locus-tag	class	description
Ththe16_0001	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
Ththe16_0002	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
Ththe16_0003	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
Ththe16_0004	ENOG4105CA9	Pyruvate kinase
Ththe16_0006	ENOG4108RW0	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)
Ththe16_0007	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
Ththe16_0009	ENOG41087YS	Phage shock protein A
Ththe16_0012	ENOG4105CVJ	phosphoglycerate mutase
Ththe16_0013	ENOG4105CXB	phosphoribosylaminoimidazole synthetase
Ththe16_0014	ENOG4105CHT	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)
Ththe16_0015	ENOG4105CZX	twitching motility protein
Ththe16_0016	ENOG4107QHF	type ii secretion system protein e
Ththe16_0017	ENOG4108WJV	had superfamily (subfamily IIIa) phosphatase
Ththe16_0018	ENOG4105DBW	Multi-copper polyphenol oxidoreductase laccase
Ththe16_0019	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
Ththe16_0021	ENOG4107T3P	ABC, transporter
Ththe16_0024	ENOG4107QIX	Phosphoglucomutase (EC 5.4.2.2
Ththe16_0026	ENOG4107RDB	Major Facilitator
Ththe16_0028	ENOG4105C2X	Arabinose 5-phosphate isomerase
Ththe16_0029	ENOG41082T9	Membrane
Ththe16_0030	ENOG4105C6T	cysteine synthase
Ththe16_0031	ENOG4108YZY	peptidylprolyl cis-trans isomerase
Ththe16_0032	ENOG4105D6W	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)
Ththe16_0034	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Ththe16_0035	ENOG4105CHM	Aminotransferase
Ththe16_0036	ENOG4108RIR	Molybdenum cofactor biosynthesis protein
Ththe16_0041	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
Ththe16_0042	ENOG4105WMR	Protein CrcB homolog
Ththe16_0043	ENOG4105KJJ	Uncharacterized ACR, COG1993
Ththe16_0046	ENOG4107RVV	histidinol phosphate phosphatase, hisj family
Ththe16_0049	ENOG4106XMA	In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity)
Ththe16_0050	ENOG4105SYT	Methylenetetrahydrofolate reductase
Ththe16_0053	ENOG4105CZG	Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity)
Ththe16_0054	ENOG4105C8B	TIGR00159 family
Ththe16_0056	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
Ththe16_0057	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
Ththe16_0058	ENOG4105C21	Displays ATPase and GTPase activities (By similarity)
Ththe16_0059	ENOG4105CHW	UPF0052 protein
Ththe16_0068	ENOG4105BZ9	Cytochrome C oxidase, subunit I
Ththe16_0069	ENOG4105CV4	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)
Ththe16_0070	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
Ththe16_0073	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
Ththe16_0074	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
Ththe16_0075	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
Ththe16_0086	ENOG41061DF	Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity)
Ththe16_0088	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Ththe16_0090	ENOG41080TK	Universal stress protein
Ththe16_0093	ENOG4105PAD	Hydrolase
Ththe16_0094	ENOG4105KA4	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
Ththe16_0095	ENOG4108UKI	Enoyl-CoA hydratase
Ththe16_0096	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
Ththe16_0097	ENOG4105C7S	Dehydrogenase
Ththe16_0099	ENOG4105CDH	Citrulline--aspartate ligase
Ththe16_0100	ENOG4105CH7	arginosuccinase
Ththe16_0101	ENOG4105CH7	arginosuccinase
Ththe16_0104	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
Ththe16_0105	ENOG4105CKU	formyltetrahydrofolate synthetase
Ththe16_0107	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
Ththe16_0108	ENOG4105C89	phosphohexose isomerase
Ththe16_0110	ENOG4108RWN	rrna methyltransferase
Ththe16_0112	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
Ththe16_0113	ENOG4105CJ9	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)
Ththe16_0114	ENOG4105CTD	carboxy-peptidase
Ththe16_0118	ENOG4105K4H	Nlp p60 protein
Ththe16_0120	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
Ththe16_0122	ENOG4105BZY	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)
Ththe16_0123	ENOG4105E2Z	phosphate ABC transporter (Permease
Ththe16_0124	ENOG4105C8U	phosphate abc transporter
Ththe16_0126	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
Ththe16_0128	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
Ththe16_0129	ENOG4105G5W	regulator Fur family
Ththe16_0132	ENOG4105CY0	Metallo-Beta-Lactamase
Ththe16_0133	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Ththe16_0134	ENOG4105WDJ	50S ribosomal protein L33
Ththe16_0135	ENOG410683Z	Preprotein translocase SecE subunit
Ththe16_0136	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
Ththe16_0137	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
Ththe16_0138	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
Ththe16_0139	ENOG41082AW	Binds together with S18 to 16S ribosomal RNA (By similarity)
Ththe16_0140	ENOG4105Z8H	single-stranded DNA-binding protein
Ththe16_0141	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
Ththe16_0142	ENOG4105K9Q	Binds to the 23S rRNA (By similarity)
Ththe16_0143	ENOG4105DMF	Dehydrogenase
Ththe16_0144	ENOG4105E1F	short-chain dehydrogenase reductase
Ththe16_0145	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
Ththe16_0146	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
Ththe16_0157	ENOG4107QN2	dihydrolipoyl dehydrogenase
Ththe16_0160	ENOG4105ZVY	2-oxoisovalerate dehydrogenase, E1 component beta subunit
Ththe16_0161	ENOG4105CPP	Dehydrogenase, E1 component
Ththe16_0162	ENOG4107SUU	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)
Ththe16_0163	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
Ththe16_0166	ENOG4105HJX	Biotin- acetyl-CoA-carboxylase ligase
Ththe16_0167	ENOG4107V9E	glucose-1-phosphate thymidylyltransferase
Ththe16_0168	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Ththe16_0169	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
Ththe16_0171	ENOG4108UGV	hypoxanthine phosphoribosyltransferase
Ththe16_0172	ENOG4105FE9	pseudouridine synthase
Ththe16_0174	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
Ththe16_0177	ENOG4105DP4	dak2 domain fusion protein ylov
Ththe16_0180	ENOG4105D60	lipoprotein releasing system transmembrane protein
Ththe16_0181	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
Ththe16_0182	ENOG4108VZM	50s ribosomal protein L10
Ththe16_0183	ENOG4105C15	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Ththe16_0184	ENOG4105W8H	transhydrogenase (subunit alpha
Ththe16_0185	ENOG4108IIE	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)
Ththe16_0187	ENOG4108594	Permease of the drug metabolite transporter
Ththe16_0190	ENOG4105C0P	Mg chelatase subunit ChlI
Ththe16_0191	ENOG4108J2R	molybdopterin oxidoreductase
Ththe16_0192	ENOG4105EBR	Carboxylesterase
Ththe16_0193	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Ththe16_0195	ENOG4105CH5	extracellular solute-binding protein, family 7
Ththe16_0196	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Ththe16_0200	ENOG4105EEI	dihydropteroate synthase
Ththe16_0201	ENOG4105KRF	dihydroneopterin aldolase
Ththe16_0203	ENOG4108UGX	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)
Ththe16_0204	ENOG4108ZF3	Phosphatase
Ththe16_0206	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
Ththe16_0207	ENOG4107QSN	dihydrolipoamide acetyltransferase
Ththe16_0209	ENOG4105C0B	DNA polymerase III (alpha subunit)
Ththe16_0212	ENOG4108Z4U	Ferredoxin
Ththe16_0215	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
Ththe16_0216	ENOG4105C5R	Aminotransferase
Ththe16_0217	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
Ththe16_0218	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
Ththe16_0219	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
Ththe16_0222	ENOG4107Z3H	Transcriptional regulator, TetR family
Ththe16_0226	ENOG4105K8N	protein family UPF0079, ATPase
Ththe16_0227	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
Ththe16_0228	ENOG4105C8T	Leucyl-tRNA synthetase
Ththe16_0231	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
Ththe16_0232	ENOG4105EE6	Alcohol dehydrogenase zinc-binding domain protein
Ththe16_0233	ENOG4105WE2	aldehyde ferredoxin oxidoreductase
Ththe16_0238	ENOG4105I08	Pseudouridine synthase
Ththe16_0240	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Ththe16_0241	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Ththe16_0242	ENOG4105BZU	Histidine kinase
Ththe16_0243	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
Ththe16_0246	ENOG4105CDF	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity)
Ththe16_0248	ENOG4107QPV	Serine Threonine protein kinase
Ththe16_0249	ENOG4105KME	endoribonuclease L-psp
Ththe16_0252	ENOG4108Z11	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)
Ththe16_0253	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
Ththe16_0256	ENOG4105DHP	deoxycytidine triphosphate deaminase
Ththe16_0257	ENOG4108R5K	PPIases accelerate the folding of proteins (By similarity)
