locus-tag	class	description
TtJL18_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TtJL18_0002	COG0592	DNA-directed DNA polymerase activity
TtJL18_0003	COG0148	phosphopyruvate hydratase activity
TtJL18_0004	COG0469	pyruvate kinase activity
TtJL18_0006	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TtJL18_0007	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TtJL18_0009	COG1842	Phage shock protein A
TtJL18_0015	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TtJL18_0016	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TtJL18_0019	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TtJL18_0021	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TtJL18_0022	COG1278	Cold shock
TtJL18_0024	COG1653	transport
TtJL18_0027	COG0033	Phosphoglucomutase
TtJL18_0030	COG2814	Major facilitator Superfamily
TtJL18_0032	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TtJL18_0032	COG0517	IMP dehydrogenase activity
TtJL18_0033	COG1950	PFAM Membrane protein of
TtJL18_0034	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TtJL18_0036	COG0181	hydroxymethylbilane synthase activity
TtJL18_0038	COG0285	dihydrofolate synthase activity
TtJL18_0039	COG0436	Aminotransferase
TtJL18_0040	COG0521	Mo-molybdopterin cofactor biosynthetic process
TtJL18_0045	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TtJL18_0046	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TtJL18_0047	COG1993	acr, cog1993
TtJL18_0048	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TtJL18_0050	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TtJL18_0052	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TtJL18_0053	COG1335	isochorismatase
TtJL18_0054	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TtJL18_0057	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TtJL18_0058	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TtJL18_0060	COG0242	peptide deformylase activity
TtJL18_0061	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
TtJL18_0062	COG1660	Displays ATPase and GTPase activities
TtJL18_0063	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TtJL18_0072	COG1845	cytochrome c oxidase, subunit III
TtJL18_0072	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TtJL18_0074	COG0109	protoheme IX farnesyltransferase activity
TtJL18_0074	COG1612	heme a metabolic process
TtJL18_0077	COG0343	queuine tRNA-ribosyltransferase activity
TtJL18_0078	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TtJL18_0079	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TtJL18_0090	COG1940	carbohydrate kinase activity
TtJL18_0092	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TtJL18_0093	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TtJL18_0094	COG0589	response to stress
TtJL18_0095	COG1611	Belongs to the LOG family
TtJL18_0097	COG1011	Hydrolase
TtJL18_0098	COG0632	four-way junction helicase activity
TtJL18_0099	COG1024	Enoyl-CoA hydratase
TtJL18_0101	COG0508	dehydrogenase complex catalyzes the overall conversion of
TtJL18_0103	COG1404	Belongs to the peptidase S8 family
TtJL18_0105	COG0137	argininosuccinate synthase activity
TtJL18_0106	COG0165	Argininosuccinate lyase
TtJL18_0110	COG0505	Belongs to the CarA family
TtJL18_0112	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TtJL18_0113	COG0166	Belongs to the GPI family
TtJL18_0115	COG0714	Associated with various cellular activities
TtJL18_0118	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TtJL18_0119	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TtJL18_0120	COG0459	protein refolding
TtJL18_0121	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TtJL18_0122	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TtJL18_0124	COG0778	Nitroreductase
TtJL18_0125	COG1388	LysM domain
TtJL18_0125	COG0791	NLP P60 protein
TtJL18_0127	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TtJL18_0128	COG2814	Major facilitator Superfamily
TtJL18_0129	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TtJL18_0131	COG0573	inorganic phosphate transmembrane transporter activity
TtJL18_0132	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TtJL18_0133	COG0482	sulfurtransferase activity
TtJL18_0135	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TtJL18_0136	COG0735	belongs to the Fur family
TtJL18_0139	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TtJL18_0144	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TtJL18_0145	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TtJL18_0146	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TtJL18_0147	COG0250	Participates in transcription elongation, termination and antitermination
TtJL18_0148	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
TtJL18_0149	COG0081	regulation of translation
TtJL18_0151	COG0360	Binds together with S18 to 16S ribosomal RNA
TtJL18_0152	COG0629	single-stranded DNA binding
TtJL18_0153	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TtJL18_0154	COG0359	binds to the 23S rRNA
TtJL18_0156	COG0300	oxidoreductase activity
TtJL18_0157	COG0321	lipoyl(octanoyl) transferase activity
TtJL18_0158	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TtJL18_0166	COG1476	TRANSCRIPTIONal
TtJL18_0169	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TtJL18_0172	COG1598	PFAM Uncharacterised protein family UPF0150
TtJL18_0173	COG0022	dehydrogenase e1 component
TtJL18_0174	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TtJL18_0175	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TtJL18_0180	COG2226	methyltransferase
TtJL18_0181	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TtJL18_0184	COG1187	pseudouridine synthase activity
TtJL18_0186	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TtJL18_0187	COG0686	Belongs to the AlaDH PNT family
TtJL18_0189	COG1461	Dihydroxyacetone kinase
TtJL18_0192	COG4591	ABC-type transport system involved in lipoprotein release permease component
TtJL18_0193	COG0222	ribosome binding
TtJL18_0194	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TtJL18_0196	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
TtJL18_0197	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TtJL18_0198	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TtJL18_0200	COG0697	spore germination
TtJL18_0203	COG0243	molybdopterin cofactor binding
TtJL18_0204	COG2272	Belongs to the type-B carboxylesterase lipase family
TtJL18_0205	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TtJL18_0207	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TtJL18_0213	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TtJL18_0215	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TtJL18_0221	COG0508	dehydrogenase complex catalyzes the overall conversion of
TtJL18_0222	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
TtJL18_0223	COG0583	DNA-binding transcription factor activity
TtJL18_0224	COG0631	protein serine/threonine phosphatase activity
TtJL18_0225	COG0105	UTP biosynthetic process
TtJL18_0231	COG1278	Cold shock
TtJL18_0232	COG0484	heat shock protein binding
TtJL18_0233	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TtJL18_0234	COG1968	undecaprenyl-diphosphatase activity
TtJL18_0235	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TtJL18_0236	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TtJL18_0239	COG1309	transcriptional regulator
TtJL18_0240	COG4242	Belongs to the peptidase S51 family
TtJL18_0243	COG0802	atpase or kinase
TtJL18_0245	COG0539	negative regulation of cytoplasmic translation
TtJL18_0246	COG0495	leucyl-tRNA aminoacylation
TtJL18_0261	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TtJL18_0262	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TtJL18_0263	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TtJL18_0264	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TtJL18_0269	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TtJL18_0276	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TtJL18_0277	COG0825	malonyl-CoA metabolic process
TtJL18_0280	COG0437	4 iron, 4 sulfur cluster binding
TtJL18_0287	COG3706	GGDEF domain
TtJL18_0288	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TtJL18_0289	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TtJL18_0293	COG0438	transferase activity, transferring glycosyl groups
TtJL18_0296	COG1185	polyribonucleotide nucleotidyltransferase activity
TtJL18_0297	COG3118	belongs to the thioredoxin family
TtJL18_0298	COG0416	fatty acid biosynthetic process
