Belongs to the 5'-nucleotidase family
TthHB5008_15390	COG0174	glutamine synthetase
TthHB5008_15410	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHB5008_15450	COG0747	negative chemotaxis
TthHB5008_15460	COG0601	transmembrane transport
TthHB5008_15470	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5008_15490	COG0285	dihydrofolate synthase activity
TthHB5008_15500	COG1132	(ABC) transporter
TthHB5008_15510	COG1132	(ABC) transporter
TthHB5008_15520	COG0372	Belongs to the citrate synthase family
TthHB5008_15530	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthHB5008_15540	COG1482	cell wall glycoprotein biosynthetic process
TthHB5008_15560	COG1515	deoxyribonuclease V activity
TthHB5008_15580	COG0776	regulation of translation
TthHB5008_15610	COG2197	response regulator
TthHB5008_15620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthHB5008_15630	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthHB5008_15640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthHB5008_15650	COG1324	tolerance protein
TthHB5008_15680	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5008_15720	COG2205	protein histidine kinase activity
TthHB5008_15740	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthHB5008_15760	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthHB5008_15790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TthHB5008_15800	COG0247	lactate metabolic process
TthHB5008_15810	COG1139	Iron-sulfur cluster binding protein
TthHB5008_15820	COG1556	Lactate utilization protein
TthHB5008_15840	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHB5008_15850	COG2815	serine threonine protein kinase
TthHB5008_15850	COG0515	serine threonine protein kinase
TthHB5008_15870	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthHB5008_15890	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthHB5008_15940	COG0473	3-isopropylmalate dehydrogenase activity
TthHB5008_15990	COG1450	Type ii and iii secretion system protein
TthHB5008_16000	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthHB5008_16010	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthHB5008_16020	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthHB5008_16030	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHB5008_16030	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthHB5008_16040	COG0736	holo-[acyl-carrier-protein] synthase activity
TthHB5008_16070	COG1160	GTP binding
TthHB5008_16080	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthHB5008_16090	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthHB5008_16090	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthHB5008_16100	COG0083	homoserine kinase activity
TthHB5008_16120	COG0268	Binds directly to 16S ribosomal RNA
TthHB5008_16140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthHB5008_16150	COG0723	plastoquinol--plastocyanin reductase activity
TthHB5008_16170	COG3088	subunit of a heme lyase
TthHB5008_16170	COG4235	cytochrome complex assembly
TthHB5008_16180	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHB5008_16190	COG1138	Cytochrome C-type biogenesis protein
TthHB5008_16200	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthHB5008_16210	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHB5008_16220	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHB5008_16230	COG4133	protoheme IX ABC transporter activity
TthHB5008_16240	COG0785	Cytochrome C biogenesis protein
TthHB5008_16250	COG3258	Cytochrome c
TthHB5008_16270	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHB5008_16300	COG3258	Cytochrome c
TthHB5008_16310	COG2010	Cytochrome c
TthHB5008_16320	COG0737	Belongs to the 5'-nucleotidase family
TthHB5008_16330	COG2010	Cytochrome c
TthHB5008_16340	COG3258	Cytochrome c
TthHB5008_16380	COG2010	Cytochrome c
TthHB5008_16390	COG3842	ATPase activity
TthHB5008_16450	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5008_16450	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5008_16460	COG3360	Dodecin
TthHB5008_16490	COG1024	Enoyl-CoA hydratase
TthHB5008_16500	COG0813	purine-nucleoside phosphorylase activity
TthHB5008_16510	COG1136	(ABC) transporter
TthHB5008_16520	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5008_16530	COG2045	Belongs to the ComB family
TthHB5008_16550	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthHB5008_16570	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthHB5008_16590	COG0107	imidazoleglycerol-phosphate synthase activity
TthHB5008_16600	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthHB5008_16600	COG0140	phosphoribosyl-ATP diphosphatase activity