Ththe16_0258	ENOG4105C49	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
Ththe16_0259	ENOG4107ZZY	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)
Ththe16_0260	ENOG4105FE8	tRNA (Guanosine-2'-O-)-methyltransferase
Ththe16_0261	ENOG4105CM2	brancheD-chain amino acid aminotransferase
Ththe16_0262	ENOG4105DND	Transcriptional regulator
Ththe16_0263	ENOG4105WEF	catalase
Ththe16_0265	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
Ththe16_0266	ENOG4108UW5	maltose o-acetyltransferase
Ththe16_0267	ENOG4105SFS	phosphoesterase RecJ domain protein
Ththe16_0269	ENOG4105E3H	phosphoglycerate mutase
Ththe16_0270	ENOG4107R1M	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) (By similarity)
Ththe16_0275	ENOG4105CVM	Molybdenum cofactor synthesis domain protein
Ththe16_0276	ENOG4105C1J	atp-dependent rna helicase
Ththe16_0285	ENOG4107EEN	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)
Ththe16_0286	ENOG4105C0H	protease
Ththe16_0287	ENOG4105C75	arginyL-tRNA synthetase
Ththe16_0288	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Ththe16_0289	ENOG4107WFQ	NADH-quinone oxidoreductase, chain M
Ththe16_0290	ENOG4105D65	subunit l
Ththe16_0291	ENOG4105M5H	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Ththe16_0292	ENOG41087XN	oxidoreductase
Ththe16_0293	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Ththe16_0294	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
Ththe16_0295	ENOG4108IEH	NADH dehydrogenase subunit g
Ththe16_0296	ENOG4107EEP	NADH dehydrogenase (quinone) (EC 1.6.99.5)
Ththe16_0297	ENOG4105GKE	subunit e
Ththe16_0298	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Ththe16_0299	ENOG4105CYU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Ththe16_0300	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
Ththe16_0301	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Ththe16_0302	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
Ththe16_0304	ENOG4105VIZ	double-strand break repair protein
Ththe16_0309	ENOG4105ECY	inositol monophosphatase
Ththe16_0310	ENOG4108ZGB	N-(5'-phosphoribosyl)anthranilate isomerase
Ththe16_0311	ENOG4107S45	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Ththe16_0312	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
Ththe16_0314	ENOG41073R8	VanW family
Ththe16_0315	ENOG4105CDA	abc transporter atp-binding protein
Ththe16_0321	ENOG4105EU8	FAD linked oxidase domain protein
Ththe16_0323	ENOG4105C25	Primosomal protein n'
Ththe16_0328	ENOG4108ZAF	Molybdopterin
Ththe16_0329	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
Ththe16_0331	ENOG4105BZU	Histidine kinase
Ththe16_0332	ENOG4105CB5	ATP-dependent DNA helicase recG
Ththe16_0333	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
Ththe16_0335	ENOG4105DGU	Histone deacetylase
Ththe16_0338	ENOG4105CBD	Diacylglycerol kinase
Ththe16_0341	ENOG4105CHM	Aminotransferase
Ththe16_0344	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
Ththe16_0345	ENOG4106633	50S ribosomal protein l28
Ththe16_0350	ENOG4105CPC	Aldo Keto reductase
Ththe16_0353	ENOG4105CUJ	penicillin amidase
Ththe16_0354	ENOG4106TD9	Diguanylate cyclase
Ththe16_0356	ENOG4105DAN	ATP-dependent protease
Ththe16_0357	ENOG4107QQ4	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
Ththe16_0359	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Ththe16_0360	ENOG4108ZHD	aig2 family
Ththe16_0361	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
Ththe16_0363	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
Ththe16_0364	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
Ththe16_0367	ENOG4105EAH	synthase
Ththe16_0369	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Ththe16_0370	ENOG41061TZ	Short-chain dehydrogenase reductase Sdr
Ththe16_0371	ENOG4105C3M	thioredoxin reductase
Ththe16_0372	ENOG4108DT4	serine threonine protein kinase
Ththe16_0373	ENOG410850P	UPF0102 protein
Ththe16_0374	ENOG4105D3H	Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)
Ththe16_0377	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
Ththe16_0378	ENOG4105F66	Binding-protein-dependent transport systems inner membrane component
Ththe16_0384	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
Ththe16_0385	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
Ththe16_0386	ENOG41067S4	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)
Ththe16_0387	ENOG4105DCX	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)
Ththe16_0388	ENOG4105CXR	Phospho-2-dehydro-3-deoxyoctonate aldolase
Ththe16_0399	ENOG4105E2A	Dehydrogenase
Ththe16_0405	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
Ththe16_0406	ENOG4105CCG	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)
Ththe16_0407	ENOG4105C34	Pseudouridine synthase
Ththe16_0410	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
Ththe16_0411	ENOG4105C4Q	deoxyguanosinetriphosphate triphosphohydrolase-like protein
Ththe16_0412	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
Ththe16_0413	ENOG4105VNB	Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity)
Ththe16_0414	ENOG4105CHR	reductase
Ththe16_0415	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
Ththe16_0416	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Ththe16_0417	ENOG41067VY	50S ribosomal protein L32
Ththe16_0425	ENOG4108TVJ	Nitroreductase
Ththe16_0428	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Ththe16_0429	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
Ththe16_0430	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
Ththe16_0431	ENOG4107Y7Q	pfkb domain protein
Ththe16_0432	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
Ththe16_0437	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
Ththe16_0439	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
Ththe16_0440	ENOG4108IUZ	ABC transporter
Ththe16_0442	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
Ththe16_0444	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
Ththe16_0445	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
Ththe16_0446	ENOG4107K5T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
Ththe16_0447	ENOG4105C0Z	ABC transporter
Ththe16_0448	ENOG4108IQE	Amp-dependent synthetase and ligase
Ththe16_0449	ENOG4105C32	Amino acid ABC transporter (Permease)
Ththe16_0450	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Ththe16_0452	ENOG4108IV0	ABC, transporter
Ththe16_0453	ENOG4105DIK	(ABC) transporter
Ththe16_0454	ENOG4105CC5	ABC transporter
Ththe16_0456	ENOG4107QI6	Cysteine desulfurase
Ththe16_0457	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
Ththe16_0458	ENOG4105CAT	Cytidine monophosphate kinase
Ththe16_0459	ENOG4108Y5D	Inherit from COG: cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
Ththe16_0461	ENOG4105CHR	reductase
Ththe16_0465	ENOG4105CAY	ferredoxin--nadp reductase
Ththe16_0467	ENOG4107QRA	Extracellular solute-binding protein, family 5
Ththe16_0469	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Ththe16_0472	ENOG41080XP	Cbs domain
Ththe16_0473	ENOG4105DGU	Histone deacetylase
Ththe16_0474	ENOG4106C07	ThiamineS Protein
Ththe16_0475	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
Ththe16_0476	ENOG4105CG3	alpha amylase, catalytic region
Ththe16_0478	ENOG4105C1K	alpha-alpha-trehalose-phosphate synthase
Ththe16_0480	ENOG4108HQS	Glycine betaine
Ththe16_0481	ENOG4108IJ7	Glycine betaine
Ththe16_0482	ENOG4105CG3	alpha amylase, catalytic region
Ththe16_0483	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Ththe16_0484	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Ththe16_0486	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
Ththe16_0489	ENOG4105D6E	homoserine dehydrogenase
Ththe16_0496	ENOG4106YGA	NADH dehydrogenase (quinone)
Ththe16_0497	ENOG4105CSA	Coproporphyrinogen iii oxidase
Ththe16_0502	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Ththe16_0504	ENOG4105CQB	FAD linked oxidase domain protein
Ththe16_0505	ENOG4107QP3	malate synthase g
Ththe16_0506	ENOG4107HP6	Transcriptional regulator
Ththe16_0507	ENOG4105KNI	merR family transcriptional Regulator
Ththe16_0508	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
Ththe16_0509	ENOG4108Z7R	Chaperone CsaA
Ththe16_0510	ENOG4105DZS	Phenylacetate-CoA ligase
Ththe16_0512	ENOG4105CY8	phosphoribosylaminoimidazole carboxylase atpase subunit
Ththe16_0513	ENOG4108UM6	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)
Ththe16_0517	ENOG4107TS3	membrane protein, TerC
Ththe16_0518	ENOG4105VG1	fes assembly suf system protein
Ththe16_0519	ENOG4107R1I	NAD-dependent malic enzyme
Ththe16_0522	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
Ththe16_0523	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
Ththe16_0524	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ththe16_0525	ENOG4105CBI	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ththe16_0526	ENOG4105DTN	riboflavin biosynthesis protein ribF
