locus-tag	class	description
TthSNM11_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TthSNM11_00020	COG0592	DNA-directed DNA polymerase activity
TthSNM11_00030	COG0148	phosphopyruvate hydratase activity
TthSNM11_00040	COG0469	pyruvate kinase activity
TthSNM11_00060	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM11_00070	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
TthSNM11_00090	COG1842	Phage shock protein A
TthSNM11_00100	COG0406	alpha-ribazole phosphatase activity
TthSNM11_00110	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
TthSNM11_00120	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM11_00140	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
TthSNM11_00150	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
TthSNM11_00160	COG1496	oxidoreductase activity
TthSNM11_00170	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
TthSNM11_00180	COG1278	Cold shock
TthSNM11_00250	COG1335	isochorismatase
TthSNM11_00260	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
TthSNM11_00280	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM11_00300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
TthSNM11_00310	COG1993	acr, cog1993
TthSNM11_00320	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
TthSNM11_00330	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
TthSNM11_00380	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthSNM11_00390	COG0436	Aminotransferase
TthSNM11_00400	COG0285	dihydrofolate synthase activity
TthSNM11_00420	COG0181	hydroxymethylbilane synthase activity
TthSNM11_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TthSNM11_00450	COG1950	PFAM Membrane protein of
TthSNM11_00460	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
TthSNM11_00460	COG0517	IMP dehydrogenase activity
TthSNM11_00480	COG2814	Major facilitator Superfamily
TthSNM11_00500	COG0033	Phosphoglucomutase
TthSNM11_00550	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
TthSNM11_00580	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
TthSNM11_00590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
TthSNM11_00630	COG1660	Displays ATPase and GTPase activities
TthSNM11_00640	COG0391	Required for morphogenesis under gluconeogenic growth conditions
TthSNM11_00700	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM11_00700	COG1845	cytochrome c oxidase, subunit III
TthSNM11_00710	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM11_00710	COG2010	Cytochrome c
TthSNM11_00720	COG0109	protoheme IX farnesyltransferase activity
TthSNM11_00720	COG1612	heme a metabolic process
TthSNM11_00750	COG0343	queuine tRNA-ribosyltransferase activity
TthSNM11_00760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
TthSNM11_00770	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TthSNM11_00820	COG1940	carbohydrate kinase activity
TthSNM11_00840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM11_00850	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM11_00870	COG1611	Belongs to the LOG family
TthSNM11_00890	COG1011	Hydrolase
TthSNM11_00900	COG0632	four-way junction helicase activity
TthSNM11_00910	COG1024	Enoyl-CoA hydratase
TthSNM11_00930	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM11_00950	COG1404	Belongs to the peptidase S8 family
TthSNM11_00970	COG0137	argininosuccinate synthase activity
TthSNM11_00980	COG0165	Argininosuccinate lyase
TthSNM11_01010	COG0505	Belongs to the CarA family
TthSNM11_01030	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
TthSNM11_01040	COG0166	Belongs to the GPI family
TthSNM11_01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM11_01070	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
TthSNM11_01080	COG0459	protein refolding
TthSNM11_01090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
TthSNM11_01100	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
TthSNM11_01120	COG0778	Nitroreductase
TthSNM11_01130	COG1388	LysM domain
TthSNM11_01130	COG0791	NLP P60 protein
TthSNM11_01150	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
TthSNM11_01170	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TthSNM11_01180	COG0581	inorganic phosphate transmembrane transporter activity
TthSNM11_01190	COG0573	inorganic phosphate transmembrane transporter activity
TthSNM11_01200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TthSNM11_01210	COG0482	sulfurtransferase activity
TthSNM11_01230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TthSNM11_01240	COG0735	belongs to the Fur family
TthSNM11_01270	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
TthSNM11_01280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM11_01290	COG0267	Belongs to the bacterial ribosomal protein bL33 family
TthSNM11_01300	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TthSNM11_01310	COG0250	Participates in transcription elongation, termination and antitermination
TthSNM11_01330	COG0081	regulation of translation
TthSNM11_01380	COG0629	single-stranded DNA binding
TthSNM11_01390	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
TthSNM11_01400	COG0359	binds to the 23S rRNA
TthSNM11_01420	COG0300	oxidoreductase activity
TthSNM11_01430	COG0321	lipoyl(octanoyl) transferase activity
TthSNM11_01440	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
TthSNM11_01550	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TthSNM11_01580	COG1598	PFAM Uncharacterised protein family UPF0150
TthSNM11_01590	COG0022	dehydrogenase e1 component
TthSNM11_01600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TthSNM11_01610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
TthSNM11_01660	COG2226	methyltransferase
TthSNM11_01670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
TthSNM11_01690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
TthSNM11_01700	COG1187	pseudouridine synthase activity
TthSNM11_01720	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
TthSNM11_01730	COG0686	Belongs to the AlaDH PNT family
TthSNM11_01750	COG1461	Dihydroxyacetone kinase
TthSNM11_01770	COG3583	domain protein
TthSNM11_01770	COG3584	3D domain protein
TthSNM11_01780	COG4591	ABC-type transport system involved in lipoprotein release permease component
TthSNM11_01790	COG0222	ribosome binding
TthSNM11_01800	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
TthSNM11_01830	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
TthSNM11_01860	COG0697	spore germination
TthSNM11_01880	COG3177	Filamentation induced by cAMP protein fic
TthSNM11_01900	COG0243	molybdopterin cofactor binding
TthSNM11_01950	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
TthSNM11_01970	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM11_02030	COG0477	Major facilitator Superfamily
TthSNM11_02060	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
TthSNM11_02080	COG0105	UTP biosynthetic process
TthSNM11_02090	COG0631	protein serine/threonine phosphatase activity
TthSNM11_02100	COG0583	DNA-binding transcription factor activity
TthSNM11_02120	COG0508	dehydrogenase complex catalyzes the overall conversion of
TthSNM11_02190	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM11_02210	COG1278	Cold shock
TthSNM11_02220	COG0484	heat shock protein binding
TthSNM11_02230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
TthSNM11_02240	COG1968	undecaprenyl-diphosphatase activity
TthSNM11_02250	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
TthSNM11_02260	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
TthSNM11_02290	COG1309	transcriptional regulator
TthSNM11_02300	COG4242	Belongs to the peptidase S51 family
TthSNM11_02330	COG0802	atpase or kinase
TthSNM11_02340	COG0539	negative regulation of cytoplasmic translation
TthSNM11_02350	COG0495	leucyl-tRNA aminoacylation
TthSNM11_02390	COG1902	pentaerythritol trinitrate reductase activity
TthSNM11_02440	COG2414	aldehyde ferredoxin oxidoreductase
TthSNM11_02480	COG1187	pseudouridine synthase activity
TthSNM11_02500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM11_02510	COG0745	RESPONSE REGULATOR receiver
TthSNM11_02520	COG4191	Histidine kinase
TthSNM11_02530	COG0704	Plays a role in the regulation of phosphate uptake
TthSNM11_02540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
TthSNM11_02560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
TthSNM11_02580	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TthSNM11_02580	COG0515	serine threonine protein kinase
TthSNM11_02620	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
TthSNM11_02630	COG0300	oxidoreductase activity
TthSNM11_02660	COG0717	Belongs to the dCTP deaminase family
TthSNM11_02670	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
