locus-tag	class	description
TthHB5018_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthHB5018_00020	COG0592	DNA-directed DNA polymerase activity
TthHB5018_00030	COG0148	phosphopyruvate hydratase activity
TthHB5018_00040	COG0469	pyruvate kinase activity
TthHB5018_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHB5018_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthHB5018_00090	COG1842	Phage shock protein A
TthHB5018_00100	COG0406	alpha-ribazole phosphatase activity
TthHB5018_00110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthHB5018_00120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5018_00140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthHB5018_00150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthHB5018_00160	COG1496	oxidoreductase activity
TthHB5018_00170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthHB5018_00180	COG1278	Cold shock
TthHB5018_00190	COG1653	transport
TthHB5018_00220	COG0033	Phosphoglucomutase
TthHB5018_00260	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthHB5018_00260	COG0517	IMP dehydrogenase activity
TthHB5018_00270	COG1950	PFAM Membrane protein of
TthHB5018_00280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthHB5018_00300	COG0181	hydroxymethylbilane synthase activity
TthHB5018_00320	COG0285	dihydrofolate synthase activity
TthHB5018_00330	COG0436	Aminotransferase
TthHB5018_00340	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthHB5018_00390	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthHB5018_00400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthHB5018_00410	COG1993	acr, cog1993
TthHB5018_00420	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthHB5018_00450	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHB5018_00470	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthHB5018_00480	COG1335	isochorismatase
TthHB5018_00490	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthHB5018_00520	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthHB5018_00530	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthHB5018_00570	COG1660	Displays ATPase and GTPase activities
TthHB5018_00580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthHB5018_00640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHB5018_00640	COG1845	cytochrome c oxidase, subunit III
TthHB5018_00650	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5018_00650	COG2010	Cytochrome c
TthHB5018_00660	COG0109	protoheme IX farnesyltransferase activity
TthHB5018_00660	COG1612	heme a metabolic process
TthHB5018_00690	COG0343	queuine tRNA-ribosyltransferase activity
TthHB5018_00700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthHB5018_00710	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthHB5018_00760	COG1940	carbohydrate kinase activity
TthHB5018_00780	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHB5018_00790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5018_00810	COG1611	Belongs to the LOG family
TthHB5018_00830	COG1011	Hydrolase
TthHB5018_00840	COG0632	four-way junction helicase activity
TthHB5018_00850	COG1024	Enoyl-CoA hydratase
TthHB5018_00880	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHB5018_00900	COG1404	Belongs to the peptidase S8 family
TthHB5018_00940	COG0137	argininosuccinate synthase activity
TthHB5018_00950	COG0165	Argininosuccinate lyase
TthHB5018_00990	COG0505	Belongs to the CarA family
TthHB5018_01010	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthHB5018_01020	COG0166	Belongs to the GPI family
TthHB5018_01040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5018_01050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthHB5018_01060	COG0459	protein refolding
TthHB5018_01070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthHB5018_01080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthHB5018_01100	COG0778	Nitroreductase
TthHB5018_01110	COG0791	NLP P60 protein
TthHB5018_01110	COG1388	LysM domain
TthHB5018_01130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthHB5018_01140	COG2814	Major facilitator Superfamily
TthHB5018_01150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthHB5018_01160	COG0581	inorganic phosphate transmembrane transporter activity
TthHB5018_01170	COG0573	inorganic phosphate transmembrane transporter activity
TthHB5018_01180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthHB5018_01190	COG0482	sulfurtransferase activity
TthHB5018_01210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthHB5018_01220	COG0735	belongs to the Fur family
TthHB5018_01250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthHB5018_01270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthHB5018_01280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthHB5018_01290	COG0250	Participates in transcription elongation, termination and antitermination
TthHB5018_01310	COG0081	regulation of translation
TthHB5018_01330	COG0629	single-stranded DNA binding
TthHB5018_01340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthHB5018_01350	COG0359	binds to the 23S rRNA
TthHB5018_01360	COG0300	oxidoreductase activity
TthHB5018_01370	COG0321	lipoyl(octanoyl) transferase activity
TthHB5018_01380	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthHB5018_01440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthHB5018_01470	COG1598	PFAM Uncharacterised protein family UPF0150
TthHB5018_01480	COG0022	dehydrogenase e1 component
TthHB5018_01490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthHB5018_01500	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthHB5018_01550	COG2226	methyltransferase
TthHB5018_01560	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthHB5018_01580	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthHB5018_01590	COG1187	pseudouridine synthase activity
TthHB5018_01610	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthHB5018_01620	COG0686	Belongs to the AlaDH PNT family
TthHB5018_01640	COG1461	Dihydroxyacetone kinase
TthHB5018_01660	COG3583	domain protein
TthHB5018_01660	COG3584	3D domain protein
TthHB5018_01670	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthHB5018_01680	COG0222	ribosome binding
TthHB5018_01690	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthHB5018_01710	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthHB5018_01740	COG0697	spore germination
TthHB5018_01760	COG3177	Filamentation induced by cAMP protein fic
TthHB5018_01780	COG0243	molybdopterin cofactor binding
TthHB5018_01790	COG2272	Belongs to the type-B carboxylesterase lipase family
TthHB5018_01800	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthHB5018_01820	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHB5018_01850	COG0477	Major facilitator Superfamily
TthHB5018_01880	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthHB5018_01900	COG0105	UTP biosynthetic process
TthHB5018_01910	COG0631	protein serine/threonine phosphatase activity
TthHB5018_01920	COG0583	DNA-binding transcription factor activity
TthHB5018_01940	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHB5018_02010	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthHB5018_02030	COG1278	Cold shock
TthHB5018_02040	COG0484	heat shock protein binding
TthHB5018_02050	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthHB5018_02060	COG1968	undecaprenyl-diphosphatase activity
TthHB5018_02070	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthHB5018_02080	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthHB5018_02110	COG1309	transcriptional regulator
TthHB5018_02120	COG4242	Belongs to the peptidase S51 family
TthHB5018_02150	COG0802	atpase or kinase
TthHB5018_02160	COG0539	negative regulation of cytoplasmic translation
TthHB5018_02170	COG0495	leucyl-tRNA aminoacylation
TthHB5018_02210	COG1902	pentaerythritol trinitrate reductase activity
TthHB5018_02260	COG2414	aldehyde ferredoxin oxidoreductase
TthHB5018_02290	COG1187	pseudouridine synthase activity
TthHB5018_02310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHB5018_02320	COG0745	RESPONSE REGULATOR receiver
TthHB5018_02330	COG4191	Histidine kinase
TthHB5018_02340	COG0704	Plays a role in the regulation of phosphate uptake
TthHB5018_02350	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthHB5018_02370	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthHB5018_02390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthHB5018_02390	COG0515	serine threonine protein kinase
TthHB5018_02430	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthHB5018_02440	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_02470	COG0717	Belongs to the dCTP deaminase family
TthHB5018_02480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthHB5018_02490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthHB5018_02500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHB5018_02520	COG0583	DNA-binding transcription factor activity
TthHB5018_02530	COG3546	catalase activity
TthHB5018_02540	COG0758	DNA mediated transformation
TthHB5018_02540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHB5018_02550	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthHB5018_02570	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5018_02590	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthHB5018_02600	COG0442	prolyl-tRNA aminoacylation
TthHB5018_02630	COG2801	Transposase and inactivated derivatives
TthHB5018_02690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthHB5018_02730	COG0303	'Molybdopterin
TthHB5018_02740	COG0513	Belongs to the DEAD box helicase family
