locus-tag	class	description
TthHC11_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthHC11_00020	COG0592	DNA-directed DNA polymerase activity
TthHC11_00030	COG0148	phosphopyruvate hydratase activity
TthHC11_00040	COG0469	pyruvate kinase activity
TthHC11_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHC11_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthHC11_00090	COG1842	Phage shock protein A
TthHC11_00120	COG0406	alpha-ribazole phosphatase activity
TthHC11_00130	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthHC11_00140	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHC11_00160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthHC11_00170	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthHC11_00190	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthHC11_00200	COG1278	Cold shock
TthHC11_00210	COG1653	transport
TthHC11_00240	COG0033	Phosphoglucomutase
TthHC11_00260	COG0477	Major facilitator Superfamily
TthHC11_00280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthHC11_00280	COG0517	IMP dehydrogenase activity
TthHC11_00290	COG1950	PFAM Membrane protein of
TthHC11_00300	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthHC11_00320	COG0181	hydroxymethylbilane synthase activity
TthHC11_00340	COG0285	dihydrofolate synthase activity
TthHC11_00350	COG0436	Aminotransferase
TthHC11_00360	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthHC11_00410	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthHC11_00420	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthHC11_00430	COG1993	acr, cog1993
TthHC11_00440	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthHC11_00470	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHC11_00490	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthHC11_00500	COG1335	isochorismatase
TthHC11_00510	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthHC11_00540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthHC11_00550	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthHC11_00570	COG0242	peptide deformylase activity
TthHC11_00580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TthHC11_00590	COG1660	Displays ATPase and GTPase activities
TthHC11_00600	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthHC11_00660	COG1845	cytochrome c oxidase, subunit III
TthHC11_00660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHC11_00680	COG1612	heme a metabolic process
TthHC11_00680	COG0109	protoheme IX farnesyltransferase activity
TthHC11_00710	COG0343	queuine tRNA-ribosyltransferase activity
TthHC11_00720	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthHC11_00730	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthHC11_00780	COG1940	carbohydrate kinase activity
TthHC11_00800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHC11_00810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHC11_00820	COG0589	response to stress
TthHC11_00830	COG1611	Belongs to the LOG family
TthHC11_00850	COG1011	Hydrolase
TthHC11_00860	COG0632	four-way junction helicase activity
TthHC11_00870	COG1024	Enoyl-CoA hydratase
TthHC11_00890	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHC11_00940	COG0137	argininosuccinate synthase activity
TthHC11_00950	COG0165	Argininosuccinate lyase
TthHC11_00980	COG0505	Belongs to the CarA family
TthHC11_01000	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthHC11_01010	COG0166	Belongs to the GPI family
TthHC11_01040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHC11_01050	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthHC11_01060	COG0459	protein refolding
TthHC11_01070	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthHC11_01080	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthHC11_01100	COG0778	Nitroreductase
TthHC11_01110	COG1388	LysM domain
TthHC11_01110	COG0791	NLP P60 protein
TthHC11_01130	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthHC11_01150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthHC11_01160	COG0581	inorganic phosphate transmembrane transporter activity
TthHC11_01170	COG0573	inorganic phosphate transmembrane transporter activity
TthHC11_01180	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthHC11_01190	COG0482	sulfurtransferase activity
TthHC11_01210	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthHC11_01220	COG0735	belongs to the Fur family
TthHC11_01250	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthHC11_01260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHC11_01270	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthHC11_01280	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthHC11_01290	COG0250	Participates in transcription elongation, termination and antitermination
TthHC11_01300	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TthHC11_01310	COG0081	regulation of translation
TthHC11_01340	COG0360	Binds together with S18 to 16S ribosomal RNA
TthHC11_01350	COG0629	single-stranded DNA binding
TthHC11_01360	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthHC11_01370	COG0359	binds to the 23S rRNA
TthHC11_01390	COG0300	oxidoreductase activity
TthHC11_01400	COG0321	lipoyl(octanoyl) transferase activity
TthHC11_01410	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthHC11_01490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthHC11_01520	COG1598	PFAM Uncharacterised protein family UPF0150
TthHC11_01530	COG0022	dehydrogenase e1 component
TthHC11_01540	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthHC11_01550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthHC11_01600	COG2226	methyltransferase
TthHC11_01610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthHC11_01640	COG1187	pseudouridine synthase activity
TthHC11_01660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthHC11_01670	COG0686	Belongs to the AlaDH PNT family
TthHC11_01690	COG1461	Dihydroxyacetone kinase
TthHC11_01710	COG3584	3D domain protein
TthHC11_01710	COG3583	domain protein
TthHC11_01720	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthHC11_01730	COG0222	ribosome binding
TthHC11_01740	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthHC11_01750	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TthHC11_01760	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthHC11_01770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthHC11_01790	COG0697	spore germination
TthHC11_01810	COG3177	Filamentation induced by cAMP protein fic
TthHC11_01830	COG0243	molybdopterin cofactor binding
TthHC11_01840	COG2272	Belongs to the type-B carboxylesterase lipase family
TthHC11_01850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthHC11_01870	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHC11_01900	COG0477	Major facilitator Superfamily
TthHC11_01930	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthHC11_01950	COG0105	UTP biosynthetic process
TthHC11_01960	COG0631	protein serine/threonine phosphatase activity
TthHC11_01970	COG0583	DNA-binding transcription factor activity
TthHC11_01990	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthHC11_02060	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthHC11_02080	COG1278	Cold shock
TthHC11_02090	COG0484	heat shock protein binding
TthHC11_02100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthHC11_02110	COG1968	undecaprenyl-diphosphatase activity
TthHC11_02120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthHC11_02130	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthHC11_02160	COG1309	transcriptional regulator
TthHC11_02170	COG4242	Belongs to the peptidase S51 family
TthHC11_02200	COG0802	atpase or kinase
TthHC11_02210	COG0539	negative regulation of cytoplasmic translation
TthHC11_02220	COG0495	leucyl-tRNA aminoacylation
TthHC11_02270	COG1902	pentaerythritol trinitrate reductase activity
TthHC11_02320	COG2414	aldehyde ferredoxin oxidoreductase
TthHC11_02360	COG2165	general secretion pathway protein
TthHC11_02430	COG1459	type II secretion system
TthHC11_02450	COG1187	pseudouridine synthase activity
TthHC11_02470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHC11_02480	COG0745	RESPONSE REGULATOR receiver
TthHC11_02490	COG4191	Histidine kinase
TthHC11_02500	COG0704	Plays a role in the regulation of phosphate uptake
TthHC11_02510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthHC11_02530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthHC11_02550	COG0515	serine threonine protein kinase
