locus-tag	class	description
Ththe16_0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Ththe16_0002	COG0592	DNA-directed DNA polymerase activity
Ththe16_0003	COG0148	phosphopyruvate hydratase activity
Ththe16_0004	COG0469	pyruvate kinase activity
Ththe16_0006	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ththe16_0007	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ththe16_0009	COG1842	Phage shock protein A
Ththe16_0012	COG0406	alpha-ribazole phosphatase activity
Ththe16_0013	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Ththe16_0014	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ththe16_0017	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
Ththe16_0019	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Ththe16_0020	COG1278	Cold shock
Ththe16_0021	COG1653	transport
Ththe16_0024	COG0033	Phosphoglucomutase
Ththe16_0026	COG2814	Major facilitator Superfamily
Ththe16_0028	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Ththe16_0028	COG0517	IMP dehydrogenase activity
Ththe16_0029	COG1950	PFAM Membrane protein of
Ththe16_0030	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ththe16_0032	COG0181	hydroxymethylbilane synthase activity
Ththe16_0034	COG0285	dihydrofolate synthase activity
Ththe16_0035	COG0436	Aminotransferase
Ththe16_0036	COG0521	Mo-molybdopterin cofactor biosynthetic process
Ththe16_0041	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Ththe16_0042	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Ththe16_0043	COG1993	acr, cog1993
Ththe16_0044	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Ththe16_0046	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Ththe16_0048	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Ththe16_0049	COG1335	isochorismatase
Ththe16_0050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Ththe16_0053	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Ththe16_0054	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
Ththe16_0056	COG0242	peptide deformylase activity
Ththe16_0057	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Ththe16_0058	COG1660	Displays ATPase and GTPase activities
Ththe16_0059	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Ththe16_0068	COG1845	cytochrome c oxidase, subunit III
Ththe16_0068	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ththe16_0070	COG1612	heme a metabolic process
Ththe16_0070	COG0109	protoheme IX farnesyltransferase activity
Ththe16_0073	COG0343	queuine tRNA-ribosyltransferase activity
Ththe16_0074	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Ththe16_0075	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Ththe16_0086	COG1940	carbohydrate kinase activity
Ththe16_0088	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ththe16_0090	COG0589	response to stress
Ththe16_0091	COG1611	Belongs to the LOG family
Ththe16_0093	COG1011	Hydrolase
Ththe16_0094	COG0632	four-way junction helicase activity
Ththe16_0095	COG1024	Enoyl-CoA hydratase
Ththe16_0097	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ththe16_0099	COG0137	argininosuccinate synthase activity
Ththe16_0100	COG0165	Argininosuccinate lyase
Ththe16_0101	COG0165	Argininosuccinate lyase
Ththe16_0101	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Ththe16_0104	COG0505	Belongs to the CarA family
Ththe16_0105	COG2759	Belongs to the formate--tetrahydrofolate ligase family
Ththe16_0107	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Ththe16_0108	COG0166	Belongs to the GPI family
Ththe16_0110	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ththe16_0112	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ththe16_0113	COG0459	protein refolding
Ththe16_0114	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Ththe16_0115	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
Ththe16_0118	COG1388	LysM domain
Ththe16_0118	COG0791	NLP P60 protein
Ththe16_0120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ththe16_0122	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Ththe16_0123	COG0581	inorganic phosphate transmembrane transporter activity
Ththe16_0124	COG0573	inorganic phosphate transmembrane transporter activity
Ththe16_0125	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ththe16_0126	COG0482	sulfurtransferase activity
Ththe16_0128	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ththe16_0129	COG0735	belongs to the Fur family
Ththe16_0132	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Ththe16_0133	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ththe16_0134	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Ththe16_0135	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ththe16_0136	COG0250	Participates in transcription elongation, termination and antitermination
Ththe16_0137	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Ththe16_0138	COG0081	regulation of translation
Ththe16_0139	COG0360	Binds together with S18 to 16S ribosomal RNA
Ththe16_0140	COG0629	single-stranded DNA binding
Ththe16_0141	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
Ththe16_0142	COG0359	binds to the 23S rRNA
Ththe16_0144	COG0300	oxidoreductase activity
Ththe16_0145	COG0321	lipoyl(octanoyl) transferase activity
Ththe16_0146	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Ththe16_0157	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ththe16_0160	COG1598	PFAM Uncharacterised protein family UPF0150
Ththe16_0161	COG0022	dehydrogenase e1 component
Ththe16_0162	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Ththe16_0163	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Ththe16_0168	COG2226	methyltransferase
Ththe16_0169	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Ththe16_0172	COG1187	pseudouridine synthase activity
Ththe16_0174	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Ththe16_0177	COG1461	Dihydroxyacetone kinase
Ththe16_0180	COG4591	ABC-type transport system involved in lipoprotein release permease component
Ththe16_0181	COG0222	ribosome binding
Ththe16_0182	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Ththe16_0183	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Ththe16_0184	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Ththe16_0185	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Ththe16_0187	COG0697	spore germination
Ththe16_0189	COG3177	Filamentation induced by cAMP protein fic
Ththe16_0191	COG0243	molybdopterin cofactor binding
Ththe16_0192	COG2272	Belongs to the type-B carboxylesterase lipase family
Ththe16_0193	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Ththe16_0195	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Ththe16_0201	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Ththe16_0203	COG0105	UTP biosynthetic process
Ththe16_0204	COG0631	protein serine/threonine phosphatase activity
Ththe16_0206	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Ththe16_0212	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Ththe16_0214	COG1278	Cold shock
Ththe16_0215	COG0484	heat shock protein binding
Ththe16_0216	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Ththe16_0217	COG1968	undecaprenyl-diphosphatase activity
Ththe16_0218	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Ththe16_0219	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Ththe16_0222	COG1309	transcriptional regulator
Ththe16_0223	COG4242	Belongs to the peptidase S51 family
Ththe16_0226	COG0802	atpase or kinase
Ththe16_0227	COG0539	negative regulation of cytoplasmic translation
Ththe16_0228	COG0495	leucyl-tRNA aminoacylation
Ththe16_0231	COG1902	pentaerythritol trinitrate reductase activity
Ththe16_0233	COG2414	aldehyde ferredoxin oxidoreductase
Ththe16_0238	COG1187	pseudouridine synthase activity
Ththe16_0240	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Ththe16_0241	COG0745	RESPONSE REGULATOR receiver
Ththe16_0242	COG4191	Histidine kinase
Ththe16_0243	COG0704	Plays a role in the regulation of phosphate uptake
Ththe16_0246	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Ththe16_0248	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ththe16_0248	COG0515	serine threonine protein kinase
Ththe16_0249	COG0251	oxidation-reduction process
Ththe16_0252	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Ththe16_0253	COG1028	Short-chain dehydrogenase reductase Sdr
Ththe16_0256	COG0717	Belongs to the dCTP deaminase family
Ththe16_0257	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Ththe16_0258	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
Ththe16_0259	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Ththe16_0260	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ththe16_0262	COG0583	DNA-binding transcription factor activity
Ththe16_0263	COG3546	catalase activity