TthHB5008_16620	COG1494	fructose-1,6-bisphosphatase
TthHB5008_16630	COG0686	Belongs to the AlaDH PNT family
TthHB5008_16640	COG0427	acetyl-CoA hydrolase
TthHB5008_16650	COG0084	hydrolase, TatD family'
TthHB5008_16660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthHB5008_16680	COG0017	Asparaginyl-tRNA synthetase
TthHB5008_16700	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthHB5008_16730	COG2009	succinate dehydrogenase
TthHB5008_16740	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHB5008_16800	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5008_16810	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthHB5008_16820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthHB5008_16830	COG0504	CTP synthase activity
TthHB5008_16850	COG0070	glutamate synthase
TthHB5008_16850	COG0067	glutamate synthase
TthHB5008_16850	COG0069	glutamate synthase activity
TthHB5008_16870	COG0840	transmembrane signaling receptor activity
TthHB5008_16880	COG0305	Participates in initiation and elongation during chromosome replication
TthHB5008_16900	COG0475	glutathione-regulated potassium exporter activity
TthHB5008_16910	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5008_16910	COG0617	tRNA 3'-terminal CCA addition
TthHB5008_16910	COG0517	IMP dehydrogenase activity
TthHB5008_16940	COG0475	glutathione-regulated potassium exporter activity
TthHB5008_16950	COG0490	domain, Protein
TthHB5008_16990	COG3118	belongs to the thioredoxin family
TthHB5008_17050	COG0542	response to heat
TthHB5008_17060	COG0789	Transcriptional regulator
TthHB5008_17070	COG0484	heat shock protein binding
TthHB5008_17080	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthHB5008_17090	COG0443	Heat shock 70 kDa protein
TthHB5008_17100	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthHB5008_17110	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthHB5008_17120	COG0616	signal peptide processing
TthHB5008_17130	COG1714	RDD family
TthHB5008_17150	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthHB5008_17160	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthHB5008_17170	COG0714	Associated with various cellular activities
TthHB5008_17180	COG0574	Belongs to the PEP-utilizing enzyme family
TthHB5008_17180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHB5008_17190	COG1272	protein, Hemolysin III
TthHB5008_17210	COG5002	protein histidine kinase activity
TthHB5008_17210	COG3850	Histidine kinase
TthHB5008_17240	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthHB5008_17270	COG1011	Hydrolase
TthHB5008_17310	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthHB5008_17330	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthHB5008_17350	COG0047	phosphoribosylformylglycinamidine synthase activity
TthHB5008_17370	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthHB5008_17380	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthHB5008_17390	COG0116	Belongs to the methyltransferase superfamily
TthHB5008_17420	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthHB5008_17430	COG0497	DNA recombination
TthHB5008_17450	COG0604	alcohol dehydrogenase
TthHB5008_17490	COG0585	pseudouridine synthase activity
TthHB5008_17520	COG0557	exoribonuclease II activity
TthHB5008_17530	COG0538	isocitrate dehydrogenase activity
TthHB5008_17540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5008_17670	COG0037	tRNA processing
TthHB5008_17670	COG0590	tRNA wobble adenosine to inosine editing
TthHB5008_17710	COG2050	protein possibly involved in aromatic compounds catabolism
TthHB5008_17730	COG0322	excinuclease ABC activity
TthHB5008_17740	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHB5008_17750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHB5008_17760	COG1854	S-ribosylhomocysteine lyase activity
TthHB5008_17770	COG0519	Catalyzes the synthesis of GMP from XMP
TthHB5008_17770	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHB5008_17790	COG4274	PFAM GYD family protein
TthHB5008_17800	COG0346	lactoylglutathione lyase activity
TthHB5008_17810	COG0328	RNA-DNA hybrid ribonuclease activity
TthHB5008_17820	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHB5008_17830	COG2095	MarC family integral membrane protein
TthHB5008_17840	COG1438	arginine binding
TthHB5008_17850	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthHB5008_17860	COG1758	RNA polymerase activity
TthHB5008_17870	COG0194	GDP metabolic process
TthHB5008_17890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthHB5008_17900	COG2385	sporulation resulting in formation of a cellular spore