TthHC11_02550	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthHC11_02590	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthHC11_02600	COG4221	oxidoreductase activity
TthHC11_02630	COG0717	Belongs to the dCTP deaminase family
TthHC11_02640	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthHC11_02650	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthHC11_02660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthHC11_02680	COG0583	DNA-binding transcription factor activity
TthHC11_02690	COG3546	catalase activity
TthHC11_02720	COG0758	DNA mediated transformation
TthHC11_02720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHC11_02730	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthHC11_02750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthHC11_02770	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthHC11_02780	COG0442	prolyl-tRNA aminoacylation
TthHC11_02790	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthHC11_02830	COG0303	'Molybdopterin
TthHC11_02840	COG0513	Belongs to the DEAD box helicase family
TthHC11_02890	COG4983	Phage plasmid primase, P4 family domain protein
TthHC11_02980	COG0582	viral genome integration into host DNA
TthHC11_02990	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
TthHC11_03010	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthHC11_03040	COG2070	2-Nitropropane dioxygenase
TthHC11_03070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthHC11_03080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHC11_03090	COG0018	arginyl-trna synthetase
TthHC11_03100	COG1007	ATP synthesis coupled electron transport
TthHC11_03110	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_03120	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthHC11_03130	COG0713	ATP synthesis coupled electron transport
TthHC11_03140	COG0839	Belongs to the complex I subunit 6 family
TthHC11_03150	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_03160	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthHC11_03170	COG1034	ATP synthesis coupled electron transport
TthHC11_03180	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthHC11_03190	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthHC11_03200	COG0649	NAD binding
TthHC11_03210	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_03220	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_03230	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthHC11_03240	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthHC11_03260	COG4712	double-strand break repair protein
TthHC11_03280	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthHC11_03310	COG0135	phosphoribosylanthranilate isomerase activity
TthHC11_03320	COG1372	Participates in initiation and elongation during chromosome replication
TthHC11_03320	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHC11_03330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthHC11_03350	COG2720	vancomycin resistance protein
TthHC11_03420	COG0277	FAD linked oxidase domain protein
TthHC11_03440	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthHC11_03460	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthHC11_03490	COG0314	molybdopterin synthase activity
TthHC11_03500	COG1420	regulation of RNA biosynthetic process
TthHC11_03510	COG0347	Belongs to the P(II) protein family
TthHC11_03520	COG0004	ammonium transporteR
TthHC11_03540	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthHC11_03560	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHC11_03590	COG1597	lipid kinase activity
TthHC11_03600	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TthHC11_03640	COG0569	domain protein
TthHC11_03640	COG0475	glutathione-regulated potassium exporter activity
TthHC11_03660	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthHC11_03680	COG0277	FAD linked oxidase domain protein
TthHC11_03770	COG2002	toxin-antitoxin pair type II binding
TthHC11_03840	COG0667	Aldo Keto reductase
TthHC11_03910	COG1067	ATP-dependent peptidase activity
TthHC11_03920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthHC11_03950	COG2105	PFAM AIG2 family protein
TthHC11_03960	COG0297	glycogen (starch) synthase activity
TthHC11_03980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthHC11_03990	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthHC11_04020	COG0142	geranyltranstransferase activity
TthHC11_04040	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthHC11_04050	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_04060	COG0492	ferredoxin-NADP+ reductase activity
TthHC11_04080	COG0792	nuclease activity
TthHC11_04090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthHC11_04120	COG1175	transmembrane transport
TthHC11_04130	COG0395	ABC-type sugar transport system, permease component
TthHC11_04210	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthHC11_04220	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthHC11_04230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthHC11_04240	COG0805	protein transport
TthHC11_04250	COG1605	Chorismate mutase
TthHC11_04250	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHC11_04360	COG1063	alcohol dehydrogenase
TthHC11_04420	COG2255	four-way junction helicase activity
TthHC11_04430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthHC11_04440	COG0564	pseudouridine synthase activity
TthHC11_04480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthHC11_04490	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthHC11_04500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthHC11_04510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthHC11_04530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthHC11_04540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthHC11_04550	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthHC11_04620	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_04630	COG0778	Nitroreductase
TthHC11_04670	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHC11_04680	COG0131	Imidazoleglycerol-phosphate dehydratase
TthHC11_04690	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthHC11_04700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthHC11_04710	COG0517	IMP dehydrogenase activity
TthHC11_04710	COG0516	GMP reductase activity
TthHC11_04740	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthHC11_04770	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHC11_04810	COG0706	membrane insertase activity
TthHC11_04820	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthHC11_04830	COG0594	ribonuclease P activity
TthHC11_04850	COG1022	Amp-dependent synthetase and ligase
TthHC11_04860	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHC11_04900	COG1121	(ABC) transporter
TthHC11_04910	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthHC11_04920	COG1959	2 iron, 2 sulfur cluster binding
TthHC11_04930	COG1104	cysteine desulfurase activity
TthHC11_04940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthHC11_04950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthHC11_04980	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_05020	COG0492	ferredoxin-NADP+ reductase activity
TthHC11_05040	COG0747	negative chemotaxis
TthHC11_05050	COG0601	transmembrane transport
TthHC11_05060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHC11_05090	COG0517	IMP dehydrogenase activity
TthHC11_05100	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthHC11_05110	COG2104	thiamine diphosphate biosynthetic process
TthHC11_05120	COG0037	tRNA processing
TthHC11_05150	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TthHC11_05170	COG0366	Alpha amylase catalytic
TthHC11_05180	COG2226	methyltransferase
TthHC11_05190	COG2226	methyltransferase
TthHC11_05200	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthHC11_05220	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthHC11_05230	COG3744	PilT protein domain protein
TthHC11_05270	COG0460	homoserine dehydrogenase
TthHC11_05290	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthHC11_05360	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthHC11_05400	COG0247	lactate metabolic process
TthHC11_05410	COG0277	FAD linked oxidase domain protein
TthHC11_05420	COG0277	FAD linked oxidase domain protein
TthHC11_05440	COG1414	Transcriptional regulator
TthHC11_05450	COG0789	Transcriptional regulator
TthHC11_05460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHC11_05470	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHC11_05480	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHC11_05550	COG0861	Integral membrane protein TerC family