Ththe16_0264	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ththe16_0264	COG0758	DNA mediated transformation
Ththe16_0265	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Ththe16_0267	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
Ththe16_0269	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
Ththe16_0270	COG0442	prolyl-tRNA aminoacylation
Ththe16_0271	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Ththe16_0275	COG0303	'Molybdopterin
Ththe16_0276	COG0513	Belongs to the DEAD box helicase family
Ththe16_0279	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Ththe16_0282	COG2070	2-Nitropropane dioxygenase
Ththe16_0285	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ththe16_0286	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ththe16_0287	COG0018	arginyl-trna synthetase
Ththe16_0288	COG1007	ATP synthesis coupled electron transport
Ththe16_0289	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ththe16_0290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ththe16_0291	COG0713	ATP synthesis coupled electron transport
Ththe16_0292	COG0839	Belongs to the complex I subunit 6 family
Ththe16_0293	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ththe16_0294	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Ththe16_0295	COG1034	ATP synthesis coupled electron transport
Ththe16_0296	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
Ththe16_0297	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Ththe16_0298	COG0649	NAD binding
Ththe16_0299	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ththe16_0300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ththe16_0301	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ththe16_0302	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Ththe16_0304	COG4712	double-strand break repair protein
Ththe16_0307	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Ththe16_0310	COG0135	phosphoribosylanthranilate isomerase activity
Ththe16_0311	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Ththe16_0311	COG1372	Participates in initiation and elongation during chromosome replication
Ththe16_0312	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ththe16_0314	COG2720	vancomycin resistance protein
Ththe16_0321	COG0277	FAD linked oxidase domain protein
Ththe16_0323	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Ththe16_0325	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ththe16_0328	COG0314	molybdopterin synthase activity
Ththe16_0329	COG1420	regulation of RNA biosynthetic process
Ththe16_0330	COG0347	Belongs to the P(II) protein family
Ththe16_0331	COG0004	ammonium transporteR
Ththe16_0333	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Ththe16_0335	COG0123	including yeast histone deacetylase and acetoin utilization protein
Ththe16_0338	COG1597	lipid kinase activity
Ththe16_0343	COG0569	domain protein
Ththe16_0343	COG0475	glutathione-regulated potassium exporter activity
Ththe16_0345	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Ththe16_0349	COG3335	DDE superfamily endonuclease
Ththe16_0350	COG0667	Aldo Keto reductase
Ththe16_0354	COG3706	GGDEF domain
Ththe16_0356	COG1067	ATP-dependent peptidase activity
Ththe16_0357	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Ththe16_0359	COG0745	RESPONSE REGULATOR receiver
Ththe16_0360	COG2105	PFAM AIG2 family protein
Ththe16_0361	COG0297	glycogen (starch) synthase activity
Ththe16_0363	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ththe16_0364	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Ththe16_0367	COG0142	geranyltranstransferase activity
Ththe16_0369	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ththe16_0370	COG1028	Short-chain dehydrogenase reductase Sdr
Ththe16_0371	COG0492	ferredoxin-NADP+ reductase activity
Ththe16_0372	COG0515	serine threonine protein kinase
Ththe16_0372	COG2815	serine threonine protein kinase
Ththe16_0373	COG0792	nuclease activity
Ththe16_0374	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Ththe16_0377	COG1175	transmembrane transport
Ththe16_0378	COG0395	ABC-type sugar transport system, permease component
Ththe16_0384	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Ththe16_0385	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Ththe16_0386	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ththe16_0387	COG0805	protein transport
Ththe16_0388	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Ththe16_0388	COG1605	Chorismate mutase
Ththe16_0399	COG1063	alcohol dehydrogenase
Ththe16_0405	COG2255	four-way junction helicase activity
Ththe16_0406	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Ththe16_0407	COG0564	pseudouridine synthase activity
Ththe16_0410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ththe16_0411	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Ththe16_0412	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ththe16_0413	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ththe16_0415	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ththe16_0416	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ththe16_0417	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Ththe16_0425	COG0778	Nitroreductase
Ththe16_0428	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ththe16_0429	COG0131	Imidazoleglycerol-phosphate dehydratase
Ththe16_0430	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Ththe16_0431	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ththe16_0432	COG0516	GMP reductase activity
Ththe16_0432	COG0517	IMP dehydrogenase activity
Ththe16_0435	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
Ththe16_0439	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ththe16_0442	COG2890	protein-(glutamine-N5) methyltransferase activity
Ththe16_0444	COG0706	membrane insertase activity
Ththe16_0445	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Ththe16_0446	COG0594	ribonuclease P activity
Ththe16_0448	COG1022	Amp-dependent synthetase and ligase
Ththe16_0449	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ththe16_0453	COG1121	(ABC) transporter
Ththe16_0454	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ththe16_0455	COG1959	2 iron, 2 sulfur cluster binding
Ththe16_0456	COG1104	cysteine desulfurase activity
Ththe16_0457	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Ththe16_0458	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Ththe16_0459	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ththe16_0459	COG1213	nucleotidyl transferase
Ththe16_0461	COG1028	Short-chain dehydrogenase reductase Sdr
Ththe16_0465	COG0492	ferredoxin-NADP+ reductase activity
Ththe16_0467	COG0747	negative chemotaxis
Ththe16_0468	COG0601	transmembrane transport
Ththe16_0469	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ththe16_0472	COG0517	IMP dehydrogenase activity
Ththe16_0473	COG0123	including yeast histone deacetylase and acetoin utilization protein
Ththe16_0474	COG2104	thiamine diphosphate biosynthetic process
Ththe16_0475	COG0037	tRNA processing
Ththe16_0478	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Ththe16_0480	COG4176	ABC-type proline glycine betaine transport system permease component
Ththe16_0481	COG3448	diguanylate cyclase activity
Ththe16_0481	COG4175	Glycine betaine
Ththe16_0482	COG0366	Alpha amylase catalytic
Ththe16_0483	COG2226	methyltransferase
Ththe16_0484	COG2226	methyltransferase
Ththe16_0486	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Ththe16_0487	COG3744	PilT protein domain protein
Ththe16_0489	COG0460	homoserine dehydrogenase
Ththe16_0491	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Ththe16_0497	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ththe16_0502	COG0247	lactate metabolic process
Ththe16_0504	COG0277	FAD linked oxidase domain protein
Ththe16_0505	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Ththe16_0506	COG1414	Transcriptional regulator
Ththe16_0507	COG0789	Transcriptional regulator
Ththe16_0508	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ththe16_0509	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ththe16_0510	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Ththe16_0517	COG0861	Integral membrane protein TerC family
Ththe16_0518	COG2151	metal-sulfur cluster biosynthetic enzyme
Ththe16_0519	COG0281	malic enzyme
Ththe16_0522	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Ththe16_0523	COG0509	glycine decarboxylation via glycine cleavage system
Ththe16_0524	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ththe16_0525	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ththe16_0526	COG0196	riboflavin kinase activity
Ththe16_0527	COG1051	belongs to the nudix hydrolase family