TtJL18_0300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TtJL18_0302	COG0284	orotidine-5'-phosphate decarboxylase activity
TtJL18_0303	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TtJL18_0305	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TtJL18_0309	COG0822	iron-sulfur transferase activity
TtJL18_0310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TtJL18_0313	COG2132	Multicopper oxidase
TtJL18_0318	COG2226	methyltransferase
TtJL18_0321	COG2205	protein histidine kinase activity
TtJL18_0322	COG0745	RESPONSE REGULATOR receiver
TtJL18_0326	COG2217	Heavy metal translocating P-type atpase
TtJL18_0327	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TtJL18_0329	COG0668	transmembrane transport
TtJL18_0331	COG0432	Pfam Uncharacterised protein family UPF0047
TtJL18_0340	COG1489	DNA binding
TtJL18_0344	COG1115	amino acid carrier protein
TtJL18_0346	COG0442	prolyl-tRNA aminoacylation
TtJL18_0348	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
TtJL18_0349	COG0049	tRNA binding
TtJL18_0350	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TtJL18_0351	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TtJL18_0352	COG0051	transcription antitermination factor activity, RNA binding
TtJL18_0353	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
TtJL18_0354	COG0088	Forms part of the polypeptide exit tunnel
TtJL18_0355	COG0089	rRNA binding
TtJL18_0356	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TtJL18_0357	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TtJL18_0358	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
TtJL18_0359	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TtJL18_0360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TtJL18_0361	COG0255	Belongs to the universal ribosomal protein uL29 family
TtJL18_0362	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
TtJL18_0364	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
TtJL18_0365	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
TtJL18_0366	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TtJL18_0367	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TtJL18_0368	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TtJL18_0369	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
TtJL18_0370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TtJL18_0371	COG1841	ribosomal large subunit assembly
TtJL18_0372	COG0200	Binds to the 23S rRNA
TtJL18_0373	COG0201	protein transport
TtJL18_0374	COG0563	adenylate kinase activity
TtJL18_0376	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TtJL18_0377	COG0257	Belongs to the bacterial ribosomal protein bL36 family
TtJL18_0378	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TtJL18_0379	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TtJL18_0380	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TtJL18_0381	COG0202	RNA polymerase activity
TtJL18_0382	COG0203	ribosomal protein L17
TtJL18_0391	COG0142	geranyltranstransferase activity
TtJL18_0392	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TtJL18_0395	COG1175	transmembrane transport
TtJL18_0396	COG3833	ABC-type maltose transport systems, permease component
TtJL18_0399	COG0366	Alpha amylase catalytic
TtJL18_0400	COG1193	negative regulation of DNA recombination
TtJL18_0401	COG1611	Belongs to the LOG family
TtJL18_0402	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TtJL18_0403	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TtJL18_0404	COG3706	GGDEF domain
TtJL18_0405	COG1166	arginine decarboxylase activity
TtJL18_0408	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TtJL18_0409	COG0006	proline dipeptidase activity
TtJL18_0411	COG0747	negative chemotaxis
TtJL18_0412	COG0601	transmembrane transport
TtJL18_0413	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TtJL18_0414	COG0101	tRNA pseudouridine synthase activity
TtJL18_0415	COG3842	ATPase activity
TtJL18_0417	COG1840	ABC-type Fe3 transport system, periplasmic component
TtJL18_0420	COG1764	response to oxidative stress
TtJL18_0422	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TtJL18_0423	COG2897	thiosulfate sulfurtransferase activity
TtJL18_0424	COG0071	Belongs to the small heat shock protein (HSP20) family
TtJL18_0425	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TtJL18_0426	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TtJL18_0427	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TtJL18_0428	COG0537	adenosine 5'-monophosphoramidase activity
TtJL18_0433	COG1011	Hydrolase
TtJL18_0434	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TtJL18_0438	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TtJL18_0439	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TtJL18_0440	COG0823	Involved in the tonB-independent uptake of proteins
TtJL18_0440	COG1506	peptidase
TtJL18_0440	COG4946	Tricorn protease homolog
TtJL18_0445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TtJL18_0446	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TtJL18_0447	COG0113	porphobilinogen synthase activity
TtJL18_0450	COG0631	protein serine/threonine phosphatase activity
TtJL18_0451	COG0515	serine threonine protein kinase
TtJL18_0451	COG2815	serine threonine protein kinase
TtJL18_0456	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TtJL18_0457	COG0193	aminoacyl-tRNA hydrolase activity
TtJL18_0458	COG1181	Belongs to the D-alanine--D-alanine ligase family
TtJL18_0459	COG0187	DNA topoisomerase II activity
TtJL18_0462	COG0732	type I restriction modification DNA specificity domain
TtJL18_0462	COG0827	DNA restriction-modification system
TtJL18_0463	COG0156	8-amino-7-oxononanoate synthase activity
TtJL18_0466	COG0506	proline dehydrogenase activity
TtJL18_0467	COG1012	belongs to the aldehyde dehydrogenase family
TtJL18_0468	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TtJL18_0469	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TtJL18_0475	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TtJL18_0477	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TtJL18_0478	COG2385	sporulation resulting in formation of a cellular spore
TtJL18_0479	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TtJL18_0481	COG0194	GDP metabolic process
TtJL18_0482	COG1758	RNA polymerase activity
TtJL18_0483	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TtJL18_0484	COG1438	arginine binding
TtJL18_0485	COG2095	MarC family integral membrane protein
TtJL18_0486	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TtJL18_0487	COG0328	RNA-DNA hybrid ribonuclease activity
TtJL18_0489	COG4274	PFAM GYD family protein
TtJL18_0490	COG4636	protein conserved in cyanobacteria
TtJL18_0491	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TtJL18_0491	COG0519	Catalyzes the synthesis of GMP from XMP
TtJL18_0494	COG1854	S-ribosylhomocysteine lyase activity
TtJL18_0495	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TtJL18_0496	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TtJL18_0497	COG0322	excinuclease ABC activity
TtJL18_0499	COG2050	protein possibly involved in aromatic compounds catabolism
TtJL18_0504	COG0590	tRNA wobble adenosine to inosine editing
TtJL18_0504	COG0037	tRNA processing
TtJL18_0507	COG0538	isocitrate dehydrogenase activity
TtJL18_0508	COG0557	exoribonuclease II activity
TtJL18_0511	COG0585	pseudouridine synthase activity
TtJL18_0515	COG0604	alcohol dehydrogenase
TtJL18_0517	COG0497	DNA recombination
TtJL18_0518	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TtJL18_0521	COG0116	Belongs to the methyltransferase superfamily
TtJL18_0522	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TtJL18_0523	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TtJL18_0525	COG0047	phosphoribosylformylglycinamidine synthase activity
TtJL18_0527	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TtJL18_0530	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TtJL18_0538	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TtJL18_0541	COG3850	Histidine kinase
TtJL18_0541	COG5002	protein histidine kinase activity
TtJL18_0543	COG1272	protein, Hemolysin III
TtJL18_0544	COG0574	Belongs to the PEP-utilizing enzyme family
TtJL18_0544	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TtJL18_0545	COG0714	Associated with various cellular activities
TtJL18_0546	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TtJL18_0547	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TtJL18_0549	COG1714	RDD family