TthSNM11_02680	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
TthSNM11_02690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TthSNM11_02740	COG3546	catalase activity
TthSNM11_02750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM11_02750	COG0758	DNA mediated transformation
TthSNM11_02760	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
TthSNM11_02780	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM11_02800	COG3635	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity
TthSNM11_02810	COG0442	prolyl-tRNA aminoacylation
TthSNM11_02820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
TthSNM11_02880	COG0513	Belongs to the DEAD box helicase family
TthSNM11_02940	COG4983	Phage plasmid primase, P4 family domain protein
TthSNM11_03020	COG0582	viral genome integration into host DNA
TthSNM11_03050	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
TthSNM11_03080	COG2070	2-Nitropropane dioxygenase
TthSNM11_03110	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
TthSNM11_03120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM11_03130	COG0018	arginyl-trna synthetase
TthSNM11_03140	COG1007	ATP synthesis coupled electron transport
TthSNM11_03150	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM11_03160	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
TthSNM11_03170	COG0713	ATP synthesis coupled electron transport
TthSNM11_03180	COG0839	Belongs to the complex I subunit 6 family
TthSNM11_03190	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM11_03200	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
TthSNM11_03210	COG1034	ATP synthesis coupled electron transport
TthSNM11_03220	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TthSNM11_03230	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TthSNM11_03240	COG0649	NAD binding
TthSNM11_03250	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM11_03260	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM11_03270	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TthSNM11_03280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
TthSNM11_03300	COG4712	double-strand break repair protein
TthSNM11_03320	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthSNM11_03350	COG0135	phosphoribosylanthranilate isomerase activity
TthSNM11_03360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TthSNM11_03360	COG1372	Participates in initiation and elongation during chromosome replication
TthSNM11_03370	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
TthSNM11_03390	COG2720	vancomycin resistance protein
TthSNM11_03400	COG1126	abc transporter atp-binding protein
TthSNM11_03460	COG0277	FAD linked oxidase domain protein
TthSNM11_03490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
TthSNM11_03500	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
TthSNM11_03530	COG0314	molybdopterin synthase activity
TthSNM11_03540	COG1420	regulation of RNA biosynthetic process
TthSNM11_03550	COG0347	Belongs to the P(II) protein family
TthSNM11_03580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TthSNM11_03600	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM11_03640	COG1597	lipid kinase activity
TthSNM11_03650	COG0436	Aminotransferase
TthSNM11_03690	COG0569	domain protein
TthSNM11_03690	COG0475	glutathione-regulated potassium exporter activity
TthSNM11_03710	COG0227	Belongs to the bacterial ribosomal protein bL28 family
TthSNM11_03730	COG0277	FAD linked oxidase domain protein
TthSNM11_03790	COG2002	toxin-antitoxin pair type II binding
TthSNM11_03870	COG0667	Aldo Keto reductase
TthSNM11_03910	COG1067	ATP-dependent peptidase activity
TthSNM11_03920	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
TthSNM11_03950	COG0745	RESPONSE REGULATOR receiver
TthSNM11_03960	COG2105	PFAM AIG2 family protein
TthSNM11_03970	COG0297	glycogen (starch) synthase activity
TthSNM11_03990	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthSNM11_04010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TthSNM11_04020	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
TthSNM11_04050	COG0142	geranyltranstransferase activity
TthSNM11_04070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
TthSNM11_04080	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM11_04090	COG0492	ferredoxin-NADP+ reductase activity
TthSNM11_04110	COG0792	nuclease activity
TthSNM11_04120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
TthSNM11_04150	COG1175	transmembrane transport
TthSNM11_04160	COG0395	ABC-type sugar transport system, permease component
TthSNM11_04220	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
TthSNM11_04230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
TthSNM11_04240	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM11_04250	COG0805	protein transport
TthSNM11_04260	COG1605	Chorismate mutase
TthSNM11_04260	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM11_04280	COG3573	Dehydrogenase
TthSNM11_04380	COG1063	alcohol dehydrogenase
TthSNM11_04440	COG2255	four-way junction helicase activity
TthSNM11_04450	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
TthSNM11_04460	COG0564	pseudouridine synthase activity
TthSNM11_04490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TthSNM11_04500	COG0232	Belongs to the dGTPase family. Type 2 subfamily
TthSNM11_04510	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TthSNM11_04520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TthSNM11_04540	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TthSNM11_04550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
TthSNM11_04560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
TthSNM11_04650	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TthSNM11_04660	COG0131	Imidazoleglycerol-phosphate dehydratase
TthSNM11_04670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
TthSNM11_04680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TthSNM11_04690	COG0516	GMP reductase activity
TthSNM11_04690	COG0517	IMP dehydrogenase activity
TthSNM11_04720	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
TthSNM11_04750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM11_04800	COG0706	membrane insertase activity
TthSNM11_04810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
TthSNM11_04820	COG0594	ribonuclease P activity
TthSNM11_04840	COG1022	Amp-dependent synthetase and ligase
TthSNM11_04920	COG1121	(ABC) transporter
TthSNM11_04930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
TthSNM11_04940	COG1959	2 iron, 2 sulfur cluster binding
TthSNM11_04950	COG1104	cysteine desulfurase activity
TthSNM11_04960	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
TthSNM11_04970	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
TthSNM11_05000	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM11_05040	COG0492	ferredoxin-NADP+ reductase activity
TthSNM11_05050	COG0604	alcohol dehydrogenase
TthSNM11_05050	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM11_05050	COG3321	synthase
TthSNM11_05060	COG0747	negative chemotaxis
TthSNM11_05070	COG0601	transmembrane transport
TthSNM11_05080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM11_05110	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM11_05110	COG0617	tRNA 3'-terminal CCA addition
TthSNM11_05110	COG0517	IMP dehydrogenase activity
TthSNM11_05120	COG0123	including yeast histone deacetylase and acetoin utilization protein
TthSNM11_05130	COG2104	thiamine diphosphate biosynthetic process
TthSNM11_05140	COG0037	tRNA processing
TthSNM11_05160	COG0366	Alpha amylase catalytic
TthSNM11_05170	COG2226	methyltransferase
TthSNM11_05180	COG2226	methyltransferase
TthSNM11_05190	COG0815	Transfers the fatty acyl group on membrane lipoproteins
TthSNM11_05210	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
TthSNM11_05220	COG3744	PilT protein domain protein
TthSNM11_05240	COG0460	homoserine dehydrogenase
TthSNM11_05260	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
TthSNM11_05340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TthSNM11_05370	COG0247	lactate metabolic process
TthSNM11_05380	COG0277	FAD linked oxidase domain protein
TthSNM11_05390	COG0277	FAD linked oxidase domain protein
TthSNM11_05400	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
TthSNM11_05410	COG1414	Transcriptional regulator
TthSNM11_05420	COG0789	Transcriptional regulator
TthSNM11_05440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM11_05450	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
TthSNM11_05520	COG0861	Integral membrane protein TerC family
TthSNM11_05540	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM11_05550	COG0281	malic enzyme