Ththe16_0531	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ththe16_0532	COG2813	Specifically methylates the guanine in position
Ththe16_0533	COG0527	aspartate kinase activity
Ththe16_0535	COG0039	L-malate dehydrogenase activity
Ththe16_0539	COG4956	integral membrane protein (PIN domain superfamily)
Ththe16_0540	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Ththe16_0541	COG0542	response to heat
Ththe16_0542	COG0423	glycine-tRNA ligase activity
Ththe16_0545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Ththe16_0549	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ththe16_0549	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ththe16_0551	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
Ththe16_0552	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Ththe16_0553	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Ththe16_0555	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ththe16_0556	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Ththe16_0557	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Ththe16_0558	COG0114	fumarate hydratase activity
Ththe16_0559	COG0183	Belongs to the thiolase family
Ththe16_0561	COG3335	DDE superfamily endonuclease
Ththe16_0564	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Ththe16_0565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Ththe16_0568	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Ththe16_0569	COG1254	Belongs to the acylphosphatase family
Ththe16_0571	COG1063	alcohol dehydrogenase
Ththe16_0572	COG2133	pyrroloquinoline quinone binding
Ththe16_0574	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Ththe16_0575	COG0154	amidase activity
Ththe16_0580	COG0572	uridine kinase
Ththe16_0581	COG3842	ATPase activity
Ththe16_0584	COG4475	Protein of unknown function (DUF436)
Ththe16_0596	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Ththe16_0597	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Ththe16_0598	COG0803	Belongs to the bacterial solute-binding protein 9 family
Ththe16_0602	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ththe16_0603	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Ththe16_0608	COG0318	PFAM AMP-dependent synthetase and ligase
Ththe16_0609	COG2030	dehydratase
Ththe16_0609	COG1012	belongs to the aldehyde dehydrogenase family
Ththe16_0610	COG1960	acyl-CoA dehydrogenase activity
Ththe16_0613	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Ththe16_0615	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
Ththe16_0617	COG3870	Protein conserved in bacteria
Ththe16_0618	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Ththe16_0620	COG0544	peptidyl-prolyl cis-trans isomerase activity
Ththe16_0621	COG0740	serine-type endopeptidase activity
Ththe16_0622	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Ththe16_0623	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Ththe16_0624	COG0646	methionine synthase
Ththe16_0624	COG1410	methionine synthase
Ththe16_0627	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ththe16_0630	COG1692	metallophosphoesterase
Ththe16_0631	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Ththe16_0632	COG1970	mechanosensitive ion channel activity
Ththe16_0635	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Ththe16_0636	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Ththe16_0645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ththe16_0646	COG0438	transferase activity, transferring glycosyl groups
Ththe16_0649	COG1215	transferase activity, transferring glycosyl groups
Ththe16_0650	COG1215	transferase activity, transferring glycosyl groups
Ththe16_0653	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ththe16_0657	COG0489	protein tyrosine kinase activity
Ththe16_0659	COG2264	protein methyltransferase activity
Ththe16_0660	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Ththe16_0668	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ththe16_0669	COG2046	Belongs to the sulfate adenylyltransferase family
Ththe16_0670	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ththe16_0670	COG1648	precorrin-2 dehydrogenase activity
Ththe16_0671	COG0730	response to heat
Ththe16_0672	COG0175	sulfate reduction
Ththe16_0673	COG1648	precorrin-2 dehydrogenase activity
Ththe16_0673	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ththe16_0674	COG1587	Uroporphyrinogen-III synthase
Ththe16_0675	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Ththe16_0676	COG0352	thiamine-phosphate diphosphorylase activity
Ththe16_0677	COG2104	thiamine diphosphate biosynthetic process
Ththe16_0678	COG2022	thiamine diphosphate biosynthetic process
Ththe16_0679	COG2022	thiamine diphosphate biosynthetic process
Ththe16_0679	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ththe16_0680	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
Ththe16_0681	COG0477	Major facilitator Superfamily
Ththe16_0682	COG0351	phosphomethylpyrimidine kinase
Ththe16_0682	COG0352	thiamine-phosphate diphosphorylase activity
Ththe16_0690	COG1940	carbohydrate kinase activity
Ththe16_0691	COG0183	Belongs to the thiolase family
Ththe16_0694	COG1028	Short-chain dehydrogenase reductase Sdr
Ththe16_0695	COG0410	ABC transporter
Ththe16_0698	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ththe16_0700	COG2030	dehydratase
Ththe16_0702	COG0596	Alpha beta hydrolase
Ththe16_0703	COG0318	PFAM AMP-dependent synthetase and ligase
Ththe16_0704	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ththe16_0706	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ththe16_0706	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ththe16_0708	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ththe16_0710	COG0195	Participates in both transcription termination and antitermination
Ththe16_0711	COG0779	Required for maturation of 30S ribosomal subunits
Ththe16_0713	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
Ththe16_0714	COG0640	Transcriptional regulator
Ththe16_0715	COG2217	Heavy metal translocating P-type atpase
Ththe16_0717	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
Ththe16_0719	COG0017	Asparaginyl-tRNA synthetase
Ththe16_0720	COG0561	phosphatase activity
Ththe16_0721	COG0384	phenazine biosynthesis protein PhzF
Ththe16_0722	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ththe16_0723	COG0124	histidyl-tRNA synthetase
Ththe16_0726	COG3842	ATPase activity
Ththe16_0729	COG1573	uracil-dna glycosylase
Ththe16_0733	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
Ththe16_0736	COG1316	TRANSCRIPTIONal
Ththe16_0737	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Ththe16_0746	COG0295	cytidine deaminase activity
Ththe16_0748	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ththe16_0750	COG1760	l-serine dehydratase
Ththe16_0752	COG0481	GTPase activity
Ththe16_0754	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ththe16_0757	COG1028	Short-chain dehydrogenase reductase Sdr
Ththe16_0762	COG0405	Gamma-glutamyltransferase
Ththe16_0763	COG1073	alpha beta
Ththe16_0766	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Ththe16_0767	COG2873	o-acetylhomoserine
Ththe16_0770	COG1063	alcohol dehydrogenase
Ththe16_0772	COG3191	aminopeptidase activity
Ththe16_0773	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ththe16_0774	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ththe16_0775	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ththe16_0776	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ththe16_0776	COG1116	anion transmembrane transporter activity
Ththe16_0777	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ththe16_0779	COG0167	dihydroorotate dehydrogenase activity
Ththe16_0787	COG0730	response to heat
Ththe16_0788	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Ththe16_0791	COG0312	modulator of DNA gyrase
Ththe16_0792	COG0312	modulator of DNA gyrase
Ththe16_0794	COG1960	acyl-CoA dehydrogenase activity
Ththe16_0795	COG0456	acetyltransferase
Ththe16_0797	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Ththe16_0798	COG0009	L-threonylcarbamoyladenylate synthase
Ththe16_0802	COG0277	FAD linked oxidase domain protein
Ththe16_0804	COG0287	Prephenate dehydrogenase
Ththe16_0805	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
Ththe16_0806	COG2514	catechol 2,3-dioxygenase activity
Ththe16_0807	COG2353	YceI-like domain
Ththe16_0808	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Ththe16_0809	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Ththe16_0813	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ththe16_0814	COG0179	Fumarylacetoacetate (FAA) hydrolase
Ththe16_0816	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Ththe16_0817	COG0151	Belongs to the GarS family
