locus-tag	class	description
K7H19_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K7H19_00010	COG0592	DNA-directed DNA polymerase activity
K7H19_00015	COG0148	phosphopyruvate hydratase activity
K7H19_00020	COG0469	pyruvate kinase activity
K7H19_00030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7H19_00035	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K7H19_00045	COG1842	Phage shock protein A
K7H19_00070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K7H19_00080	COG0142	geranyltranstransferase activity
K7H19_00095	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K7H19_00100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K7H19_00110	COG0297	glycogen (starch) synthase activity
K7H19_00115	COG2105	PFAM AIG2 family protein
K7H19_00120	COG0745	RESPONSE REGULATOR receiver
K7H19_00130	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K7H19_00135	COG1067	ATP-dependent peptidase activity
K7H19_00155	COG0667	Aldo Keto reductase
K7H19_00180	COG2002	toxin-antitoxin pair type II binding
K7H19_00220	COG0277	FAD linked oxidase domain protein
K7H19_00230	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K7H19_00240	COG0569	domain protein
K7H19_00240	COG0475	glutathione-regulated potassium exporter activity
K7H19_00250	COG0436	Aminotransferase
K7H19_00265	COG1597	lipid kinase activity
K7H19_00280	COG0123	including yeast histone deacetylase and acetoin utilization protein
K7H19_00290	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K7H19_00300	COG0004	ammonium transporteR
K7H19_00305	COG0347	Belongs to the P(II) protein family
K7H19_00310	COG1420	regulation of RNA biosynthetic process
K7H19_00315	COG0314	molybdopterin synthase activity
K7H19_00330	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K7H19_00335	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K7H19_00345	COG0277	FAD linked oxidase domain protein
K7H19_00375	COG1126	abc transporter atp-binding protein
K7H19_00380	COG2720	vancomycin resistance protein
K7H19_00390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K7H19_00395	COG1372	Participates in initiation and elongation during chromosome replication
K7H19_00395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7H19_00400	COG0135	phosphoribosylanthranilate isomerase activity
K7H19_00415	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K7H19_00430	COG4712	double-strand break repair protein
K7H19_00440	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K7H19_00445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7H19_00450	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7H19_00455	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7H19_00460	COG0649	NAD binding
K7H19_00465	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K7H19_00470	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
K7H19_00475	COG1034	ATP synthesis coupled electron transport
K7H19_00480	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K7H19_00485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7H19_00490	COG0839	Belongs to the complex I subunit 6 family
K7H19_00495	COG0713	ATP synthesis coupled electron transport
K7H19_00500	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K7H19_00505	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K7H19_00510	COG1007	ATP synthesis coupled electron transport
K7H19_00515	COG0018	arginyl-trna synthetase
K7H19_00520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7H19_00525	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K7H19_00540	COG2070	2-Nitropropane dioxygenase
K7H19_00560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K7H19_00580	COG0513	Belongs to the DEAD box helicase family
K7H19_00585	COG0303	'Molybdopterin
K7H19_00605	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K7H19_00610	COG0442	prolyl-tRNA aminoacylation
K7H19_00615	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
K7H19_00625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K7H19_00640	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K7H19_00645	COG0758	DNA mediated transformation
K7H19_00645	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K7H19_00650	COG3546	catalase activity
K7H19_00655	COG0583	DNA-binding transcription factor activity
K7H19_00675	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7H19_00680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K7H19_00685	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K7H19_00690	COG0717	Belongs to the dCTP deaminase family
K7H19_00705	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_00710	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K7H19_00735	COG0515	serine threonine protein kinase
K7H19_00735	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K7H19_00745	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K7H19_00760	COG0704	Plays a role in the regulation of phosphate uptake
K7H19_00765	COG4191	Histidine kinase
K7H19_00770	COG0745	RESPONSE REGULATOR receiver
K7H19_00775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7H19_00785	COG1187	pseudouridine synthase activity
K7H19_00805	COG2414	aldehyde ferredoxin oxidoreductase
K7H19_00830	COG1902	pentaerythritol trinitrate reductase activity
K7H19_00850	COG0495	leucyl-tRNA aminoacylation
K7H19_00855	COG0539	negative regulation of cytoplasmic translation
K7H19_00865	COG0802	atpase or kinase
K7H19_00880	COG4242	Belongs to the peptidase S51 family
K7H19_00885	COG1309	transcriptional regulator
K7H19_00900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K7H19_00905	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K7H19_00910	COG1968	undecaprenyl-diphosphatase activity
K7H19_00915	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K7H19_00920	COG0484	heat shock protein binding
K7H19_00925	COG1278	Cold shock
K7H19_00935	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K7H19_00970	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7H19_00980	COG0583	DNA-binding transcription factor activity
K7H19_00985	COG0631	protein serine/threonine phosphatase activity
K7H19_00990	COG0105	UTP biosynthetic process
K7H19_01000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K7H19_01015	COG0477	Major facilitator Superfamily
K7H19_01030	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K7H19_01040	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K7H19_01045	COG2272	Belongs to the type-B carboxylesterase lipase family
K7H19_01050	COG0243	molybdopterin cofactor binding
K7H19_01060	COG3177	Filamentation induced by cAMP protein fic
K7H19_01070	COG0697	spore germination
K7H19_01085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
K7H19_01095	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K7H19_01100	COG0222	ribosome binding
K7H19_01105	COG4591	ABC-type transport system involved in lipoprotein release permease component
K7H19_01110	COG3584	3D domain protein
K7H19_01110	COG3583	domain protein
K7H19_01120	COG1461	Dihydroxyacetone kinase
K7H19_01130	COG0686	Belongs to the AlaDH PNT family
K7H19_01135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K7H19_01145	COG1187	pseudouridine synthase activity
K7H19_01150	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K7H19_01160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
K7H19_01165	COG2226	methyltransferase
K7H19_01190	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K7H19_01195	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K7H19_01200	COG0022	dehydrogenase e1 component
K7H19_01205	COG1598	PFAM Uncharacterised protein family UPF0150
K7H19_01220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K7H19_01255	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K7H19_01260	COG0321	lipoyl(octanoyl) transferase activity
K7H19_01265	COG0300	oxidoreductase activity
K7H19_01270	COG0359	binds to the 23S rRNA
K7H19_01275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K7H19_01280	COG0629	single-stranded DNA binding
K7H19_01295	COG0081	regulation of translation
K7H19_01305	COG0250	Participates in transcription elongation, termination and antitermination
K7H19_01310	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K7H19_01315	COG0267	Belongs to the bacterial ribosomal protein bL33 family