TthSNM11_05580	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TthSNM11_05590	COG0509	glycine decarboxylation via glycine cleavage system
TthSNM11_05600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM11_05610	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
TthSNM11_05620	COG0196	riboflavin kinase activity
TthSNM11_05670	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthSNM11_05680	COG2813	Specifically methylates the guanine in position
TthSNM11_05690	COG0527	aspartate kinase activity
TthSNM11_05750	COG4956	integral membrane protein (PIN domain superfamily)
TthSNM11_05760	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
TthSNM11_05770	COG0542	response to heat
TthSNM11_05780	COG0423	glycine-tRNA ligase activity
TthSNM11_05810	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
TthSNM11_05850	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM11_05850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TthSNM11_05870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TthSNM11_05890	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
TthSNM11_05910	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM11_05920	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM11_05930	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TthSNM11_05940	COG0114	fumarate hydratase activity
TthSNM11_05950	COG0183	Belongs to the thiolase family
TthSNM11_05980	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
TthSNM11_05990	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TthSNM11_06020	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TthSNM11_06030	COG1254	Belongs to the acylphosphatase family
TthSNM11_06070	COG3335	DDE superfamily endonuclease
TthSNM11_06080	COG1063	alcohol dehydrogenase
TthSNM11_06090	COG2133	pyrroloquinoline quinone binding
TthSNM11_06110	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
TthSNM11_06120	COG0154	amidase activity
TthSNM11_06170	COG0572	uridine kinase
TthSNM11_06180	COG3842	ATPase activity
TthSNM11_06210	COG4475	Protein of unknown function (DUF436)
TthSNM11_06270	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TthSNM11_06280	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
TthSNM11_06290	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthSNM11_06320	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
TthSNM11_06330	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
TthSNM11_06340	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
TthSNM11_06350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TthSNM11_06370	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM11_06400	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
TthSNM11_06410	COG1293	RNA-binding protein homologous to eukaryotic snRNP
TthSNM11_06420	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
TthSNM11_06440	COG3870	Protein conserved in bacteria
TthSNM11_06450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
TthSNM11_06470	COG0544	peptidyl-prolyl cis-trans isomerase activity
TthSNM11_06480	COG0740	serine-type endopeptidase activity
TthSNM11_06490	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
TthSNM11_06500	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
TthSNM11_06510	COG1410	methionine synthase
TthSNM11_06510	COG0646	methionine synthase
TthSNM11_06530	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM11_06580	COG1692	metallophosphoesterase
TthSNM11_06590	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
TthSNM11_06600	COG1970	mechanosensitive ion channel activity
TthSNM11_06710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TthSNM11_06730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
TthSNM11_06740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
TthSNM11_06850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
TthSNM11_06880	COG1215	transferase activity, transferring glycosyl groups
TthSNM11_06900	COG1216	Glycosyl transferase, family 2
TthSNM11_06930	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM11_06970	COG0489	protein tyrosine kinase activity
TthSNM11_06990	COG2264	protein methyltransferase activity
TthSNM11_07000	COG1385	rRNA (uridine-N3-)-methyltransferase activity
TthSNM11_07070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TthSNM11_07080	COG2046	Belongs to the sulfate adenylyltransferase family
TthSNM11_07090	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM11_07090	COG1648	precorrin-2 dehydrogenase activity
TthSNM11_07100	COG0730	response to heat
TthSNM11_07110	COG0175	sulfate reduction
TthSNM11_07120	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TthSNM11_07120	COG1648	precorrin-2 dehydrogenase activity
TthSNM11_07130	COG1587	Uroporphyrinogen-III synthase
TthSNM11_07140	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TthSNM11_07160	COG0352	thiamine-phosphate diphosphorylase activity
TthSNM11_07170	COG2104	thiamine diphosphate biosynthetic process
TthSNM11_07180	COG2022	thiamine diphosphate biosynthetic process
TthSNM11_07190	COG2022	thiamine diphosphate biosynthetic process
TthSNM11_07190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM11_07200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
TthSNM11_07210	COG0477	Major facilitator Superfamily
TthSNM11_07220	COG0351	phosphomethylpyrimidine kinase
TthSNM11_07280	COG1175	transmembrane transport
TthSNM11_07300	COG1940	carbohydrate kinase activity
TthSNM11_07310	COG0183	Belongs to the thiolase family
TthSNM11_07340	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM11_07380	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM11_07380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
TthSNM11_07400	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
TthSNM11_07420	COG0195	Participates in both transcription termination and antitermination
TthSNM11_07430	COG0779	Required for maturation of 30S ribosomal subunits
TthSNM11_07440	COG0739	heme binding
TthSNM11_07450	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
TthSNM11_07460	COG0640	Transcriptional regulator
TthSNM11_07470	COG2217	Heavy metal translocating P-type atpase
TthSNM11_07480	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
TthSNM11_07490	COG0017	Asparaginyl-tRNA synthetase
TthSNM11_07500	COG0561	phosphatase activity
TthSNM11_07510	COG0384	phenazine biosynthesis protein PhzF
TthSNM11_07530	COG0124	histidyl-tRNA synthetase
TthSNM11_07550	COG3842	ATPase activity
TthSNM11_07580	COG1573	uracil-dna glycosylase
TthSNM11_07620	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
TthSNM11_07650	COG1316	TRANSCRIPTIONal
TthSNM11_07660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TthSNM11_07750	COG0295	cytidine deaminase activity
TthSNM11_07770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM11_07790	COG1760	l-serine dehydratase
TthSNM11_07800	COG1760	l-serine dehydratase
TthSNM11_07820	COG0481	GTPase activity
TthSNM11_07840	COG0463	Glycosyl transferase, family 2
TthSNM11_07870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TthSNM11_07900	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM11_07960	COG0405	Gamma-glutamyltransferase
TthSNM11_07970	COG1073	alpha beta
TthSNM11_08000	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
TthSNM11_08010	COG2873	o-acetylhomoserine
TthSNM11_08040	COG1063	alcohol dehydrogenase
TthSNM11_08070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM11_08080	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM11_08090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TthSNM11_08100	COG1116	anion transmembrane transporter activity
TthSNM11_08100	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthSNM11_08110	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TthSNM11_08130	COG0167	dihydroorotate dehydrogenase activity
TthSNM11_08160	COG0540	Belongs to the ATCase OTCase family
TthSNM11_08170	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
TthSNM11_08190	COG0730	response to heat
TthSNM11_08200	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
TthSNM11_08220	COG1960	acyl-CoA dehydrogenase activity
TthSNM11_08230	COG0456	acetyltransferase
TthSNM11_08250	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TthSNM11_08260	COG0009	L-threonylcarbamoyladenylate synthase
TthSNM11_08270	COG1459	type II secretion system
TthSNM11_08300	COG0277	FAD linked oxidase domain protein
TthSNM11_08340	COG0287	Prephenate dehydrogenase
TthSNM11_08350	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
TthSNM11_08360	COG2514	catechol 2,3-dioxygenase activity
TthSNM11_08370	COG2353	YceI-like domain
