locus-tag class description COG0592 DNA-directed DNA polymerase activity COG0148 phosphopyruvate hydratase activity COG1007 ATP synthesis coupled electron transport COG1012 belongs to the aldehyde dehydrogenase family COG2030 dehydratase COG1012 belongs to the aldehyde dehydrogenase family COG2030 dehydratase COG3396 Phenylacetate-CoA oxygenase COG4973 Belongs to the 'phage' integrase family. XerC subfamily COG0395 ABC-type sugar transport system, permease component COG0018 arginyl-trna synthetase COG1980 fructose-bisphosphate aldolase activity COG1733 regulation of RNA biosynthetic process COG1733 regulation of RNA biosynthetic process COG2193 ferroxidase activity COG0029 Catalyzes the oxidation of L-aspartate to iminoaspartate COG0379 Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate COG1331 Highly conserved protein containing a thioredoxin domain COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG0183 Belongs to the thiolase family COG2049 5-oxoprolinase (ATP-hydrolyzing) activity COG1012 belongs to the aldehyde dehydrogenase family COG0769 Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan COG0855 Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) COG0745 RESPONSE REGULATOR receiver COG2205 protein histidine kinase activity COG0845 Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family COG1136 (ABC) transporter COG0577 efflux transmembrane transporter activity COG1136 (ABC) transporter COG1309 transcriptional regulator COG0553 Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair COG2070 2-Nitropropane dioxygenase COG0582 viral genome integration into host DNA COG2897 thiosulfate sulfurtransferase activity COG1760 l-serine dehydratase COG2197 response regulator COG0335 large ribosomal subunit rRNA binding COG0336 Belongs to the RNA methyltransferase TrmD family COG0806 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes COG1837 Belongs to the UPF0109 family COG0228 four-way junction DNA binding COG2185 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG1884 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG2185 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG1884 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG2185 Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly COG0053 Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family COG0782 Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus COG0818 Recycling of diacylglycerol produced during the turnover of membrane phospholipid COG0319 Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA COG1702 phosphate starvation-inducible protein PhoH COG4864 UPF0365 protein COG0169 Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) COG0258 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity COG0749 In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate COG0809 Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) COG1397 ADP-ribosylglycohydrolase COG2239 Acts as a magnesium transporter COG0108 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate COG0807 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate COG0117 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate COG1985 Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate COG1158 Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template COG0036 Belongs to the ribulose-phosphate 3-epimerase family COG0176 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway COG0060 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) COG0006 proline dipeptidase activity COG0739 heme binding COG0182 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) COG0254 rRNA binding COG2001 Belongs to the MraZ family COG0275 rRNA processing COG0768 penicillin binding COG0770 UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity COG0472 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan COG0771 Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) COG0772 Belongs to the SEDS family COG0707 Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) COG0773 UDP-N-acetylmuramate-L-alanine ligase activity COG0812 UDP-N-acetylmuramate dehydrogenase activity COG0817 Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group COG1060 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate COG0159 tryptophan synthase activity COG0133 tryptophan synthase activity COG1351 Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant COG0272 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA COG1744 ABC transporter substrate-binding protein PnrA-like COG3845 ABC transporter COG0513 Belongs to the DEAD box helicase family COG0438 transferase activity, transferring glycosyl groups COG0438 transferase activity, transferring glycosyl groups COG0466 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner COG0039 L-malate dehydrogenase activity COG2819 hydrolase of the alpha beta superfamily COG0861 Integral membrane protein TerC family COG0861 Integral membrane protein TerC family COG0303 'Molybdopterin COG0247 lactate metabolic process COG2181 nitrate reductase activity COG1963 PFAM Acid phosphatase vanadium-dependent haloperoxidase related COG0190 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate COG0781 Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons COG0439 Biotin carboxylase COG0511 ligase activity, forming carbon-carbon bonds COG0231 Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase COG0010 Belongs to the arginase family COG1100 Small GTP-binding protein COG1622 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor COG0843 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B COG2814 Major facilitator Superfamily COG0184 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome COG1185 polyribonucleotide nucleotidyltransferase activity COG0595 An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay COG0745 RESPONSE REGULATOR receiver COG5002 protein histidine kinase activity COG1960 acyl-CoA dehydrogenase activity COG1960 acyl-CoA dehydrogenase activity COG1960 acyl-CoA dehydrogenase activity COG1960 acyl-CoA dehydrogenase activity COG2086 electron transfer activity COG2025 fatty acid beta-oxidation using acyl-CoA dehydrogenase COG4799 Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta COG1573 uracil-dna glycosylase COG1387 Histidinol phosphatase and related hydrolases of the PHP family COG1796 DNA polymerase COG2309 aminopeptidase activity COG1135 Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system COG2873 o-acetylhomoserine COG2358 TRAP transporter, solute receptor (TAXI family COG2358 TRAP transporter, solute receptor (TAXI family COG1126 abc transporter atp-binding protein COG1752 Esterase of the alpha-beta hydrolase superfamily COG1752 Esterase of the alpha-beta hydrolase superfamily COG3311 Transcriptional regulator COG0134 indole-3-glycerol-phosphate synthase activity COG0106 1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase COG0442 prolyl-tRNA aminoacylation COG0608 single-stranded DNA 5'-3' exodeoxyribonuclease activity COG0765 amino acid transport COG0834 ABC-type amino acid transport signal transduction systems periplasmic component domain COG0168 Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA COG0569 domain protein COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG3635 2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity COG1426 Protein conserved in bacteria COG2313 pseudouridylate synthase activity COG3001 Fructosamine kinase COG0394 Belongs to the low molecular weight phosphotyrosine protein phosphatase family COG0565 Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA COG0012 GTP binding COG0274 Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate COG0424 maF-like protein COG0768 penicillin binding COG2322 membrane COG0618 3'(2'),5'-bisphosphate nucleotidase activity COG1364 Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate COG0002 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde COG0078 Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline COG0344 acyl-phosphate glycerol-3-phosphate acyltransferase activity COG1131 (ABC) transporter COG0119 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) COG0059 Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate COG0440 acetolactate synthase activity COG0028 Belongs to the TPP enzyme family COG0492 ferredoxin-NADP+ reductase activity COG4970 Tfp pilus assembly protein FimT COG2165 general secretion pathway protein COG1159 An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism COG0180 Tryptophanyl-tRNA synthetase COG0544 peptidyl-prolyl cis-trans isomerase activity COG0065 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate COG0066 3-isopropylmalate dehydratase activity COG0473 3-isopropylmalate dehydrogenase activity COG0300 oxidoreductase activity COG0272 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA COG0758 DNA mediated transformation COG0129 dihydroxy-acid dehydratase activity COG0687 Required for the activity of the bacterial periplasmic transport system of putrescine COG0687 Required for the activity of the bacterial periplasmic transport system of putrescine COG1177 transmembrane transport COG1176 ABC-type spermidine putrescine transport system, permease component I COG3842 ATPase activity COG0772 Belongs to the SEDS family COG0851 Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell COG2894 cell division COG3546 catalase activity COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG0365 Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA COG0653 protein targeting COG0533 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction COG0583 DNA-binding transcription factor activity COG0393 Putative heavy-metal-binding COG1111 helicase COG1205 dead DEAH box helicase COG0358 DNA primase activity COG1250 3-hydroxyacyl-CoA dehydrogenase COG0697 spore germination COG2896 Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate COG0612 Peptidase, M16 COG0612 Peptidase, M16 COG1200 Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) COG1394 ATPase activity, coupled to movement of substances COG1156 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit COG1155 Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit COG1436 Produces ATP from ADP in the presence of a proton gradient across the membrane COG1527 subunit (C COG1390 Produces ATP from ADP in the presence of a proton gradient across the membrane COG1269 ATP hydrolysis coupled proton transport COG2220 Zn-dependent hydrolases of the beta-lactamase fold COG0419 ATPase involved in DNA repair COG0420 3'-5' exonuclease activity COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family COG1544 Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase COG2884 Cell division ATP-binding protein ftsE COG0793 Belongs to the peptidase S41A family COG0073 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0143 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG0120 Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate COG1225 Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen COG1079 Belongs to the binding-protein-dependent transport system permease family COG1079 Belongs to the binding-protein-dependent transport system permease family COG4603 Belongs to the binding-protein-dependent transport system permease family COG4603 Belongs to the binding-protein-dependent transport system permease family COG0040 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity COG1129 ABC transporter COG0746 molybdenum cofactor guanylyltransferase activity COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG0035 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate COG0472 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan COG3705 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine COG0381 UDP-N-acetylglucosamine 2-epimerase activity COG0517 IMP dehydrogenase activity COG1994 Peptidase M50 COG0788 formyltetrahydrofolate deformylase activity COG0684 Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions COG0323 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex COG0717 Belongs to the dCTP deaminase family COG0249 that it carries out the mismatch recognition step. This protein has a weak ATPase activity COG0737 Belongs to the 5'-nucleotidase family COG0737 Belongs to the 5'-nucleotidase family COG0174 glutamine synthetase COG0559 Belongs to the binding-protein-dependent transport system permease family COG0747 negative chemotaxis COG0601 transmembrane transport COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components COG0285 dihydrofolate synthase activity COG1132 (ABC) transporter COG1132 (ABC) transporter COG0372 Belongs to the citrate synthase family COG0476 Involved in molybdopterin and thiamine biosynthesis, family 2 COG1482 cell wall glycoprotein biosynthetic process COG1515 deoxyribonuclease V activity COG0776 regulation of translation COG2197 response regulator COG2265 Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family COG1028 Short-chain dehydrogenase reductase Sdr COG0757 Catalyzes a trans-dehydration via an enolate intermediate COG0188 A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner COG1324 tolerance protein COG0664 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein COG2205 protein histidine kinase activity COG1327 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes COG0247 lactate metabolic process COG1139 Iron-sulfur cluster binding protein COG1556 Lactate utilization protein COG0515 serine threonine protein kinase COG2815 serine threonine protein kinase COG0860 N-Acetylmuramoyl-L-alanine amidase COG1521 Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis COG0473 3-isopropylmalate dehydrogenase activity COG1450 Type ii and iii secretion system protein COG0082 Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system COG0703 Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate COG0337 Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) COG0144 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA COG3270 Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA COG0736 holo-[acyl-carrier-protein] synthase activity COG1160 GTP binding COG0846 NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form COG0062 Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration COG0063 ADP-dependent NAD(P)H-hydrate dehydratase activity COG0083 homoserine kinase