K7H19_01320	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K7H19_01345	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K7H19_01360	COG0735	belongs to the Fur family
K7H19_01365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K7H19_01375	COG0482	sulfurtransferase activity
K7H19_01380	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K7H19_01385	COG0573	inorganic phosphate transmembrane transporter activity
K7H19_01390	COG0581	inorganic phosphate transmembrane transporter activity
K7H19_01395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K7H19_01405	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K7H19_01415	COG0791	NLP P60 protein
K7H19_01415	COG1388	LysM domain
K7H19_01420	COG0778	Nitroreductase
K7H19_01430	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K7H19_01435	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K7H19_01440	COG0459	protein refolding
K7H19_01445	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K7H19_01455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7H19_01465	COG0166	Belongs to the GPI family
K7H19_01470	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K7H19_01480	COG0505	Belongs to the CarA family
K7H19_01495	COG0165	Argininosuccinate lyase
K7H19_01500	COG0137	argininosuccinate synthase activity
K7H19_01510	COG1404	Belongs to the peptidase S8 family
K7H19_01520	COG0508	dehydrogenase complex catalyzes the overall conversion of
K7H19_01530	COG1024	Enoyl-CoA hydratase
K7H19_01535	COG0632	four-way junction helicase activity
K7H19_01540	COG1011	Hydrolase
K7H19_01550	COG1611	Belongs to the LOG family
K7H19_01560	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K7H19_01565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7H19_01575	COG1940	carbohydrate kinase activity
K7H19_01595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K7H19_01600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K7H19_01605	COG0343	queuine tRNA-ribosyltransferase activity
K7H19_01620	COG1612	heme a metabolic process
K7H19_01620	COG0109	protoheme IX farnesyltransferase activity
K7H19_01625	COG2010	Cytochrome c
K7H19_01625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7H19_01630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K7H19_01630	COG1845	cytochrome c oxidase, subunit III
K7H19_01675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K7H19_01680	COG1660	Displays ATPase and GTPase activities
K7H19_01685	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K7H19_01700	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K7H19_01705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K7H19_01720	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K7H19_01725	COG1335	isochorismatase
K7H19_01730	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K7H19_01740	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K7H19_01750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K7H19_01755	COG1993	acr, cog1993
K7H19_01760	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K7H19_01765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K7H19_01790	COG0521	Mo-molybdopterin cofactor biosynthetic process
K7H19_01795	COG0436	Aminotransferase
K7H19_01800	COG0285	dihydrofolate synthase activity
K7H19_01810	COG0181	hydroxymethylbilane synthase activity
K7H19_01820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K7H19_01825	COG1950	PFAM Membrane protein of
K7H19_01830	COG0517	IMP dehydrogenase activity
K7H19_01830	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K7H19_01855	COG0033	Phosphoglucomutase
K7H19_01870	COG1653	transport
K7H19_01880	COG1278	Cold shock
K7H19_01885	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
K7H19_01890	COG1496	oxidoreductase activity
K7H19_01895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K7H19_01900	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K7H19_01910	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K7H19_01915	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K7H19_01920	COG0406	alpha-ribazole phosphatase activity
K7H19_01940	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_01945	COG0492	ferredoxin-NADP+ reductase activity
K7H19_01955	COG0792	nuclease activity
K7H19_01960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K7H19_01980	COG0395	ABC-type sugar transport system, permease component
K7H19_02010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K7H19_02015	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K7H19_02020	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7H19_02025	COG0805	protein transport
K7H19_02030	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K7H19_02030	COG1605	Chorismate mutase
K7H19_02085	COG1063	alcohol dehydrogenase
K7H19_02115	COG2255	four-way junction helicase activity
K7H19_02120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K7H19_02125	COG0564	pseudouridine synthase activity
K7H19_02140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K7H19_02145	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K7H19_02150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K7H19_02155	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K7H19_02165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K7H19_02170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K7H19_02175	COG0333	Belongs to the bacterial ribosomal protein bL32 family
K7H19_02210	COG0778	Nitroreductase
K7H19_02225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7H19_02230	COG0131	Imidazoleglycerol-phosphate dehydratase
K7H19_02235	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K7H19_02240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K7H19_02245	COG0516	GMP reductase activity
K7H19_02245	COG0517	IMP dehydrogenase activity
K7H19_02260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K7H19_02275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7H19_02285	COG2890	protein-(glutamine-N5) methyltransferase activity
K7H19_02295	COG0706	membrane insertase activity
K7H19_02300	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K7H19_02305	COG0594	ribonuclease P activity
K7H19_02310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
K7H19_02320	COG1022	Amp-dependent synthetase and ligase
K7H19_02345	COG1121	(ABC) transporter
K7H19_02350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K7H19_02355	COG1959	2 iron, 2 sulfur cluster binding
K7H19_02360	COG1104	cysteine desulfurase activity
K7H19_02365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K7H19_02370	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K7H19_02385	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_02410	COG0492	ferredoxin-NADP+ reductase activity
K7H19_02415	COG3321	synthase
K7H19_02415	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_02415	COG0604	alcohol dehydrogenase
K7H19_02425	COG0747	negative chemotaxis
K7H19_02430	COG0601	transmembrane transport
K7H19_02435	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7H19_02450	COG0517	IMP dehydrogenase activity
K7H19_02455	COG0123	including yeast histone deacetylase and acetoin utilization protein
K7H19_02460	COG2104	thiamine diphosphate biosynthetic process
K7H19_02465	COG0037	tRNA processing
K7H19_02490	COG0366	Alpha amylase catalytic
K7H19_02495	COG2226	methyltransferase
K7H19_02500	COG2226	methyltransferase
K7H19_02510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K7H19_02520	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K7H19_02525	COG3744	PilT protein domain protein
K7H19_02535	COG0460	homoserine dehydrogenase
K7H19_02545	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K7H19_02585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K7H19_02605	COG3742	Toxic component of a toxin-antitoxin (TA) module. An RNase
K7H19_02615	COG0247	lactate metabolic process
K7H19_02620	COG0277	FAD linked oxidase domain protein
K7H19_02625	COG0277	FAD linked oxidase domain protein
K7H19_02630	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K7H19_02635	COG1414	Transcriptional regulator
K7H19_02640	COG0789	Transcriptional regulator
K7H19_02650	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7H19_02655	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K7H19_02690	COG0861	Integral membrane protein TerC family
K7H19_02695	COG2151	metal-sulfur cluster biosynthetic enzyme