TthSNM11_08380	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM11_08390	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM11_08460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM11_08470	COG0179	Fumarylacetoacetate (FAA) hydrolase
TthSNM11_08490	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TthSNM11_08500	COG0151	Belongs to the GarS family
TthSNM11_08510	COG5002	protein histidine kinase activity
TthSNM11_08510	COG2176	DNA-directed DNA polymerase activity
TthSNM11_08570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
TthSNM11_08590	COG0217	transcriptional regulatory protein
TthSNM11_08600	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TthSNM11_08600	COG4651	solute:proton antiporter activity
TthSNM11_08610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TthSNM11_08620	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
TthSNM11_08630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM11_08640	COG1674	ftsk spoiiie
TthSNM11_08670	COG0517	IMP dehydrogenase activity
TthSNM11_08690	COG0617	tRNA 3'-terminal CCA addition
TthSNM11_08690	COG3620	sequence-specific DNA binding
TthSNM11_08690	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM11_08710	COG1994	Peptidase M50
TthSNM11_08720	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
TthSNM11_08740	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM11_08770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
TthSNM11_08790	COG2719	SpoVR family
TthSNM11_08800	COG2718	Belongs to the UPF0229 family
TthSNM11_08810	COG2766	serine protein kinase
TthSNM11_08860	COG2137	regulation of response to DNA damage stimulus
TthSNM11_08880	COG2359	stage V sporulation protein S
TthSNM11_08890	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM11_08900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
TthSNM11_08920	COG0463	Glycosyl transferase, family 2
TthSNM11_08930	COG0750	zinc metalloprotease
TthSNM11_08940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
TthSNM11_08950	COG4589	Belongs to the CDS family
TthSNM11_08960	COG0233	cytoplasmic translational termination
TthSNM11_08970	COG0528	UMP kinase activity
TthSNM11_08980	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
TthSNM11_08990	COG0052	Belongs to the universal ribosomal protein uS2 family
TthSNM11_09000	COG0582	viral genome integration into host DNA
TthSNM11_09140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
TthSNM11_09150	COG0494	nUDIX hydrolase
TthSNM11_09210	COG0402	S-adenosylhomocysteine deaminase activity
TthSNM11_09230	COG4948	Mandelate Racemase Muconate Lactonizing
TthSNM11_09240	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
TthSNM11_09250	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
TthSNM11_09260	COG1811	Na channel or pump
TthSNM11_09270	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
TthSNM11_09270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM11_09300	COG1215	transferase activity, transferring glycosyl groups
TthSNM11_09320	COG1215	transferase activity, transferring glycosyl groups
TthSNM11_09340	COG0438	transferase activity, transferring glycosyl groups
TthSNM11_09350	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
TthSNM11_09380	COG1024	Enoyl-CoA hydratase
TthSNM11_09380	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM11_09390	COG0183	Belongs to the thiolase family
TthSNM11_09400	COG1960	acyl-CoA dehydrogenase activity
TthSNM11_09410	COG0215	cysteine-tRNA ligase activity
TthSNM11_09420	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TthSNM11_09440	COG2738	Putative neutral zinc metallopeptidase
TthSNM11_09480	COG1196	nuclear chromosome segregation
TthSNM11_09510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
TthSNM11_09520	COG3153	acetyltransferase
TthSNM11_09520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM11_09530	COG1268	BioY protein
TthSNM11_09550	COG0126	phosphoglycerate kinase activity
TthSNM11_09560	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
TthSNM11_09570	COG0824	Thioesterase
TthSNM11_09590	COG0557	exoribonuclease II activity
TthSNM11_09610	COG1355	regulation of microtubule-based process
TthSNM11_09620	COG1353	crispr-associated protein
TthSNM11_09620	COG0617	tRNA 3'-terminal CCA addition
TthSNM11_09630	COG0237	dephospho-CoA kinase activity
TthSNM11_09650	COG0742	ribosomal rna small subunit methyltransferase
TthSNM11_09660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
TthSNM11_09670	COG0138	bifunctional purine biosynthesis protein purh
TthSNM11_09680	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
TthSNM11_09710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
TthSNM11_09910	COG0149	triose-phosphate isomerase activity
TthSNM11_09920	COG3239	Fatty acid desaturase
TthSNM11_09930	COG1490	D-aminoacyl-tRNA deacylase activity
TthSNM11_09940	COG1307	EDD domain protein, DegV family
TthSNM11_09950	COG1307	EDD domain protein, DegV family
TthSNM11_09960	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TthSNM11_09990	COG3769	mannosylglycerate metabolic process
TthSNM11_10010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
TthSNM11_10030	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM11_10040	COG2368	4-hydroxyphenylacetate
TthSNM11_10230	COG0629	single-stranded DNA binding
TthSNM11_10330	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TthSNM11_10440	COG0497	DNA recombination
TthSNM11_10450	COG3854	ATPases associated with a variety of cellular activities
TthSNM11_10630	COG3335	DDE superfamily endonuclease
TthSNM11_10760	COG3335	DDE superfamily endonuclease
TthSNM11_10850	COG2165	general secretion pathway protein
TthSNM11_11330	COG0588	phosphoglycerate mutase activity
TthSNM11_11370	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM11_11390	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM11_11390	COG2030	dehydratase
TthSNM11_11400	COG1028	Short-chain dehydrogenase reductase Sdr
TthSNM11_11420	COG1960	acyl-CoA dehydrogenase activity
TthSNM11_11510	COG2723	6-phospho-beta-galactosidase activity
TthSNM11_11520	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM11_11560	COG1233	COG1233 Phytoene dehydrogenase and related
TthSNM11_11570	COG0702	epimerase
TthSNM11_11630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM11_11670	COG1562	ergosterol biosynthetic process
TthSNM11_11690	COG2124	cytochrome p450
TthSNM11_11740	COG1487	ribonuclease activity
TthSNM11_11760	COG1304	FMN binding
TthSNM11_11800	COG1085	galactose-1-phosphate uridylyltransferase
TthSNM11_11810	COG3345	alpha-galactosidase
TthSNM11_11840	COG1475	DNA binding
TthSNM11_11860	COG1475	DNA binding
TthSNM11_11870	COG1192	Involved in chromosome partitioning
TthSNM11_11910	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
TthSNM11_12030	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TthSNM11_12040	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM11_12050	COG1252	NADH dehydrogenase
TthSNM11_12090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM11_12160	COG2151	metal-sulfur cluster biosynthetic enzyme
TthSNM11_12170	COG2814	Major facilitator Superfamily
TthSNM11_12190	COG0584	glycerophosphoryl diester phosphodiesterase
TthSNM11_12210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
TthSNM11_12240	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
TthSNM11_12270	COG1337	RAMP superfamily
TthSNM11_12320	COG1111	helicase
TthSNM11_12320	COG1205	dead DEAH box helicase
TthSNM11_12370	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthSNM11_12670	COG3335	DDE superfamily endonuclease
TthSNM11_12730	COG3396	Phenylacetate-CoA oxygenase
TthSNM11_12750	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
TthSNM11_12780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
TthSNM11_12790	COG1607	acyl-coa hydrolase
TthSNM11_12810	COG1980	fructose-bisphosphate aldolase activity
TthSNM11_12820	COG1733	regulation of RNA biosynthetic process
TthSNM11_12830	COG2193	ferroxidase activity
TthSNM11_12840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
TthSNM11_12850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
TthSNM11_12890	COG1331	Highly conserved protein containing a thioredoxin domain
TthSNM11_12900	COG0183	Belongs to the thiolase family
TthSNM11_12910	COG1984	allophanate hydrolase subunit 2
TthSNM11_12980	COG2199	diguanylate cyclase activity
TthSNM11_12980	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
TthSNM11_12990	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM11_13020	COG0210	DNA helicase
TthSNM11_13070	COG0745	RESPONSE REGULATOR receiver
TthSNM11_13080	COG2205	protein histidine kinase activity
TthSNM11_13120	COG1136	(ABC) transporter
TthSNM11_13130	COG0577	efflux transmembrane transporter activity