TtJL18_0550	COG0616	signal peptide processing
TtJL18_0552	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TtJL18_0553	COG0443	Heat shock 70 kDa protein
TtJL18_0554	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TtJL18_0555	COG0484	heat shock protein binding
TtJL18_0556	COG0789	Transcriptional regulator
TtJL18_0557	COG0542	response to heat
TtJL18_0565	COG3118	belongs to the thioredoxin family
TtJL18_0569	COG0490	domain, Protein
TtJL18_0570	COG0475	glutathione-regulated potassium exporter activity
TtJL18_0573	COG2239	Acts as a magnesium transporter
TtJL18_0574	COG0475	glutathione-regulated potassium exporter activity
TtJL18_0576	COG0305	Participates in initiation and elongation during chromosome replication
TtJL18_0577	COG0840	transmembrane signaling receptor activity
TtJL18_0578	COG0069	glutamate synthase activity
TtJL18_0578	COG0070	glutamate synthase
TtJL18_0578	COG0067	glutamate synthase
TtJL18_0581	COG0504	CTP synthase activity
TtJL18_0582	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TtJL18_0583	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TtJL18_0584	COG0318	PFAM AMP-dependent synthetase and ligase
TtJL18_0590	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TtJL18_0591	COG2009	succinate dehydrogenase
TtJL18_0594	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TtJL18_0595	COG0017	Asparaginyl-tRNA synthetase
TtJL18_0598	COG0084	hydrolase, TatD family'
TtJL18_0599	COG0427	acetyl-CoA hydrolase
TtJL18_0600	COG0686	Belongs to the AlaDH PNT family
TtJL18_0601	COG1494	fructose-1,6-bisphosphatase
TtJL18_0602	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TtJL18_0602	COG0140	phosphoribosyl-ATP diphosphatase activity
TtJL18_0603	COG0107	imidazoleglycerol-phosphate synthase activity
TtJL18_0605	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TtJL18_0607	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TtJL18_0609	COG2045	Belongs to the ComB family
TtJL18_0610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TtJL18_0611	COG1136	(ABC) transporter
TtJL18_0612	COG0813	purine-nucleoside phosphorylase activity
TtJL18_0613	COG1024	Enoyl-CoA hydratase
TtJL18_0616	COG3360	Dodecin
TtJL18_0617	COG0318	PFAM AMP-dependent synthetase and ligase
TtJL18_0623	COG3842	ATPase activity
TtJL18_0624	COG2010	Cytochrome c
TtJL18_0628	COG3258	Cytochrome c
TtJL18_0629	COG2010	Cytochrome c
TtJL18_0630	COG0737	Belongs to the 5'-nucleotidase family
TtJL18_0631	COG2010	Cytochrome c
TtJL18_0632	COG3258	Cytochrome c
TtJL18_0635	COG0446	pyridine nucleotide-disulphide oxidoreductase
TtJL18_0637	COG3258	Cytochrome c
TtJL18_0638	COG0785	Cytochrome C biogenesis protein
TtJL18_0639	COG4133	protoheme IX ABC transporter activity
TtJL18_0640	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TtJL18_0641	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TtJL18_0643	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TtJL18_0644	COG1138	Cytochrome C-type biogenesis protein
TtJL18_0645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TtJL18_0646	COG4235	cytochrome complex assembly
TtJL18_0646	COG3088	subunit of a heme lyase
TtJL18_0648	COG0723	plastoquinol--plastocyanin reductase activity
TtJL18_0649	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TtJL18_0651	COG0268	Binds directly to 16S ribosomal RNA
TtJL18_0654	COG0083	homoserine kinase activity
TtJL18_0655	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TtJL18_0655	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TtJL18_0656	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TtJL18_0657	COG1160	GTP binding
TtJL18_0660	COG0736	holo-[acyl-carrier-protein] synthase activity
TtJL18_0661	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TtJL18_0661	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TtJL18_0662	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TtJL18_0663	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TtJL18_0664	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TtJL18_0665	COG1450	Type ii and iii secretion system protein
TtJL18_0670	COG0473	3-isopropylmalate dehydrogenase activity
TtJL18_0676	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TtJL18_0681	COG1752	Esterase of the alpha-beta hydrolase superfamily
TtJL18_0682	COG0681	Belongs to the peptidase S26 family
TtJL18_0683	COG1556	Lactate utilization protein
TtJL18_0684	COG1139	Iron-sulfur cluster binding protein
TtJL18_0685	COG0247	lactate metabolic process
TtJL18_0686	COG2205	protein histidine kinase activity
TtJL18_0690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TtJL18_0693	COG1324	tolerance protein
TtJL18_0694	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TtJL18_0695	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TtJL18_0696	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TtJL18_0697	COG2197	response regulator
TtJL18_0700	COG0776	regulation of translation
TtJL18_0702	COG1515	deoxyribonuclease V activity
TtJL18_0704	COG1482	cell wall glycoprotein biosynthetic process
TtJL18_0705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TtJL18_0706	COG0372	Belongs to the citrate synthase family
TtJL18_0707	COG1132	(ABC) transporter
TtJL18_0708	COG1132	(ABC) transporter
TtJL18_0709	COG0285	dihydrofolate synthase activity
TtJL18_0713	COG0747	negative chemotaxis
TtJL18_0717	COG0559	Belongs to the binding-protein-dependent transport system permease family
TtJL18_0719	COG0174	glutamine synthetase
TtJL18_0720	COG0737	Belongs to the 5'-nucleotidase family
TtJL18_0724	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TtJL18_0725	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TtJL18_0726	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TtJL18_0727	COG0788	formyltetrahydrofolate deformylase activity
TtJL18_0728	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TtJL18_0734	COG1994	Peptidase M50
TtJL18_0734	COG0517	IMP dehydrogenase activity
TtJL18_0736	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TtJL18_0737	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TtJL18_0738	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TtJL18_0742	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TtJL18_0745	COG0746	molybdenum cofactor guanylyltransferase activity
TtJL18_0746	COG1129	ABC transporter
TtJL18_0750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TtJL18_0751	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TtJL18_0752	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TtJL18_0752	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TtJL18_0753	COG0793	Belongs to the peptidase S41A family
TtJL18_0754	COG2884	Cell division ATP-binding protein ftsE
TtJL18_0755	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TtJL18_0759	COG0420	3'-5' exonuclease activity
TtJL18_0760	COG0419	ATPase involved in DNA repair
TtJL18_0762	COG0728	peptidoglycan biosynthetic process
TtJL18_0764	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TtJL18_0766	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TtJL18_0771	COG1269	ATP hydrolysis coupled proton transport
TtJL18_0773	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TtJL18_0774	COG1527	subunit (C
TtJL18_0775	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TtJL18_0776	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TtJL18_0777	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TtJL18_0778	COG1394	ATPase activity, coupled to movement of substances
TtJL18_0781	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TtJL18_0782	COG0612	Peptidase, M16
TtJL18_0783	COG0612	Peptidase, M16
TtJL18_0784	COG0697	spore germination
TtJL18_0785	COG1250	3-hydroxyacyl-CoA dehydrogenase
TtJL18_0787	COG0358	DNA primase activity
TtJL18_0791	COG1205	dead DEAH box helicase
TtJL18_0791	COG1111	helicase
TtJL18_0792	COG0393	Putative heavy-metal-binding
TtJL18_0796	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TtJL18_0797	COG0653	protein targeting
TtJL18_0798	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TtJL18_0799	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TtJL18_0800	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TtJL18_0804	COG1733	regulation of RNA biosynthetic process
TtJL18_0805	COG2894	cell division
TtJL18_0806	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TtJL18_0807	COG0772	Belongs to the SEDS family
TtJL18_0808	COG3842	ATPase activity