TthHB5008_17910	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthHB5008_17930	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHB5008_18010	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHB5008_18020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHB5008_18030	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5008_18040	COG0506	proline dehydrogenase activity
TthHB5008_18070	COG0156	8-amino-7-oxononanoate synthase activity
TthHB5008_18080	COG0732	type I restriction modification DNA specificity domain
TthHB5008_18080	COG0827	DNA restriction-modification system
TthHB5008_18130	COG0187	DNA topoisomerase II activity
TthHB5008_18140	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthHB5008_18150	COG0193	aminoacyl-tRNA hydrolase activity
TthHB5008_18160	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthHB5008_18210	COG0515	serine threonine protein kinase
TthHB5008_18210	COG2815	serine threonine protein kinase
TthHB5008_18220	COG0631	protein serine/threonine phosphatase activity
TthHB5008_18240	COG2814	Major facilitator Superfamily
TthHB5008_18250	COG0113	porphobilinogen synthase activity
TthHB5008_18260	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthHB5008_18270	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthHB5008_18320	COG0823	Involved in the tonB-independent uptake of proteins
TthHB5008_18320	COG4946	Tricorn protease homolog
TthHB5008_18320	COG1506	peptidase
TthHB5008_18330	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthHB5008_18340	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthHB5008_18380	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthHB5008_18390	COG1011	Hydrolase
TthHB5008_18440	COG0537	adenosine 5'-monophosphoramidase activity
TthHB5008_18450	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5008_18460	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthHB5008_18470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthHB5008_18480	COG0071	Belongs to the small heat shock protein (HSP20) family
TthHB5008_18490	COG2897	thiosulfate sulfurtransferase activity
TthHB5008_18500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHB5008_18520	COG1764	response to oxidative stress
TthHB5008_18570	COG3842	ATPase activity
TthHB5008_18580	COG0101	tRNA pseudouridine synthase activity
TthHB5008_18590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5008_18610	COG0006	proline dipeptidase activity
TthHB5008_18620	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHB5008_18650	COG1166	arginine decarboxylase activity
TthHB5008_18670	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthHB5008_18680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthHB5008_18690	COG1611	Belongs to the LOG family
TthHB5008_18700	COG1193	negative regulation of DNA recombination
TthHB5008_18720	COG0366	Alpha amylase catalytic
TthHB5008_18790	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthHB5008_18800	COG0142	geranyltranstransferase activity
TthHB5008_18830	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthHB5008_18890	COG0203	ribosomal protein L17
TthHB5008_18900	COG0202	RNA polymerase activity
TthHB5008_18910	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthHB5008_18920	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthHB5008_18930	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthHB5008_18940	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthHB5008_18960	COG0563	adenylate kinase activity
TthHB5008_18970	COG0201	protein transport
TthHB5008_19020	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthHB5008_19030	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthHB5008_19040	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthHB5008_19080	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TthHB5008_19090	COG0255	Belongs to the universal ribosomal protein uL29 family
TthHB5008_19100	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthHB5008_19110	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthHB5008_19130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthHB5008_19140	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthHB5008_19150	COG0089	rRNA binding
TthHB5008_19160	COG0088	Forms part of the polypeptide exit tunnel
TthHB5008_19180	COG0051	transcription antitermination factor activity, RNA binding
TthHB5008_19190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHB5008_19210	COG0049	tRNA binding
TthHB5008_19240	COG0442	prolyl-tRNA aminoacylation
TthHB5008_19280	COG1115	amino acid carrier protein
TthHB5008_19320	COG1489	DNA binding
TthHB5008_19380	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthHB5008_19420	COG0432	Pfam Uncharacterised protein family UPF0047