TthHC11_05560	COG2151	metal-sulfur cluster biosynthetic enzyme
TthHC11_05570	COG0281	malic enzyme
TthHC11_05600	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthHC11_05610	COG0509	glycine decarboxylation via glycine cleavage system
TthHC11_05620	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHC11_05630	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthHC11_05640	COG0196	riboflavin kinase activity
TthHC11_05690	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthHC11_05700	COG2813	Specifically methylates the guanine in position
TthHC11_05720	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TthHC11_05730	COG0039	L-malate dehydrogenase activity
TthHC11_05770	COG4956	integral membrane protein (PIN domain superfamily)
TthHC11_05780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthHC11_05790	COG0542	response to heat
TthHC11_05800	COG0423	glycine-tRNA ligase activity
TthHC11_05820	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthHC11_05860	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthHC11_05860	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHC11_05880	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthHC11_05890	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TthHC11_05900	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthHC11_05920	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHC11_05930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHC11_05940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthHC11_05950	COG0114	fumarate hydratase activity
TthHC11_05960	COG0183	Belongs to the thiolase family
TthHC11_05990	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthHC11_06000	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthHC11_06030	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthHC11_06040	COG1254	Belongs to the acylphosphatase family
TthHC11_06070	COG1063	alcohol dehydrogenase
TthHC11_06080	COG2133	pyrroloquinoline quinone binding
TthHC11_06100	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthHC11_06110	COG0154	amidase activity
TthHC11_06160	COG0572	uridine kinase
TthHC11_06170	COG3842	ATPase activity
TthHC11_06200	COG4475	Protein of unknown function (DUF436)
TthHC11_06270	COG0683	leucine binding
TthHC11_06320	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHC11_06330	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthHC11_06340	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthHC11_06380	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthHC11_06390	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthHC11_06400	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthHC11_06420	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_06430	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_06450	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthHC11_06460	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
TthHC11_06480	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthHC11_06500	COG3870	Protein conserved in bacteria
TthHC11_06510	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthHC11_06530	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthHC11_06540	COG0740	serine-type endopeptidase activity
TthHC11_06550	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthHC11_06560	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthHC11_06570	COG1410	methionine synthase
TthHC11_06570	COG0646	methionine synthase
TthHC11_06590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHC11_06610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthHC11_06640	COG1692	metallophosphoesterase
TthHC11_06650	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthHC11_06660	COG1970	mechanosensitive ion channel activity
TthHC11_06830	COG2189	Belongs to the N(4) N(6)-methyltransferase family
TthHC11_06850	COG0582	viral genome integration into host DNA
TthHC11_06880	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthHC11_06890	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthHC11_06980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TthHC11_07010	COG0438	transferase activity, transferring glycosyl groups
TthHC11_07040	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHC11_07090	COG0489	protein tyrosine kinase activity
TthHC11_07110	COG2264	protein methyltransferase activity
TthHC11_07120	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthHC11_07180	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHC11_07180	COG0574	Belongs to the PEP-utilizing enzyme family
TthHC11_07200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthHC11_07210	COG2046	Belongs to the sulfate adenylyltransferase family
TthHC11_07220	COG1648	precorrin-2 dehydrogenase activity
TthHC11_07220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHC11_07230	COG0730	response to heat
TthHC11_07240	COG0175	sulfate reduction
TthHC11_07250	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHC11_07250	COG1648	precorrin-2 dehydrogenase activity
TthHC11_07260	COG1587	Uroporphyrinogen-III synthase
TthHC11_07270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthHC11_07290	COG0352	thiamine-phosphate diphosphorylase activity
TthHC11_07300	COG2104	thiamine diphosphate biosynthetic process
TthHC11_07310	COG2022	thiamine diphosphate biosynthetic process
TthHC11_07320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_07320	COG2022	thiamine diphosphate biosynthetic process
TthHC11_07330	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthHC11_07340	COG0477	Major facilitator Superfamily
TthHC11_07350	COG0351	phosphomethylpyrimidine kinase
TthHC11_07430	COG1940	carbohydrate kinase activity
TthHC11_07440	COG0183	Belongs to the thiolase family
TthHC11_07470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHC11_07470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthHC11_07490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthHC11_07510	COG0195	Participates in both transcription termination and antitermination
TthHC11_07520	COG0779	Required for maturation of 30S ribosomal subunits
TthHC11_07530	COG0739	heme binding
TthHC11_07540	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthHC11_07550	COG0640	Transcriptional regulator
TthHC11_07560	COG2217	Heavy metal translocating P-type atpase
TthHC11_07570	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthHC11_07580	COG0017	Asparaginyl-tRNA synthetase
TthHC11_07590	COG0561	phosphatase activity
TthHC11_07600	COG0384	phenazine biosynthesis protein PhzF
TthHC11_07610	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TthHC11_07620	COG0124	histidyl-tRNA synthetase
TthHC11_07640	COG3842	ATPase activity
TthHC11_07670	COG1573	uracil-dna glycosylase
TthHC11_07710	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthHC11_07720	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHC11_07720	COG0519	Catalyzes the synthesis of GMP from XMP
TthHC11_07740	COG1316	TRANSCRIPTIONal
TthHC11_07750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthHC11_07840	COG0295	cytidine deaminase activity
TthHC11_07860	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHC11_07880	COG1760	l-serine dehydratase
TthHC11_07900	COG0481	GTPase activity
TthHC11_07920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHC11_07950	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_08040	COG3706	GGDEF domain
TthHC11_08050	COG0405	Gamma-glutamyltransferase
TthHC11_08060	COG1073	alpha beta
TthHC11_08090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthHC11_08100	COG2873	o-acetylhomoserine
TthHC11_08130	COG1063	alcohol dehydrogenase
TthHC11_08160	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthHC11_08180	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHC11_08190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthHC11_08200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHC11_08210	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthHC11_08220	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TthHC11_08230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthHC11_08250	COG0167	dihydroorotate dehydrogenase activity
TthHC11_08270	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TthHC11_08280	COG0540	Belongs to the ATCase OTCase family
TthHC11_08290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TthHC11_08310	COG0730	response to heat
TthHC11_08320	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthHC11_08340	COG0312	modulator of DNA gyrase