K7H19_02700	COG0281	malic enzyme
K7H19_02715	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K7H19_02720	COG0509	glycine decarboxylation via glycine cleavage system
K7H19_02725	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7H19_02730	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K7H19_02735	COG0196	riboflavin kinase activity
K7H19_02765	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K7H19_02770	COG2813	Specifically methylates the guanine in position
K7H19_02775	COG0527	aspartate kinase activity
K7H19_02805	COG4956	integral membrane protein (PIN domain superfamily)
K7H19_02810	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K7H19_02815	COG0542	response to heat
K7H19_02820	COG0423	glycine-tRNA ligase activity
K7H19_02830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K7H19_02850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K7H19_02850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K7H19_02860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K7H19_02870	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K7H19_02880	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K7H19_02885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K7H19_02890	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K7H19_02895	COG0114	fumarate hydratase activity
K7H19_02900	COG0183	Belongs to the thiolase family
K7H19_02915	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K7H19_02920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K7H19_02935	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K7H19_02940	COG1254	Belongs to the acylphosphatase family
K7H19_02950	COG1063	alcohol dehydrogenase
K7H19_02955	COG2133	pyrroloquinoline quinone binding
K7H19_02965	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K7H19_02970	COG0154	amidase activity
K7H19_02995	COG0572	uridine kinase
K7H19_03000	COG3842	ATPase activity
K7H19_03015	COG4475	Protein of unknown function (DUF436)
K7H19_03070	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K7H19_03075	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K7H19_03080	COG0803	Belongs to the bacterial solute-binding protein 9 family
K7H19_03095	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K7H19_03100	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K7H19_03105	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K7H19_03110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K7H19_03120	COG0318	PFAM AMP-dependent synthetase and ligase
K7H19_03130	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K7H19_03135	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K7H19_03140	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K7H19_03145	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K7H19_03155	COG3870	Protein conserved in bacteria
K7H19_03160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K7H19_03180	COG0544	peptidyl-prolyl cis-trans isomerase activity
K7H19_03185	COG0740	serine-type endopeptidase activity
K7H19_03190	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K7H19_03195	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K7H19_03200	COG1410	methionine synthase
K7H19_03200	COG0646	methionine synthase
K7H19_03210	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K7H19_03235	COG1692	metallophosphoesterase
K7H19_03240	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K7H19_03245	COG1970	mechanosensitive ion channel activity
K7H19_03265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K7H19_03275	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K7H19_03280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K7H19_03335	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K7H19_03370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7H19_03390	COG0489	protein tyrosine kinase activity
K7H19_03400	COG2264	protein methyltransferase activity
K7H19_03405	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K7H19_03440	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K7H19_03440	COG0574	Belongs to the PEP-utilizing enzyme family
K7H19_03450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K7H19_03455	COG2046	Belongs to the sulfate adenylyltransferase family
K7H19_03465	COG0730	response to heat
K7H19_03470	COG0175	sulfate reduction
K7H19_03475	COG1648	precorrin-2 dehydrogenase activity
K7H19_03475	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K7H19_03480	COG1587	Uroporphyrinogen-III synthase
K7H19_03485	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K7H19_03495	COG0352	thiamine-phosphate diphosphorylase activity
K7H19_03500	COG2104	thiamine diphosphate biosynthetic process
K7H19_03505	COG2022	thiamine diphosphate biosynthetic process
K7H19_03510	COG2022	thiamine diphosphate biosynthetic process
K7H19_03510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7H19_03515	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K7H19_03520	COG0477	Major facilitator Superfamily
K7H19_03525	COG0351	phosphomethylpyrimidine kinase
K7H19_03555	COG1175	transmembrane transport
K7H19_03565	COG1940	carbohydrate kinase activity
K7H19_03570	COG0183	Belongs to the thiolase family
K7H19_03585	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_03605	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7H19_03605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K7H19_03615	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K7H19_03625	COG0195	Participates in both transcription termination and antitermination
K7H19_03630	COG0779	Required for maturation of 30S ribosomal subunits
K7H19_03640	COG0739	heme binding
K7H19_03645	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K7H19_03650	COG0640	Transcriptional regulator
K7H19_03655	COG2217	Heavy metal translocating P-type atpase
K7H19_03660	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K7H19_03665	COG0017	Asparaginyl-tRNA synthetase
K7H19_03670	COG0561	phosphatase activity
K7H19_03675	COG0384	phenazine biosynthesis protein PhzF
K7H19_03685	COG0124	histidyl-tRNA synthetase
K7H19_03695	COG3842	ATPase activity
K7H19_03710	COG1573	uracil-dna glycosylase
K7H19_03730	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K7H19_03735	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7H19_03735	COG0519	Catalyzes the synthesis of GMP from XMP
K7H19_03745	COG1316	TRANSCRIPTIONal
K7H19_03755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K7H19_03800	COG0295	cytidine deaminase activity
K7H19_03810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7H19_03820	COG1760	l-serine dehydratase
K7H19_03830	COG0481	GTPase activity
K7H19_03840	COG0463	Glycosyl transferase, family 2
K7H19_03855	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7H19_03870	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_03895	COG0405	Gamma-glutamyltransferase
K7H19_03900	COG1073	alpha beta
K7H19_03915	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K7H19_03920	COG2873	o-acetylhomoserine
K7H19_03935	COG1063	alcohol dehydrogenase
K7H19_03945	COG3191	aminopeptidase activity
K7H19_03950	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
K7H19_03960	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K7H19_03965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K7H19_03970	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K7H19_04015	COG0167	dihydroorotate dehydrogenase activity
K7H19_04025	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K7H19_04030	COG0540	Belongs to the ATCase OTCase family
K7H19_04035	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K7H19_04045	COG0730	response to heat
K7H19_04050	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K7H19_04060	COG1960	acyl-CoA dehydrogenase activity
K7H19_04065	COG0456	acetyltransferase
K7H19_04075	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K7H19_04080	COG0009	L-threonylcarbamoyladenylate synthase
K7H19_04085	COG1459	type II secretion system
K7H19_04100	COG0277	FAD linked oxidase domain protein
K7H19_04110	COG0287	Prephenate dehydrogenase
K7H19_04115	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K7H19_04120	COG2514	catechol 2,3-dioxygenase activity
K7H19_04125	COG2353	YceI-like domain