Ththe16_0527	ENOG4105EJF	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity)
Ththe16_0531	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
Ththe16_0532	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
Ththe16_0533	ENOG4105CFH	Aspartokinase
Ththe16_0535	ENOG4105D9Z	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Ththe16_0536	ENOG4105CH8	Succinyl-CoA ligase ADP-forming subunit alpha
Ththe16_0537	ENOG4105CMV	Succinyl-CoA synthetase subunit beta
Ththe16_0538	ENOG4108JVH	Protein of unknown function DUF43
Ththe16_0539	ENOG4105CTP	PilT protein domain protein
Ththe16_0540	ENOG4105DNJ	May play a role in the repair of endogenous alkylation damage (By similarity)
Ththe16_0542	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
Ththe16_0549	ENOG4105CX6	glutaminyL-tRNA synthetase
Ththe16_0551	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
Ththe16_0552	ENOG410868C	50s ribosomal protein l35
Ththe16_0553	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
Ththe16_0555	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Ththe16_0556	ENOG41080X4	futalosine nucleosidase
Ththe16_0557	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
Ththe16_0558	ENOG4105C9Q	fumarate hydratase class II
Ththe16_0564	ENOG4105CB1	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)
Ththe16_0565	ENOG4105DFA	alanine racemase domain protein
Ththe16_0568	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
Ththe16_0569	ENOG4105VSY	K01512 acylphosphatase EC 3.6.1.7
Ththe16_0571	ENOG4105CPQ	Dehydrogenase
Ththe16_0574	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
Ththe16_0575	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Ththe16_0576	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
Ththe16_0580	ENOG4105DBI	uridine monophosphokinase
Ththe16_0581	ENOG4108IJ9	(ABC) transporter
Ththe16_0584	ENOG4108UIC	UPF0340 protein
Ththe16_0587	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Ththe16_0589	ENOG4105C0Z	ABC transporter
Ththe16_0590	ENOG4108IV0	ABC, transporter
Ththe16_0596	ENOG4105CH5	extracellular solute-binding protein, family 7
Ththe16_0597	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
Ththe16_0598	ENOG4105DSE	periplasmic solute binding protein
Ththe16_0601	ENOG4105C1Q	protoporphyrinogen oxidase
Ththe16_0602	ENOG4107QME	Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)
Ththe16_0603	ENOG4105CFZ	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)
Ththe16_0606	ENOG4107UUG	Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity)
Ththe16_0608	ENOG4105CEY	Amp-dependent synthetase and ligase
Ththe16_0609	ENOG4105DXM	phenylacetic acid degradation protein
Ththe16_0610	ENOG4105C1G	acyl-Coa dehydrogenase
Ththe16_0613	ENOG4108Z2X	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)
Ththe16_0615	ENOG41066UU	tRNA (Adenine-N1-)-methyltransferase
Ththe16_0617	ENOG4105X0R	protein from nitrogen regulatory protein P-II
Ththe16_0618	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
Ththe16_0620	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
Ththe16_0621	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
Ththe16_0622	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
Ththe16_0623	ENOG4105DAP	Nicotinate phosphoribosyltransferase
Ththe16_0624	ENOG4105C3R	Methionine synthase
Ththe16_0627	ENOG4108UKH	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
Ththe16_0630	ENOG4105D48	metallophosphoesterase
Ththe16_0631	ENOG4105CCA	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)
Ththe16_0632	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
Ththe16_0635	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
Ththe16_0636	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
Ththe16_0646	ENOG4107SBE	Glycosyl transferase (Group 1
Ththe16_0649	ENOG4105K64	Glycosyl transferase, family 2
Ththe16_0657	ENOG4105D1F	ATP-binding protein
Ththe16_0659	ENOG4105F59	Methylates ribosomal protein L11 (By similarity)
Ththe16_0669	ENOG4107RIQ	Sulfate adenylate transferase
Ththe16_0670	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Ththe16_0671	ENOG4107TSN	permease
Ththe16_0672	ENOG4105ET3	Reduction of activated sulfate into sulfite (By similarity)
Ththe16_0673	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Ththe16_0674	ENOG4105EXQ	uroporphyrinogen iii synthase hem4
Ththe16_0675	ENOG4105ET1	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)
Ththe16_0676	ENOG4108UV6	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)
Ththe16_0677	ENOG4108G2S	Thiamine biosynthesis protein thiS
Ththe16_0678	ENOG4105CA8	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)
Ththe16_0680	ENOG4105CBF	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity)
Ththe16_0681	ENOG41079KZ	Major Facilitator Superfamily
Ththe16_0682	ENOG4105DWF	phosphomethylpyrimidine kinase
Ththe16_0690	ENOG4105E2R	ROK family
Ththe16_0691	ENOG4105CHU	acetyl-coa acetyltransferase
Ththe16_0695	ENOG4108IV0	ABC, transporter
Ththe16_0696	ENOG4105C0Z	ABC transporter
Ththe16_0698	ENOG4105C32	Amino acid ABC transporter (Permease)
Ththe16_0700	ENOG4108Z7G	MaoC domain protein dehydratase
Ththe16_0702	ENOG4105D3C	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity)
Ththe16_0703	ENOG4105CEY	Amp-dependent synthetase and ligase
Ththe16_0704	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
Ththe16_0706	ENOG4105C3D	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)
Ththe16_0708	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
Ththe16_0710	ENOG4105CHV	Transcription elongation factor NusA
Ththe16_0711	ENOG410836C	Required for maturation of 30S ribosomal subunits (By similarity)
Ththe16_0713	ENOG4105CD9	Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)
Ththe16_0714	ENOG4107YCR	Transcriptional regulator, ARSR family
Ththe16_0715	ENOG4105C59	p-type ATPase
Ththe16_0717	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
Ththe16_0719	ENOG4105C5S	asparaginyl-tRNA synthetase
Ththe16_0721	ENOG4107ZY0	Phenazine biosynthesis-like protein
Ththe16_0722	ENOG4105C9M	aspartyl-trna synthetase
Ththe16_0723	ENOG4105CUT	histidyl-tRNA synthetase
Ththe16_0726	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Ththe16_0727	ENOG4105E0C	molybdate abc transporter
Ththe16_0728	ENOG4108S6J	ABC transporter, periplasmic molybdate-binding protein
Ththe16_0729	ENOG4108UN4	phage SPO1 DNA polymerase-related protein
Ththe16_0733	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
Ththe16_0736	ENOG4108KGH	TRANSCRIPTIONal
Ththe16_0737	ENOG4107QM5	aconitate hydratase
Ththe16_0740	ENOG4105BZS	acriflavin resistance protein
Ththe16_0746	ENOG4105KG3	cytidine deaminase
Ththe16_0748	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Ththe16_0752	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
Ththe16_0754	ENOG4105EHG	Permease protein
Ththe16_0757	ENOG4105CHR	reductase
Ththe16_0759	ENOG4107S1E	Beta-lactamase
Ththe16_0762	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
Ththe16_0763	ENOG4105F6J	Alpha beta hydrolase fold
Ththe16_0766	ENOG4105DWV	Homoserine O-trans-acetylase
Ththe16_0767	ENOG4108IQK	o-acetylhomoserine
Ththe16_0770	ENOG4107WTH	Galactitol-1-phosphate dehydrogenase
Ththe16_0772	ENOG4105KXX	peptidase s58 dmpa
Ththe16_0774	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Ththe16_0775	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
Ththe16_0776	ENOG4105D7T	ABC transporter
Ththe16_0777	ENOG4105D2X	ABC transporter substrate-binding protein
Ththe16_0779	ENOG4107QYT	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity)
Ththe16_0788	ENOG4105C5I	Dehydrogenase
Ththe16_0791	ENOG4105CMS	peptidase U62, modulator of DNA gyrase
Ththe16_0792	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
Ththe16_0794	ENOG4105C1G	acyl-Coa dehydrogenase
Ththe16_0795	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
Ththe16_0797	ENOG4105K8I	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)
Ththe16_0798	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Ththe16_0802	ENOG4105CQB	FAD linked oxidase domain protein
Ththe16_0803	ENOG4105BZU	Histidine kinase
Ththe16_0805	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
Ththe16_0806	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
Ththe16_0807	ENOG4108YYC	ycei family
Ththe16_0808	ENOG4108XHF	Pfam:DUF178
Ththe16_0809	ENOG4105DVY	radical SAM domain protein
Ththe16_0812	ENOG4105ETE	Transcriptional regulator (LacI family
Ththe16_0813	ENOG41071YG	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Ththe16_0814	ENOG4105ERH	Fumarylacetoacetate hydrolase
Ththe16_0816	ENOG4108V3E	phosphoribosylglycinamide formyltransferase
Ththe16_0817	ENOG4107QNG	Phosphoribosylglycinamide synthetase
Ththe16_0818	ENOG4108IRC	dna polymerase iii
Ththe16_0820	ENOG4105BZU	Histidine kinase
Ththe16_0824	ENOG4107QN1	sodium solute
Ththe16_0826	ENOG4105CDY	transcriptional regulatory protein
Ththe16_0827	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
Ththe16_0828	ENOG4107ZQN	disulfide bond