TtJL18_0809	COG1176	ABC-type spermidine putrescine transport system, permease component I
TtJL18_0810	COG1177	transmembrane transport
TtJL18_0811	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TtJL18_0813	COG0129	dihydroxy-acid dehydratase activity
TtJL18_0814	COG0300	oxidoreductase activity
TtJL18_0817	COG0473	3-isopropylmalate dehydrogenase activity
TtJL18_0818	COG0066	3-isopropylmalate dehydratase activity
TtJL18_0819	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TtJL18_0821	COG0544	peptidyl-prolyl cis-trans isomerase activity
TtJL18_0822	COG4974	Belongs to the 'phage' integrase family
TtJL18_0825	COG0180	Tryptophanyl-tRNA synthetase
TtJL18_0837	COG0492	ferredoxin-NADP+ reductase activity
TtJL18_0838	COG0028	Belongs to the TPP enzyme family
TtJL18_0839	COG0440	acetolactate synthase activity
TtJL18_0840	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TtJL18_0843	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TtJL18_0846	COG1131	(ABC) transporter
TtJL18_0852	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TtJL18_0856	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TtJL18_0858	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TtJL18_0859	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TtJL18_0865	COG0768	penicillin binding
TtJL18_0868	COG0424	maF-like protein
TtJL18_0870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TtJL18_0871	COG0012	GTP binding
TtJL18_0875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TtJL18_0876	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TtJL18_0878	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TtJL18_0881	COG2313	pseudouridylate synthase activity
TtJL18_0882	COG1426	Protein conserved in bacteria
TtJL18_0883	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TtJL18_0884	COG0569	domain protein
TtJL18_0885	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TtJL18_0887	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TtJL18_0888	COG0765	amino acid transport
TtJL18_0889	COG0525	valine-tRNA ligase activity
TtJL18_0891	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TtJL18_0893	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TtJL18_0894	COG0134	indole-3-glycerol-phosphate synthase activity
TtJL18_0895	COG1752	Esterase of the alpha-beta hydrolase superfamily
TtJL18_0900	COG2873	o-acetylhomoserine
TtJL18_0904	COG2309	aminopeptidase activity
TtJL18_0907	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TtJL18_0907	COG1796	DNA polymerase
TtJL18_0908	COG1573	uracil-dna glycosylase
TtJL18_0909	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TtJL18_0911	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TtJL18_0912	COG2086	electron transfer activity
TtJL18_0913	COG1960	acyl-CoA dehydrogenase activity
TtJL18_0914	COG5002	protein histidine kinase activity
TtJL18_0915	COG0745	RESPONSE REGULATOR receiver
TtJL18_0916	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TtJL18_0917	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TtJL18_0917	COG0517	IMP dehydrogenase activity
TtJL18_0919	COG0589	response to stress
TtJL18_0920	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TtJL18_0921	COG1185	polyribonucleotide nucleotidyltransferase activity
TtJL18_0922	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TtJL18_0923	COG2814	Major facilitator Superfamily
TtJL18_0925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TtJL18_0926	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TtJL18_0928	COG1100	Small GTP-binding protein
TtJL18_0931	COG0010	Belongs to the arginase family
TtJL18_0935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TtJL18_0936	COG0511	ligase activity, forming carbon-carbon bonds
TtJL18_0937	COG0439	Biotin carboxylase
TtJL18_0939	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TtJL18_0940	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TtJL18_0941	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TtJL18_0943	COG0247	lactate metabolic process
TtJL18_0943	COG2181	nitrate reductase activity
TtJL18_0945	COG0861	Integral membrane protein TerC family
TtJL18_0946	COG2819	hydrolase of the alpha beta superfamily
TtJL18_0947	COG0039	L-malate dehydrogenase activity
TtJL18_0949	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TtJL18_0950	COG0438	transferase activity, transferring glycosyl groups
TtJL18_0962	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TtJL18_0963	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TtJL18_0964	COG0133	tryptophan synthase activity
TtJL18_0965	COG0159	tryptophan synthase activity
TtJL18_0967	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TtJL18_0970	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TtJL18_0974	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TtJL18_0975	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TtJL18_0976	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TtJL18_0977	COG0772	Belongs to the SEDS family
TtJL18_0978	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TtJL18_0979	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TtJL18_0981	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TtJL18_0982	COG0768	penicillin binding
TtJL18_0984	COG0275	rRNA processing
TtJL18_0985	COG2001	Belongs to the MraZ family
TtJL18_0987	COG0254	rRNA binding
TtJL18_0988	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TtJL18_0990	COG0739	heme binding
TtJL18_0992	COG0006	proline dipeptidase activity
TtJL18_0993	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TtJL18_0994	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TtJL18_0995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TtJL18_0996	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TtJL18_0996	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TtJL18_0998	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TtJL18_0998	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TtJL18_0999	COG2304	oxidoreductase activity
TtJL18_1000	COG2239	Acts as a magnesium transporter
TtJL18_1001	COG1397	ADP-ribosylglycohydrolase
TtJL18_1002	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TtJL18_1004	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TtJL18_1005	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TtJL18_1005	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TtJL18_1009	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TtJL18_1011	COG4864	UPF0365 protein
TtJL18_1013	COG1702	phosphate starvation-inducible protein PhoH
TtJL18_1014	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TtJL18_1015	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TtJL18_1017	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TtJL18_1018	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
TtJL18_1019	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TtJL18_1021	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TtJL18_1024	COG0228	four-way junction DNA binding
TtJL18_1025	COG1837	Belongs to the UPF0109 family
TtJL18_1026	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TtJL18_1027	COG0336	Belongs to the RNA methyltransferase TrmD family
TtJL18_1028	COG0335	large ribosomal subunit rRNA binding
TtJL18_1029	COG2197	response regulator
TtJL18_1030	COG1760	l-serine dehydratase
TtJL18_1031	COG2897	thiosulfate sulfurtransferase activity
TtJL18_1036	COG0842	Transport permease protein
TtJL18_1037	COG1131	(ABC) transporter
TtJL18_1038	COG1309	transcriptional regulator
TtJL18_1039	COG0577	efflux transmembrane transporter activity
TtJL18_1039	COG1136	(ABC) transporter
TtJL18_1040	COG1136	(ABC) transporter
TtJL18_1041	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TtJL18_1044	COG2205	protein histidine kinase activity
TtJL18_1045	COG0745	RESPONSE REGULATOR receiver
TtJL18_1048	COG0210	DNA helicase
TtJL18_1051	COG1012	belongs to the aldehyde dehydrogenase family
TtJL18_1057	COG1846	Transcriptional regulator
TtJL18_1058	COG0477	Major facilitator Superfamily
TtJL18_1059	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
TtJL18_1060	COG0183	Belongs to the thiolase family
TtJL18_1061	COG1331	Highly conserved protein containing a thioredoxin domain
TtJL18_1065	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TtJL18_1066	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TtJL18_1068	COG1733	regulation of RNA biosynthetic process
TtJL18_1069	COG1980	fructose-bisphosphate aldolase activity
TtJL18_1076	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TtJL18_1078	COG3396	Phenylacetate-CoA oxygenase