TthSNM11_13130	COG1136	(ABC) transporter
TthSNM11_13240	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthSNM11_13390	COG0582	viral genome integration into host DNA
TthSNM11_13410	COG3335	DDE superfamily endonuclease
TthSNM11_13420	COG2897	thiosulfate sulfurtransferase activity
TthSNM11_13430	COG1760	l-serine dehydratase
TthSNM11_13440	COG2197	response regulator
TthSNM11_13450	COG0335	large ribosomal subunit rRNA binding
TthSNM11_13460	COG0336	Belongs to the RNA methyltransferase TrmD family
TthSNM11_13470	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
TthSNM11_13480	COG1837	Belongs to the UPF0109 family
TthSNM11_13490	COG0228	four-way junction DNA binding
TthSNM11_13520	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM11_13530	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM11_13530	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM11_13540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TthSNM11_13560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TthSNM11_13580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TthSNM11_13590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
TthSNM11_13600	COG1702	phosphate starvation-inducible protein PhoH
TthSNM11_13620	COG4864	UPF0365 protein
TthSNM11_13670	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
TthSNM11_13710	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM11_13710	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TthSNM11_13760	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
TthSNM11_13780	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
TthSNM11_13790	COG1397	ADP-ribosylglycohydrolase
TthSNM11_13800	COG2239	Acts as a magnesium transporter
TthSNM11_13810	COG2304	oxidoreductase activity
TthSNM11_13820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM11_13820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TthSNM11_13840	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM11_13840	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TthSNM11_13850	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TthSNM11_13860	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
TthSNM11_13870	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
TthSNM11_13880	COG0006	proline dipeptidase activity
TthSNM11_13900	COG0739	heme binding
TthSNM11_13920	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
TthSNM11_13930	COG0254	rRNA binding
TthSNM11_14190	COG4383	Mu-like prophage protein gp29
TthSNM11_14450	COG4397	Mu-like prophage major head subunit gpT
TthSNM11_14470	COG5005	Phage virion morphogenesis
TthSNM11_14530	COG2001	Belongs to the MraZ family
TthSNM11_14540	COG0275	rRNA processing
TthSNM11_14560	COG0768	penicillin binding
TthSNM11_14570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
TthSNM11_14590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM11_14600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
TthSNM11_14610	COG0772	Belongs to the SEDS family
TthSNM11_14620	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TthSNM11_14630	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
TthSNM11_14640	COG0812	UDP-N-acetylmuramate dehydrogenase activity
TthSNM11_14680	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
TthSNM11_14720	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
TthSNM11_14740	COG0159	tryptophan synthase activity
TthSNM11_14750	COG0133	tryptophan synthase activity
TthSNM11_14760	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
TthSNM11_14770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TthSNM11_14780	COG1744	ABC transporter substrate-binding protein PnrA-like
TthSNM11_14790	COG3845	ABC transporter
TthSNM11_14890	COG0438	transferase activity, transferring glycosyl groups
TthSNM11_14900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
TthSNM11_14920	COG0039	L-malate dehydrogenase activity
TthSNM11_14930	COG2819	hydrolase of the alpha beta superfamily
TthSNM11_14960	COG0247	lactate metabolic process
TthSNM11_14960	COG2181	nitrate reductase activity
TthSNM11_14980	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
TthSNM11_14990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
TthSNM11_15000	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TthSNM11_15020	COG0439	Biotin carboxylase
TthSNM11_15030	COG0511	ligase activity, forming carbon-carbon bonds
TthSNM11_15040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
TthSNM11_15080	COG0010	Belongs to the arginase family
TthSNM11_15110	COG1100	Small GTP-binding protein
TthSNM11_15130	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TthSNM11_15140	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TthSNM11_15160	COG2814	Major facilitator Superfamily
TthSNM11_15190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
TthSNM11_15200	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM11_15210	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
TthSNM11_15220	COG0589	response to stress
TthSNM11_15240	COG2239	Acts as a magnesium transporter
TthSNM11_15250	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
TthSNM11_15260	COG0745	RESPONSE REGULATOR receiver
TthSNM11_15270	COG5002	protein histidine kinase activity
TthSNM11_15280	COG1960	acyl-CoA dehydrogenase activity
TthSNM11_15290	COG2086	electron transfer activity
TthSNM11_15300	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TthSNM11_15320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM11_15330	COG1573	uracil-dna glycosylase
TthSNM11_15340	COG1796	DNA polymerase
TthSNM11_15340	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
TthSNM11_15370	COG2309	aminopeptidase activity
TthSNM11_15410	COG2873	o-acetylhomoserine
TthSNM11_15420	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM11_15440	COG1126	abc transporter atp-binding protein
TthSNM11_15460	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthSNM11_15470	COG3311	Transcriptional regulator
TthSNM11_15490	COG0134	indole-3-glycerol-phosphate synthase activity
TthSNM11_15500	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
TthSNM11_15520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
TthSNM11_15550	COG0765	amino acid transport
TthSNM11_15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TthSNM11_15590	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TthSNM11_15600	COG0569	domain protein
TthSNM11_15610	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM11_15620	COG1426	Protein conserved in bacteria
TthSNM11_15630	COG2313	pseudouridylate synthase activity
TthSNM11_15650	COG3001	Fructosamine kinase
TthSNM11_15660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM11_15680	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TthSNM11_15710	COG0012	GTP binding
TthSNM11_15720	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
TthSNM11_15740	COG0424	maF-like protein
TthSNM11_15770	COG0768	penicillin binding
TthSNM11_15780	COG0850	regulation of cytokinetic process
TthSNM11_15830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
TthSNM11_15840	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM11_15860	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
TthSNM11_15890	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
TthSNM11_15950	COG1131	(ABC) transporter
TthSNM11_15980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM11_16010	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
TthSNM11_16020	COG0440	acetolactate synthase activity
TthSNM11_16030	COG0028	Belongs to the TPP enzyme family
TthSNM11_16040	COG0492	ferredoxin-NADP+ reductase activity
TthSNM11_16060	COG4970	Tfp pilus assembly protein FimT
TthSNM11_16110	COG2165	general secretion pathway protein
TthSNM11_16180	COG0180	Tryptophanyl-tRNA synthetase
TthSNM11_16190	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM11_16200	COG0066	3-isopropylmalate dehydratase activity
TthSNM11_16210	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM11_16240	COG0300	oxidoreductase activity
TthSNM11_16250	COG0129	dihydroxy-acid dehydratase activity
TthSNM11_16270	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
TthSNM11_16280	COG1177	transmembrane transport
TthSNM11_16290	COG1176	ABC-type spermidine putrescine transport system, permease component I
TthSNM11_16300	COG3842	ATPase activity
TthSNM11_16310	COG0772	Belongs to the SEDS family
TthSNM11_16320	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
TthSNM11_16330	COG2894	cell division
TthSNM11_16340	COG1733	regulation of RNA biosynthetic process