activity COG0268 Binds directly to 16S ribosomal RNA COG0162 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) COG0723 plastoquinol--plastocyanin reductase activity COG3088 subunit of a heme lyase COG4235 cytochrome complex assembly COG0526 COG0526, thiol-disulfide isomerase and thioredoxins COG0526 COG0526, thiol-disulfide isomerase and thioredoxins COG1138 Cytochrome C-type biogenesis protein COG2332 Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH COG0755 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes COG2386 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes COG4133 protoheme IX ABC transporter activity COG0785 Cytochrome C biogenesis protein COG3258 Cytochrome c COG0515 serine threonine protein kinase COG1520 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane COG0446 pyridine nucleotide-disulphide oxidoreductase COG3258 Cytochrome c COG3258 Cytochrome c COG2010 Cytochrome c COG2010 Cytochrome c COG2010 Cytochrome c COG3842 ATPase activity COG0318 PFAM AMP-dependent synthetase and ligase COG0318 PFAM AMP-dependent synthetase and ligase COG3360 Dodecin COG0766 Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine COG1024 Enoyl-CoA hydratase COG0813 purine-nucleoside phosphorylase activity COG1136 (ABC) transporter COG0664 - Catabolite gene activator and regulatory subunit of cAMP-dependent protein COG2045 Belongs to the ComB family COG0178 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate COG1206 Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs COG0107 imidazoleglycerol-phosphate synthase activity COG0139 Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP COG0140 phosphoribosyl-ATP diphosphatase activity COG1494 fructose-1,6-bisphosphatase COG0686 Belongs to the AlaDH PNT family COG0427 acetyl-CoA hydrolase COG0084 hydrolase, TatD family' COG1502 Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol COG1186 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA COG0017 Asparaginyl-tRNA synthetase COG0479 Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family COG2009 succinate dehydrogenase COG1586 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine COG0142 geranyltranstransferase activity COG0142 geranyltranstransferase activity COG0704 Plays a role in the regulation of phosphate uptake COG0103 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) COG0102 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly COG0504 CTP synthase activity COG0067 glutamate synthase COG0069 glutamate synthase activity COG0070 glutamate synthase COG0840 transmembrane signaling receptor activity COG0305 Participates in initiation and elongation during chromosome replication COG4191 Histidine kinase COG0475 glutathione-regulated potassium exporter activity COG0517 IMP dehydrogenase activity COG0617 tRNA 3'-terminal CCA addition COG0618 3'(2'),5'-bisphosphate nucleotidase activity COG0475 glutathione-regulated potassium exporter activity COG0490 domain, Protein COG0745 RESPONSE REGULATOR receiver COG3118 belongs to the thioredoxin family COG0542 response to heat COG0789 Transcriptional regulator COG0484 heat shock protein binding COG0576 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ COG0013 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain COG0443 Heat shock 70 kDa protein COG0465 Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins COG1092 Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA COG0616 signal peptide processing COG1310 metal-dependent protease of the Pad1 Jab1 superfamily COG0480 Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome COG0714 Associated with various cellular activities COG0574 Belongs to the PEP-utilizing enzyme family COG1080 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) COG1272 protein, Hemolysin III COG3850 Histidine kinase COG5002 protein histidine kinase activity COG0373 Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) COG1011 Hydrolase COG1011 Hydrolase COG1011 Hydrolase COG1187 pseudouridine synthase activity COG0015 Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily COG0152 phosphoribosylaminoimidazolesuccinocarboxamide synthase activity COG0047 phosphoribosylformylglycinamidine synthase activity COG0046 Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL COG0034 Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine COG0116 Belongs to the methyltransferase superfamily COG0112 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism COG0497 DNA recombination COG0604 alcohol dehydrogenase COG0585 pseudouridine synthase activity COG0557 exoribonuclease II activity COG0473 3-isopropylmalate dehydrogenase activity COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity COG4974 Belongs to the 'phage' integrase family COG0037 tRNA processing COG0590 tRNA wobble adenosine to inosine editing COG2050 protein possibly involved in aromatic compounds catabolism COG0322 excinuclease ABC activity COG2414 aldehyde ferredoxin oxidoreductase COG0462 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) COG0775 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively COG1854 S-ribosylhomocysteine lyase activity COG0518 GMP synthase (glutamine-hydrolyzing) activity COG0519 Catalyzes the synthesis of GMP from XMP COG4636 protein conserved in cyanobacteria COG4274 PFAM GYD family protein COG0346 lactoylglutathione lyase activity COG0328 RNA-DNA hybrid ribonuclease activity COG4799 Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta COG2095 MarC family integral membrane protein COG1438 arginine binding COG0452 Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine COG1758 RNA polymerase activity COG0194 GDP metabolic process COG0350 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated COG2385 sporulation resulting in formation of a cellular spore COG4365 Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH COG2107 Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) COG0334 Belongs to the Glu Leu Phe Val dehydrogenases family COG0334 Belongs to the Glu Leu Phe Val dehydrogenases family COG1012 belongs to the aldehyde dehydrogenase family COG0506 proline dehydrogenase activity COG0156 8-amino-7-oxononanoate synthase activity COG0732 type I restriction modification DNA specificity domain COG0827 DNA restriction-modification system COG0187 DNA topoisomerase II activity COG1181 Belongs to the D-alanine--D-alanine ligase family COG0193 aminoacyl-tRNA hydrolase activity COG1825 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance COG0515 serine threonine protein kinase COG2815 serine threonine protein kinase COG0631 protein serine/threonine phosphatase activity COG0631 protein serine/threonine phosphatase activity COG2814 Major facilitator Superfamily COG0113 porphobilinogen synthase activity COG1902 pentaerythritol trinitrate reductase activity COG0718 Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection COG0353 May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO COG0823 Involved in the tonB-independent uptake of proteins COG1506 peptidase COG4946 Tricorn protease homolog COG0327 Belongs to the GTP cyclohydrolase I type 2 NIF3 family COG0125 Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis COG0212 Belongs to the 5-formyltetrahydrofolate cyclo-ligase family COG0537 adenosine 5'-monophosphoramidase activity COG0621 Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine COG0220 tRNA (guanine-N7-)-methyltransferase activity COG1168 Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities COG0071 Belongs to the small heat shock protein (HSP20) family COG2897 thiosulfate sulfurtransferase activity COG0491 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid COG1764 response to oxidative stress COG3842 ATPase activity COG0101 tRNA pseudouridine synthase activity COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components COG0601 transmembrane transport COG0601 transmembrane transport COG0747 negative chemotaxis COG0006 proline dipeptidase activity COG0462 Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) COG0495 leucyl-tRNA aminoacylation COG1166 arginine decarboxylase activity COG3706 GGDEF domain COG0192 Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme COG0796 Provides the (R)-glutamate required for cell wall biosynthesis COG1611 Belongs to the LOG family COG1193 negative regulation of DNA recombination COG0366 Alpha amylase catalytic COG0539 negative regulation of cytoplasmic translation COG0127 Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions COG2344 Modulates transcription in response to changes in cellular NADH NAD( ) redox state COG0761 Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis COG0203 ribosomal protein L17 COG0202 RNA polymerase activity COG0522 One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit COG0100 Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome COG0099 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits COG0802 atpase or kinase COG0361 One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex COG0563 adenylate kinase activity COG0201 protein transport COG0097 This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center COG0096 One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit COG0199 Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site COG0093 Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome COG0186 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA COG0255 Belongs to the universal ribosomal protein uL29 family COG0197 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs COG0092 Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation COG0185 Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA COG0090 One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity COG0089 rRNA binding COG0088 Forms part of the polypeptide exit tunnel COG0051 transcription antitermination factor activity, RNA binding COG0049 tRNA binding COG4242 Belongs to the peptidase S51 family COG0442 prolyl-tRNA aminoacylation COG1115 amino acid carrier protein COG1489 DNA binding COG1309 transcriptional regulator COG1180 Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine COG0432 Pfam Uncharacterised protein family UPF0047 COG3253 May function as heme-dependent peroxidase COG0668 transmembrane transport COG0317 In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance COG2217 Heavy metal translocating P-type atpase COG0745 RESPONSE REGULATOR receiver COG2205 protein histidine kinase activity COG2226 methyltransferase COG0520 Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine COG0822 iron-sulfur transferase activity COG1947 Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol COG0240 glycerol-3-phosphate dehydrogenase [NAD(P)+] activity COG0461 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) COG0284 orotidine-5'-phosphate decarboxylase activity COG2120 A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics COG1211 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity COG0416 fatty acid biosynthetic process COG3118 belongs to the thioredoxin family COG1185 polyribonucleotide nucleotidyltransferase activity COG0801 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase COG0438 transferase activity, transferring glycosyl groups COG4992 N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity COG0042 Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines COG1968 undecaprenyl-diphosphatase activity COG0624 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls COG3706 GGDEF domain COG0437 4 iron, 4 sulfur cluster binding COG0075 2-aminoethylphosphonate-pyruvate transaminase activity COG0825 malonyl-CoA metabolic process COG0777 Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA COG0414 Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate COG0484 heat shock protein binding COG1057 Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) COG0536 An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control COG0211 Belongs to the bacterial ribosomal protein bL27 family COG0261 This protein binds to 23S rRNA in the presence of protein L20 COG1278 Cold shock COG1278 Cold shock COG0315 cyclic pyranopterin monophosphate synthase activity COG0245 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity COG1694 Mazg nucleotide pyrophosphohydrolase COG1803 Methylglyoxal synthase COG0301 tRNA thio-modification COG0154 amidase activity COG1055 Involved in arsenical resistance. Thought to form the channel of an arsenite pump COG1146 Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions COG2154 pterin-4-alpha-carbinolamine dehydratase COG1607 acyl-coa hydrolase COG0266 class I DNA-(apurinic or apyrimidinic site) endonuclease activity COG4149 molybdate abc transporter COG1840 ABC-type Fe3 transport system, periplasmic component COG0235 Class ii aldolase COG0086 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates COG0085 RNA polymerase activity COG0764 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity COG1077 Cell shape determining protein MreB Mrl COG0711 Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) COG1418 mRNA catabolic process COG0468 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage COG1514 Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester COG1058 Belongs to the CinA family COG1546 Belongs to the CinA family COG0354 folic acid binding COG4948 Mandelate Racemase Muconate Lactonizing COG1175 transmembrane transport COG0816 Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA COG0013 Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain COG0577 efflux transmembrane transporter activity COG1136 (ABC) transporter COG4181 ATPase activity COG0446 pyridine nucleotide-disulphide oxidoreductase COG0396 ATPase activity COG0719 Fe-S assembly protein COG0719 Fe-S assembly protein COG2146 nitrite reductase [NAD(P)H] activity COG0512 Glutamine amidotransferase of anthranilate synthase COG0147 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia COG0147 Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia COG0394 Belongs to the low molecular weight phosphotyrosine protein phosphatase family COG2226 methyltransferase COG1774 PSP1 C-terminal conserved region COG0470 DNA polymerase III COG0497 DNA recombination COG0497 DNA recombination COG0508 dehydrogenase complex catalyzes the overall conversion of COG0441 Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) COG0302 gtp cyclohydrolase COG1217 gtp-binding protein TYPA COG2256 atpase related to the helicase subunit of the holliday junction resolvase COG0395 ABC-type sugar transport system, permease component COG1804 L-carnitine dehydratase bile acid-inducible protein F COG1131 (ABC) transporter COG0556 nucleotide-excision repair COG0583 DNA-binding transcription factor activity COG0449 glutamine-fructose-6-phosphate transaminase (isomerizing) activity COG0445 tRNA wobble uridine modification COG0171 NAD+ synthase (glutamine-hydrolyzing) activity COG0388 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source COG1543 Belongs to the glycosyl hydrolase 57 family COG0548 Belongs to the acetylglutamate kinase family. ArgB subfamily COG0002 Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde COG0189 ligase activity COG0066 3-isopropylmalate dehydratase activity COG0065 Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate COG0105 UTP biosynthetic process COG0119 Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) COG0020 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids COG1960 acyl-CoA dehydrogenase activity COG0163 prenyltransferase activity COG4555 ABC transporter COG2096 Adenosyltransferase COG0263 Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate COG1539 Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin COG0014 Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate COG1290 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis COG0723 plastoquinol--plastocyanin reductase activity COG1653 transport COG0820 rRNA (adenine-C2-)-methyltransferase activity COG0216 Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA COG0393 Putative heavy-metal-binding COG3956 TIGRFAM MazG family protein COG1443 Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) COG0469 pyruvate kinase activity COG0297 glycogen (starch) synthase activity COG0548 Belongs to the acetylglutamate kinase family. ArgB subfamily COG2812 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity COG1937 Protein conserved in bacteria COG0674 pyruvate-flavodoxin oxidoreductase activity COG1014 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin COG1013 pyruvate-flavodoxin oxidoreductase activity COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity COG0477 Major facilitator Superfamily COG0205 6-phosphofructokinase activity COG0313 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA COG0221 Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions COG0658 competence protein COG2333 competence protein COMEC COG1475 DNA binding COG1192 Involved in chromosome partitioning COG0357 Ribosomal RNA small subunit methyltransferase G COG0445 tRNA wobble uridine modification COG0593 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids COG4663 Part of the tripartite ATP-independent periplasmic (TRAP) transport system COG4663 Part of the tripartite ATP-independent periplasmic (TRAP) transport system COG0164 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids COG2272 Belongs to the type-B carboxylesterase lipase family COG0243 molybdopterin cofactor binding COG2105 PFAM AIG2 family protein COG3177 Filamentation induced by cAMP protein fic COG0697 spore germination COG3288 NAD(P)+ transhydrogenase (AB-specific) activity COG0244 Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors COG0222 ribosome binding COG4591 ABC-type transport system involved in lipoprotein release permease component COG0745 RESPONSE REGULATOR receiver COG3583 domain protein COG3584 3D domain protein COG1461 Dihydroxyacetone kinase COG0686 Belongs to the AlaDH PNT family COG0130 Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs COG1187 pseudouridine synthase activity COG0634 Belongs to the purine pyrimidine phosphoribosyltransferase family COG0104 Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP COG2226 methyltransferase COG1576 Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA COG1071 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor COG0022 dehydrogenase e1 component COG1598 PFAM Uncharacterised protein family UPF0150 COG0448 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans COG1249 Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family COG0320 Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives COG0321 lipoyl(octanoyl) transferase activity COG0300 oxidoreductase activity COG1067 ATP-dependent peptidase activity COG0359 binds to the 23S rRNA COG0238 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit COG0629 single-stranded DNA binding COG0081 regulation of translation COG0250 Participates in transcription elongation, termination and antitermination COG0690 P-P-bond-hydrolysis-driven protein transmembrane transporter activity COG0267 Belongs to the bacterial ribosomal protein bL33 family COG0050 This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis COG1236 Exonuclease of the beta-lactamase fold involved in RNA processing COG0735 belongs to the Fur family COG0260 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides COG0482 sulfurtransferase activity COG0226 Part of the ABC transporter complex PstSACB involved in phosphate import COG0573 inorganic phosphate transmembrane transporter activity COG0581 inorganic phosphate transmembrane transporter activity COG1117 ATPase-coupled phosphate ion transmembrane transporter activity COG1195 it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP COG0791 NLP P60 protein COG1388 LysM domain COG0778 Nitroreductase COG1989 Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue COG2317 Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues COG0459 protein refolding COG0234 Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family COG0667 Aldo Keto reductase COG0166 Belongs to the GPI family COG1866 Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA COG0505 Belongs to the CarA family COG0165 Argininosuccinate lyase COG0137 argininosuccinate synthase activity COG1404 Belongs to the peptidase S8 family COG0508 dehydrogenase complex catalyzes the overall conversion of COG1024 Enoyl-CoA hydratase COG0632 four-way junction helicase activity COG1611 Belongs to the LOG family COG0566 Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family COG0624 Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls COG1940 carbohydrate kinase activity COG0623 enoyl-[acyl-carrier-protein] reductase (NADH) activity COG0821 Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate COG0343 queuine tRNA-ribosyltransferase activity COG0109 protoheme IX farnesyltransferase activity COG1612 heme a metabolic process COG1622 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor COG2010 Cytochrome c COG0843 Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B COG1845 cytochrome c oxidase, subunit III COG0391 Required for morphogenesis under gluconeogenic growth conditions COG1660 Displays ATPase and GTPase activities COG0223 Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus COG1624 Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria COG2002 toxin-antitoxin pair type II binding COG1015 Phosphotransfer between the C1 and C5 carbon atoms of