TthHC11_08360	COG1960	acyl-CoA dehydrogenase activity
TthHC11_08370	COG0456	acetyltransferase
TthHC11_08390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthHC11_08400	COG0009	L-threonylcarbamoyladenylate synthase
TthHC11_08440	COG0277	FAD linked oxidase domain protein
TthHC11_08460	COG0287	Prephenate dehydrogenase
TthHC11_08470	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthHC11_08480	COG2514	catechol 2,3-dioxygenase activity
TthHC11_08490	COG2353	YceI-like domain
TthHC11_08500	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHC11_08510	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHC11_08550	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHC11_08560	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthHC11_08580	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthHC11_08590	COG0151	Belongs to the GarS family
TthHC11_08600	COG2176	DNA-directed DNA polymerase activity
TthHC11_08600	COG5002	protein histidine kinase activity
TthHC11_08660	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthHC11_08680	COG0217	transcriptional regulatory protein
TthHC11_08690	COG4651	solute:proton antiporter activity
TthHC11_08690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthHC11_08700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthHC11_08710	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthHC11_08720	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHC11_08730	COG1674	ftsk spoiiie
TthHC11_08760	COG0517	IMP dehydrogenase activity
TthHC11_08800	COG1994	Peptidase M50
TthHC11_08810	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthHC11_08830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHC11_08860	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthHC11_08880	COG2719	SpoVR family
TthHC11_08890	COG2718	Belongs to the UPF0229 family
TthHC11_08900	COG2766	serine protein kinase
TthHC11_08950	COG2137	regulation of response to DNA damage stimulus
TthHC11_08970	COG2359	stage V sporulation protein S
TthHC11_08980	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHC11_08990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthHC11_09020	COG0750	zinc metalloprotease
TthHC11_09030	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthHC11_09040	COG4589	Belongs to the CDS family
TthHC11_09050	COG0233	cytoplasmic translational termination
TthHC11_09060	COG0528	UMP kinase activity
TthHC11_09070	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthHC11_09080	COG0052	Belongs to the universal ribosomal protein uS2 family
TthHC11_09280	COG0494	nUDIX hydrolase
TthHC11_09340	COG0402	S-adenosylhomocysteine deaminase activity
TthHC11_09360	COG4948	Mandelate Racemase Muconate Lactonizing
TthHC11_09370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthHC11_09380	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthHC11_09390	COG1811	Na channel or pump
TthHC11_09400	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_09400	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthHC11_09430	COG1215	transferase activity, transferring glycosyl groups
TthHC11_09450	COG1215	transferase activity, transferring glycosyl groups
TthHC11_09470	COG0438	transferase activity, transferring glycosyl groups
TthHC11_09480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthHC11_09510	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_09520	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHC11_09530	COG1063	alcohol dehydrogenase
TthHC11_09560	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_09590	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
TthHC11_09610	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHC11_09610	COG1024	Enoyl-CoA hydratase
TthHC11_09620	COG0183	Belongs to the thiolase family
TthHC11_09630	COG1960	acyl-CoA dehydrogenase activity
TthHC11_09640	COG0215	cysteine-tRNA ligase activity
TthHC11_09650	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthHC11_09670	COG2738	Putative neutral zinc metallopeptidase
TthHC11_09700	COG1196	nuclear chromosome segregation
TthHC11_09730	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthHC11_09740	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHC11_09740	COG3153	acetyltransferase
TthHC11_09750	COG1268	BioY protein
TthHC11_09770	COG0126	phosphoglycerate kinase activity
TthHC11_09780	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthHC11_09790	COG0824	Thioesterase
TthHC11_09810	COG0557	exoribonuclease II activity
TthHC11_09830	COG1355	regulation of microtubule-based process
TthHC11_09840	COG0617	tRNA 3'-terminal CCA addition
TthHC11_09850	COG0237	dephospho-CoA kinase activity
TthHC11_09870	COG0742	ribosomal rna small subunit methyltransferase
TthHC11_09880	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthHC11_09890	COG0138	bifunctional purine biosynthesis protein purh
TthHC11_09900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthHC11_09930	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthHC11_10080	COG0149	triose-phosphate isomerase activity
TthHC11_10090	COG3239	Fatty acid desaturase
TthHC11_10100	COG1490	D-aminoacyl-tRNA deacylase activity
TthHC11_10110	COG1307	EDD domain protein, DegV family
TthHC11_10120	COG1307	EDD domain protein, DegV family
TthHC11_10130	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthHC11_10160	COG3769	mannosylglycerate metabolic process
TthHC11_10180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthHC11_10200	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_10210	COG2368	4-hydroxyphenylacetate
TthHC11_10220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TthHC11_10250	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHC11_10260	COG0411	ABC transporter
TthHC11_10270	COG0410	ABC transporter
TthHC11_10280	COG2050	protein possibly involved in aromatic compounds catabolism
TthHC11_10290	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthHC11_10310	COG2030	dehydratase
TthHC11_10310	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_10350	COG3396	Phenylacetate-CoA oxygenase
TthHC11_10370	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthHC11_10430	COG1980	fructose-bisphosphate aldolase activity
TthHC11_10440	COG1733	regulation of RNA biosynthetic process
TthHC11_10450	COG2193	ferroxidase activity
TthHC11_10460	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthHC11_10470	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthHC11_10490	COG1331	Highly conserved protein containing a thioredoxin domain
TthHC11_10500	COG0183	Belongs to the thiolase family
TthHC11_10510	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TthHC11_10520	COG0477	Major facilitator Superfamily
TthHC11_10530	COG1846	Transcriptional regulator
TthHC11_10590	COG0745	RESPONSE REGULATOR receiver
TthHC11_10600	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_10620	COG0248	Ppx GppA phosphatase
TthHC11_10630	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthHC11_10640	COG0210	DNA helicase
TthHC11_10680	COG0745	RESPONSE REGULATOR receiver
TthHC11_10690	COG2205	protein histidine kinase activity
TthHC11_10720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TthHC11_10750	COG1136	(ABC) transporter
TthHC11_10760	COG0577	efflux transmembrane transporter activity
TthHC11_10760	COG1136	(ABC) transporter
TthHC11_10840	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHC11_10890	COG0582	viral genome integration into host DNA
TthHC11_10900	COG2897	thiosulfate sulfurtransferase activity
TthHC11_10910	COG1760	l-serine dehydratase
TthHC11_10920	COG2197	response regulator
TthHC11_10930	COG0335	large ribosomal subunit rRNA binding
TthHC11_10940	COG0336	Belongs to the RNA methyltransferase TrmD family
TthHC11_10950	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthHC11_10960	COG1837	Belongs to the UPF0109 family
TthHC11_10970	COG0228	four-way junction DNA binding
TthHC11_11000	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthHC11_11020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthHC11_11030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TthHC11_11040	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthHC11_11060	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthHC11_11070	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthHC11_11080	COG1702	phosphate starvation-inducible protein PhoH
TthHC11_11100	COG4864	UPF0365 protein