TthSNM11_16360	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM11_16360	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TthSNM11_16380	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM11_16390	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM11_16400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM11_16420	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM11_16430	COG0653	protein targeting
TthSNM11_16440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
TthSNM11_16480	COG0393	Putative heavy-metal-binding
TthSNM11_16490	COG1205	dead DEAH box helicase
TthSNM11_16490	COG1111	helicase
TthSNM11_16520	COG0358	DNA primase activity
TthSNM11_16540	COG1250	3-hydroxyacyl-CoA dehydrogenase
TthSNM11_16550	COG0697	spore germination
TthSNM11_16560	COG0612	Peptidase, M16
TthSNM11_16570	COG0612	Peptidase, M16
TthSNM11_16580	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
TthSNM11_16610	COG1394	ATPase activity, coupled to movement of substances
TthSNM11_16620	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
TthSNM11_16630	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
TthSNM11_16640	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM11_16650	COG1527	subunit (C
TthSNM11_16660	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
TthSNM11_16680	COG1269	ATP hydrolysis coupled proton transport
TthSNM11_16730	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
TthSNM11_16750	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TthSNM11_16780	COG0419	ATPase involved in DNA repair
TthSNM11_16790	COG0420	3'-5' exonuclease activity
TthSNM11_16830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TthSNM11_16840	COG2884	Cell division ATP-binding protein ftsE
TthSNM11_16850	COG0793	Belongs to the peptidase S41A family
TthSNM11_16890	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM11_16890	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TthSNM11_16900	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
TthSNM11_16910	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TthSNM11_16930	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM11_16940	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM11_16950	COG1129	ABC transporter
TthSNM11_16960	COG0746	molybdenum cofactor guanylyltransferase activity
TthSNM11_16980	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM11_17020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
TthSNM11_17030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TthSNM11_17040	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
TthSNM11_17060	COG0517	IMP dehydrogenase activity
TthSNM11_17060	COG1994	Peptidase M50
TthSNM11_17070	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM11_17090	COG2358	TRAP transporter, solute receptor (TAXI family
TthSNM11_17120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TthSNM11_17130	COG0788	formyltetrahydrofolate deformylase activity
TthSNM11_17140	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
TthSNM11_17150	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
TthSNM11_17160	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
TthSNM11_17180	COG2010	Cytochrome c
TthSNM11_17200	COG0737	Belongs to the 5'-nucleotidase family
TthSNM11_17210	COG0174	glutamine synthetase
TthSNM11_17230	COG0559	Belongs to the binding-protein-dependent transport system permease family
TthSNM11_17270	COG0747	negative chemotaxis
TthSNM11_17280	COG0601	transmembrane transport
TthSNM11_17290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM11_17310	COG0285	dihydrofolate synthase activity
TthSNM11_17320	COG1132	(ABC) transporter
TthSNM11_17330	COG1132	(ABC) transporter
TthSNM11_17340	COG0372	Belongs to the citrate synthase family
TthSNM11_17350	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
TthSNM11_17360	COG1482	cell wall glycoprotein biosynthetic process
TthSNM11_17380	COG1515	deoxyribonuclease V activity
TthSNM11_17400	COG0776	regulation of translation
TthSNM11_17430	COG2197	response regulator
TthSNM11_17440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
TthSNM11_17450	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
TthSNM11_17460	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TthSNM11_17470	COG1324	tolerance protein
TthSNM11_17500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM11_17540	COG2205	protein histidine kinase activity
TthSNM11_17570	COG0247	lactate metabolic process
TthSNM11_17580	COG1139	Iron-sulfur cluster binding protein
TthSNM11_17590	COG1556	Lactate utilization protein
TthSNM11_17610	COG1752	Esterase of the alpha-beta hydrolase superfamily
TthSNM11_17620	COG2815	serine threonine protein kinase
TthSNM11_17620	COG0515	serine threonine protein kinase
TthSNM11_17640	COG0860	N-Acetylmuramoyl-L-alanine amidase
TthSNM11_17660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
TthSNM11_17750	COG0473	3-isopropylmalate dehydrogenase activity
TthSNM11_17800	COG1450	Type ii and iii secretion system protein
TthSNM11_17810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
TthSNM11_17820	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
TthSNM11_17830	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
TthSNM11_17840	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TthSNM11_17840	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
TthSNM11_17850	COG0736	holo-[acyl-carrier-protein] synthase activity
TthSNM11_17880	COG1160	GTP binding
TthSNM11_17890	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
TthSNM11_17900	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TthSNM11_17900	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TthSNM11_17910	COG0083	homoserine kinase activity
TthSNM11_17930	COG0268	Binds directly to 16S ribosomal RNA
TthSNM11_17950	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
TthSNM11_17960	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM11_17980	COG4235	cytochrome complex assembly
TthSNM11_17980	COG3088	subunit of a heme lyase
TthSNM11_17990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TthSNM11_18000	COG1138	Cytochrome C-type biogenesis protein
TthSNM11_18010	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
TthSNM11_18020	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM11_18030	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TthSNM11_18040	COG4133	protoheme IX ABC transporter activity
TthSNM11_18050	COG0785	Cytochrome C biogenesis protein
TthSNM11_18060	COG3258	Cytochrome c
TthSNM11_18080	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM11_18110	COG3258	Cytochrome c
TthSNM11_18120	COG2010	Cytochrome c
TthSNM11_18130	COG0737	Belongs to the 5'-nucleotidase family
TthSNM11_18140	COG2010	Cytochrome c
TthSNM11_18150	COG3258	Cytochrome c
TthSNM11_18190	COG2010	Cytochrome c
TthSNM11_18200	COG3842	ATPase activity
TthSNM11_18260	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM11_18270	COG3360	Dodecin
TthSNM11_18300	COG1024	Enoyl-CoA hydratase
TthSNM11_18310	COG0813	purine-nucleoside phosphorylase activity
TthSNM11_18320	COG1136	(ABC) transporter
TthSNM11_18330	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TthSNM11_18340	COG2045	Belongs to the ComB family
TthSNM11_18360	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
TthSNM11_18380	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
TthSNM11_18400	COG0107	imidazoleglycerol-phosphate synthase activity
TthSNM11_18410	COG0140	phosphoribosyl-ATP diphosphatase activity
TthSNM11_18410	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
TthSNM11_18420	COG1494	fructose-1,6-bisphosphatase
TthSNM11_18430	COG0686	Belongs to the AlaDH PNT family
TthSNM11_18440	COG0427	acetyl-CoA hydrolase
TthSNM11_18450	COG0084	hydrolase, TatD family'
TthSNM11_18460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
TthSNM11_18480	COG0017	Asparaginyl-tRNA synthetase
TthSNM11_18490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
TthSNM11_18520	COG2009	succinate dehydrogenase
TthSNM11_18530	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
TthSNM11_18590	COG0318	PFAM AMP-dependent synthetase and ligase
TthSNM11_18600	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
TthSNM11_18610	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
TthSNM11_18620	COG0504	CTP synthase activity
TthSNM11_18640	COG0067	glutamate synthase
TthSNM11_18640	COG0069	glutamate synthase activity
TthSNM11_18640	COG0070	glutamate synthase
TthSNM11_18660	COG0840	transmembrane signaling receptor activity
TthSNM11_18670	COG0305	Participates in initiation and elongation during chromosome replication
TthSNM11_18690	COG0475	glutathione-regulated potassium exporter activity
TthSNM11_18700	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
TthSNM11_18700	COG0617	tRNA 3'-terminal CCA addition