K7H19_04130	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K7H19_04135	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K7H19_04150	COG1609	Transcriptional regulator
K7H19_04155	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K7H19_04160	COG0179	Fumarylacetoacetate (FAA) hydrolase
K7H19_04170	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K7H19_04175	COG0151	Belongs to the GarS family
K7H19_04180	COG5002	protein histidine kinase activity
K7H19_04180	COG2176	DNA-directed DNA polymerase activity
K7H19_04210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K7H19_04225	COG0217	transcriptional regulatory protein
K7H19_04230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K7H19_04230	COG4651	solute:proton antiporter activity
K7H19_04235	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K7H19_04240	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K7H19_04245	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K7H19_04250	COG1674	ftsk spoiiie
K7H19_04265	COG0517	IMP dehydrogenase activity
K7H19_04280	COG0617	tRNA 3'-terminal CCA addition
K7H19_04280	COG3620	sequence-specific DNA binding
K7H19_04280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K7H19_04290	COG1994	Peptidase M50
K7H19_04295	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K7H19_04305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7H19_04320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K7H19_04330	COG2719	SpoVR family
K7H19_04335	COG2718	Belongs to the UPF0229 family
K7H19_04340	COG2766	serine protein kinase
K7H19_04365	COG2137	regulation of response to DNA damage stimulus
K7H19_04375	COG2359	stage V sporulation protein S
K7H19_04380	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K7H19_04385	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K7H19_04395	COG0463	Glycosyl transferase, family 2
K7H19_04400	COG0750	zinc metalloprotease
K7H19_04405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K7H19_04410	COG4589	Belongs to the CDS family
K7H19_04415	COG0233	cytoplasmic translational termination
K7H19_04420	COG0528	UMP kinase activity
K7H19_04425	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K7H19_04430	COG0052	Belongs to the universal ribosomal protein uS2 family
K7H19_04440	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K7H19_04445	COG0494	nUDIX hydrolase
K7H19_04485	COG0402	S-adenosylhomocysteine deaminase activity
K7H19_04495	COG4948	Mandelate Racemase Muconate Lactonizing
K7H19_04500	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K7H19_04505	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K7H19_04510	COG1811	Na channel or pump
K7H19_04515	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7H19_04515	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
K7H19_04530	COG1215	transferase activity, transferring glycosyl groups
K7H19_04545	COG1215	transferase activity, transferring glycosyl groups
K7H19_04555	COG0438	transferase activity, transferring glycosyl groups
K7H19_04560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K7H19_04570	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7H19_04570	COG1024	Enoyl-CoA hydratase
K7H19_04575	COG0183	Belongs to the thiolase family
K7H19_04580	COG1960	acyl-CoA dehydrogenase activity
K7H19_04585	COG0215	cysteine-tRNA ligase activity
K7H19_04590	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K7H19_04600	COG2738	Putative neutral zinc metallopeptidase
K7H19_04615	COG1196	nuclear chromosome segregation
K7H19_04630	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K7H19_04635	COG3153	acetyltransferase
K7H19_04635	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7H19_04640	COG1268	BioY protein
K7H19_04650	COG0126	phosphoglycerate kinase activity
K7H19_04655	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K7H19_04660	COG0824	Thioesterase
K7H19_04670	COG0557	exoribonuclease II activity
K7H19_04680	COG1355	regulation of microtubule-based process
K7H19_04685	COG1353	crispr-associated protein
K7H19_04685	COG0617	tRNA 3'-terminal CCA addition
K7H19_04690	COG0237	dephospho-CoA kinase activity
K7H19_04705	COG0742	ribosomal rna small subunit methyltransferase
K7H19_04710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K7H19_04715	COG0138	bifunctional purine biosynthesis protein purh
K7H19_04720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K7H19_04735	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K7H19_04790	COG0149	triose-phosphate isomerase activity
K7H19_04795	COG3239	Fatty acid desaturase
K7H19_04800	COG1490	D-aminoacyl-tRNA deacylase activity
K7H19_04805	COG1307	EDD domain protein, DegV family
K7H19_04810	COG1307	EDD domain protein, DegV family
K7H19_04815	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K7H19_04820	COG1510	regulation of RNA biosynthetic process
K7H19_04830	COG3769	mannosylglycerate metabolic process
K7H19_04840	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K7H19_04850	COG1012	belongs to the aldehyde dehydrogenase family
K7H19_04855	COG2368	4-hydroxyphenylacetate
K7H19_04860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K7H19_04880	COG2050	protein possibly involved in aromatic compounds catabolism
K7H19_04885	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
K7H19_04895	COG2030	dehydratase
K7H19_04895	COG1012	belongs to the aldehyde dehydrogenase family
K7H19_04915	COG3396	Phenylacetate-CoA oxygenase
K7H19_04925	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K7H19_04935	COG0395	ABC-type sugar transport system, permease component
K7H19_04955	COG1980	fructose-bisphosphate aldolase activity
K7H19_04960	COG1733	regulation of RNA biosynthetic process
K7H19_04970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K7H19_04975	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K7H19_04985	COG1331	Highly conserved protein containing a thioredoxin domain
K7H19_04990	COG0183	Belongs to the thiolase family
K7H19_04995	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K7H19_05035	COG1012	belongs to the aldehyde dehydrogenase family
K7H19_05065	COG0745	RESPONSE REGULATOR receiver
K7H19_05070	COG2205	protein histidine kinase activity
K7H19_05085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K7H19_05090	COG1136	(ABC) transporter
K7H19_05095	COG1136	(ABC) transporter
K7H19_05095	COG0577	efflux transmembrane transporter activity
K7H19_05165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K7H19_05200	COG0582	viral genome integration into host DNA
K7H19_05210	COG2897	thiosulfate sulfurtransferase activity
K7H19_05215	COG1760	l-serine dehydratase
K7H19_05220	COG2197	response regulator
K7H19_05225	COG0335	large ribosomal subunit rRNA binding
K7H19_05230	COG0336	Belongs to the RNA methyltransferase TrmD family
K7H19_05235	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K7H19_05240	COG1837	Belongs to the UPF0109 family
K7H19_05245	COG0228	four-way junction DNA binding
K7H19_05260	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7H19_05265	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7H19_05265	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7H19_05270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K7H19_05280	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K7H19_05290	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K7H19_05295	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K7H19_05300	COG1702	phosphate starvation-inducible protein PhoH
K7H19_05310	COG4864	UPF0365 protein
K7H19_05320	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K7H19_05340	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7H19_05340	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K7H19_05350	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K7H19_05360	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K7H19_05365	COG1397	ADP-ribosylglycohydrolase
K7H19_05370	COG2239	Acts as a magnesium transporter
K7H19_05380	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K7H19_05380	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K7H19_05390	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7H19_05390	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K7H19_05395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K7H19_05400	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K7H19_05405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K7H19_05410	COG0006	proline dipeptidase activity