Ththe16_0829	ENOG4105CCX	Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)
Ththe16_0830	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Ththe16_0831	ENOG4105CNU	cell division protein FtsK
Ththe16_0834	ENOG4105W87	Cbs domain
Ththe16_0836	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Ththe16_0838	ENOG4108Z4T	Peptidase M50
Ththe16_0839	ENOG4105EFU	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)
Ththe16_0841	ENOG41082J7	Rhodanese domain protein
Ththe16_0844	ENOG4105M78	Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity)
Ththe16_0846	ENOG4105ED1	spovr family
Ththe16_0847	ENOG4106AKX	UPF0229 protein
Ththe16_0848	ENOG4105CYN	Serine protein kinase
Ththe16_0855	ENOG4105MCT	stage V sporulation protein S
Ththe16_0856	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Ththe16_0857	ENOG4105II7	pyrroline-5-carboxylate reductase
Ththe16_0859	ENOG4105C3Q	Glycosyl transferase, family 2
Ththe16_0860	ENOG4105DZP	Membrane-associated zinc metalloprotease
Ththe16_0861	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
Ththe16_0862	ENOG4105KNE	Phosphatidate cytidylyltransferase
Ththe16_0863	ENOG4108VCV	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)
Ththe16_0864	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
Ththe16_0865	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
Ththe16_0866	ENOG4105CE9	30S ribosomal protein S2
Ththe16_0867	ENOG4108JPW	Aminotransferase
Ththe16_0868	ENOG4108YZ4	nudix hydrolase
Ththe16_0871	ENOG4105KHN	chorismate mutase
Ththe16_0872	ENOG4105T1M	mycothiol conjugate amidase mca
Ththe16_0874	ENOG4107Y3Y	amidohydrolase
Ththe16_0876	ENOG4105DTQ	mandelate racemase muconate lactonizing
Ththe16_0877	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
Ththe16_0879	ENOG4108UQV	Membrane
Ththe16_0880	ENOG4105CWG	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)
Ththe16_0883	ENOG4108SHN	Glycosyl transferase, family 2
Ththe16_0884	ENOG4107V8I	Glycosyl transferases group 1
Ththe16_0887	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Ththe16_0892	ENOG4105CHU	acetyl-coa acetyltransferase
Ththe16_0893	ENOG4105C1G	acyl-Coa dehydrogenase
Ththe16_0894	ENOG4105C8N	cysteinyl-tRNA synthetase
Ththe16_0895	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
Ththe16_0896	ENOG41068KF	Universal stress protein
Ththe16_0898	ENOG4108FXY	Cys/Met metabolism PLP-dependent enzyme
Ththe16_0902	ENOG4105CDB	Required for chromosome condensation and partitioning (By similarity)
Ththe16_0904	ENOG4105C5C	n-acetylmuramoyl-l-alanine amidase
Ththe16_0905	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
Ththe16_0907	ENOG4107ZYJ	bioY protein
Ththe16_0908	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
Ththe16_0909	ENOG4105BZA	Phosphoglycerate kinase
Ththe16_0912	ENOG4105C8Y	Acetylornithine aminotransferase
Ththe16_0913	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
Ththe16_0914	ENOG41081CK	Memo-like protein
Ththe16_0915	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
Ththe16_0916	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
Ththe16_0918	ENOG4106H78	methyltransferase
Ththe16_0919	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
Ththe16_0920	ENOG4105DC1	bifunctional purine biosynthesis protein purh
Ththe16_0921	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
Ththe16_0923	ENOG4105CDM	Glutamate-1-semialdehyde aminotransferase
Ththe16_0930	ENOG4108IJ6	ABC transporter
Ththe16_0938	ENOG4105CP7	Triose-phosphate isomerase
Ththe16_0939	ENOG4105ECK	Fatty Acid Desaturase
Ththe16_0940	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
Ththe16_0941	ENOG4105EPR	degv family
Ththe16_0942	ENOG4105EPR	degv family
Ththe16_0944	ENOG410600Z	Regulatory protein MarR
Ththe16_0948	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Ththe16_0951	ENOG4108ZFX	Mannosyl-3-phosphoglycerate phosphatase
Ththe16_0953	ENOG4105CDP	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)
Ththe16_0955	ENOG4105C26	Dehydrogenase
Ththe16_0956	ENOG4105EFA	4-hydroxyphenylacetate
Ththe16_0957	ENOG4105MXW	flavin reductase domain protein, FMN-binding
Ththe16_0960	ENOG4105C32	Amino acid ABC transporter (Permease)
Ththe16_0961	ENOG4105C0Z	ABC transporter
Ththe16_0962	ENOG4108IV0	ABC, transporter
Ththe16_0963	ENOG4107YAU	phenylacetic acid degradation protein
Ththe16_0964	ENOG4105DZS	Phenylacetate-CoA ligase
Ththe16_0969	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
Ththe16_0973	ENOG4105JNK	Glycosyl transferase (Group 1
Ththe16_0975	ENOG4107R5M	Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity)
Ththe16_0976	ENOG4108UHC	Glycosyl transferase, wecb taga cpsf family
Ththe16_0981	ENOG4105D3Q	Sugar transferase
Ththe16_0983	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
Ththe16_0986	ENOG4105DXM	phenylacetic acid degradation protein
Ththe16_0990	ENOG4105CRS	phenylacetate-CoA oxygenase PaaG subunit
Ththe16_0991	ENOG4108RZE	Tetr family transcriptional regulator
Ththe16_0992	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Ththe16_0998	ENOG4107NFR	Fructose-1,6-bisphosphatase
Ththe16_1000	ENOG4108UQY	Iron-storage protein
Ththe16_1001	ENOG4108IYU	L-aspartate oxidase
Ththe16_1002	ENOG4105D0I	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)
Ththe16_1003	ENOG4105D18	nicotinate-nucleotide pyrophosphorylase
Ththe16_1004	ENOG4105C7Z	Conserved Protein
Ththe16_1005	ENOG4105CHU	acetyl-coa acetyltransferase
Ththe16_1006	ENOG4105P4J	Allophanate hydrolase, subunit 1
Ththe16_1007	ENOG4105C0R	drug resistance transporter emrb qaca subfamily
Ththe16_1010	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Ththe16_1013	ENOG4105C26	Dehydrogenase
Ththe16_1016	ENOG4105C4R	Atp-dependent dna helicase
Ththe16_1019	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
Ththe16_1020	ENOG4106F60	Histidine kinase
Ththe16_1023	ENOG4105ENT	Efflux transporter rnd family, mfp subunit
Ththe16_1024	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Ththe16_1025	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Ththe16_1039	ENOG4105EYG	tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity)
Ththe16_1040	ENOG4105KHC	sulfurtransferase
Ththe16_1041	ENOG4105EJQ	L-serine dehydratase
Ththe16_1042	ENOG4105WH1	Two component transcriptional regulator luxr family
Ththe16_1043	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
Ththe16_1044	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
Ththe16_1045	ENOG4106GF2	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
Ththe16_1046	ENOG4105VB6	UPF0109 protein
Ththe16_1047	ENOG4105K5M	30s ribosomal protein S16
Ththe16_1048	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Ththe16_1053	ENOG4105CRK	lysyL-tRNA synthetase
Ththe16_1054	ENOG4105RTX	GreA GreB family elongation factor
Ththe16_1056	ENOG41080IJ	Diacylglycerol kinase
Ththe16_1057	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
Ththe16_1058	ENOG4105C9A	Phoh family
Ththe16_1060	ENOG4105DI5	UPF0365 protein
Ththe16_1062	ENOG4105E2X	shikimate dehydrogenase
Ththe16_1066	ENOG4105C2M	dna polymerase I
Ththe16_1067	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
Ththe16_1069	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
Ththe16_1071	ENOG4105CJW	magnesium transporter
Ththe16_1073	ENOG4105C66	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)
Ththe16_1075	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
Ththe16_1076	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
Ththe16_1077	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
Ththe16_1078	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
Ththe16_1079	ENOG4105DC7	peptidase M24
Ththe16_1081	ENOG4105FRN	stage II sporulation protein
Ththe16_1083	ENOG4105C35	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)
Ththe16_1084	ENOG41082DI	50s ribosomal protein l31
Ththe16_1085	ENOG4108V6E	Cell division protein mraZ
Ththe16_1086	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
Ththe16_1088	ENOG4105CJN	penicillin-binding protein
Ththe16_1089	ENOG4107EES	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity)
Ththe16_1091	ENOG4105CPY	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity)
Ththe16_1092	ENOG4105DMZ	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)
Ththe16_1093	ENOG4105CNI	cell division protein FtsW
Ththe16_1094	ENOG4105DVQ	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)
Ththe16_1095	ENOG4105DFU	Cell wall formation (By similarity)
Ththe16_1096	ENOG4107QWW	Cell wall formation (By similarity)
Ththe16_1098	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
Ththe16_1100	ENOG4105NHU	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)
Ththe16_1102	ENOG4105DKF	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)
Ththe16_1104	ENOG4105F6H	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)
Ththe16_1105	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
Ththe16_1106	ENOG4107R2U	Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)