pentose COG0685 methylenetetrahydrofolate reductase (NAD(P)H) activity COG1335 isochorismatase COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase COG1387 Histidinol phosphatase and related hydrolases of the PHP family COG2041 Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide COG1993 acr, cog1993 COG0239 Important for reducing fluoride concentration in the cell, thus reducing its toxicity COG0054 6,7-dimethyl-8-ribityllumazine synthase activity COG0521 Mo-molybdopterin cofactor biosynthetic process COG0436 Aminotransferase COG0285 dihydrofolate synthase activity COG0181 hydroxymethylbilane synthase activity COG0031 Belongs to the cysteine synthase cystathionine beta- synthase family COG1950 PFAM Membrane protein of COG0517 IMP dehydrogenase activity COG0794 Belongs to the SIS family. GutQ KpsF subfamily COG0033 Phosphoglucomutase COG1653 transport COG0496 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates COG0496 Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates COG1496 oxidoreductase activity COG2179 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668 COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB COG0064 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) COG0150 phosphoribosylformylglycinamidine cyclo-ligase activity COG0406 alpha-ribazole phosphatase activity COG1028 Short-chain dehydrogenase reductase Sdr COG0492 ferredoxin-NADP+ reductase activity COG0792 nuclease activity COG0043 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity COG1175 transmembrane transport COG0395 ABC-type sugar transport system, permease component COG0491 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid COG0682 Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins COG1207 Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain COG1826 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes COG0805 protein transport COG1605 Chorismate mutase COG2876 3-deoxy-7-phosphoheptulonate synthase activity COG3573 Dehydrogenase COG0277 FAD linked oxidase domain protein COG0277 FAD linked oxidase domain protein COG0277 FAD linked oxidase domain protein COG1063 alcohol dehydrogenase COG2255 four-way junction helicase activity COG0413 3-methyl-2-oxobutanoate hydroxymethyltransferase activity COG0564 pseudouridine synthase activity COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs COG0232 Belongs to the dGTPase family. Type 2 subfamily COG0304 beta-ketoacyl-acyl-carrier-protein synthase II activity COG0236 Carrier of the growing fatty acid chain in fatty acid biosynthesis COG0331 [acyl-carrier-protein] S-malonyltransferase activity COG0332 Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids COG0333 Belongs to the bacterial ribosomal protein bL32 family COG0227 Belongs to the bacterial ribosomal protein bL28 family COG0778 Nitroreductase COG0079 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily COG0131 Imidazoleglycerol-phosphate dehydratase COG0118 IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR COG0524 Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway COG0516 GMP reductase activity COG0517 IMP dehydrogenase activity COG1495 Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein COG0008 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) COG0475 glutathione-regulated potassium exporter activity COG0569 domain protein COG2890 protein-(glutamine-N5) methyltransferase activity COG0706 membrane insertase activity COG0759 Could be involved in insertion of integral membrane proteins into the membrane COG0594 ribonuclease P activity COG0230 Belongs to the bacterial ribosomal protein bL34 family COG1022 Amp-dependent synthetase and ligase COG1121 (ABC) transporter COG1108 ABC-type Mn2 Zn2 transport systems permease components COG1959 2 iron, 2 sulfur cluster binding COG1104 cysteine desulfurase activity COG0128 3-phosphoshikimate 1-carboxyvinyltransferase activity COG0283 belongs to the cytidylate kinase family. Type 1 subfamily COG0436 Aminotransferase COG1028 Short-chain dehydrogenase reductase Sdr COG0492 ferredoxin-NADP+ reductase activity COG0604 alcohol dehydrogenase COG1028 Short-chain dehydrogenase reductase Sdr COG3321 synthase COG0747 negative chemotaxis COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components COG0517 IMP dehydrogenase activity COG0123 including yeast histone deacetylase and acetoin utilization protein COG2104 thiamine diphosphate biosynthetic process COG0037 tRNA processing COG1154 Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) COG0380 Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor COG0366 Alpha amylase catalytic COG2226 methyltransferase COG2226 methyltransferase COG0815 Transfers the fatty acyl group on membrane lipoproteins COG1600 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) COG3744 PilT protein domain protein COG1597 lipid kinase activity COG0460 homoserine dehydrogenase COG0498 Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine COG0635 Involved in the biosynthesis of porphyrin-containing compound COG3742 Toxic component of a toxin-antitoxin (TA) module. An RNase COG0247 lactate metabolic process COG0277 FAD linked oxidase domain protein COG2225 Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA COG1414 Transcriptional regulator COG0789 Transcriptional regulator COG0073 Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation COG1541 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) COG1541 Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) COG0123 including yeast histone deacetylase and acetoin utilization protein COG2151 metal-sulfur cluster biosynthetic enzyme COG2151 metal-sulfur cluster biosynthetic enzyme COG0281 malic enzyme COG0404 The glycine cleavage system catalyzes the degradation of glycine COG0509 glycine decarboxylation via glycine cleavage system COG0403 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG1003 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor COG0196 riboflavin kinase activity COG0568 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released COG2813 Specifically methylates the guanine in position COG0527 aspartate kinase activity COG0219 Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide COG4956 integral membrane protein (PIN domain superfamily) COG1066 DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function COG0542 response to heat COG0423 glycine-tRNA ligase activity COG0136 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate COG0008 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) COG0064 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) COG0290 IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins COG0292 Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit COG0344 acyl-phosphate glycerol-3-phosphate acyltransferase activity COG0004 ammonium transporteR COG0775 Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively COG0605 Destroys radicals which are normally produced within the cells and which are toxic to biological systems COG0114 fumarate hydratase activity COG0183 Belongs to the thiolase family COG0005 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate COG0325 Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis COG0347 Belongs to the P(II) protein family COG2262 GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis COG1254 Belongs to the acylphosphatase family COG1063 alcohol dehydrogenase COG2133 pyrroloquinoline quinone binding COG0324 Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) COG0154 amidase activity COG1420 regulation of RNA biosynthetic process COG0572 uridine kinase COG3842 ATPase activity COG4475 Protein of unknown function (DUF436) COG0314 molybdopterin synthase activity COG0153 Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) COG0803 Belongs to the bacterial solute-binding protein 9 family COG1232 Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX COG0276 Catalyzes the ferrous insertion into protoporphyrin IX COG0407 Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III COG0760 Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation COG0318 PFAM AMP-dependent synthetase and ligase COG0318 PFAM AMP-dependent synthetase and ligase COG0853 Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine COG0502 Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism COG1293 RNA-binding protein homologous to eukaryotic snRNP COG2519 Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA COG3870 Protein conserved in bacteria COG0458 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity COG0787 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids COG0544 peptidyl-prolyl cis-trans isomerase activity COG0740 serine-type endopeptidase activity COG1219 ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP COG1488 Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP COG0646 methionine synthase COG1410 methionine synthase COG1198 Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA COG1692 metallophosphoesterase COG2352 Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle COG1970 mechanosensitive ion channel activity COG1826 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes COG1220 this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis COG5405 Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery COG0277 FAD linked oxidase domain protein COG2148 undecaprenyl-phosphate glucose phosphotransferase activity COG1109 Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate COG0489 protein tyrosine kinase activity COG2264 protein methyltransferase activity COG1385 rRNA (uridine-N3-)-methyltransferase activity COG0574 Belongs to the PEP-utilizing enzyme family COG1080 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) COG2141 COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases COG2046 Belongs to the sulfate adenylyltransferase family COG0730 response to heat COG0175 sulfate reduction COG0007 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme COG1648 precorrin-2 dehydrogenase activity COG1842 Phage shock protein A COG1587 Uroporphyrinogen-III synthase COG0155 Belongs to the nitrite and sulfite reductase 4Fe-4S domain family COG0352 thiamine-phosphate diphosphorylase activity COG2104 thiamine diphosphate biosynthetic process COG2022 thiamine diphosphate biosynthetic process COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity COG2022 thiamine diphosphate biosynthetic process COG0422 Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction COG0477 Major facilitator Superfamily COG0351 phosphomethylpyrimidine kinase COG1175 transmembrane transport COG1175 transmembrane transport COG1940 carbohydrate kinase activity COG0183 Belongs to the thiolase family COG1028 Short-chain dehydrogenase reductase Sdr COG0341 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA COG0342 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA COG0532 One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex COG1126 abc transporter atp-binding protein COG0195 Participates in both transcription termination and antitermination COG0779 Required for maturation of 30S ribosomal subunits COG0739 heme binding COG0214 Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively COG0640 Transcriptional regulator COG2217 Heavy metal translocating P-type atpase COG0311 Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS COG0017 Asparaginyl-tRNA synthetase COG0561 phosphatase activity COG0384 phenazine biosynthesis protein PhzF COG2720 vancomycin resistance protein COG0124 histidyl-tRNA synthetase COG3842 ATPase activity COG1573 uracil-dna glycosylase COG0141 Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine COG0518 GMP synthase (glutamine-hydrolyzing) activity COG0519 Catalyzes the synthesis of GMP from XMP COG1316 TRANSCRIPTIONal COG1048 Catalyzes the isomerization of citrate to isocitrate via cis-aconitate COG0550 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone COG0295 cytidine deaminase activity COG0329 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) COG1760 l-serine dehydratase COG0209 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides COG1372 Participates in initiation and elongation during chromosome replication COG0481 GTPase activity COG0463 Glycosyl transferase, family 2 COG0609 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily COG0135 phosphoribosylanthranilate isomerase activity COG1028 Short-chain dehydrogenase reductase Sdr COG1028 Short-chain dehydrogenase reductase Sdr COG0405 Gamma-glutamyltransferase COG1073 alpha beta COG2021 Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine COG2873 o-acetylhomoserine COG1063 alcohol dehydrogenase COG3191 aminopeptidase activity COG4663 Part of the tripartite ATP-independent periplasmic (TRAP) transport system COG1593 TRAP-type C4-dicarboxylate transport system, large permease component COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain COG0466 ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner COG0167 dihydroorotate dehydrogenase activity COG1343 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette COG0044 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides COG0540 Belongs to the ATCase OTCase family COG2065 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant COG0730 response to heat COG1052 Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family COG0456 acetyltransferase COG1386 Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves COG0009 L-threonylcarbamoyladenylate synthase COG1459 type II secretion system COG0287 Prephenate dehydrogenase COG2876 3-deoxy-7-phosphoheptulonate synthase activity COG2514 catechol 2,3-dioxygenase activity COG2353 YceI-like domain COG1427 Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) COG1060 Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate COG1609 Transcriptional regulator COG0344 acyl-phosphate glycerol-3-phosphate acyltransferase activity COG0179 Fumarylacetoacetate (FAA) hydrolase COG4712 double-strand break repair protein COG0299 Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate COG0151 Belongs to the GarS family COG2176 DNA-directed DNA polymerase activity COG5002 protein histidine kinase activity COG4147 Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family COG0217 transcriptional regulatory protein COG1226 (belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family) COG4651 