K7H19_05420	COG0739	heme binding
K7H19_05430	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K7H19_05435	COG0254	rRNA binding
K7H19_05450	COG2001	Belongs to the MraZ family
K7H19_05455	COG0275	rRNA processing
K7H19_05465	COG0768	penicillin binding
K7H19_05470	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K7H19_05480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7H19_05485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K7H19_05490	COG0772	Belongs to the SEDS family
K7H19_05495	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K7H19_05500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K7H19_05505	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K7H19_05525	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
K7H19_05535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
K7H19_05545	COG0159	tryptophan synthase activity
K7H19_05550	COG0133	tryptophan synthase activity
K7H19_05555	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
K7H19_05560	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K7H19_05565	COG1744	ABC transporter substrate-binding protein PnrA-like
K7H19_05570	COG3845	ABC transporter
K7H19_05620	COG0438	transferase activity, transferring glycosyl groups
K7H19_05625	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K7H19_05635	COG0039	L-malate dehydrogenase activity
K7H19_05640	COG2819	hydrolase of the alpha beta superfamily
K7H19_05645	COG0861	Integral membrane protein TerC family
K7H19_05655	COG0247	lactate metabolic process
K7H19_05655	COG2181	nitrate reductase activity
K7H19_05665	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K7H19_05670	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K7H19_05675	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K7H19_05685	COG0439	Biotin carboxylase
K7H19_05690	COG0511	ligase activity, forming carbon-carbon bonds
K7H19_05695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K7H19_05715	COG0010	Belongs to the arginase family
K7H19_05730	COG1100	Small GTP-binding protein
K7H19_05740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K7H19_05745	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K7H19_05755	COG2814	Major facilitator Superfamily
K7H19_05760	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K7H19_05765	COG1185	polyribonucleotide nucleotidyltransferase activity
K7H19_05770	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K7H19_05780	COG0745	RESPONSE REGULATOR receiver
K7H19_05785	COG5002	protein histidine kinase activity
K7H19_05790	COG1960	acyl-CoA dehydrogenase activity
K7H19_05795	COG2086	electron transfer activity
K7H19_05800	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K7H19_05810	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7H19_05815	COG1573	uracil-dna glycosylase
K7H19_05820	COG1796	DNA polymerase
K7H19_05820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K7H19_05830	COG2309	aminopeptidase activity
K7H19_05845	COG2873	o-acetylhomoserine
K7H19_05850	COG2358	TRAP transporter, solute receptor (TAXI family
K7H19_05860	COG1126	abc transporter atp-binding protein
K7H19_05870	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7H19_05875	COG3311	Transcriptional regulator
K7H19_05885	COG0134	indole-3-glycerol-phosphate synthase activity
K7H19_05890	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K7H19_05900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K7H19_05915	COG0765	amino acid transport
K7H19_05920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K7H19_05930	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K7H19_05935	COG0569	domain protein
K7H19_05940	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7H19_05945	COG1426	Protein conserved in bacteria
K7H19_05950	COG2313	pseudouridylate synthase activity
K7H19_05960	COG3001	Fructosamine kinase
K7H19_05965	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7H19_05975	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
K7H19_06000	COG0012	GTP binding
K7H19_06005	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K7H19_06015	COG0424	maF-like protein
K7H19_06030	COG0768	penicillin binding
K7H19_06040	COG2322	membrane
K7H19_06055	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K7H19_06060	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K7H19_06070	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K7H19_06090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K7H19_06100	COG1131	(ABC) transporter
K7H19_06115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7H19_06130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K7H19_06135	COG0440	acetolactate synthase activity
K7H19_06140	COG0028	Belongs to the TPP enzyme family
K7H19_06145	COG0492	ferredoxin-NADP+ reductase activity
K7H19_06150	COG4970	Tfp pilus assembly protein FimT
K7H19_06175	COG2165	general secretion pathway protein
K7H19_06205	COG0180	Tryptophanyl-tRNA synthetase
K7H19_06210	COG0544	peptidyl-prolyl cis-trans isomerase activity
K7H19_06215	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K7H19_06220	COG0066	3-isopropylmalate dehydratase activity
K7H19_06225	COG0473	3-isopropylmalate dehydrogenase activity
K7H19_06240	COG0300	oxidoreductase activity
K7H19_06245	COG0129	dihydroxy-acid dehydratase activity
K7H19_06255	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K7H19_06260	COG1177	transmembrane transport
K7H19_06265	COG1176	ABC-type spermidine putrescine transport system, permease component I
K7H19_06270	COG3842	ATPase activity
K7H19_06275	COG0772	Belongs to the SEDS family
K7H19_06280	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K7H19_06285	COG2894	cell division
K7H19_06290	COG1733	regulation of RNA biosynthetic process
K7H19_06300	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7H19_06300	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
K7H19_06310	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7H19_06315	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7H19_06320	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7H19_06325	COG0653	protein targeting
K7H19_06330	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K7H19_06350	COG0393	Putative heavy-metal-binding
K7H19_06355	COG1111	helicase
K7H19_06355	COG1205	dead DEAH box helicase
K7H19_06370	COG0358	DNA primase activity
K7H19_06380	COG1250	3-hydroxyacyl-CoA dehydrogenase
K7H19_06385	COG0697	spore germination
K7H19_06390	COG0612	Peptidase, M16
K7H19_06395	COG0612	Peptidase, M16
K7H19_06400	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K7H19_06425	COG1394	ATPase activity, coupled to movement of substances
K7H19_06430	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
K7H19_06435	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
K7H19_06440	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
K7H19_06445	COG1527	subunit (C
K7H19_06450	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
K7H19_06460	COG1269	ATP hydrolysis coupled proton transport
K7H19_06485	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K7H19_06495	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K7H19_06510	COG0419	ATPase involved in DNA repair
K7H19_06515	COG0420	3'-5' exonuclease activity
K7H19_06535	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K7H19_06540	COG2884	Cell division ATP-binding protein ftsE
K7H19_06545	COG0793	Belongs to the peptidase S41A family
K7H19_06555	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7H19_06555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K7H19_06560	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K7H19_06565	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K7H19_06575	COG1079	Belongs to the binding-protein-dependent transport system permease family
K7H19_06580	COG4603	Belongs to the binding-protein-dependent transport system permease family
K7H19_06585	COG1129	ABC transporter
K7H19_06590	COG0746	molybdenum cofactor guanylyltransferase activity
K7H19_06605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7H19_06625	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K7H19_06630	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K7H19_06635	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K7H19_06645	COG0517	IMP dehydrogenase activity