TthHB5008_19430	COG3253	May function as heme-dependent peroxidase
TthHB5008_19440	COG0668	transmembrane transport
TthHB5008_19460	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthHB5008_19470	COG2217	Heavy metal translocating P-type atpase
TthHB5008_19510	COG0745	RESPONSE REGULATOR receiver
TthHB5008_19520	COG2205	protein histidine kinase activity
TthHB5008_19560	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHB5008_19570	COG2226	methyltransferase
TthHB5008_19630	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthHB5008_19640	COG0822	iron-sulfur transferase activity
TthHB5008_19680	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthHB5008_19700	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthHB5008_19710	COG0284	orotidine-5'-phosphate decarboxylase activity
TthHB5008_19730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthHB5008_19750	COG0416	fatty acid biosynthetic process
TthHB5008_19760	COG3118	belongs to the thioredoxin family
TthHB5008_19770	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHB5008_19780	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthHB5008_19800	COG0438	transferase activity, transferring glycosyl groups
TthHB5008_19850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthHB5008_19880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHB5008_19890	COG3706	GGDEF domain
TthHB5008_19960	COG0437	4 iron, 4 sulfur cluster binding
TthHB5008_20000	COG0825	malonyl-CoA metabolic process
TthHB5008_20010	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthHB5008_20080	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthHB5008_20130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthHB5008_20140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthHB5008_20150	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthHB5008_20160	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthHB5008_20220	COG0315	cyclic pyranopterin monophosphate synthase activity
TthHB5008_20240	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthHB5008_20270	COG1694	Mazg nucleotide pyrophosphohydrolase
TthHB5008_20280	COG1803	Methylglyoxal synthase
TthHB5008_20300	COG0301	tRNA thio-modification
TthHB5008_20310	COG0154	amidase activity
TthHB5008_20320	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthHB5008_20350	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthHB5008_20360	COG1607	acyl-coa hydrolase
TthHB5008_20380	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthHB5008_20390	COG4149	molybdate abc transporter
TthHB5008_20400	COG1840	ABC-type Fe3 transport system, periplasmic component
TthHB5008_20430	COG0235	Class ii aldolase
TthHB5008_20440	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthHB5008_20450	COG0085	RNA polymerase activity
TthHB5008_20470	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthHB5008_20480	COG1077	Cell shape determining protein MreB Mrl
TthHB5008_20490	COG1418	mRNA catabolic process
TthHB5008_20490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthHB5008_20500	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthHB5008_20510	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthHB5008_20520	COG1546	Belongs to the CinA family
TthHB5008_20520	COG1058	Belongs to the CinA family
TthHB5008_20530	COG0354	folic acid binding
TthHB5008_20560	COG4948	Mandelate Racemase Muconate Lactonizing
TthHB5008_20590	COG1175	transmembrane transport
TthHB5008_20610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthHB5008_20630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHB5008_20650	COG0577	efflux transmembrane transporter activity
TthHB5008_20650	COG1136	(ABC) transporter
TthHB5008_20660	COG4181	ATPase activity
TthHB5008_20670	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHB5008_20700	COG0396	ATPase activity
TthHB5008_20710	COG0719	Fe-S assembly protein
TthHB5008_20720	COG0719	Fe-S assembly protein
TthHB5008_20730	COG2146	nitrite reductase [NAD(P)H] activity
TthHB5008_20750	COG0512	Glutamine amidotransferase of anthranilate synthase
TthHB5008_20760	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHB5008_20840	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHB5008_20850	COG2226	methyltransferase
TthHB5008_20860	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHB5008_20870	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHB5008_20900	COG1774	PSP1 C-terminal conserved region
TthHB5008_20910	COG0470	DNA polymerase III
TthHB5008_20980	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthHB5008_20990	COG0302	gtp cyclohydrolase