Ththe16_0818	COG2176	DNA-directed DNA polymerase activity
Ththe16_0818	COG5002	protein histidine kinase activity
Ththe16_0824	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Ththe16_0826	COG0217	transcriptional regulatory protein
Ththe16_0827	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ththe16_0827	COG4651	solute:proton antiporter activity
Ththe16_0828	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Ththe16_0829	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Ththe16_0830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Ththe16_0831	COG1674	ftsk spoiiie
Ththe16_0834	COG0517	IMP dehydrogenase activity
Ththe16_0836	COG0617	tRNA 3'-terminal CCA addition
Ththe16_0838	COG1994	Peptidase M50
Ththe16_0839	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Ththe16_0841	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ththe16_0844	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ththe16_0846	COG2719	SpoVR family
Ththe16_0847	COG2718	Belongs to the UPF0229 family
Ththe16_0848	COG2766	serine protein kinase
Ththe16_0853	COG2137	regulation of response to DNA damage stimulus
Ththe16_0855	COG2359	stage V sporulation protein S
Ththe16_0856	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ththe16_0857	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Ththe16_0859	COG0463	Glycosyl transferase, family 2
Ththe16_0860	COG0750	zinc metalloprotease
Ththe16_0861	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Ththe16_0862	COG4589	Belongs to the CDS family
Ththe16_0863	COG0233	cytoplasmic translational termination
Ththe16_0864	COG0528	UMP kinase activity
Ththe16_0865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Ththe16_0866	COG0052	Belongs to the universal ribosomal protein uS2 family
Ththe16_0868	COG0494	nUDIX hydrolase
Ththe16_0872	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Ththe16_0874	COG0402	S-adenosylhomocysteine deaminase activity
Ththe16_0876	COG4948	Mandelate Racemase Muconate Lactonizing
Ththe16_0877	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Ththe16_0878	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Ththe16_0879	COG1811	Na channel or pump
Ththe16_0880	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Ththe16_0880	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ththe16_0883	COG1215	transferase activity, transferring glycosyl groups
Ththe16_0885	COG1215	transferase activity, transferring glycosyl groups
Ththe16_0887	COG0438	transferase activity, transferring glycosyl groups
Ththe16_0888	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Ththe16_0891	COG1024	Enoyl-CoA hydratase
Ththe16_0891	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ththe16_0892	COG0183	Belongs to the thiolase family
Ththe16_0893	COG1960	acyl-CoA dehydrogenase activity
Ththe16_0894	COG0215	cysteine-tRNA ligase activity
Ththe16_0895	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Ththe16_0898	COG2873	o-acetylhomoserine
Ththe16_0902	COG1196	nuclear chromosome segregation
Ththe16_0905	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Ththe16_0906	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ththe16_0907	COG1268	BioY protein
Ththe16_0909	COG0126	phosphoglycerate kinase activity
Ththe16_0910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Ththe16_0911	COG0824	Thioesterase
Ththe16_0913	COG0557	exoribonuclease II activity
Ththe16_0914	COG1355	regulation of microtubule-based process
Ththe16_0915	COG0617	tRNA 3'-terminal CCA addition
Ththe16_0916	COG0237	dephospho-CoA kinase activity
Ththe16_0918	COG0742	ribosomal rna small subunit methyltransferase
Ththe16_0919	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Ththe16_0920	COG0138	bifunctional purine biosynthesis protein purh
Ththe16_0921	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ththe16_0923	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Ththe16_0930	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Ththe16_0938	COG0149	triose-phosphate isomerase activity
Ththe16_0939	COG3239	Fatty acid desaturase
Ththe16_0940	COG1490	D-aminoacyl-tRNA deacylase activity
Ththe16_0941	COG1307	EDD domain protein, DegV family
Ththe16_0942	COG1307	EDD domain protein, DegV family
Ththe16_0943	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ththe16_0944	COG1510	regulation of RNA biosynthetic process
Ththe16_0948	COG1136	(ABC) transporter
Ththe16_0951	COG3769	mannosylglycerate metabolic process
Ththe16_0953	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ththe16_0955	COG1012	belongs to the aldehyde dehydrogenase family
Ththe16_0956	COG2368	4-hydroxyphenylacetate
Ththe16_0957	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ththe16_0960	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ththe16_0961	COG0411	ABC transporter
Ththe16_0962	COG0410	ABC transporter
Ththe16_0963	COG2050	protein possibly involved in aromatic compounds catabolism
Ththe16_0964	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
Ththe16_0969	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Ththe16_0973	COG0438	transferase activity, transferring glycosyl groups
Ththe16_0975	COG0438	transferase activity, transferring glycosyl groups
Ththe16_0976	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Ththe16_0983	COG1085	galactose-1-phosphate uridylyltransferase
Ththe16_0986	COG1012	belongs to the aldehyde dehydrogenase family
Ththe16_0986	COG2030	dehydratase
Ththe16_0990	COG3396	Phenylacetate-CoA oxygenase
Ththe16_0991	COG1309	transcriptional regulator
Ththe16_0992	COG4974	Belongs to the 'phage' integrase family
Ththe16_0993	COG3842	ATPase activity
Ththe16_0998	COG1980	fructose-bisphosphate aldolase activity
Ththe16_0999	COG1733	regulation of RNA biosynthetic process
Ththe16_1000	COG2193	ferroxidase activity
Ththe16_1001	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Ththe16_1002	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Ththe16_1004	COG1331	Highly conserved protein containing a thioredoxin domain
Ththe16_1005	COG0183	Belongs to the thiolase family
Ththe16_1006	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Ththe16_1007	COG0477	Major facilitator Superfamily
Ththe16_1008	COG1846	Transcriptional regulator
Ththe16_1013	COG1012	belongs to the aldehyde dehydrogenase family
Ththe16_1016	COG0210	DNA helicase
Ththe16_1019	COG0745	RESPONSE REGULATOR receiver
Ththe16_1020	COG2205	protein histidine kinase activity
Ththe16_1023	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ththe16_1024	COG1136	(ABC) transporter
Ththe16_1025	COG0577	efflux transmembrane transporter activity
Ththe16_1025	COG1136	(ABC) transporter
Ththe16_1039	COG0582	viral genome integration into host DNA
Ththe16_1040	COG2897	thiosulfate sulfurtransferase activity
Ththe16_1041	COG1760	l-serine dehydratase
Ththe16_1042	COG2197	response regulator
Ththe16_1043	COG0335	large ribosomal subunit rRNA binding
Ththe16_1044	COG0336	Belongs to the RNA methyltransferase TrmD family
Ththe16_1045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Ththe16_1046	COG1837	Belongs to the UPF0109 family
Ththe16_1047	COG0228	four-way junction DNA binding
Ththe16_1050	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Ththe16_1052	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Ththe16_1053	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Ththe16_1054	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ththe16_1056	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Ththe16_1057	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Ththe16_1058	COG1702	phosphate starvation-inducible protein PhoH
Ththe16_1060	COG4864	UPF0365 protein
Ththe16_1062	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Ththe16_1066	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ththe16_1066	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Ththe16_1067	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ththe16_1069	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Ththe16_1071	COG2239	Acts as a magnesium transporter
Ththe16_1072	COG2304	oxidoreductase activity
Ththe16_1073	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ththe16_1073	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ththe16_1075	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ththe16_1075	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ththe16_1076	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Ththe16_1077	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Ththe16_1078	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
Ththe16_1079	COG0006	proline dipeptidase activity
Ththe16_1081	COG0739	heme binding
Ththe16_1083	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Ththe16_1084	COG0254	rRNA binding