K7H19_06645	COG1994	Peptidase M50
K7H19_06670	COG0788	formyltetrahydrofolate deformylase activity
K7H19_06675	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K7H19_06680	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K7H19_06685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K7H19_06705	COG0737	Belongs to the 5'-nucleotidase family
K7H19_06710	COG0174	glutamine synthetase
K7H19_06720	COG0559	Belongs to the binding-protein-dependent transport system permease family
K7H19_06740	COG0747	negative chemotaxis
K7H19_06745	COG0601	transmembrane transport
K7H19_06750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7H19_06760	COG0285	dihydrofolate synthase activity
K7H19_06765	COG1132	(ABC) transporter
K7H19_06770	COG1132	(ABC) transporter
K7H19_06775	COG0372	Belongs to the citrate synthase family
K7H19_06780	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K7H19_06785	COG1482	cell wall glycoprotein biosynthetic process
K7H19_06795	COG1515	deoxyribonuclease V activity
K7H19_06805	COG0776	regulation of translation
K7H19_06820	COG2197	response regulator
K7H19_06825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K7H19_06830	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K7H19_06835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K7H19_06840	COG1324	tolerance protein
K7H19_06855	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7H19_06875	COG2205	protein histidine kinase activity
K7H19_06885	COG0247	lactate metabolic process
K7H19_06890	COG1139	Iron-sulfur cluster binding protein
K7H19_06895	COG1556	Lactate utilization protein
K7H19_06905	COG1752	Esterase of the alpha-beta hydrolase superfamily
K7H19_06910	COG2815	serine threonine protein kinase
K7H19_06910	COG0515	serine threonine protein kinase
K7H19_06920	COG0860	N-Acetylmuramoyl-L-alanine amidase
K7H19_06930	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K7H19_06960	COG0473	3-isopropylmalate dehydrogenase activity
K7H19_06985	COG1450	Type ii and iii secretion system protein
K7H19_06990	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K7H19_06995	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K7H19_07000	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K7H19_07005	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K7H19_07005	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
K7H19_07010	COG0736	holo-[acyl-carrier-protein] synthase activity
K7H19_07025	COG1160	GTP binding
K7H19_07030	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K7H19_07035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
K7H19_07035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K7H19_07040	COG0083	homoserine kinase activity
K7H19_07055	COG0268	Binds directly to 16S ribosomal RNA
K7H19_07065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K7H19_07070	COG0723	plastoquinol--plastocyanin reductase activity
K7H19_07080	COG3088	subunit of a heme lyase
K7H19_07080	COG4235	cytochrome complex assembly
K7H19_07085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7H19_07090	COG1138	Cytochrome C-type biogenesis protein
K7H19_07095	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
K7H19_07100	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K7H19_07105	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K7H19_07110	COG4133	protoheme IX ABC transporter activity
K7H19_07115	COG0785	Cytochrome C biogenesis protein
K7H19_07120	COG3258	Cytochrome c
K7H19_07130	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7H19_07145	COG3258	Cytochrome c
K7H19_07150	COG2010	Cytochrome c
K7H19_07155	COG0737	Belongs to the 5'-nucleotidase family
K7H19_07160	COG2010	Cytochrome c
K7H19_07165	COG3258	Cytochrome c
K7H19_07185	COG2010	Cytochrome c
K7H19_07190	COG3842	ATPase activity
K7H19_07220	COG0318	PFAM AMP-dependent synthetase and ligase
K7H19_07225	COG3360	Dodecin
K7H19_07240	COG1024	Enoyl-CoA hydratase
K7H19_07245	COG0813	purine-nucleoside phosphorylase activity
K7H19_07250	COG1136	(ABC) transporter
K7H19_07255	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K7H19_07260	COG2045	Belongs to the ComB family
K7H19_07270	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K7H19_07280	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K7H19_07290	COG0107	imidazoleglycerol-phosphate synthase activity
K7H19_07295	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K7H19_07295	COG0140	phosphoribosyl-ATP diphosphatase activity
K7H19_07300	COG1494	fructose-1,6-bisphosphatase
K7H19_07305	COG0686	Belongs to the AlaDH PNT family
K7H19_07310	COG0427	acetyl-CoA hydrolase
K7H19_07315	COG0084	hydrolase, TatD family'
K7H19_07320	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K7H19_07330	COG0017	Asparaginyl-tRNA synthetase
K7H19_07335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K7H19_07350	COG2009	succinate dehydrogenase
K7H19_07355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K7H19_07385	COG0318	PFAM AMP-dependent synthetase and ligase
K7H19_07390	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K7H19_07395	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K7H19_07400	COG0504	CTP synthase activity
K7H19_07415	COG0070	glutamate synthase
K7H19_07415	COG0069	glutamate synthase activity
K7H19_07415	COG0067	glutamate synthase
K7H19_07420	COG0840	transmembrane signaling receptor activity
K7H19_07425	COG0305	Participates in initiation and elongation during chromosome replication
K7H19_07435	COG0475	glutathione-regulated potassium exporter activity
K7H19_07440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K7H19_07440	COG0617	tRNA 3'-terminal CCA addition
K7H19_07440	COG0517	IMP dehydrogenase activity
K7H19_07455	COG0475	glutathione-regulated potassium exporter activity
K7H19_07460	COG0490	domain, Protein
K7H19_07480	COG3118	belongs to the thioredoxin family
K7H19_07510	COG0542	response to heat
K7H19_07515	COG0789	Transcriptional regulator
K7H19_07520	COG0484	heat shock protein binding
K7H19_07525	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K7H19_07530	COG0443	Heat shock 70 kDa protein
K7H19_07535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K7H19_07540	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K7H19_07545	COG0616	signal peptide processing
K7H19_07560	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
K7H19_07565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K7H19_07570	COG0714	Associated with various cellular activities
K7H19_07575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K7H19_07575	COG0574	Belongs to the PEP-utilizing enzyme family
K7H19_07580	COG1272	protein, Hemolysin III
K7H19_07590	COG3850	Histidine kinase
K7H19_07590	COG5002	protein histidine kinase activity
K7H19_07605	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K7H19_07620	COG1011	Hydrolase
K7H19_07640	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K7H19_07650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K7H19_07660	COG0047	phosphoribosylformylglycinamidine synthase activity
K7H19_07670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K7H19_07675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K7H19_07680	COG0116	Belongs to the methyltransferase superfamily
K7H19_07695	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K7H19_07700	COG0497	DNA recombination
K7H19_07710	COG0604	alcohol dehydrogenase
K7H19_07730	COG0585	pseudouridine synthase activity
K7H19_07745	COG0557	exoribonuclease II activity
K7H19_07750	COG0473	3-isopropylmalate dehydrogenase activity
K7H19_07775	COG4974	Belongs to the 'phage' integrase family
K7H19_07785	COG0590	tRNA wobble adenosine to inosine editing
K7H19_07785	COG0037	tRNA processing
K7H19_07810	COG2050	protein possibly involved in aromatic compounds catabolism
K7H19_07820	COG0322	excinuclease ABC activity
K7H19_07825	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K7H19_07830	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K7H19_07835	COG1854	S-ribosylhomocysteine lyase activity
K7H19_07840	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K7H19_07840	COG0519	Catalyzes the synthesis of GMP from XMP
K7H19_07845	COG4636	protein conserved in cyanobacteria