TthSNM11_18700	COG0517	IMP dehydrogenase activity
TthSNM11_18730	COG0475	glutathione-regulated potassium exporter activity
TthSNM11_18740	COG0490	domain, Protein
TthSNM11_18780	COG3118	belongs to the thioredoxin family
TthSNM11_18840	COG0542	response to heat
TthSNM11_18850	COG0789	Transcriptional regulator
TthSNM11_18860	COG0484	heat shock protein binding
TthSNM11_18870	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
TthSNM11_18880	COG0443	Heat shock 70 kDa protein
TthSNM11_18890	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TthSNM11_18900	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TthSNM11_18910	COG0616	signal peptide processing
TthSNM11_18940	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
TthSNM11_18950	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
TthSNM11_18960	COG0714	Associated with various cellular activities
TthSNM11_18970	COG0574	Belongs to the PEP-utilizing enzyme family
TthSNM11_18970	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TthSNM11_18980	COG1272	protein, Hemolysin III
TthSNM11_19000	COG5002	protein histidine kinase activity
TthSNM11_19000	COG3850	Histidine kinase
TthSNM11_19020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
TthSNM11_19050	COG1011	Hydrolase
TthSNM11_19100	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TthSNM11_19130	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
TthSNM11_19150	COG0047	phosphoribosylformylglycinamidine synthase activity
TthSNM11_19170	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TthSNM11_19180	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TthSNM11_19190	COG0116	Belongs to the methyltransferase superfamily
TthSNM11_19220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
TthSNM11_19230	COG0497	DNA recombination
TthSNM11_19250	COG0604	alcohol dehydrogenase
TthSNM11_19290	COG0585	pseudouridine synthase activity
TthSNM11_19320	COG0557	exoribonuclease II activity
TthSNM11_19330	COG0538	isocitrate dehydrogenase activity
TthSNM11_19340	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
TthSNM11_19370	COG4974	Belongs to the 'phage' integrase family
TthSNM11_19400	COG0590	tRNA wobble adenosine to inosine editing
TthSNM11_19400	COG0037	tRNA processing
TthSNM11_19440	COG2050	protein possibly involved in aromatic compounds catabolism
TthSNM11_19460	COG0322	excinuclease ABC activity
TthSNM11_19470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM11_19480	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TthSNM11_19490	COG1854	S-ribosylhomocysteine lyase activity
TthSNM11_19500	COG0519	Catalyzes the synthesis of GMP from XMP
TthSNM11_19500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
TthSNM11_19520	COG4274	PFAM GYD family protein
TthSNM11_19540	COG0328	RNA-DNA hybrid ribonuclease activity
TthSNM11_19550	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TthSNM11_19560	COG2095	MarC family integral membrane protein
TthSNM11_19570	COG1438	arginine binding
TthSNM11_19580	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
TthSNM11_19590	COG1758	RNA polymerase activity
TthSNM11_19600	COG0194	GDP metabolic process
TthSNM11_19620	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthSNM11_19630	COG2385	sporulation resulting in formation of a cellular spore
TthSNM11_19640	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
TthSNM11_19660	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
TthSNM11_19730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM11_19740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TthSNM11_19750	COG1012	belongs to the aldehyde dehydrogenase family
TthSNM11_19760	COG0506	proline dehydrogenase activity
TthSNM11_19800	COG0156	8-amino-7-oxononanoate synthase activity
TthSNM11_19810	COG0732	type I restriction modification DNA specificity domain
TthSNM11_19810	COG0827	DNA restriction-modification system
TthSNM11_19840	COG0187	DNA topoisomerase II activity
TthSNM11_19850	COG1181	Belongs to the D-alanine--D-alanine ligase family
TthSNM11_19860	COG0193	aminoacyl-tRNA hydrolase activity
TthSNM11_19870	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
TthSNM11_19900	COG0515	serine threonine protein kinase
TthSNM11_19900	COG2815	serine threonine protein kinase
TthSNM11_19910	COG0631	protein serine/threonine phosphatase activity
TthSNM11_19940	COG0113	porphobilinogen synthase activity
TthSNM11_19950	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
TthSNM11_19960	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
TthSNM11_20010	COG0823	Involved in the tonB-independent uptake of proteins
TthSNM11_20010	COG1506	peptidase
TthSNM11_20010	COG4946	Tricorn protease homolog
TthSNM11_20020	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
TthSNM11_20030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
TthSNM11_20070	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
TthSNM11_20080	COG1011	Hydrolase
TthSNM11_20130	COG0537	adenosine 5'-monophosphoramidase activity
TthSNM11_20140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TthSNM11_20180	COG0220	tRNA (guanine-N7-)-methyltransferase activity
TthSNM11_20190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
TthSNM11_20200	COG0071	Belongs to the small heat shock protein (HSP20) family
TthSNM11_20210	COG2897	thiosulfate sulfurtransferase activity
TthSNM11_20220	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TthSNM11_20240	COG1764	response to oxidative stress
TthSNM11_20270	COG1840	ABC-type Fe3 transport system, periplasmic component
TthSNM11_20290	COG3842	ATPase activity
TthSNM11_20300	COG0101	tRNA pseudouridine synthase activity
TthSNM11_20310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TthSNM11_20320	COG0601	transmembrane transport
TthSNM11_20350	COG0006	proline dipeptidase activity
TthSNM11_20360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
TthSNM11_20390	COG1166	arginine decarboxylase activity
TthSNM11_20400	COG3706	GGDEF domain
TthSNM11_20410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TthSNM11_20420	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
TthSNM11_20430	COG1611	Belongs to the LOG family
TthSNM11_20440	COG1193	negative regulation of DNA recombination
TthSNM11_20460	COG0366	Alpha amylase catalytic
TthSNM11_20500	COG0366	Alpha amylase catalytic
TthSNM11_20570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TthSNM11_20580	COG0142	geranyltranstransferase activity
TthSNM11_20600	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
TthSNM11_20660	COG0203	ribosomal protein L17
TthSNM11_20670	COG0202	RNA polymerase activity
TthSNM11_20680	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
TthSNM11_20690	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
TthSNM11_20700	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
TthSNM11_20710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
TthSNM11_20730	COG0563	adenylate kinase activity
TthSNM11_20740	COG0201	protein transport
TthSNM11_20790	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
TthSNM11_20800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
TthSNM11_20810	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
TthSNM11_20860	COG0255	Belongs to the universal ribosomal protein uL29 family
TthSNM11_20870	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
TthSNM11_20880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
TthSNM11_20900	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TthSNM11_20910	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
TthSNM11_20920	COG0089	rRNA binding
TthSNM11_20930	COG0088	Forms part of the polypeptide exit tunnel
TthSNM11_20950	COG0051	transcription antitermination factor activity, RNA binding
TthSNM11_20960	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
TthSNM11_20980	COG0049	tRNA binding
TthSNM11_21010	COG0442	prolyl-tRNA aminoacylation
TthSNM11_21030	COG1115	amino acid carrier protein
TthSNM11_21070	COG1489	DNA binding
TthSNM11_21100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
TthSNM11_21140	COG0432	Pfam Uncharacterised protein family UPF0047
TthSNM11_21150	COG3253	May function as heme-dependent peroxidase
TthSNM11_21160	COG0668	transmembrane transport
TthSNM11_21180	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
TthSNM11_21190	COG2217	Heavy metal translocating P-type atpase
TthSNM11_21230	COG0745	RESPONSE REGULATOR receiver
TthSNM11_21240	COG2205	protein histidine kinase activity
TthSNM11_21290	COG2226	methyltransferase
TthSNM11_21350	COG2132	Multicopper oxidase
TthSNM11_21370	COG2217	Heavy metal translocating P-type atpase
TthSNM11_21380	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TthSNM11_21390	COG0822	iron-sulfur transferase activity