Ththe16_1085	COG2001	Belongs to the MraZ family
Ththe16_1086	COG0275	rRNA processing
Ththe16_1088	COG0768	penicillin binding
Ththe16_1089	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Ththe16_1091	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ththe16_1092	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Ththe16_1093	COG0772	Belongs to the SEDS family
Ththe16_1094	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
Ththe16_1095	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ththe16_1096	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Ththe16_1100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Ththe16_1102	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
Ththe16_1104	COG0159	tryptophan synthase activity
Ththe16_1105	COG0133	tryptophan synthase activity
Ththe16_1106	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
Ththe16_1107	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ththe16_1119	COG0438	transferase activity, transferring glycosyl groups
Ththe16_1120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ththe16_1122	COG0039	L-malate dehydrogenase activity
Ththe16_1123	COG2819	hydrolase of the alpha beta superfamily
Ththe16_1126	COG2181	nitrate reductase activity
Ththe16_1126	COG0247	lactate metabolic process
Ththe16_1128	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
Ththe16_1129	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Ththe16_1130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ththe16_1132	COG0439	Biotin carboxylase
Ththe16_1133	COG0511	ligase activity, forming carbon-carbon bonds
Ththe16_1134	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Ththe16_1137	COG1073	alpha beta
Ththe16_1138	COG0010	Belongs to the arginase family
Ththe16_1141	COG1100	Small GTP-binding protein
Ththe16_1143	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Ththe16_1144	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ththe16_1146	COG2814	Major facilitator Superfamily
Ththe16_1148	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
Ththe16_1149	COG1185	polyribonucleotide nucleotidyltransferase activity
Ththe16_1150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Ththe16_1151	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ththe16_1152	COG0745	RESPONSE REGULATOR receiver
Ththe16_1153	COG5002	protein histidine kinase activity
Ththe16_1154	COG1960	acyl-CoA dehydrogenase activity
Ththe16_1155	COG2086	electron transfer activity
Ththe16_1156	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Ththe16_1158	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Ththe16_1159	COG1573	uracil-dna glycosylase
Ththe16_1160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Ththe16_1160	COG1796	DNA polymerase
Ththe16_1164	COG2309	aminopeptidase activity
Ththe16_1168	COG2873	o-acetylhomoserine
Ththe16_1175	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ththe16_1176	COG3311	Transcriptional regulator
Ththe16_1178	COG0134	indole-3-glycerol-phosphate synthase activity
Ththe16_1179	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Ththe16_1181	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ththe16_1183	COG0525	valine-tRNA ligase activity
Ththe16_1184	COG0765	amino acid transport
Ththe16_1185	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ththe16_1187	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Ththe16_1188	COG0569	domain protein
Ththe16_1189	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ththe16_1190	COG1426	Protein conserved in bacteria
Ththe16_1194	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ththe16_1196	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Ththe16_1200	COG0012	GTP binding
Ththe16_1201	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Ththe16_1202	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ththe16_1203	COG0424	maF-like protein
Ththe16_1206	COG0768	penicillin binding
Ththe16_1207	COG0850	regulation of cytokinetic process
Ththe16_1212	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
Ththe16_1213	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Ththe16_1215	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Ththe16_1217	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ththe16_1219	COG1131	(ABC) transporter
Ththe16_1222	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ththe16_1225	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Ththe16_1226	COG0440	acetolactate synthase activity
Ththe16_1227	COG0028	Belongs to the TPP enzyme family
Ththe16_1228	COG0492	ferredoxin-NADP+ reductase activity
Ththe16_1237	COG4636	protein conserved in cyanobacteria
Ththe16_1242	COG0180	Tryptophanyl-tRNA synthetase
Ththe16_1244	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ththe16_1245	COG0066	3-isopropylmalate dehydratase activity
Ththe16_1246	COG0473	3-isopropylmalate dehydrogenase activity
Ththe16_1249	COG0300	oxidoreductase activity
Ththe16_1250	COG0129	dihydroxy-acid dehydratase activity
Ththe16_1252	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Ththe16_1253	COG1177	transmembrane transport
Ththe16_1254	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ththe16_1255	COG3842	ATPase activity
Ththe16_1256	COG0772	Belongs to the SEDS family
Ththe16_1257	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Ththe16_1258	COG2894	cell division
Ththe16_1259	COG1733	regulation of RNA biosynthetic process
Ththe16_1263	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ththe16_1264	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ththe16_1265	COG0653	protein targeting
Ththe16_1266	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Ththe16_1270	COG0393	Putative heavy-metal-binding
Ththe16_1271	COG1111	helicase
Ththe16_1271	COG1205	dead DEAH box helicase
Ththe16_1274	COG0358	DNA primase activity
Ththe16_1276	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ththe16_1277	COG0697	spore germination
Ththe16_1278	COG0612	Peptidase, M16
Ththe16_1279	COG0612	Peptidase, M16
Ththe16_1280	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ththe16_1283	COG1394	ATPase activity, coupled to movement of substances
Ththe16_1284	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
Ththe16_1285	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
Ththe16_1286	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
Ththe16_1287	COG1527	subunit (C
Ththe16_1288	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
Ththe16_1290	COG1269	ATP hydrolysis coupled proton transport
Ththe16_1295	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Ththe16_1297	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ththe16_1300	COG0419	ATPase involved in DNA repair
Ththe16_1301	COG0420	3'-5' exonuclease activity
Ththe16_1305	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Ththe16_1306	COG2884	Cell division ATP-binding protein ftsE
Ththe16_1307	COG0793	Belongs to the peptidase S41A family
Ththe16_1309	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ththe16_1309	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ththe16_1310	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Ththe16_1311	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ththe16_1315	COG1129	ABC transporter
Ththe16_1316	COG0746	molybdenum cofactor guanylyltransferase activity
Ththe16_1319	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ththe16_1323	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Ththe16_1324	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ththe16_1325	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Ththe16_1333	COG0788	formyltetrahydrofolate deformylase activity
Ththe16_1334	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Ththe16_1335	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Ththe16_1336	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Ththe16_1338	COG2010	Cytochrome c
Ththe16_1340	COG0737	Belongs to the 5'-nucleotidase family
Ththe16_1341	COG0174	glutamine synthetase
Ththe16_1343	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ththe16_1346	COG0410	ABC transporter
Ththe16_1347	COG0747	negative chemotaxis
Ththe16_1351	COG0285	dihydrofolate synthase activity
Ththe16_1352	COG1132	(ABC) transporter
Ththe16_1353	COG1132	(ABC) transporter
Ththe16_1354	COG0372	Belongs to the citrate synthase family
Ththe16_1355	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Ththe16_1356	COG1482	cell wall glycoprotein biosynthetic process
Ththe16_1358	COG1515	deoxyribonuclease V activity
Ththe16_1360	COG0776	regulation of translation
Ththe16_1363	COG2197	response regulator
Ththe16_1364	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ththe16_1365	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Ththe16_1366	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Ththe16_1367	COG1324	tolerance protein