K7H19_07850	COG4274	PFAM GYD family protein
K7H19_07855	COG0346	lactoylglutathione lyase activity
K7H19_07860	COG0328	RNA-DNA hybrid ribonuclease activity
K7H19_07865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K7H19_07870	COG2095	MarC family integral membrane protein
K7H19_07875	COG1438	arginine binding
K7H19_07880	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K7H19_07885	COG1758	RNA polymerase activity
K7H19_07890	COG0194	GDP metabolic process
K7H19_07900	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K7H19_07905	COG2385	sporulation resulting in formation of a cellular spore
K7H19_07910	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K7H19_07920	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
K7H19_07960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K7H19_07965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K7H19_07970	COG1012	belongs to the aldehyde dehydrogenase family
K7H19_07975	COG0506	proline dehydrogenase activity
K7H19_07990	COG0156	8-amino-7-oxononanoate synthase activity
K7H19_07995	COG0732	type I restriction modification DNA specificity domain
K7H19_07995	COG0827	DNA restriction-modification system
K7H19_08010	COG0187	DNA topoisomerase II activity
K7H19_08015	COG1181	Belongs to the D-alanine--D-alanine ligase family
K7H19_08020	COG0193	aminoacyl-tRNA hydrolase activity
K7H19_08025	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K7H19_08050	COG2815	serine threonine protein kinase
K7H19_08050	COG0515	serine threonine protein kinase
K7H19_08055	COG0631	protein serine/threonine phosphatase activity
K7H19_08065	COG2814	Major facilitator Superfamily
K7H19_08070	COG0113	porphobilinogen synthase activity
K7H19_08075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K7H19_08080	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K7H19_08105	COG4946	Tricorn protease homolog
K7H19_08105	COG1506	peptidase
K7H19_08105	COG0823	Involved in the tonB-independent uptake of proteins
K7H19_08110	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K7H19_08115	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K7H19_08135	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K7H19_08140	COG1011	Hydrolase
K7H19_08165	COG0537	adenosine 5'-monophosphoramidase activity
K7H19_08170	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K7H19_08175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K7H19_08180	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K7H19_08185	COG0071	Belongs to the small heat shock protein (HSP20) family
K7H19_08190	COG2897	thiosulfate sulfurtransferase activity
K7H19_08195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K7H19_08205	COG1764	response to oxidative stress
K7H19_08230	COG3842	ATPase activity
K7H19_08235	COG0101	tRNA pseudouridine synthase activity
K7H19_08240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K7H19_08245	COG0601	transmembrane transport
K7H19_08250	COG0747	negative chemotaxis
K7H19_08260	COG0006	proline dipeptidase activity
K7H19_08265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K7H19_08280	COG1166	arginine decarboxylase activity
K7H19_08285	COG3706	GGDEF domain
K7H19_08290	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K7H19_08295	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K7H19_08300	COG1611	Belongs to the LOG family
K7H19_08305	COG1193	negative regulation of DNA recombination
K7H19_08315	COG0366	Alpha amylase catalytic
K7H19_08355	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K7H19_08360	COG0142	geranyltranstransferase activity
K7H19_08370	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K7H19_08400	COG0203	ribosomal protein L17
K7H19_08405	COG0202	RNA polymerase activity
K7H19_08410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K7H19_08415	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K7H19_08420	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K7H19_08430	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
K7H19_08440	COG0563	adenylate kinase activity
K7H19_08445	COG0201	protein transport
K7H19_08470	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K7H19_08475	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K7H19_08480	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K7H19_08495	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K7H19_08500	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K7H19_08505	COG0255	Belongs to the universal ribosomal protein uL29 family
K7H19_08510	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K7H19_08515	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K7H19_08525	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
K7H19_08530	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K7H19_08535	COG0089	rRNA binding
K7H19_08540	COG0088	Forms part of the polypeptide exit tunnel
K7H19_08550	COG0051	transcription antitermination factor activity, RNA binding
K7H19_08565	COG0049	tRNA binding
K7H19_08580	COG0442	prolyl-tRNA aminoacylation
K7H19_08600	COG1115	amino acid carrier protein
K7H19_08620	COG1489	DNA binding
K7H19_08645	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
K7H19_08665	COG0432	Pfam Uncharacterised protein family UPF0047
K7H19_08670	COG3253	May function as heme-dependent peroxidase
K7H19_08675	COG0668	transmembrane transport
K7H19_08685	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K7H19_08690	COG2217	Heavy metal translocating P-type atpase
K7H19_08710	COG0745	RESPONSE REGULATOR receiver
K7H19_08715	COG2205	protein histidine kinase activity
K7H19_08735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K7H19_08740	COG2226	methyltransferase
K7H19_08770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K7H19_08775	COG0822	iron-sulfur transferase activity
K7H19_08795	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K7H19_08805	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K7H19_08810	COG0284	orotidine-5'-phosphate decarboxylase activity
K7H19_08825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K7H19_08835	COG0416	fatty acid biosynthetic process
K7H19_08840	COG3118	belongs to the thioredoxin family
K7H19_08845	COG1185	polyribonucleotide nucleotidyltransferase activity
K7H19_08850	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K7H19_08860	COG0438	transferase activity, transferring glycosyl groups
K7H19_08880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K7H19_08895	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K7H19_08930	COG0437	4 iron, 4 sulfur cluster binding
K7H19_08945	COG0825	malonyl-CoA metabolic process
K7H19_08950	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K7H19_08985	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K7H19_09010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K7H19_09015	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K7H19_09020	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K7H19_09025	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K7H19_09070	COG0315	cyclic pyranopterin monophosphate synthase activity
K7H19_09080	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K7H19_09095	COG1694	Mazg nucleotide pyrophosphohydrolase
K7H19_09100	COG1803	Methylglyoxal synthase
K7H19_09110	COG0301	tRNA thio-modification
K7H19_09115	COG0154	amidase activity
K7H19_09120	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K7H19_09145	COG2154	pterin-4-alpha-carbinolamine dehydratase
K7H19_09150	COG1607	acyl-coa hydrolase
K7H19_09160	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K7H19_09165	COG4149	molybdate abc transporter
K7H19_09170	COG1840	ABC-type Fe3 transport system, periplasmic component
K7H19_09185	COG0235	Class ii aldolase
K7H19_09190	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K7H19_09195	COG0085	RNA polymerase activity
K7H19_09205	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K7H19_09210	COG1077	Cell shape determining protein MreB Mrl
K7H19_09215	COG1418	mRNA catabolic process
K7H19_09215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K7H19_09220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K7H19_09225	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K7H19_09230	COG1546	Belongs to the CinA family
K7H19_09230	COG1058	Belongs to the CinA family