Ththe16_1107	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
Ththe16_1108	ENOG4105DIH	basic membrane
Ththe16_1109	ENOG4108JQ9	ABC transporter
Ththe16_1119	ENOG4105CPK	Glycosyl transferase (Group 1
Ththe16_1120	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
Ththe16_1122	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
Ththe16_1123	ENOG4108SA1	esterase
Ththe16_1126	ENOG4105DF6	Fe-S oxidoreductase
Ththe16_1129	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
Ththe16_1130	ENOG41082MB	Involved in the transcription termination process (By similarity)
Ththe16_1132	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
Ththe16_1133	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
Ththe16_1134	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
Ththe16_1137	ENOG4105F6J	Alpha beta hydrolase fold
Ththe16_1138	ENOG4105CYW	agmatinase
Ththe16_1141	ENOG4105CXV	gliding motility protein
Ththe16_1143	ENOG4105NAA	Cytochrome C oxidase, subunit II
Ththe16_1144	ENOG4107RQ2	Cytochrome c oxidase, subunit I
Ththe16_1146	ENOG4107RGD	Major Facilitator superfamily
Ththe16_1148	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
Ththe16_1149	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Ththe16_1150	ENOG4105CN5	Metallo-Beta-Lactamase
Ththe16_1151	ENOG4105C52	Atpase, p-type (Transporting), had superfamily, subfamily ic
Ththe16_1152	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
Ththe16_1153	ENOG4105BZU	Histidine kinase
Ththe16_1154	ENOG4105C1G	acyl-Coa dehydrogenase
Ththe16_1155	ENOG4105BZJ	Electron transfer flavoprotein
Ththe16_1156	ENOG4105C10	Electron transfer flavoprotein
Ththe16_1158	ENOG4108HNZ	carboxyl transferase
Ththe16_1159	ENOG4105E50	uracil-dna glycosylase
Ththe16_1160	ENOG4105DCG	PHP domain protein
Ththe16_1164	ENOG4105C88	aminopeptidase
Ththe16_1168	ENOG4108FXY	Cys/Met metabolism PLP-dependent enzyme
Ththe16_1175	ENOG4105D78	K07001 NTE family protein
Ththe16_1176	ENOG4105VT3	DNA binding domain protein, excisionase family
Ththe16_1178	ENOG4105DK0	Indole-3-glycerol phosphate synthase
Ththe16_1179	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Ththe16_1181	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
Ththe16_1183	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Ththe16_1184	ENOG4105E5Q	amino acid AbC transporter
Ththe16_1185	ENOG4105EAB	amino acid AbC transporter
Ththe16_1187	ENOG4105D37	Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)
Ththe16_1188	ENOG4105C1A	potassium transporter peripheral membrane
Ththe16_1189	ENOG4105CBM	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity)
Ththe16_1190	ENOG4105HSZ	Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)
Ththe16_1194	ENOG4105KJF	protein tyrosine phosphatase
Ththe16_1196	ENOG4105CVS	RNA methyltransferase TrmH family, group 1
Ththe16_1200	ENOG4105C3G	gtp-binding protein
Ththe16_1201	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
Ththe16_1203	ENOG4108Z03	MAF-like protein
Ththe16_1206	ENOG4105CJN	penicillin-binding protein
Ththe16_1207	ENOG4107YDG	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)
Ththe16_1212	ENOG4105C5V	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)
Ththe16_1213	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Ththe16_1215	ENOG4105DBV	ornithine carbamoyltransferase
Ththe16_1217	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
Ththe16_1219	ENOG4105CJ1	ABC, transporter
Ththe16_1222	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Ththe16_1224	ENOG4105CYQ	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)
Ththe16_1225	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
Ththe16_1226	ENOG4108ZP8	Acetolactate synthase small subunit
Ththe16_1227	ENOG4105C7K	acetolactate synthase
Ththe16_1228	ENOG4105E4T	pyridine nucleotide-disulfide oxidoreductase
Ththe16_1242	ENOG4105C31	Tryptophanyl-tRNA synthetase
Ththe16_1244	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Ththe16_1245	ENOG4105MQS	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Ththe16_1246	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Ththe16_1250	ENOG4105C01	Dihydroxy-acid dehydratase
Ththe16_1252	ENOG4107RUE	extracellular solute-binding protein family 1
Ththe16_1253	ENOG4105D38	putrescine abc transporter
Ththe16_1254	ENOG4105F38	ABC transporter, permease
Ththe16_1255	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Ththe16_1256	ENOG4105CNI	cell division protein FtsW
Ththe16_1257	ENOG4108CHF	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
Ththe16_1258	ENOG4107QMS	site-determining protein
Ththe16_1263	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Ththe16_1264	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Ththe16_1265	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
Ththe16_1266	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
Ththe16_1270	ENOG4105K8R	UPF0145 protein
Ththe16_1271	ENOG4108I5C	dEAD DEAH box helicase
Ththe16_1274	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
Ththe16_1275	ENOG4107SBB	4-alpha-glucanotransferase (EC 2.4.1.25)
Ththe16_1276	ENOG4105DYT	3-hydroxyacyl-CoA dehydrogenase
Ththe16_1277	ENOG4107Y9U	Membrane
Ththe16_1278	ENOG4105C1V	Peptidase, M16
Ththe16_1283	ENOG4105M56	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Ththe16_1284	ENOG4108JIP	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)
Ththe16_1285	ENOG4108JIQ	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)
Ththe16_1286	ENOG410704R	Produces ATP from ADP in the presence of a proton gradient across the membrane
Ththe16_1287	ENOG41089ID	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
Ththe16_1290	ENOG4105EBX	v-type atpase
Ththe16_1295	ENOG4105E8R	UPF0173 metal-dependent hydrolase
Ththe16_1296	ENOG4107QPV	Serine Threonine protein kinase
Ththe16_1297	ENOG4108IQF	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)
Ththe16_1298	ENOG4105CJR	Integral membrane protein (MviN
Ththe16_1300	ENOG4105EYH	Exonuclease
Ththe16_1305	ENOG4105MS2	ribosomal subunit Interface protein
Ththe16_1306	ENOG4105CAK	Cell division ATP-binding protein ftsE
Ththe16_1307	ENOG4105CN1	protease
Ththe16_1309	ENOG4105CKH	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)
Ththe16_1310	ENOG4105E66	phosphoriboisomerase A
Ththe16_1311	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ththe16_1314	ENOG4105UIB	(ABC) transporter
Ththe16_1315	ENOG4105C2J	ABC transporter
Ththe16_1316	ENOG41080QG	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)
Ththe16_1319	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Ththe16_1323	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
Ththe16_1324	ENOG4105ESV	Glycosyl transferase, family 4
Ththe16_1325	ENOG4105EAG	UDP-N-acetylglucosamine 2-epimerase
Ththe16_1332	ENOG4105C0H	protease
Ththe16_1333	ENOG4105CIY	formyltetrahydrofolate deformylase
Ththe16_1334	ENOG4108YYX	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)
Ththe16_1335	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
Ththe16_1336	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
Ththe16_1338	ENOG41067HZ	cytochrome C, class I
Ththe16_1340	ENOG4105CGH	5'-nucleotidase
Ththe16_1341	ENOG4105C5F	glutamine synthetase
Ththe16_1343	ENOG4105C32	Amino acid ABC transporter (Permease)
Ththe16_1344	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
Ththe16_1345	ENOG4105C0Z	ABC transporter
Ththe16_1346	ENOG4108IV0	ABC, transporter
Ththe16_1347	ENOG4105DEF	Extracellular solute-binding protein, family 5
Ththe16_1348	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Ththe16_1349	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Ththe16_1351	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
Ththe16_1352	ENOG4105BZ1	(ABC) transporter
Ththe16_1353	ENOG4105BZ1	(ABC) transporter
Ththe16_1354	ENOG4105BZN	citrate synthase
Ththe16_1355	ENOG4105D06	uba thif-type nad fad binding protein
Ththe16_1356	ENOG4105DG6	mannose-6-phosphate isomerase
Ththe16_1358	ENOG4105Y7X	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)
Ththe16_1360	ENOG4105K70	DNA-binding protein
Ththe16_1363	ENOG4105WH1	Two component transcriptional regulator luxr family
Ththe16_1364	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
Ththe16_1365	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
Ththe16_1366	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Ththe16_1367	ENOG4105VF7	tolerance protein
Ththe16_1370	ENOG4108W63	CRP FNR family transcriptional regulator
Ththe16_1374	ENOG4105BZU	Histidine kinase
Ththe16_1375	ENOG4105CHG	glycolate oxidase (iron-sulfur subunit)
Ththe16_1376	ENOG4107QR9	Iron-sulfur cluster binding protein
Ththe16_1377	ENOG4108ZZK	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)
Ththe16_1379	ENOG4105D78	K07001 NTE family protein
Ththe16_1380	ENOG4105D9P	serine threonine protein kinase
Ththe16_1383	ENOG4107QNB	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
Ththe16_1386	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