Ththe16_1370	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ththe16_1374	COG2205	protein histidine kinase activity
Ththe16_1375	COG0247	lactate metabolic process
Ththe16_1376	COG1139	Iron-sulfur cluster binding protein
Ththe16_1377	COG1556	Lactate utilization protein
Ththe16_1378	COG0681	Belongs to the peptidase S26 family
Ththe16_1379	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ththe16_1380	COG2815	serine threonine protein kinase
Ththe16_1380	COG0515	serine threonine protein kinase
Ththe16_1381	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ththe16_1383	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
Ththe16_1388	COG0473	3-isopropylmalate dehydrogenase activity
Ththe16_1393	COG1450	Type ii and iii secretion system protein
Ththe16_1394	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Ththe16_1395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ththe16_1396	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Ththe16_1397	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ththe16_1397	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Ththe16_1398	COG0736	holo-[acyl-carrier-protein] synthase activity
Ththe16_1401	COG1160	GTP binding
Ththe16_1402	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Ththe16_1403	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ththe16_1403	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Ththe16_1404	COG0083	homoserine kinase activity
Ththe16_1407	COG0268	Binds directly to 16S ribosomal RNA
Ththe16_1409	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Ththe16_1410	COG0723	plastoquinol--plastocyanin reductase activity
Ththe16_1412	COG3088	subunit of a heme lyase
Ththe16_1412	COG4235	cytochrome complex assembly
Ththe16_1413	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Ththe16_1414	COG1138	Cytochrome C-type biogenesis protein
Ththe16_1415	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
Ththe16_1417	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Ththe16_1418	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Ththe16_1419	COG4133	protoheme IX ABC transporter activity
Ththe16_1420	COG0785	Cytochrome C biogenesis protein
Ththe16_1421	COG3258	Cytochrome c
Ththe16_1423	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ththe16_1426	COG3258	Cytochrome c
Ththe16_1427	COG2010	Cytochrome c
Ththe16_1428	COG0737	Belongs to the 5'-nucleotidase family
Ththe16_1429	COG2010	Cytochrome c
Ththe16_1430	COG3258	Cytochrome c
Ththe16_1434	COG2010	Cytochrome c
Ththe16_1435	COG3842	ATPase activity
Ththe16_1441	COG0318	PFAM AMP-dependent synthetase and ligase
Ththe16_1442	COG3360	Dodecin
Ththe16_1445	COG1024	Enoyl-CoA hydratase
Ththe16_1446	COG0813	purine-nucleoside phosphorylase activity
Ththe16_1447	COG1136	(ABC) transporter
Ththe16_1448	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ththe16_1449	COG2045	Belongs to the ComB family
Ththe16_1451	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ththe16_1453	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
Ththe16_1455	COG0107	imidazoleglycerol-phosphate synthase activity
Ththe16_1456	COG0140	phosphoribosyl-ATP diphosphatase activity
Ththe16_1456	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Ththe16_1457	COG1494	fructose-1,6-bisphosphatase
Ththe16_1458	COG0686	Belongs to the AlaDH PNT family
Ththe16_1459	COG0427	acetyl-CoA hydrolase
Ththe16_1460	COG0084	hydrolase, TatD family'
Ththe16_1461	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ththe16_1463	COG0017	Asparaginyl-tRNA synthetase
Ththe16_1465	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ththe16_1468	COG2009	succinate dehydrogenase
Ththe16_1469	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Ththe16_1475	COG0318	PFAM AMP-dependent synthetase and ligase
Ththe16_1476	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Ththe16_1477	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
Ththe16_1478	COG0504	CTP synthase activity
Ththe16_1480	COG0070	glutamate synthase
Ththe16_1480	COG0069	glutamate synthase activity
Ththe16_1480	COG0067	glutamate synthase
Ththe16_1482	COG0840	transmembrane signaling receptor activity
Ththe16_1483	COG0305	Participates in initiation and elongation during chromosome replication
Ththe16_1485	COG0475	glutathione-regulated potassium exporter activity
Ththe16_1486	COG2239	Acts as a magnesium transporter
Ththe16_1490	COG0490	domain, Protein
Ththe16_1494	COG3118	belongs to the thioredoxin family
Ththe16_1497	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ththe16_1506	COG0542	response to heat
Ththe16_1507	COG0789	Transcriptional regulator
Ththe16_1508	COG0484	heat shock protein binding
Ththe16_1509	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Ththe16_1510	COG0443	Heat shock 70 kDa protein
Ththe16_1511	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ththe16_1512	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Ththe16_1513	COG0616	signal peptide processing
Ththe16_1516	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
Ththe16_1517	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ththe16_1518	COG0714	Associated with various cellular activities
Ththe16_1519	COG0574	Belongs to the PEP-utilizing enzyme family
Ththe16_1519	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ththe16_1520	COG1272	protein, Hemolysin III
Ththe16_1522	COG5002	protein histidine kinase activity
Ththe16_1522	COG3850	Histidine kinase
Ththe16_1526	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Ththe16_1533	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Ththe16_1536	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Ththe16_1538	COG0047	phosphoribosylformylglycinamidine synthase activity
Ththe16_1540	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ththe16_1541	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Ththe16_1542	COG0116	Belongs to the methyltransferase superfamily
Ththe16_1545	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Ththe16_1546	COG0497	DNA recombination
Ththe16_1548	COG0604	alcohol dehydrogenase
Ththe16_1552	COG0585	pseudouridine synthase activity
Ththe16_1555	COG0557	exoribonuclease II activity
Ththe16_1556	COG0538	isocitrate dehydrogenase activity
Ththe16_1562	COG2050	protein possibly involved in aromatic compounds catabolism
Ththe16_1564	COG0322	excinuclease ABC activity
Ththe16_1565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ththe16_1566	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Ththe16_1567	COG1854	S-ribosylhomocysteine lyase activity
Ththe16_1570	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ththe16_1570	COG0519	Catalyzes the synthesis of GMP from XMP
Ththe16_1571	COG4636	protein conserved in cyanobacteria
Ththe16_1572	COG4274	PFAM GYD family protein
Ththe16_1573	COG0346	lactoylglutathione lyase activity
Ththe16_1574	COG0328	RNA-DNA hybrid ribonuclease activity
Ththe16_1575	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Ththe16_1576	COG2095	MarC family integral membrane protein
Ththe16_1577	COG1438	arginine binding
Ththe16_1578	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Ththe16_1579	COG1758	RNA polymerase activity
Ththe16_1580	COG0194	GDP metabolic process
Ththe16_1582	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Ththe16_1583	COG2385	sporulation resulting in formation of a cellular spore
Ththe16_1584	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
Ththe16_1586	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
Ththe16_1594	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Ththe16_1595	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Ththe16_1596	COG1012	belongs to the aldehyde dehydrogenase family
Ththe16_1597	COG0506	proline dehydrogenase activity
Ththe16_1603	COG0156	8-amino-7-oxononanoate synthase activity
Ththe16_1604	COG0732	type I restriction modification DNA specificity domain
Ththe16_1604	COG0827	DNA restriction-modification system
Ththe16_1606	COG0187	DNA topoisomerase II activity
Ththe16_1607	COG1181	Belongs to the D-alanine--D-alanine ligase family
Ththe16_1608	COG0193	aminoacyl-tRNA hydrolase activity
Ththe16_1609	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Ththe16_1614	COG0515	serine threonine protein kinase
Ththe16_1614	COG2815	serine threonine protein kinase
Ththe16_1615	COG0631	protein serine/threonine phosphatase activity
Ththe16_1618	COG0113	porphobilinogen synthase activity
Ththe16_1619	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Ththe16_1620	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Ththe16_1625	COG4946	Tricorn protease homolog
Ththe16_1625	COG1506	peptidase
Ththe16_1625	COG0823	Involved in the tonB-independent uptake of proteins