TtJL18_1082	COG1012	belongs to the aldehyde dehydrogenase family
TtJL18_1082	COG2030	dehydratase
TtJL18_1084	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TtJL18_1085	COG2050	protein possibly involved in aromatic compounds catabolism
TtJL18_1086	COG0410	ABC transporter
TtJL18_1087	COG0411	ABC transporter
TtJL18_1088	COG0559	Belongs to the binding-protein-dependent transport system permease family
TtJL18_1091	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TtJL18_1092	COG2368	4-hydroxyphenylacetate
TtJL18_1093	COG1012	belongs to the aldehyde dehydrogenase family
TtJL18_1095	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TtJL18_1097	COG3769	mannosylglycerate metabolic process
TtJL18_1100	COG1136	(ABC) transporter
TtJL18_1105	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TtJL18_1106	COG1307	EDD domain protein, DegV family
TtJL18_1107	COG1307	EDD domain protein, DegV family
TtJL18_1108	COG1490	D-aminoacyl-tRNA deacylase activity
TtJL18_1109	COG3239	Fatty acid desaturase
TtJL18_1110	COG0149	triose-phosphate isomerase activity
TtJL18_1126	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TtJL18_1128	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TtJL18_1129	COG0138	bifunctional purine biosynthesis protein purh
TtJL18_1130	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TtJL18_1131	COG0742	ribosomal rna small subunit methyltransferase
TtJL18_1134	COG0237	dephospho-CoA kinase activity
TtJL18_1135	COG0617	tRNA 3'-terminal CCA addition
TtJL18_1136	COG1355	regulation of microtubule-based process
TtJL18_1137	COG0557	exoribonuclease II activity
TtJL18_1139	COG0824	Thioesterase
TtJL18_1140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TtJL18_1141	COG0126	phosphoglycerate kinase activity
TtJL18_1143	COG1268	BioY protein
TtJL18_1144	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TtJL18_1144	COG3153	acetyltransferase
TtJL18_1145	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TtJL18_1148	COG1196	nuclear chromosome segregation
TtJL18_1152	COG2738	Putative neutral zinc metallopeptidase
TtJL18_1154	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TtJL18_1155	COG0215	cysteine-tRNA ligase activity
TtJL18_1156	COG1960	acyl-CoA dehydrogenase activity
TtJL18_1157	COG0183	Belongs to the thiolase family
TtJL18_1158	COG1024	Enoyl-CoA hydratase
TtJL18_1158	COG1250	3-hydroxyacyl-CoA dehydrogenase
TtJL18_1159	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
TtJL18_1161	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TtJL18_1162	COG0438	transferase activity, transferring glycosyl groups
TtJL18_1164	COG1216	Glycosyl transferase, family 2
TtJL18_1166	COG1215	transferase activity, transferring glycosyl groups
TtJL18_1169	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TtJL18_1169	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TtJL18_1170	COG1811	Na channel or pump
TtJL18_1171	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TtJL18_1172	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TtJL18_1173	COG4948	Mandelate Racemase Muconate Lactonizing
TtJL18_1175	COG0402	S-adenosylhomocysteine deaminase activity
TtJL18_1183	COG0494	nUDIX hydrolase
TtJL18_1186	COG0052	Belongs to the universal ribosomal protein uS2 family
TtJL18_1187	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TtJL18_1188	COG0528	UMP kinase activity
TtJL18_1189	COG0233	cytoplasmic translational termination
TtJL18_1190	COG0575	Belongs to the CDS family
TtJL18_1191	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TtJL18_1192	COG0750	zinc metalloprotease
TtJL18_1193	COG0463	Glycosyl transferase, family 2
TtJL18_1195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TtJL18_1196	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TtJL18_1197	COG2359	stage V sporulation protein S
TtJL18_1199	COG2137	regulation of response to DNA damage stimulus
TtJL18_1204	COG2766	serine protein kinase
TtJL18_1205	COG2718	Belongs to the UPF0229 family
TtJL18_1206	COG2719	SpoVR family
TtJL18_1207	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TtJL18_1208	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TtJL18_1211	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TtJL18_1213	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TtJL18_1214	COG1994	Peptidase M50
TtJL18_1219	COG0517	IMP dehydrogenase activity
TtJL18_1222	COG1674	ftsk spoiiie
TtJL18_1223	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TtJL18_1224	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TtJL18_1225	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TtJL18_1226	COG4651	solute:proton antiporter activity
TtJL18_1226	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TtJL18_1227	COG0217	transcriptional regulatory protein
TtJL18_1229	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TtJL18_1235	COG5002	protein histidine kinase activity
TtJL18_1235	COG2176	DNA-directed DNA polymerase activity
TtJL18_1236	COG0151	Belongs to the GarS family
TtJL18_1237	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TtJL18_1239	COG0179	Fumarylacetoacetate (FAA) hydrolase
TtJL18_1240	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TtJL18_1247	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TtJL18_1248	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TtJL18_1249	COG2353	YceI-like domain
TtJL18_1250	COG2514	catechol 2,3-dioxygenase activity
TtJL18_1251	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TtJL18_1252	COG0287	Prephenate dehydrogenase
TtJL18_1254	COG0277	FAD linked oxidase domain protein
TtJL18_1258	COG0009	L-threonylcarbamoyladenylate synthase
TtJL18_1259	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TtJL18_1261	COG0456	acetyltransferase
TtJL18_1262	COG1960	acyl-CoA dehydrogenase activity
TtJL18_1266	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TtJL18_1267	COG0730	response to heat
TtJL18_1273	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TtJL18_1275	COG0167	dihydroorotate dehydrogenase activity
TtJL18_1278	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TtJL18_1279	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
TtJL18_1280	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TtJL18_1281	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TtJL18_1282	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TtJL18_1283	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TtJL18_1285	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TtJL18_1288	COG1063	alcohol dehydrogenase
TtJL18_1291	COG2873	o-acetylhomoserine
TtJL18_1292	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TtJL18_1295	COG1073	alpha beta
TtJL18_1296	COG0405	Gamma-glutamyltransferase
TtJL18_1301	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_1304	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TtJL18_1307	COG0481	GTPase activity
TtJL18_1309	COG1760	l-serine dehydratase
TtJL18_1313	COG0295	cytidine deaminase activity
TtJL18_1321	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TtJL18_1323	COG1316	TRANSCRIPTIONal
TtJL18_1326	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TtJL18_1330	COG1573	uracil-dna glycosylase
TtJL18_1333	COG3842	ATPase activity
TtJL18_1336	COG0124	histidyl-tRNA synthetase
TtJL18_1337	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
TtJL18_1338	COG0384	phenazine biosynthesis protein PhzF
TtJL18_1339	COG0561	phosphatase activity
TtJL18_1340	COG0017	Asparaginyl-tRNA synthetase
TtJL18_1341	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TtJL18_1345	COG4221	oxidoreductase activity
TtJL18_1348	COG0702	epimerase
TtJL18_1356	COG0640	Transcriptional regulator
TtJL18_1357	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TtJL18_1360	COG0779	Required for maturation of 30S ribosomal subunits
TtJL18_1361	COG0195	Participates in both transcription termination and antitermination
TtJL18_1363	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TtJL18_1365	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TtJL18_1365	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TtJL18_1368	COG0318	PFAM AMP-dependent synthetase and ligase
TtJL18_1369	COG0596	Alpha beta hydrolase
TtJL18_1371	COG2030	dehydratase
TtJL18_1373	COG0559	Belongs to the binding-protein-dependent transport system permease family
TtJL18_1376	COG0410	ABC transporter
TtJL18_1377	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_1380	COG0183	Belongs to the thiolase family