K7H19_09235	COG0354	folic acid binding
K7H19_09250	COG4948	Mandelate Racemase Muconate Lactonizing
K7H19_09265	COG1175	transmembrane transport
K7H19_09275	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K7H19_09285	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K7H19_09295	COG0577	efflux transmembrane transporter activity
K7H19_09295	COG1136	(ABC) transporter
K7H19_09300	COG4181	ATPase activity
K7H19_09305	COG0446	pyridine nucleotide-disulphide oxidoreductase
K7H19_09320	COG0396	ATPase activity
K7H19_09325	COG0719	Fe-S assembly protein
K7H19_09330	COG0719	Fe-S assembly protein
K7H19_09335	COG2146	nitrite reductase [NAD(P)H] activity
K7H19_09345	COG0512	Glutamine amidotransferase of anthranilate synthase
K7H19_09350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K7H19_09390	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K7H19_09395	COG2226	methyltransferase
K7H19_09415	COG1079	Belongs to the binding-protein-dependent transport system permease family
K7H19_09430	COG1774	PSP1 C-terminal conserved region
K7H19_09435	COG0470	DNA polymerase III
K7H19_09455	COG0497	DNA recombination
K7H19_09510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K7H19_09525	COG0302	gtp cyclohydrolase
K7H19_09555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K7H19_09565	COG0395	ABC-type sugar transport system, permease component
K7H19_09580	COG1131	(ABC) transporter
K7H19_09600	COG0556	nucleotide-excision repair
K7H19_09605	COG0497	DNA recombination
K7H19_09615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K7H19_09625	COG0445	tRNA wobble uridine modification
K7H19_09645	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K7H19_09645	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K7H19_09650	COG1543	Belongs to the glycosyl hydrolase 57 family
K7H19_09655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K7H19_09660	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K7H19_09675	COG0189	ligase activity
K7H19_09690	COG0066	3-isopropylmalate dehydratase activity
K7H19_09695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K7H19_09710	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K7H19_09715	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K7H19_09720	COG1960	acyl-CoA dehydrogenase activity
K7H19_09725	COG0163	prenyltransferase activity
K7H19_09770	COG4555	ABC transporter
K7H19_09780	COG2096	Adenosyltransferase
K7H19_09800	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K7H19_09805	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K7H19_09815	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K7H19_09820	COG0723	plastoquinol--plastocyanin reductase activity
K7H19_09845	COG1653	transport
K7H19_09850	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K7H19_09855	COG1960	acyl-CoA dehydrogenase activity
K7H19_09865	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K7H19_09885	COG0393	Putative heavy-metal-binding
K7H19_09895	COG3956	TIGRFAM MazG family protein
K7H19_09900	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
K7H19_09915	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K7H19_09925	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K7H19_09930	COG1937	Protein conserved in bacteria
K7H19_09940	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
K7H19_09940	COG0674	pyruvate-flavodoxin oxidoreductase activity
K7H19_09945	COG1013	pyruvate-flavodoxin oxidoreductase activity
K7H19_09950	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K7H19_09970	COG0205	6-phosphofructokinase activity
K7H19_09975	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K7H19_09985	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K7H19_10000	COG2333	competence protein COMEC
K7H19_10000	COG0658	competence protein
K7H19_10005	COG1475	DNA binding
K7H19_10010	COG1192	Involved in chromosome partitioning
K7H19_10015	COG0357	Ribosomal RNA small subunit methyltransferase G
K7H19_10020	COG0445	tRNA wobble uridine modification
K7H19_10045	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
K7H19_10060	COG1337	RAMP superfamily
K7H19_10170	COG1110	DNA topoisomerase II activity
K7H19_10175	COG4565	transcriptional regulatory protein
K7H19_10185	COG3842	ATPase activity
K7H19_10235	COG0863	Belongs to the N(4) N(6)-methyltransferase family
K7H19_10260	COG1857	crispr-associated protein
K7H19_10280	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K7H19_10290	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K7H19_10330	COG1607	acyl-coa hydrolase
K7H19_10340	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K7H19_10385	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K7H19_10390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K7H19_10395	COG4558	Periplasmic binding protein
K7H19_10405	COG2329	Antibiotic biosynthesis monooxygenase
K7H19_10505	COG1942	4-Oxalocrotonate Tautomerase
K7H19_10525	COG2084	Dehydrogenase
K7H19_10600	COG0588	phosphoglycerate mutase activity
K7H19_10620	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_10625	COG0318	PFAM AMP-dependent synthetase and ligase
K7H19_10635	COG2030	dehydratase
K7H19_10635	COG1012	belongs to the aldehyde dehydrogenase family
K7H19_10640	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_10650	COG1960	acyl-CoA dehydrogenase activity
K7H19_10715	COG2211	Major facilitator Superfamily
K7H19_10745	COG1797	cobyrinic acid a,c-diamide synthase activity
K7H19_10750	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
K7H19_10760	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K7H19_10775	COG0588	phosphoglycerate mutase activity
K7H19_10780	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K7H19_10785	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K7H19_10830	COG1648	precorrin-2 dehydrogenase activity
K7H19_10830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K7H19_10835	COG0778	Nitroreductase
K7H19_10855	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K7H19_10860	COG1492	cobalamin metabolic process
K7H19_10865	COG1785	Belongs to the alkaline phosphatase family
K7H19_10895	COG1414	Transcriptional regulator
K7H19_10900	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K7H19_10910	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K7H19_10915	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_10930	COG1028	Short-chain dehydrogenase reductase Sdr
K7H19_10965	COG2723	6-phospho-beta-galactosidase activity
K7H19_10970	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K7H19_10990	COG1233	COG1233 Phytoene dehydrogenase and related
K7H19_10995	COG0702	epimerase
K7H19_11035	COG1562	ergosterol biosynthetic process
K7H19_11045	COG2124	cytochrome p450
K7H19_11080	COG1304	FMN binding
K7H19_11100	COG1085	galactose-1-phosphate uridylyltransferase
K7H19_11105	COG3345	alpha-galactosidase
K7H19_11130	COG4966	pilus assembly protein PilW
K7H19_11160	COG1475	DNA binding
K7H19_11165	COG1192	Involved in chromosome partitioning
K7H19_11175	COG0243	molybdopterin cofactor binding
K7H19_11240	COG2151	metal-sulfur cluster biosynthetic enzyme
K7H19_11250	COG2814	Major facilitator Superfamily
K7H19_11260	COG0584	glycerophosphoryl diester phosphodiesterase
K7H19_11270	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K7H19_11315	COG3335	DDE superfamily endonuclease
K7H19_11460	COG2002	toxin-antitoxin pair type II binding
K7H19_11480	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K7H19_11505	COG0300	oxidoreductase activity
K7H19_11510	COG0673	inositol 2-dehydrogenase activity
K7H19_11520	COG1070	Carbohydrate kinase
K7H19_11535	COG1129	ABC transporter
K7H19_11540	COG4214	carbohydrate transport
K7H19_11545	COG4213	ABC transporter substrate-binding protein
K7H19_11570	COG1192	Involved in chromosome partitioning
K7H19_11575	COG1475	DNA binding
K7H19_11630	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K7H19_11640	COG3639	organic phosphonate transmembrane transporter activity
K7H19_11660	COG3627	carbon phosphorus lyase activity
K7H19_11670	COG4778	phosphonate C-P lyase system protein PhnL
K7H19_11675	COG3454	Phosphonate metabolism
K7H19_11685	COG3842	ATPase activity
K7H19_11695	COG1692	metallophosphoesterase
K7H19_11710	COG1175	transmembrane transport
K7H19_11715	COG0395	ABC-type sugar transport system, permease component