Ththe16_1626	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Ththe16_1627	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Ththe16_1631	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Ththe16_1632	COG1011	Hydrolase
Ththe16_1637	COG0537	adenosine 5'-monophosphoramidase activity
Ththe16_1638	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ththe16_1639	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Ththe16_1640	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Ththe16_1641	COG0071	Belongs to the small heat shock protein (HSP20) family
Ththe16_1642	COG2897	thiosulfate sulfurtransferase activity
Ththe16_1643	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ththe16_1645	COG1764	response to oxidative stress
Ththe16_1648	COG1840	ABC-type Fe3 transport system, periplasmic component
Ththe16_1650	COG3842	ATPase activity
Ththe16_1651	COG0101	tRNA pseudouridine synthase activity
Ththe16_1652	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ththe16_1653	COG0601	transmembrane transport
Ththe16_1655	COG0316	Belongs to the HesB IscA family
Ththe16_1656	COG0006	proline dipeptidase activity
Ththe16_1657	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ththe16_1660	COG1166	arginine decarboxylase activity
Ththe16_1661	COG3706	GGDEF domain
Ththe16_1662	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Ththe16_1663	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
Ththe16_1664	COG1611	Belongs to the LOG family
Ththe16_1665	COG1193	negative regulation of DNA recombination
Ththe16_1666	COG0366	Alpha amylase catalytic
Ththe16_1667	COG3833	ABC-type maltose transport systems, permease component
Ththe16_1668	COG1175	transmembrane transport
Ththe16_1671	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Ththe16_1672	COG0142	geranyltranstransferase activity
Ththe16_1681	COG0203	ribosomal protein L17
Ththe16_1682	COG0202	RNA polymerase activity
Ththe16_1683	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Ththe16_1684	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Ththe16_1685	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
Ththe16_1686	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Ththe16_1687	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Ththe16_1689	COG0563	adenylate kinase activity
Ththe16_1690	COG0201	protein transport
Ththe16_1691	COG0200	Binds to the 23S rRNA
Ththe16_1692	COG1841	ribosomal large subunit assembly
Ththe16_1693	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Ththe16_1694	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Ththe16_1695	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Ththe16_1696	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Ththe16_1697	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Ththe16_1698	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Ththe16_1699	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Ththe16_1701	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Ththe16_1702	COG0255	Belongs to the universal ribosomal protein uL29 family
Ththe16_1703	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Ththe16_1704	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
Ththe16_1705	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Ththe16_1706	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
Ththe16_1707	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Ththe16_1708	COG0089	rRNA binding
Ththe16_1709	COG0088	Forms part of the polypeptide exit tunnel
Ththe16_1710	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Ththe16_1711	COG0051	transcription antitermination factor activity, RNA binding
Ththe16_1712	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ththe16_1713	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ththe16_1714	COG0049	tRNA binding
Ththe16_1715	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
Ththe16_1717	COG0442	prolyl-tRNA aminoacylation
Ththe16_1719	COG1115	amino acid carrier protein
Ththe16_1723	COG1489	DNA binding
Ththe16_1730	COG0432	Pfam Uncharacterised protein family UPF0047
Ththe16_1732	COG0668	transmembrane transport
Ththe16_1734	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Ththe16_1735	COG2217	Heavy metal translocating P-type atpase
Ththe16_1739	COG0745	RESPONSE REGULATOR receiver
Ththe16_1740	COG2205	protein histidine kinase activity
Ththe16_1748	COG2132	Multicopper oxidase
Ththe16_1751	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ththe16_1752	COG0822	iron-sulfur transferase activity
Ththe16_1756	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Ththe16_1758	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ththe16_1759	COG0284	orotidine-5'-phosphate decarboxylase activity
Ththe16_1760	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Ththe16_1761	COG1371	PFAM Archease protein family (DUF101 UPF0211)
Ththe16_1762	COG0416	fatty acid biosynthetic process
Ththe16_1763	COG3118	belongs to the thioredoxin family
Ththe16_1764	COG1185	polyribonucleotide nucleotidyltransferase activity
Ththe16_1767	COG0438	transferase activity, transferring glycosyl groups
Ththe16_1770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ththe16_1773	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ththe16_1774	COG3706	GGDEF domain
Ththe16_1781	COG0437	4 iron, 4 sulfur cluster binding
Ththe16_1784	COG0825	malonyl-CoA metabolic process
Ththe16_1785	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Ththe16_1792	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Ththe16_1797	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Ththe16_1798	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ththe16_1799	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Ththe16_1800	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Ththe16_1806	COG0315	cyclic pyranopterin monophosphate synthase activity
Ththe16_1808	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Ththe16_1811	COG0477	Major facilitator Superfamily
Ththe16_1812	COG1694	Mazg nucleotide pyrophosphohydrolase
Ththe16_1813	COG1803	Methylglyoxal synthase
Ththe16_1815	COG0301	tRNA thio-modification
Ththe16_1816	COG0154	amidase activity
Ththe16_1820	COG2154	pterin-4-alpha-carbinolamine dehydratase
Ththe16_1821	COG1607	acyl-coa hydrolase
Ththe16_1823	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Ththe16_1824	COG4149	molybdate abc transporter
Ththe16_1825	COG1840	ABC-type Fe3 transport system, periplasmic component
Ththe16_1828	COG0235	Class ii aldolase
Ththe16_1829	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Ththe16_1830	COG0085	RNA polymerase activity
Ththe16_1832	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ththe16_1833	COG1077	Cell shape determining protein MreB Mrl
Ththe16_1834	COG1418	mRNA catabolic process
Ththe16_1834	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Ththe16_1835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Ththe16_1836	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Ththe16_1837	COG1058	Belongs to the CinA family
Ththe16_1837	COG1546	Belongs to the CinA family
Ththe16_1838	COG0354	folic acid binding
Ththe16_1844	COG1175	transmembrane transport
Ththe16_1846	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Ththe16_1848	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Ththe16_1850	COG0577	efflux transmembrane transporter activity
Ththe16_1850	COG1136	(ABC) transporter
Ththe16_1851	COG4181	ATPase activity
Ththe16_1852	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ththe16_1855	COG0396	ATPase activity
Ththe16_1856	COG0719	Fe-S assembly protein
Ththe16_1857	COG0719	Fe-S assembly protein
Ththe16_1858	COG2146	nitrite reductase [NAD(P)H] activity
Ththe16_1859	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ththe16_1860	COG0512	Glutamine amidotransferase of anthranilate synthase
Ththe16_1861	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ththe16_1866	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ththe16_1867	COG2226	methyltransferase
Ththe16_1872	COG1774	PSP1 C-terminal conserved region
Ththe16_1873	COG0470	DNA polymerase III
Ththe16_1879	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ththe16_1882	COG0302	gtp cyclohydrolase
Ththe16_1888	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ththe16_1890	COG0395	ABC-type sugar transport system, permease component
Ththe16_1891	COG1131	(ABC) transporter
Ththe16_1895	COG0556	nucleotide-excision repair
Ththe16_1896	COG0497	DNA recombination
Ththe16_1897	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Ththe16_1898	COG0445	tRNA wobble uridine modification
Ththe16_1903	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ththe16_1903	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Ththe16_1904	COG1543	Belongs to the glycosyl hydrolase 57 family