TtJL18_1381	COG1940	carbohydrate kinase activity
TtJL18_1391	COG0351	phosphomethylpyrimidine kinase
TtJL18_1392	COG0477	Major facilitator Superfamily
TtJL18_1393	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TtJL18_1395	COG2022	thiamine diphosphate biosynthetic process
TtJL18_1396	COG2104	thiamine diphosphate biosynthetic process
TtJL18_1397	COG0352	thiamine-phosphate diphosphorylase activity
TtJL18_1399	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TtJL18_1400	COG1587	Uroporphyrinogen-III synthase
TtJL18_1401	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TtJL18_1401	COG1648	precorrin-2 dehydrogenase activity
TtJL18_1402	COG0175	sulfate reduction
TtJL18_1403	COG0730	response to heat
TtJL18_1404	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TtJL18_1404	COG1648	precorrin-2 dehydrogenase activity
TtJL18_1405	COG2046	Belongs to the sulfate adenylyltransferase family
TtJL18_1406	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TtJL18_1413	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TtJL18_1414	COG2264	protein methyltransferase activity
TtJL18_1416	COG0489	protein tyrosine kinase activity
TtJL18_1420	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TtJL18_1423	COG1216	Glycosyl transferase, family 2
TtJL18_1424	COG0438	transferase activity, transferring glycosyl groups
TtJL18_1426	COG0438	transferase activity, transferring glycosyl groups
TtJL18_1438	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TtJL18_1439	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TtJL18_1445	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TtJL18_1446	COG1692	metallophosphoesterase
TtJL18_1449	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TtJL18_1451	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TtJL18_1453	COG0646	methionine synthase
TtJL18_1453	COG1410	methionine synthase
TtJL18_1454	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TtJL18_1455	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TtJL18_1456	COG0740	serine-type endopeptidase activity
TtJL18_1457	COG0544	peptidyl-prolyl cis-trans isomerase activity
TtJL18_1461	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TtJL18_1462	COG3870	Protein conserved in bacteria
TtJL18_1464	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TtJL18_1466	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TtJL18_1469	COG1960	acyl-CoA dehydrogenase activity
TtJL18_1470	COG2030	dehydratase
TtJL18_1470	COG1012	belongs to the aldehyde dehydrogenase family
TtJL18_1471	COG0318	PFAM AMP-dependent synthetase and ligase
TtJL18_1472	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_1474	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TtJL18_1475	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TtJL18_1476	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TtJL18_1481	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TtJL18_1482	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TtJL18_1486	COG0683	leucine binding
TtJL18_1488	COG0410	ABC transporter
TtJL18_1493	COG4475	Protein of unknown function (DUF436)
TtJL18_1496	COG3842	ATPase activity
TtJL18_1497	COG0572	uridine kinase
TtJL18_1502	COG0154	amidase activity
TtJL18_1503	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TtJL18_1505	COG2133	pyrroloquinoline quinone binding
TtJL18_1506	COG1063	alcohol dehydrogenase
TtJL18_1508	COG1254	Belongs to the acylphosphatase family
TtJL18_1509	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TtJL18_1512	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TtJL18_1513	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TtJL18_1516	COG0183	Belongs to the thiolase family
TtJL18_1517	COG0114	fumarate hydratase activity
TtJL18_1518	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TtJL18_1519	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TtJL18_1520	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TtJL18_1522	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TtJL18_1523	COG0291	Belongs to the bacterial ribosomal protein bL35 family
TtJL18_1524	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TtJL18_1526	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TtJL18_1526	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TtJL18_1530	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TtJL18_1533	COG0423	glycine-tRNA ligase activity
TtJL18_1534	COG0542	response to heat
TtJL18_1535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TtJL18_1536	COG4956	integral membrane protein (PIN domain superfamily)
TtJL18_1540	COG0039	L-malate dehydrogenase activity
TtJL18_1541	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
TtJL18_1542	COG0527	aspartate kinase activity
TtJL18_1543	COG2813	Specifically methylates the guanine in position
TtJL18_1544	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TtJL18_1548	COG1051	belongs to the nudix hydrolase family
TtJL18_1549	COG0196	riboflavin kinase activity
TtJL18_1550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TtJL18_1551	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TtJL18_1552	COG0509	glycine decarboxylation via glycine cleavage system
TtJL18_1553	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TtJL18_1556	COG0281	malic enzyme
TtJL18_1557	COG2151	metal-sulfur cluster biosynthetic enzyme
TtJL18_1558	COG0861	Integral membrane protein TerC family
TtJL18_1565	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TtJL18_1566	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TtJL18_1567	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TtJL18_1568	COG0789	Transcriptional regulator
TtJL18_1569	COG1414	Transcriptional regulator
TtJL18_1570	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TtJL18_1571	COG0277	FAD linked oxidase domain protein
TtJL18_1572	COG0277	FAD linked oxidase domain protein
TtJL18_1573	COG0247	lactate metabolic process
TtJL18_1578	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TtJL18_1587	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TtJL18_1589	COG0460	homoserine dehydrogenase
TtJL18_1591	COG3744	PilT protein domain protein
TtJL18_1592	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TtJL18_1594	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TtJL18_1596	COG2226	methyltransferase
TtJL18_1597	COG2226	methyltransferase
TtJL18_1598	COG0366	Alpha amylase catalytic
TtJL18_1599	COG3448	diguanylate cyclase activity
TtJL18_1599	COG4175	Glycine betaine
TtJL18_1600	COG4176	ABC-type proline glycine betaine transport system permease component
TtJL18_1602	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
TtJL18_1605	COG0037	tRNA processing
TtJL18_1606	COG2104	thiamine diphosphate biosynthetic process
TtJL18_1607	COG0123	including yeast histone deacetylase and acetoin utilization protein
TtJL18_1608	COG0517	IMP dehydrogenase activity
TtJL18_1611	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TtJL18_1612	COG0601	transmembrane transport
TtJL18_1613	COG0747	negative chemotaxis
TtJL18_1615	COG0492	ferredoxin-NADP+ reductase activity
TtJL18_1620	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_1623	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TtJL18_1624	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TtJL18_1625	COG1104	cysteine desulfurase activity
TtJL18_1626	COG1959	2 iron, 2 sulfur cluster binding
TtJL18_1627	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TtJL18_1628	COG1121	(ABC) transporter
TtJL18_1632	COG0559	Belongs to the binding-protein-dependent transport system permease family
TtJL18_1633	COG1022	Amp-dependent synthetase and ligase
TtJL18_1635	COG0594	ribonuclease P activity
TtJL18_1636	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TtJL18_1637	COG0706	membrane insertase activity
TtJL18_1639	COG2890	protein-(glutamine-N5) methyltransferase activity
TtJL18_1642	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TtJL18_1645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TtJL18_1648	COG0517	IMP dehydrogenase activity
TtJL18_1648	COG0516	GMP reductase activity
TtJL18_1650	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TtJL18_1651	COG0131	Imidazoleglycerol-phosphate dehydratase
TtJL18_1652	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TtJL18_1655	COG0778	Nitroreductase