TthHB5018_02770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthHB5018_02800	COG2070	2-Nitropropane dioxygenase
TthHB5018_02830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthHB5018_02840	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHB5018_02850	COG0018	arginyl-trna synthetase
TthHB5018_02860	COG1007	ATP synthesis coupled electron transport
TthHB5018_02870	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5018_02880	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthHB5018_02890	COG0713	ATP synthesis coupled electron transport
TthHB5018_02900	COG0839	Belongs to the complex I subunit 6 family
TthHB5018_02910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5018_02920	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthHB5018_02930	COG1034	ATP synthesis coupled electron transport
TthHB5018_02940	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthHB5018_02950	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthHB5018_02960	COG0649	NAD binding
TthHB5018_02970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5018_02980	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5018_02990	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHB5018_03000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthHB5018_03020	COG4712	double-strand break repair protein
TthHB5018_03050	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthHB5018_03080	COG0135	phosphoribosylanthranilate isomerase activity
TthHB5018_03100	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthHB5018_03120	COG2720	vancomycin resistance protein
TthHB5018_03130	COG1126	abc transporter atp-binding protein
TthHB5018_03190	COG0277	FAD linked oxidase domain protein
TthHB5018_03210	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthHB5018_03220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthHB5018_03250	COG0314	molybdopterin synthase activity
TthHB5018_03260	COG1420	regulation of RNA biosynthetic process
TthHB5018_03270	COG0347	Belongs to the P(II) protein family
TthHB5018_03280	COG0004	ammonium transporteR
TthHB5018_03300	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthHB5018_03320	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHB5018_03350	COG1597	lipid kinase activity
TthHB5018_03380	COG0436	Aminotransferase
TthHB5018_03400	COG0475	glutathione-regulated potassium exporter activity
TthHB5018_03400	COG0569	domain protein
TthHB5018_03420	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthHB5018_03440	COG0277	FAD linked oxidase domain protein
TthHB5018_03520	COG2002	toxin-antitoxin pair type II binding
TthHB5018_03570	COG0667	Aldo Keto reductase
TthHB5018_03610	COG1067	ATP-dependent peptidase activity
TthHB5018_03620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthHB5018_03650	COG2105	PFAM AIG2 family protein
TthHB5018_03660	COG0297	glycogen (starch) synthase activity
TthHB5018_03680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthHB5018_03690	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthHB5018_03720	COG0142	geranyltranstransferase activity
TthHB5018_03740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthHB5018_03750	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_03760	COG0492	ferredoxin-NADP+ reductase activity
TthHB5018_03780	COG0792	nuclease activity
TthHB5018_03790	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthHB5018_03820	COG1175	transmembrane transport
TthHB5018_03830	COG0395	ABC-type sugar transport system, permease component
TthHB5018_03890	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthHB5018_03900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthHB5018_03910	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHB5018_03920	COG0805	protein transport
TthHB5018_03930	COG1605	Chorismate mutase
TthHB5018_03930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHB5018_04040	COG1063	alcohol dehydrogenase
TthHB5018_04100	COG2255	four-way junction helicase activity
TthHB5018_04110	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthHB5018_04120	COG0564	pseudouridine synthase activity
TthHB5018_04130	COG2801	Transposase and inactivated derivatives
TthHB5018_04190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthHB5018_04200	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthHB5018_04210	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthHB5018_04220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthHB5018_04240	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthHB5018_04250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthHB5018_04260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthHB5018_04330	COG0778	Nitroreductase
TthHB5018_04360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHB5018_04370	COG0131	Imidazoleglycerol-phosphate dehydratase
TthHB5018_04380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthHB5018_04390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthHB5018_04400	COG0517	IMP dehydrogenase activity
TthHB5018_04400	COG0516	GMP reductase activity
TthHB5018_04430	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthHB5018_04460	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHB5018_04500	COG0706	membrane insertase activity
TthHB5018_04510	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthHB5018_04520	COG0594	ribonuclease P activity
TthHB5018_04540	COG1022	Amp-dependent synthetase and ligase
TthHB5018_04590	COG1121	(ABC) transporter
TthHB5018_04600	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthHB5018_04610	COG1959	2 iron, 2 sulfur cluster binding
TthHB5018_04620	COG1104	cysteine desulfurase activity
TthHB5018_04630	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthHB5018_04640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthHB5018_04670	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_04710	COG0492	ferredoxin-NADP+ reductase activity
TthHB5018_04720	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_04720	COG3321	synthase
TthHB5018_04720	COG0604	alcohol dehydrogenase
TthHB5018_04730	COG0747	negative chemotaxis
TthHB5018_04740	COG0601	transmembrane transport
TthHB5018_04750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5018_04780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5018_04780	COG0517	IMP dehydrogenase activity
TthHB5018_04780	COG0617	tRNA 3'-terminal CCA addition
TthHB5018_04790	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHB5018_04800	COG2104	thiamine diphosphate biosynthetic process
TthHB5018_04810	COG0037	tRNA processing
TthHB5018_04840	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthHB5018_04860	COG0366	Alpha amylase catalytic
TthHB5018_04870	COG2226	methyltransferase
TthHB5018_04880	COG2226	methyltransferase
TthHB5018_04890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthHB5018_04910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthHB5018_04920	COG3744	PilT protein domain protein
TthHB5018_04940	COG0460	homoserine dehydrogenase
TthHB5018_04960	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthHB5018_05020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthHB5018_05080	COG0247	lactate metabolic process
TthHB5018_05090	COG0277	FAD linked oxidase domain protein
TthHB5018_05100	COG0277	FAD linked oxidase domain protein
TthHB5018_05110	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthHB5018_05120	COG1414	Transcriptional regulator
TthHB5018_05130	COG0789	Transcriptional regulator
TthHB5018_05150	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5018_05160	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHB5018_05230	COG0861	Integral membrane protein TerC family
TthHB5018_05240	COG2151	metal-sulfur cluster biosynthetic enzyme
TthHB5018_05250	COG0281	malic enzyme
TthHB5018_05280	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthHB5018_05290	COG0509	glycine decarboxylation via glycine cleavage system
TthHB5018_05300	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHB5018_05310	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHB5018_05320	COG0196	riboflavin kinase activity
TthHB5018_05370	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthHB5018_05380	COG2813	Specifically methylates the guanine in position
TthHB5018_05450	COG4956	integral membrane protein (PIN domain superfamily)
TthHB5018_05460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthHB5018_05470	COG0542	response to heat
TthHB5018_05480	COG0423	glycine-tRNA ligase activity
TthHB5018_05500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthHB5018_05540	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5018_05540	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHB5018_05560	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthHB5018_05580	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthHB5018_05600	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5018_05610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHB5018_05620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthHB5018_05630	COG0114	fumarate hydratase activity
TthHB5018_05640	COG0183	Belongs to the thiolase family
TthHB5018_05670	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthHB5018_05680	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthHB5018_05710	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthHB5018_05720	COG1254	Belongs to the acylphosphatase family
TthHB5018_05780	COG1063	alcohol dehydrogenase
TthHB5018_05790	COG2133	pyrroloquinoline quinone binding
TthHB5018_05810	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthHB5018_05820	COG0154	amidase activity