TthHC11_11120	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthHC11_11160	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHC11_11160	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthHC11_11170	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthHC11_11190	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthHC11_11200	COG1397	ADP-ribosylglycohydrolase
TthHC11_11210	COG2239	Acts as a magnesium transporter
TthHC11_11230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHC11_11230	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthHC11_11250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHC11_11250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthHC11_11260	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthHC11_11270	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthHC11_11280	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthHC11_11290	COG0006	proline dipeptidase activity
TthHC11_11310	COG0739	heme binding
TthHC11_11330	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthHC11_11340	COG0254	rRNA binding
TthHC11_11360	COG2001	Belongs to the MraZ family
TthHC11_11370	COG0275	rRNA processing
TthHC11_11390	COG0768	penicillin binding
TthHC11_11400	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthHC11_11420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHC11_11430	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthHC11_11440	COG0772	Belongs to the SEDS family
TthHC11_11450	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthHC11_11460	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthHC11_11470	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthHC11_11510	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthHC11_11530	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthHC11_11550	COG0159	tryptophan synthase activity
TthHC11_11560	COG0133	tryptophan synthase activity
TthHC11_11570	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthHC11_11580	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthHC11_11700	COG0438	transferase activity, transferring glycosyl groups
TthHC11_11710	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthHC11_11730	COG0039	L-malate dehydrogenase activity
TthHC11_11740	COG2819	hydrolase of the alpha beta superfamily
TthHC11_11770	COG2181	nitrate reductase activity
TthHC11_11770	COG0247	lactate metabolic process
TthHC11_11790	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthHC11_11800	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthHC11_11810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthHC11_11830	COG0439	Biotin carboxylase
TthHC11_11840	COG0511	ligase activity, forming carbon-carbon bonds
TthHC11_11850	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthHC11_11890	COG0010	Belongs to the arginase family
TthHC11_11920	COG1100	Small GTP-binding protein
TthHC11_11940	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthHC11_11950	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthHC11_11970	COG2814	Major facilitator Superfamily
TthHC11_11980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthHC11_11990	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHC11_12000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthHC11_12020	COG0745	RESPONSE REGULATOR receiver
TthHC11_12030	COG5002	protein histidine kinase activity
TthHC11_12040	COG1960	acyl-CoA dehydrogenase activity
TthHC11_12050	COG2086	electron transfer activity
TthHC11_12060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthHC11_12080	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHC11_12090	COG1573	uracil-dna glycosylase
TthHC11_12100	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthHC11_12100	COG1796	DNA polymerase
TthHC11_12130	COG2309	aminopeptidase activity
TthHC11_12170	COG2873	o-acetylhomoserine
TthHC11_12200	COG1126	abc transporter atp-binding protein
TthHC11_12220	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHC11_12230	COG3311	Transcriptional regulator
TthHC11_12250	COG0134	indole-3-glycerol-phosphate synthase activity
TthHC11_12260	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthHC11_12280	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthHC11_12300	COG0525	valine-tRNA ligase activity
TthHC11_12310	COG0765	amino acid transport
TthHC11_12320	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthHC11_12340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthHC11_12350	COG0569	domain protein
TthHC11_12360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHC11_12370	COG1426	Protein conserved in bacteria
TthHC11_12380	COG2313	pseudouridylate synthase activity
TthHC11_12410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHC11_12430	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthHC11_12470	COG0012	GTP binding
TthHC11_12480	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthHC11_12500	COG0424	maF-like protein
TthHC11_12530	COG0768	penicillin binding
TthHC11_12590	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthHC11_12600	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHC11_12620	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthHC11_12650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthHC11_12670	COG1131	(ABC) transporter
TthHC11_12710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthHC11_12740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthHC11_12750	COG0440	acetolactate synthase activity
TthHC11_12760	COG0028	Belongs to the TPP enzyme family
TthHC11_12770	COG0492	ferredoxin-NADP+ reductase activity
TthHC11_12830	COG2165	general secretion pathway protein
TthHC11_12900	COG0180	Tryptophanyl-tRNA synthetase
TthHC11_12930	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHC11_12940	COG0066	3-isopropylmalate dehydratase activity
TthHC11_12950	COG0473	3-isopropylmalate dehydrogenase activity
TthHC11_12980	COG0300	oxidoreductase activity
TthHC11_12990	COG0129	dihydroxy-acid dehydratase activity
TthHC11_13010	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthHC11_13020	COG1177	transmembrane transport
TthHC11_13030	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthHC11_13040	COG3842	ATPase activity
TthHC11_13050	COG0772	Belongs to the SEDS family
TthHC11_13060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthHC11_13070	COG2894	cell division
TthHC11_13080	COG1733	regulation of RNA biosynthetic process
TthHC11_13120	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_13130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_13140	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_13150	COG0653	protein targeting
TthHC11_13160	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthHC11_13200	COG0393	Putative heavy-metal-binding
TthHC11_13210	COG1205	dead DEAH box helicase
TthHC11_13210	COG1111	helicase
TthHC11_13240	COG0358	DNA primase activity
TthHC11_13260	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthHC11_13270	COG0612	Peptidase, M16
TthHC11_13280	COG0612	Peptidase, M16
TthHC11_13290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthHC11_13320	COG1394	ATPase activity, coupled to movement of substances
TthHC11_13330	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthHC11_13340	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthHC11_13350	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHC11_13360	COG1527	subunit (C
TthHC11_13370	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthHC11_13390	COG1269	ATP hydrolysis coupled proton transport
TthHC11_13440	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHC11_13460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthHC11_13490	COG0419	ATPase involved in DNA repair
TthHC11_13500	COG0420	3'-5' exonuclease activity
TthHC11_13540	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthHC11_13550	COG2884	Cell division ATP-binding protein ftsE
TthHC11_13560	COG0793	Belongs to the peptidase S41A family
TthHC11_13580	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHC11_13580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHC11_13590	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthHC11_13600	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthHC11_13640	COG1129	ABC transporter
TthHC11_13650	COG0746	molybdenum cofactor guanylyltransferase activity
TthHC11_13670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHC11_13710	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthHC11_13720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthHC11_13730	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthHC11_13750	COG1994	Peptidase M50