TtJL18_1662	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TtJL18_1663	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TtJL18_1664	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TtJL18_1666	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TtJL18_1667	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TtJL18_1668	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TtJL18_1669	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TtJL18_1670	COG3335	DDE superfamily endonuclease
TtJL18_1673	COG0564	pseudouridine synthase activity
TtJL18_1674	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TtJL18_1675	COG2255	four-way junction helicase activity
TtJL18_1681	COG1063	alcohol dehydrogenase
TtJL18_1692	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TtJL18_1692	COG1605	Chorismate mutase
TtJL18_1693	COG0805	protein transport
TtJL18_1694	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TtJL18_1695	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TtJL18_1696	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TtJL18_1702	COG0395	ABC-type sugar transport system, permease component
TtJL18_1703	COG1175	transmembrane transport
TtJL18_1706	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TtJL18_1707	COG0792	nuclease activity
TtJL18_1709	COG0492	ferredoxin-NADP+ reductase activity
TtJL18_1710	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_1714	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TtJL18_1716	COG0142	geranyltranstransferase activity
TtJL18_1719	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TtJL18_1720	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TtJL18_1722	COG0297	glycogen (starch) synthase activity
TtJL18_1723	COG2105	PFAM AIG2 family protein
TtJL18_1726	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TtJL18_1727	COG1067	ATP-dependent peptidase activity
TtJL18_1729	COG3706	GGDEF domain
TtJL18_1733	COG0667	Aldo Keto reductase
TtJL18_1739	COG0277	FAD linked oxidase domain protein
TtJL18_1741	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TtJL18_1743	COG0475	glutathione-regulated potassium exporter activity
TtJL18_1743	COG0569	domain protein
TtJL18_1747	COG1708	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
TtJL18_1748	COG1597	lipid kinase activity
TtJL18_1751	COG0123	including yeast histone deacetylase and acetoin utilization protein
TtJL18_1753	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TtJL18_1755	COG0004	ammonium transporteR
TtJL18_1756	COG0347	Belongs to the P(II) protein family
TtJL18_1757	COG1420	regulation of RNA biosynthetic process
TtJL18_1758	COG0314	molybdopterin synthase activity
TtJL18_1761	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TtJL18_1762	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TtJL18_1765	COG0277	FAD linked oxidase domain protein
TtJL18_1772	COG2720	vancomycin resistance protein
TtJL18_1774	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TtJL18_1776	COG0135	phosphoribosylanthranilate isomerase activity
TtJL18_1779	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TtJL18_1783	COG4712	double-strand break repair protein
TtJL18_1785	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TtJL18_1786	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TtJL18_1787	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TtJL18_1788	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TtJL18_1789	COG0649	NAD binding
TtJL18_1790	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TtJL18_1791	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TtJL18_1792	COG1034	ATP synthesis coupled electron transport
TtJL18_1793	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TtJL18_1794	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TtJL18_1795	COG0839	Belongs to the complex I subunit 6 family
TtJL18_1796	COG0713	ATP synthesis coupled electron transport
TtJL18_1797	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TtJL18_1798	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TtJL18_1799	COG1007	ATP synthesis coupled electron transport
TtJL18_1800	COG0018	arginyl-trna synthetase
TtJL18_1801	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TtJL18_1802	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TtJL18_1805	COG2070	2-Nitropropane dioxygenase
TtJL18_1809	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TtJL18_1813	COG0513	Belongs to the DEAD box helicase family
TtJL18_1814	COG0303	'Molybdopterin
TtJL18_1818	COG1121	(ABC) transporter
TtJL18_1819	COG0442	prolyl-tRNA aminoacylation
TtJL18_1820	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TtJL18_1821	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TtJL18_1826	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TtJL18_1833	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TtJL18_1834	COG0758	DNA mediated transformation
TtJL18_1834	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TtJL18_1835	COG3546	catalase activity
TtJL18_1836	COG0583	DNA-binding transcription factor activity
TtJL18_1838	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TtJL18_1839	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TtJL18_1840	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TtJL18_1841	COG0717	Belongs to the dCTP deaminase family
TtJL18_1844	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_1845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TtJL18_1850	COG0515	serine threonine protein kinase
TtJL18_1850	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TtJL18_1852	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TtJL18_1855	COG0704	Plays a role in the regulation of phosphate uptake
TtJL18_1856	COG4191	Histidine kinase
TtJL18_1857	COG0745	RESPONSE REGULATOR receiver
TtJL18_1858	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TtJL18_1860	COG1187	pseudouridine synthase activity
TtJL18_1862	COG1459	type II secretion system
TtJL18_1868	COG2165	general secretion pathway protein
TtJL18_1872	COG2414	aldehyde ferredoxin oxidoreductase
TtJL18_1877	COG1902	pentaerythritol trinitrate reductase activity
TtJL18_1885	COG0315	cyclic pyranopterin monophosphate synthase activity
TtJL18_1887	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TtJL18_1890	COG0477	Major facilitator Superfamily
TtJL18_1891	COG1694	Mazg nucleotide pyrophosphohydrolase
TtJL18_1892	COG1803	Methylglyoxal synthase
TtJL18_1894	COG0301	tRNA thio-modification
TtJL18_1895	COG0154	amidase activity
TtJL18_1896	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TtJL18_1901	COG2154	pterin-4-alpha-carbinolamine dehydratase
TtJL18_1902	COG1607	acyl-coa hydrolase
TtJL18_1904	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TtJL18_1906	COG1840	ABC-type Fe3 transport system, periplasmic component
TtJL18_1909	COG0235	Class ii aldolase
TtJL18_1910	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TtJL18_1911	COG0085	RNA polymerase activity
TtJL18_1913	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TtJL18_1914	COG1077	Cell shape determining protein MreB Mrl
TtJL18_1915	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TtJL18_1915	COG1418	mRNA catabolic process
TtJL18_1916	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TtJL18_1917	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TtJL18_1918	COG1058	Belongs to the CinA family
TtJL18_1918	COG1546	Belongs to the CinA family
TtJL18_1919	COG0354	folic acid binding
TtJL18_1922	COG4948	Mandelate Racemase Muconate Lactonizing
TtJL18_1925	COG1175	transmembrane transport
TtJL18_1927	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TtJL18_1929	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TtJL18_1931	COG1136	(ABC) transporter
TtJL18_1931	COG0577	efflux transmembrane transporter activity
TtJL18_1932	COG4181	ATPase activity
TtJL18_1933	COG0446	pyridine nucleotide-disulphide oxidoreductase
TtJL18_1936	COG0396	ATPase activity
TtJL18_1937	COG0719	Fe-S assembly protein
TtJL18_1938	COG0719	Fe-S assembly protein
TtJL18_1939	COG2146	nitrite reductase [NAD(P)H] activity
TtJL18_1940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
TtJL18_1941	COG0512	Glutamine amidotransferase of anthranilate synthase
TtJL18_1942	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TtJL18_1947	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TtJL18_1948	COG2226	methyltransferase
TtJL18_1953	COG1774	PSP1 C-terminal conserved region
TtJL18_1954	COG0470	DNA polymerase III
TtJL18_1961	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TtJL18_1962	COG0302	gtp cyclohydrolase
TtJL18_1968	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TtJL18_1970	COG0395	ABC-type sugar transport system, permease component
TtJL18_1971	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TtJL18_1973	COG1131	(ABC) transporter
TtJL18_1977	COG0556	nucleotide-excision repair
TtJL18_1978	COG0497	DNA recombination
TtJL18_1979	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TtJL18_1981	COG0445	tRNA wobble uridine modification
TtJL18_1985	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TtJL18_1985	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TtJL18_1986	COG1543	Belongs to the glycosyl hydrolase 57 family
TtJL18_1987	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TtJL18_1988	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TtJL18_1989	COG0189	ligase activity
TtJL18_1992	COG0066	3-isopropylmalate dehydratase activity
TtJL18_1993	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TtJL18_1997	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TtJL18_1998	COG1960	acyl-CoA dehydrogenase activity
TtJL18_1999	COG0163	prenyltransferase activity
TtJL18_2007	COG1668	transmembrane transport
TtJL18_2008	COG4555	ABC transporter
TtJL18_2010	COG2096	Adenosyltransferase
TtJL18_2014	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TtJL18_2015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TtJL18_2018	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TtJL18_2019	COG0723	plastoquinol--plastocyanin reductase activity
TtJL18_2025	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TtJL18_2026	COG1960	acyl-CoA dehydrogenase activity
TtJL18_2028	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TtJL18_2032	COG0393	Putative heavy-metal-binding
TtJL18_2034	COG3956	TIGRFAM MazG family protein
TtJL18_2036	COG0693	protein deglycase activity
TtJL18_2037	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TtJL18_2039	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TtJL18_2040	COG1937	Protein conserved in bacteria
TtJL18_2042	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TtJL18_2042	COG0674	pyruvate-flavodoxin oxidoreductase activity
TtJL18_2043	COG1013	pyruvate-flavodoxin oxidoreductase activity
TtJL18_2044	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TtJL18_2045	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
TtJL18_2046	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TtJL18_2046	COG0072	phenylalanine-tRNA ligase activity
TtJL18_2048	COG0205	6-phosphofructokinase activity
TtJL18_2049	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TtJL18_2051	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TtJL18_2054	COG2333	competence protein COMEC
TtJL18_2054	COG0658	competence protein
TtJL18_2055	COG1475	DNA binding
TtJL18_2056	COG1192	Involved in chromosome partitioning
TtJL18_2057	COG0357	Ribosomal RNA small subunit methyltransferase G
TtJL18_2058	COG0445	tRNA wobble uridine modification
TtJL18_2061	COG1175	transmembrane transport
TtJL18_2062	COG0395	ABC-type sugar transport system, permease component
TtJL18_2063	COG2076	Multidrug Resistance protein
TtJL18_2065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TtJL18_2069	COG1110	DNA topoisomerase II activity
TtJL18_2073	COG0514	ATP-dependent DNA helicase (RecQ)
TtJL18_2076	COG0747	negative chemotaxis
TtJL18_2077	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TtJL18_2079	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TtJL18_2080	COG1012	belongs to the aldehyde dehydrogenase family
TtJL18_2083	COG0395	ABC-type sugar transport system, permease component
TtJL18_2084	COG1175	transmembrane transport
TtJL18_2086	COG1609	Transcriptional regulator
TtJL18_2089	COG0863	Belongs to the N(4) N(6)-methyltransferase family
TtJL18_2094	COG1857	crispr-associated protein
TtJL18_2098	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
TtJL18_2100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
TtJL18_2105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TtJL18_2106	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TtJL18_2109	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
TtJL18_2113	COG1475	DNA binding
TtJL18_2119	COG2329	Antibiotic biosynthesis monooxygenase
TtJL18_2126	COG4974	Belongs to the 'phage' integrase family
TtJL18_2129	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TtJL18_2176	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_2177	COG0318	PFAM AMP-dependent synthetase and ligase
TtJL18_2179	COG2030	dehydratase
TtJL18_2179	COG1012	belongs to the aldehyde dehydrogenase family
TtJL18_2180	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_2182	COG0410	ABC transporter
TtJL18_2183	COG0411	ABC transporter
TtJL18_2187	COG1960	acyl-CoA dehydrogenase activity
TtJL18_2190	COG0559	Belongs to the binding-protein-dependent transport system permease family
TtJL18_2192	COG0318	PFAM AMP-dependent synthetase and ligase
TtJL18_2193	COG0411	ABC transporter
TtJL18_2205	COG2211	Major facilitator Superfamily
TtJL18_2212	COG1797	cobyrinic acid a,c-diamide synthase activity
TtJL18_2213	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
TtJL18_2215	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
TtJL18_2218	COG0588	phosphoglycerate mutase activity
TtJL18_2219	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
TtJL18_2220	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
TtJL18_2229	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TtJL18_2229	COG1648	precorrin-2 dehydrogenase activity
TtJL18_2234	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TtJL18_2237	COG1492	cobalamin metabolic process
TtJL18_2238	COG1785	Belongs to the alkaline phosphatase family
TtJL18_2239	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
TtJL18_2243	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TtJL18_2245	COG0800	Aldolase
TtJL18_2246	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
TtJL18_2248	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TtJL18_2249	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_2252	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_2255	COG1175	transmembrane transport
TtJL18_2258	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TtJL18_2261	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TtJL18_2263	COG1562	ergosterol biosynthetic process
TtJL18_2269	COG0463	Glycosyl transferase, family 2
TtJL18_2271	COG1487	ribonuclease activity
TtJL18_2273	COG1304	FMN binding
TtJL18_2278	COG1085	galactose-1-phosphate uridylyltransferase
TtJL18_2279	COG3345	alpha-galactosidase
TtJL18_2287	COG1475	DNA binding
TtJL18_2288	COG1192	Involved in chromosome partitioning
TtJL18_2298	COG3256	nitric oxide reductase
TtJL18_2301	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TtJL18_2302	COG2010	Cytochrome c
TtJL18_2307	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TtJL18_2312	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TtJL18_2314	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TtJL18_2315	COG1252	NADH dehydrogenase
TtJL18_2318	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
TtJL18_2320	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TtJL18_2322	COG2010	Cytochrome c
TtJL18_2323	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
TtJL18_2324	COG1140	nitrate reductase beta subunit
TtJL18_2326	COG2181	nitrate reductase activity
TtJL18_2333	COG2151	metal-sulfur cluster biosynthetic enzyme
TtJL18_2334	COG2814	Major facilitator Superfamily
TtJL18_2336	COG0584	glycerophosphoryl diester phosphodiesterase
TtJL18_2337	COG1737	Transcriptional regulator
TtJL18_2338	COG0546	phosphoglycolate phosphatase activity
TtJL18_2385	COG0535	radical SAM domain protein
TtJL18_2396	COG0739	heme binding
TtJL18_2424	COG1942	4-Oxalocrotonate Tautomerase
TtJL18_2426	COG2084	Dehydrogenase
TtJL18_2437	COG1028	Short-chain dehydrogenase reductase Sdr
TtJL18_2440	COG3328	transposase activity
TtJL18_2441	COG3181	Tripartite tricarboxylate transporter family receptor
TtJL18_2449	COG3335	DDE superfamily endonuclease
TtJL18_2453	COG1074	ATP-dependent DNA helicase activity
TtJL18_2456	COG1203	CRISPR-associated helicase, Cas3
TtJL18_2468	COG1475	DNA binding
TtJL18_2469	COG1192	Involved in chromosome partitioning
TtJL18_2480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
TtJL18_2488	COG2002	toxin-antitoxin pair type II binding
TtJL18_2503	COG3854	ATPases associated with a variety of cellular activities
TtJL18_2504	COG0497	DNA recombination