TthHB5018_05870	COG0572	uridine kinase
TthHB5018_05880	COG3842	ATPase activity
TthHB5018_05910	COG4475	Protein of unknown function (DUF436)
TthHB5018_06020	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHB5018_06030	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthHB5018_06040	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthHB5018_06070	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthHB5018_06080	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthHB5018_06090	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthHB5018_06100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthHB5018_06120	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5018_06150	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthHB5018_06160	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthHB5018_06170	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthHB5018_06190	COG3870	Protein conserved in bacteria
TthHB5018_06200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthHB5018_06220	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthHB5018_06230	COG0740	serine-type endopeptidase activity
TthHB5018_06240	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthHB5018_06250	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthHB5018_06260	COG1410	methionine synthase
TthHB5018_06260	COG0646	methionine synthase
TthHB5018_06280	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHB5018_06330	COG1692	metallophosphoesterase
TthHB5018_06340	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthHB5018_06350	COG1970	mechanosensitive ion channel activity
TthHB5018_06520	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TthHB5018_06540	COG0582	viral genome integration into host DNA
TthHB5018_06550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHB5018_06570	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthHB5018_06580	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthHB5018_06690	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TthHB5018_06730	COG2801	Transposase and inactivated derivatives
TthHB5018_06780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHB5018_06820	COG0489	protein tyrosine kinase activity
TthHB5018_06840	COG2264	protein methyltransferase activity
TthHB5018_06850	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthHB5018_06920	COG0574	Belongs to the PEP-utilizing enzyme family
TthHB5018_06920	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHB5018_06940	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthHB5018_06950	COG2046	Belongs to the sulfate adenylyltransferase family
TthHB5018_06970	COG0730	response to heat
TthHB5018_06980	COG0175	sulfate reduction
TthHB5018_06990	COG1648	precorrin-2 dehydrogenase activity
TthHB5018_06990	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5018_07000	COG1587	Uroporphyrinogen-III synthase
TthHB5018_07010	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthHB5018_07030	COG0352	thiamine-phosphate diphosphorylase activity
TthHB5018_07040	COG2104	thiamine diphosphate biosynthetic process
TthHB5018_07050	COG2022	thiamine diphosphate biosynthetic process
TthHB5018_07060	COG2022	thiamine diphosphate biosynthetic process
TthHB5018_07060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5018_07070	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthHB5018_07080	COG0477	Major facilitator Superfamily
TthHB5018_07090	COG0351	phosphomethylpyrimidine kinase
TthHB5018_07090	COG0352	thiamine-phosphate diphosphorylase activity
TthHB5018_07160	COG1175	transmembrane transport
TthHB5018_07180	COG1940	carbohydrate kinase activity
TthHB5018_07190	COG0183	Belongs to the thiolase family
TthHB5018_07220	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_07280	COG2030	dehydratase
TthHB5018_07300	COG0596	Alpha beta hydrolase
TthHB5018_07310	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5018_07340	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHB5018_07340	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHB5018_07360	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthHB5018_07380	COG0195	Participates in both transcription termination and antitermination
TthHB5018_07390	COG0779	Required for maturation of 30S ribosomal subunits
TthHB5018_07400	COG0739	heme binding
TthHB5018_07410	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthHB5018_07420	COG0640	Transcriptional regulator
TthHB5018_07430	COG2217	Heavy metal translocating P-type atpase
TthHB5018_07440	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthHB5018_07450	COG0017	Asparaginyl-tRNA synthetase
TthHB5018_07460	COG0561	phosphatase activity
TthHB5018_07470	COG0384	phenazine biosynthesis protein PhzF
TthHB5018_07490	COG0124	histidyl-tRNA synthetase
TthHB5018_07510	COG3842	ATPase activity
TthHB5018_07540	COG1573	uracil-dna glycosylase
TthHB5018_07580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthHB5018_07590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHB5018_07590	COG0519	Catalyzes the synthesis of GMP from XMP
TthHB5018_07610	COG1316	TRANSCRIPTIONal
TthHB5018_07620	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthHB5018_07710	COG0295	cytidine deaminase activity
TthHB5018_07730	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHB5018_07750	COG1760	l-serine dehydratase
TthHB5018_07770	COG0481	GTPase activity
TthHB5018_07790	COG0463	Glycosyl transferase, family 2
TthHB5018_07820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHB5018_07850	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_07900	COG0405	Gamma-glutamyltransferase
TthHB5018_07910	COG1073	alpha beta
TthHB5018_07950	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthHB5018_07960	COG2873	o-acetylhomoserine
TthHB5018_07990	COG1063	alcohol dehydrogenase
TthHB5018_08020	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHB5018_08040	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHB5018_08050	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHB5018_08060	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHB5018_08150	COG0167	dihydroorotate dehydrogenase activity
TthHB5018_08180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TthHB5018_08190	COG0540	Belongs to the ATCase OTCase family
TthHB5018_08200	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TthHB5018_08220	COG0730	response to heat
TthHB5018_08230	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthHB5018_08250	COG1960	acyl-CoA dehydrogenase activity
TthHB5018_08260	COG0456	acetyltransferase
TthHB5018_08280	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthHB5018_08290	COG0009	L-threonylcarbamoyladenylate synthase
TthHB5018_08300	COG1459	type II secretion system
TthHB5018_08330	COG0277	FAD linked oxidase domain protein
TthHB5018_08370	COG0287	Prephenate dehydrogenase
TthHB5018_08380	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHB5018_08390	COG2514	catechol 2,3-dioxygenase activity
TthHB5018_08400	COG2353	YceI-like domain
TthHB5018_08410	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHB5018_08420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHB5018_08460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5018_08470	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthHB5018_08490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthHB5018_08500	COG0151	Belongs to the GarS family
TthHB5018_08510	COG2176	DNA-directed DNA polymerase activity
TthHB5018_08510	COG5002	protein histidine kinase activity
TthHB5018_08570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthHB5018_08590	COG0217	transcriptional regulatory protein
TthHB5018_08600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthHB5018_08600	COG4651	solute:proton antiporter activity
TthHB5018_08610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthHB5018_08620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthHB5018_08630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHB5018_08640	COG1674	ftsk spoiiie
TthHB5018_08680	COG0517	IMP dehydrogenase activity
TthHB5018_08700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5018_08700	COG3620	sequence-specific DNA binding
TthHB5018_08700	COG0617	tRNA 3'-terminal CCA addition
TthHB5018_08720	COG1994	Peptidase M50
TthHB5018_08730	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthHB5018_08750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHB5018_08780	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHB5018_08800	COG2719	SpoVR family
TthHB5018_08810	COG2718	Belongs to the UPF0229 family
TthHB5018_08820	COG2766	serine protein kinase
TthHB5018_08870	COG2137	regulation of response to DNA damage stimulus
TthHB5018_08890	COG2359	stage V sporulation protein S
TthHB5018_08900	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHB5018_08910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthHB5018_08930	COG0463	Glycosyl transferase, family 2
TthHB5018_08940	COG0750	zinc metalloprotease
TthHB5018_08950	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthHB5018_08960	COG4589	Belongs to the CDS family
TthHB5018_08970	COG0233	cytoplasmic translational termination
TthHB5018_08980	COG0528	UMP kinase activity
TthHB5018_08990	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthHB5018_09000	COG0052	Belongs to the universal ribosomal protein uS2 family
TthHB5018_09010	COG0582	viral genome integration into host DNA
TthHB5018_09200	COG0535	radical SAM domain protein
TthHB5018_09280	COG2211	Major facilitator Superfamily
TthHB5018_09320	COG4966	pilus assembly protein PilW
TthHB5018_09360	COG2801	Transposase and inactivated derivatives
TthHB5018_09380	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TthHB5018_09380	COG2199	diguanylate cyclase activity
TthHB5018_09410	COG2801	Transposase and inactivated derivatives
TthHB5018_09450	COG2801	Transposase and inactivated derivatives
TthHB5018_09500	COG1525	nuclease
TthHB5018_09530	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthHB5018_09540	COG0494	nUDIX hydrolase
TthHB5018_09630	COG0402	S-adenosylhomocysteine deaminase activity
TthHB5018_09650	COG4948	Mandelate Racemase Muconate Lactonizing
TthHB5018_09660	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthHB5018_09670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHB5018_09680	COG1811	Na channel or pump
TthHB5018_09690	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5018_09690	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthHB5018_09720	COG1215	transferase activity, transferring glycosyl groups
TthHB5018_09740	COG1215	transferase activity, transferring glycosyl groups
TthHB5018_09760	COG0438	transferase activity, transferring glycosyl groups
TthHB5018_09770	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthHB5018_09800	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHB5018_09800	COG1024	Enoyl-CoA hydratase
TthHB5018_09810	COG0183	Belongs to the thiolase family
TthHB5018_09820	COG1960	acyl-CoA dehydrogenase activity
TthHB5018_09830	COG0215	cysteine-tRNA ligase activity
TthHB5018_09840	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthHB5018_09860	COG2738	Putative neutral zinc metallopeptidase
TthHB5018_09890	COG1196	nuclear chromosome segregation
TthHB5018_09930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthHB5018_09940	COG3153	acetyltransferase
TthHB5018_09940	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHB5018_09950	COG1268	BioY protein
TthHB5018_09970	COG0126	phosphoglycerate kinase activity
TthHB5018_09980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthHB5018_09990	COG0824	Thioesterase
TthHB5018_10010	COG0557	exoribonuclease II activity
TthHB5018_10030	COG1355	regulation of microtubule-based process
TthHB5018_10040	COG1353	crispr-associated protein
TthHB5018_10040	COG0617	tRNA 3'-terminal CCA addition
TthHB5018_10050	COG0237	dephospho-CoA kinase activity
TthHB5018_10070	COG0742	ribosomal rna small subunit methyltransferase
TthHB5018_10080	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthHB5018_10090	COG0138	bifunctional purine biosynthesis protein purh
TthHB5018_10100	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthHB5018_10130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthHB5018_10220	COG0149	triose-phosphate isomerase activity
TthHB5018_10230	COG3239	Fatty acid desaturase
TthHB5018_10240	COG1490	D-aminoacyl-tRNA deacylase activity
TthHB5018_10250	COG1307	EDD domain protein, DegV family
TthHB5018_10260	COG1307	EDD domain protein, DegV family
TthHB5018_10270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthHB5018_10280	COG1510	regulation of RNA biosynthetic process
TthHB5018_10300	COG3769	mannosylglycerate metabolic process
TthHB5018_10320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHB5018_10340	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_10350	COG2368	4-hydroxyphenylacetate
TthHB5018_10360	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthHB5018_10420	COG2050	protein possibly involved in aromatic compounds catabolism
TthHB5018_10430	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHB5018_10450	COG2030	dehydratase
TthHB5018_10450	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_10490	COG3396	Phenylacetate-CoA oxygenase
TthHB5018_10510	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthHB5018_10530	COG0395	ABC-type sugar transport system, permease component
TthHB5018_10570	COG1980	fructose-bisphosphate aldolase activity
TthHB5018_10580	COG1733	regulation of RNA biosynthetic process
TthHB5018_10590	COG2193	ferroxidase activity
TthHB5018_10600	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthHB5018_10610	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthHB5018_10630	COG1331	Highly conserved protein containing a thioredoxin domain
TthHB5018_10640	COG0183	Belongs to the thiolase family
TthHB5018_10650	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthHB5018_10710	COG0745	RESPONSE REGULATOR receiver
TthHB5018_10720	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_10740	COG0248	Ppx GppA phosphatase
TthHB5018_10750	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthHB5018_10800	COG0745	RESPONSE REGULATOR receiver
TthHB5018_10810	COG2205	protein histidine kinase activity
TthHB5018_10850	COG1136	(ABC) transporter
TthHB5018_10860	COG1136	(ABC) transporter
TthHB5018_10860	COG0577	efflux transmembrane transporter activity
TthHB5018_10960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthHB5018_11120	COG2897	thiosulfate sulfurtransferase activity
TthHB5018_11130	COG1760	l-serine dehydratase
TthHB5018_11140	COG2197	response regulator
TthHB5018_11150	COG0335	large ribosomal subunit rRNA binding
TthHB5018_11160	COG0336	Belongs to the RNA methyltransferase TrmD family
TthHB5018_11170	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthHB5018_11180	COG1837	Belongs to the UPF0109 family
TthHB5018_11190	COG0228	four-way junction DNA binding
TthHB5018_11220	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5018_11230	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5018_11230	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5018_11240	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthHB5018_11260	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthHB5018_11280	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthHB5018_11290	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthHB5018_11300	COG1702	phosphate starvation-inducible protein PhoH
TthHB5018_11320	COG4864	UPF0365 protein
TthHB5018_11340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthHB5018_11380	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5018_11380	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHB5018_11400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHB5018_11420	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthHB5018_11430	COG1397	ADP-ribosylglycohydrolase
TthHB5018_11440	COG2239	Acts as a magnesium transporter
TthHB5018_11460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHB5018_11460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHB5018_11480	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHB5018_11480	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHB5018_11490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthHB5018_11500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthHB5018_11510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthHB5018_11520	COG0006	proline dipeptidase activity
TthHB5018_11540	COG0739	heme binding
TthHB5018_11560	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthHB5018_11570	COG0254	rRNA binding
TthHB5018_11590	COG2001	Belongs to the MraZ family
TthHB5018_11600	COG0275	rRNA processing
TthHB5018_11620	COG0768	penicillin binding
TthHB5018_11630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthHB5018_11650	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHB5018_11660	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthHB5018_11670	COG0772	Belongs to the SEDS family
TthHB5018_11680	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthHB5018_11690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthHB5018_11700	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthHB5018_11740	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthHB5018_11760	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHB5018_11780	COG0159	tryptophan synthase activity
TthHB5018_11790	COG0133	tryptophan synthase activity
TthHB5018_11800	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthHB5018_11810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHB5018_11820	COG1744	ABC transporter substrate-binding protein PnrA-like
TthHB5018_11830	COG3845	ABC transporter
TthHB5018_11930	COG0438	transferase activity, transferring glycosyl groups
TthHB5018_11940	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHB5018_11960	COG0039	L-malate dehydrogenase activity
TthHB5018_11970	COG2819	hydrolase of the alpha beta superfamily
TthHB5018_11980	COG0861	Integral membrane protein TerC family
TthHB5018_12000	COG0247	lactate metabolic process
TthHB5018_12000	COG2181	nitrate reductase activity
TthHB5018_12020	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthHB5018_12030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthHB5018_12040	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthHB5018_12060	COG0439	Biotin carboxylase
TthHB5018_12070	COG0511	ligase activity, forming carbon-carbon bonds
TthHB5018_12080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthHB5018_12120	COG0010	Belongs to the arginase family
TthHB5018_12150	COG1100	Small GTP-binding protein
TthHB5018_12170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5018_12180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHB5018_12210	COG2814	Major facilitator Superfamily
TthHB5018_12220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthHB5018_12230	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHB5018_12240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthHB5018_12260	COG0745	RESPONSE REGULATOR receiver
TthHB5018_12270	COG5002	protein histidine kinase activity
TthHB5018_12280	COG1960	acyl-CoA dehydrogenase activity
TthHB5018_12290	COG2086	electron transfer activity
TthHB5018_12300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthHB5018_12320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHB5018_12330	COG1573	uracil-dna glycosylase
TthHB5018_12340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHB5018_12340	COG1796	DNA polymerase
TthHB5018_12370	COG2309	aminopeptidase activity
TthHB5018_12410	COG2873	o-acetylhomoserine
TthHB5018_12420	COG2358	TRAP transporter, solute receptor (TAXI family
TthHB5018_12460	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHB5018_12470	COG0134	indole-3-glycerol-phosphate synthase activity
TthHB5018_12480	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthHB5018_12500	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthHB5018_12530	COG0765	amino acid transport
TthHB5018_12540	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthHB5018_12560	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthHB5018_12570	COG0569	domain protein
TthHB5018_12580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5018_12590	COG1426	Protein conserved in bacteria
TthHB5018_12600	COG2313	pseudouridylate synthase activity
TthHB5018_12620	COG3001	Fructosamine kinase
TthHB5018_12630	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHB5018_12650	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthHB5018_12680	COG0012	GTP binding
TthHB5018_12690	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthHB5018_12710	COG0424	maF-like protein
TthHB5018_12740	COG0768	penicillin binding
TthHB5018_12760	COG2322	membrane
TthHB5018_12790	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthHB5018_12800	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHB5018_12820	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthHB5018_12850	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHB5018_12880	COG2801	Transposase and inactivated derivatives
TthHB5018_12910	COG2801	Transposase and inactivated derivatives
TthHB5018_12950	COG1131	(ABC) transporter
TthHB5018_12980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHB5018_13010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthHB5018_13020	COG0440	acetolactate synthase activity
TthHB5018_13030	COG0028	Belongs to the TPP enzyme family
TthHB5018_13040	COG0492	ferredoxin-NADP+ reductase activity
TthHB5018_13050	COG4970	Tfp pilus assembly protein FimT
TthHB5018_13100	COG2165	general secretion pathway protein
TthHB5018_13160	COG0180	Tryptophanyl-tRNA synthetase
TthHB5018_13170	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHB5018_13180	COG0066	3-isopropylmalate dehydratase activity
TthHB5018_13190	COG0473	3-isopropylmalate dehydrogenase activity
TthHB5018_13220	COG0300	oxidoreductase activity
TthHB5018_13230	COG0129	dihydroxy-acid dehydratase activity
TthHB5018_13250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthHB5018_13260	COG1177	transmembrane transport
TthHB5018_13270	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthHB5018_13280	COG3842	ATPase activity
TthHB5018_13290	COG0772	Belongs to the SEDS family
TthHB5018_13300	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthHB5018_13310	COG2894	cell division
TthHB5018_13320	COG1733	regulation of RNA biosynthetic process
TthHB5018_13340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5018_13340	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHB5018_13360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5018_13370	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5018_13380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5018_13390	COG0653	protein targeting
TthHB5018_13400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthHB5018_13440	COG0393	Putative heavy-metal-binding
TthHB5018_13450	COG1111	helicase
TthHB5018_13450	COG1205	dead DEAH box helicase
TthHB5018_13480	COG0358	DNA primase activity
TthHB5018_13500	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHB5018_13510	COG0697	spore germination
TthHB5018_13520	COG0612	Peptidase, M16
TthHB5018_13530	COG0612	Peptidase, M16
TthHB5018_13540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthHB5018_13590	COG1394	ATPase activity, coupled to movement of substances
TthHB5018_13600	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthHB5018_13610	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthHB5018_13620	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHB5018_13630	COG1527	subunit (C
TthHB5018_13640	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHB5018_13660	COG1269	ATP hydrolysis coupled proton transport
TthHB5018_13710	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHB5018_13730	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHB5018_13760	COG0419	ATPase involved in DNA repair
TthHB5018_13770	COG0420	3'-5' exonuclease activity
TthHB5018_13810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthHB5018_13820	COG2884	Cell division ATP-binding protein ftsE
TthHB5018_13830	COG0793	Belongs to the peptidase S41A family
TthHB5018_13850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5018_13850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHB5018_13860	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthHB5018_13870	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthHB5018_13890	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHB5018_13900	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHB5018_13910	COG1129	ABC transporter
TthHB5018_13920	COG0746	molybdenum cofactor guanylyltransferase activity
TthHB5018_13940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5018_13980	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthHB5018_13990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHB5018_14000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthHB5018_14020	COG1994	Peptidase M50
TthHB5018_14020	COG0517	IMP dehydrogenase activity
TthHB5018_14030	COG2358	TRAP transporter, solute receptor (TAXI family
TthHB5018_14050	COG2358	TRAP transporter, solute receptor (TAXI family
TthHB5018_14090	COG0788	formyltetrahydrofolate deformylase activity
TthHB5018_14100	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthHB5018_14110	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthHB5018_14120	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthHB5018_14160	COG0737	Belongs to the 5'-nucleotidase family
TthHB5018_14170	COG0174	glutamine synthetase
TthHB5018_14190	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHB5018_14230	COG0747	negative chemotaxis
TthHB5018_14240	COG0601	transmembrane transport
TthHB5018_14250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5018_14280	COG0285	dihydrofolate synthase activity
TthHB5018_14290	COG1132	(ABC) transporter
TthHB5018_14300	COG1132	(ABC) transporter
TthHB5018_14310	COG0372	Belongs to the citrate synthase family
TthHB5018_14320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthHB5018_14330	COG1482	cell wall glycoprotein biosynthetic process
TthHB5018_14350	COG1515	deoxyribonuclease V activity
TthHB5018_14370	COG0776	regulation of translation
TthHB5018_14400	COG2197	response regulator
TthHB5018_14430	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthHB5018_14440	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthHB5018_14450	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthHB5018_14460	COG1324	tolerance protein
TthHB5018_14490	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5018_14530	COG2205	protein histidine kinase activity
TthHB5018_14550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
TthHB5018_14610	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
TthHB5018_14620	COG0247	lactate metabolic process
TthHB5018_14630	COG1139	Iron-sulfur cluster binding protein
TthHB5018_14640	COG1556	Lactate utilization protein
TthHB5018_14660	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHB5018_14670	COG0515	serine threonine protein kinase
TthHB5018_14670	COG2815	serine threonine protein kinase
TthHB5018_14690	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthHB5018_14710	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthHB5018_14750	COG0473	3-isopropylmalate dehydrogenase activity
TthHB5018_14800	COG1450	Type ii and iii secretion system protein
TthHB5018_14810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthHB5018_14820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthHB5018_14830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthHB5018_14840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHB5018_14840	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthHB5018_14850	COG0736	holo-[acyl-carrier-protein] synthase activity
TthHB5018_14880	COG1160	GTP binding
TthHB5018_14890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthHB5018_14900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthHB5018_14900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthHB5018_14910	COG0083	homoserine kinase activity
TthHB5018_14930	COG0268	Binds directly to 16S ribosomal RNA
TthHB5018_14950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthHB5018_14960	COG0723	plastoquinol--plastocyanin reductase activity
TthHB5018_14980	COG4235	cytochrome complex assembly
TthHB5018_14980	COG3088	subunit of a heme lyase
TthHB5018_14990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHB5018_15000	COG1138	Cytochrome C-type biogenesis protein
TthHB5018_15010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthHB5018_15020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHB5018_15030	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHB5018_15040	COG4133	protoheme IX ABC transporter activity
TthHB5018_15050	COG0785	Cytochrome C biogenesis protein
TthHB5018_15060	COG3258	Cytochrome c
TthHB5018_15080	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHB5018_15110	COG3258	Cytochrome c
TthHB5018_15120	COG2010	Cytochrome c
TthHB5018_15130	COG0737	Belongs to the 5'-nucleotidase family
TthHB5018_15140	COG2010	Cytochrome c
TthHB5018_15150	COG3258	Cytochrome c
TthHB5018_15190	COG2010	Cytochrome c
TthHB5018_15200	COG3842	ATPase activity
TthHB5018_15260	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5018_15260	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5018_15270	COG3360	Dodecin
TthHB5018_15300	COG1024	Enoyl-CoA hydratase
TthHB5018_15310	COG0813	purine-nucleoside phosphorylase activity
TthHB5018_15320	COG1136	(ABC) transporter
TthHB5018_15330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5018_15340	COG2045	Belongs to the ComB family
TthHB5018_15360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthHB5018_15380	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthHB5018_15400	COG0107	imidazoleglycerol-phosphate synthase activity
TthHB5018_15410	COG0140	phosphoribosyl-ATP diphosphatase activity
TthHB5018_15410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthHB5018_15430	COG1494	fructose-1,6-bisphosphatase
TthHB5018_15440	COG0686	Belongs to the AlaDH PNT family
TthHB5018_15450	COG0427	acetyl-CoA hydrolase
TthHB5018_15460	COG0084	hydrolase, TatD family'
TthHB5018_15470	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthHB5018_15490	COG0017	Asparaginyl-tRNA synthetase
TthHB5018_15510	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthHB5018_15540	COG2009	succinate dehydrogenase
TthHB5018_15550	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHB5018_15610	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5018_15620	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthHB5018_15630	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthHB5018_15640	COG0504	CTP synthase activity
TthHB5018_15660	COG0067	glutamate synthase
TthHB5018_15660	COG0069	glutamate synthase activity
TthHB5018_15660	COG0070	glutamate synthase
TthHB5018_15680	COG0840	transmembrane signaling receptor activity
TthHB5018_15690	COG0305	Participates in initiation and elongation during chromosome replication
TthHB5018_15710	COG0475	glutathione-regulated potassium exporter activity
TthHB5018_15720	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHB5018_15720	COG0517	IMP dehydrogenase activity
TthHB5018_15720	COG0617	tRNA 3'-terminal CCA addition
TthHB5018_15750	COG0475	glutathione-regulated potassium exporter activity
TthHB5018_15760	COG0490	domain, Protein
TthHB5018_15800	COG3118	belongs to the thioredoxin family
TthHB5018_15860	COG0542	response to heat
TthHB5018_15870	COG0789	Transcriptional regulator
TthHB5018_15880	COG0484	heat shock protein binding
TthHB5018_15890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthHB5018_15900	COG0443	Heat shock 70 kDa protein
TthHB5018_15910	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthHB5018_15920	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthHB5018_15930	COG0616	signal peptide processing
TthHB5018_15940	COG1714	RDD family
TthHB5018_15960	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthHB5018_15970	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthHB5018_15980	COG0714	Associated with various cellular activities
TthHB5018_15990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHB5018_15990	COG0574	Belongs to the PEP-utilizing enzyme family
TthHB5018_16000	COG1272	protein, Hemolysin III
TthHB5018_16020	COG3850	Histidine kinase
TthHB5018_16020	COG5002	protein histidine kinase activity
TthHB5018_16050	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthHB5018_16080	COG1011	Hydrolase
TthHB5018_16120	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthHB5018_16150	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthHB5018_16170	COG0047	phosphoribosylformylglycinamidine synthase activity
TthHB5018_16190	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthHB5018_16200	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthHB5018_16210	COG0116	Belongs to the methyltransferase superfamily
TthHB5018_16240	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthHB5018_16250	COG0497	DNA recombination
TthHB5018_16270	COG0604	alcohol dehydrogenase
TthHB5018_16310	COG0585	pseudouridine synthase activity
TthHB5018_16340	COG0557	exoribonuclease II activity
TthHB5018_16350	COG0473	3-isopropylmalate dehydrogenase activity
TthHB5018_16370	COG4974	Belongs to the 'phage' integrase family
TthHB5018_16420	COG0590	tRNA wobble adenosine to inosine editing
TthHB5018_16420	COG0037	tRNA processing
TthHB5018_16460	COG2050	protein possibly involved in aromatic compounds catabolism
TthHB5018_16480	COG0322	excinuclease ABC activity
TthHB5018_16490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHB5018_16500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHB5018_16510	COG1854	S-ribosylhomocysteine lyase activity
TthHB5018_16520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHB5018_16520	COG0519	Catalyzes the synthesis of GMP from XMP
TthHB5018_16540	COG4274	PFAM GYD family protein
TthHB5018_16550	COG0346	lactoylglutathione lyase activity
TthHB5018_16560	COG0328	RNA-DNA hybrid ribonuclease activity
TthHB5018_16570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHB5018_16580	COG2095	MarC family integral membrane protein
TthHB5018_16590	COG1438	arginine binding
TthHB5018_16600	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthHB5018_16610	COG1758	RNA polymerase activity
TthHB5018_16620	COG0194	GDP metabolic process
TthHB5018_16640	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthHB5018_16650	COG2385	sporulation resulting in formation of a cellular spore
TthHB5018_16660	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthHB5018_16680	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHB5018_16760	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHB5018_16770	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHB5018_16780	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_16790	COG0506	proline dehydrogenase activity
TthHB5018_16880	COG0156	8-amino-7-oxononanoate synthase activity
TthHB5018_16890	COG0827	DNA restriction-modification system
TthHB5018_16890	COG0732	type I restriction modification DNA specificity domain
TthHB5018_16920	COG0187	DNA topoisomerase II activity
TthHB5018_16930	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthHB5018_16940	COG0193	aminoacyl-tRNA hydrolase activity
TthHB5018_16950	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthHB5018_17010	COG0515	serine threonine protein kinase
TthHB5018_17010	COG2815	serine threonine protein kinase
TthHB5018_17020	COG0631	protein serine/threonine phosphatase activity
TthHB5018_17040	COG2814	Major facilitator Superfamily
TthHB5018_17050	COG0113	porphobilinogen synthase activity
TthHB5018_17060	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthHB5018_17070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthHB5018_17120	COG4946	Tricorn protease homolog
TthHB5018_17120	COG0823	Involved in the tonB-independent uptake of proteins
TthHB5018_17120	COG1506	peptidase
TthHB5018_17130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthHB5018_17140	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthHB5018_17180	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthHB5018_17190	COG1011	Hydrolase
TthHB5018_17240	COG0537	adenosine 5'-monophosphoramidase activity
TthHB5018_17250	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHB5018_17260	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthHB5018_17270	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthHB5018_17280	COG0071	Belongs to the small heat shock protein (HSP20) family
TthHB5018_17290	COG2897	thiosulfate sulfurtransferase activity
TthHB5018_17300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHB5018_17320	COG1764	response to oxidative stress
TthHB5018_17370	COG3842	ATPase activity
TthHB5018_17380	COG0101	tRNA pseudouridine synthase activity
TthHB5018_17390	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHB5018_17400	COG0601	transmembrane transport
TthHB5018_17430	COG0006	proline dipeptidase activity
TthHB5018_17440	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHB5018_17470	COG1166	arginine decarboxylase activity
TthHB5018_17480	COG3706	GGDEF domain
TthHB5018_17490	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthHB5018_17500	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthHB5018_17510	COG1611	Belongs to the LOG family
TthHB5018_17520	COG1193	negative regulation of DNA recombination
TthHB5018_17570	COG2801	Transposase and inactivated derivatives
TthHB5018_17590	COG0366	Alpha amylase catalytic
TthHB5018_17660	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthHB5018_17670	COG0142	geranyltranstransferase activity
TthHB5018_17700	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthHB5018_17760	COG0203	ribosomal protein L17
TthHB5018_17770	COG0202	RNA polymerase activity
TthHB5018_17780	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthHB5018_17790	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthHB5018_17800	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthHB5018_17810	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthHB5018_17830	COG0563	adenylate kinase activity
TthHB5018_17840	COG0201	protein transport
TthHB5018_17890	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthHB5018_17900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthHB5018_17910	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthHB5018_17940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
TthHB5018_17960	COG0255	Belongs to the universal ribosomal protein uL29 family
TthHB5018_17970	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthHB5018_17980	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthHB5018_18000	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthHB5018_18010	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthHB5018_18020	COG0089	rRNA binding
TthHB5018_18030	COG0088	Forms part of the polypeptide exit tunnel
TthHB5018_18050	COG0051	transcription antitermination factor activity, RNA binding
TthHB5018_18080	COG0049	tRNA binding
TthHB5018_18110	COG0442	prolyl-tRNA aminoacylation
TthHB5018_18150	COG1115	amino acid carrier protein
TthHB5018_18190	COG1489	DNA binding
TthHB5018_18230	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthHB5018_18260	COG0432	Pfam Uncharacterised protein family UPF0047
TthHB5018_18270	COG3253	May function as heme-dependent peroxidase
TthHB5018_18280	COG0668	transmembrane transport
TthHB5018_18300	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthHB5018_18310	COG2217	Heavy metal translocating P-type atpase
TthHB5018_18350	COG0745	RESPONSE REGULATOR receiver
TthHB5018_18360	COG2205	protein histidine kinase activity
TthHB5018_18410	COG2226	methyltransferase
TthHB5018_18450	COG2132	Multicopper oxidase
TthHB5018_18500	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthHB5018_18510	COG0822	iron-sulfur transferase activity
TthHB5018_18550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthHB5018_18570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthHB5018_18580	COG0284	orotidine-5'-phosphate decarboxylase activity
TthHB5018_18600	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthHB5018_18620	COG0416	fatty acid biosynthetic process
TthHB5018_18630	COG3118	belongs to the thioredoxin family
TthHB5018_18640	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHB5018_18650	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthHB5018_18670	COG0438	transferase activity, transferring glycosyl groups
TthHB5018_18720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthHB5018_18750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHB5018_18760	COG3706	GGDEF domain
TthHB5018_18830	COG0437	4 iron, 4 sulfur cluster binding
TthHB5018_18860	COG0825	malonyl-CoA metabolic process
TthHB5018_18870	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthHB5018_18950	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthHB5018_19000	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthHB5018_19010	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthHB5018_19020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthHB5018_19030	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthHB5018_19090	COG0315	cyclic pyranopterin monophosphate synthase activity
TthHB5018_19110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthHB5018_19140	COG0477	Major facilitator Superfamily
TthHB5018_19150	COG1694	Mazg nucleotide pyrophosphohydrolase
TthHB5018_19160	COG1803	Methylglyoxal synthase
TthHB5018_19180	COG0301	tRNA thio-modification
TthHB5018_19190	COG0154	amidase activity
TthHB5018_19230	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthHB5018_19260	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthHB5018_19270	COG1607	acyl-coa hydrolase
TthHB5018_19290	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthHB5018_19300	COG4149	molybdate abc transporter
TthHB5018_19310	COG1840	ABC-type Fe3 transport system, periplasmic component
TthHB5018_19340	COG0235	Class ii aldolase
TthHB5018_19350	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthHB5018_19360	COG0085	RNA polymerase activity
TthHB5018_19380	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthHB5018_19390	COG1077	Cell shape determining protein MreB Mrl
TthHB5018_19400	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthHB5018_19400	COG1418	mRNA catabolic process
TthHB5018_19410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthHB5018_19420	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthHB5018_19430	COG1058	Belongs to the CinA family
TthHB5018_19430	COG1546	Belongs to the CinA family
TthHB5018_19440	COG0354	folic acid binding
TthHB5018_19470	COG4948	Mandelate Racemase Muconate Lactonizing
TthHB5018_19500	COG1175	transmembrane transport
TthHB5018_19520	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthHB5018_19540	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHB5018_19560	COG0577	efflux transmembrane transporter activity
TthHB5018_19560	COG1136	(ABC) transporter
TthHB5018_19570	COG4181	ATPase activity
TthHB5018_19580	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHB5018_19620	COG0396	ATPase activity
TthHB5018_19630	COG0719	Fe-S assembly protein
TthHB5018_19640	COG0719	Fe-S assembly protein
TthHB5018_19650	COG2146	nitrite reductase [NAD(P)H] activity
TthHB5018_19670	COG0512	Glutamine amidotransferase of anthranilate synthase
TthHB5018_19680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHB5018_19760	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHB5018_19770	COG2226	methyltransferase
TthHB5018_19780	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthHB5018_19790	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthHB5018_19820	COG1774	PSP1 C-terminal conserved region
TthHB5018_19830	COG0470	DNA polymerase III
TthHB5018_19870	COG0497	DNA recombination
TthHB5018_19950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthHB5018_19980	COG0302	gtp cyclohydrolase
TthHB5018_20020	COG1217	gtp-binding protein TYPA
TthHB5018_20040	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthHB5018_20060	COG0395	ABC-type sugar transport system, permease component
TthHB5018_20070	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthHB5018_20080	COG1131	(ABC) transporter
TthHB5018_20120	COG0556	nucleotide-excision repair
TthHB5018_20130	COG0497	DNA recombination
TthHB5018_20150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHB5018_20160	COG0445	tRNA wobble uridine modification
TthHB5018_20210	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthHB5018_20210	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHB5018_20220	COG1543	Belongs to the glycosyl hydrolase 57 family
TthHB5018_20230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHB5018_20240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHB5018_20250	COG0189	ligase activity
TthHB5018_20280	COG0066	3-isopropylmalate dehydratase activity
TthHB5018_20290	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHB5018_20300	COG1598	PFAM Uncharacterised protein family UPF0150
TthHB5018_20320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHB5018_20330	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthHB5018_20340	COG1960	acyl-CoA dehydrogenase activity
TthHB5018_20350	COG0163	prenyltransferase activity
TthHB5018_20410	COG4555	ABC transporter
TthHB5018_20430	COG2096	Adenosyltransferase
TthHB5018_20460	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthHB5018_20470	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthHB5018_20490	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthHB5018_20500	COG0723	plastoquinol--plastocyanin reductase activity
TthHB5018_20550	COG1653	transport
TthHB5018_20560	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthHB5018_20570	COG1960	acyl-CoA dehydrogenase activity
TthHB5018_20590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthHB5018_20630	COG0393	Putative heavy-metal-binding
TthHB5018_20650	COG3956	TIGRFAM MazG family protein
TthHB5018_20670	COG0693	protein deglycase activity
TthHB5018_20680	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHB5018_20700	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthHB5018_20710	COG1937	Protein conserved in bacteria
TthHB5018_20730	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthHB5018_20730	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthHB5018_20740	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthHB5018_20750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHB5018_20790	COG0205	6-phosphofructokinase activity
TthHB5018_20800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthHB5018_20820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthHB5018_20860	COG0658	competence protein
TthHB5018_20860	COG2333	competence protein COMEC
TthHB5018_20870	COG1475	DNA binding
TthHB5018_20880	COG1192	Involved in chromosome partitioning
TthHB5018_20890	COG0357	Ribosomal RNA small subunit methyltransferase G
TthHB5018_20900	COG0445	tRNA wobble uridine modification
TthHB5018_b20930	COG2801	Transposase and inactivated derivatives
TthHB5018_b20970	COG2211	Major facilitator Superfamily
TthHB5018_b21050	COG1337	RAMP superfamily
TthHB5018_b21080	COG2801	Transposase and inactivated derivatives
TthHB5018_b21140	COG2801	Transposase and inactivated derivatives
TthHB5018_b21170	COG1518	maintenance of DNA repeat elements
TthHB5018_b21180	COG2801	Transposase and inactivated derivatives
TthHB5018_b21200	COG1518	maintenance of DNA repeat elements
TthHB5018_b21240	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthHB5018_b21340	COG2801	Transposase and inactivated derivatives
TthHB5018_b21390	COG0411	ABC transporter
TthHB5018_b21400	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5018_b21450	COG1960	acyl-CoA dehydrogenase activity
TthHB5018_b21470	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_b21480	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_b21480	COG2030	dehydratase
TthHB5018_b21500	COG0318	PFAM AMP-dependent synthetase and ligase
TthHB5018_b21510	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_b21550	COG0588	phosphoglycerate mutase activity
TthHB5018_b21710	COG2801	Transposase and inactivated derivatives
TthHB5018_b21870	COG2329	Antibiotic biosynthesis monooxygenase
TthHB5018_b21890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHB5018_b21900	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthHB5018_b21920	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TthHB5018_b22020	COG1403	HNH endonuclease
TthHB5018_b22150	COG2181	nitrate reductase activity
TthHB5018_b22170	COG1140	nitrate reductase beta subunit
TthHB5018_b22180	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TthHB5018_b22210	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TthHB5018_b22220	COG2010	Cytochrome c
TthHB5018_b22250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5018_b22270	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TthHB5018_b22300	COG1252	NADH dehydrogenase
TthHB5018_b22310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthHB5018_b22330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthHB5018_b22360	COG2801	Transposase and inactivated derivatives
TthHB5018_b22380	COG2801	Transposase and inactivated derivatives
TthHB5018_b22430	COG2801	Transposase and inactivated derivatives
TthHB5018_b22500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthHB5018_b22530	COG2010	Cytochrome c
TthHB5018_b22540	COG0535	radical SAM domain protein
TthHB5018_b22560	COG2132	Multicopper oxidase
TthHB5018_b22570	COG2832	Protein of unknown function (DUF454)
TthHB5018_b22600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5018_b22800	COG0243	molybdopterin cofactor binding
TthHB5018_b22830	COG1192	Involved in chromosome partitioning
TthHB5018_b22840	COG1192	Involved in chromosome partitioning
TthHB5018_b22850	COG1475	DNA binding
TthHB5018_b22880	COG1475	DNA binding
TthHB5018_b22930	COG3345	alpha-galactosidase
TthHB5018_b22940	COG1085	galactose-1-phosphate uridylyltransferase
TthHB5018_b22980	COG1304	FMN binding
TthHB5018_b22990	COG1304	FMN binding
TthHB5018_b23030	COG1487	ribonuclease activity
TthHB5018_b23080	COG2124	cytochrome p450
TthHB5018_b23100	COG1562	ergosterol biosynthetic process
TthHB5018_b23120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5018_b23210	COG0702	epimerase
TthHB5018_b23320	COG2723	6-phospho-beta-galactosidase activity
TthHB5018_b23340	COG1175	transmembrane transport
TthHB5018_b23360	COG1609	Transcriptional regulator
TthHB5018_b23370	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_b23380	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_b23420	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_b23430	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHB5018_b23460	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthHB5018_b23470	COG0800	Aldolase
TthHB5018_b23490	COG1175	transmembrane transport
TthHB5018_b23500	COG0395	ABC-type sugar transport system, permease component
TthHB5018_b23580	COG1785	Belongs to the alkaline phosphatase family
TthHB5018_b23600	COG1492	cobalamin metabolic process
TthHB5018_b23610	COG1492	cobalamin metabolic process
TthHB5018_b23620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHB5018_b23650	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
TthHB5018_b23660	COG0778	Nitroreductase
TthHB5018_b23810	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthHB5018_b23860	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthHB5018_b23880	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TthHB5018_b23900	COG1797	cobyrinic acid a,c-diamide synthase activity
TthHB5018_c24060	COG1129	ABC transporter
TthHB5018_c24070	COG1879	ABC-type sugar transport system periplasmic component
TthHB5018_c24110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHB5018_c24190	COG1475	DNA binding
TthHB5018_c24200	COG1192	Involved in chromosome partitioning
TthHB5018_c24270	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_c24280	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthHB5018_c24290	COG1129	ABC transporter
TthHB5018_c24300	COG3962	Belongs to the TPP enzyme family
TthHB5018_c24320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthHB5018_c24340	COG0673	inositol 2-dehydrogenase activity
TthHB5018_c24350	COG3718	enzyme involved in inositol metabolism
TthHB5018_c24360	COG1349	DNA-binding transcription factor activity
TthHB5018_c24400	COG3842	ATPase activity
TthHB5018_c24450	COG3842	ATPase activity
TthHB5018_c24460	COG1175	transmembrane transport
TthHB5018_c24480	COG0395	ABC-type sugar transport system, permease component
TthHB5018_c24510	COG0434	BtpA family
TthHB5018_c24520	COG1349	DNA-binding transcription factor activity
TthHB5018_c24630	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TthHB5018_c24660	COG2002	toxin-antitoxin pair type II binding
TthHB5018_c24990	COG3335	DDE superfamily endonuclease
TthHB5018_c25010	COG1074	ATP-dependent DNA helicase activity
TthHB5018_c25040	COG1203	CRISPR-associated helicase, Cas3
TthHB5018_c25150	COG0300	oxidoreductase activity
TthHB5018_c25160	COG0673	inositol 2-dehydrogenase activity
TthHB5018_c25180	COG1070	Carbohydrate kinase
TthHB5018_c25210	COG1129	ABC transporter
TthHB5018_c25220	COG4214	carbohydrate transport
TthHB5018_c25230	COG4213	ABC transporter substrate-binding protein
TthHB5018_c25250	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthHB5018_c25260	COG4597	amino acid ABC transporter
TthHB5018_c25270	COG0765	amino acid transport
TthHB5018_c25280	COG1126	abc transporter atp-binding protein
TthHB5018_c25430	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_c25450	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_c25450	COG2030	dehydratase
TthHB5018_c25460	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
TthHB5018_c25470	COG0832	Belongs to the urease beta subunit family
TthHB5018_c25470	COG0804	urea catabolic process
TthHB5018_c25480	COG0183	Belongs to the thiolase family
TthHB5018_c25570	COG1012	belongs to the aldehyde dehydrogenase family
TthHB5018_c25580	COG1024	Enoyl-CoA hydratase
TthHB5018_c25590	COG1309	transcriptional regulator
TthHB5018_c25610	COG1024	Enoyl-CoA hydratase
TthHB5018_c25670	COG2801	Transposase and inactivated derivatives
TthHB5018_c25770	COG2801	Transposase and inactivated derivatives
TthHB5018_c25930	COG1172	Belongs to the binding-protein-dependent transport system permease family
TthHB5018_d25980	COG2211	Major facilitator Superfamily
TthHB5018_d26010	COG2801	Transposase and inactivated derivatives
TthHB5018_d26050	COG2801	Transposase and inactivated derivatives
TthHB5018_d26110	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthHB5018_d26140	COG2010	Cytochrome c
TthHB5018_d26150	COG0535	radical SAM domain protein
TthHB5018_d26160	COG2132	Multicopper oxidase
TthHB5018_d26170	COG2832	Protein of unknown function (DUF454)
TthHB5018_d26200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHB5018_d26360	COG0243	molybdopterin cofactor binding
TthHB5018_d26380	COG1192	Involved in chromosome partitioning
TthHB5018_d26390	COG1475	DNA binding
TthHB5018_d26420	COG1475	DNA binding
TthHB5018_d26450	COG3345	alpha-galactosidase
TthHB5018_d26460	COG1085	galactose-1-phosphate uridylyltransferase
TthHB5018_d26500	COG1304	FMN binding
TthHB5018_d26520	COG1487	ribonuclease activity
TthHB5018_d26570	COG2124	cytochrome p450
TthHB5018_d26590	COG1562	ergosterol biosynthetic process
TthHB5018_d26610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHB5018_d26670	COG0702	epimerase
TthHB5018_d26680	COG1233	COG1233 Phytoene dehydrogenase and related
TthHB5018_d26720	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHB5018_d26730	COG2723	6-phospho-beta-galactosidase activity
TthHB5018_d26750	COG1175	transmembrane transport
TthHB5018_d26780	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_d26810	COG1028	Short-chain dehydrogenase reductase Sdr
TthHB5018_d26820	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHB5018_d26840	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthHB5018_d26850	COG0800	Aldolase
TthHB5018_d26870	COG1175	transmembrane transport
TthHB5018_d26880	COG0395	ABC-type sugar transport system, permease component
TthHB5018_d26940	COG1785	Belongs to the alkaline phosphatase family
TthHB5018_d26950	COG1492	cobalamin metabolic process
TthHB5018_d26960	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHB5018_d27000	COG0778	Nitroreductase
TthHB5018_d27010	COG1648	precorrin-2 dehydrogenase activity
TthHB5018_d27010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHB5018_d27100	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthHB5018_d27110	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthHB5018_d27120	COG0588	phosphoglycerate mutase activity
TthHB5018_d27150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthHB5018_d27170	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TthHB5018_d27180	COG1797	cobyrinic acid a,c-diamide synthase activity
TthHB5018_e27300	COG2801	Transposase and inactivated derivatives
TthHB5018_t00340	COG0544	peptidyl-prolyl cis-trans isomerase activity