TthSNM11_21430	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
TthSNM11_21450	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
TthSNM11_21460	COG0284	orotidine-5'-phosphate decarboxylase activity
TthSNM11_21480	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
TthSNM11_21500	COG0416	fatty acid biosynthetic process
TthSNM11_21510	COG3118	belongs to the thioredoxin family
TthSNM11_21520	COG1185	polyribonucleotide nucleotidyltransferase activity
TthSNM11_21530	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TthSNM11_21550	COG0438	transferase activity, transferring glycosyl groups
TthSNM11_21590	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TthSNM11_21620	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TthSNM11_21630	COG3706	GGDEF domain
TthSNM11_21690	COG0437	4 iron, 4 sulfur cluster binding
TthSNM11_21720	COG0825	malonyl-CoA metabolic process
TthSNM11_21730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
TthSNM11_21820	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
TthSNM11_21870	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
TthSNM11_21880	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
TthSNM11_21890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
TthSNM11_21900	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TthSNM11_21990	COG0315	cyclic pyranopterin monophosphate synthase activity
TthSNM11_22010	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
TthSNM11_22040	COG1694	Mazg nucleotide pyrophosphohydrolase
TthSNM11_22050	COG1803	Methylglyoxal synthase
TthSNM11_22070	COG0301	tRNA thio-modification
TthSNM11_22080	COG0154	amidase activity
TthSNM11_22090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
TthSNM11_22140	COG2154	pterin-4-alpha-carbinolamine dehydratase
TthSNM11_22150	COG1607	acyl-coa hydrolase
TthSNM11_22170	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
TthSNM11_22180	COG4149	molybdate abc transporter
TthSNM11_22190	COG1840	ABC-type Fe3 transport system, periplasmic component
TthSNM11_22220	COG0235	Class ii aldolase
TthSNM11_22230	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
TthSNM11_22240	COG0085	RNA polymerase activity
TthSNM11_22260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
TthSNM11_22270	COG1077	Cell shape determining protein MreB Mrl
TthSNM11_22280	COG1418	mRNA catabolic process
TthSNM11_22280	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
TthSNM11_22290	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
TthSNM11_22300	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TthSNM11_22310	COG1058	Belongs to the CinA family
TthSNM11_22310	COG1546	Belongs to the CinA family
TthSNM11_22320	COG0354	folic acid binding
TthSNM11_22350	COG4948	Mandelate Racemase Muconate Lactonizing
TthSNM11_22380	COG1175	transmembrane transport
TthSNM11_22400	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
TthSNM11_22420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TthSNM11_22440	COG1136	(ABC) transporter
TthSNM11_22440	COG0577	efflux transmembrane transporter activity
TthSNM11_22450	COG4181	ATPase activity
TthSNM11_22460	COG0446	pyridine nucleotide-disulphide oxidoreductase
TthSNM11_22490	COG0396	ATPase activity
TthSNM11_22500	COG0719	Fe-S assembly protein
TthSNM11_22510	COG0719	Fe-S assembly protein
TthSNM11_22520	COG2146	nitrite reductase [NAD(P)H] activity
TthSNM11_22540	COG0512	Glutamine amidotransferase of anthranilate synthase
TthSNM11_22550	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TthSNM11_22610	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TthSNM11_22620	COG2226	methyltransferase
TthSNM11_22630	COG4603	Belongs to the binding-protein-dependent transport system permease family
TthSNM11_22640	COG1079	Belongs to the binding-protein-dependent transport system permease family
TthSNM11_22670	COG1774	PSP1 C-terminal conserved region
TthSNM11_22680	COG0470	DNA polymerase III
TthSNM11_22720	COG0497	DNA recombination
TthSNM11_22750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
TthSNM11_22780	COG0302	gtp cyclohydrolase
TthSNM11_22830	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TthSNM11_22850	COG0395	ABC-type sugar transport system, permease component
TthSNM11_22860	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TthSNM11_22870	COG1131	(ABC) transporter
TthSNM11_22910	COG0556	nucleotide-excision repair
TthSNM11_22920	COG0497	DNA recombination
TthSNM11_22930	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
TthSNM11_22940	COG0445	tRNA wobble uridine modification
TthSNM11_22990	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
TthSNM11_22990	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
TthSNM11_23000	COG1543	Belongs to the glycosyl hydrolase 57 family
TthSNM11_23010	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM11_23020	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
TthSNM11_23030	COG0189	ligase activity
TthSNM11_23060	COG0066	3-isopropylmalate dehydratase activity
TthSNM11_23070	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
TthSNM11_23100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TthSNM11_23110	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
TthSNM11_23120	COG1960	acyl-CoA dehydrogenase activity
TthSNM11_23130	COG0163	prenyltransferase activity
TthSNM11_23190	COG4555	ABC transporter
TthSNM11_23210	COG2096	Adenosyltransferase
TthSNM11_23240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
TthSNM11_23250	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
TthSNM11_23280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TthSNM11_23290	COG0723	plastoquinol--plastocyanin reductase activity
TthSNM11_23340	COG1653	transport
TthSNM11_23350	COG0820	rRNA (adenine-C2-)-methyltransferase activity
TthSNM11_23360	COG1960	acyl-CoA dehydrogenase activity
TthSNM11_23380	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
TthSNM11_23480	COG3956	TIGRFAM MazG family protein
TthSNM11_23490	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
TthSNM11_23500	COG0693	protein deglycase activity
TthSNM11_23510	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
TthSNM11_23530	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TthSNM11_23540	COG1937	Protein conserved in bacteria
TthSNM11_23560	COG0674	pyruvate-flavodoxin oxidoreductase activity
TthSNM11_23560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
TthSNM11_23570	COG1013	pyruvate-flavodoxin oxidoreductase activity
TthSNM11_23620	COG0205	6-phosphofructokinase activity
TthSNM11_23630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TthSNM11_23650	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TthSNM11_23680	COG2333	competence protein COMEC
TthSNM11_23680	COG0658	competence protein
TthSNM11_23690	COG1475	DNA binding
TthSNM11_23700	COG1192	Involved in chromosome partitioning
TthSNM11_23710	COG0357	Ribosomal RNA small subunit methyltransferase G
TthSNM11_23720	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TthSNM11_23730	COG1653	transport
TthSNM11_23750	COG0395	ABC-type sugar transport system, permease component
TthSNM11_23760	COG1692	metallophosphoesterase
TthSNM11_23790	COG3454	Phosphonate metabolism
TthSNM11_23800	COG4778	phosphonate C-P lyase system protein PhnL
TthSNM11_23810	COG4107	phosphonate C-P lyase system protein PhnK
TthSNM11_23820	COG3627	carbon phosphorus lyase activity
TthSNM11_23860	COG3639	organic phosphonate transmembrane transporter activity
TthSNM11_23880	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
TthSNM11_24050	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
TthSNM11_24060	COG1475	DNA binding
TthSNM11_24070	COG1192	Involved in chromosome partitioning
TthSNM11_24250	COG2385	sporulation resulting in formation of a cellular spore
TthSNM11_24260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TthSNM11_24270	COG3335	DDE superfamily endonuclease
TthSNM11_24480	COG2002	toxin-antitoxin pair type II binding
TthSNM11_24520	COG3335	DDE superfamily endonuclease
TthSNM11_24600	COG0803	Belongs to the bacterial solute-binding protein 9 family
TthSNM11_24650	COG0523	cobalamin synthesis protein
TthSNM11_24660	COG0521	Mo-molybdopterin cofactor biosynthetic process
TthSNM11_24720	COG0395	ABC-type sugar transport system, permease component
TthSNM11_24770	COG3335	DDE superfamily endonuclease
TthSNM11_24830	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TthSNM11_24840	COG1175	transmembrane transport
TthSNM11_24870	COG4143	(ABC) transporter
TthSNM11_25090	COG4974	Belongs to the 'phage' integrase family
TthSNM11_t00360	COG0544	peptidyl-prolyl cis-trans isomerase activity