TthHC11_13750	COG0517	IMP dehydrogenase activity
TthHC11_13820	COG0788	formyltetrahydrofolate deformylase activity
TthHC11_13830	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthHC11_13840	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthHC11_13850	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthHC11_13870	COG2010	Cytochrome c
TthHC11_13890	COG0737	Belongs to the 5'-nucleotidase family
TthHC11_13900	COG0174	glutamine synthetase
TthHC11_13920	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHC11_13960	COG0747	negative chemotaxis
TthHC11_13970	COG0601	transmembrane transport
TthHC11_13980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHC11_14000	COG0285	dihydrofolate synthase activity
TthHC11_14010	COG1132	(ABC) transporter
TthHC11_14020	COG1132	(ABC) transporter
TthHC11_14030	COG0372	Belongs to the citrate synthase family
TthHC11_14040	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthHC11_14050	COG1482	cell wall glycoprotein biosynthetic process
TthHC11_14070	COG1515	deoxyribonuclease V activity
TthHC11_14090	COG0776	regulation of translation
TthHC11_14120	COG2197	response regulator
TthHC11_14130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthHC11_14140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthHC11_14150	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthHC11_14160	COG1324	tolerance protein
TthHC11_14190	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHC11_14230	COG2205	protein histidine kinase activity
TthHC11_14270	COG0247	lactate metabolic process
TthHC11_14280	COG1139	Iron-sulfur cluster binding protein
TthHC11_14290	COG1556	Lactate utilization protein
TthHC11_14310	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthHC11_14320	COG2815	serine threonine protein kinase
TthHC11_14320	COG0515	serine threonine protein kinase
TthHC11_14340	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthHC11_14360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthHC11_14400	COG0473	3-isopropylmalate dehydrogenase activity
TthHC11_14450	COG1450	Type ii and iii secretion system protein
TthHC11_14460	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthHC11_14470	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthHC11_14480	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthHC11_14490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthHC11_14490	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthHC11_14500	COG0736	holo-[acyl-carrier-protein] synthase activity
TthHC11_14530	COG1160	GTP binding
TthHC11_14540	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthHC11_14550	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthHC11_14550	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthHC11_14560	COG0083	homoserine kinase activity
TthHC11_14580	COG0268	Binds directly to 16S ribosomal RNA
TthHC11_14600	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthHC11_14610	COG0723	plastoquinol--plastocyanin reductase activity
TthHC11_14630	COG3088	subunit of a heme lyase
TthHC11_14630	COG4235	cytochrome complex assembly
TthHC11_14640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHC11_14650	COG1138	Cytochrome C-type biogenesis protein
TthHC11_14660	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthHC11_14670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHC11_14680	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthHC11_14690	COG4133	protoheme IX ABC transporter activity
TthHC11_14700	COG0785	Cytochrome C biogenesis protein
TthHC11_14710	COG3258	Cytochrome c
TthHC11_14730	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHC11_14760	COG3258	Cytochrome c
TthHC11_14770	COG2010	Cytochrome c
TthHC11_14780	COG0737	Belongs to the 5'-nucleotidase family
TthHC11_14790	COG2010	Cytochrome c
TthHC11_14800	COG3258	Cytochrome c
TthHC11_14840	COG2010	Cytochrome c
TthHC11_14850	COG3842	ATPase activity
TthHC11_14910	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_14920	COG3360	Dodecin
TthHC11_14950	COG1024	Enoyl-CoA hydratase
TthHC11_14960	COG0813	purine-nucleoside phosphorylase activity
TthHC11_14970	COG1136	(ABC) transporter
TthHC11_14980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthHC11_14990	COG2045	Belongs to the ComB family
TthHC11_15000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHC11_15010	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthHC11_15030	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthHC11_15050	COG0107	imidazoleglycerol-phosphate synthase activity
TthHC11_15060	COG0140	phosphoribosyl-ATP diphosphatase activity
TthHC11_15060	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthHC11_15070	COG1494	fructose-1,6-bisphosphatase
TthHC11_15080	COG0686	Belongs to the AlaDH PNT family
TthHC11_15090	COG0427	acetyl-CoA hydrolase
TthHC11_15100	COG0084	hydrolase, TatD family'
TthHC11_15110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthHC11_15130	COG0017	Asparaginyl-tRNA synthetase
TthHC11_15140	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthHC11_15170	COG2009	succinate dehydrogenase
TthHC11_15180	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthHC11_15240	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_15250	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthHC11_15260	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthHC11_15270	COG0504	CTP synthase activity
TthHC11_15290	COG0069	glutamate synthase activity
TthHC11_15290	COG0067	glutamate synthase
TthHC11_15290	COG0070	glutamate synthase
TthHC11_15310	COG0840	transmembrane signaling receptor activity
TthHC11_15320	COG0305	Participates in initiation and elongation during chromosome replication
TthHC11_15330	COG0741	lytic transglycosylase activity
TthHC11_15340	COG0475	glutathione-regulated potassium exporter activity
TthHC11_15350	COG2239	Acts as a magnesium transporter
TthHC11_15380	COG0475	glutathione-regulated potassium exporter activity
TthHC11_15390	COG0490	domain, Protein
TthHC11_15430	COG3118	belongs to the thioredoxin family
TthHC11_15490	COG0542	response to heat
TthHC11_15500	COG0789	Transcriptional regulator
TthHC11_15510	COG0484	heat shock protein binding
TthHC11_15520	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthHC11_15530	COG0443	Heat shock 70 kDa protein
TthHC11_15540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthHC11_15550	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthHC11_15560	COG0616	signal peptide processing
TthHC11_15590	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthHC11_15600	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthHC11_15610	COG0714	Associated with various cellular activities
TthHC11_15620	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthHC11_15620	COG0574	Belongs to the PEP-utilizing enzyme family
TthHC11_15630	COG1272	protein, Hemolysin III
TthHC11_15650	COG3850	Histidine kinase
TthHC11_15650	COG5002	protein histidine kinase activity
TthHC11_15680	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthHC11_15750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthHC11_15770	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthHC11_15790	COG0047	phosphoribosylformylglycinamidine synthase activity
TthHC11_15810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthHC11_15820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthHC11_15830	COG0116	Belongs to the methyltransferase superfamily
TthHC11_15860	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthHC11_15870	COG0497	DNA recombination
TthHC11_15890	COG0604	alcohol dehydrogenase
TthHC11_15930	COG0585	pseudouridine synthase activity
TthHC11_15970	COG0557	exoribonuclease II activity
TthHC11_15980	COG0538	isocitrate dehydrogenase activity
TthHC11_15990	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_16000	COG0590	tRNA wobble adenosine to inosine editing
TthHC11_16000	COG0037	tRNA processing
TthHC11_16020	COG2267	carboxylic ester hydrolase activity
TthHC11_16040	COG2050	protein possibly involved in aromatic compounds catabolism
TthHC11_16060	COG0322	excinuclease ABC activity
TthHC11_16070	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHC11_16080	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthHC11_16090	COG1854	S-ribosylhomocysteine lyase activity
TthHC11_16100	COG0519	Catalyzes the synthesis of GMP from XMP
TthHC11_16100	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthHC11_16120	COG4274	PFAM GYD family protein
TthHC11_16130	COG0346	lactoylglutathione lyase activity