TthHB5008_21030	COG1217	gtp-binding protein TYPA
TthHB5008_21050	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthHB5008_21070	COG0395	ABC-type sugar transport system, permease component
TthHB5008_21080	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthHB5008_21090	COG1131	(ABC) transporter
TthHB5008_21130	COG0556	nucleotide-excision repair
TthHB5008_21140	COG0497	DNA recombination
TthHB5008_21150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHB5008_21160	COG0445	tRNA wobble uridine modification
TthHB5008_21200	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthHB5008_21210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthHB5008_21210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHB5008_21220	COG1543	Belongs to the glycosyl hydrolase 57 family
TthHB5008_21230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHB5008_21240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHB5008_21270	COG0189	ligase activity
TthHB5008_21300	COG0066	3-isopropylmalate dehydratase activity
TthHB5008_21310	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHB5008_21320	COG1598	PFAM Uncharacterised protein family UPF0150
TthHB5008_21340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHB5008_21350	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthHB5008_21360	COG1960	acyl-CoA dehydrogenase activity
TthHB5008_21370	COG0163	prenyltransferase activity
TthHB5008_21420	COG1668	transmembrane transport
TthHB5008_21430	COG4555	ABC transporter
TthHB5008_21450	COG2096	Adenosyltransferase
TthHB5008_21480	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthHB5008_21490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthHB5008_21520	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthHB5008_21530	COG0723	plastoquinol--plastocyanin reductase activity
TthHB5008_21550	COG2010	Cytochrome c
TthHB5008_21600	COG1653	transport
TthHB5008_21610	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthHB5008_21620	COG1960	acyl-CoA dehydrogenase activity
TthHB5008_21640	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthHB5008_21680	COG0393	Putative heavy-metal-binding
TthHB5008_21700	COG3956	TIGRFAM MazG family protein
TthHB5008_21720	COG0693	protein deglycase activity
TthHB5008_21730	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHB5008_21750	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthHB5008_21760	COG1937	Protein conserved in bacteria
TthHB5008_21780	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthHB5008_21780	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthHB5008_21790	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthHB5008_21800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5008_21840	COG0205	6-phosphofructokinase activity
TthHB5008_21850	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthHB5008_21870	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthHB5008_21900	COG0658	competence protein
TthHB5008_21900	COG2333	competence protein COMEC
TthHB5008_21910	COG1475	DNA binding
TthHB5008_21920	COG1192	Involved in chromosome partitioning
TthHB5008_21930	COG0357	Ribosomal RNA small subunit methyltransferase G
TthHB5008_21940	COG0445	tRNA wobble uridine modification
TthHB5008_b21950	COG1475	DNA binding
TthHB5008_b21960	COG1192	Involved in chromosome partitioning
TthHB5008_b22010	COG4213	ABC transporter substrate-binding protein
TthHB5008_b22020	COG4214	carbohydrate transport
TthHB5008_b22030	COG1129	ABC transporter
TthHB5008_b22040	COG1940	carbohydrate kinase activity
TthHB5008_b22060	COG1070	Carbohydrate kinase
TthHB5008_b22080	COG0673	inositol 2-dehydrogenase activity
TthHB5008_b22090	COG0300	oxidoreductase activity
TthHB5008_b22130	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthHB5008_b22210	COG2002	toxin-antitoxin pair type II binding
TthHB5008_b22570	COG1074	ATP-dependent DNA helicase activity
TthHB5008_b22600	COG1203	CRISPR-associated helicase, Cas3
TthHB5008_b22740	COG0395	ABC-type sugar transport system, permease component
TthHB5008_b22750	COG1175	transmembrane transport
TthHB5008_b22790	COG1692	metallophosphoesterase
TthHB5008_b22860	COG1175	transmembrane transport
TthHB5008_b22900	COG3454	Phosphonate metabolism
TthHB5008_b22910	COG4778	phosphonate C-P lyase system protein PhnL
TthHB5008_b22930	COG3627	carbon phosphorus lyase activity
TthHB5008_b22970	COG3639	organic phosphonate transmembrane transporter activity
TthHB5008_b22990	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthHB5008_c23170	COG2801	Transposase and inactivated derivatives
TthHB5008_t00360	COG0544	peptidyl-prolyl cis-trans isomerase activity