Ththe16_1388	ENOG4105C0C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity)
Ththe16_1394	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
Ththe16_1395	ENOG4107ZC0	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)
Ththe16_1396	ENOG4105D49	3-dehydroquinate synthase
Ththe16_1397	ENOG4105CYJ	ribosomal RNA small subunit methyltransferase B
Ththe16_1398	ENOG41084ZW	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
Ththe16_1401	ENOG4105DKZ	GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity)
Ththe16_1402	ENOG4105NDF	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity)
Ththe16_1403	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
Ththe16_1404	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
Ththe16_1407	ENOG4108AH5	Binds directly to 16S ribosomal RNA (By similarity)
Ththe16_1409	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
Ththe16_1412	ENOG4105KWW	Biogenesis protein
Ththe16_1413	ENOG4107QX9	Thiol disulfide interChange protein
Ththe16_1414	ENOG4105DA4	cytochrome c-type biogenesis protein
Ththe16_1415	ENOG4108ZKK	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)
Ththe16_1417	ENOG41060IM	Heme exporter protein
Ththe16_1418	ENOG4105CA5	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)
Ththe16_1419	ENOG4107EV4	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)
Ththe16_1420	ENOG4107QIV	Cytochrome c biogenesis protein
Ththe16_1421	ENOG4105NQN	cytochrome C
Ththe16_1423	ENOG4107S7U	Sulfide dehydrogenase
Ththe16_1426	ENOG4105QN4	diheme cytochrome
Ththe16_1427	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
Ththe16_1428	ENOG4105CGH	5'-nucleotidase
Ththe16_1429	ENOG4108XRS	Monoheme cytochrome SoxX (Sulfur oxidation)
Ththe16_1430	ENOG4105QN4	diheme cytochrome
Ththe16_1434	ENOG41067HZ	cytochrome C, class I
Ththe16_1435	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Ththe16_1439	ENOG4107QKV	phosphomannomutase
Ththe16_1441	ENOG4105CEY	Amp-dependent synthetase and ligase
Ththe16_1442	ENOG4105WKW	Pfam:DUF1458
Ththe16_1445	ENOG4105E39	Enoyl-CoA hydratase
Ththe16_1446	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
Ththe16_1447	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
Ththe16_1448	ENOG4105IJJ	transcriptional regulator, crp fnr family
Ththe16_1449	ENOG4108N5B	2-phosphosulfolactate phosphatase
Ththe16_1451	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
Ththe16_1453	ENOG4108JIF	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
Ththe16_1455	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
Ththe16_1456	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
Ththe16_1457	ENOG4105CBT	Fructose-1,6-bisphosphatase
Ththe16_1458	ENOG4105DCF	alanine dehydrogenase
Ththe16_1459	ENOG4105CYC	Transferase
Ththe16_1460	ENOG4105F8V	Hydrolase, tatD family
Ththe16_1461	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
Ththe16_1463	ENOG4105C5S	asparaginyl-tRNA synthetase
Ththe16_1465	ENOG4105E33	succinate dehydrogenase
Ththe16_1469	ENOG4105X3E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)
Ththe16_1471	ENOG4105CIG	ABC transporter
Ththe16_1475	ENOG4105CEY	Amp-dependent synthetase and ligase
Ththe16_1476	ENOG4108UJD	30S ribosomal protein S9
Ththe16_1477	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
Ththe16_1478	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
Ththe16_1480	ENOG4105CBC	glutamate synthase
Ththe16_1482	ENOG4106YBV	Methyl-accepting chemotaxis
Ththe16_1483	ENOG4105CDU	Replicative dna helicase
Ththe16_1486	ENOG4105CJW	magnesium transporter
Ththe16_1490	ENOG4105NCW	Trka-c domain protein
Ththe16_1492	ENOG4108ZVP	Domain of unknown function (DUF1931)
Ththe16_1494	ENOG4105K63	Thioredoxin
Ththe16_1497	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ththe16_1506	ENOG4105C2Z	ATP-dependent CLP protease ATP-binding subunit
Ththe16_1507	ENOG4108FYC	transcriptional regulator MERR family
Ththe16_1508	ENOG4105DVC	DnaJ domain protein
Ththe16_1509	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Ththe16_1510	ENOG4105CFG	Acts as a chaperone (By similarity)
Ththe16_1511	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
Ththe16_1512	ENOG4105DR4	Methyltransferase
Ththe16_1513	ENOG4105D07	Signal peptide peptidase, SppA
Ththe16_1516	ENOG4108UKM	mov34 mpn pad-1 family protein
Ththe16_1517	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Ththe16_1518	ENOG4105C7R	Atpase associated with various cellular activities aaa_3
Ththe16_1519	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
Ththe16_1520	ENOG4108UT2	hemolysin iii
Ththe16_1522	ENOG41062D9	Histidine kinase
Ththe16_1526	ENOG4105C7E	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)
Ththe16_1528	ENOG4108Z8I	decarboxylase
Ththe16_1533	ENOG4105C83	adenylosuccinate lyase
Ththe16_1536	ENOG4105C8V	SAICAR synthetase
Ththe16_1538	ENOG4105D21	Phosphoribosylformylglycinamidine synthase I
Ththe16_1540	ENOG4107QIK	phosphoribosylformylglycinamidine synthase
Ththe16_1541	ENOG4105CBA	glutamine phosphoribosylpyrophosphate amidotransferase
Ththe16_1542	ENOG4108T9W	RNA methylase
Ththe16_1545	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
Ththe16_1546	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
Ththe16_1547	ENOG4105CBH	Hydroxymethylglutaryl-CoA lyase
Ththe16_1548	ENOG4105CIS	alcohol dehydrogenase
Ththe16_1552	ENOG4106NZV	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity)
Ththe16_1556	ENOG4108HMX	isocitrate dehydrogenase (NADP)
Ththe16_1562	ENOG4105KA0	thioesterase Superfamily protein
Ththe16_1563	ENOG4108IGT	Dipeptidase
Ththe16_1564	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
Ththe16_1565	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Ththe16_1566	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
Ththe16_1567	ENOG4106762	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)
Ththe16_1570	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
Ththe16_1572	ENOG41067KJ	GYD family
Ththe16_1573	ENOG4105I9P	Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity)
Ththe16_1574	ENOG4108UMW	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
Ththe16_1575	ENOG4107QX3	carboxylase
Ththe16_1576	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
Ththe16_1577	ENOG4105XBY	Regulates arginine biosynthesis genes (By similarity)
Ththe16_1578	ENOG4105CJS	Phosphopantothenoylcysteine decarboxylase
Ththe16_1579	ENOG41079SJ	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)
Ththe16_1580	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
Ththe16_1582	ENOG4105K85	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)
Ththe16_1583	ENOG4105JFG	SpoIID LytB domain protein
Ththe16_1584	ENOG41074B2	UPF0747 protein
Ththe16_1586	ENOG4105E63	Pfam:DUF178
Ththe16_1594	ENOG4105D82	Glutamate dehydrogenase
Ththe16_1595	ENOG4105D82	Glutamate dehydrogenase
Ththe16_1596	ENOG4105C26	Dehydrogenase
Ththe16_1597	ENOG41062BK	proline dehydrogenase
Ththe16_1603	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
Ththe16_1604	ENOG4105XEZ	This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the
Ththe16_1606	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
Ththe16_1607	ENOG4105CPF	Cell wall formation (By similarity)
Ththe16_1608	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
Ththe16_1609	ENOG4107UH2	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
Ththe16_1612	ENOG4105BZU	Histidine kinase
Ththe16_1613	ENOG4105ETX	regulatoR
Ththe16_1614	ENOG4105D9P	serine threonine protein kinase
Ththe16_1615	ENOG4108ZF3	Phosphatase
Ththe16_1618	ENOG4105D52	delta-aminolevulinic acid dehydratase
Ththe16_1619	ENOG41080DW	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
Ththe16_1620	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
Ththe16_1625	ENOG4105DRY	peptidase s9 prolyl oligopeptidase active site domain protein
Ththe16_1626	ENOG4107XF7	NGG1p interacting factor 3 protein, NIF3
Ththe16_1627	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
Ththe16_1631	ENOG4105MK2	5-formyltetrahydrofolate cyclo-ligase
Ththe16_1632	ENOG4105EJU	HAD-superfamily hydrolase subfamily IA variant 3
Ththe16_1637	ENOG4107YU2	histidine triad (hIT) protein
Ththe16_1638	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
Ththe16_1639	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
Ththe16_1640	ENOG4105C87	Aminotransferase class I and II
Ththe16_1641	ENOG4105VN1	Heat shock protein
Ththe16_1642	ENOG4105KHC	sulfurtransferase
Ththe16_1643	ENOG4105C5X	domain protein
Ththe16_1645	ENOG4108Z9K	Osmotically inducible protein
Ththe16_1648	ENOG4107QKW	extracellular solute-binding protein family 1
Ththe16_1650	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
Ththe16_1651	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
Ththe16_1652	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Ththe16_1655	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
Ththe16_1656	ENOG4105DC7	peptidase M24
Ththe16_1657	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