TthHC11_16140	COG0328	RNA-DNA hybrid ribonuclease activity
TthHC11_16150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthHC11_16160	COG2095	MarC family integral membrane protein
TthHC11_16170	COG1438	arginine binding
TthHC11_16180	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthHC11_16190	COG1758	RNA polymerase activity
TthHC11_16200	COG0194	GDP metabolic process
TthHC11_16220	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthHC11_16230	COG2385	sporulation resulting in formation of a cellular spore
TthHC11_16240	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthHC11_16260	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthHC11_16340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHC11_16350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthHC11_16360	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_16370	COG0506	proline dehydrogenase activity
TthHC11_16400	COG0156	8-amino-7-oxononanoate synthase activity
TthHC11_16410	COG0732	type I restriction modification DNA specificity domain
TthHC11_16410	COG0827	DNA restriction-modification system
TthHC11_16440	COG0187	DNA topoisomerase II activity
TthHC11_16450	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthHC11_16460	COG0193	aminoacyl-tRNA hydrolase activity
TthHC11_16470	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthHC11_16520	COG0515	serine threonine protein kinase
TthHC11_16520	COG2815	serine threonine protein kinase
TthHC11_16530	COG0631	protein serine/threonine phosphatase activity
TthHC11_16560	COG0113	porphobilinogen synthase activity
TthHC11_16570	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthHC11_16580	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthHC11_16630	COG1506	peptidase
TthHC11_16630	COG4946	Tricorn protease homolog
TthHC11_16630	COG0823	Involved in the tonB-independent uptake of proteins
TthHC11_16640	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthHC11_16650	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthHC11_16690	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthHC11_16700	COG1011	Hydrolase
TthHC11_16750	COG0537	adenosine 5'-monophosphoramidase activity
TthHC11_16760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthHC11_16770	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthHC11_16780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthHC11_16790	COG0071	Belongs to the small heat shock protein (HSP20) family
TthHC11_16800	COG2897	thiosulfate sulfurtransferase activity
TthHC11_16810	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthHC11_16830	COG1764	response to oxidative stress
TthHC11_16860	COG1840	ABC-type Fe3 transport system, periplasmic component
TthHC11_16880	COG3842	ATPase activity
TthHC11_16890	COG0101	tRNA pseudouridine synthase activity
TthHC11_16900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthHC11_16910	COG0601	transmembrane transport
TthHC11_16920	COG0747	negative chemotaxis
TthHC11_16960	COG0006	proline dipeptidase activity
TthHC11_16970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthHC11_17000	COG1166	arginine decarboxylase activity
TthHC11_17010	COG3706	GGDEF domain
TthHC11_17030	COG3706	GGDEF domain
TthHC11_17040	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthHC11_17050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthHC11_17060	COG1611	Belongs to the LOG family
TthHC11_17070	COG1193	negative regulation of DNA recombination
TthHC11_17090	COG0366	Alpha amylase catalytic
TthHC11_17110	COG3833	ABC-type maltose transport systems, permease component
TthHC11_17120	COG1175	transmembrane transport
TthHC11_17150	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthHC11_17160	COG0142	geranyltranstransferase activity
TthHC11_17240	COG0203	ribosomal protein L17
TthHC11_17250	COG0202	RNA polymerase activity
TthHC11_17260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthHC11_17270	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthHC11_17280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthHC11_17290	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthHC11_17310	COG0563	adenylate kinase activity
TthHC11_17320	COG0201	protein transport
TthHC11_17330	COG0200	Binds to the 23S rRNA
TthHC11_17340	COG1841	ribosomal large subunit assembly
TthHC11_17350	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TthHC11_17360	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TthHC11_17370	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthHC11_17380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthHC11_17390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthHC11_17400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TthHC11_17410	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TthHC11_17430	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TthHC11_17440	COG0255	Belongs to the universal ribosomal protein uL29 family
TthHC11_17450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthHC11_17460	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthHC11_17470	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TthHC11_17480	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthHC11_17490	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthHC11_17500	COG0089	rRNA binding
TthHC11_17510	COG0088	Forms part of the polypeptide exit tunnel
TthHC11_17520	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TthHC11_17530	COG0051	transcription antitermination factor activity, RNA binding
TthHC11_17540	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthHC11_17550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthHC11_17560	COG0049	tRNA binding
TthHC11_17570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TthHC11_17590	COG0442	prolyl-tRNA aminoacylation
TthHC11_17630	COG1115	amino acid carrier protein
TthHC11_17670	COG1489	DNA binding
TthHC11_17730	COG0432	Pfam Uncharacterised protein family UPF0047
TthHC11_17750	COG0668	transmembrane transport
TthHC11_17770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthHC11_17780	COG2217	Heavy metal translocating P-type atpase
TthHC11_17820	COG0745	RESPONSE REGULATOR receiver
TthHC11_17830	COG2205	protein histidine kinase activity
TthHC11_17870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthHC11_17880	COG2226	methyltransferase
TthHC11_17920	COG2132	Multicopper oxidase
TthHC11_17940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthHC11_17950	COG0822	iron-sulfur transferase activity
TthHC11_17990	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthHC11_18010	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthHC11_18020	COG0284	orotidine-5'-phosphate decarboxylase activity
TthHC11_18040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthHC11_18060	COG0416	fatty acid biosynthetic process
TthHC11_18070	COG3118	belongs to the thioredoxin family
TthHC11_18080	COG1185	polyribonucleotide nucleotidyltransferase activity
TthHC11_18110	COG0438	transferase activity, transferring glycosyl groups
TthHC11_18150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthHC11_18180	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthHC11_18200	COG3706	GGDEF domain
TthHC11_18260	COG0437	4 iron, 4 sulfur cluster binding
TthHC11_18290	COG0825	malonyl-CoA metabolic process
TthHC11_18300	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthHC11_18370	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthHC11_18420	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthHC11_18430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthHC11_18440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthHC11_18450	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthHC11_18530	COG3328	transposase activity
TthHC11_18580	COG0315	cyclic pyranopterin monophosphate synthase activity
TthHC11_18600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthHC11_18630	COG1694	Mazg nucleotide pyrophosphohydrolase
TthHC11_18640	COG1803	Methylglyoxal synthase
TthHC11_18660	COG0301	tRNA thio-modification
TthHC11_18670	COG0154	amidase activity
TthHC11_18680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthHC11_18710	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthHC11_18720	COG1607	acyl-coa hydrolase
TthHC11_18740	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthHC11_18750	COG4149	molybdate abc transporter
TthHC11_18760	COG1840	ABC-type Fe3 transport system, periplasmic component
TthHC11_18790	COG0235	Class ii aldolase