Ththe16_1905	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Ththe16_1906	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Ththe16_1907	COG0189	ligase activity
Ththe16_1910	COG0066	3-isopropylmalate dehydratase activity
Ththe16_1911	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ththe16_1915	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Ththe16_1916	COG1960	acyl-CoA dehydrogenase activity
Ththe16_1917	COG0163	prenyltransferase activity
Ththe16_1923	COG4555	ABC transporter
Ththe16_1928	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Ththe16_1929	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Ththe16_1931	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Ththe16_1932	COG0723	plastoquinol--plastocyanin reductase activity
Ththe16_1937	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Ththe16_1938	COG1960	acyl-CoA dehydrogenase activity
Ththe16_1940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Ththe16_1944	COG0393	Putative heavy-metal-binding
Ththe16_1946	COG3956	TIGRFAM MazG family protein
Ththe16_1948	COG0693	protein deglycase activity
Ththe16_1949	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Ththe16_1951	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Ththe16_1952	COG1937	Protein conserved in bacteria
Ththe16_1954	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ththe16_1954	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ththe16_1955	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ththe16_1956	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ththe16_1957	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Ththe16_1958	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ththe16_1958	COG0072	phenylalanine-tRNA ligase activity
Ththe16_1960	COG0205	6-phosphofructokinase activity
Ththe16_1961	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Ththe16_1963	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Ththe16_1966	COG0658	competence protein
Ththe16_1966	COG2333	competence protein COMEC
Ththe16_1967	COG1475	DNA binding
Ththe16_1968	COG1192	Involved in chromosome partitioning
Ththe16_1969	COG0357	Ribosomal RNA small subunit methyltransferase G
Ththe16_1970	COG0445	tRNA wobble uridine modification
Ththe16_1973	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Ththe16_1974	COG0534	Mate efflux family protein
Ththe16_1976	COG3328	transposase activity
Ththe16_1982	COG0525	valine-tRNA ligase activity
Ththe16_1985	COG3328	transposase activity
Ththe16_1987	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Ththe16_1988	COG1607	acyl-coa hydrolase
Ththe16_1990	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Ththe16_2012	COG0497	DNA recombination
Ththe16_2013	COG3854	ATPases associated with a variety of cellular activities
Ththe16_2028	COG2002	toxin-antitoxin pair type II binding
Ththe16_2036	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Ththe16_2047	COG1349	DNA-binding transcription factor activity
Ththe16_2048	COG3718	enzyme involved in inositol metabolism
Ththe16_2049	COG0673	inositol 2-dehydrogenase activity
Ththe16_2051	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ththe16_2053	COG3962	Belongs to the TPP enzyme family
Ththe16_2054	COG1129	ABC transporter
Ththe16_2055	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ththe16_2056	COG1012	belongs to the aldehyde dehydrogenase family
Ththe16_2062	COG1192	Involved in chromosome partitioning
Ththe16_2063	COG1475	DNA binding
Ththe16_2064	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ththe16_2075	COG1203	CRISPR-associated helicase, Cas3
Ththe16_2078	COG1074	ATP-dependent DNA helicase activity
Ththe16_2082	COG3335	DDE superfamily endonuclease
Ththe16_2092	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Ththe16_2107	COG4974	Belongs to the 'phage' integrase family
Ththe16_2114	COG2329	Antibiotic biosynthesis monooxygenase
Ththe16_2129	COG3335	DDE superfamily endonuclease
Ththe16_2137	COG1475	DNA binding
Ththe16_2143	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Ththe16_2145	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ththe16_2146	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ththe16_2151	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
Ththe16_2158	COG1518	maintenance of DNA repeat elements
Ththe16_2159	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
Ththe16_2161	COG0863	Belongs to the N(4) N(6)-methyltransferase family
Ththe16_2165	COG1609	Transcriptional regulator
Ththe16_2167	COG1175	transmembrane transport
Ththe16_2168	COG0395	ABC-type sugar transport system, permease component
Ththe16_2171	COG1012	belongs to the aldehyde dehydrogenase family
Ththe16_2172	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Ththe16_2174	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ththe16_2175	COG0747	negative chemotaxis
Ththe16_2182	COG1110	DNA topoisomerase II activity
Ththe16_2185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Ththe16_2187	COG2076	Multidrug Resistance protein
Ththe16_2188	COG0395	ABC-type sugar transport system, permease component
Ththe16_2189	COG1175	transmembrane transport
Ththe16_2193	COG1737	Transcriptional regulator
Ththe16_2194	COG0584	glycerophosphoryl diester phosphodiesterase
Ththe16_2196	COG2814	Major facilitator Superfamily
Ththe16_2198	COG2151	metal-sulfur cluster biosynthetic enzyme
Ththe16_2205	COG2181	nitrate reductase activity
Ththe16_2208	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Ththe16_2209	COG2010	Cytochrome c
Ththe16_2211	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ththe16_2212	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Ththe16_2226	COG2010	Cytochrome c
Ththe16_2227	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Ththe16_2230	COG3256	nitric oxide reductase
Ththe16_2242	COG1192	Involved in chromosome partitioning
Ththe16_2243	COG1475	DNA binding
Ththe16_2253	COG3335	DDE superfamily endonuclease
Ththe16_2257	COG1349	DNA-binding transcription factor activity
Ththe16_2258	COG1653	transport
Ththe16_2260	COG0395	ABC-type sugar transport system, permease component
Ththe16_2262	COG3345	alpha-galactosidase
Ththe16_2263	COG1085	galactose-1-phosphate uridylyltransferase
Ththe16_2266	COG1304	FMN binding
Ththe16_2268	COG1487	ribonuclease activity
Ththe16_2270	COG0463	Glycosyl transferase, family 2
Ththe16_2277	COG1562	ergosterol biosynthetic process
Ththe16_2279	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ththe16_2281	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Ththe16_2282	COG2723	6-phospho-beta-galactosidase activity
Ththe16_2284	COG1175	transmembrane transport
Ththe16_2287	COG1028	Short-chain dehydrogenase reductase Sdr
Ththe16_2290	COG1028	Short-chain dehydrogenase reductase Sdr
Ththe16_2291	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
Ththe16_2293	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Ththe16_2294	COG1414	Transcriptional regulator
Ththe16_2301	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Ththe16_2302	COG1785	Belongs to the alkaline phosphatase family
Ththe16_2303	COG1492	cobalamin metabolic process
Ththe16_2306	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ththe16_2310	COG0778	Nitroreductase
Ththe16_2311	COG1648	precorrin-2 dehydrogenase activity
Ththe16_2311	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ththe16_2320	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
Ththe16_2321	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Ththe16_2322	COG0588	phosphoglycerate mutase activity
Ththe16_2325	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Ththe16_2327	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Ththe16_2328	COG1797	cobyrinic acid a,c-diamide synthase activity
Ththe16_2344	COG0747	negative chemotaxis
Ththe16_2345	COG0601	transmembrane transport
Ththe16_2346	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ththe16_2348	COG4608	Belongs to the ABC transporter superfamily
Ththe16_2354	COG0298	carbon dioxide binding
Ththe16_2356	COG0409	Hydrogenase expression formation protein
Ththe16_2358	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Ththe16_2360	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Ththe16_2361	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Ththe16_2362	COG1595	DNA-templated transcription, initiation
Ththe16_2366	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Ththe16_2369	COG0375	protein maturation
Ththe16_2370	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Ththe16_2379	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Ththe16_2386	COG1525	nuclease
Ththe16_R0039	COG0544	peptidyl-prolyl cis-trans isomerase activity