Ththe16_1660	ENOG4105DP5	Catalyzes the biosynthesis of agmatine from arginine (By similarity)
Ththe16_1661	ENOG4105BZU	Histidine kinase
Ththe16_1662	ENOG4105CPH	Catalyzes the formation of S-adenosylmethionine from methionine and ATP
Ththe16_1663	ENOG4105F03	Provides the (R)-glutamate required for cell wall biosynthesis (By similarity)
Ththe16_1664	ENOG4108URH	decarboxylase
Ththe16_1665	ENOG4105C98	muts2 protein
Ththe16_1666	ENOG4107R28	alpha amylase, catalytic region
Ththe16_1667	ENOG4105EG2	ABC transporter, permease
Ththe16_1668	ENOG4105D56	permease protein
Ththe16_1671	ENOG4108V82	Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)
Ththe16_1672	ENOG4105EAH	synthase
Ththe16_1681	ENOG4108ZT0	50S ribosomal protein l17
Ththe16_1682	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Ththe16_1683	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
Ththe16_1684	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
Ththe16_1685	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Ththe16_1686	ENOG41067V7	50S ribosomal protein L36
Ththe16_1687	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
Ththe16_1689	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
Ththe16_1690	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
Ththe16_1691	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
Ththe16_1692	ENOG410856V	50S ribosomal protein L30
Ththe16_1693	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
Ththe16_1694	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
Ththe16_1695	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
Ththe16_1696	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
Ththe16_1697	ENOG41082QR	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
Ththe16_1698	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Ththe16_1699	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
Ththe16_1700	ENOG4108UNN	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity)
Ththe16_1701	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
Ththe16_1702	ENOG4108CHD	50s ribosomal protein l29
Ththe16_1703	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
Ththe16_1704	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
Ththe16_1705	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
Ththe16_1706	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
Ththe16_1707	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Ththe16_1708	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
Ththe16_1709	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
Ththe16_1710	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
Ththe16_1711	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
Ththe16_1712	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
Ththe16_1713	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
Ththe16_1714	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
Ththe16_1715	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
Ththe16_1723	ENOG4105PW4	Sugar fermentation stimulation protein homolog
Ththe16_1730	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
Ththe16_1731	ENOG4107T9V	chlorite dismutase
Ththe16_1732	ENOG4105D8X	mechanosensitive ion channel
Ththe16_1734	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
Ththe16_1735	ENOG4105C59	p-type ATPase
Ththe16_1739	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
Ththe16_1740	ENOG4105EB3	Histidine kinase
Ththe16_1748	ENOG4107TZ2	Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity)
Ththe16_1751	ENOG4105C9B	Cysteine desulfurase
Ththe16_1752	ENOG4108UNV	SUF system FeS assembly protein, NifU family
Ththe16_1754	ENOG4108EMS	branched-chain alpha-keto acid dehydrogenase subunit E2
Ththe16_1756	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
Ththe16_1758	ENOG4107QV3	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity)
Ththe16_1759	ENOG4105SKN	orotidine 5''-phosphate decarboxylase
Ththe16_1760	ENOG4107YEI	lmbE family
Ththe16_1761	ENOG4106FU4	Archease protein family (MTH1598/TM1083)
Ththe16_1762	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
Ththe16_1763	ENOG4105K63	Thioredoxin
Ththe16_1764	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
Ththe16_1765	ENOG4105K8U	2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ththe16_1767	ENOG4105CPK	Glycosyl transferase (Group 1
Ththe16_1770	ENOG4105C8Y	Acetylornithine aminotransferase
Ththe16_1773	ENOG4108KB0	deacetylase
Ththe16_1774	ENOG4105BZU	Histidine kinase
Ththe16_1781	ENOG4107SFQ	iron-sulfur binding
Ththe16_1784	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
Ththe16_1785	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
Ththe16_1791	ENOG4105CZX	twitching motility protein
Ththe16_1792	ENOG4107QQT	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)
Ththe16_1797	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
Ththe16_1798	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ththe16_1799	ENOG4105K46	50S ribosomal protein l27
Ththe16_1800	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
Ththe16_1806	ENOG4108YXW	Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Ththe16_1808	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
Ththe16_1811	ENOG4105CBP	Major Facilitator
Ththe16_1812	ENOG4108ZPQ	MazG nucleotide pyrophosphohydrolase
Ththe16_1813	ENOG4108Z5K	methylglyoxal synthase
Ththe16_1815	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
Ththe16_1816	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
Ththe16_1820	ENOG41090A4	Pterin carbinolamine dehydratase
Ththe16_1823	ENOG4105ERD	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)
Ththe16_1824	ENOG4105E0C	molybdate abc transporter
Ththe16_1825	ENOG4105C4Y	ABC transporter
Ththe16_1828	ENOG4107QY0	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity)
Ththe16_1829	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Ththe16_1830	ENOG4107QIH	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
Ththe16_1832	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
Ththe16_1833	ENOG4105DFF	Rod shape-determining protein mreb
Ththe16_1834	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
Ththe16_1835	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
Ththe16_1836	ENOG4108784	2'-5' rna ligase
Ththe16_1837	ENOG4105CEV	competence damage-inducible protein
Ththe16_1838	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
Ththe16_1844	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
Ththe16_1846	ENOG4106B0N	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
Ththe16_1848	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
Ththe16_1850	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
Ththe16_1851	ENOG4108I0Y	(ABC) transporter
Ththe16_1852	ENOG4107QMW	pyridine nucleotide-disulfide oxidoreductase
Ththe16_1855	ENOG4105C3K	feS assembly ATPase SufC
Ththe16_1856	ENOG4105DIW	FeS assembly protein SUFB
Ththe16_1858	ENOG4105VQD	rieske 2fe-2S domain-containing protein
Ththe16_1859	ENOG4107QYG	anthranilate phosphoribosyltransferase
Ththe16_1860	ENOG4105DDQ	anthranilate synthase
Ththe16_1861	ENOG4105CRQ	synthase (Component I)
Ththe16_1866	ENOG4108UXE	Protein tyrosine phosphatase
Ththe16_1867	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
Ththe16_1868	ENOG4105UIB	(ABC) transporter
Ththe16_1872	ENOG4105MA4	psp1 domain protein
Ththe16_1873	ENOG4107QRG	dna polymerase iii
Ththe16_1879	ENOG4105C22	threonyL-tRNA synthetase
Ththe16_1882	ENOG4105EUJ	GTP cyclohydrolase i
Ththe16_1883	ENOG4108Z0R	Transferase
Ththe16_1884	ENOG41062IR	nudix hydrolase
Ththe16_1886	ENOG4105CI3	gtp-binding protein typa
Ththe16_1888	ENOG4105D1H	recombination factor protein RarA
Ththe16_1890	ENOG4105DRS	transport system, permease
Ththe16_1891	ENOG4105CJ1	ABC, transporter
Ththe16_1894	ENOG4105C7S	Dehydrogenase
Ththe16_1895	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
Ththe16_1896	ENOG4105ZU5	s-layer protein
Ththe16_1897	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
Ththe16_1898	ENOG4105CWE	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Ththe16_1902	ENOG4105C4K	Nad synthetase
Ththe16_1904	ENOG4107RFW	hydrolase family 57
Ththe16_1905	ENOG4107U4Q	acetylglutamate kinase
Ththe16_1906	ENOG4105C0N	N-acetylglutamate semialdehyde dehydrogenase
Ththe16_1907	ENOG4105D9I	Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)
Ththe16_1908	ENOG4106928	lysine biosynthesis protein LysW
Ththe16_1910	ENOG4108S93	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Ththe16_1911	ENOG4105CQI	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)
Ththe16_1914	ENOG4108JZA	Homocitrate synthase
Ththe16_1915	ENOG4105CR3	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)
Ththe16_1916	ENOG4105C1G	acyl-Coa dehydrogenase
Ththe16_1917	ENOG4108UMA	3-octaprenyl-4-hydroxybenzoate carboxy-lyase
Ththe16_1919	ENOG4105C3M	thioredoxin reductase
Ththe16_1923	ENOG4108IUW	ABC transporter
Ththe16_1928	ENOG4105CGT	Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)