TthHC11_18800	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthHC11_18810	COG0085	RNA polymerase activity
TthHC11_18830	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthHC11_18840	COG1077	Cell shape determining protein MreB Mrl
TthHC11_18850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthHC11_18850	COG1418	mRNA catabolic process
TthHC11_18860	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthHC11_18870	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthHC11_18880	COG1058	Belongs to the CinA family
TthHC11_18880	COG1546	Belongs to the CinA family
TthHC11_18890	COG0354	folic acid binding
TthHC11_18920	COG4948	Mandelate Racemase Muconate Lactonizing
TthHC11_18950	COG1175	transmembrane transport
TthHC11_18970	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthHC11_18990	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthHC11_19010	COG1136	(ABC) transporter
TthHC11_19010	COG0577	efflux transmembrane transporter activity
TthHC11_19020	COG4181	ATPase activity
TthHC11_19030	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthHC11_19060	COG0396	ATPase activity
TthHC11_19070	COG0719	Fe-S assembly protein
TthHC11_19080	COG0719	Fe-S assembly protein
TthHC11_19090	COG2146	nitrite reductase [NAD(P)H] activity
TthHC11_19100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TthHC11_19110	COG0512	Glutamine amidotransferase of anthranilate synthase
TthHC11_19120	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthHC11_19200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthHC11_19210	COG2226	methyltransferase
TthHC11_19260	COG1774	PSP1 C-terminal conserved region
TthHC11_19270	COG0470	DNA polymerase III
TthHC11_19340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthHC11_19350	COG0302	gtp cyclohydrolase
TthHC11_19410	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthHC11_19430	COG0395	ABC-type sugar transport system, permease component
TthHC11_19440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthHC11_19450	COG1131	(ABC) transporter
TthHC11_19490	COG0556	nucleotide-excision repair
TthHC11_19510	COG0497	DNA recombination
TthHC11_19520	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthHC11_19530	COG0445	tRNA wobble uridine modification
TthHC11_19580	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthHC11_19580	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthHC11_19590	COG1543	Belongs to the glycosyl hydrolase 57 family
TthHC11_19600	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHC11_19610	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthHC11_19640	COG0189	ligase activity
TthHC11_19670	COG0066	3-isopropylmalate dehydratase activity
TthHC11_19680	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthHC11_19690	COG1598	PFAM Uncharacterised protein family UPF0150
TthHC11_19720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthHC11_19730	COG1960	acyl-CoA dehydrogenase activity
TthHC11_19740	COG0163	prenyltransferase activity
TthHC11_19800	COG4555	ABC transporter
TthHC11_19820	COG2096	Adenosyltransferase
TthHC11_19850	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthHC11_19860	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthHC11_19890	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthHC11_19900	COG0723	plastoquinol--plastocyanin reductase activity
TthHC11_19920	COG2010	Cytochrome c
TthHC11_19960	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthHC11_19970	COG1960	acyl-CoA dehydrogenase activity
TthHC11_19990	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthHC11_20030	COG0393	Putative heavy-metal-binding
TthHC11_20050	COG3956	TIGRFAM MazG family protein
TthHC11_20070	COG0693	protein deglycase activity
TthHC11_20080	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthHC11_20100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthHC11_20110	COG1937	Protein conserved in bacteria
TthHC11_20130	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthHC11_20130	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthHC11_20140	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthHC11_20150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthHC11_20160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TthHC11_20170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthHC11_20170	COG0072	phenylalanine-tRNA ligase activity
TthHC11_20190	COG0205	6-phosphofructokinase activity
TthHC11_20200	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthHC11_20220	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthHC11_20250	COG0658	competence protein
TthHC11_20250	COG2333	competence protein COMEC
TthHC11_20260	COG1475	DNA binding
TthHC11_20270	COG1192	Involved in chromosome partitioning
TthHC11_20280	COG0357	Ribosomal RNA small subunit methyltransferase G
TthHC11_20290	COG0445	tRNA wobble uridine modification
TthHC11_20410	COG0411	ABC transporter
TthHC11_20420	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_20440	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthHC11_20470	COG1960	acyl-CoA dehydrogenase activity
TthHC11_20490	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_20500	COG2030	dehydratase
TthHC11_20500	COG1012	belongs to the aldehyde dehydrogenase family
TthHC11_20520	COG0318	PFAM AMP-dependent synthetase and ligase
TthHC11_20530	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_20570	COG0588	phosphoglycerate mutase activity
TthHC11_20820	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthHC11_20930	COG2329	Antibiotic biosynthesis monooxygenase
TthHC11_20950	COG4558	Periplasmic binding protein
TthHC11_20960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthHC11_20970	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
TthHC11_20990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
TthHC11_21020	COG3706	GGDEF domain
TthHC11_21120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthHC11_21140	COG1607	acyl-coa hydrolase
TthHC11_21200	COG1403	HNH endonuclease
TthHC11_21220	COG4974	Belongs to the 'phage' integrase family
TthHC11_21280	COG2329	Antibiotic biosynthesis monooxygenase
TthHC11_21400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
TthHC11_21410	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TthHC11_21500	COG0514	ATP-dependent DNA helicase (RecQ)
TthHC11_21540	COG1110	DNA topoisomerase II activity
TthHC11_21560	COG2414	aldehyde ferredoxin oxidoreductase
TthHC11_21720	COG2801	Transposase and inactivated derivatives
TthHC11_21740	COG0739	heme binding
TthHC11_21760	COG2211	Major facilitator Superfamily
TthHC11_21820	COG2211	Major facilitator Superfamily
TthHC11_21890	COG1797	cobyrinic acid a,c-diamide synthase activity
TthHC11_21920	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TthHC11_21950	COG0588	phosphoglycerate mutase activity
TthHC11_21960	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TthHC11_21970	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TthHC11_22060	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthHC11_22060	COG1648	precorrin-2 dehydrogenase activity
TthHC11_22070	COG0778	Nitroreductase
TthHC11_22110	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthHC11_22130	COG1492	cobalamin metabolic process
TthHC11_22140	COG1785	Belongs to the alkaline phosphatase family
TthHC11_22200	COG1414	Transcriptional regulator
TthHC11_22210	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TthHC11_22230	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TthHC11_22240	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_22270	COG1028	Short-chain dehydrogenase reductase Sdr
TthHC11_22300	COG1175	transmembrane transport
TthHC11_22320	COG2723	6-phospho-beta-galactosidase activity
TthHC11_22330	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthHC11_22370	COG1233	COG1233 Phytoene dehydrogenase and related
TthHC11_22380	COG0702	epimerase
TthHC11_22460	COG1562	ergosterol biosynthetic process
TthHC11_22480	COG2124	cytochrome p450
TthHC11_22530	COG1487	ribonuclease activity
TthHC11_22550	COG1304	FMN binding
TthHC11_22590	COG1085	galactose-1-phosphate uridylyltransferase
TthHC11_22600	COG3345	alpha-galactosidase
TthHC11_22700	COG1475	DNA binding
TthHC11_22710	COG1192	Involved in chromosome partitioning
TthHC11_22800	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthHC11_22910	COG2814	Major facilitator Superfamily
TthHC11_22930	COG0584	glycerophosphoryl diester phosphodiesterase
TthHC11_22950	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TthHC11_t00350	COG0544	peptidyl-prolyl cis-trans isomerase activity