solute:proton antiporter activity COG1651 Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process COG0421 Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine COG1586 Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine COG1674 ftsk spoiiie COG0517 IMP dehydrogenase activity COG0030 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity COG0617 tRNA 3'-terminal CCA addition COG0618 3'(2'),5'-bisphosphate nucleotidase activity COG3620 sequence-specific DNA binding COG1994 Peptidase M50 COG0648 Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin COG0607 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS COG0838 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0607 Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS COG2719 SpoVR family COG2718 Belongs to the UPF0229 family COG2766 serine protein kinase COG2137 regulation of response to DNA damage stimulus COG0377 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG2359 stage V sporulation protein S COG0144 Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA COG0345 Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline COG0463 Glycosyl transferase, family 2 COG0750 zinc metalloprotease COG0743 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity COG4589 Belongs to the CDS family COG0233 cytoplasmic translational termination COG0852 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0528 UMP kinase activity COG0264 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome COG0052 Belongs to the universal ribosomal protein uS2 family COG0160 Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family COG0494 nUDIX hydrolase COG0649 NAD binding COG0402 S-adenosylhomocysteine deaminase activity COG4948 Mandelate Racemase Muconate Lactonizing COG0172 Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) COG0721 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) COG1811 Na channel or pump COG1905 PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit COG0665 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity COG4121 Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 COG1215 transferase activity, transferring glycosyl groups COG1215 transferase activity, transferring glycosyl groups COG0438 transferase activity, transferring glycosyl groups COG1894 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain COG2039 Removes 5-oxoproline from various penultimate amino acid residues except L-proline COG1024 Enoyl-CoA hydratase COG1250 3-hydroxyacyl-CoA dehydrogenase COG0183 Belongs to the thiolase family COG1960 acyl-CoA dehydrogenase activity COG0215 cysteine-tRNA ligase activity COG1281 Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress COG2738 Putative neutral zinc metallopeptidase COG1034 ATP synthesis coupled electron transport COG1196 nuclear chromosome segregation COG0691 Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene COG0388 Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source COG3153 acetyltransferase COG1268 BioY protein COG0126 phosphoglycerate kinase activity COG0858 One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA COG1005 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone COG0824 Thioesterase COG0557 exoribonuclease II activity COG1143 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG1355 regulation of microtubule-based process COG0617 tRNA 3'-terminal CCA addition COG1353 crispr-associated protein COG0237 dephospho-CoA kinase activity COG0839 Belongs to the complex I subunit 6 family COG0742 ribosomal rna small subunit methyltransferase COG0669 Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate COG0138 bifunctional purine biosynthesis protein purh COG0486 Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 COG0001 glutamate-1-semialdehyde 2,1-aminomutase activity COG0713 ATP synthesis coupled electron transport COG1009 NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit COG0149 triose-phosphate isomerase activity COG3239 Fatty acid desaturase COG1490 D-aminoacyl-tRNA deacylase activity COG1307 EDD domain protein, DegV family COG1307 EDD domain protein, DegV family COG0111 D-isomer specific 2-hydroxyacid dehydrogenase COG1510 regulation of RNA biosynthetic process COG3769 mannosylglycerate metabolic process COG1008 NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient COG0329 Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) COG1012 belongs to the aldehyde dehydrogenase family COG2368 4-hydroxyphenylacetate COG1853 conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family COG2050 protein possibly involved in aromatic compounds catabolism COG0588 phosphoglycerate mutase activity COG1028 Short-chain dehydrogenase reductase Sdr COG2211 Major facilitator Superfamily COG2211 Major facilitator Superfamily COG1797 cobyrinic acid a,c-diamide synthase activity COG2109 Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids COG0368 Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate COG0588 phosphoglycerate mutase activity COG3376 Belongs to the NiCoT transporter (TC 2.A.52) family COG1903 Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A COG0007 Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme COG1648 precorrin-2 dehydrogenase activity COG0778 Nitroreductase COG0079 Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily COG1492 cobalamin metabolic process COG1785 Belongs to the alkaline phosphatase family COG1414 Transcriptional regulator COG1638 TRAP-type C4-dicarboxylate transport system periplasmic component COG1593 TRAP-type C4-dicarboxylate transport system, large permease component COG1028 Short-chain dehydrogenase reductase Sdr COG1028 Short-chain dehydrogenase reductase Sdr COG2723 6-phospho-beta-galactosidase activity COG2220 Zn-dependent hydrolases of the beta-lactamase fold COG1233 COG1233 Phytoene dehydrogenase and related COG0702 epimerase COG1562 ergosterol biosynthetic process COG2124 cytochrome p450 COG1304 FMN binding COG1085 galactose-1-phosphate uridylyltransferase COG3345 alpha-galactosidase COG4966 pilus assembly protein PilW COG1475 DNA binding COG1475 DNA binding COG1192 Involved in chromosome partitioning COG0243 molybdopterin cofactor binding COG2814 Major facilitator Superfamily COG0584 glycerophosphoryl diester phosphodiesterase COG0578 Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family COG1337 RAMP superfamily COG1110 DNA topoisomerase II activity COG4565 transcriptional regulatory protein COG3842 ATPase activity COG0863 Belongs to the N(4) N(6)-methyltransferase family COG1857 crispr-associated protein COG0847 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease COG1526 Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH COG1607 acyl-coa hydrolase COG0209 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides COG0614 abc-type fe3 -hydroxamate transport system, periplasmic component COG4559 Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system COG0609 Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily COG4558 Periplasmic binding protein COG2329 Antibiotic biosynthesis monooxygenase COG1942 4-Oxalocrotonate Tautomerase COG2084 Dehydrogenase