Ththe16_1929	ENOG4105C2S	Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)
Ththe16_1931	ENOG4105DJ5	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)
Ththe16_1932	ENOG4107EUI	c reductase, iron-sulfur
Ththe16_1937	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
Ththe16_1938	ENOG4105C1G	acyl-Coa dehydrogenase
Ththe16_1940	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
Ththe16_1944	ENOG41082VC	UPF0145 protein
Ththe16_1946	ENOG4105DXN	mazG family
Ththe16_1948	ENOG4107R7Y	intracellular protease Pfpi family
Ththe16_1949	ENOG4107RRU	Involved in both the arginine and lysine biosynthetic pathways (By similarity)
Ththe16_1951	ENOG4105C6E	dna polymerase iii
Ththe16_1952	ENOG4105VPX	protein, conserved in bacteria
Ththe16_1954	ENOG4105DI2	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein
Ththe16_1955	ENOG4105DQU	oxidoreductase, subunit beta
Ththe16_1956	ENOG4105MWK	D-amino acid dehydrogenase, small subunit
Ththe16_1957	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
Ththe16_1958	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
Ththe16_1960	ENOG4105CTQ	phosphohexokinase
Ththe16_1963	ENOG4105F0N	pyrophosphate phospho-hydrolase
Ththe16_1966	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
Ththe16_1967	ENOG4105FA0	parb-like partition protein
Ththe16_1968	ENOG4107SKI	cobyrinic Acid a,c-diamide synthase
Ththe16_1969	ENOG4107YBR	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
Ththe16_1970	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
Ththe16_1973	ENOG4105D06	uba thif-type nad fad binding protein
Ththe16_1974	ENOG4107QI1	Mate efflux family protein
Ththe16_1976	ENOG4105D5G	Transposase
Ththe16_1982	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
Ththe16_1985	ENOG4105D5G	Transposase
Ththe16_1987	ENOG4108IJ6	ABC transporter
Ththe16_1988	ENOG4105NAU	thioesterase Superfamily protein
Ththe16_1990	ENOG4105BZH	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)
Ththe16_1991	ENOG4108UUM	single-stranded DNA-binding protein
Ththe16_2012	ENOG4105ZU5	s-layer protein
Ththe16_2013	ENOG4105CD2	stage iii sporulation protein aa
Ththe16_2028	ENOG4106FRU	abrb family transcriptional regulator
Ththe16_2036	ENOG4105DS7	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)
Ththe16_2047	ENOG4105MVE	transcriptional regulator
Ththe16_2049	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
Ththe16_2051	ENOG4105D7K	pfkb domain protein
Ththe16_2053	ENOG4108HRG	Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity)
Ththe16_2054	ENOG4105C2J	ABC transporter
Ththe16_2055	ENOG41062B0	ABC transporter, permease
Ththe16_2056	ENOG4105C26	Dehydrogenase
Ththe16_2062	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
Ththe16_2063	ENOG4105FA0	parb-like partition protein
Ththe16_2064	ENOG4105BZK	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity)
Ththe16_2065	ENOG4107R3N	Filamentation induced by cAMP protein fic
Ththe16_2075	ENOG4105DTT	CRISPR-associated helicase, cas3
Ththe16_2078	ENOG4107R2I	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation
Ththe16_2092	ENOG41066GP	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Ththe16_2107	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
Ththe16_2114	ENOG4106EQQ	Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity)
Ththe16_2137	ENOG4105FA0	parb-like partition protein
Ththe16_2143	ENOG4106IPI	cyclase, family
Ththe16_2145	ENOG4105EFP	binding-protein-dependent transport systems inner membrane Component
Ththe16_2146	ENOG4107UWC	ABC, transporter
Ththe16_2149	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Ththe16_2151	ENOG4105E7W	lamb ycsf family protein
Ththe16_2154	ENOG4105FB9	CRISPR-associated protein
Ththe16_2158	ENOG4105DYN	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)
Ththe16_2159	ENOG4105KCF	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)
Ththe16_2161	ENOG4107YVC	modification (methylase)
Ththe16_2165	ENOG4105ETE	Transcriptional regulator (LacI family
Ththe16_2167	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
Ththe16_2168	ENOG4105DRS	transport system, permease
Ththe16_2171	ENOG4105C26	Dehydrogenase
Ththe16_2172	ENOG4108JPX	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
Ththe16_2174	ENOG4107PP3	Acetylornithine deacetylase
Ththe16_2175	ENOG4105DEF	Extracellular solute-binding protein, family 5
Ththe16_2177	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Ththe16_2182	ENOG4106K5Q	Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)
Ththe16_2185	ENOG4105C6V	Glycerol-3-phosphate dehydrogenase
Ththe16_2188	ENOG4105EX2	Binding-protein-dependent transport systems, inner membrane component
Ththe16_2189	ENOG4105E4X	binding-protein-dependent transport systems inner membrane Component
Ththe16_2192	ENOG4108VXP	Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity)
Ththe16_2193	ENOG4106KNT	transcriptional regulator
Ththe16_2194	ENOG4108QXE	glycerophosphoryl diester phosphodiesterase
Ththe16_2196	ENOG4105C2C	drug resistance transporter, Bcr CflA
Ththe16_2198	ENOG4105VG1	fes assembly suf system protein
Ththe16_2207	ENOG4108IUE	nitrate reductase beta subunit
Ththe16_2209	ENOG41067HZ	cytochrome C, class I
Ththe16_2211	ENOG4105DS0	Transcriptional regulator, Crp Fnr family
Ththe16_2212	ENOG4108Z4U	Ferredoxin
Ththe16_2226	ENOG41067HZ	cytochrome C, class I
Ththe16_2227	ENOG4105CM1	Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)
Ththe16_2228	ENOG4105F64	nitrite reductase
Ththe16_2231	ENOG4108VKQ	nitriC oxide reductase
Ththe16_2242	ENOG41089N3	Inherit from COG: cobyrinic Acid a,c-diamide synthase
Ththe16_2243	ENOG4105FA0	parb-like partition protein
Ththe16_2257	ENOG4105N2W	Transcriptional regulator
Ththe16_2258	ENOG4108JE9	extracellular solute-binding protein family 1
Ththe16_2260	ENOG4105DRS	transport system, permease
Ththe16_2262	ENOG4107R49	K07407 alpha-galactosidase EC 3.2.1.22
Ththe16_2263	ENOG4105F0Z	galactose-1-phosphate uridylyltransferase
Ththe16_2266	ENOG4106UJV	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)
Ththe16_2270	ENOG41076QQ	Glycosyl transferase, family 2
Ththe16_2277	ENOG4105FE1	phytoene synthase
Ththe16_2279	ENOG41090K0	Transcriptional regulator, Crp Fnr family
Ththe16_2281	ENOG4107WCI	zn-dependent hydrolase of the beta-lactamase fold-like protein
Ththe16_2284	ENOG4105HS6	binding-protein-dependent transport systems inner membrane Component
Ththe16_2287	ENOG4105CHR	reductase
Ththe16_2290	ENOG4105I7Z	Short-chain dehydrogenase reductase Sdr
Ththe16_2291	ENOG4105CG6	trap dicarboxylate transporter dctm subunit
Ththe16_2293	ENOG4105GQU	Trap dicarboxylate transporter, dctp subunit
Ththe16_2294	ENOG4107HP6	Transcriptional regulator
Ththe16_2295	ENOG4108UHU	Aldolase
Ththe16_2301	ENOG4105CE4	GlcNAc 6-P deacetylase
Ththe16_2302	ENOG4105G6Z	alkaline phosphatase
Ththe16_2303	ENOG4105CAA	catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Ththe16_2306	ENOG4105CIH	Imidazole acetol-phosphate transaminase
Ththe16_2309	ENOG4105DH2	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)
Ththe16_2310	ENOG4105E7Q	Cob(II)yrinic acid a,c-diamide reductase
Ththe16_2311	ENOG4105CB8	Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)
Ththe16_2313	ENOG4105DAT	cobalamin (vitamin b12) biosynthesis cbix protein
Ththe16_2314	ENOG4108P62	biosynthesis protein (CbiG)
Ththe16_2315	ENOG4105E4R	Precorrin-3B C17-methyltransferase
Ththe16_2316	ENOG4105CIA	precorrin-4 C(11)-methyltransferase
Ththe16_2318	ENOG4105CX4	Precorrin-6y C5,15-methyltransferase
Ththe16_2319	ENOG41081F0	Precorrin-8x methylmutase
Ththe16_2320	ENOG4105EE8	May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)
Ththe16_2321	ENOG4105D9G	High-affinity
Ththe16_2322	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
Ththe16_2325	ENOG4107XPA	Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)
Ththe16_2327	ENOG41068B1	Cob-I-yrinic acid a,c-diamide adenosyltransferase
Ththe16_2328	ENOG4105C0Y	Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)
Ththe16_2344	ENOG4105DEF	Extracellular solute-binding protein, family 5
Ththe16_2345	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
Ththe16_2346	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
Ththe16_2348	ENOG4108JQ7	(ABC) transporter
Ththe16_2354	ENOG4105WRB	Hydrogenase assembly chaperone hypC hupF
Ththe16_2356	ENOG4105CQS	hydrogenase expression formation protein HypD
Ththe16_2357	ENOG4105C45	hydrogenase expression formation protein (HypE)
Ththe16_2358	ENOG4105F55	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity)
Ththe16_2361	ENOG4107YEI	lmbE family
Ththe16_2362	ENOG4105K6V	RNA polymerase
Ththe16_2366	ENOG4105D9G	High-affinity
Ththe16_2369	ENOG4105WMM	Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity)
Ththe16_2379	ENOG4105CTD	carboxy-peptidase
Ththe16_2389	ENOG4105RX7	peptidase S8 and S53, subtilisin, kexin, sedolisin
Ththe16_R0039	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation